CN115300478A - Soft capsule oil seal probiotic tabletting and preparation method thereof - Google Patents
Soft capsule oil seal probiotic tabletting and preparation method thereof Download PDFInfo
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- CN115300478A CN115300478A CN202210985361.0A CN202210985361A CN115300478A CN 115300478 A CN115300478 A CN 115300478A CN 202210985361 A CN202210985361 A CN 202210985361A CN 115300478 A CN115300478 A CN 115300478A
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/20—Agglomerating; Granulating; Tabletting
- A23P10/28—Tabletting; Making food bars by compression of a dry powdered mixture
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- A23P10/00—Shaping or working of foodstuffs characterised by the products
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Abstract
The invention discloses a soft capsule oil seal probiotic tabletting and a preparation method thereof, wherein the soft capsule oil seal probiotic tabletting comprises an olive-shaped soft capsule body, a solid probiotic tabletting is arranged in the olive-shaped soft capsule body, and a soft capsule oil liquid is filled in a gap between the solid probiotic tabletting and the olive-shaped soft capsule body; firstly, carrying out primary mixing on a probiotic tabletting raw material to obtain a primary mixed raw material; step two, mixing the primary mixed raw materials obtained in the step one again to obtain mixed raw materials; step three, granulating and tabletting the mixed raw materials obtained in the step two; step four, drying and shaping the granulated raw materials; step five, preparing the soft capsule oil; step six, preparing an olive soft capsule body; step seven, opening the soft capsule, tabletting the solid probiotics into the soft capsule, and injecting the capsule oil into the soft capsule; the invention can completely isolate the thallus from contacting with the air, avoid the thallus from contacting with the moisture in the air and keep the activity of the thallus to the maximum extent.
Description
Technical Field
The invention relates to the field of probiotic tabletting processing, in particular to a soft capsule oil seal probiotic tabletting and a preparation method thereof.
Background
The probiotics are bacteria which can promote the health of human bodies, and the common probiotics comprise lactobacillus, bifidobacterium, streptococcus and the like. The organic acid, polysaccharide, hydrogen peroxide, bacteriocin and special enzyme system generated by the probiotics have the effects of regulating the balance of gastrointestinal flora, improving immunity, delaying senility, improving constipation, diarrhea and allergic symptoms and the like. Therefore, various probiotics are widely added into dairy products, meat products, fruit and vegetable products, medical and health products and the like at present, and active probiotics are health products which are very popular at present. The product forms are mainly solid beverage bar bag and hard capsule and pressed product
Chinese patent discloses a tablet with high probiotic activity and a preparation method and application thereof (No. CN 110960560B), the patent technology adopts proper auxiliary materials and proper granulating steps, tablets with relatively high mechanical strength and hardness can be pressed by small pressure, and the anti-moisture absorption environment around the probiotic can be kept, so that the characteristic that the activity of active probiotics is lost when being pressed is adapted, and the viable bacteria loss of the tablet product in the preparation process is greatly reduced; meanwhile, the living environment of probiotics in the tablet is improved, the moisture absorption resistance of the tablet product is enhanced, the viable bacteria content of the tablet product in the shelf life is prolonged, but the capsule, the tablet and the tablet of the existing product can not be in contact with the air completely, and the probiotics can be quickly inactivated when contacting with the moisture in the air, so that the freeze-dried bacteria can be slowly inactivated. Therefore, the person skilled in the art provides a soft capsule oil-sealed probiotic tabletting and a preparation method thereof, so as to solve the problems in the background art.
Disclosure of Invention
In order to solve the technical problem, the invention provides a soft capsule oil seal probiotic tabletting which comprises an olive-shaped soft capsule body, wherein a solid probiotic tabletting is arranged in the olive-shaped soft capsule body, and soft capsule oil is filled in a gap between the solid probiotic tabletting and the olive-shaped soft capsule body.
Preferably: the solid probiotic tablet is in any one of a round shape, a strip shape or a granular shape.
Preferably, the following components: the oil of the soft capsule is dissolved fat-soluble oil, and the components of the oil of the soft capsule are vitamin E and phosphatidylserine.
A preparation method of a soft capsule oil seal probiotic tablet comprises the following specific steps;
firstly, carrying out primary mixing on a probiotic tabletting raw material to obtain a primary mixed raw material;
step two, mixing the primary mixed raw materials obtained in the step one again to obtain mixed raw materials;
step three, granulating and tabletting the mixed raw materials obtained in the step two;
drying and shaping the granulated raw materials to obtain solid probiotic tablets with corresponding shapes;
step five, preparing the soft capsule oil, mixing the natural vitamin E and the phosphatidylserine for 30min, uniformly mixing, grinding for three times through a colloid mill, and removing bubbles in vacuum; under the vacuum degree of-0.10 MPa and the temperature: degassing at 90-100 deg.c for 2 hr to obtain soft capsule oil;
step six, preparing olive type soft capsule bodies, namely weighing the gelatin, the glycerol and the water according to the weight ratio of the gelatin to the water = 2; soaking gelatin in 80% water to swell it; mixing the rest water with glycerol, heating to 70 deg.C in a gelatin boiling pot, adding gelatin solution, stirring to completely melt for 1-1.5 hr, adding curcumin, stirring, cooling, standing at 60 deg.C, removing floating foam, filtering to obtain gelatin solution, making into soft capsule at 18-22 deg.C and 35-45% relative humidity in a soft capsule pelleting machine, and making into soft capsule at 250-300 mg/capsule;
step seven, opening the soft capsules, tabletting the solid probiotics into the soft capsules, injecting the capsule oil into the soft capsules, and sealing the soft capsules by a sealing machine;
step eight, shaping and reshaping the soft capsule prepared in the step 7, blowing the pressed soft capsule in a net machine at 20 ℃ for shaping, shaping for 4 hours, washing off an oil layer on the surface of the soft capsule by using ethanol in a pill washing machine, drying the washing liquid, drying and airing the pill, and drying the ethanol-washed soft capsule in the net machine for about 6 hours;
step nine, picking pills: manually picking the dried soft capsules or mechanically picking the soft capsules, picking large pills, special-shaped pills, obvious screen-printed pills, leakage pills, shriveled pills, thin-walled pills, bubble pills and the like, putting the qualified soft capsules into a clean and dry container, weighing, attaching state marks outside the container to mark the name, weight, batch number and date of the product, capping by using a stainless steel barrel, sealing and then sending the soft capsules to an intermediate station;
step ten, inspecting and packaging: inspecting the soft capsule, and packaging.
Preferably: the first step is that 2 to 6 parts of probiotic freeze-dried powder, 2 to 4 parts of porous starch, 0.5 to 1.5 parts of puffed corn flour, 20 to 40 parts of skim milk powder and 35 to 40 parts of adhesive are added into a mixer according to the parts by weight, the rotating speed is 2000r/min, the temperature is 20 ℃, and the mixture is stirred and mixed for 20min.
Preferably: and the second step is to add 10 to 15 parts of fructo-oligosaccharide and 20 to 30 parts of maltodextrin in parts by weight into a mixer, rotate at a speed of 3000r/min and at a temperature of 20 ℃, and stir and mix for 20min.
Preferably: and step three, specifically, sieving the mixed raw materials through a 18-mesh sieve for granulation, sieving the crushed raw materials through a 16-mesh sieve for size stabilization, and putting the whole plums into a tablet machine for tablet pressing and forming to obtain a semi-finished product.
Preferably: the fourth step is that the semi-finished product is put into a drying oven with the temperature of 40-50 ℃ to be dried for 40-50 min; and (3) drying the product in a drying chamber for 8-9 h until the water content is less than or equal to 0.1%, thus obtaining the solid probiotic tabletting.
The invention has the technical effects and advantages that:
the invention can completely isolate the thallus from contacting with the air, avoids the thallus from contacting with the moisture in the air, keeps the activity of the thallus to the maximum, has beautiful product shape and strong value feeling, can contain different components in the same product as much as possible, and also contains water-soluble and fat-soluble effective components.
Drawings
Fig. 1 is a schematic structural diagram of a soft capsule oil-sealed probiotic tablet provided by an embodiment of the application;
in the figure: 1. an olive-type soft capsule body; 2. soft capsule oil; 3. and (4) tabletting the solid probiotics.
Detailed Description
The present invention will be described in further detail with reference to the accompanying drawings and specific embodiments. The embodiments of the present invention have been presented for purposes of illustration and description, and are not intended to be exhaustive or limited to the invention in the form disclosed. Many modifications and variations will be apparent to those of ordinary skill in the art. The embodiment was chosen and described in order to best explain the principles of the invention and the practical application, and to enable others of ordinary skill in the art to understand the invention for various embodiments with various modifications as are suited to the particular use contemplated.
Example 1
Referring to fig. 1, the embodiment provides a soft capsule oil-sealed probiotic tablet, which includes an olive-shaped soft capsule body 1, a solid probiotic tablet 3 is disposed in the olive-shaped soft capsule body 1, and a gap between the solid probiotic tablet 3 and the olive-shaped soft capsule body 1 is filled with a soft capsule oil 2.
In this embodiment: the solid probiotic tabletting 3 is in any one of a round shape, a strip shape or a granular shape.
In this embodiment: the soft capsule oil liquid 2 is dissolved fat-soluble oil liquid, and the components of the soft capsule oil liquid are vitamin E and phosphatidylserine.
A preparation method of a soft capsule oil seal probiotic tablet comprises the following specific steps;
firstly, carrying out primary mixing on a probiotic tabletting raw material, adding 2 parts of probiotic freeze-dried powder, 2 parts of porous starch, 0.5 part of puffed corn flour, 20 parts of skim milk powder and 35 parts of adhesive into a mixer according to parts by weight, stirring and mixing at the rotation speed of 2000r/min and the temperature of 20 ℃ for 20min to obtain a primary mixed raw material;
step two, mixing the primary mixed raw materials obtained in the step one again, adding 10 parts by weight of fructo-oligosaccharide and 20 parts by weight of maltodextrin into a mixer, stirring and mixing at the rotation speed of 3000r/min and the temperature of 20 ℃ for 20min to obtain mixed raw materials;
step three, granulating and tabletting the mixed raw material obtained in the step two, sieving the mixed raw material with a 18-mesh sieve for granulation, sieving the crushed mixed raw material with a 16-mesh sieve for size stabilization, and putting the whole plums into a tabletting machine for tabletting and forming to obtain a semi-finished product;
step four, drying and shaping the granulated raw materials to obtain solid probiotic tablets 3 with corresponding shapes, and drying the semi-finished product in a drying oven at 40 ℃ for 40min; putting the product into a drying chamber for drying for 8 hours until the water content is less than or equal to 0.1 percent, and obtaining a solid probiotic tabletting 3;
step five, preparing the soft capsule oil liquid 2, mixing the natural vitamin E and the phosphatidylserine for 30min, uniformly mixing, grinding for three times through a colloid mill, and removing bubbles in vacuum; under the vacuum degree of-0.10 MPa and at the temperature: degassing at 90 deg.C for 2 hr to obtain soft capsule oil 2;
step six, preparing the olive soft capsule 1, weighing the gelatin, the glycerol and the water according to the following weight ratio of the gelatin to the glycerol to the water = 2; soaking gelatin in 80% water to swell it; mixing the rest water with glycerol, heating to 70 deg.C in a gelatin boiling pot, adding gelatin solution, stirring to completely melt for 1 hr, adding curcumin, stirring to mix well, cooling, standing at 60 deg.C, removing floating foam, filtering to obtain gelatin solution, pressing the gelatin solution in a soft capsule pill press to obtain soft capsule with temperature of 18 deg.C and relative humidity of 35% to obtain soft capsule of 250-300 mg/pill;
step seven, opening the soft capsule, putting the solid probiotic tabletting 3 into the soft capsule, injecting the capsule oil into the soft capsule, and sealing the soft capsule by a sealing machine;
step eight, shaping and reshaping the soft capsules prepared in the step 7, blowing the pressed soft capsules in a net machine at 20 ℃ for shaping, shaping for 4 hours, washing off an oil layer on the surfaces of the soft capsules by using an ethanol washing pill machine, blowing washing liquor, drying and drying pills, and blowing the soft capsules washed by the ethanol in the net machine for about 6 hours;
step nine, picking pills: manually picking the dried soft capsules or mechanically picking the soft capsules, picking large pills, special-shaped pills, obvious screen-printed pills, leakage pills, shriveled pills, thin-walled pills, bubble pills and the like, putting the qualified soft capsules into a clean and dry container, weighing, attaching state marks outside the container to mark the name, weight, batch number and date of the product, capping by using a stainless steel barrel, sealing and then sending the soft capsules to an intermediate station;
step ten, inspecting and packaging: inspecting the soft capsule, and packaging.
Example 2
A preparation method of a soft capsule oil seal probiotic tablet comprises the following specific steps;
firstly, primarily mixing probiotic tabletting raw materials, adding 4 parts by weight of probiotic freeze-dried powder, 3 parts by weight of porous starch, 1 part by weight of puffed corn flour, 30 parts by weight of skim milk powder and 38 parts by weight of adhesive into a mixer, stirring and mixing at the rotation speed of 2000r/min and the temperature of 20 ℃ for 20min to obtain primarily mixed raw materials;
step two, mixing the primary mixed raw materials obtained in the step one again, adding 13 parts of fructo-oligosaccharide and 25 parts of maltodextrin in parts by weight into a mixer, stirring and mixing at the rotating speed of 3000r/min and the temperature of 20 ℃ for 20min to obtain mixed raw materials;
step three, granulating and tabletting the mixed raw material obtained in the step two, sieving the mixed raw material with a 18-mesh sieve for granulation, sieving the crushed mixed raw material with a 16-mesh sieve for size stabilization, and putting the whole plums into a tabletting machine for tabletting and forming to obtain a semi-finished product;
step four, drying and shaping the granulated raw materials to obtain solid probiotic tablets 3 with corresponding shapes, and drying the semi-finished product in a 45 ℃ drying oven for 45min; putting the product into a drying chamber for drying for 8.5h until the water content is less than or equal to 0.1 percent, thus obtaining a solid probiotic tabletting 3;
step five, preparing the soft capsule oil liquid 2, mixing the natural vitamin E and the phosphatidylserine for 30min, uniformly mixing, grinding for three times through a colloid mill, and removing bubbles in vacuum; under the vacuum degree of-0.10 MPa and the temperature: degassing at 95 deg.C for 2 hr to obtain soft capsule oil 2;
step six, preparing the olive soft capsule 1, weighing the gelatin, the glycerol and the water according to the following weight ratio of the gelatin to the glycerol to the water = 2; soaking gelatin in 80% water to swell it; mixing the rest water with glycerol, heating to 70 deg.C in a gelatin boiling pot, adding gelatin solution, stirring to completely melt for 1.3 hr, adding curcumin, stirring to mix well, cooling, standing at 60 deg.C, removing floating foam, filtering to obtain gelatin solution, pressing the gelatin solution into soft capsule in a soft capsule pill press at 20 deg.C and 40% relative humidity to obtain soft capsule, 250-300 mg/capsule;
step seven, opening the soft capsule, putting the solid probiotic tabletting 3 into the soft capsule, injecting the capsule oil into the soft capsule, and sealing the soft capsule by a sealing machine;
step eight, shaping and reshaping the soft capsule prepared in the step 7, blowing the pressed soft capsule in a net machine at 20 ℃ for shaping, shaping for 4 hours, washing off an oil layer on the surface of the soft capsule by using ethanol in a pill washing machine, drying the washing liquid, drying and airing the pill, and drying the ethanol-washed soft capsule in the net machine for about 6 hours;
step nine, picking pills: manually picking the dried soft capsules or mechanically picking the soft capsules, picking large pills, special-shaped pills, obvious screen printing pills, leakage pills, shriveled pills, thin-walled pills, bubble pills and the like, putting the qualified soft capsules into a clean and dry container, weighing, attaching a state mark to the outside of the container to mark the name, weight, batch number and date of a product, covering and sealing the container by using a stainless steel barrel, and sending the container to an intermediate station;
step ten, inspecting and packaging: inspecting the soft capsule, and packaging.
Example 3
A preparation method of a soft capsule oil seal probiotic tablet comprises the following specific steps;
firstly, carrying out primary mixing on a probiotic tabletting raw material, adding 6 parts of probiotic freeze-dried powder, 4 parts of porous starch, 1.5 parts of puffed corn flour, 40 parts of skim milk powder and 40 parts of adhesive into a mixer according to parts by weight, stirring and mixing at the rotation speed of 2000r/min and the temperature of 20 ℃ for 20min to obtain a primary mixed raw material;
step two, mixing the primary mixed raw materials obtained in the step one again, adding 15 parts by weight of fructo-oligosaccharide and 30 parts by weight of maltodextrin into a mixer, stirring and mixing at the rotation speed of 3000r/min and the temperature of 20 ℃ for 20min to obtain mixed raw materials;
step three, granulating and tabletting the mixed raw material obtained in the step two, sieving the mixed raw material with a 18-mesh sieve for granulation, sieving the crushed mixed raw material with a 16-mesh sieve for size stabilization, and putting the whole plums into a tabletting machine for tabletting and forming to obtain a semi-finished product;
step four, drying and shaping the granulated raw materials to obtain solid probiotic tablets 3 with corresponding shapes, and drying the semi-finished product in a 50 ℃ drying oven for 50min; putting the product into a drying chamber for drying for 9 hours until the water content is less than or equal to 0.1 percent, and obtaining a solid probiotic tabletting 3;
step five, preparing the soft capsule oil liquid 2, mixing the natural vitamin E and the phosphatidylserine for 30min, uniformly mixing, grinding for three times by a colloid mill, and removing bubbles in vacuum; under the vacuum degree of-0.10 MPa and the temperature: degassing at 100 deg.C for 2 hr to obtain soft capsule oil 2;
step six, preparing the olive soft capsule 1, weighing the gelatin, the glycerol and the water according to the following weight ratio of the gelatin to the glycerol to the water = 2; soaking gelatin in 80% water to swell it; mixing the rest water with glycerol, heating to 70 deg.C in a gelatin boiling pot, adding gelatin solution, stirring to completely melt for 1.5 hr, adding curcumin, stirring to mix well, cooling, standing at 60 deg.C, removing floating foam, filtering to obtain gelatin solution, pressing the gelatin solution into soft capsule in a soft capsule pill press at 22 deg.C and relative humidity of 45% to obtain soft capsule, and making into 250-300 mg/capsule;
step seven, opening the soft capsule, putting the solid probiotic tabletting 3 into the soft capsule, injecting the capsule oil into the soft capsule, and sealing the soft capsule by a sealing machine;
step eight, shaping and reshaping the soft capsules prepared in the step 7, blowing the pressed soft capsules in a net machine at 20 ℃ for shaping, shaping for 4 hours, washing off an oil layer on the surfaces of the soft capsules by using an ethanol washing pill machine, blowing washing liquor, drying and drying pills, and blowing the soft capsules washed by the ethanol in the net machine for about 6 hours;
step nine, picking pills: manually picking the dried soft capsules or mechanically picking the soft capsules, picking large pills, special-shaped pills, obvious screen-printed pills, leakage pills, shriveled pills, thin-walled pills, bubble pills and the like, putting the qualified soft capsules into a clean and dry container, weighing, attaching state marks outside the container to mark the name, weight, batch number and date of the product, capping by using a stainless steel barrel, sealing and then sending the soft capsules to an intermediate station;
step ten, inspecting and packaging: inspecting the soft capsule, and packaging.
The soft capsule oil seal probiotic tabletting prepared in the embodiments 1 to 3 is respectively packaged and then stored at normal temperature, the number of live bacteria of the probiotics in different periods is detected, meanwhile, the number of live bacteria of the probiotics in different periods of the conventional probiotic tabletting and the tablet is detected, and the statistical results are as follows:
as can be seen from the above table, the viable cell counts of the probiotic pellets prepared in the soft capsule oil seal of examples 1-3 were maintained at 5.11 × 10 after 6 months of storage at room temperature 10 After the conventional tablet or the probiotic tablet is stored for 6 months at normal temperature, the number of viable bacteria is 7.23 multiplied by 10 10 Down to 6.85X 10 8 The viable count of the probiotic tablet is obviously reduced, so that the probiotic tablet with the soft capsule oil seal can completely isolate the thallus from contacting with air, avoid the thallus from contacting with moisture in the air and keep the activity of the thallus to the maximum extent.
It is to be understood that the described embodiments are merely a few embodiments of the invention, and not all embodiments. All other embodiments, which can be derived by one of ordinary skill in the art and related arts based on the embodiments of the present invention without any creative effort, shall fall within the protection scope of the present invention. Structures, devices, and methods of operation not specifically described or illustrated herein are generally practiced in the art without specific recitation or limitation.
Claims (8)
1. The probiotic tabletting for the soft capsule oil seal is characterized by comprising an olive type soft capsule body (1), wherein a solid probiotic tabletting (3) is arranged in the olive type soft capsule body (1), and a soft capsule oil liquid (2) is filled in a gap between the solid probiotic tabletting (3) and the olive type soft capsule body (1).
2. The soft capsule oil-seal probiotic tabletting according to claim 1, wherein the solid probiotic tabletting (3) is in any one of a round shape, a strip shape or a granular shape.
3. The probiotic tabletting through oil sealing with soft capsules as claimed in claim 1, wherein the soft capsule oil (2) is a dissolved fat-soluble oil, and the ingredients of the oil are vitamin E and phosphatidylserine.
4. The preparation method of the soft capsule oil-sealed probiotic tablet according to any one of claims 1 to 3, which is characterized by comprising the following specific steps;
firstly, performing primary mixing on a probiotic tabletting raw material to obtain a primary mixed raw material;
step two, mixing the primary mixed raw materials obtained in the step one again to obtain mixed raw materials;
step three, granulating and tabletting the mixed raw materials obtained in the step two;
step four, drying and shaping the granulated raw materials to obtain solid probiotic tabletting (3) with corresponding shapes;
step five, preparing the soft capsule oil liquid (2), mixing the natural vitamin E and the phosphatidylserine for 30min, uniformly mixing, grinding for three times through a colloid mill, and removing bubbles in vacuum; under the vacuum degree of-0.10 MPa and at the temperature: degassing at 90-100 ℃ for 2 hours to obtain soft capsule oil (2);
step six, preparing the olive type soft capsule (1), namely weighing the gelatin, the glycerol and the water according to the weight ratio of the gelatin to the glycerol to the water = 2; soaking gelatin in 80% water to swell it; mixing the rest water with glycerol, heating to 70 deg.C in a gelatin boiling pot, adding gelatin solution, stirring to completely melt for 1-1.5 hr, adding curcumin, stirring, cooling, standing at 60 deg.C, removing floating foam, filtering to obtain gelatin solution, making into soft capsule at 18-22 deg.C and 35-45% relative humidity in a soft capsule pelleting machine, and making into soft capsule at 250-300 mg/capsule;
step seven, opening the soft capsule, putting the solid probiotic tabletting (3) into the soft capsule, injecting the capsule oil into the soft capsule, and sealing the soft capsule by a sealing machine;
step eight, shaping and reshaping the soft capsules prepared in the step 7, blowing the pressed soft capsules in a net machine at 20 ℃ for shaping, shaping for 4 hours, washing off an oil layer on the surfaces of the soft capsules by using an ethanol washing pill machine, blowing washing liquor, drying and drying pills, and blowing the soft capsules washed by the ethanol in the net machine for about 6 hours;
step nine, picking pills: manually picking the dried soft capsules or mechanically picking the soft capsules, picking large pills, special-shaped pills, obvious screen-printed pills, leakage pills, shriveled pills, thin-walled pills, bubble pills and the like, putting the qualified soft capsules into a clean and dry container, weighing, attaching state marks outside the container to mark the name, weight, batch number and date of the product, capping by using a stainless steel barrel, sealing and then sending the soft capsules to an intermediate station;
step ten, inspecting and packaging: inspecting the soft capsule, and packaging.
5. The preparation method of the probiotic tabletting for the soft capsule oil seal according to claim 4, wherein the first step is to add 2-6 parts by weight of probiotic freeze-dried powder, 2-4 parts by weight of porous starch, 0.5-1.5 parts by weight of puffed corn flour, 20-40 parts by weight of skimmed milk powder and 35-40 parts by weight of adhesive into a mixer at a rotation speed of 2000r/min and a temperature of 20 ℃ for stirring and mixing for 20min.
6. The probiotic tabletting and the preparation method thereof according to claim 4, wherein the second step is to add 10-15 parts of fructo-oligosaccharide and 20-30 parts of maltodextrin by weight into a mixer, rotate at 3000r/min and 20 ℃ for 20min by stirring and mixing.
7. The soft capsule oil seal probiotic tabletting and the preparation method thereof as claimed in claim 4, wherein the third step is specifically to pass the mixed raw material through a 18-mesh sieve for granulation, pass through a 16-mesh sieve for granulation after crushing, and put the whole plum into a tabletting machine for tabletting forming to obtain a semi-finished product.
8. The soft capsule oil seal probiotic tabletting and the preparation method thereof according to claim 4, wherein the fourth step is to dry the semi-finished product in an oven at 40-50 ℃ for 40-50 min; and (4) putting the product into a drying chamber for drying for 8-9 h, wherein the water content is less than or equal to 0.1%, and obtaining the solid probiotic tabletting (3).
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Application publication date: 20221108 |