CN115299543B - Solid beverage for promoting human dopamine anabolism and preparation method thereof - Google Patents
Solid beverage for promoting human dopamine anabolism and preparation method thereof Download PDFInfo
- Publication number
- CN115299543B CN115299543B CN202210968100.8A CN202210968100A CN115299543B CN 115299543 B CN115299543 B CN 115299543B CN 202210968100 A CN202210968100 A CN 202210968100A CN 115299543 B CN115299543 B CN 115299543B
- Authority
- CN
- China
- Prior art keywords
- powder
- solid beverage
- anabolism
- red date
- dopamine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 title claims abstract description 80
- 239000007787 solid Substances 0.000 title claims abstract description 64
- 235000013361 beverage Nutrition 0.000 title claims abstract description 63
- 230000015572 biosynthetic process Effects 0.000 title claims abstract description 45
- 238000002360 preparation method Methods 0.000 title claims abstract description 41
- 229960003638 dopamine Drugs 0.000 title claims abstract description 40
- 230000001737 promoting effect Effects 0.000 title claims abstract description 32
- 239000000843 powder Substances 0.000 claims abstract description 116
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 36
- 239000000203 mixture Substances 0.000 claims abstract description 33
- 235000006886 Zingiber officinale Nutrition 0.000 claims abstract description 30
- 235000008397 ginger Nutrition 0.000 claims abstract description 30
- 238000002156 mixing Methods 0.000 claims abstract description 21
- 239000005714 Chitosan hydrochloride Substances 0.000 claims abstract description 20
- 238000003756 stirring Methods 0.000 claims abstract description 17
- 238000001035 drying Methods 0.000 claims abstract description 13
- 150000001413 amino acids Chemical class 0.000 claims abstract description 10
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 10
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 10
- 235000003599 food sweetener Nutrition 0.000 claims abstract description 9
- 239000003765 sweetening agent Substances 0.000 claims abstract description 9
- MNQZXJOMYWMBOU-VKHMYHEASA-N D-glyceraldehyde Chemical compound OC[C@@H](O)C=O MNQZXJOMYWMBOU-VKHMYHEASA-N 0.000 claims abstract description 8
- 239000000080 wetting agent Substances 0.000 claims abstract description 8
- 239000000706 filtrate Substances 0.000 claims abstract description 7
- 238000001914 filtration Methods 0.000 claims abstract description 7
- 238000007873 sieving Methods 0.000 claims abstract description 7
- 210000002969 egg yolk Anatomy 0.000 claims abstract description 5
- 239000002994 raw material Substances 0.000 claims abstract description 5
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims abstract description 4
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims abstract description 4
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims abstract description 4
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims abstract description 4
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 46
- 229920001661 Chitosan Polymers 0.000 claims description 39
- 239000000243 solution Substances 0.000 claims description 38
- 239000001103 potassium chloride Substances 0.000 claims description 23
- 235000011164 potassium chloride Nutrition 0.000 claims description 23
- 241000283690 Bos taurus Species 0.000 claims description 15
- 239000007864 aqueous solution Substances 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 9
- 108010038807 Oligopeptides Proteins 0.000 claims description 9
- 102000015636 Oligopeptides Human genes 0.000 claims description 9
- 229940024606 amino acid Drugs 0.000 claims description 9
- 235000001014 amino acid Nutrition 0.000 claims description 9
- 235000018102 proteins Nutrition 0.000 claims description 9
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 6
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims description 6
- 239000005913 Maltodextrin Substances 0.000 claims description 5
- 229920002774 Maltodextrin Polymers 0.000 claims description 5
- 229940035034 maltodextrin Drugs 0.000 claims description 5
- AZKVWQKMDGGDSV-BCMRRPTOSA-N Genipin Chemical compound COC(=O)C1=CO[C@@H](O)[C@@H]2C(CO)=CC[C@H]12 AZKVWQKMDGGDSV-BCMRRPTOSA-N 0.000 claims description 4
- 102000006395 Globulins Human genes 0.000 claims description 4
- 108010044091 Globulins Proteins 0.000 claims description 4
- AZKVWQKMDGGDSV-UHFFFAOYSA-N genipin Natural products COC(=O)C1=COC(O)C2C(CO)=CCC12 AZKVWQKMDGGDSV-UHFFFAOYSA-N 0.000 claims description 4
- 238000003786 synthesis reaction Methods 0.000 claims description 4
- KWTQSFXGGICVPE-UHFFFAOYSA-N 2-amino-5-(diaminomethylideneamino)pentanoic acid;hydron;chloride Chemical compound Cl.OC(=O)C(N)CCCN=C(N)N KWTQSFXGGICVPE-UHFFFAOYSA-N 0.000 claims description 3
- WBZFUFAFFUEMEI-UHFFFAOYSA-M Acesulfame k Chemical compound [K+].CC1=CC(=O)[N-]S(=O)(=O)O1 WBZFUFAFFUEMEI-UHFFFAOYSA-M 0.000 claims description 3
- 108010011485 Aspartame Proteins 0.000 claims description 3
- 102000008186 Collagen Human genes 0.000 claims description 3
- 108010035532 Collagen Proteins 0.000 claims description 3
- CKLJMWTZIZZHCS-UHFFFAOYSA-N D-OH-Asp Natural products OC(=O)C(N)CC(O)=O CKLJMWTZIZZHCS-UHFFFAOYSA-N 0.000 claims description 3
- 239000004386 Erythritol Substances 0.000 claims description 3
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 claims description 3
- 239000004471 Glycine Substances 0.000 claims description 3
- 241000251511 Holothuroidea Species 0.000 claims description 3
- CKLJMWTZIZZHCS-UWTATZPHSA-N L-Aspartic acid Natural products OC(=O)[C@H](N)CC(O)=O CKLJMWTZIZZHCS-UWTATZPHSA-N 0.000 claims description 3
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims description 3
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims description 3
- 229930182816 L-glutamine Natural products 0.000 claims description 3
- BVHLGVCQOALMSV-JEDNCBNOSA-N L-lysine hydrochloride Chemical compound Cl.NCCCC[C@H](N)C(O)=O BVHLGVCQOALMSV-JEDNCBNOSA-N 0.000 claims description 3
- SQVRNKJHWKZAKO-PFQGKNLYSA-N N-acetyl-beta-neuraminic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)O[C@H]1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-PFQGKNLYSA-N 0.000 claims description 3
- 241000237502 Ostreidae Species 0.000 claims description 3
- 244000131316 Panax pseudoginseng Species 0.000 claims description 3
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims description 3
- 235000003140 Panax quinquefolius Nutrition 0.000 claims description 3
- 241001494479 Pecora Species 0.000 claims description 3
- 239000004383 Steviol glycoside Substances 0.000 claims description 3
- 239000004376 Sucralose Substances 0.000 claims description 3
- 235000010358 acesulfame potassium Nutrition 0.000 claims description 3
- 229960004998 acesulfame potassium Drugs 0.000 claims description 3
- 239000000619 acesulfame-K Substances 0.000 claims description 3
- 239000000605 aspartame Substances 0.000 claims description 3
- 235000010357 aspartame Nutrition 0.000 claims description 3
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 claims description 3
- 229960003438 aspartame Drugs 0.000 claims description 3
- 229960005261 aspartic acid Drugs 0.000 claims description 3
- SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 claims description 3
- 210000000988 bone and bone Anatomy 0.000 claims description 3
- 229920001436 collagen Polymers 0.000 claims description 3
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 claims description 3
- 235000019414 erythritol Nutrition 0.000 claims description 3
- 229940009714 erythritol Drugs 0.000 claims description 3
- 235000008434 ginseng Nutrition 0.000 claims description 3
- 229960002989 glutamic acid Drugs 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 3
- 210000003734 kidney Anatomy 0.000 claims description 3
- 210000004185 liver Anatomy 0.000 claims description 3
- 210000004072 lung Anatomy 0.000 claims description 3
- 230000004060 metabolic process Effects 0.000 claims description 3
- 235000020636 oyster Nutrition 0.000 claims description 3
- 210000000952 spleen Anatomy 0.000 claims description 3
- 235000019411 steviol glycoside Nutrition 0.000 claims description 3
- 229930182488 steviol glycoside Natural products 0.000 claims description 3
- 150000008144 steviol glycosides Chemical class 0.000 claims description 3
- 235000019202 steviosides Nutrition 0.000 claims description 3
- 235000019408 sucralose Nutrition 0.000 claims description 3
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 claims description 3
- 244000077995 Coix lacryma jobi Species 0.000 claims description 2
- 102000002322 Egg Proteins Human genes 0.000 claims description 2
- 108010000912 Egg Proteins Proteins 0.000 claims description 2
- 235000013345 egg yolk Nutrition 0.000 claims description 2
- 238000010298 pulverizing process Methods 0.000 claims description 2
- 244000273928 Zingiber officinale Species 0.000 claims 2
- 230000000694 effects Effects 0.000 abstract description 36
- 241000234314 Zingiber Species 0.000 abstract description 28
- 108091000117 Tyrosine 3-Monooxygenase Proteins 0.000 abstract description 20
- 102000048218 Tyrosine 3-monooxygenases Human genes 0.000 abstract description 20
- 102000034238 globular proteins Human genes 0.000 abstract 1
- 108091005896 globular proteins Proteins 0.000 abstract 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 32
- 230000000052 comparative effect Effects 0.000 description 14
- 210000002966 serum Anatomy 0.000 description 12
- 210000004369 blood Anatomy 0.000 description 10
- 239000008280 blood Substances 0.000 description 10
- 238000002474 experimental method Methods 0.000 description 8
- JZLXEKNVCWMYHI-UHFFFAOYSA-N gingerol Natural products CCCCC(O)CC(=O)CCC1=CC=C(O)C(OC)=C1 JZLXEKNVCWMYHI-UHFFFAOYSA-N 0.000 description 7
- 230000002035 prolonged effect Effects 0.000 description 7
- 241001465754 Metazoa Species 0.000 description 6
- 230000029087 digestion Effects 0.000 description 6
- NLDDIKRKFXEWBK-AWEZNQCLSA-N gingerol Chemical compound CCCCC[C@H](O)CC(=O)CCC1=CC=C(O)C(OC)=C1 NLDDIKRKFXEWBK-AWEZNQCLSA-N 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 6
- 238000004088 simulation Methods 0.000 description 6
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 5
- 235000002780 gingerol Nutrition 0.000 description 5
- 238000000338 in vitro Methods 0.000 description 5
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 5
- 102000016267 Leptin Human genes 0.000 description 4
- 108010092277 Leptin Proteins 0.000 description 4
- 241000699670 Mus sp. Species 0.000 description 4
- 239000000654 additive Substances 0.000 description 4
- NRYBAZVQPHGZNS-ZSOCWYAHSA-N leptin Chemical compound O=C([C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(C)C)CCSC)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CS)C(O)=O NRYBAZVQPHGZNS-ZSOCWYAHSA-N 0.000 description 4
- 229940039781 leptin Drugs 0.000 description 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical group CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
- 102100038238 Aromatic-L-amino-acid decarboxylase Human genes 0.000 description 3
- 108010035075 Tyrosine decarboxylase Proteins 0.000 description 3
- 210000005064 dopaminergic neuron Anatomy 0.000 description 3
- 230000035622 drinking Effects 0.000 description 3
- 210000004051 gastric juice Anatomy 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 108010073771 Soybean Proteins Proteins 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 238000013329 compounding Methods 0.000 description 2
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 239000003651 drinking water Substances 0.000 description 2
- 235000020188 drinking water Nutrition 0.000 description 2
- 229940002508 ginger extract Drugs 0.000 description 2
- 235000020708 ginger extract Nutrition 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000002858 neurotransmitter agent Substances 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 1
- AIULWNKTYPZYAN-SFHVURJKSA-N (10)-Gingerol Chemical compound CCCCCCCCC[C@H](O)CC(=O)CCC1=CC=C(O)C(OC)=C1 AIULWNKTYPZYAN-SFHVURJKSA-N 0.000 description 1
- BCIWKKMTBRYQJU-INIZCTEOSA-N (8)-Gingerol Chemical compound CCCCCCC[C@H](O)CC(=O)CCC1=CC=C(O)C(OC)=C1 BCIWKKMTBRYQJU-INIZCTEOSA-N 0.000 description 1
- KJPRLNWUNMBNBZ-QPJJXVBHSA-N (E)-cinnamaldehyde Chemical compound O=C\C=C\C1=CC=CC=C1 KJPRLNWUNMBNBZ-QPJJXVBHSA-N 0.000 description 1
- ZEASWHWETFMWCV-UHFFFAOYSA-N 7-O-(2-O-Acetyl-6-O-Methyl-beta-D-glucuronoside)-4',5,7-Trihydroxyflavone Natural products C=1C(O)=C(O)C2=C(O)C(=O)C=C(C3C(CC4=C(O)C=C(O)C=C4O3)OC(=O)C=3C=C(O)C(O)=C(O)C=3)C=C2C=1C1OC2=CC(O)=CC(O)=C2CC1OC(=O)C1=CC(O)=C(O)C(O)=C1 ZEASWHWETFMWCV-UHFFFAOYSA-N 0.000 description 1
- VSDUZFOSJDMAFZ-UHFFFAOYSA-N 8-gingerol Natural products COC(=O)C(N)CC1=CC=CC=C1 VSDUZFOSJDMAFZ-UHFFFAOYSA-N 0.000 description 1
- AIULWNKTYPZYAN-UHFFFAOYSA-N 810gingerol Natural products CCCCCCCCCC(O)CC(=O)CCC1=CC=C(O)C(OC)=C1 AIULWNKTYPZYAN-UHFFFAOYSA-N 0.000 description 1
- IVOMOUWHDPKRLL-KQYNXXCUSA-N Cyclic adenosine monophosphate Chemical compound C([C@H]1O2)OP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=CN=C2N)=C2N=C1 IVOMOUWHDPKRLL-KQYNXXCUSA-N 0.000 description 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 description 1
- WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 description 1
- 240000000759 Lepidium meyenii Species 0.000 description 1
- 235000000421 Lepidium meyenii Nutrition 0.000 description 1
- 244000179886 Moringa oleifera Species 0.000 description 1
- 235000011347 Moringa oleifera Nutrition 0.000 description 1
- 102000057297 Pepsin A Human genes 0.000 description 1
- 108090000284 Pepsin A Proteins 0.000 description 1
- 241000533293 Sesbania emerus Species 0.000 description 1
- 244000126002 Ziziphus vulgaris Species 0.000 description 1
- 230000001195 anabolic effect Effects 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 239000001522 artemisia absinthium l. herb extract Substances 0.000 description 1
- 229940069765 bean extract Drugs 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 238000010382 chemical cross-linking Methods 0.000 description 1
- 229940117916 cinnamic aldehyde Drugs 0.000 description 1
- KJPRLNWUNMBNBZ-UHFFFAOYSA-N cinnamic aldehyde Natural products O=CC=CC1=CC=CC=C1 KJPRLNWUNMBNBZ-UHFFFAOYSA-N 0.000 description 1
- 229940119429 cocoa extract Drugs 0.000 description 1
- 229940109262 curcumin Drugs 0.000 description 1
- 235000012754 curcumin Nutrition 0.000 description 1
- 239000004148 curcumin Substances 0.000 description 1
- 230000006196 deacetylation Effects 0.000 description 1
- 238000003381 deacetylation reaction Methods 0.000 description 1
- VFLDPWHFBUODDF-UHFFFAOYSA-N diferuloylmethane Natural products C1=C(O)C(OC)=CC(C=CC(=O)CC(=O)C=CC=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-UHFFFAOYSA-N 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 230000008451 emotion Effects 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- 229940089161 ginsenoside Drugs 0.000 description 1
- 229930182494 ginsenoside Natural products 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 235000012902 lepidium meyenii Nutrition 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 229940041616 menthol Drugs 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
- 235000020733 paullinia cupana extract Nutrition 0.000 description 1
- 229940111202 pepsin Drugs 0.000 description 1
- 238000011056 performance test Methods 0.000 description 1
- 230000026731 phosphorylation Effects 0.000 description 1
- 238000006366 phosphorylation reaction Methods 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 235000019633 pungent taste Nutrition 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 229940001941 soy protein Drugs 0.000 description 1
- 235000019710 soybean protein Nutrition 0.000 description 1
- 238000002798 spectrophotometry method Methods 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 235000019640 taste Nutrition 0.000 description 1
- 229960003080 taurine Drugs 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 229940119569 wormwood extract Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/385—Concentrates of non-alcoholic beverages
- A23L2/39—Dry compositions
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/175—Amino acids
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/18—Peptides; Protein hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Non-Alcoholic Beverages (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The application relates to the technical field of solid beverage preparation, and particularly discloses a solid beverage for promoting human dopamine anabolism and a preparation method thereof. A solid beverage for promoting dopamine anabolism of human body is prepared from the following raw materials: red date slow release powder, protein peptide premix, yolk globular protein powder, amino acid premix, sweetener and wetting agent; the preparation method of the red date slow-release powder comprises the following steps: adding red date powder, ginger powder and hydroxypropyl methylcellulose into chitosan hydrochloride solution, and stirring and mixing to obtain a mixture A; adding glyceraldehyde into the mixture A, stirring and mixing, filtering and discarding the filtrate, drying, crushing, and sieving with a 80-100 mesh sieve to obtain the red date slow-release powder. The solid beverage for promoting the anabolism of the dopamine in the human body can promote the activity of tyrosine hydroxylase and promote the anabolism of the dopamine.
Description
Technical Field
The application relates to the technical field of solid beverage preparation, in particular to a solid beverage for promoting human dopamine anabolism and a preparation method thereof.
Background
Dopamine (DA for short) is a central neurotransmitter synthesized by dopaminergic neurons and stored in vesicles, which are released by neurons to assist cells in delivering impulses. The central neurotransmitter directly affects the emotion of a person and has the effects of regulating body swing, mental activities, endocrine and vascular activities.
The anabolic processes of dopamine are: tyrosine in blood is taken up by dopaminergic neurons, catalyzed by Tyrosine Hydroxylase (TH) to become L-dopa, and DA is generated under the action of Dopa Decarboxylase (DDC).
In the life of people, solid beverages are increasingly appearing, and are spread throughout the life of people due to their excellent portability relative to liquid beverages. Tyrosine is a common technical means to increase the concentration of DA in blood after eating.
In the related art, a solid beverage mixture comprises 15% of tyrosine, 15% of maca powder, 15% of taurine, 8% of cocoa extract, 6% of cinnamaldehyde oil-embedding powder, 6% of moringa seed powder, 6% of curcumin, 6% of menthol oil-embedding powder, 6% of wormwood extract, 16% of ginsenoside Rg, 4% of macamide, 4% of guarana extract and 6% of coffee bean extract, wherein more tyrosine is added for improving DA concentration in blood.
With respect to the above-mentioned related art, the inventors found that the ability of eating tyrosine to raise the concentration of DA is limited because the content and activity of TH in dopaminergic neurons is only 0.1-1% of DDC, and thus TH can be regarded as a rate-limiting factor for DA synthesis, and when TH activity is low, it may be ineffective or nonfunctional, and the effect of enhancing dopamine anabolism is very limited. Therefore, it is of great importance to develop a solid beverage capable of improving TH activity.
Disclosure of Invention
In order to improve activity of TH and promote anabolism of human dopamine, the application provides a solid beverage for promoting anabolism of human dopamine and a preparation method thereof.
In a first aspect, the present application provides a solid beverage for promoting dopamine anabolism in a human body, which adopts the following technical scheme:
a solid beverage for promoting dopamine anabolism of a human body, which comprises the following components in parts by weight:
200-300 parts of red date slow-release powder;
70-150 parts of protein peptide premix;
10-20 parts of egg yolk globulin powder;
5-50 parts of amino acid premix;
20-60 parts of sweetener;
50-100 parts of a wetting agent;
the preparation method of the red date slow-release powder comprises the following steps: adding red date powder, ginger powder and hydroxypropyl methylcellulose into chitosan hydrochloride solution, and stirring and mixing to obtain a mixture A; adding glyceraldehyde into the mixture A, stirring and mixing, filtering and discarding the filtrate, drying, crushing, and sieving with a 80-100 mesh sieve to obtain the red date slow-release powder.
By adopting the technical scheme, the red jujube powder is rich in a large amount of cyclic adenosine monophosphate (cAMP for short), and the phosphorylation of the cAMP can improve the activity of tyrosine hydroxylase (TH for short), so that the anabolism of dopamine (DA for short) is promoted. Gingerol in ginger powder has effects of inhibiting body inflammation, reducing "leptin resistance" caused by body inflammation, promoting body utilization of leptin and reducing leptin concentration in blood. The leptin concentration in blood is inversely related to the activity of TH, so that the activity of TH can be further improved by adding ginger powder, and the anabolism of DA can be promoted.
Meanwhile, chitosan is used as a carrier of the red date powder and the ginger powder, so that a slow release effect is achieved, the release time of beneficial substances in the red date powder and the ginger powder in a human body is prolonged, the duration of the effect of promoting TH activity caused by cAMP and gingerol in the ginger powder is prolonged, and the anabolism of DA is further promoted. In addition, the ginger powder is coated by the chitosan, so that the pungent taste in the solid beverage is reduced, and the flavor and the taste of the solid beverage are improved.
The solid beverage prepared by the application is subjected to animal serum dopamine content level experiments, and the DA concentration of the solid beverage is as low as 15.6 mug/g, which is higher than that of the solid beverage prepared by the red date slow-release powder which is not used, and 11.4 mug/g, which shows that the solid beverage added with the red date powder and the ginger powder can improve the DA concentration and promote the anabolism of DA; and in-vitro digestion simulation experiments are carried out, and the time for the cAMP and total phenol content of the solution to reach 90% of the initial content is minimally increased to 50min, so that the duration of the effect of promoting TH activity can be prolonged by adding the solid drink of chitosan.
Preferably, the weight ratio of the red date powder, the ginger powder and the chitosan hydrochloride solution is as follows: 1 (0.5-2) is (10-20); the concentration of the chitosan hydrochloride solution is 1-3wt%.
By adopting the technical scheme, when the weight ratio of the red date powder, the ginger powder and the chitosan hydrochloride solution is in the range, the compounding effect of the red date powder, the ginger powder and the chitosan hydrochloride solution is better, the solid beverage prepared by the application is subjected to animal serum dopamine content level experiments and in-vitro digestion simulation experiments, the DA concentration is improved to 18.4-19.3 mug/g, and the time for the cAMP and the total phenol content of the solution to reach 90% of the initial content is improved to 60min.
Preferably, the chitosan hydrochloride solution is prepared from modified chitosan, water, ethanol and hydrochloric acid; the preparation method of the modified chitosan comprises the following steps: adding chitosan into potassium chloride aqueous solution, heating, stirring and mixing to obtain a mixture B, adding genipin into the mixture B, stirring and mixing, standing, filtering and discarding filtrate, drying, pulverizing, and sieving with 200-500 mesh sieve to obtain modified chitosan.
Through adopting above-mentioned technical scheme, carry out animal serum dopamine content level experiment and external digestion simulation experiment with the solid beverage that this application made, its DA concentration promotes to 20.5 mu g/g from 19.3 mu g/g, and solution cAMP reaches the time of 90% of each initial content to 70min from 60min, promotes the anabolism effect of DA better after eating the solid beverage, and analysis its probably cause lies in:
in the chemical crosslinking process of chitosan and genipin, the potassium chloride can occupy part of the positions of the polymer, and then the potassium chloride is hydrolyzed and removed, so that a large number of micropores are formed on the surface of the polymer, the amount of chitosan loaded red date powder and ginger powder is increased, and a better slow release effect is achieved.
In addition, the potassium chloride is used as a common mineral water additive, and trace potassium chloride which is not removed by hydrolysis can supplement electrolyte of a human body after being taken.
Preferably, the weight ratio of the chitosan to the potassium chloride aqueous solution is 1:15-20.
By adopting the technical scheme, when the weight ratio of the chitosan to the potassium chloride aqueous solution is in the range, the compounding effect of the chitosan and the potassium chloride aqueous solution is better, and the anabolism effect of promoting DA after eating the solid beverage is better. The solid beverage prepared by the application is subjected to animal serum dopamine content level experiments and in-vitro digestion simulation experiments, the DA concentration is further improved to 21-21.5 mug/g, and the time for the cAMP and total phenol content of the solution to reach 90% of the initial content is further improved to 80min.
Preferably, the concentration of the potassium chloride aqueous solution is 0.1-0.5g/mL.
By adopting the technical scheme, when the concentration of the potassium chloride aqueous solution is in the range, the concentration of the potassium chloride aqueous solution is more suitable, and the chitosan surface is possibly promoted to generate more micropores, so that the amounts of the red date powder and the ginger powder loaded by the chitosan are more, and the anabolism effect of promoting DA is better after the solid beverage is eaten. The solid beverage prepared by the application is subjected to animal serum dopamine content level experiments and in-vitro digestion simulation experiments, the DA concentration is further improved to 21.9-22.3 mug/g, and the time for the cAMP and total phenol content of the solution to reach 90% of the initial content is further improved to 90min.
Preferably, maltodextrin is also added during the addition of glyceraldehyde to mixture a.
By adopting the technical scheme, the maltodextrin has good heat resistance, improves the stability of the red date powder and the ginger powder, reduces the viscosity of the red date powder and the ginger powder during drying, and reduces the occurrence of the condition that the red date slow-release powder adheres to the wall during the drying process.
Preferably, the protein peptide premix is one or more of medicinal peptide, bovine bone collagen peptide, tuna oligopeptide powder, coix seed oligopeptide powder, bovine heart peptide, bovine liver peptide, bovine spleen peptide, sheep lung peptide, bovine kidney peptide, sea cucumber peptide, ginseng peptide and oyster oligopeptide powder.
By adopting the technical scheme, during actual production, proper protein peptide additives can be selected according to the needs so as to meet different functional needs.
Preferably, the amino acid premix is a mixture of one or more of L-arginine hydrochloride, L-glutamic acid, L-lysine hydrochloride, L-aspartic acid, glycine, N-acetylneuraminic acid and L-glutamine.
By adopting the technical scheme, during actual production, proper amino acid additives can be selected according to the needs so as to meet different functional needs.
Preferably, the sweetener is one or more of sucralose, erythritol, aspartame, acesulfame potassium and steviol glycoside.
By adopting the technical scheme, the sweetness of the solid beverage is improved, the glucose concentration in blood is not influenced, the physical burden is reduced, and the solid beverage can be drunk for a long time, so that the solid beverage has a wide application prospect.
In a second aspect, the present application provides a method for preparing a solid beverage for promoting dopamine anabolism in a human body, which adopts the following technical scheme:
a method for preparing the solid beverage for promoting dopamine anabolism in human body according to claims 1-9, comprising the following steps: s1, mixing red date slow-release powder, a protein peptide premix, yolk globulin powder, an amino acid premix and a sweetener to obtain a mixture C;
s2, adding a wetting agent into the mixture C, and stirring and mixing to obtain a mixture D;
s3, granulating the mixture D, and drying at 10-20 ℃ to obtain the solid beverage for promoting the synthesis and metabolism of the dopamine in the human body.
By adopting the technical scheme, the components of the solid beverage are directly mixed, so that the method is direct and convenient, and the efficiency in industrial production can be improved.
In summary, the present application has the following beneficial effects:
1. according to the method, the TH activity is directly or indirectly improved by using the red date powder and the ginger powder, so that the anabolism of DA is promoted, and the slow release effect is achieved by using chitosan to load the red date powder and the ginger powder, so that the action time of improving the TH activity by cAMP and gingerol is prolonged, and the anabolism effect of DA is better;
2. in the application, potassium chloride is used for modifying chitosan, so that micropores are formed on the surface of the chitosan, the amount of chitosan loaded with red date powder and ginger powder is increased, and the anabolism effect of DA is further improved;
3. the method is convenient for processing and production, and the prepared solid beverage has higher portability.
Detailed Description
The present application is described in further detail below with reference to examples.
The raw materials used in the examples of the present application are commercially available except for the following specific descriptions:
red date powder: cAMP content of 371. Mu.g/g;
ginger powder: the total phenol content is 8.54mg/g, and gingerol mainly comprises 6-gingerol, 8-gingerol and 10-gingerol;
all raw material additive dosages in the embodiment of the application meet the use amount specified in GB 2760-2011 food additive use Standard.
Preparation example
Preparation example 1
A red date slow-release powder is prepared by the following steps: adding 1kg of red date powder, 0.4kg of ginger powder and 0.2kg of hydroxypropyl methyl cellulose into 8kg of chitosan hydrochloride solution, stirring and mixing, and reacting for 2 hours to obtain a mixture A; adding 0.5kg of glyceraldehyde into the mixture A, stirring and mixing, reacting for 3 hours, filtering and discarding the filtrate, drying, crushing and sieving with a 80-mesh sieve to obtain the red date slow-release powder;
the preparation method of the chitosan hydrochloride solution comprises the following steps: mixing chitosan, water, ethanol and hydrochloric acid with the concentration of 31wt percent uniformly according to the weight ratio of 0.8:60:45:0.2 (the concentration is 0.75wt percent), and obtaining chitosan hydrochloride solution, wherein the chitosan deacetylation degree is 80 percent and the water solubility is better;
wherein, spray drying is adopted for drying, the technological parameters are that the air inlet temperature is 160 ℃, and the air outlet temperature is 100 ℃.
PREPARATION EXAMPLES 2 to 4
The red date slow-release powder is different from the preparation example 1 in that the weight ratio of red date powder, ginger powder and chitosan hydrochloride solution is different, and is specifically shown in table 1.
Preparation examples 5 to 7
The red date slow-release powder is different from the preparation example 3 in that the concentration of chitosan hydrochloride solution is different, and is shown in table 1.
TABLE 1 parameters of the components in preparation examples 1 to 7
Preparation example 8
The red date slow-release powder is different from preparation example 6 in that an equivalent amount of modified chitosan is used for replacing chitosan, wherein the preparation method of the modified chitosan is as follows:
adding 1kg of chitosan into 25kg of potassium chloride aqueous solution with the concentration of 0.6g/mL, heating to 60 ℃, stirring and mixing, and reacting for 1h to obtain a mixture B; adding 0.6kg of genipin into the mixture B, stirring and mixing, reacting for 3 hours, standing for 1 hour, filtering and discarding filtrate, vacuum drying for 2 hours, crushing, and sieving with a 300-mesh sieve to obtain the modified chitosan.
Preparation examples 9 to 11
The red date slow-release powder is different from preparation example 8 in that the weight ratio of chitosan to potassium chloride aqueous solution is different, and is shown in table 2.
Preparation examples 12 to 14
The red date slow-release powder is different from preparation example 10 in the concentration of potassium chloride aqueous solution, and is shown in table 2.
TABLE 2 preparation examples 8-14 Components and weights (kg)
Preparation example 15
The red date slow-release powder is different from preparation example 13 in that maltodextrin with a weight ratio of 1:1 with chitosan is also added in the process of adding glyceraldehyde into the mixture A.
Examples
Example 1
The solid beverage for promoting the anabolism of the human body dopamine comprises the following components in parts by weight as shown in table 3, and is prepared by the following steps:
s1, mixing components except a wetting agent according to a table 3 to obtain a mixture C;
s2, adding 50kg of wetting agent into the mixture C, stirring and mixing, and reacting for 20min to obtain a mixture D, wherein the wetting agent is edible alcohol with the concentration of 70 wt%;
s3, granulating the mixture D, and drying at 20 ℃ for 5 hours to obtain the solid beverage for promoting the synthesis and metabolism of the dopamine in the human body;
wherein the red date slow-release powder is prepared from preparation example 1.
Examples 2 to 5
A solid beverage for promoting dopamine anabolism in human body is different from example 1 in that the amounts of each component used are different, specifically as shown in Table 3.
TABLE 3 weight (kg) of the components in examples 1-5
Wherein the protein peptide premix is medicinal peptide, bovine bone collagen peptide, tuna oligopeptide powder, coicis semen oligopeptide powder, bovine heart peptide, bovine liver peptide, bovine spleen peptide, sheep lung peptide, bovine kidney peptide, sea cucumber peptide, ginseng radix peptide, and oyster oligopeptide powder; it should be noted that, in other embodiments, different protein peptides may be added according to actual production requirements, so as to meet different functional requirements, and not affect the anabolism of DA.
The amino acid premix is L-arginine hydrochloride, L-glutamic acid, L-lysine hydrochloride, L-aspartic acid, glycine, N-acetylneuraminic acid, and L-glutamine; it should be noted that, in other embodiments, different amino acids may be selected and added according to actual production requirements, so as to meet different functional requirements, and not affect the anabolism of DA.
The sweetener is steviol glycoside with water content of 8%. In other embodiments, according to actual production requirements, a sweetener which is not absorbed by human body, such as sucralose, erythritol, aspartame, acesulfame potassium, etc., may be added, without affecting the anabolism of DA.
Examples 6 to 19
The solid beverage for promoting dopamine anabolism of human body is different from example 1 in that the use condition of the red date slow-release powder is different, and is specifically shown in table 4.
Comparative example
Comparative example 1
A solid beverage differs from example 1 in that an equivalent amount of soy protein powder is used instead of the red date slow release powder.
Comparative example 2
A solid beverage differs from example 1 in that the same amount of red date powder is used instead of the red date slow-release powder.
Comparative examples 3 to 4
A solid beverage was different from example 1 in the amounts of the components used, as shown in Table 5.
TABLE 5 Components of example 1, comparative examples 1-4 and weights (kg)
Performance detection
The solid beverages prepared in examples and comparative examples were subjected to the following test, and the test results are shown in table 6.
Experiment one, animal serum dopamine content level experiment: dissolving solid beverage in drinking water at concentration of 4wt%, and storing;
blank blood collection: collecting 0.5mL of venous blood of a mouse which is not fed for 12 hours, adding an anticoagulant, and preserving at a low temperature for later use;
and (5) collecting after eating: feeding the mice with the drinking water containing the solid beverage 1 hour after collecting blank blood, collecting 0.5mL of blood sample after eating for 30min, and centrifuging to obtain serum;
the concentration of dopamine in serum is detected by adopting a fluorescence spectrophotometry method, and the unit is mug/g.
Experiment two, in vitro digestion simulation experiment: dissolving solid beverage in artificial gastric juice at concentration of 0.25wt%, shaking at 37deg.C, taking out 1mL of solution every 10min, and detecting time when cAMP and total phenol content in the solution reach 90% (i.e. cAMP reaches 334 μg/g and total phenol reaches 7.69 mg/g) or more;
preparation of artificial gastric juice: diluting 23.4mL of concentrated hydrochloric acid to 100mL, taking 1.64mL again, dissolving 100mg of pepsin to 4g/L, taking out 30mL, adjusting pH to 2, adding 1g of sodium chloride for dissolution, and obtaining artificial gastric juice, and preserving at 4 ℃ for later use;
the taken solution is detected by a high performance liquid chromatograph under the following detection conditions: the column temperature is 35 ℃, the ultraviolet wavelength is 280nm, the flow rate of the mobile phase is 1mL/min, the sample injection amount is 10 mu L, and the mobile phase is acetonitrile and water.
TABLE 6 Performance test results for examples 1-19, comparative examples 1-4
The properties of the solid beverages prepared in the present application were analyzed in the following manner in combination with the corresponding data in examples 1 to 19, comparative examples 1 to 4 and Table 6.
As can be seen from table 6, in comparative example 1, the concentration of dopamine (abbreviated as DA) in the serum of mice was 11.4 μg/g, and the level of dopamine was in a steady state by drinking the solid beverage prepared by replacing the red date slow-release powder with an equal amount of soybean protein powder; in comparative example 2, the DA concentration in the serum of mice was 13.1. Mu.g/g by drinking an equal amount of red date powder instead of the red date slow-release powder, and the time taken for the cAMP and total phenol contents of the solutions to reach 90% of the respective initial contents was measured to be 30min.
In example 1, however, the concentration of DA in serum after drinking of mice was 15.6. Mu.g/g, and the time taken for the cAMP and total phenol content of the solution to reach 90% of the respective initial contents was measured to be 50min, because of using the solid drink prepared from the red date slow-release powder prepared in preparation example 1.
Compared with comparative example 1, the concentration of DA in example 1 is greatly improved, which indicates that the solid beverage prepared by the application is probably due to the addition of the red date powder and the ginger powder, and the anabolism of DA is promoted; compared with comparative example 2, the time for the solution cAMP and total phenol content in example 1 to reach 90% of the initial content respectively is prolonged from 30min to 50min, and the DA concentration is also improved, which indicates that the red date powder and the ginger powder are loaded and have a slow release effect probably due to the addition of chitosan, and the duration of the effect of promoting TH activity in human bodies of cAMP in the red date powder and gingerol in the ginger powder is prolonged, so that the anabolism of DA is further promoted.
Examples 2 to 5 and comparative examples 3 to 4 differ from example 1 in the amounts of the respective components used. The DA concentration in examples 1-5 was 15.6-16.9. Mu.g/g, and the time taken for the cAMP and total phenol content of the solutions to reach 90% of the respective initial contents was 50min, whereas the DA concentration in comparative examples 3-4 was 14.9-15.2. Mu.g/g, and the time taken for the cAMP and total phenol content of the solutions to reach 90% of the respective initial contents was only 40min, which were lower than those in examples 1-5, indicating that the effect of promoting DA anabolism was better when the contents of the components in the solid beverage were in the range of examples 1-5.
Examples 6-8 differ from example 3 in that the weight ratio of red date powder, ginger extract and chitosan hydrochloride solution is different in the preparation process of red date slow-release powder, and the DA concentration in examples 6-8 is higher than that in example 3. And the DA concentration was highest at 17.9 μg/g when the weight ratio of red date powder, ginger extract and chitosan hydrochloride solution was 1:1:15 (example 7).
Examples 9-11 are different from example 7 in that the chitosan hydrochloride concentration is different in the preparation process of the red date slow-release powder, and the time for the solution cAMP and total phenol content in examples 9-11 to reach 90% of the initial content respectively reaches 60min, which is higher than 50min in example 6, which shows that the effect of prolonging and improving TH activity is better when the chitosan hydrochloride concentration is in the range of 1-3wt%.
Example 12 is different from example 10 in that in the preparation process of the red date slow-release powder, the red date slow-release powder is prepared by using modified chitosan instead of chitosan in preparation example 8, so that the DA concentration in serum reaches 20.5 mug/g after a mouse drinks a solid beverage, the time for the cAMP content and the total phenol content of the solution to reach 90% of the initial content respectively reaches 70min, and compared with example 10, the analysis is possible because the potassium chloride is used to cause more micropores on the surface of the chitosan, the amount of the chitosan loaded red date powder and the ginger powder is improved, and the effect of improving TH activity is better.
Examples 13-15 differ from example 12 in that the weight ratio of chitosan to aqueous potassium chloride solution is different during the preparation of the red date slow-release powder. The DA concentration in examples 13-15 reached 21.0-21.5. Mu.g/g, the cAMP and total phenol content in the solution reached 90% of the respective initial levels for 80min, and the data were all superior to example 10, indicating that it was optimal when the weight ratio of chitosan to aqueous potassium chloride solution was 1:18 (example 12).
Examples 16-18 differ from example 14 in the concentration of the aqueous potassium chloride solution during the preparation of the slow-release powder of red dates. The time for the DA concentration, solution cAMP, and total phenol content to reach 90% of the respective initial contents in examples 14 to 16 was further increased compared to example 14, especially from 80min to 90min, indicating that the solid beverage prolonged the TH activity longer when the concentration of the aqueous potassium chloride solution was 0.1 to 0.5g/mL.
Example 19 differs from example 17 in that maltodextrin was also added during the process of adding glyceraldehyde to mixture a during the preparation of the red date slow release powder. The occurrence of wall sticking of the red date powder and the ginger powder in the drying process is reduced, and the sufficient effective components of the red date powder and the ginger powder in the solid beverage are ensured to the greatest extent.
The present embodiment is only illustrative of the present application and is not intended to be limiting, and modifications may be made to the embodiment by those skilled in the art without creative contribution as needed after reading the present specification, but are protected by patent laws within the scope of the claims of the present application.
Claims (8)
1. The solid beverage for promoting the anabolism of the dopamine in the human body is characterized by comprising the following raw materials in parts by weight:
200-300 parts of red date slow-release powder;
70-150 parts of protein peptide premix;
10-20 parts of egg yolk globulin powder;
5-50 parts of amino acid premix;
20-60 parts of sweetener;
50-100 parts of a wetting agent;
the preparation method of the red date slow-release powder comprises the following steps: adding red date powder, ginger powder and hydroxypropyl methylcellulose into chitosan hydrochloride solution, and stirring and mixing to obtain a mixture A; adding glyceraldehyde into the mixture A, stirring and mixing, filtering and discarding the filtrate, drying, crushing, and sieving with a 80-100 mesh sieve to obtain the red date slow-release powder;
the weight ratio of the red date powder to the ginger powder to the chitosan hydrochloride solution is 1 (0.5-2): 10-20; the concentration of the chitosan hydrochloride solution is 1-3wt%;
the preparation raw materials of the chitosan hydrochloride solution comprise modified chitosan, water, ethanol and hydrochloric acid;
the preparation method of the modified chitosan comprises the following steps: adding chitosan into potassium chloride aqueous solution, heating, stirring and mixing to obtain a mixture B, adding genipin into the mixture B, stirring and mixing, standing, filtering and discarding filtrate, drying, pulverizing, and sieving with 200-500 mesh sieve to obtain modified chitosan.
2. A solid beverage for promoting dopamine anabolism in a human as recited in claim 1, wherein: the weight ratio of the chitosan to the potassium chloride aqueous solution is 1:15-20.
3. A solid beverage for promoting dopamine anabolism in a human as recited in claim 1, wherein: the concentration of the potassium chloride aqueous solution is 0.1-0.5g/mL.
4. A solid beverage for promoting dopamine anabolism in a human as recited in claim 1, wherein: during the addition of glyceraldehyde to mixture a, maltodextrin was also added.
5. A solid beverage for promoting dopamine anabolism in a human as recited in claim 1, wherein: the protein peptide premix is one or more of bovine bone collagen peptide, tuna oligopeptide powder, coix seed oligopeptide powder, bovine heart peptide, bovine liver peptide, bovine spleen peptide, sheep lung peptide, bovine kidney peptide, sea cucumber peptide, ginseng peptide and oyster oligopeptide powder.
6. A solid beverage for promoting dopamine anabolism in a human as recited in claim 1, wherein: the amino acid premix is a mixture composed of one or more of L-arginine hydrochloride, L-glutamic acid, L-lysine hydrochloride, L-aspartic acid, glycine, N-acetylneuraminic acid and L-glutamine.
7. A solid beverage for promoting dopamine anabolism in a human as recited in claim 1, wherein: the sweetener is one or more of sucralose, erythritol, aspartame, acesulfame potassium and steviol glycoside.
8. A method for preparing a solid beverage for promoting dopamine anabolism in a human body according to any one of claims 1 to 7, comprising the steps of:
s1, mixing red date slow-release powder, a protein peptide premix, yolk globulin powder, an amino acid premix and a sweetener to obtain a mixture C;
s2, adding a wetting agent into the mixture C, and stirring and mixing to obtain a mixture D;
s3, granulating the mixture D, and drying at 10-20 ℃ to obtain the solid beverage for promoting the synthesis and metabolism of the dopamine in the human body.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202210968100.8A CN115299543B (en) | 2022-08-12 | 2022-08-12 | Solid beverage for promoting human dopamine anabolism and preparation method thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202210968100.8A CN115299543B (en) | 2022-08-12 | 2022-08-12 | Solid beverage for promoting human dopamine anabolism and preparation method thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
CN115299543A CN115299543A (en) | 2022-11-08 |
CN115299543B true CN115299543B (en) | 2023-07-21 |
Family
ID=83862418
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202210968100.8A Active CN115299543B (en) | 2022-08-12 | 2022-08-12 | Solid beverage for promoting human dopamine anabolism and preparation method thereof |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN115299543B (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN115624614B (en) * | 2022-12-08 | 2023-04-07 | 北京第一生物科技开发有限公司 | Application of bovine spleen peptide powder in preventing or treating depression |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5283743B2 (en) * | 2011-10-07 | 2013-09-04 | 富士フイルム株式会社 | Beverage composition |
CN110916181A (en) * | 2019-12-12 | 2020-03-27 | 林健 | Natural compound mood regulator, solid beverage mixture, beverage and preparation method |
CN114698764A (en) * | 2021-12-22 | 2022-07-05 | 天津泰创生物科技有限公司 | Sodium hyaluronate elastin peptide solid beverage and preparation method thereof |
-
2022
- 2022-08-12 CN CN202210968100.8A patent/CN115299543B/en active Active
Also Published As
Publication number | Publication date |
---|---|
CN115299543A (en) | 2022-11-08 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US10532079B2 (en) | Extracts and beverages containing 2,5-piperazinedione, 3,6-bis(phenylmethyl)-, (3S,6S)- | |
CA2649842A1 (en) | Composition containing peptide as active ingredient | |
CN115299543B (en) | Solid beverage for promoting human dopamine anabolism and preparation method thereof | |
CN1771838A (en) | Liquid quelite | |
BRPI0711610B1 (en) | method for producing a guava leaf extract powder and food or beverage containing said powder | |
CN104664039A (en) | Saury Maillard peptide with uric acid reducing activity as well as preparation method and application thereof | |
JP2008510494A (en) | Compositions and methods for deactivation of catabolic processes and protein synthesis in skeletal muscle | |
JP2000157226A (en) | Enzymolysis product of laver and its use | |
WO2006118090A1 (en) | Water-containing food | |
US10631559B2 (en) | Acidic extracts and beverages containing 2,5-piperazinedione,3,6-bis(phenylmethyl)-(3S,6S)- | |
CN109007848B (en) | Compound oligopeptide capable of improving sexual function and resisting fatigue, oral preparation of compound oligopeptide and preparation method of oral preparation | |
CN107847545B (en) | Composition containing cyclic dipeptide and sweetener | |
US20060275346A1 (en) | Liquid seasoning | |
KR101347912B1 (en) | Method for prepairing sauce using enzyme-treated hydrolysates of abalone and laver | |
CN103006643B (en) | Compound injection containing 18 amino acids and preparation method thereof | |
CN104349684A (en) | Aqueous liquid beverage | |
JPH11151072A (en) | Soybean food material containing enriched gamma-aminobutyric acid | |
JP5872725B1 (en) | Dipeptidyl peptidase IV inhibitory composition derived from bonito | |
CN111418850A (en) | Composition for dispelling effects of alcohol and protecting liver and preparation method thereof | |
CN110623244A (en) | Preparation method of salty peptide | |
CN112868957A (en) | Compound hydrolyzed peptide beverage for enhancing immunity and resisting fatigue | |
CN107259559B (en) | Rapeseed polypeptide and schisandra chinensis aqueous extract and method for synergistically improving sleep | |
JP5312780B2 (en) | Food / drink and pharmaceutical composition for reducing blood ammonia concentration | |
JP2007045751A (en) | Liver function-activating agent | |
TW201904444A (en) | A manufacture method of a seasoning from brown algae extract and a seasoning manufactured by the thereof manufacture method |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant |