CN115297875A - 治疗炎症性肠病的方法ii - Google Patents

治疗炎症性肠病的方法ii Download PDF

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Publication number
CN115297875A
CN115297875A CN202180020526.4A CN202180020526A CN115297875A CN 115297875 A CN115297875 A CN 115297875A CN 202180020526 A CN202180020526 A CN 202180020526A CN 115297875 A CN115297875 A CN 115297875A
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China
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subject
cells
composition
administered
disease
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Pending
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CN202180020526.4A
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English (en)
Chinese (zh)
Inventor
S·伊茨库
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Mesoblast International SARL
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Mesoblast International SARL
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Priority claimed from AU2020900743A external-priority patent/AU2020900743A0/en
Application filed by Mesoblast International SARL filed Critical Mesoblast International SARL
Publication of CN115297875A publication Critical patent/CN115297875A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0031—Rectum, anus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Virology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
CN202180020526.4A 2020-03-11 2021-03-11 治疗炎症性肠病的方法ii Pending CN115297875A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2020900743A AU2020900743A0 (en) 2020-03-11 Method for treating inflammatory bowel disease II
AU2020900743 2020-03-11
PCT/EP2021/056193 WO2021180851A1 (en) 2020-03-11 2021-03-11 Method for treating inflammatory bowel disease ii

Publications (1)

Publication Number Publication Date
CN115297875A true CN115297875A (zh) 2022-11-04

Family

ID=74884938

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202180020526.4A Pending CN115297875A (zh) 2020-03-11 2021-03-11 治疗炎症性肠病的方法ii

Country Status (9)

Country Link
US (1) US20230104108A1 (enExample)
EP (1) EP4117623A1 (enExample)
JP (1) JP2023517641A (enExample)
KR (1) KR20220152240A (enExample)
CN (1) CN115297875A (enExample)
AU (1) AU2021235055A1 (enExample)
BR (1) BR112022018022A2 (enExample)
CA (1) CA3170918A1 (enExample)
WO (1) WO2021180851A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070258963A1 (en) 2006-01-13 2007-11-08 Osiris Therapeutics, Inc. Mesenchymal stem cells expressing TNF-alpha receptors
US20120087868A1 (en) 2010-10-08 2012-04-12 Gabriele Todd Nanoparticle-loaded cells
SG11202004680UA (en) 2017-11-22 2020-06-29 Mesoblast Int Sarl Cellular compositions and methods of treatment i
WO2021180850A1 (en) * 2020-03-11 2021-09-16 Mesoblast International Sàrl Method for treating inflammatory bowel disease i

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104873542A (zh) * 2015-05-21 2015-09-02 北京青藤谷禧干细胞科技研究院有限公司 一种脐带间充质干细胞注射液及其制备方法和应用
WO2018002930A1 (en) * 2016-06-30 2018-01-04 Stem Cell Medicine Ltd. Treatment of inflammatory bowel disease with long acting glatiramer and adipose-derived stem cells
WO2018182612A1 (en) * 2017-03-30 2018-10-04 Progenity Inc. Methods and ingestible devices for the regio-specific release of stem cells at the site of gastrointestinal tract disease
CN108883135A (zh) * 2016-03-14 2018-11-23 泰根尼克斯独资有限公司 用于治疗克罗恩病的难治性、复杂性肛周瘘的脂肪组织来源的基质干细胞

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5486359A (en) 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
US6251295B1 (en) 1998-01-08 2001-06-26 Nexell Therapeutics Inc. Method for recirculation washing of blood cells
US20070026377A1 (en) * 2000-02-10 2007-02-01 The Regents Of The University Of California Methods for preserving nucleated mammalian cells
US8465733B2 (en) * 2007-11-02 2013-06-18 Jcr Pharmaceuticals Co., Ltd. Pharmaceutical composition containing human mesenchymal stem cell
EP3419635B1 (en) * 2016-02-22 2022-01-05 Centauri Biotech, S.L. Pharmaceutical or veterinary cell compositions comprising mesenchymal stromal cells (mscs) and dimethyl sulfoxide (dmso)
WO2021180850A1 (en) * 2020-03-11 2021-09-16 Mesoblast International Sàrl Method for treating inflammatory bowel disease i

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104873542A (zh) * 2015-05-21 2015-09-02 北京青藤谷禧干细胞科技研究院有限公司 一种脐带间充质干细胞注射液及其制备方法和应用
CN108883135A (zh) * 2016-03-14 2018-11-23 泰根尼克斯独资有限公司 用于治疗克罗恩病的难治性、复杂性肛周瘘的脂肪组织来源的基质干细胞
WO2018002930A1 (en) * 2016-06-30 2018-01-04 Stem Cell Medicine Ltd. Treatment of inflammatory bowel disease with long acting glatiramer and adipose-derived stem cells
WO2018182612A1 (en) * 2017-03-30 2018-10-04 Progenity Inc. Methods and ingestible devices for the regio-specific release of stem cells at the site of gastrointestinal tract disease

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
FERNANDO DE LA PORTILLA等: "Local Mesenchymal Stem Cell Therapy in Experimentally Induced Colitis in the Rat", INTERNATIONAL JOURNAL OF STEM CELLS, vol. 11, no. 1, 30 April 2018 (2018-04-30), pages 1 - 9 *
JULIÁN PANÉS等: "Long-term Efficacy and Safety of Stem Cell Therapy (Cx601) for Complex Perianal Fistulas in Patients With Crohn’s Disease", GASTROENTEROLOGY, vol. 154, 30 April 2018 (2018-04-30), pages 1334 *
顾嫣等: "骨髓干细胞治疗炎症性肠病的研究进展", 胃肠病学和肝病学杂志, no. 10, 20 October 2009 (2009-10-20), pages 889 - 892 *
顾雪香等: "间充质干细胞在重度炎症性肠病治疗中的研究进展", 胃肠病学, no. 12, 25 December 2017 (2017-12-25), pages 54 - 57 *

Also Published As

Publication number Publication date
AU2021235055A1 (en) 2022-09-29
US20230104108A1 (en) 2023-04-06
EP4117623A1 (en) 2023-01-18
WO2021180851A1 (en) 2021-09-16
JP2023517641A (ja) 2023-04-26
KR20220152240A (ko) 2022-11-15
BR112022018022A2 (pt) 2022-10-18
CA3170918A1 (en) 2021-09-16

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