CN1152882A - Low drag syringe and cartridge - Google Patents
Low drag syringe and cartridge Download PDFInfo
- Publication number
- CN1152882A CN1152882A CN95193831A CN95193831A CN1152882A CN 1152882 A CN1152882 A CN 1152882A CN 95193831 A CN95193831 A CN 95193831A CN 95193831 A CN95193831 A CN 95193831A CN 1152882 A CN1152882 A CN 1152882A
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- China
- Prior art keywords
- plunger
- syringe
- far
- plunger rod
- rod
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
- A61M5/31513—Piston constructions to improve sealing or sliding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M2005/3112—Incorporating self-aspirating means, e.g. to provide flashback
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- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
The invention provides a syringe comprising a barrel, a plunger and a plunger rod. The plunger can be deformed by the plunger rod to draw the radial walls of the plunger away from the inner wall of the barrel and thus reduce the friction between the plunger and the barrel, to facilitate injection. The deformation can also be used to aspirate the syringe. The invention also provides a method of delivering a liquid medium into a patient using such a syringe.
Description
The syringe of relate generally to prefilled of the present invention and the syringe of prefilled are so that be used for various liquid infusions in the patient body, more specifically say, the present invention relates to the syringe of plastics and syringe in case be used for medicine biological preparation with liquid as the diagnosis dye injection in the patient body.
Known have various syringes to can be used to the extracting bodily fluid sample or liquid preparation injected to patient.These syringes generally all have the syringe cylinder of a cylindrical shape, a subcutaneous injection that is contained on the syringe cylinder is located at plunger in the syringe cylinder with pin and one, just causes a suction body fluid can be pumped in the tube or by hypodermic needle when the operator is applied to a power on the plunger vertically liquid preparation is penetrated.The purpose of plunger is to set up gas-tight seal between plunger itself and syringe cylinder, and plunger moving up and down in tube can be sucked liquid, blood or other fluids or extrude from syringe by far-end.
The syringe that is used for this purpose comprises glass syringe, and wherein the cylindrical shape tube is made by glass, and plunger is one to fit snugly in the glass rod of the polishing in the cylindrical shape tube.Simultaneously resistance to be reduced to an acceptable level in order stopping a leak, between tube and plunger, except with lubricator, also tolerance closely must to be arranged.This glass syringe has many shortcomings: because they need tolerance closely, they are more expensive; They are difficult for mass production, because plunger often can not exchange, manufacturer must make plunger cooperate with cylindrical shell one by one in the process of grinding; And break easily.
In order to eliminate these problems, suggestion once and/or actual like this manufacturing are promptly adopted cylindrical shell and the plastics or the elastomeric plunger of glass and plastics.In order to prevent the leakage around the plunger, on plunger, be shaped on one or more rib, this rib has than the inboard bigger diameter of cylindrical shell at uncompressed state, just is compressed and is out of shape and is pressed on the barrel in the time of therefore in being placed into cylindrical shell, thereby form sealing.The quality of sealing and intensity depend on elastomer performance and plunger and inboard both diameter ratios of cylindrical shell of making the plunger material therefor.In order to obtain a good leakproof seal, injector cartridge must be applied to bigger compression stress on the elastomeric plunger.But such airtight quality makes plunger be difficult to move in cylindrical shell, and the operator must just can make plunger move with more power.This shortcoming is more obvious to the syringe of storing stand-by prefilled, because can block in cylindrical shell at memory period plunger on the frame.In order to remedy this problem, prior art makes friction and the resistance that with lubricator reduces between plunger and syringe cylinder inboard.The common for this purpose a kind of lubricant that uses is silicone oil.But use this lubricant not welcome,, thereby prescription is polluted because this lubricant can disperse and/or be dissolved in the prescription without the intestines and stomach.That yes is undesirable in this potential doping, so people once attempted exploring not with lubricator and syringe still can leakproof and method that plunger is slided easily.This trial comprises adopts various plunger profile, wherein have a kind of be provided with on the plunger one or more in cylindrical shell to the front or rear rib that stretches out so as to reducing the frictional resistance between plunger and cylindrical shell.Another kind method is for example at United States Patent (USP) 5,009, and is disclosed in No. 646, is with the thin film of tetrafluoroethene, ethyl tetrafluoroethene and extra high molecular weight ethylene resin the elastomer plunger to be made hierarchy.
Be used for extracting bodily fluid sample or with regard to the syringe of injection medicament the storage tube with regard to design, though how many fluid tightness and sliding capabilities improve after adopting above-mentioned these to attempt, but in the syringe of the prefilled of prolonged storage, the inappropriate problem of sliding capability still is not resolved.
A main purpose of the present invention is that a kind of syringe of prefilled and the syringe of prefilled will be provided, and it can solve the inappropriate problem of above-mentioned sliding capability, keeps tight leak proof seal simultaneously between plunger and syringe barrel.
It is the syringe and the syringe that will provide a kind of energy oneself to suck that some preferred embodiment of the present invention also has a purpose.
In medical practice, subcutaneous injection is in subcutaneous or intramuscular injection sometimes, but must be in intravenous injection in the time of other, and this will see the medicament that specifically will inject how.With regard to both of these case, before injection medicament, the injector always should know for certain that his hypodermic needle is that the position is in main blood vessel such as intravenous or subcutaneous tissue.Adopting a kind of inhalation syringe that can produce negative pressure within it just to can be to make a kind of like this decision provides means.Show that when in syringe, blood occurring syringe needle shows then that when not having blood to occur the syringe needle position is in subcutaneous tissue in the position in main blood vessel owing to negative pressure.According to the classification of the injection that will carry out, so but just direct injection perhaps syringe needle is extracted out, reorientate.
Inhalation syringe generally has two kinds of patterns, and a kind of is manually to suck, and another kind is to suck automatically.In the pattern that manually sucks, must be with the distance of one section weak point of the intravital plunger retraction of syringe cylinder.Indentation reduces the pressure in the syringe, body fluid is drawn into from the syringe needle in the syringe cylinder and can be observed.But, then there is not body fluid to be inhaled in the tube if syringe needle inserts in the solid subcutaneous tissue.Must hold tube-holding body for one with two handss when injecting with manual inhalation syringe, the another hands is applied to pressure on the plunger on direction backward.The shortcoming of this manually operated inhalation syringe is the proficiency level that the injector is depended in their appropriate use to a great extent.
In the suction that sucks automatically or certainly in the syringe is to implement like this, at first introduces a positive pressure on the part that contains medicament of syringe, removes the power of introducing malleation then, just can produce a corresponding negative pressure in syringe, makes to suck to be achieved.Some more excellent embodiment of the present invention just relates to this syringe from suction-type.
Ideally should accomplish from sucking hypodermic syringe: construct fairly simple so that make producing cost as much as possible little; Operate fairly simple; The enough manual operatings of energy; Suitable repeatedly carrying out from sucking action; And can be inserted into injection position and beginning at pin carried out before sucking action the air that will be absorbed in and gets rid of in the syringe and can not need therefore becoming and can not operate from sucking action or making from sucking in the time cancellation of the back of operating sequence.
The withdrawal action that the plunger that some preferred embodiment of the present invention can be simulated the manual operation syringe automatically moves after slightly makes to produce in the syringe to suck required small negative pressure like this.Therefore these syringes can be eliminated the intrinsic shortcoming of manual type syringe of prior art, because suction action can produce automatically, the injector can not need professional skill.
The present invention describes with reference to the syringe of prefilled; But should know that the present invention also can be applicable to have the prefilled syringe with the essentially identical shape of prefilled syringe and other features.Therefore should be appreciated that employed in the claims " syringe " speech its implication except syringe also should comprise syringe.
According to first aspect of the present invention, the syringe that is provided has a cylindrical shell, a plunger and a plunger rod, but said plunger rod actuation plunger makes plunger distortion still remain on sealing between cylindrical shell inboard and the plunger so as to reducing the friction between cylindrical shell inboard and plunger.
According to second aspect of the present invention, the syringe that is provided be designed to be full of in advance the storage and can be stand-by immediately.This syringe has:
(a) cylindrical shell, its inner surface forms a cylindrical shape chamber and is used for keeping injection; The tip that its far-end becomes a band tapering is used for adorning entry needle; Its near-end is used for admitting a plunger;
(b) ring-type plunger is contained in the said cylindrical shell slidably, and the position is near the near-end of cylindrical shell, constitutes sealing between it and cylinder inner surface, and said plunger has:
The convex surface of (1) far-end becomes the interface that contacts with injection in the cylindrical shell;
(2) proximal end faces;
(3) lateral walls that are connected with the far-end convex surface have on it: distal loop, proximal loop and adapter ring, these rings are radially outwards given prominence to and are constituted a slidably sealing with cylinder inner surface;
(4) medial walls;
(5) foundation rings, it forms the cavity of a receive posts stoppering with the medial wall;
(c) one has far-end and near-end and the position inflexible plunger stopper in said cavity, and this plunger stopper has: the medial wall of a band female thread is so that the pin thread on admittance and the joggle post stopper rod; Position is in the bead of near-end, and its diameter is greater than the interior diameter of plunger foundation ring, and therefore said plunger stopper can be clamped in the said cavity securely; And
(d) one has the plunger rod that far-end and near-end can be used to mesh plunger, and this plunger rod has:
(1) shoulder that is located at the plunger rod far-end, when being inserted into plunger rod in the plunger, this shoulder contacts with the foundation ring of plunger so that limit the prolongation of plunger;
(2) cervical regions with plunger rod front end adjacency, which is provided with pin thread in case with the plunger stopper on the female thread engagement; And
(3) plunger rod front ends that give prominence to forward on the direction of plunger rod far-end at plunger the position,
According to the 3rd aspect of the present invention, the syringe that is provided be designed to be full of in advance the storage and can be stand-by immediately.This syringe has:
(a) cylindrical shell, its inner surface forms a cylindrical shape chamber and is used for keeping injection; The tip that its far-end becomes a band tapering is used for adorning entry needle; Its near-end is used for admitting a plunger;
(b) cup-shaped plunger is contained in the said cylindrical shell slidably, and the position is near the near-end of cylindrical shell, constitutes sealing between it and cylinder inner surface, and said plunger has:
The convex surface of (1) far-end becomes the interface that contacts with injection in the cylindrical shell;
The inner plane or the inner concave of (2) parallel with the far-end convex surface basically near-ends;
(3) lateral walls that are connected with the far-end convex surface have on it: distal loop, proximal loop and adapter ring, these rings are radially outwards given prominence to and are constituted a slidably sealing with cylinder inner surface;
(4) medial walls which is provided with female thread;
(5) foundation rings, it forms one with the medial wall and can insert so that the circular hole that engages for plunger rod in the cup-shaped plunger; And
(c) one has far-end and near-end, is used for plunger rod with plug engages, and this plunger rod has:
(1) position is at the plunger rod front end face of plunger rod far-end, has on the plunger direction the semicircle convex surface of projection forward, and its diameter is obviously less than the diameter of plunger, and is designed to contact with the plane or the concave surface of plunger central part near-end inboard;
(2) cervical regions with plunger rod front end face adjacency, design is used for admitting a slidably cylinder;
(3) the slidably cylinders of position around cervical region, this cylinder has a medial wall and a lateral wall, the medial wall forms a cylinder, its diameter less than the diameter of plunger rod front end face so that prevent that slidably cylinder skids off from cervical region, the lateral wall is provided with pin thread and can meshes with the female thread on the plunger, so that can be used to operating syringe when being inserted into plunger rod in the plunger.
According to the 4th aspect of the present invention, the syringe that is provided be designed to be full of in advance the storage and can be stand-by immediately.This syringe has:
(a) cylindrical shell, its inner surface forms a cylindrical shape chamber and is used for keeping injection; The tip that its far-end becomes a band tapering is used for adorning entry needle; Its near-end is used for admitting a plunger;
(b) cup-shaped plunger is contained in the said cylindrical shell slidably, and the position is near the near-end of cylindrical shell, constitutes sealing between it and cylinder inner surface, and said plunger has:
The convex surface of (1) far-end becomes the interface that contacts with injection in the cylindrical shell;
(2) proximal end faces;
(3) lateral walls that are connected with the far-end convex surface have on it: distal loop, proximal loop and adapter ring, these rings are radially outwards given prominence to and are constituted a slidably sealing with cylinder inner surface;
(4) medial walls that are provided with female thread thereon; And
(5) foundation rings, it forms one with the medial wall and can insert so that the circular hole that engages for the plunger application cylinder in the cup-shaped plunger;
(c) one has far-end and near-end, is used for plunger application cylinder with plug engages, and this application cylinder has:
(1) be located at far-end be used for plunger on the pin thread of female thread engagement; And
(2) handles that are located at near-end; And
(d) one has far-end and near-end and is contained in plunger rod in the said plunger application cylinder, and this plunger rod has:
(1) one is located at far-end and has on the plunger direction the semicircle front end face of projection forward, and its diameter is obviously less than the diameter of plunger, so that add on the proximal end face that is pressed in plunger when being applied to pressure on the plunger rod;
(2) one are located at near-end and the position button outside the plunger application cylinder, are used as first arresting stop of plunger rod and so that be used for limiting moving of plunger rod it are extend in the proximal end face of plunger; And
(3) one also are provided in a side of near-end but stand away with button and the bead of position in the plunger application cylinder, are used as second arresting stop of plunger so that be used for limiting plunger rod moving on the direction of plunger application cylinder near-end;
Said first arresting stop and second arresting stop are designed to plunger rod mobile in the plunger application cylinder is limited in one by in the predetermined length that distance limited between first and second arresting stops.
To be to illustrate that as an example preferred embodiment of the present invention also carries out in conjunction with the accompanying drawings now, wherein:
Fig. 1 is for having plunger and plunger stopper but the decomposition diagram of first embodiment of the syringe that plunger rod has been removed according to of the present invention;
Fig. 2 is the syringe got along 2-2 line among Fig. 1 and the longitudinal section of plunger;
Fig. 3 is the profilograph of the plunger rod got along 2-2 line among Fig. 1;
Fig. 4 is the plunger got along 2-2 line among Fig. 1 and the decomposing section of plunger stopper;
Fig. 5 is the plunger got along 2-2 line among Fig. 1 and the cutaway view of plunger stopper;
Fig. 6 is the partial, longitudinal cross-sectional along the syringe of 2-2 line among Fig. 1, plunger, plunger stopper and plunger rod;
Fig. 7 is the perspective view according to the syringe that has assembled that has plunger and plunger rod of second embodiment of the invention;
Fig. 8 is for syringe, the plunger got along 8-8 line among Fig. 7 and slidably cylindrical plunger rod and plunger and plunger rod are housed have been inserted in partial, longitudinal cross-sectional in the syringe;
Fig. 9 is the partial cutaway view of the amplification of plunger rod among Fig. 7;
Figure 10 is the plunger rod among Fig. 7 and the partial sectional view of the amplification of plunger when plunger rod does not dock;
Figure 11 is the partial sectional view of the amplification of plunger rod among Fig. 7 and plunger, the dynamic expression that plunger rod and plug engages plunger circumference are dwindled.
Figure 12 is the plunger rod among Fig. 7 and the fragmentary, perspective view of the amplification of cylinder when plunger rod partly is inserted in the cylinder slidably slidably;
Figure 13 is the plunger rod among Fig. 7 and the perspective view of the amplification of cylinder when plunger rod inserts in the cylinder slidably fully slidably;
Figure 14 is the plunger rod of Figure 12 and slidably cylindrical side view;
Figure 15 is the plunger rod of Figure 13 and slidably cylindrical side view;
Figure 16 for plunger rod will be slidably side view when cylinder is removed;
Figure 17 is the slidably cylindrical side view that is provided with pin thread;
Figure 18 is the slidably cylindrical top view of Figure 17;
Figure 19 is the partial, longitudinal cross-sectional of syringe, plunger and the plunger rod of one typical, prior art;
Figure 20 be the plunger of prior art of Figure 19 and plunger rod amplification, part sectioned view;
Figure 21 is the perspective view with injector cartridge, plunger, plunger application cylinder and syringe plunger rod, that assembled according to the third embodiment of the present invention;
Figure 22 is the profilograph of the plunger got along 22-22 line among Figure 21;
Figure 23 is the profilograph of the plunger application cylinder got along 22-22 line among Figure 21;
Figure 24 is the profilograph of the plunger rod got along 22-22 line among Figure 21;
Figure 25 is the part sectioned view of the amplification of plunger application cylinder;
Figure 26 is for having injector cartridge, plunger, plunger application cylinder and syringe plunger rod, that assembled longitudinal section of being got along the 22-22 line when plunger rod is in home position among Figure 21;
Figure 27 is for having injector cartridge, plunger, plunger application cylinder and syringe plunger rod, that assembled longitudinal section of being got along the 22-22 line when plunger rod is in extended position among Figure 21;
Figure 28 is the part sectioned view of the amplification of plunger, plunger application cylinder and plunger rod when plunger rod is in home position; And
Figure 29 is the part sectioned view of the amplification of plunger, plunger application cylinder and plunger rod when plunger rod is in extended position.
Consulting Fig. 1, shown in it is 10 syringe according to the label first embodiment of the present invention, total, and this syringe has: cylindrical shell 20, plunger 30 and plunger rod 50.
Consult Fig. 1,2 and 3, syringe 10 has: a cylindrical shell 20 has medial wall 21, a far-end and the near-end 24 that is used for admitting plunger 30 that a through hole 23 is arranged with tip 22 endings of band tapering on it; Be located at the plunger 30 in the cylindrical shell 20 slidably; And can be contained in plunger rod 50 on the plunger 30.Being located at around cylindrical shell 20 near-ends 24 periphery is finger-like bead 26, and it is convenient to clamping cylindrical shell 20 during operating plunger 30 on the plunger rod 50 in that power is applied to.Plunger rod 50 also has handle 62 so that be convenient to plunger rod 50 power is applied on the plunger 30 when operating syringe except that far-end 52 and near-end 60 are arranged.
Syringe cylinder 20 is by the material such as the glass of saturating noble gas are not made.But the most handy substantial transparent and making than glass how many more flexible materials is as the polymer of polyethylene, polypropylene, polystyrene, acrylic acid and metering system.
Consult Fig. 1,2,3,4 and 6, plunger 30 is installed in the cylindrical shell 20 slidably, and can move vertically in cylindrical shell 20 on the plunger rod 50 that is applied to manpower with plunger 30 engagement the time.Just as an inverted cup, it has plunger 30 under its relaxed state: the outer convex surface 32 of a far-end; The medial surface 34 of a near-end; The lateral wall 36 that is connected with the outer convex surface 32 of far-end; The medial wall 38 that is connected with inner face 34; With the root edge 39 that on cup-shaped plunger 30, forms circular hole.The far-end convex surface 32 of plunger 30 becomes the interface that contacts with liquid in the cylindrical shell 20.
The lateral wall 36 of plunger 30 has: distal loop 40, proximal loop 41 and adapter ring 42, these encircle elastically deformable, and all radially from lateral wall 36, outwards give prominence to, and when connecting together, has an also bigger minimum diameter of maximum gauge than cylindrical shell 20 active sections with plunger 30.These rings constitute sealing but engage with the medial wall 21 of cylindrical shell 20 slidably.
Medial wall 38, medial surface 34 and root edge 39 form a three-dimensional cavity or regional so that admit the plunger stopper 68 of plunger 30.
Plunger stopper 68 is made polymer as polyethylene, polypropylene, polystyrene, acrylic acid and metering system by inflexible polymeric material.It has: lateral wall 74; Which is provided with female thread 69 so as to admit plunger 50 and with its on the medial wall 72 of pin thread 71 engagements; With bead 70.Plunger stopper 68 is located at the 3D region that is formed by medial wall 38, medial surface 34 and foundation ring 39 is surrounded plunger stopper 68 fully.But the size of plunger stopper 68 can not be applied to pressure on the medial wall 38, so the lateral wall of plunger 36 has enough spaces and can make a concession in the medial wall along side direction from syringe cylinder.The diameter of plunger stopper 68 is greater than the aperture of the foundation ring 39 of plunger 30, so plunger stopper 68 can not skid off from plunger 30.
Present embodiment is following to be operated:
The syringe of the sterilization of prefilled separates packing so that assemble with hypodermic needle and plunger rod then before being about to use.When preparing injection with hypodermic needle by on the band tapering far-end that is pressed in cylindrical shell.Be contained in being threaded into of plunger rod 50 in the plunger stopper 68 in plunger 30 cavitys and tighten up.The injector is inserted into entry needle in the required human body such as blood vessel with traditional venipuncture technology then.The female thread 69 of plunger stopper 68 meshes with the pin thread 71 of plunger rod 50 at that time, and plunger rod front end 64 contacts with the medial surface 34 of plunger 30.
When the operator when on the direction of far-end, being applied to a less pressure on the plunger rod 50, plunger will take place to be listed in down on the circumference distortion as shown in Figure 6: the convex surface 32 of plunger 30 will be to remote extension, and distal loop 40, proximal loop 41 and adapter ring 42 will be pulled to the inboard by elastic pulling force.The distortion of this of plunger on circumference will make the gas of front discharge in syringe, is about to gas and extracts out in syringe.When unclamping the pressure that is applied on the plunger rod 50, plunger 30 turns back to its static position, thereby causes a vacuum and extract body fluid on one's body out from patient in cylindrical shell 20, and this body fluid can indicate entry needle to enter desired area, and injection can begin.Also can finish suction to the near-end pulling plunger of cylindrical shell by plunger rod.During the pulling plunger rod, 68 on plunger stopper is applied to power on the foundation ring 39 of plunger 30, and therefore in this suction, foundation ring 39 becomes the first guide margin of plunger 30.Plunger just can extend in the axial direction allows manual aspiration is carried out easily like this.
After finishing aspiration procedure, the operator is applied to pressure on the plunger rod 50.Circumferential deformation takes place in proximal loop 41, distal loop 40 and adapter ring 42 at that time, and obviously, the power that these rings act on cylindrical shell 20 medial walls 21 now is reduced, and this minimizing is directly proportional with the circumferential deformation of these rings.As a result, plunger just can more easily move in cylindrical shell liquid can be injected in the injection site easily.Plunger blocks easily in cylindrical shell when the prolonged storage of syringe of prefilled, power on the interface between plunger and the cylindrical shell medial wall makes both be difficult to separate in the axial direction, at this moment above-mentioned advantage is more obvious, because in said syringe, the power that is applied on the plunger can pull to the inboard with distal loop, proximal loop and adapter ring, thereby can significantly reduce the power on the interface between plunger and the cylindrical shell medial wall.
Consult Fig. 7 and 8 now, it shown in it is 110 syringe according to the label second embodiment of the present invention, total, this syringe has: a cylindrical shell, medial wall 121 is arranged on it, one becomes the tip 122 of being with tapering and far-end and the near-end 124 that is used for admitting plunger 130 with a through hole 123; Be located at the plunger 130 in the cylindrical shell 120 slidably; And can be contained in plunger rod 150 on the plunger 130.Be located at finger-like beads 126 around cylindrical shell 120 near-ends 124 periphery and can be power being applied on the plunger rod 150 be convenient to clamping cylindrical shell 120 during operation plunger 130.Plunger rod 150 also has handle 162 so that be convenient to plunger rod 150 power is applied on the plunger 130 when operating syringe except that far-end 152 and near-end 160 are arranged.
Consult Fig. 7,9 and 10, plunger 130 be received within slidably in the cylindrical shell 120 and can be on the plunger rod 150 that is applied to manpower with plunger 130 engagements the time in cylindrical shell 120 along moving axially.Just as an inverted cup, it has plunger 30 under its relaxed state: the outer convex surface 132 of a far-end; Basically the inner plane or the inner concave 134 of the near-end parallel with the outer convex surface of far-end 132; The lateral wall 136 that is connected with the outer convex surface 132 of far-end; The medial wall 138 that is connected with said inner plane or inner concave 134; With the foundation ring 139 that on cup-shaped plunger 130, forms circular hole.The far-end convex surface 132 of plunger 130 becomes the interface that contacts with liquid in the cylindrical shell 120.
The lateral wall 136 of plunger 130 has distal loop 140, proximal loop 141 and adapter ring 142, these ring elastically deformables are also all radially outwards given prominence to from lateral wall 136, and have an also bigger minimum diameter of maximum gauge than cylindrical shell 120 active sections when connecting together with plunger 130.These rings constitute sealing but engage with the medial wall 121 of cylindrical shell 120 slidably.
The medial wall 138 of plunger 130 have female thread 143 in case admit plunger rod 150 and with its pin thread 170 engagements.
Consult Fig. 9,10,12,13,14,15,17 and 18, plunger rod 150 has: the handle 162 that is located at its near-end 160 is so that the operator can apply power thereon easily; Outstanding forward and have a plunger rod front end 164 of semicircle convex surface on the direction of plunger, it has an obvious diameter littler than plunger, the position is at the far-end 152 of plunger rod 150, from the elongation forward vertically of this far-end, and suit to contact so that pressure is applied on the plunger 130 with the inner plane or the inner concave 134 of plunger 130 central parts; The position suits to admit a slidably cylinder 168 at the plunger rod front end 164 of plunger rod 150 and the cervical region 166 of the plunger rod 150 between the far-end 152, and this cylinder has lateral wall 174 and medial wall 172.Lateral wall 174 is provided with pin thread 170 and can meshes with the female thread on the plunger 130.Medial wall 172 forms a cylinder, and its interior diameter is slightly less than the diameter of plunger rod front end 164 and skids off from the cervical region 166 of plunger rod 150 so that prevent cylinder 168 slidably.
Present embodiment is following to be operated:
Also having an alternative perfusion program in addition is the tip 122 of band tapering is sealed and from the near-end perfusion medicament of cylindrical shell 120, plunger 130 to be inserted in the cylindrical shell 120 after being full of syringe 110 again.
The syringe of the sterilization of prefilled separates packing so that assemble with hypodermic needle then before being about to use.When preparing injection hypodermic needle is installed on the far-end 122 of band tapering of cylindrical shell 120.Slidably cylinder 168 usefulness that are located at plunger rod 150 far-ends are threaded into plunger 130 and screw so that engaged closely.The injector is inserted into entry needle in the required human body such as blood vessel with traditional venipuncture technology then.On this point of program, plunger rod 150 and plunger 130 are in the static engagement state.As shown in figure 10, female thread of plunger 130 143 and the slidably pin thread engagement of cylinder 168, but plunger rod front end 164 contact with the inner plane or the inner concave of plunger 130, therefore to exert pressure on plunger 130.
When the operator when on the direction of far-end, being applied to a less pressure on the plunger rod 150, as shown in figure 11, distortion on the circumference will take place to be listed in down plunger: the convex surface 132 of plunger 130 will be to a distance of remote extension " a ", and distal loop 140, proximal loop 141 and adapter ring 142 will be pulled to inboard distance by elastic pulling force, be respectively " b ", " c " and " d ".Can see that on scheming distance " a " is wherein maximum, next be distance " b ", " c " and " d ".The distortion of this of plunger on circumference will make the gas of front discharge in syringe cylinder, is about to gas and extracts out in syringe.When unclamping the pressure that is applied on the plunger rod 150, plunger 130 turns back to its static position, thereby causes a vacuum and extract body fluid on one's body out from patient in cylindrical shell 120, and this body fluid can indicate entry needle to enter desired area, and injection can begin.So the operator is applied to pressure on the plunger rod 150 once more, the result causes on plunger 130 and the top identical circumferential deformation that illustrates with regard to the suction syringe.Consult proximal loop 141, distal loop 140 and adapter ring 142 on the figure, obviously, the power that these rings act on cylindrical shell 120 medial walls 121 now is reduced, and this reduces with circumferential deformation is caused distance " b ", " c " and " d " are directly proportional.As a result, plunger just can more easily move in cylindrical shell liquid can be injected in the injection site easily.Plunger blocks easily in cylindrical shell when the prolonged storage of syringe of prefilled, power on the interface between plunger and the cylindrical shell medial wall makes both be difficult to separate in the axial direction, at this moment above-mentioned advantage is more obvious, because in this embodiment of the present invention, the power that is applied on the plunger can pull to the inboard with distal loop, proximal loop and adapter ring, thereby can significantly reduce the power on the interface between plunger and the cylindrical shell medial wall.
Have that usually the syringe of the prior art of similar structure is shown in Figure 19 and 20 to the present invention, wherein corresponding parts add left-falling stroke (') with identical label and represent.
Though also have outer convex surface 132 ', plunger 130 ' in do not have inner concave 134 ', promptly plunger 130 ' inner face be flat.Plunger rod front end 164 ' do not exist replaces the planar end surface of its plunger rod that just is connected with the non-convex surface of inboard.When the syringe of operation prior art, by plunger rod 150 ' by plunger rod front end 164 ' be applied to plunger 130 ' on power can not cause ring 140 ', 141 ' and 142 ' dwindling on circumference, therefore can not make and finish the required injection force of injection and obtain reducing.The syringe of shown prior art also lacks the ability from suction because power is applied to plunger rod 150 ' on the time, plunger 130 ' convex surface 132 ' and indeformable, and when unclamping this power, this convex surface can not obtain its profile when static state again.
Consulting Figure 21,22,23,24 and 26 now, shown in it is 210 syringe according to the label third embodiment of the present invention, total, and this syringe has:
A cylindrical shell 220 has 221, one terminations, medial wall to become the tip 222 of band tapering and has the far-end of a through hole 223 and the near-end 224 that termination becomes finger-like bead 226 on it;
A plunger 230 that is located at slidably in the cylindrical shell 220;
One has semicircular pillar stopper rod front end face 282 at its far-end and has the plunger rod 280 of bead 284 and button 286 at its near-end, and said plunger rod is received within the said plunger application cylinder 250.
Consult Figure 22,25,26 and 27, plunger 230 is placed on the near-end 224 in the syringe cylinder slidably.When plunger 230 during in this position, the near-end of syringe cylinder is placed on the flat surface and allows the vertical points upwards of cylindrical shell itself, loading line just can not disturbed by plunger 230 like this.Be injected into required liquid such as medicament or diagnosis development medium in the syringe cylinder by the hole 223 on the band tapering tip 222 then and seal.Introduce in the syringe cylinder liquid can with sterilization technology in advance in batch sterilization be injected in the syringe cylinder then or on this link with the syringe sterilization of autoclaving steamer or other devices with prefilled.After filling process finishes and syringe is sealed, just injector package can be stored, at this moment plunger application cylinder and plunger rod are all also not and the syringe cylinder joint.
Also having an alternative perfusion program in addition is the tip 222 of band tapering is sealed and from the near-end perfusion medicament of cylindrical shell 220, plunger 230 to be inserted in the cylindrical shell 220 after being full of syringe 210 again.Plunger 230 and sealing device are used for remaining on liquid in the syringe cylinder and change its internal liquid volume when injecting to patient subsequently with syringe pump still making the inner sealing that keeps simultaneously.As seeing best from Figure 22 and 25, just as an inverted cup, it has plunger 230 at its relaxed state:
The outer convex surface 232 of a far-end, this outer convex surface become the interface that contacts with liquid in the syringe cylinder 220;
The inner face 234 of a near-end;
With 232 lateral walls that are connected 236, far-end outside;
The medial wall 238 that is connected with the medial surface 234 of near-end; And
On cup-shaped plunger 230, form the foundation ring 239 of a circular hole.
The lateral wall of plunger 230 has distal loop 240, proximal loop 241 and adapter ring 242, these ring elastically deformables are also all radially outwards given prominence to from lateral wall 236, and have an also bigger minimum diameter of maximum gauge than cylindrical shell 220 active sections when connecting together with plunger 230.These rings constitute sealing but engage with the medial wall 221 of cylindrical shell 220 slidably.
The medial wall 238 of plunger 230 have female thread 243 in case admit plunger application cylinder 250 and with its pin thread 270 engagements.Before giving patient in suction and with liquid infusion, plunger application cylinder 250 should be screwed into fully and make screw thread 243 and screw thread 270 engagements in the plunger 230.
Consult Figure 26, plunger rod 280 is inserted into makes 284 of beads in the plunger application cylinder 250, promptly just crossed the handle 262 of plunger application cylinder 250 in the inboard of plunger application cylinder 250.The arresting stop that the button 286 of plunger rod 280 and bead 284 are moved in plunger application cylinder 250 as restriction plunger rod 280.The distance X distance (can be described as advance distance) that the permission plunger rod controlled as the bead 284 of arresting stop and button 286 moves in the plunger application cylinder of serving as reasons.The vertical section of the syringe that assembles shown in Figure 26 has shown each parts of the syringe that assembles, wherein:
X is the distance between bead 284 and the button 286;
Y is the total length of the plunger rod 280 of measurement between plunger rod front end 282 and button 286;
Z is the function portion of syringe cylinder 220 or the total length of operate portions; And
W is the total length of plunger application cylinder 250 and plunger 230.
Show in Figure 28 that as shown in figure 26 and further plunger rod is on its home position, promptly the plunger rod front end does not arrive the inner face 234 of plunger 230, power is not applied thereon yet.Bead 284 contacts with the handle 262 of plunger application cylinder 250 on this home position.
At the combinations of syringe part shown in Figure 27 and 29 is to be in state on its extended position when plunger rod 280.This moment, button 262 was pulled on the handle 262 and the plunger rod front end is applied to power on the inner face 234 of plunger 230.This power is out of shape plunger 230 on circumference: plunger 230 is an elongation distance " a " outwards, and distal loop 240, proximal loop 241 and adapter ring are pulled to inboard distance by elastic pulling force, are respectively " b ", " c " and " d ".As shown in the figure, " a " is wherein maximum, next is distance " b ", " c " and " d ".The distortion of this of plunger on circumference will make the gas of front discharge in syringe leads to, and is about to gas and extracts out in syringe.When unclamping the pressure that is applied on the plunger rod 250, plunger 230 turns back to its static position, thereby causes a vacuum and extract body fluid on one's body out from patient in cylindrical shell 220, and this body fluid can indicate entry needle to enter desired area, and injection can begin.So the operator is applied to pressure on the plunger rod 280 once more, the result causes on plunger 230 and the top identical circumferential deformation that illustrates with regard to the suction syringe.Consult proximal loop 241, distal loop 240 and adapter ring 242 on the figure, obviously, the power that these rings act on cylindrical shell 220 medial walls 221 now is reduced, and this reduces with circumferential deformation is caused distance " b ", " c " and " d " are directly proportional.As a result, plunger just can more easily move in cylindrical shell liquid can be injected in the injection site easily.Plunger blocks easily in cylindrical shell when the prolonged storage of syringe of prefilled, power on the interface between plunger and the cylindrical shell medial wall makes both be difficult to separate in the axial direction, at this moment above-mentioned advantage is more obvious, because in this embodiment of the present invention, the power that is applied on the plunger can pull to the inboard with distal loop, proximal loop and adapter ring, thereby can significantly reduce the power on the interface between plunger and the cylindrical shell medial wall.
Once did overtesting, found out the most effective length of X, Y, Z and W and the ratio between them, can make the combinations of syringe part that the typical case uses in the prefilled syringe so that be used for being configured in.Typical scope is shown below:
Length: X: from 0.010 to 0.750 inch (0.254 to 19.1mm)
Y: from 2.000 to 6.000 inches (50.8 to 152.4mm)
Z: from 6.000 to 10.000 inches (152.4 to 254mm)
W: from 1.990 to 5.990 inches (50.5 to 152.2mm)
Their ratio is as follows:
X: Y from 0.375 to 0.002
X: Z from 0.125 to 0.001
Y: Z from 1.000 to 0.200
W: X from 2.650 to 599
W: Y from 0.332 to 2.990
W: Z from 0.199 to 0.998
The release length of the plunger rod 280 that the ratio of Y is limited by X has a significant impact the power that plunger 230 is split from syringe cylinder medial wall 221.
Present embodiment is following to be operated.
Plunger application cylinder 250 usefulness that fit together with plunger rod 280 in advance are threaded into female thread 243 is meshed with pin thread 270 fully.Plunger rod 280 in this is in its home position or static position, this position is in plunger application cylinder 250, bead 284 is resisted against on the handle 262 of plunger application cylinder 250 at that time, and plunger rod front end 282 also is not applied to pressure on the medial surface 234 of plunger 230.With hypodermic needle by on the tip 222 that is pressed in syringe cylinder 220.The injector is inserted into entry needle in the required human body such as blood vessel with traditional venipuncture technology then.The injector then is applied to pressure on the button 286 of plunger rod 280, and button 286 is shifted onto on the handle 262 that is pressed on plunger application cylinder 250.At this moment, the front end of plunger rod 280 will be oppressed on the inner face of plunger 230 plunger is out of shape on circumference.The convex surface 230 of plunger 230 will be to a distance of remote extension " a ", and distal loop 240, proximal loop 241 and adapter ring will be pulled to inboard distance by elastic pulling force, be respectively " b ", " c " and " d ".The distortion of this of plunger on circumference will make the gas of front discharge in syringe cylinder, is about to gas and extracts out in syringe.The power that is applied on syringe cylinder 220 medial walls 221 by plunger 230 simultaneously just significantly reduces, and causes the injection process after suction finishes to carry out easily.When unclamping the pressure that is applied on the plunger rod 280, plunger 230 is got back to its original profile, thereby causes a vacuum and extract body fluid on one's body out from patient in syringe cylinder 220, and this body fluid can indicate entry needle to enter desired area, and injection can begin.If do not extract body fluid out, the injection site must change so, and aspiration procedure just must repeat.After obtaining desired area like this, the injector just can, be applied to pressure on plunger rod 280 and the plunger application cylinder 250 with liquid infusion in this position for this reason.This pressure causes on plunger 230 and the top identical circumferential deformation that illustrates with regard to the suction syringe.Consult proximal loop 241, distal loop 240 and adapter ring 242 on the figure, obviously, the power that these rings act on cylindrical shell 220 medial walls 221 now is reduced, and this reduces with circumferential deformation is caused distance " b ", " c " and " d " are directly proportional.As a result, plunger just can more easily move in cylindrical shell liquid can be injected in the injection site easily.Plunger blocks easily in cylindrical shell when the prolonged storage of syringe of prefilled, and the power on the interface between plunger and the cylindrical shell medial wall makes them be difficult to separate in the axial direction.At this moment above-mentioned advantage is more obvious, because in this embodiment of the present invention, the power that is applied on the plunger can pull to the inboard with distal loop, proximal loop and adapter ring, thereby can significantly reduce the power on the interface between plunger and the cylindrical shell medial wall.
What should affirm is, above-mentioned these more excellent embodiment of syringe of the present invention had an ideal syringe suction and inject aspect two most of attributes that should have, that is, simple structure, producing cost are low; Simple to operate; Can be with a manual operating; Each syringe or syringe can both carry out repeatedly from suction action; Can be before suction action in beginning, or in injection any one time in required a succession of action the air that is absorbed in is got rid of in syringe or syringe, and can not need therefore in operating sequence any point cancellation from suction action or make from suction action and become and can not operate.
Claims (25)
1, a kind of syringe with a cylindrical shell, a plunger and a plunger rod, said plunger rod can move and impel the plunger distortion, thereby reduce the friction between cylindrical shell inboard and plunger, still can remain on the sealing between cylindrical shell inboard and the plunger simultaneously.
2, according to the syringe of claim 1, it is characterized by, said plunger is arranged to owing to the action of plunger rod distortion vertically, thereby reduces the friction between cylindrical shell inboard and plunger.
3, according to the syringe of claim 2, it is characterized by, plunger is essentially cup-shaped, and its near-end opens wide, and its distal portion is arranged to owing to the action of plunger rod distortion vertically.
4, according to the syringe of claim 2 or 3, it is characterized by, have a stopper that remains in the plunger cavity, stopper is provided with female thread, and plunger rod is provided with pin thread on a part of its far-end, can cooperate with the female thread on the stopper.
5, according to the syringe of claim 4, it is characterized by: it is outer and contact with the inner surface of plunger that plunger rod has parts to reach its threaded part, when plunger rod when being threaded in the stopper, the extension on this plunger rod is used for making the plunger distortion when plunger rod continues to be screwed in the stopper.
6, according to the syringe of claim 2 or 3, it is characterized by, plunger rod has a rod member and one and the connecting piece of plunger, and rod member can slide with respect to connecting piece in the axial direction.
7, according to the syringe of claim 6, it is characterized by, is one to be looped around the pipe fitting of rod member far-end with the connecting piece of plunger.
8, according to the syringe of claim 6 or 7, it is characterized by, the motion of rod member is limited by two stop parts that are located at the rod member far-end.
9, according to each syringe in the claim 6 to 8, it is characterized by, rod member can be with respect to moving between the two positions with the connecting piece of plunger, the far-end that position is a rod member reaches outside the far-end with the plunger connecting piece, and another position is that the far-end of rod member does not reach outside the far-end with the plunger connecting piece.
10, according to each syringe in the claim 6 to 9, it is characterized by, plunger is provided with screw thread in inside, is provided at an outer portion with screw thread with the plunger connecting piece, and these two screw-threaded engagement make with the plunger connecting piece and remain in the plunger.
11, according to the syringe of claim 2 or 3, it is characterized by, plunger rod has one and is essentially piped outer part, and this outer part surrounds one and is essentially shaft-like internals, and internals can be slided relatively mutually with outer part.
12, according to the syringe of claim 11, it is characterized by, internals are limited by two stop parts with respect to the slip of outer part.
13, according to the syringe of claim 11 or 12, it is characterized by, internals can be with respect to outer part and move between the two positions, and the far-end that position is internals reaches outside the far-end of outer part, and another position is that the far-end of internals does not reach outside the far-end of outer part.
14, according to each syringe in the claim 11 to 13, it is characterized by, plunger inside be provided with screw thread and outside the far-end of part be provided at an outer portion with screw thread, these two screw-threaded engagement remain in the plunger outer part.
15, according to each the syringe in the above claim, it is characterized by, plunger has a distal loop, an adapter ring and a proximal loop on its periphery, the plunger distortion is drawn back from the cylindrical shell medial wall up to major general's distal loop, will have proximal loop to keep contacting with cylinder inner surface simultaneously at least.
16, a kind of syringe that is designed to be full of in advance and stores and can be used to immediately inject, this syringe has:
(a) cylindrical shell, its inner surface forms a cylinder bodily form chamber that can be used to keep injection, and its far-end becomes a tip that can be used to adorn the band tapering of entry needle, and its near-end is used for admitting a plunger;
(b) cup-shaped plunger is contained in the said cylindrical shell slidably, and the position is near the near-end of cylindrical shell, constitutes sealing between it and cylinder inner surface, and said plunger has:
The convex surface of (1) far-end becomes the interface that contacts with injection in the cylindrical shell;
(2) proximal end faces;
There are distal loop, proximal loop and adapter ring in (3) lateral walls that are connected with the far-end convex surface on it, these rings are radially outwards given prominence to and constituted a slidably sealing with cylinder inner surface;
(4) medial walls;
(5) foundation rings, it forms the cavity of a receive posts stoppering with the medial wall;
(c) one has far-end and near-end and the position inflexible plunger stopper in said cavity, and this plunger stopper has: the medial wall of a band female thread is so that the pin thread on admittance and the joggle post stopper rod; Position is in the bead of near-end, and its diameter is greater than the interior diameter of plunger foundation ring, and therefore said plunger stopper can be clamped in the said cavity securely; And
(d) one has the plunger rod that far-end and near-end can be used to mesh plunger, and this plunger rod has:
(1) shoulder that is located at the plunger rod far-end, when being inserted into plunger rod in the plunger, this shoulder contacts with the foundation ring of plunger so that limit the prolongation of plunger;
(2) cervical regions with plunger rod front end adjacency, which is provided with pin thread in case with the plunger stopper on the female thread engagement; And
(3) positions outstanding forward plunger rod front ends on the direction of plunger rod far-end at plunger, its diameter are obviously less than the diameter of plunger, and are designed to contact with the near-end medial surface of plunger central part.
17, a kind ofly be designed to prefilled and storage and can be used for the syringe injected immediately, this syringe has:
(a) cylindrical shell, its inner surface forms a cylinder bodily form chamber that can be used to keep injection, and its far-end becomes a tip that can be used to adorn the band tapering of entry needle, and its near-end is used for admitting a plunger;
(b) cup-shaped plunger is contained in the said cylindrical shell slidably, and the position is near the near-end of cylindrical shell, constitutes sealing between it and cylinder inner surface, and said plunger has:
The convex surface of (1) far-end becomes the interface that contacts with injection in the cylindrical shell;
The plane or the concave surface of (2) parallel with the far-end convex surface basically near-ends;
There are distal loop, proximal loop and adapter ring in (3) lateral walls that are connected with the far-end convex surface on it, these rings are radially outwards given prominence to and constituted a slidably sealing with cylinder inner surface;
(4) medial walls that are provided with female thread;
(5) foundation rings, it forms a circular hole with the medial wall on the cup-shaped plunger, and plunger rod can insert so that engage by this hole; And
(c) one has far-end and near-end and is used for plunger rod with plug engages, and this plunger rod has:
(1) position is at the plunger rod front end face of plunger rod far-end, has on the plunger direction the semicircle convex surface of projection forward, and its diameter is obviously less than the diameter of plunger, and is designed to contact with the plane or the concave surface of plunger central part near-end inboard;
(2) cervical regions with plunger rod front end face adjacency, design is used for admitting a slidably cylinder;
(3) the slidably cylinders of position around cervical region, this cylinder has a medial wall and a lateral wall, the medial wall forms a cylinder, its diameter less than the diameter of plunger rod front end face so that prevent that slidably cylinder skids off from cervical region, the lateral wall is provided with pin thread and can meshes with the female thread on the plunger, so that can be used to operating syringe when being inserted into plunger rod in the plunger.
18, a kind ofly be designed to prefilled and storage and can be used for the syringe injected immediately, this syringe has:
(a) cylindrical shell, its inner surface become a cylindrical shape chamber that can be used to keep injection; Its far-end becomes a tip that can be used to adorn the band tapering of entry needle; Its near-end is used for admitting a plunger;
(b) cup-shaped plunger is contained in the said cylindrical shell slidably, and the position is near the near-end of cylindrical shell, constitutes sealing between it and cylinder inner surface, and said plunger has:
The convex surface of (1) far-end becomes the interface that contacts with injection in the cylindrical shell;
(2) proximal end faces;
(3) lateral walls that are connected with the far-end convex surface have on it: distal loop, proximal loop and adapter ring, these rings are radially outwards given prominence to and are constituted a slidably sealing with cylinder inner surface;
(4) medial walls that are provided with female thread thereon; And
(5) foundation rings, it forms one with the medial wall and can insert so that the circular hole that engages for the plunger application cylinder in the cup-shaped plunger;
(c) one has far-end and near-end, is used for plunger application cylinder with plug engages, and this application cylinder has:
(1) be located at far-end be used for plunger on the pin thread of female thread engagement; And
(2) handles that are located at near-end; And
(d) one has far-end and near-end and is contained in plunger rod in the said plunger application cylinder, and this plunger rod has:
(1) one is located at far-end and has on the plunger direction the semicircle front end face of projection forward, and its diameter is obviously less than the diameter of plunger, so that add on the proximal end face that is pressed in plunger when being applied to pressure on the plunger rod;
(2) one are located at near-end and the position button outside the plunger application cylinder, are used as first arresting stop of plunger rod and so that be used for limiting moving of plunger rod it are extend in the proximal end face of plunger; And
(3) one also are provided in a side of near-end but stand away with button and the bead of position in the plunger application cylinder, are used as second arresting stop of plunger rod so that be used for limiting plunger rod moving on the direction of plunger application cylinder near-end;
Said first arresting stop and second arresting stop are designed to plunger rod mobile in the plunger application cylinder is limited in one by in the predetermined length that distance limited between first and second arresting stops.
19, according to each syringe in the above claim, it is characterized by, said syringe cylinder is to be made by a kind of not material of saturating noble gas, and this material can be selected for use from the cohort that contains glass, polyethylene, polypropylene, polystyrene, acrylate copolymer and methacrylate polymer.
20, according to each syringe in the above claim, it is characterized by, said plunger is made by a kind of compressible elastomeric material.
21, a kind of syringe that each limited from above claim is injected method to patient with a kind of liquid medium, this method comprises the following steps: plunger rod is joined on the plunger, hypodermic needle is installed on the syringe, entry needle is inserted in patient's desired area, a small pressure is applied to makes plunger distortion on the plunger rod and get rid of any gas, unclamp pressure then so that in syringe, cause partial vacuum, thereby from patient body, body fluid is drawn in the cylindrical shell.
22, according to the method for claim 21, it is characterized by, said liquid medium is a kind of medicament composition.
23, according to the method for claim 21, it is characterized by, said liquid medium is a kind of biological preparation.
24, according to the method for claim 21, it is characterized by, said liquid medium is a kind of compositions of diagnosing usefulness.
25, according to the method for claim 21, it is characterized by, said liquid medium is a kind of image selecting agent.
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/239,087 US5413563A (en) | 1994-05-06 | 1994-05-06 | Pre-filled syringe having a plunger, plunger insert and plunger rod |
| US08/239,092 | 1994-05-06 | ||
| US08/239,095 | 1994-05-06 | ||
| US08/239,092 US5411488A (en) | 1994-05-06 | 1994-05-06 | Pre-filled syringe and pre-filled cartridge having an improved plunger and plunger rod for reducing syringing force |
| US08/239,095 US5411489A (en) | 1994-05-06 | 1994-05-06 | Pre-filled syringe and pre-filled cartridge having actuating cylinder/plunger rod combination for reducing syringing force |
| US08/239,087 | 1994-05-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1152882A true CN1152882A (en) | 1997-06-25 |
Family
ID=27399201
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN95193831A Pending CN1152882A (en) | 1994-05-06 | 1995-05-01 | Low drag syringe and cartridge |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0758255B1 (en) |
| JP (1) | JP3665646B2 (en) |
| KR (1) | KR970702735A (en) |
| CN (1) | CN1152882A (en) |
| AU (1) | AU2349295A (en) |
| BR (1) | BR9507625A (en) |
| CA (1) | CA2189654A1 (en) |
| DE (1) | DE69527782T2 (en) |
| DK (1) | DK0758255T3 (en) |
| ES (1) | ES2184798T3 (en) |
| FI (1) | FI964451A0 (en) |
| HU (1) | HUT76899A (en) |
| MX (1) | MXPA96005373A (en) |
| NO (1) | NO964669L (en) |
| WO (1) | WO1995030444A1 (en) |
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| US2895773A (en) * | 1956-10-22 | 1959-07-21 | Robert K Mcconnaughey | Variable diameter tensed ring piston |
| US3543755A (en) * | 1967-11-09 | 1970-12-01 | John Delbert Kessel | Ampule for hypodermic syringes |
| US3834387A (en) * | 1972-08-10 | 1974-09-10 | Sherwood Medical Ind Inc | Breech loaded syringe with deformable piston |
| US3939833A (en) * | 1975-01-15 | 1976-02-24 | Astra Pharmaceutical Products Inc. | Piston construction for syringes |
-
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- 1995-05-01 MX MXPA96005373A patent/MXPA96005373A/en unknown
- 1995-05-01 WO PCT/GB1995/000982 patent/WO1995030444A1/en active IP Right Grant
- 1995-05-01 AU AU23492/95A patent/AU2349295A/en not_active Abandoned
- 1995-05-01 EP EP95917414A patent/EP0758255B1/en not_active Expired - Lifetime
- 1995-05-01 HU HU9603073A patent/HUT76899A/en unknown
- 1995-05-01 DK DK95917414T patent/DK0758255T3/en active
- 1995-05-01 DE DE69527782T patent/DE69527782T2/en not_active Expired - Lifetime
- 1995-05-01 KR KR1019960706273A patent/KR970702735A/en not_active Application Discontinuation
- 1995-05-01 BR BR9507625A patent/BR9507625A/en not_active Application Discontinuation
- 1995-05-01 ES ES95917414T patent/ES2184798T3/en not_active Expired - Lifetime
- 1995-05-01 CA CA002189654A patent/CA2189654A1/en not_active Abandoned
- 1995-05-01 CN CN95193831A patent/CN1152882A/en active Pending
- 1995-05-01 JP JP52875795A patent/JP3665646B2/en not_active Expired - Lifetime
-
1996
- 1996-11-05 NO NO964669A patent/NO964669L/en unknown
- 1996-11-05 FI FI964451A patent/FI964451A0/en not_active Application Discontinuation
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| CN113226408A (en) * | 2018-12-27 | 2021-08-06 | 株式会社大赛璐 | Needleless injector |
| CN113226408B (en) * | 2018-12-27 | 2023-04-07 | 株式会社大赛璐 | Needleless injector |
| CN115335099A (en) * | 2020-03-11 | 2022-11-11 | 贝克顿迪金森法国公司 | Plunger rod and syringe comprising the same |
| WO2023216963A1 (en) * | 2022-05-11 | 2023-11-16 | 苏州嘉树医疗科技有限公司 | Boosting mechanism for liquid container |
Also Published As
| Publication number | Publication date |
|---|---|
| FI964451A (en) | 1996-11-05 |
| NO964669D0 (en) | 1996-11-05 |
| JP3665646B2 (en) | 2005-06-29 |
| MXPA96005373A (en) | 2005-05-25 |
| AU2349295A (en) | 1995-11-29 |
| KR970702735A (en) | 1997-06-10 |
| DK0758255T3 (en) | 2002-12-16 |
| DE69527782T2 (en) | 2003-05-15 |
| HUT76899A (en) | 1997-12-29 |
| WO1995030444A1 (en) | 1995-11-16 |
| BR9507625A (en) | 1997-09-23 |
| JPH09512727A (en) | 1997-12-22 |
| ES2184798T3 (en) | 2003-04-16 |
| HU9603073D0 (en) | 1997-01-28 |
| EP0758255A1 (en) | 1997-02-19 |
| EP0758255B1 (en) | 2002-08-14 |
| DE69527782D1 (en) | 2002-09-19 |
| NO964669L (en) | 1997-01-03 |
| FI964451A0 (en) | 1996-11-05 |
| CA2189654A1 (en) | 1995-11-16 |
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