CN115300487A - Uterus warming patch and manufacturing process thereof - Google Patents
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- CN115300487A CN115300487A CN202211084273.XA CN202211084273A CN115300487A CN 115300487 A CN115300487 A CN 115300487A CN 202211084273 A CN202211084273 A CN 202211084273A CN 115300487 A CN115300487 A CN 115300487A
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Abstract
The application provides a uterus warming patch and a manufacturing process thereof, and relates to the technical field of medicines. A uterus warming patch comprising: angelica, ligusticum wallichii, red paeony root, cattail pollen, trogopterus dung, corydalis tuber, myrrh, cinnamon, dried ginger, fennel, folium artemisiae argyi, szechwan chinaberry fruit, safflower, eucommia bark and liquorice. The uterus warming patch has the effects of activating blood circulation, removing blood stasis, warming channels and relieving pain, and is mainly used for treating abdominal pain caused by cold coagulation and blood stasis in lower abdomen, and the abdominal pain is reduced when the abdominal pain is warm; the menstrual blood has lumps, and the pain is relieved under the lumps; the lower abdomen is cold, warm and warm; scanty menstruation and dark color; dysmenorrhea, infertility, etc. caused by congealing cold and blood stasis. According to the preparation process, the raw materials are crushed into the nano powder to prepare the patch, so that the bioavailability of the effective ingredients of the medicine in the patch is high, the percutaneous absorption of the medicine is facilitated, the patch takes effect more quickly, the medicine effect is better, and the treatment effect is effectively ensured.
Description
Technical Field
The application relates to the technical field of medicines, in particular to a uterus warming patch and a manufacturing process thereof.
Background
Dysmenorrhea is one of the most common gynecological diseases of women. Modern medicine believes that dysmenorrhea occurs in association with vegetative nerve functional disturbance and prostaglandin release. The traditional Chinese medicine considers that the disease location of dysmenorrhea is in uterus and Chong and ren meridians, and the main pathogenesis is 'obstruction leading to pain' or 'failing to nourish leading to pain'. Clinically, abdominal pain during menstruation is mostly due to cold syndrome and blood stasis, and this disease is treated by warming meridians to dispel cold, activating blood circulation, removing blood stasis and alleviating pain. Modern pharmacological studies prove that the lower abdomen stasis removing soup can obviously relieve the uterine swelling of a rat caused by a plastic tube, and has a relatively obvious inhibiting effect on subcutaneous granuloma of the rat caused by a cotton ball, which indicates that the soup has an anti-inflammatory effect. In clinical application, aiming at different symptoms of dysmenorrheal, the medicines are increased and decreased according to symptoms, are flexibly tailored, and are combined to play the effects of warming channels and expelling cold, activating blood and dissolving stasis, and promoting qi circulation and relieving pain, so that cold people can be warmed, stasis people can be dissolved, the pathogeny is removed, channels and collaterals and qi and blood are smooth, thoroughfare and conception vessels and uterus blood are harmonized, and the circulation is not painful, and the symptoms are not repeated periodically along with menstruation.
At present, the lower abdomen stasis removing decoction evolves except traditional Chinese medicine decoction, granules, pills, capsules and plaster preparations are available on the market. The decoction can be added or subtracted according to symptoms, can fully exert the comprehensive curative effect and characteristics of various components of the prescription medicine, has quick effect, but needs to be prepared and taken at the same time, is easy to mildew after long-term storage, has poor taste, is complicated to decoct and is inconvenient to carry. The granule maintains the traditional decoction basis, overcomes the difficulty in decocting the traditional Chinese medicines, is more convenient to carry, store and take compared with a liquid preparation, but has the advantages of high price, easy deliquescence, poor mixing performance during the dissolution, easy layering, frequent taking and poor taste. The pill has the advantages of slow dissolution and drug release, prolonged drug effect, reduced toxicity and irritation, reduced adverse reaction, portability, inconvenient administration, easy dissolution and slow disintegration due to improper production and operation, poor taste, and difficulty in swallowing. The capsule can cover up the special smell of the medicine and improve the stability of the medicine, has relatively low price, quick response and portability, but has the phenomena of difficult swallowing and more times of taking.
Disclosure of Invention
The application aims to provide a uterus warming patch which has the effects of activating blood circulation, removing blood stasis, warming meridians and relieving pain, is mainly used for treating abdominal pain caused by cold coagulation and blood stasis in lower abdomen, and is reduced when the temperature is increased; menstrual blood clots and pain is relieved under the clots; the lower abdomen is cold, warm and warm; scanty menstruation and dark color; dysmenorrhea, infertility, etc. caused by congealing cold and blood stasis.
Another objective of the present application is to provide a process for preparing a uterus warming patch, wherein the patch is prepared by pulverizing the raw materials into nanopowder, so that the bioavailability of the active ingredients in the patch is high, the transdermal absorption of the drug is facilitated, the patch has faster onset of action and better drug effect, and the treatment effect is effectively ensured.
The technical problem to be solved by the application is achieved by adopting the following technical scheme.
The application provides a uterus warming patch, which comprises the following raw materials in parts by weight: 6-15 parts of angelica sinensis, 6-15 parts of ligusticum wallichii, 3-10 parts of radix paeoniae rubra, 5-15 parts of pollen typhae, 5-10 parts of trogopterus dung, 5-20 parts of rhizoma corydalis, 6-10 parts of myrrh, 3-9 parts of cinnamon, 3-9 parts of rhizoma zingiberis, 5-15 parts of fennel, 5-20 parts of folium artemisiae argyi, 5-10 parts of szechwan chinaberry fruit, 3-10 parts of safflower, 5-15 parts of eucommia ulmoides and 3-9 parts of liquorice.
The application provides a manufacturing process of a uterus warming patch, which comprises the following steps:
crushing the raw materials by adopting an ultra-micro nano powder to obtain nano powder; heating Vaseline to liquid, mixing Vaseline liquid and nanometer powder, cooling to obtain ointment, adding the ointment into the non-woven fabric blank patch, covering the non-woven fabric blank patch with paper, and refrigerating for storage.
The embodiment of the application has at least the following beneficial effects:
in the application, the uterus warming patch has the curative effects of activating blood circulation, removing blood stasis, warming meridians and relieving pain, and the medicine is absorbed into viscera and meridians through local transdermal absorption of skin, so that the decomposition of liver and gastrointestinal tract is avoided, and the utilization rate of the medicine is fully improved. In the prescription, angelica, rhizoma ligustici wallichii, cattail pollen and trogopterus dung are used as monarch drugs, and the effects of activating blood circulation, removing stasis and relieving pain are achieved; cinnamon, dried ginger, fennel and folium artemisiae argyi are used as ministerial drugs, the effects of warming uterus and relieving pain are achieved, and safflower is used as the ministerial drug, and the effects of promoting blood circulation and removing blood stasis of the monarch drug can be enhanced; corydalis tuber and szechwan chinaberry fruit are adjuvant drugs, promote qi circulation to relieve pain, and strengthen the analgesic property of monarch drugs and ministerial drugs; myrrh is an adjuvant drug, and has the effects of promoting blood circulation to arrest pain and strengthening the pain; the red paeony root is an adjuvant drug and can promote blood circulation to remove blood stasis and prevent the drugs from being over-warm; eucommia bark is used as an adjuvant drug, so that the kidney is nourished and the waist is strengthened to relieve pain, and the warm tonifying property is strengthened; licorice root, radix Glycyrrhizae is used as a guiding drug to coordinate the effects of the other drugs in the recipe, and it can strengthen the tonifying effect when processed with honey. The prescription has proper compatibility, accurate dosage and obvious clinical curative effect, and is prepared into a paste acupoint plaster for treating some chronic and refractory diseases, and is particularly suitable for female patients with frequent dysmenorrhea. In addition, the acupoint application therapy has a long development history, wide application range, definite clinical curative effect, safety, reliability, stable medicine property, no special smell, convenient storage and low carrying cost.
In the application, the raw materials are crushed into nano powder to prepare the patch which has good absorption performance and high bioavailability, can be used for treating or assisting in treating chronic and easily-recurrent dysmenorrhea for a long time, makes up the defects of bitter taste, high price, difficult decoction and the like of traditional Chinese medicine decoction, gives full play to the advantages of the traditional Chinese medicine acupoint patch, can fully utilize the medicine, gives full play to the medicine effect to the greatest extent and ensures the treatment effectiveness. The solid lipid nanoparticles can form a film on the surface of skin because a high-concentration surfactant is not used in the preparation process, promote the absorption of the medicament through the hydration of epidermis after partial sealing, and increase the contact time and the area of the medicament and the horny layer, thereby being beneficial to the percutaneous absorption of the medicament.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions of the embodiments of the present application will be clearly and completely described below. The examples, in which specific conditions are not specified, were carried out according to conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.
It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. The present application will be described in detail below with reference to specific examples.
The lower abdomen is marked by congealing cold and blood stasis in the lower abdomen. The lower energizer includes the liver and kidney, and the lower abdomen is afflicted with the miscellaneous diseases such as the lower abdomen mass pain or the irregular menstruation due to the dysfunction of the liver and kidney and other organs, congealing cold, qi stagnation, obstructed discharge and blood stasis discomfort. The therapeutic principle is mainly to activate blood and resolve stasis, regulate qi and alleviate pain, tonify and nourish kidney, and the prescription is as follows.
The uterus warming patch comprises the following raw materials in parts by weight: 6-15 parts of angelica sinensis, 6-15 parts of ligusticum wallichii, 3-10 parts of red paeony root, 5-15 parts of pollen typhae, 5-10 parts of trogopterus dung, 5-20 parts of rhizoma corydalis, 6-10 parts of myrrh, 3-9 parts of cinnamon, 3-9 parts of dried ginger, 5-15 parts of fennel, 5-20 parts of folium artemisiae argyi, 5-10 parts of szechwan chinaberry fruit, 3-10 parts of safflower, 5-15 parts of eucommia ulmoides and 3-9 parts of liquorice.
Dang Gui enters liver, heart and spleen meridians. Nourish blood, enrich blood, activate blood to regulate menstruation. It is usually combined with Bai Shao, shu Di Huang, chuan Xiong, xiang Fu, bai Shao and Huang Qi. The angelica has the obvious function of inhibiting platelet aggregation, and can reduce blood viscosity, reduce plasma fibrinogen, prolong prothrombin time and shorten erythrocyte and platelet electrophoresis time. When ferulic acid in the angelica can inhibit the action of TXA2 synthetase, and can also prevent arachidonic acid on a membrane from dissociating from phospholipid by inhibiting phospholipase A2, thereby blocking PG generation such as TAX2 and the like; can raise the cAMP level of blood platelet and inhibit the activity of phosphodiesterase, so as to play a role in inhibiting blood platelet aggregation.
Rhizoma Ligustici Chuanxiong, entering liver, gallbladder and pericardium channels, has effects of promoting blood circulation and activating qi-flowing, dispelling pathogenic wind and relieving pain, and can be used for treating menoxenia, dysmenorrhea, amenorrhea, puerperal abdominal pain and retained afterbirth caused by blood stasis and qi stagnation. It is the essential herb for regulating menstruation in gynecology, and often combined with Dang Gui, bai Shao and Xiang Fu. For distending pain in chest and hypochondrium due to liver qi stagnation, it is often combined with chai Hu and Yan Hu Suo. For coronary heart disease and angina pectoris, it is often combined with Dan Shen and Chi Shao. The ligusticum wallichii is the first medicament for removing blood stasis and melting thrombus, which is specially used for treating thrombus caused by blockage of heart blood stasis in all blood circulation promotion and blood stasis removal. The effective components of rhizoma Ligustici Chuanxiong mainly comprise phthalides (ligustilide, butylphthalide, senkyunolide A, I, J), phenolic acids (ferulic acid, coniferyl ferulate), alkaloids (ligustrazine), and polysaccharide. Wherein ligustilide has functions of prolonging prothrombin time, resisting platelet aggregation, and relaxing uterus and trachea smooth muscle; ferulic acid has effects of prolonging prothrombin time and replenishing blood; ligustrazine has effects of promoting blood circulation and removing blood stasis.
Red peony root, which is slightly cold in nature and bitter in taste, enters liver and spleen channels, has the functions of clearing heat, cooling blood, removing stasis and relieving pain, belongs to heat-clearing and blood-cooling medicines classified under heat-clearing medicines, and contains paeoniflorin, neopaeoniflorin, red paeoniflorin, red paeony element B, palmitic acid, dihydroapigenin, paeoniflorin, beta-sitosterol, camphorhydrocarbon, vanillic acid and the like.
Cattail pollen is neutral in nature and sweet in taste, enters liver channel and heart channel, stops bleeding, removes blood stasis and treats stranguria, belongs to the blood stasis removing and bleeding stopping medicine under the category of bleeding stopping medicines, and mainly contains flavone and steroid components. The product has effects in improving myocardial microcirculation, reducing blood lipid, resisting atherosclerosis, promoting blood coagulation, exciting uterus smooth muscle, relieving spasm of intestinal smooth muscle, inhibiting cellular immunity and humoral immunity, and relieving inflammation, bacteria, allergy and hemolysis. It can stop bleeding and resolve stasis, and is indicated for bleeding due to internal stagnation of blood stasis and blood failing to circulate through channels. In addition, it is light in body weight and can promote blood circulation, remove blood stasis and alleviate pain.
Trogopterus dung is warm in nature, salty and sweet in taste, enters liver channels, activates blood circulation to relieve pain, removes blood stasis to stop bleeding, removes stagnation, detoxifies and activates qi, belongs to the category of blood circulation-activating and blood stasis-removing medicaments, contains a large amount of resin, urea, uric acid and vitamin A substances, and is mainly used for treating pain caused by blood stasis in heart and abdomen, dysmenorrhea, blood stasis amenorrhea and postpartum abdominal stasis and pain. The product has antibacterial and antiinflammatory effects, and has effects in inhibiting platelet aggregation and resisting thrombi, improving cardiovascular system and microcirculation disturbance, and improving stress injury resistance and superoxide dismutase activity.
Corydalis tuber, belonging to liver, spleen and heart channel, promotes blood circulation to dissipate blood stasis, and promotes qi circulation to relieve pain. It is pungent, dispersing and warm in property, and has good actions of activating qi stagnation in blood and qi stagnation in middle and middle, so it is specially indicated for all kinds of pain in upper and lower parts of the body, and has good pain-relieving effect. For chest stuffiness and pain, it is combined with Dan Shen and Gua Lou. For stomachache, it is combined with Bai Shao and Zhi Shi, etc. For hypochondriac pain, it is combined with chai Hu. For dysmenorrhea, postpartum abdominal stagnant pain, it is combined with cyperus rotundus, angelica sinensis, safflower etc. Rhizoma corydalis can dilate coronary artery, increase coronary blood flow, inhibit platelet aggregation, and resist thrombosis.
Myrrh, mild in nature, pungent and bitter in flavor, entering heart channel, liver channel and spleen channel, dissipating blood stasis and relieving pain, eliminating swelling and promoting granulation, and removing stagnation, belongs to the blood circulation-promoting and pain-relieving herbs classified under the blood circulation-promoting and blood stasis-removing herbs, and mainly comprises alpha-hamaridiolic acid, beta-hamaridiolic acid, bisabolol, myrrh terpinol, eugenol, limonene, bisabolene and other components. Myrrh has the effect of promoting blood circulation and relieving pain, and is used together with herbs that promote qi and blood circulation, such as Chuan Xiong, which favors qi and blood, and brings out the best in each other when combined.
Cinnamon, pungent and sweet, high heat, entering kidney, spleen, heart and liver channels, tonifying fire and supporting yang, guiding fire to source, dispelling cold and relieving pain, activating blood and stimulating the menstrual flow, and warming and dredging channels and collaterals, and the main component is 75-90% of cinnamaldehyde. Cinnamon is warm food, can lead fire downwards, does not cause deficiency fire, is suitable for symptoms of upper heat and lower cold, has certain benefits for conditioning uterus cold for women, has the effects of warming stomach and uterus, and can effectively relieve the uterus cold for women.
Gan Jiang enters lung, spleen and stomach meridians, warms middle energizer to dispel cold, returns yang to activate collaterals, eliminates dampness and phlegm, and excels in warming middle energizer to return yang, so it is combined with various herbs for dissipating blood stasis in warm blood.
The fennel has warm nature and pungent taste, belongs to interior-warming medicines, and comprises various compounds such as volatile oil, sterol, triterpene, coumarin, amino acid and the like, and enters liver channel, spleen channel, stomach channel and kidney channel to dispel cold and relieve pain and regulate qi and stomach. Has the effects of warming channels, dispelling cold, promoting qi circulation and relieving pain for cold in uterus, and can be used for treating abdominal psychroalgia caused by cold in uterus, and relieving pain by soothing liver, regulating qi, warming kidney and dispelling cold.
Folium artemisiae argyi is pungent, bitter, warm and slightly toxic, enters liver, spleen and kidney channels, dispels cold, relieves pain, warms channels and stops bleeding.
Toosendan fruit, bitter in taste and cold in nature, enters liver, stomach, small intestine and bladder channels, soothes liver and regulates qi, kills parasites and treats tinea, promotes qi circulation and relieves pain, and can be used for treating lower abdominal distension and pain, hernia and abdominal pain and the like caused by qi stagnation and dampness stagnation.
Safflower, flos Carthami, which enters heart and liver meridians, promotes blood circulation to regulate menstruation, removes blood stasis to relieve pain, is often combined with Dang Gui, chuan Xiong, tao ren, etc. for abdominal pain due to stasis. For blood stasis and chest stuffiness and pain, pain due to blood vessel occlusion and pain due to blood stasis and traumatic injury, it is often combined with hong Hua and Dang Gui, etc. For stasis and chest stuffiness and pain, it is combined with Gua Lou Ling, dan Shen and Gui Zhi, etc. For pain and swelling due to blood vessel occlusion, it is combined with Chi Shao and Dang Gui, etc. The carthamin yellow has very obvious inhibition effect on platelet aggregation induced by adenosine diphosphate.
Eucommia bark, cortex Eucommiae, warm in nature and sweet in taste, enters liver and kidney meridians, tonifies liver and kidney, strengthens tendons and bones, prevents abortion, and belongs to yang tonics classified under deficiency tonics. The Eucommiae cortex contains Eucommiae cortex gelatin, glucoside, alkaloid, organic acid, pectin, vitamin C and various amino acids, and has effects of tranquilizing, relieving pain, promoting urination, delaying aging, enhancing physical strength, relieving fatigue, and enhancing nonspecific immunity.
The liquorice has mild nature and sweet taste, enters heart channel, stomach channel, spleen channel and lung channel, tonifies spleen and qi, relieves cough and eliminates phlegm, relieves spasm and pain, harmonizes drug properties, belongs to qi tonics classified under deficiency tonics, and can enable the tonifying effect to be mild and lasting without sudden.
In detail, the uterus warming plaster comprises, by weight, 8-12 parts of angelica sinensis, 8-12 parts of ligusticum wallichii, 3-8 parts of radix paeoniae rubra, 8-12 parts of pollen typhae, 5-8 parts of trogopterus dung, 10-15 parts of rhizoma corydalis, 6-8 parts of myrrh, 3-7 parts of cinnamon, 3-7 parts of rhizoma zingiberis, 7-11 parts of fennel, 10-15 parts of folium artemisiae argyi, 5-8 parts of szechwan chinaberry fruit, 3-8 parts of safflower, 10-15 parts of eucommia ulmoides and 5-9 parts of liquorice.
In detail, the uterus warming patch comprises, by weight, 10 parts of Chinese angelica, 10 parts of ligusticum wallichii, 5 parts of red peony root, 10 parts of pollen typhae, 7 parts of trogopterus dung, 12 parts of corydalis tuber, 7 parts of myrrh, 5 parts of cinnamon, 5 parts of dried ginger, 8 parts of common fennel fruit, 12 parts of folium artemisiae argyi, 7 parts of szechwan chinaberry fruit, 5 parts of safflower, 12 parts of eucommia bark and 7 parts of liquorice.
Transdermal administration of Chinese herbs is a common administration way, which allows the effective ingredients of Chinese herbs to enter the systemic circulation through skin absorption, resulting in systemic or local therapeutic effects. The transdermal drug delivery preparation can avoid the first pass effect of the liver and the damage of the gastrointestinal tract, reduce the drug delivery times, prolong the drug delivery time, maintain constant effective blood concentration, reduce the toxic and side effects of the drug and improve the curative effect. However, because the transdermal administration permeation rate of traditional Chinese medicine is generally low, improving the transdermal efficiency of the effective components of traditional Chinese medicine is particularly important for carrying out the transdermal administration of traditional Chinese medicine. Modern pharmacy can improve the absorption of the effective ingredients of the traditional Chinese medicine on the skin by preparing the effective ingredients of the traditional Chinese medicine into a nano preparation, and provides a preparation process of the following formula for enhancing the efficacy of the formula.
A manufacturing process of a uterus warming patch comprises the following steps:
pulverizing the raw materials with ultramicro-nanometer powder, and filtering with ultrafiltration membrane with pore diameter of 0.001-0.01 μm to obtain nanopowder and residue; heating Vaseline into liquid, stirring and mixing the Vaseline liquid and the nano powder, wherein the ratio of the Vaseline liquid to the nano powder is 1 mL/g, cooling to obtain an ointment, adding the ointment onto a non-woven fabric blank patch, wherein the mass of the ointment is 5-10g, covering the non-woven fabric blank patch added with the ointment with paper, and refrigerating and storing at the temperature of 2-10 ℃.
The raw materials are crushed into nano powder to prepare the patch which has good absorption performance and high bioavailability, can be used for treating or assisting in treating chronic and easily-recurrent dysmenorrhea for a long time, makes up the defects of bitter taste, high price, difficult decoction and the like of traditional Chinese medicine decoction, exerts the advantages of the traditional Chinese medicine acupoint patch, can fully utilize the medicine, exerts the medicine effect to the greatest extent and ensures the treatment effectiveness. The solid lipid nanoparticles can form a film on the surface of skin because a high-concentration surfactant is not used in the preparation process, promote the absorption of the medicament through the hydration of epidermis after partial sealing, and increase the contact time and the area of the medicament and the horny layer, thereby being beneficial to the percutaneous absorption of the medicament.
In the embodiment, the method also comprises the steps of adding ethanol into the filter residue, carrying out reflux extraction at 60-80 ℃ for 30-50min, then filtering, centrifuging at 800-1000r/min for 5-10min, concentrating until the water content of the thick paste is 20-30% to obtain thick paste, and then stirring and mixing the thick paste with vaseline liquid and nano powder.
The filter residue has larger grain diameter, so that the filter residue is directly prepared into ointment which is not beneficial to percutaneous absorption, and the effective components in the filter residue are extracted and then mixed with the nano powder, thereby not only enhancing the content of the effective components of the medicament, but also enhancing the medicament absorption, improving the bioavailability of the medicament and leading the patch to have better treatment effect on dysmenorrheal and cold womb.
The features and properties of the present application are described in further detail below with reference to examples.
Example 1
A manufacturing process of a uterus warming patch comprises the following steps:
raw materials: 10g of Chinese angelica, 10g of ligusticum wallichii, 5g of red peony root, 10g of cattail pollen, 7g of trogopterus dung, 12g of corydalis tuber, 7g of myrrh, 5g of cinnamon, 5g of dried ginger, 8g of fennel, 12g of folium artemisiae argyi, 7g of szechwan chinaberry fruit, 5g of safflower, 12g of eucommia bark and 7g of liquorice.
Pulverizing the raw materials by ultra-micro nanometer, and filtering with ultrafiltration membrane with pore diameter of 0.005 μm to obtain nanopowder and filter residue; heating Vaseline into liquid, stirring and mixing the Vaseline liquid and the nano powder, wherein the ratio of the Vaseline liquid to the nano powder is 1 mL/g, cooling to obtain an ointment, adding the ointment onto a non-woven fabric blank patch, wherein the mass of the ointment is 8g, covering the non-woven fabric blank patch added with the ointment with paper, and refrigerating and storing at the temperature of 5 ℃.
Example 2
A manufacturing process of a uterus warming patch comprises the following steps:
raw materials: 8g of Chinese angelica, 8g of ligusticum wallichii, 3g of red peony root, 8g of pollen typhae, 5g of trogopterus dung, 10g of corydalis tuber, 6g of myrrh, 3g of cinnamon, 3g of dried ginger, 7g of fennel, 10g of folium artemisiae argyi, 5g of szechwan chinaberry fruit, 3g of safflower, 10g of eucommia bark and 5g of liquorice.
Pulverizing the raw materials by ultra-micro nanometer, and filtering with ultrafiltration membrane with pore diameter of 0.001 μm to obtain nanopowder and filter residue; heating Vaseline into liquid, stirring and mixing the Vaseline liquid and the nano powder, wherein the ratio of the Vaseline liquid to the nano powder is 1 mL/g, cooling to obtain an ointment, adding the ointment onto a non-woven fabric blank patch, wherein the mass of the ointment is 5g, covering the non-woven fabric blank patch added with the ointment with paper, and refrigerating and storing at the temperature of 2 ℃.
Example 3
A manufacturing process of a uterus warming patch comprises the following steps:
raw materials: 12g of Chinese angelica, 12g of ligusticum wallichii, 8g of red peony root, 12g of pollen typhae, 8g of trogopterus dung, 15g of corydalis tuber, 8g of myrrh, 7g of cinnamon, 7g of dried ginger, 11g of fennel, 15g of folium artemisiae argyi, 8g of szechwan chinaberry fruit, 8g of safflower, 15g of eucommia bark and 9g of liquorice.
Pulverizing the raw materials by ultra-micro nanometer, and filtering with ultrafiltration membrane with pore diameter of 0.01 μm to obtain nanopowder and filter residue; heating Vaseline into liquid, stirring and mixing the Vaseline liquid and the nano powder, wherein the ratio of the Vaseline liquid to the nano powder is 1 mL/g, cooling to obtain an ointment, adding the ointment to a non-woven fabric blank patch, wherein the mass of the ointment is 10g, covering the non-woven fabric blank patch added with the ointment with paper, and refrigerating and storing at the temperature of 10 ℃.
Example 4
A manufacturing process of a uterus warming patch comprises the following steps:
raw materials: 9g of Chinese angelica, 11g of ligusticum wallichii, 7g of red peony root, 9g of pollen typhae, 7g of trogopterus dung, 13g of corydalis tuber, 7g of myrrh, 4g of cinnamon, 4g of dried ginger, 8g of fennel, 13g of folium artemisiae argyi, 7g of szechwan chinaberry fruit, 6g of safflower, 11g of eucommia bark and 8g of liquorice.
Pulverizing raw materials by ultra-micro nanometer, filtering with ultrafiltration membrane with pore diameter of 0.008 μm to obtain nanopowder and residue, adding ethanol into the residue, reflux-extracting at 70 deg.C for 40min, filtering, centrifuging at 900r/min for 8min, and concentrating to water content of 22% to obtain soft extract; heating Vaseline into liquid, stirring and mixing the Vaseline liquid, the thick paste and the nano powder, wherein the ratio of the Vaseline liquid to the nano powder is 1 mL/g to 3mL/g, cooling to obtain an ointment, adding the ointment onto a non-woven fabric blank patch, wherein the mass of the ointment is 7g, covering the non-woven fabric blank patch added with the ointment with paper, and refrigerating and storing at the temperature of 7 ℃.
Test results
500 female volunteers with dysmenorrhea symptoms were selected, aged 18-40 years, and randomly divided into 5 groups, each group containing 100 persons, 1-4 groups respectively using the uterus warming patch of example 1-4, and 5 groups as control group, using modified folium Artemisiae Argyi warming patch (trade name: 10046022976732), and all using methods were to apply the patch to navel for 10h each time, and using time is 6 months. After the application, the results are recorded according to the use feeling of the testee and the improvement condition of dysmenorrheal and cold uterus, and are as follows:
TABLE 1 dysmenorrhoea results
| Group of | No reduction of dysmenorrhea/%) | Slightly alleviating/% | Reduction of dysmenorrhea/%) | Significant reduction/% of dysmenorrhea |
| 1 | 5 | 4 | 6 | 85 |
| 2 | 4 | 2 | 12 | 82 |
| 3 | 5 | 3 | 11 | 81 |
| 4 | 1 | 3 | 6 | 90 |
| 5 | 30 | 20 | 10 | 40 |
As can be seen from table 1, the uterus warming patches of examples 1-4 can significantly alleviate dysmenorrhea conditions compared to the control group. The uterus warming patch prepared by the embodiment of the application has a good treatment effect on dysmenorrhea.
TABLE 2 results of cold uterus
As can be seen from table 2, the uterus warming patches of examples 1-4 can significantly improve the cold condition of the uterus compared to the control group. The uterus warming patch prepared by the embodiment of the application has a good treatment effect on cold in uterus.
Table 3 results of the usage test
| Group of | Alleviating effect/score of dysmenorrhea | Improving action/minute of uterus cold | Comfort/point of use |
| 1 | 8.5 | 8 | 8.5 |
| 4 | 9.5 | 9 | 8.5 |
| 5 | 4 | 3 | 8 |
The above-mentioned score is the average score of each group, preferably 10 scores, the worst score is 0 score, and so on.
As can be seen from table 3, the uterus warming patch prepared in the example has better relief effect on dysmenorrhea and better improvement effect on cold in uterus compared with the control group. The application shows that the medicine has better uterus warming and pain relieving effects.
In summary, the uterus warming patch of the embodiment of the application has the curative effects of activating blood circulation, removing blood stasis, warming meridians and relieving pain, and the medicine is absorbed into viscera and meridians through skin local transdermal absorption, so that the decomposition effect of liver and gastrointestinal tract is avoided, and the utilization rate of the medicine is fully improved. In the prescription, angelica, rhizoma ligustici wallichii, cattail pollen and trogopterus dung are used as monarch drugs, and the effects of activating blood circulation, removing stasis and relieving pain are achieved; cinnamon, dried ginger, fennel and folium artemisiae argyi are used as ministerial drugs and have the effects of warming uterus and relieving pain, and safflower is used as a ministerial drug and can strengthen the effects of promoting blood circulation and removing blood stasis of the ministerial drugs; corydalis tuber and szechwan chinaberry fruit are adjuvant drugs, promote qi circulation to relieve pain, and strengthen the analgesic property of monarch drugs and ministerial drugs; myrrh is an adjuvant drug, which promotes blood circulation to relieve pain and strengthens the effect of relieving pain; the red paeony root is an adjuvant drug, promotes blood circulation to remove blood stasis, and prevents the medicines from being over warm; eucommia bark is used as an adjuvant drug, so that the kidney is nourished and the waist is strengthened to relieve pain, and the warm tonifying property is strengthened; licorice root, radix Glycyrrhizae is used as a guiding drug to coordinate the effects of the other drugs in the recipe, and is prepared with honey to enhance the tonifying effect. The prescription has proper compatibility, accurate dosage and obvious clinical curative effect, and is prepared into a paste acupoint plaster for treating some chronic and refractory diseases, and is particularly suitable for female patients with frequent dysmenorrhea. In addition, the acupoint application therapy has a long development history, wide application range, definite clinical curative effect, safety, reliability, stable medicine property, no special smell, convenient storage and low carrying cost.
According to the preparation process of the uterus warming patch provided by the embodiment of the application, the patch which has good absorption performance and high bioavailability and can be used for treating or assisting in treating chronic and easily-recurrent dysmenorrhea for a long time is prepared by crushing raw materials into nano powder, so that the defects of bitter taste, high price, difficulty in decocting and the like of traditional Chinese medicine decoction are overcome, the advantages of the traditional Chinese medicine acupoint patch are exerted, the medicine can be fully utilized, the medicine effect is exerted to the maximum degree, and the treatment effectiveness is ensured. The solid lipid nanoparticles can form a film on the skin surface because a high-concentration surfactant is not used in the preparation process, promote the drug absorption through the epidermis hydration after the local sealing, and increase the contact time and the area of the drug and the horny layer, thereby being beneficial to the percutaneous absorption of the drug.
The embodiments described above are some, but not all embodiments of the present application. The detailed description of the embodiments of the present application is not intended to limit the scope of the claimed application, but is merely representative of selected embodiments of the application. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.
Claims (10)
1. The uterus warming patch is characterized by comprising the following raw materials in parts by weight: 6-15 parts of angelica sinensis, 6-15 parts of ligusticum wallichii, 3-10 parts of red paeony root, 5-15 parts of pollen typhae, 5-10 parts of trogopterus dung, 5-20 parts of rhizoma corydalis, 6-10 parts of myrrh, 3-9 parts of cinnamon, 3-9 parts of dried ginger, 5-15 parts of fennel, 5-20 parts of folium artemisiae argyi, 5-10 parts of szechwan chinaberry fruit, 3-10 parts of safflower, 5-15 parts of eucommia ulmoides and 3-9 parts of liquorice.
2. The uterus warming patch as claimed in claim 1, which comprises, by weight, 8-12 parts of angelica sinensis, 8-12 parts of ligusticum wallichii, 3-8 parts of radix paeoniae rubra, 8-12 parts of pollen typhae, 5-8 parts of trogopterus dung, 10-15 parts of rhizoma corydalis, 6-8 parts of myrrh, 3-7 parts of cinnamon, 3-7 parts of rhizoma zingiberis, 7-11 parts of fennel, 10-15 parts of folium artemisiae argyi, 5-8 parts of fructus toosendan, 3-8 parts of safflower carthamus, 10-15 parts of eucommia ulmoides and 5-9 parts of liquorice.
3. The uterus warming patch as claimed in claim 2, which comprises, by weight, 10 parts of angelica sinensis, 10 parts of ligusticum wallichii, 5 parts of radix paeoniae rubra, 10 parts of pollen typhae, 7 parts of trogopterus dung, 12 parts of rhizoma corydalis, 7 parts of myrrh, 5 parts of cinnamon, 5 parts of rhizoma zingiberis, 8 parts of fennel, 12 parts of folium artemisiae argyi, 7 parts of fructus toosendan, 5 parts of safflower, 12 parts of eucommia ulmoides and 7 parts of liquorice.
4. A process for making a uterus warming patch according to any one of claims 1-3, comprising the steps of:
crushing the raw materials by adopting an ultra-micro nano powder to obtain nano powder; heating Vaseline to obtain liquid, mixing Vaseline liquid and nanometer powder, cooling to obtain unguent, adding unguent to the non-woven fabric blank patch, covering the non-woven fabric blank patch with paper, and refrigerating for storage.
5. The manufacturing process of the uterus warming patch according to claim 4, wherein after the ultramicro pulverization, the filtration is carried out by adopting an ultrafiltration membrane with the aperture of 0.001-0.01 μm to obtain the nano powder and the filter residue.
6. The manufacturing process of the uterus warming patch according to claim 5, further comprising adding ethanol into the filter residue for reflux extraction, then filtering, centrifuging, concentrating to obtain a thick paste, and then stirring and mixing the thick paste with vaseline liquid and nano powder.
7. The preparation method of uterus warming patch according to claim 6, wherein the reflux extraction is performed at 60-80 deg.C for 30-50min, the centrifugation is performed at 800-1000r/min for 5-10min, and the concentration is performed until the water content of the thick paste is 20-30%.
8. The manufacturing process of the uterus warming patch as claimed in claim 4, wherein the ratio of the vaseline liquid to the nano powder is 1 ml/g.
9. The manufacturing process of the uterus warming plaster as claimed in claim 4, wherein the mass of the ointment added to the non-woven fabric blank plaster is 5-10g.
10. The manufacturing process of the uterus warming patch as claimed in claim 4, wherein the refrigerating preservation temperature is 2-10 ℃.
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Citations (3)
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| CN1365750A (en) * | 2001-01-19 | 2002-08-28 | 杨孟君 | Nano medicine 'Shaofu Zhuyu' and its preparing process |
| CN109331159A (en) * | 2018-11-15 | 2019-02-15 | 谈宗华 | A kind of gel emplastrum and preparation method thereof for treating dysmenorrhea |
| CN113058020A (en) * | 2021-03-05 | 2021-07-02 | 哈尔滨商业大学 | Navel patch for regulating menstruation and preparation method thereof |
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Patent Citations (3)
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|---|---|---|---|---|
| CN1365750A (en) * | 2001-01-19 | 2002-08-28 | 杨孟君 | Nano medicine 'Shaofu Zhuyu' and its preparing process |
| CN109331159A (en) * | 2018-11-15 | 2019-02-15 | 谈宗华 | A kind of gel emplastrum and preparation method thereof for treating dysmenorrhea |
| CN113058020A (en) * | 2021-03-05 | 2021-07-02 | 哈尔滨商业大学 | Navel patch for regulating menstruation and preparation method thereof |
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