CN115297825A - 组合物 - Google Patents
组合物 Download PDFInfo
- Publication number
- CN115297825A CN115297825A CN202180021738.4A CN202180021738A CN115297825A CN 115297825 A CN115297825 A CN 115297825A CN 202180021738 A CN202180021738 A CN 202180021738A CN 115297825 A CN115297825 A CN 115297825A
- Authority
- CN
- China
- Prior art keywords
- gum
- carrageenan
- composition
- composition according
- enzyme
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 98
- 229910044991 metal oxide Inorganic materials 0.000 title description 4
- 150000004706 metal oxides Chemical class 0.000 title description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 39
- 102000004190 Enzymes Human genes 0.000 claims abstract description 28
- 108090000790 Enzymes Proteins 0.000 claims abstract description 28
- 239000000679 carrageenan Substances 0.000 claims abstract description 25
- 229920001525 carrageenan Polymers 0.000 claims abstract description 25
- 229940113118 carrageenan Drugs 0.000 claims abstract description 25
- 235000010418 carrageenan Nutrition 0.000 claims abstract description 23
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims abstract description 23
- 239000000377 silicon dioxide Substances 0.000 claims abstract description 19
- 229920001206 natural gum Polymers 0.000 claims abstract description 14
- 229920001285 xanthan gum Polymers 0.000 claims abstract description 14
- 235000010493 xanthan gum Nutrition 0.000 claims abstract description 14
- 239000000230 xanthan gum Substances 0.000 claims abstract description 14
- 229940082509 xanthan gum Drugs 0.000 claims abstract description 14
- 244000215068 Acacia senegal Species 0.000 claims abstract description 6
- 241000416162 Astragalus gummifer Species 0.000 claims abstract description 6
- 229920002907 Guar gum Polymers 0.000 claims abstract description 6
- 229920000084 Gum arabic Polymers 0.000 claims abstract description 6
- 229920000569 Gum karaya Polymers 0.000 claims abstract description 6
- 241000934878 Sterculia Species 0.000 claims abstract description 6
- 229920001615 Tragacanth Polymers 0.000 claims abstract description 6
- 235000010489 acacia gum Nutrition 0.000 claims abstract description 6
- 239000000205 acacia gum Substances 0.000 claims abstract description 6
- 235000010417 guar gum Nutrition 0.000 claims abstract description 6
- 239000000665 guar gum Substances 0.000 claims abstract description 6
- 229960002154 guar gum Drugs 0.000 claims abstract description 6
- 235000010494 karaya gum Nutrition 0.000 claims abstract description 6
- 239000000231 karaya gum Substances 0.000 claims abstract description 6
- 229940039371 karaya gum Drugs 0.000 claims abstract description 6
- 229940088598 enzyme Drugs 0.000 claims description 27
- 108010015776 Glucose oxidase Proteins 0.000 claims description 11
- 235000019420 glucose oxidase Nutrition 0.000 claims description 10
- 239000004366 Glucose oxidase Substances 0.000 claims description 9
- 230000000694 effects Effects 0.000 claims description 9
- 229940116332 glucose oxidase Drugs 0.000 claims description 9
- 239000000606 toothpaste Substances 0.000 claims description 9
- 239000004094 surface-active agent Substances 0.000 claims description 8
- 229940034610 toothpaste Drugs 0.000 claims description 7
- 239000002202 Polyethylene glycol Substances 0.000 claims description 6
- 229920001223 polyethylene glycol Polymers 0.000 claims description 6
- 108090000854 Oxidoreductases Proteins 0.000 claims description 5
- 102000004316 Oxidoreductases Human genes 0.000 claims description 5
- 230000008719 thickening Effects 0.000 claims description 5
- 108010073178 Glucan 1,4-alpha-Glucosidase Proteins 0.000 claims description 4
- 108010031186 Glycoside Hydrolases Proteins 0.000 claims description 4
- 102000005744 Glycoside Hydrolases Human genes 0.000 claims description 4
- 108050006227 Haem peroxidases Proteins 0.000 claims description 4
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 claims description 4
- 150000002191 fatty alcohols Chemical class 0.000 claims description 4
- 108010023244 Lactoperoxidase Proteins 0.000 claims description 3
- 102000045576 Lactoperoxidases Human genes 0.000 claims description 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 3
- 229940057428 lactoperoxidase Drugs 0.000 claims description 3
- 102000013142 Amylases Human genes 0.000 claims description 2
- 108010065511 Amylases Proteins 0.000 claims description 2
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical group C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims description 2
- ZNOZWUKQPJXOIG-XSBHQQIPSA-L [(2r,3s,4r,5r,6s)-6-[[(1r,3s,4r,5r,8s)-3,4-dihydroxy-2,6-dioxabicyclo[3.2.1]octan-8-yl]oxy]-4-[[(1r,3r,4r,5r,8s)-8-[(2s,3r,4r,5r,6r)-3,4-dihydroxy-6-(hydroxymethyl)-5-sulfonatooxyoxan-2-yl]oxy-4-hydroxy-2,6-dioxabicyclo[3.2.1]octan-3-yl]oxy]-5-hydroxy-2-( Chemical compound O[C@@H]1[C@@H](O)[C@@H](OS([O-])(=O)=O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H]2OC[C@H]1O[C@H](O[C@H]1[C@H]([C@@H](CO)O[C@@H](O[C@@H]3[C@@H]4OC[C@H]3O[C@H](O)[C@@H]4O)[C@@H]1O)OS([O-])(=O)=O)[C@@H]2O ZNOZWUKQPJXOIG-XSBHQQIPSA-L 0.000 claims description 2
- 235000019418 amylase Nutrition 0.000 claims description 2
- 229940025131 amylases Drugs 0.000 claims 1
- 239000000551 dentifrice Substances 0.000 abstract description 7
- 229920000642 polymer Polymers 0.000 description 12
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 11
- 239000000126 substance Substances 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- 239000000499 gel Substances 0.000 description 6
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 6
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 5
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 239000000600 sorbitol Substances 0.000 description 5
- 229960002920 sorbitol Drugs 0.000 description 5
- 235000010356 sorbitol Nutrition 0.000 description 5
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 4
- -1 amine fluorides Chemical class 0.000 description 4
- 230000008859 change Effects 0.000 description 4
- 235000011187 glycerol Nutrition 0.000 description 4
- 229960005150 glycerol Drugs 0.000 description 4
- 239000001257 hydrogen Substances 0.000 description 4
- 229910052739 hydrogen Inorganic materials 0.000 description 4
- 230000003993 interaction Effects 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 239000006072 paste Substances 0.000 description 4
- 229920005862 polyol Polymers 0.000 description 4
- 150000003077 polyols Chemical class 0.000 description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- 230000002776 aggregation Effects 0.000 description 3
- 238000004220 aggregation Methods 0.000 description 3
- 230000001965 increasing effect Effects 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 239000011775 sodium fluoride Substances 0.000 description 3
- 235000013024 sodium fluoride Nutrition 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
- INVGWHRKADIJHF-UHFFFAOYSA-N Sanguinarin Chemical compound C1=C2OCOC2=CC2=C3[N+](C)=CC4=C(OCO5)C5=CC=C4C3=CC=C21 INVGWHRKADIJHF-UHFFFAOYSA-N 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 2
- WHMDKBIGKVEYHS-IYEMJOQQSA-L Zinc gluconate Chemical compound [Zn+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O WHMDKBIGKVEYHS-IYEMJOQQSA-L 0.000 description 2
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 2
- 239000003082 abrasive agent Substances 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 239000004599 antimicrobial Substances 0.000 description 2
- 230000001680 brushing effect Effects 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 229960003563 calcium carbonate Drugs 0.000 description 2
- 229910000019 calcium carbonate Inorganic materials 0.000 description 2
- 235000010216 calcium carbonate Nutrition 0.000 description 2
- 239000001506 calcium phosphate Substances 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000001351 cycling effect Effects 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 239000003349 gelling agent Substances 0.000 description 2
- 239000003906 humectant Substances 0.000 description 2
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 2
- 210000000214 mouth Anatomy 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 235000018102 proteins Nutrition 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 229960000414 sodium fluoride Drugs 0.000 description 2
- 229960004711 sodium monofluorophosphate Drugs 0.000 description 2
- UGTZMIPZNRIWHX-UHFFFAOYSA-K sodium trimetaphosphate Chemical compound [Na+].[Na+].[Na+].[O-]P1(=O)OP([O-])(=O)OP([O-])(=O)O1 UGTZMIPZNRIWHX-UHFFFAOYSA-K 0.000 description 2
- ANOBYBYXJXCGBS-UHFFFAOYSA-L stannous fluoride Chemical compound F[Sn]F ANOBYBYXJXCGBS-UHFFFAOYSA-L 0.000 description 2
- 229960002799 stannous fluoride Drugs 0.000 description 2
- 229940080728 steareth-30 Drugs 0.000 description 2
- 150000005846 sugar alcohols Polymers 0.000 description 2
- 239000002562 thickening agent Substances 0.000 description 2
- 235000010447 xylitol Nutrition 0.000 description 2
- 239000000811 xylitol Substances 0.000 description 2
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 2
- 229960002675 xylitol Drugs 0.000 description 2
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical group [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 description 2
- BHHYHSUAOQUXJK-UHFFFAOYSA-L zinc fluoride Chemical compound F[Zn]F BHHYHSUAOQUXJK-UHFFFAOYSA-L 0.000 description 2
- 239000011670 zinc gluconate Substances 0.000 description 2
- 235000011478 zinc gluconate Nutrition 0.000 description 2
- 229960000306 zinc gluconate Drugs 0.000 description 2
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 description 1
- PKMTWMDBJHRDBM-ODZAUARKSA-N (z)-but-2-enedioic acid;zinc Chemical compound [Zn].OC(=O)\C=C/C(O)=O PKMTWMDBJHRDBM-ODZAUARKSA-N 0.000 description 1
- DTOUUUZOYKYHEP-UHFFFAOYSA-N 1,3-bis(2-ethylhexyl)-5-methyl-1,3-diazinan-5-amine Chemical compound CCCCC(CC)CN1CN(CC(CC)CCCC)CC(C)(N)C1 DTOUUUZOYKYHEP-UHFFFAOYSA-N 0.000 description 1
- TYBHZVUFOINFDV-UHFFFAOYSA-N 2-bromo-6-[(3-bromo-5-chloro-2-hydroxyphenyl)methyl]-4-chlorophenol Chemical compound OC1=C(Br)C=C(Cl)C=C1CC1=CC(Cl)=CC(Br)=C1O TYBHZVUFOINFDV-UHFFFAOYSA-N 0.000 description 1
- GHCZTIFQWKKGSB-UHFFFAOYSA-N 2-hydroxypropane-1,2,3-tricarboxylic acid;phosphoric acid Chemical compound OP(O)(O)=O.OC(=O)CC(O)(C(O)=O)CC(O)=O GHCZTIFQWKKGSB-UHFFFAOYSA-N 0.000 description 1
- DDFHBQSCUXNBSA-UHFFFAOYSA-N 5-(5-carboxythiophen-2-yl)thiophene-2-carboxylic acid Chemical compound S1C(C(=O)O)=CC=C1C1=CC=C(C(O)=O)S1 DDFHBQSCUXNBSA-UHFFFAOYSA-N 0.000 description 1
- 239000004382 Amylase Substances 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
- 108010062877 Bacteriocins Proteins 0.000 description 1
- 229940123208 Biguanide Drugs 0.000 description 1
- 239000001736 Calcium glycerylphosphate Substances 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- 235000019739 Dicalciumphosphate Nutrition 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- FCEXWTOTHXCQCQ-UHFFFAOYSA-N Ethoxydihydrosanguinarine Natural products C12=CC=C3OCOC3=C2C(OCC)N(C)C(C2=C3)=C1C=CC2=CC1=C3OCO1 FCEXWTOTHXCQCQ-UHFFFAOYSA-N 0.000 description 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 1
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 1
- 108010063045 Lactoferrin Proteins 0.000 description 1
- 102000010445 Lactoferrin Human genes 0.000 description 1
- 244000246386 Mentha pulegium Species 0.000 description 1
- 235000016257 Mentha pulegium Nutrition 0.000 description 1
- 235000004357 Mentha x piperita Nutrition 0.000 description 1
- 102000016943 Muramidase Human genes 0.000 description 1
- 108010014251 Muramidase Proteins 0.000 description 1
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 1
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical class OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 description 1
- CANRESZKMUPMAE-UHFFFAOYSA-L Zinc lactate Chemical compound [Zn+2].CC(O)C([O-])=O.CC(O)C([O-])=O CANRESZKMUPMAE-UHFFFAOYSA-L 0.000 description 1
- ZOIORXHNWRGPMV-UHFFFAOYSA-N acetic acid;zinc Chemical compound [Zn].CC(O)=O.CC(O)=O ZOIORXHNWRGPMV-UHFFFAOYSA-N 0.000 description 1
- 229960001138 acetylsalicylic acid Drugs 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 239000004964 aerogel Substances 0.000 description 1
- LFVVNPBBFUSSHL-UHFFFAOYSA-N alexidine Chemical compound CCCCC(CC)CNC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NCC(CC)CCCC LFVVNPBBFUSSHL-UHFFFAOYSA-N 0.000 description 1
- 229950010221 alexidine Drugs 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 150000001340 alkali metals Chemical class 0.000 description 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- SNAAJJQQZSMGQD-UHFFFAOYSA-N aluminum magnesium Chemical compound [Mg].[Al] SNAAJJQQZSMGQD-UHFFFAOYSA-N 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000002280 amphoteric surfactant Substances 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 230000002272 anti-calculus Effects 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 229940027983 antiseptic and disinfectant quaternary ammonium compound Drugs 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- UILNZNXXNSBJFL-UHFFFAOYSA-N azanium;cobalt;fluoride Chemical compound [NH4+].[F-].[Co] UILNZNXXNSBJFL-UHFFFAOYSA-N 0.000 description 1
- XVRKEHYQBKGNBA-UHFFFAOYSA-N azanium;zinc;fluoride Chemical compound [NH4+].[F-].[Zn] XVRKEHYQBKGNBA-UHFFFAOYSA-N 0.000 description 1
- 150000004283 biguanides Chemical class 0.000 description 1
- IISBACLAFKSPIT-UHFFFAOYSA-N bisphenol A Chemical class C=1C=C(O)C=CC=1C(C)(C)C1=CC=C(O)C=C1 IISBACLAFKSPIT-UHFFFAOYSA-N 0.000 description 1
- 239000007844 bleaching agent Substances 0.000 description 1
- 239000006172 buffering agent Substances 0.000 description 1
- WUKWITHWXAAZEY-UHFFFAOYSA-L calcium difluoride Chemical compound [F-].[F-].[Ca+2] WUKWITHWXAAZEY-UHFFFAOYSA-L 0.000 description 1
- 229910001634 calcium fluoride Inorganic materials 0.000 description 1
- UHHRFSOMMCWGSO-UHFFFAOYSA-L calcium glycerophosphate Chemical compound [Ca+2].OCC(CO)OP([O-])([O-])=O UHHRFSOMMCWGSO-UHFFFAOYSA-L 0.000 description 1
- 229940095618 calcium glycerophosphate Drugs 0.000 description 1
- 235000019299 calcium glycerylphosphate Nutrition 0.000 description 1
- MKJXYGKVIBWPFZ-UHFFFAOYSA-L calcium lactate Chemical compound [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 description 1
- 239000001527 calcium lactate Substances 0.000 description 1
- 235000011086 calcium lactate Nutrition 0.000 description 1
- 229960002401 calcium lactate Drugs 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 235000013877 carbamide Nutrition 0.000 description 1
- 239000004075 cariostatic agent Substances 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
- 235000005487 catechin Nutrition 0.000 description 1
- ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 229960001927 cetylpyridinium chloride Drugs 0.000 description 1
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 229960003260 chlorhexidine Drugs 0.000 description 1
- 229950001002 cianidanol Drugs 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000012459 cleaning agent Substances 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 235000021277 colostrum Nutrition 0.000 description 1
- 210000003022 colostrum Anatomy 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000003975 dentin desensitizing agent Substances 0.000 description 1
- 230000000368 destabilizing effect Effects 0.000 description 1
- NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 description 1
- 229910000390 dicalcium phosphate Inorganic materials 0.000 description 1
- 229940038472 dicalcium phosphate Drugs 0.000 description 1
- 235000011180 diphosphates Nutrition 0.000 description 1
- IRXRGVFLQOSHOH-UHFFFAOYSA-L dipotassium;oxalate Chemical compound [K+].[K+].[O-]C(=O)C([O-])=O IRXRGVFLQOSHOH-UHFFFAOYSA-L 0.000 description 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
- 229910000397 disodium phosphate Inorganic materials 0.000 description 1
- 235000019800 disodium phosphate Nutrition 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 230000009881 electrostatic interaction Effects 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 229940091249 fluoride supplement Drugs 0.000 description 1
- 229960002390 flurbiprofen Drugs 0.000 description 1
- SYTBZMRGLBWNTM-UHFFFAOYSA-N flurbiprofen Chemical compound FC1=CC(C(C(O)=O)C)=CC=C1C1=CC=CC=C1 SYTBZMRGLBWNTM-UHFFFAOYSA-N 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- KWLMIXQRALPRBC-UHFFFAOYSA-L hectorite Chemical compound [Li+].[OH-].[OH-].[Na+].[Mg+2].O1[Si]2([O-])O[Si]1([O-])O[Si]([O-])(O1)O[Si]1([O-])O2 KWLMIXQRALPRBC-UHFFFAOYSA-L 0.000 description 1
- 229910000271 hectorite Inorganic materials 0.000 description 1
- 229960004867 hexetidine Drugs 0.000 description 1
- 235000001050 hortel pimenta Nutrition 0.000 description 1
- 239000000017 hydrogel Substances 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 1
- 229960001680 ibuprofen Drugs 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 229960000905 indomethacin Drugs 0.000 description 1
- 230000009878 intermolecular interaction Effects 0.000 description 1
- CSSYQJWUGATIHM-IKGCZBKSSA-N l-phenylalanyl-l-lysyl-l-cysteinyl-l-arginyl-l-arginyl-l-tryptophyl-l-glutaminyl-l-tryptophyl-l-arginyl-l-methionyl-l-lysyl-l-lysyl-l-leucylglycyl-l-alanyl-l-prolyl-l-seryl-l-isoleucyl-l-threonyl-l-cysteinyl-l-valyl-l-arginyl-l-arginyl-l-alanyl-l-phenylal Chemical compound C([C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 CSSYQJWUGATIHM-IKGCZBKSSA-N 0.000 description 1
- 239000000832 lactitol Substances 0.000 description 1
- 235000010448 lactitol Nutrition 0.000 description 1
- VQHSOMBJVWLPSR-JVCRWLNRSA-N lactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-JVCRWLNRSA-N 0.000 description 1
- 229960003451 lactitol Drugs 0.000 description 1
- 235000021242 lactoferrin Nutrition 0.000 description 1
- 229940078795 lactoferrin Drugs 0.000 description 1
- 235000010335 lysozyme Nutrition 0.000 description 1
- 229960000274 lysozyme Drugs 0.000 description 1
- 239000004325 lysozyme Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 239000001525 mentha piperita l. herb oil Substances 0.000 description 1
- 239000001683 mentha spicata herb oil Substances 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 229960000282 metronidazole Drugs 0.000 description 1
- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 229960001774 octenidine Drugs 0.000 description 1
- SMGTYJPMKXNQFY-UHFFFAOYSA-N octenidine dihydrochloride Chemical compound Cl.Cl.C1=CC(=NCCCCCCCC)C=CN1CCCCCCCCCCN1C=CC(=NCCCCCCCC)C=C1 SMGTYJPMKXNQFY-UHFFFAOYSA-N 0.000 description 1
- 229940049964 oleate Drugs 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- RARSHUDCJQSEFJ-UHFFFAOYSA-N p-Hydroxypropiophenone Chemical compound CCC(=O)C1=CC=C(O)C=C1 RARSHUDCJQSEFJ-UHFFFAOYSA-N 0.000 description 1
- 239000003002 pH adjusting agent Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
- 125000000864 peroxy group Chemical group O(O*)* 0.000 description 1
- ACVYVLVWPXVTIT-UHFFFAOYSA-M phosphinate Chemical compound [O-][PH2]=O ACVYVLVWPXVTIT-UHFFFAOYSA-M 0.000 description 1
- CBMSICGVCDVFQL-UHFFFAOYSA-N phosphonitrate Chemical compound [O-][N+](=O)OP(=O)=O CBMSICGVCDVFQL-UHFFFAOYSA-N 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 150000008442 polyphenolic compounds Chemical class 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- AVTYONGGKAJVTE-OLXYHTOASA-L potassium L-tartrate Chemical compound [K+].[K+].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O AVTYONGGKAJVTE-OLXYHTOASA-L 0.000 description 1
- 235000015497 potassium bicarbonate Nutrition 0.000 description 1
- 239000011736 potassium bicarbonate Substances 0.000 description 1
- 229910000028 potassium bicarbonate Inorganic materials 0.000 description 1
- 229940094025 potassium bicarbonate Drugs 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 229960002816 potassium chloride Drugs 0.000 description 1
- 239000001508 potassium citrate Substances 0.000 description 1
- 229960002635 potassium citrate Drugs 0.000 description 1
- QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 description 1
- 235000011082 potassium citrates Nutrition 0.000 description 1
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 1
- OQZCJRJRGMMSGK-UHFFFAOYSA-M potassium metaphosphate Chemical compound [K+].[O-]P(=O)=O OQZCJRJRGMMSGK-UHFFFAOYSA-M 0.000 description 1
- 229940099402 potassium metaphosphate Drugs 0.000 description 1
- 235000010333 potassium nitrate Nutrition 0.000 description 1
- 239000004323 potassium nitrate Substances 0.000 description 1
- 239000001472 potassium tartrate Substances 0.000 description 1
- 229940111695 potassium tartrate Drugs 0.000 description 1
- 235000011005 potassium tartrates Nutrition 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- LRGQZEKJTHEMOJ-UHFFFAOYSA-N propane-1,2,3-triol;zinc Chemical compound [Zn].OCC(O)CO LRGQZEKJTHEMOJ-UHFFFAOYSA-N 0.000 description 1
- 229960004063 propylene glycol Drugs 0.000 description 1
- 235000013772 propylene glycol Nutrition 0.000 description 1
- 150000003856 quaternary ammonium compounds Chemical class 0.000 description 1
- 230000008707 rearrangement Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229940084560 sanguinarine Drugs 0.000 description 1
- YZRQUTZNTDAYPJ-UHFFFAOYSA-N sanguinarine pseudobase Natural products C1=C2OCOC2=CC2=C3N(C)C(O)C4=C(OCO5)C5=CC=C4C3=CC=C21 YZRQUTZNTDAYPJ-UHFFFAOYSA-N 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 229940083542 sodium Drugs 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- GCLGEJMYGQKIIW-UHFFFAOYSA-H sodium hexametaphosphate Chemical compound [Na]OP1(=O)OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])O1 GCLGEJMYGQKIIW-UHFFFAOYSA-H 0.000 description 1
- 235000019982 sodium hexametaphosphate Nutrition 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229960003339 sodium phosphate Drugs 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 229910052712 strontium Inorganic materials 0.000 description 1
- CIOAGBVUUVVLOB-UHFFFAOYSA-N strontium atom Chemical compound [Sr] CIOAGBVUUVVLOB-UHFFFAOYSA-N 0.000 description 1
- 159000000008 strontium salts Chemical class 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 238000007910 systemic administration Methods 0.000 description 1
- 235000018553 tannin Nutrition 0.000 description 1
- 239000001648 tannin Substances 0.000 description 1
- 229920001864 tannin Polymers 0.000 description 1
- RYCLIXPGLDDLTM-UHFFFAOYSA-J tetrapotassium;phosphonato phosphate Chemical class [K+].[K+].[K+].[K+].[O-]P([O-])(=O)OP([O-])([O-])=O RYCLIXPGLDDLTM-UHFFFAOYSA-J 0.000 description 1
- YVDPOVXIRVBNAL-UHFFFAOYSA-J tetrapotassium;phosphonatooxy phosphate Chemical compound [K+].[K+].[K+].[K+].[O-]P([O-])(=O)OOP([O-])([O-])=O YVDPOVXIRVBNAL-UHFFFAOYSA-J 0.000 description 1
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
- 229940078499 tricalcium phosphate Drugs 0.000 description 1
- 235000019731 tricalcium phosphate Nutrition 0.000 description 1
- WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 description 1
- 229940045136 urea Drugs 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 239000004246 zinc acetate Substances 0.000 description 1
- 229960000314 zinc acetate Drugs 0.000 description 1
- 235000013904 zinc acetate Nutrition 0.000 description 1
- 239000011592 zinc chloride Substances 0.000 description 1
- 235000005074 zinc chloride Nutrition 0.000 description 1
- 229960001939 zinc chloride Drugs 0.000 description 1
- 239000011746 zinc citrate Substances 0.000 description 1
- 235000006076 zinc citrate Nutrition 0.000 description 1
- 229940068475 zinc citrate Drugs 0.000 description 1
- 239000011576 zinc lactate Substances 0.000 description 1
- 235000000193 zinc lactate Nutrition 0.000 description 1
- 229940050168 zinc lactate Drugs 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
- 229960001296 zinc oxide Drugs 0.000 description 1
- 235000014692 zinc oxide Nutrition 0.000 description 1
- OMSYGYSPFZQFFP-UHFFFAOYSA-J zinc pyrophosphate Chemical compound [Zn+2].[Zn+2].[O-]P([O-])(=O)OP([O-])([O-])=O OMSYGYSPFZQFFP-UHFFFAOYSA-J 0.000 description 1
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
- 229960001763 zinc sulfate Drugs 0.000 description 1
- 229910000368 zinc sulfate Inorganic materials 0.000 description 1
- VRGNUPCISFMPEM-ZVGUSBNCSA-L zinc;(2r,3r)-2,3-dihydroxybutanedioate Chemical compound [Zn+2].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O VRGNUPCISFMPEM-ZVGUSBNCSA-L 0.000 description 1
- 239000002888 zwitterionic surfactant Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
Abstract
包含酶、二氧化硅研磨剂、角叉菜聚糖和天然树胶的洁齿剂组合物，该天然树胶选自刺梧桐树胶、瓜尔胶、黄原胶、阿拉伯树胶、黄蓍胶以及它们的混合物，其中天然树胶与角叉菜聚糖的重量比为1∶3至1∶1。
Description
技术领域
本发明涉及包含酶的组合物。更具体地，本发明涉及含有酶的口腔护理组合物。
背景技术
含有酶的口腔护理组合物描述于EP3192496、EP3192495、EP 3192565和EP3192564中。然而，仍然需要配制具有增强的酶活性的组合物。
本申请涉及用于增强口腔护理产品中的酶的活性的组合物和方法。此外，本发明克服了一些牙膏配制物可能发生的脱水收缩问题。
发明内容
本发明涉及牙膏组合物，该牙膏组合物包含酶、包含脂肪醇的聚乙二醇醚的表面活性剂、二氧化硅研磨剂、角叉菜聚糖和天然树胶(natural gum)，该天然树胶选自刺梧桐树胶、瓜尔胶、黄原胶、阿拉伯树胶、黄蓍胶以及它们的混合物，其中黄原胶与角叉菜聚糖的重量比为1∶3至1∶1。
本发明还涉及1∶3至1∶1重量比的天然树胶和角叉菜聚糖在牙膏中减轻脱水收缩和增强酶活性的用途，其中所述天然树胶选自刺梧桐树胶、瓜尔胶、黄原胶、阿拉伯树胶、黄蓍胶以及它们的混合物。
为了避免疑问，本发明的一个方面的任何特征可用于本发明的任何其它方面。描述为“优选的”的任何特征应理解为与进一步优选的一个或多个特征的组合是特别优选的。本文中，特定实施方案的任何特征可用于本发明的任何其它实施方案中。词语“包含”旨在表示“包括”但不一定是“由…构成”或“由…组成”。换句话说，所列出的步骤或选项不需要是穷举的。以下描述中给出的实施例旨在阐明本发明而非限制本发明。除非另有说明，所有百分比均为重量/重量百分比。除了在操作例和对比例中，或另外明确指出的地方，本说明书中表示材料的量或反应条件、物理性质或材料和/或用途的所有数字应理解为由词语“约”修饰。除非另外规定，否则以格式'x至y'表示的数值范围应理解为包括x和y。当对于特定特征以格式'x至y'描述多个优选范围时，应理解也涵盖组合不同端点的所有范围。
本申请中命名的所有天然材料均源自欧洲的化学公司。
发明详述
根据本发明的组合物包含角叉菜聚糖。如果组合物包含大于角叉菜聚糖总含量的50重量％的λ-角叉菜聚糖，则是优选的。优选地，κ-角叉菜聚糖与λ-角叉菜聚糖的重量比为1∶3至2∶3，优选地，ι-角叉菜聚糖与λ-角叉菜聚糖的重量比为1∶6至1∶9。如果角叉菜聚糖包含λ-角叉菜聚糖、κ-角叉菜聚糖的混合物，则是优选的。还可以存在i-角叉菜聚糖。
优选地，角叉菜聚糖的含量为总组合物的0.1重量％至1.5重量％、更优选0.2重量％至1.0重量％。
本发明的组合物包含选自刺梧桐树胶、瓜尔胶、黄原胶、阿拉伯树胶和黄蓍胶的天然树胶，优选地本发明的组合物包含黄原胶。优选地，天然树胶、优选黄原胶的含量为总组合物的0.05重量％至1重量％，更优选为0.3重量％至0.7重量％。
本申请涉及包含酶的组合物，优选地所述组合物为个人护理组合物，更优选所述组合物为口腔护理组合物。本发明的组合物的优选产品形式是适于刷和/或冲洗口腔表面的那些。
本发明的组合物不出于治疗剂的全身施用目的而被有意吞咽，而是施用于口腔，用于处理口腔然后漱出。通常，这种组合物与清洁工具诸如牙刷结合使用，通常通过将其施用到牙刷的刷毛上，然后刷口腔的可及表面。
牙膏为可挤出的半固体形式，如膏体、糊状物或凝胶(或其混合物)。
根据本发明的组合物包含酶。优选地，所述酶选自以下组：
i)糖苷水解酶，更优选淀粉酶，最优选淀粉葡萄糖苷酶；
ii)作用于供体的OH基团的氧化还原酶，更优选以氧为受体的氧化酶，最优选葡萄糖氧化酶；
iii)血红素过氧化物酶(hemeperoxidase)，更优选卤代过氧化物酶，最优选乳过氧化物酶。
优选的是，如果所述酶是上述2种的混合物，更优选是上述3种的混合物，最优选是淀粉葡萄糖苷酶、葡萄糖氧化酶和乳过氧化物酶的混合物。
在本发明的上下文中，单独的葡萄糖氧化酶或酶混合物的葡萄糖氧化酶部分是特别优选的。
优选地，酶的总含量为总组合物的0.01重量％至2重量％。更优选地为总组合物的0.05重量％至1重量％。
优选地，组合物中糖苷水解酶的总含量为总组合物的0.05至1重量％。
优选地，作用于供体的OH基团的氧化还原酶的总含量为总组合物的0.05至1重量％。
优选地，血红素过氧化物酶的总含量为总组合物的0.0005重量％至0.01重量％。
优选地，组合物中糖苷水解酶与其它酶的重量比大于1∶1，更优选大于3∶2。
本发明的组合物还可以包含其它蛋白质，诸如溶菌酶、乳铁蛋白和初乳。优选地，这些其它蛋白质以总组合物的0.001至0.5重量％、优选总组合物的0.005至0.1重量％的总含量存在。
根据本发明的组合物包含二氧化硅。用于本发明中的优选的二氧化硅是具有低折射率的二氧化硅。它可用作唯一的研磨性二氧化硅使用，或与低含量的其它研磨性二氧化硅例如根据EP 236070的那些结合使用。在本发明中用作研磨剂的低折射率二氧化硅优选为这样的二氧化硅，其具有在1.41至1.47、更优选1.43至1.45的范围内的表观折射率(R.I.)，优选具有5至15μm的重均粒度，10至150m2/g的BET(氮)表面积，更优选约70-150cm3/100g的油吸收，但也可使用具有较低表观折射率的研磨性二氧化硅。合适的低折射率研磨性二氧化硅(例如具有在1.435和1.445之间的R.I.)的典型实例是购自Rhone Poulenc的Tixosil 63和73；购自Degussa的Sident10；购自Zeofinn的Zeodent 113；购自Huber的Zeodent 124、购自Crosfield Chemicals的Sorbosil AC 77(具有约1.440的R.I.)。这些二氧化硅在组合物中的量通常为总组合物的5至60重量％，更优选5至20重量％。
在一些实施方案中，如果将酶吸附/吸收到增稠二氧化硅上，则是优选的。优选地，所述二氧化硅具有小于150cm3/100g、更优选小于1cm3/100g的油吸收水平。特别优选的二氧化硅是Zeodent 165和Tixosil 43，因为这种类型的二氧化硅由于它们增强酶活性而优选。
所述口腔护理组合物将包含表面活性剂，所述表面活性剂包含按所述组合物的重量计0.2％至7％的量的脂肪醇的聚乙二醇醚。特别优选的是每单元具有20至40个环氧乙烷基团的聚乙二醇醚。这种合适的表面活性剂的实例包括被称为硬脂醇聚醚表面活性剂的表面活性剂组，如硬脂醇聚醚30。优选地，非离子表面活性剂的含量为总组合物的0.5至7重量％，更优选为总组合物的1至5重量％。
尽管可以存在其它表面活性剂，但如果将它们的含量限制在低于总组合物的0.5重量％、优选低于总组合物的0.1重量％，则是优选的。
在优选的产品形式中，基于组合物的总重量，按水和/或多元醇的总重量计，水和/或多元醇的量通常为至少10重量％、优选至少30重量％、更优选至少50重量％。优选地，水和/或多元醇的含量可以小于总组合物的90重量％、更优选小于85重量％。
根据本发明的洁齿剂组合物通常可包含各种相对量的水和多元醇的混合物作为含水连续相，其中水的量通常为10至50重量％(基于洁齿剂的总重量)，多元醇的量通常为20至60重量％(基于洁齿剂的总重量)。
用于根据本发明的口腔护理组合物中，特别是洁齿剂组合物中的典型多元醇包括湿润剂，诸如甘油、山梨醇、聚乙二醇、聚丙二醇、丙二醇、木糖醇(和其它可食用多元醇)、氢化的部分水解的多糖以及它们的混合物。甘油和山梨醇是优选的，山梨醇是特别优选的。
所述口腔护理组合物，特别是洁齿剂组合物包含研磨材料。基于洁齿剂的总重量，研磨材料通常以0.5至75重量％、优选以3至60重量％的量存在。合适的研磨性清洁剂包括二氧化硅干凝胶、水凝胶和气凝胶以及沉淀颗粒状二氧化硅；碳酸钙、磷酸二钙、磷酸三钙、煅烧氧化铝、偏磷酸钠和偏磷酸钾、焦磷酸钠和焦磷酸钾、三偏磷酸钠、六偏磷酸钠、颗粒状羟基磷灰石以及它们的混合物。二氧化硅是特别优选的，因为它们可以发挥研磨剂和增强酶活性的手段的双重作用。优选地，组合物，特别是牙膏包含如上所述的二氧化硅基研磨剂。
依赖于所选择的材料，该组合物可以包含总组合物的约0.10至约15重量％比例的附加的无机或天然或合成增稠剂或胶凝剂。可用于本发明实践的合适的增稠剂或胶凝剂包括细碎分散的二氧化硅、锂蒙脱石、碳酸钙、胶态硅酸镁铝以及它们的混合物。优选的是无机增稠二氧化硅，诸如以商品名称Zeodent 165获自Evonik的无定形二氧化硅。
本发明的组合物可包含金属离子诸如锡或锌。优选地，锌离子源是氯化锌、乙酸锌、葡萄糖酸锌、硫酸锌、氟化锌、柠檬酸锌、乳酸锌、氧化锌、单甘油酸锌、酒石酸锌、焦磷酸锌、马来酸锌以及它们的混合物。
本发明的组合物可包含氟化物源，诸如氟化钠、氟化亚锡、单氟磷酸钠、氟化锌铵、氟化锡铵、氟化钙、氟化钴铵以及它们的混合物。
本发明的组合物还可以含有本领域常规的其它任选成分，诸如抗微生物剂，例如氯己定、血根碱提取物、甲硝唑、季铵化合物诸如氯化十六烷基吡啶；双胍类，诸如氯己定二葡糖酸盐、海克替啶、奥替尼啶、阿来西定；和卤代双酚化合物，诸如2,2'-亚甲基双-(4-氯-6-溴苯酚)；
抗炎剂，诸如布洛芬、氟比洛芬、阿司匹林、吲哚美辛等；
抗龋齿剂，诸如氟化钠和氟化亚锡、氟化胺(aminefluoride)、单氟磷酸钠、三偏磷酸钠和酪蛋白；
牙斑缓冲剂，诸如尿素、乳酸钙、甘油磷酸钙和聚丙烯酸锶；
维生素类，诸如维生素A、维生素C和维生素E；
植物提取物；
植物可衍生的抗氧化剂，诸如类黄酮、儿茶素、多酚和单宁化合物以及它们的混合物；
脱敏剂，例如柠檬酸钾、氯化钾、酒石酸钾、碳酸氢钾、草酸钾、硝酸钾和锶盐；
抗牙结石剂，例如碱金属焦磷酸盐、含次磷酸盐的聚合物、有机膦酸酯和柠檬酸磷酸酯(phosphocitrate)等；
生物分子，例如细菌素、抗体、酶等；
风味剂，例如薄荷油和留兰香油；
蛋白质类物质诸如胶原；
防腐剂；
不透明剂；
氨基酸诸如精氨酸
着色剂；
pH调节剂；
甜味剂；
药学上可接受的载体，例如淀粉、蔗糖、水或水/醇体系等；
表面活性剂，诸如阴离子、非离子、阳离子和两性离子或两性表面活性剂；
湿润剂，诸如甘油、山梨醇、丙二醇、木糖醇、乳糖醇等；
还可以包括能够增强活性成分诸如抗微生物剂的递送的聚合化合物；
用以缓冲口腔护理组合物的pH和离子强度的缓冲剂和盐；并且
可以包括的其它任选成分是例如漂白剂诸如过氧化合物，例如过氧二磷酸钾，泡腾体系诸如碳酸氢钠/柠檬酸体系，变色体系等。
现在将通过以下非限制性实施例说明本发明：
具体实施方式
实施例
根据表1制备组合物。
表1
| 材料 | A | B | C | D | 1 |
| 山梨醇 | 28.5 | 28.5 | 28.5 | 28.5 | 28.5 |
| 葡萄糖酸锌 | 0.3 | 0.3 | 0.3 | 0.3 | 0.3 |
| 氟化钠 | 0.3 | 0.3 | 0.3 | 0.3 | 0.3 |
| 柠檬酸 | 0.3 | 0.3 | 0.3 | 0.3 | 0.3 |
| 磷酸二钠 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 |
| 二氧化钛 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 |
| Zeodent 113* | 16.0 | 16.0 | 16.0 | 16.0 | 16.0 |
| Tixosil 43** | 4.8 | 4.8 | 4.8 | 4.8 | 4.8 |
| 角叉菜聚糖 | 0.7 | 0.7 | 0.7 | 0.7 | 0.7 |
| 甘油 | 5.0 | 5.0 | 5.0 | 5.0 | 5.0 |
| 黄原胶 | 1.0 | 0 | 0.8 | 0.2 | 0.4 |
| 硬脂醇聚醚30 | 3.0 | 3.0 | 3.0 | 3.0 | 3.0 |
| 淀粉葡萄糖苷酶 | 0.3 | 0.3 | 0.3 | 0.3 | 0.3 |
| 葡萄糖氧化酶 | 0.14 | 0.14 | 0.14 | 0.14 | 0.14 |
| 水和微量物质 | 至100.0 | 至100.0 | 至100.0 | 至100.0 | 至100.0 |
(组合物含有1450ppm的作为NaF的F)
*沉淀二氧化硅
**增稠二氧化硅
聚合物凝胶的脱水收缩归因于聚合物凝胶的物理和化学性质随时间的变化。例如，聚合物凝胶的物理变化与聚合物的渗透压和弹性调节有关，这是由于聚合物链的重排而发生的。化学变化可与例如氢键或静电相互作用有关。所有这些物理-化学变化通过形成凝胶网络的聚合物链的聚集而导致聚合物基质的强化，这转而排斥出(expel)连续相。因此，控制聚合物链随时间的聚集过程限制了脱水收缩。测量脱水收缩和监测聚合物链的聚集过程的方法可以通过检查在短时间(即2至3小时)内经历热变化的糊状物的行为来进行。对样品进行热处理增加了物理和化学相互作用随时间变化的速率，因此可减少实验时间，这进而又增加实验产出。温度循环改变(即，破坏，形成或增强)聚合物链的相互作用和键合(即，疏水相互作用，氢键合等)。这些不同的相互作用导致结构和网络的变化，潜在地使糊状物不稳定。通过温度循环测量弹性模量(G')和粘性模量(G”)以及tanδ(＝G”/G')使得能够理解这些物理-化学变化。例如，G’随温度升高而降低突出了氢键的可逆断裂，导致更粘稠和液体状的样品。当温度冷却回去时，将发生新的分子间相互作用(离子和氢键合)，从而导致结构改变。结构的破坏程度使得能够估计更容易随时间而经历脱水收缩的样品。
为了比较，将检查G’随温度增加的变化(ΔG’)，以预测样品中发生的脱水收缩的程度：
表2总结了经历随ΔG’变化的脱水收缩的潜在样品的规则。
表2.观察的随ΔG’变化的脱水收缩的规则
在存在或不存在黄原胶下测量牙膏的弹性模量(G’)，对葡萄糖氧化酶的活性也如此。结果如表3中所示。
表3
表2表明，0重量％的黄原胶XG导致葡萄糖氧化酶GOx活性的显著改进，但脱水收缩增加。
表4.测量含有不同浓度的黄原胶([XG])的牙膏的弹性模量(ΔG')随温度升高的变化。还记载了葡萄糖氧化酶(GOx)的活性和每个样品的粘度。
表4
实施例证明本发明的实施例具有可接受的脱水收缩作用，而对酶活性没有不利影响。
Claims (14)
1.一种牙膏组合物，其包含酶、包含脂肪醇的聚乙二醇醚的表面活性剂、二氧化硅研磨剂、角叉菜聚糖和天然树胶，所述天然树胶选自刺梧桐树胶、瓜尔胶、黄原胶、阿拉伯树胶、黄蓍胶以及它们的混合物，其中所述天然树胶与角叉菜聚糖的重量比为1∶3至1∶1。
2.根据权利要求1所述的组合物，其中所述天然树胶与角叉菜聚糖的重量比为1∶2至1∶1。
3.根据前述权利要求中任一项所述的组合物，其中所述天然树胶为黄原胶。
4.根据前述权利要求中任一项所述的组合物，其中所述酶选自糖苷水解酶、作用于供体的OH基团的氧化还原酶、血红素过氧化物酶或它们的混合物。
5.根据前述权利要求中任一项所述的组合物，其中所述酶选自淀粉酶、以氧为受体的氧化酶、卤代过氧化物酶或它们的混合物。
6.根据前述权利要求中任一项所述的组合物，其中所述酶选自淀粉葡萄糖苷酶、葡萄糖氧化酶、乳过氧化物酶或它们的混合物。
7.根据前述权利要求中任一项所述的组合物，其中所述酶或酶混合物包含葡萄糖氧化酶。
8.根据前述权利要求中任一项所述的组合物，其中所述组合物包含前述权利要求任一项中所描述的两种酶的混合物。
9.根据前述权利要求中任一项所述的组合物，其中所述组合物包含前述权利要求任一项中所描述的三种酶的混合物。
10.根据前述权利要求中任一项所述的组合物，其进一步包含增稠二氧化硅。
11.根据前述权利要求中任一项所述的组合物，其中所述角叉菜聚糖包含角叉菜聚糖总含量的至少50重量％的λ-角叉菜聚糖。
12.根据前述权利要求中任一项所述的组合物，其中所述角叉菜聚糖包含9∶4∶1至6∶3∶1重量比的λ-角叉菜聚糖、κ-角叉菜聚糖和i-角叉菜聚糖。
13.根据前述权利要求中任一项所述的组合物，其中所述脂肪醇的聚乙二醇醚每单元包含20至40个环氧乙烷基团。
14.以1∶3至1∶1的重量比的天然树胶和角叉菜聚糖在牙膏中用以减轻脱水收缩和增强酶活性的用途，其中所述天然树胶选自刺梧桐树胶、瓜尔胶、黄原胶、阿拉伯树胶、黄蓍胶以及它们的混合物。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP20163716.2 | 2020-03-17 | ||
| EP20163716 | 2020-03-17 | ||
| PCT/EP2021/056571 WO2021185783A1 (en) | 2020-03-17 | 2021-03-15 | Composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN115297825A true CN115297825A (zh) | 2022-11-04 |
Family
ID=69845255
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202180021738.4A Pending CN115297825A (zh) | 2020-03-17 | 2021-03-15 | 组合物 |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP4120992B1 (zh) |
| CN (1) | CN115297825A (zh) |
| BR (1) | BR112022016907A2 (zh) |
| WO (1) | WO2021185783A1 (zh) |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001114659A (ja) * | 1999-10-13 | 2001-04-24 | Lion Corp | 口腔用組成物 |
| JP2016204330A (ja) * | 2015-04-27 | 2016-12-08 | サンスター株式会社 | 舌苔除去用ゲルを調製するための組成物、及び舌苔除去用ゲル |
| CN106470662A (zh) * | 2014-05-07 | 2017-03-01 | 宝洁公司 | 口腔护理组合物 |
| EP3192496A1 (en) * | 2016-01-12 | 2017-07-19 | Unilever PLC | Oral care compositions |
| EP3192497A1 (en) * | 2016-01-12 | 2017-07-19 | Unilever PLC | Oral care composition comprising an enzyme and a natural gum |
| CN107007538A (zh) * | 2017-03-03 | 2017-08-04 | 广州薇美姿实业有限公司 | 一种含海洋元素的口腔护理组合物和应用，及含海洋元素的牙膏 |
| CN110636831A (zh) * | 2017-05-11 | 2019-12-31 | 荷兰联合利华有限公司 | 口腔护理组合物 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8604985D0 (en) | 1986-02-28 | 1986-04-09 | Unilever Plc | Precipitated silicas |
| EP3192495A1 (en) | 2016-01-12 | 2017-07-19 | Unilever PLC | Oral care compositions |
| EP3192564A1 (en) | 2016-01-12 | 2017-07-19 | Unilever PLC | Oral care composition comprising a protein for balancing the bacterial flora of the mouth |
| EP3192565B1 (en) | 2016-01-12 | 2021-11-10 | Unilever IP Holdings B.V. | Oral care composition comprising a protein for balancing the bacterial flora of the mouth |
-
2021
- 2021-03-15 BR BR112022016907A patent/BR112022016907A2/pt unknown
- 2021-03-15 WO PCT/EP2021/056571 patent/WO2021185783A1/en unknown
- 2021-03-15 EP EP21711267.1A patent/EP4120992B1/en active Active
- 2021-03-15 CN CN202180021738.4A patent/CN115297825A/zh active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001114659A (ja) * | 1999-10-13 | 2001-04-24 | Lion Corp | 口腔用組成物 |
| CN106470662A (zh) * | 2014-05-07 | 2017-03-01 | 宝洁公司 | 口腔护理组合物 |
| JP2016204330A (ja) * | 2015-04-27 | 2016-12-08 | サンスター株式会社 | 舌苔除去用ゲルを調製するための組成物、及び舌苔除去用ゲル |
| EP3192496A1 (en) * | 2016-01-12 | 2017-07-19 | Unilever PLC | Oral care compositions |
| EP3192497A1 (en) * | 2016-01-12 | 2017-07-19 | Unilever PLC | Oral care composition comprising an enzyme and a natural gum |
| CN107007538A (zh) * | 2017-03-03 | 2017-08-04 | 广州薇美姿实业有限公司 | 一种含海洋元素的口腔护理组合物和应用，及含海洋元素的牙膏 |
| CN110636831A (zh) * | 2017-05-11 | 2019-12-31 | 荷兰联合利华有限公司 | 口腔护理组合物 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP4120992B1 (en) | 2023-11-22 |
| BR112022016907A2 (pt) | 2022-10-25 |
| WO2021185783A1 (en) | 2021-09-23 |
| EP4120992A1 (en) | 2023-01-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ZA200502420B (en) | Antiplaque enzyme containing dual component composition | |
| US20080152601A1 (en) | Dual Component Dental Composition Containing Enzyme | |
| CN115297825A (zh) | 组合物 | |
| WO2023094383A1 (en) | Oral care composition comprising a bipolar composite material | |
| CN114585418A (zh) | 口腔护理组合物 | |
| EP3955883B1 (en) | A personal care composition comprising tetramethylcurcumin and process for producing the composition | |
| EP3955884B1 (en) | A personal care composition comprising piperlongumine and process for producing the composition | |
| CN114096225B (zh) | 包含姜二醇的口腔护理组合物及制备该组合物的方法 | |
| RU2801309C2 (ru) | Композиция для ухода за полостью рта | |
| CN110868998A (zh) | 牙膏组合物 | |
| WO2023186746A1 (en) | An oral care composition | |
| WO2023186583A1 (en) | An oral care composition | |
| WO2023186648A1 (en) | An oral care composition | |
| CN116981440A (zh) | 口腔护理组合物 | |
| WO2024104743A1 (en) | Oral care composition | |
| WO2024046751A1 (en) | Process for the manufacture of a non-aqueous composition | |
| WO2023247290A1 (en) | Oral care composition for mitigation and/or reverstion of erosion of tooth enamel caused by wearing an aligner | |
| WO2023213460A1 (en) | Oral care composition | |
| WO2023247292A1 (en) | Oral care composition for mitigation and/or reversion of erosion of tooth enamel caused by wearing an aligner | |
| WO2023247291A1 (en) | Oral care composition for mitigation and/or reversion of erosion of tooth enamel caused by wearing an aligner | |
| WO2023138811A1 (en) | Oral care composition | |
| WO2023138996A1 (en) | Oral care composition | |
| WO2023227282A1 (en) | Oral care composition |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |