CN115266186B - Intelligent pathological section machine refrigerating plant - Google Patents

Intelligent pathological section machine refrigerating plant Download PDF

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Publication number
CN115266186B
CN115266186B CN202210643119.5A CN202210643119A CN115266186B CN 115266186 B CN115266186 B CN 115266186B CN 202210643119 A CN202210643119 A CN 202210643119A CN 115266186 B CN115266186 B CN 115266186B
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China
Prior art keywords
freezing
device shell
section
driving motor
cavity
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CN202210643119.5A
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Chinese (zh)
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CN115266186A (en
Inventor
陈源
朱鑑贤
沈志能
黄海锋
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Guangzhou Wexis Biotech Ltd
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Guangzhou Wexis Biotech Ltd
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Priority to CN202210643119.5A priority Critical patent/CN115266186B/en
Publication of CN115266186A publication Critical patent/CN115266186A/en
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/02Devices for withdrawing samples
    • G01N1/04Devices for withdrawing samples in the solid state, e.g. by cutting
    • G01N1/06Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25BREFRIGERATION MACHINES, PLANTS OR SYSTEMS; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS
    • F25B21/00Machines, plants or systems, using electric or magnetic effects
    • F25B21/02Machines, plants or systems, using electric or magnetic effects using Peltier effect; using Nernst-Ettinghausen effect
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25BREFRIGERATION MACHINES, PLANTS OR SYSTEMS; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS
    • F25B39/00Evaporators; Condensers
    • F25B39/04Condensers
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25BREFRIGERATION MACHINES, PLANTS OR SYSTEMS; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS
    • F25B41/00Fluid-circulation arrangements
    • F25B41/30Expansion means; Dispositions thereof
    • F25B41/37Capillary tubes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/28Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/28Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/42Low-temperature sample treatment, e.g. cryofixation

Abstract

The invention relates to the technical field of medical instruments and discloses an intelligent pathological section machine freezing device which comprises a device shell, wherein a freezing section cavity and a refrigerating cavity are arranged in the device shell, the freezing section cavity is positioned on one side of the upper end in the device shell, the refrigerating cavity is positioned on the lower end in the device shell, a compressor is installed at the middle position of the lower end in the refrigerating cavity through a fixing frame, a high-pressure exhaust pipe is installed at the output end of the compressor, a condenser is installed at one end of the outer part of the high-pressure exhaust pipe, a capillary tube is installed at the output end of the condenser, an evaporation refrigerator is installed at one side of the upper end in the freezing section cavity, a section box is installed at one side of the lower end in the freezing section cavity, a semiconductor refrigerator is installed at the lower end of the section box, and pathological materials are kept fresh continuously by cooling the inside of the freezing section cavity and refrigerating the section box in the freezing section cavity.

Description

Intelligent pathological section machine refrigerating plant
Technical Field
The invention relates to the technical field of medical instruments, in particular to an intelligent freezing device of a pathological section machine.
Background
In animal histology, pathology, biology, etc. disciplines and clinical practice, physicians need to obtain tissue sections that can be used for observation in a short time. The instrument for freezing the microtome can quickly make tissue slices for observation by enabling tissues to reach certain hardness at low temperature. The freezing microtome consists of a slicing device and a refrigerating system. The complete freezing and slicing system is generally composed of a main machine (a freezing box, a sample head, a quick freezing table and other devices), a knife rest and a blade. The section range of the freezing microtome is 1-500 μm.
For example, chinese granted patent publication CN211527873U (a pathological microtome): the novel kitchen knife comprises a base, the side surface bottom of base is provided with the mouth that charges, the spring fixed orifices has been seted up to the one end that the mouth that charges was kept away from to the side surface of base, the upper surface rear end fixed mounting of base has the casing, the upper surface front end of base is close to the fixed position of casing and has the cutter mounting bracket, the front surface joint of base has the detachable garbage collection device, the side surface one end fixed mounting of casing has little hand wheel, the side surface other end fixed mounting of casing has big hand wheel, the front surface inclined plane position embedding of casing is provided with liquid crystal display, the last fixed surface of casing installs the freezer. The pathological section cutter can improve the cutting chip cleaning efficiency of the pathological section cutter, avoids the direct contact of workers with the pathological tissue, and meanwhile, can directly put the sliced tissue into the freezing chamber for refrigeration, saves the material taking time and is convenient to use.
Although the pathological materials after being sliced are refrigerated by the freezing chamber in the prior art, the pathological materials are not provided with a heat insulation structure in the slicing process and the process of moving to the freezing chamber, and the pathological tissues are possibly deteriorated under the influence of external temperature, so that the subsequent inspection operation is influenced, and the intelligent freezing device of the pathological microtome is provided.
Disclosure of Invention
Technical problem to be solved
Aiming at the defects of the prior art, the invention provides a freezing device of an intelligent pathological section machine, which can continuously keep the freshness of pathological materials by refrigerating a freezing section cavity and a section box so as to solve the problems in the background technology.
(II) technical scheme
In order to achieve the purpose, the invention provides the following technical scheme: the utility model provides an intelligent pathological section machine refrigerating plant, includes the device shell, the inside of device shell is provided with freezing section chamber and refrigeration chamber, freezing section chamber is located one side of the inside upper end of device shell, the refrigeration chamber is located the inside lower extreme of device shell, the compressor is installed through the mount to the intermediate position department of the inside lower extreme in refrigeration chamber, high-pressure vent pipe is installed to the output of compressor, the condenser is installed to the outside one end of high-pressure vent pipe, the capillary is installed to the output of condenser, the evaporation refrigerator is installed to one side of freezing section intracavity portion upper end, and the input of evaporation refrigerator passes through the pipe connection with the capillary, slice box is installed to one side of freezing section intracavity portion lower extreme, semiconductor cooler is installed to slice box's lower extreme, and slice box and semiconductor cooler's refrigeration end fixed connection.
Preferably, the lower extreme of semiconductor cooler runs through and extends to the inside in refrigeration chamber, radiating fin is installed to semiconductor cooler's lower extreme, and radiating fin and semiconductor cooler fixed connection, one side that the device shell outside is close to radiating fin is provided with the second air exit, and second air exit and device shell integrated into one piece, the internally mounted of second air exit has the second dust screen, and second dust screen and second air exit fixed connection.
Preferably, a second driving motor is installed between the outer portion of the radiating fin and the second dust screen through a second motor fixing frame, a second fan blade is installed at the output end of the second driving motor, and the second fan blade is connected with the output end of the second driving motor through a coupler.
Preferably, a low-pressure air return pipe is installed at the input end of the compressor and is fixed to the compressor in a sealing mode, the input end of the low-pressure air return pipe is connected with the output end of the evaporation refrigerator through a pipeline, a first air exhaust opening is formed in one side, close to the condenser, of the outer portion of the device shell, and the first air exhaust opening and the device shell are integrally formed.
Preferably, the internally mounted of first exhaust opening has first dust screen, and first dust screen and first exhaust opening fixed connection, one side that the refrigeration intracavity portion is close to first dust screen installs first driving motor through first motor mount, first flabellum is installed to first driving motor's output, and first flabellum passes through the coupling joint with first driving motor's output.
Preferably, one side of the inside upper end of device shell is provided with interior spout, and interior spout and device shell integrated into one piece, the internally mounted of interior spout has the baffle, and baffle and interior spout sliding connection, the fixed block is installed for one side of baffle lower extreme to freezing section intracavity wall, and fixed block and device shell fixed connection, the controller is installed to one side of the outside upper end of device shell.
Preferably, electric telescopic handle is installed to the upper end of fixed block, and electric telescopic handle's input and the output electric connection of controller, the inserted bar is installed for one side of baffle lower extreme to the device shell outside, and the inserted bar runs through the baffle and extends to the inside in freezing section chamber, the inside one side of inserted bar is provided with the jack, and electric telescopic handle and jack looks adaptation.
Preferably, the device housing is provided with a through window, the through window being disposed proximate to the cryo-slicing chamber.
Preferably, an OCT embedding device is further disposed in the frozen section cavity, and the OCT embedding device is used for smearing an OCT embedding medium on the tissue to be sectioned;
the OCT embedding device comprises a U-shaped plate, two first sliding rods are arranged in an opening of the U-shaped plate at intervals, the two first sliding rods penetrate through a first sliding block and are arranged, two second sliding rods are further arranged on the first sliding block in a penetrating mode, the two second sliding rods are perpendicular to the two first sliding rods, the U-shaped plate is arranged on the inner bottom surface of a frozen section cavity, a mounting frame is arranged at one end of each of the two second sliding rods, an OCT spray gun is detachably arranged in the mounting frame, a mounting block is arranged at the other end of each of the two second sliding rods and is rotatably arranged on the upper top surface of the second sliding block, the second sliding blocks are arranged in the sliding rails in a sliding mode, the sliding rails are arranged on the upper surface of a rotary table, a third driving motor is arranged on the lower surface of the rotary table, and an output shaft of the third driving motor is connected with the circle center of the rotary table;
the inner wall of the sliding rail is provided with an electric push rod, one end of the electric push rod is arranged at one end of the sliding rail, the other end of the electric push rod is connected with the second sliding block, and the electric push rod is used for adjusting the distance between the second sliding block and the circle center of the rotary table.
Preferably, a gravity sensor is arranged between the semiconductor refrigerator and the slicing box, the gravity sensor is electrically connected with a data processing module, the data analysis processing module is electrically connected with the drying device, the gravity sensor is used for detecting the weight change of the slicing box, and the data processing module is used for collecting the data change of the gravity sensor so as to start the drying device.
Preferably, the drying device comprises a U-shaped frame, two ends of the U-shaped frame are arranged on the top surface in the frozen section cavity, an opening of the U-shaped frame faces the evaporation refrigerator, two gears are arranged on the inner bottom surface of the U-shaped frame at intervals, the gears are rotatably connected with the U-shaped frame, one of the gears is connected with an output shaft of a fourth driving motor through an axis, the two gears are meshed with each other, the fourth driving motor is used for driving the gears to rotate, first connecting rods are eccentrically arranged on the surfaces of the two gears, one ends of the two first connecting rods, which are far away from the gears, are arranged at two ends of a second connecting rod, the first connecting rods are rotatably connected with the gears, and the first connecting rods are hinged with the second connecting rods;
a third sliding block is arranged in the middle of the second connecting rod, the third sliding block is arranged in a drainage sliding groove in a sliding mode, and the drainage sliding groove is formed in the inner bottom surface of the U-shaped frame;
the bottom surface in the U-shaped frame is also provided with a sponge mounting table, a clamping groove is formed in the sponge mounting table and used for clamping absorbent cotton, a drainage groove is formed in the bottom surface in the clamping groove, and one end of the drainage groove penetrates through the side wall of the clamping groove and is communicated with the outside of the mounting table;
the fourth driving motor is electrically connected with the data processing module.
Preferably, water drainage tank and water drainage tank union coupling, water drainage tank sets up U type frame is kept away from evaporation refrigerator's one side, water drainage tank's one end is provided with the piston rod, the piston rod is kept away from water drainage tank's one end is connected the third slider, the cooperation of third slider the second connecting rod is used for the drive the piston rod is in slide in the water drainage tank, water drainage tank with be provided with first solenoid valve between the water drainage tank, water drainage tank still is provided with the second solenoid valve, the second solenoid valve is kept away from water drainage tank's one end union coupling has the shower nozzle, the shower nozzle output sets up compressor one side.
(III) advantageous effects
Compared with the prior art, the invention provides an intelligent pathological microtome freezing device, which has the following beneficial effects:
1. starting the semiconductor refrigerator and the compressor, refrigerating the refrigerating end of the semiconductor refrigerator, so that the slice box keeps low temperature and the pathological material is kept fresh, the compressor sucks a refrigerant in a gaseous state, the refrigerant is compressed into high-temperature and high-pressure steam and then enters the condenser through the high-pressure exhaust pipe, the heat is discharged through the condenser, the steam is condensed into high-pressure liquid, then the high-pressure liquid enters the capillary tube for pressure reduction, the high-pressure liquid enters the evaporation refrigerator from the capillary tube for vaporization and heat absorption, the interior of the frozen slice cavity is cooled, and the pathological material is kept fresh through refrigeration of the frozen slice cavity and the slice box;
2. when the semiconductor refrigerator is used, the heating end of the semiconductor refrigerator generates heat, the heat is transmitted through the radiating fins, the second driving motor is started, the second fan blades at the output end of the second driving motor rotate to generate air flow, the heat outside the radiating fins flows along with the air and is exhausted through the second air outlet, when the compressor is used, the heat outside the condenser generates heat, the first driving motor is started, the first fan blades at the output end of the first driving motor rotate to generate air flow, and the heat outside the condenser is exhausted through the first air outlet under the action of the air flow;
3. start electric telescopic handle through the controller, electric telescopic handle's one end shifts out from the inside jack of inserted bar, cancelled spacing to the inserted bar, the pulling inserted bar makes it break away from the baffle afterwards, with this cancellation spacing to the baffle, will carry out sliced pathology material afterwards and place the upper end at the section box, closed baffle afterwards, insert the inserted bar, it is fixed with the inserted bar to make it insert the jack through controller control electric telescopic handle, make the fixed convenient and fast more of inserted bar through electric telescopic handle, play the effect that prevents section in-process maloperation opening baffle through the controller.
Drawings
FIG. 1 is a perspective view of the overall structure of the present invention;
FIG. 2 is a perspective view of the overall internal structure of the present invention;
FIG. 3 is an enlarged view of the area A of FIG. 2 according to the present invention;
FIG. 4 is a perspective view of the heat sink fins and a second driving motor according to the present invention;
FIG. 5 is a perspective view of the structure of the electric telescopic rod and the inserting rod of the present invention;
FIG. 6 is a schematic structural diagram of an OCT embedding apparatus according to the invention;
FIG. 7 is a schematic view of the turntable structure of the present invention;
FIG. 8 is a schematic view of the drying apparatus according to the present invention;
FIG. 9 is a schematic view of a sponge mounting table according to the present invention;
FIG. 10 is a schematic view of the structure of the drainage channel of the present invention;
fig. 11 is a schematic view of the drain tank of the present invention.
In the figure: 1. a device housing; 2. a frozen section cavity; 3. a refrigeration cavity; 4. a controller; 5. a window is penetrated; 6. a compressor; 7. a low-pressure air return pipe; 8. a high-pressure exhaust pipe; 9. a condenser; 10. a first drive motor; 11. a first fan blade; 12. a first motor mount; 13. a first exhaust port; 14. a first dust screen; 15. a second air outlet; 16. a second dust screen; 17. a capillary tube; 18. an evaporation refrigerator; 19. an inner chute; 20. a baffle plate; 21. a fixed block; 22. an electric telescopic rod; 23. a rod is inserted; 24. a jack; 25. cutting a sheet box; 26. a semiconductor refrigerator; 27. a heat dissipating fin; 28. a second drive motor; 29. a second fan blade; 30. a second motor mount; 31. a slide rail; 32. a second slider; 33. mounting a block; 34. a turntable; 35. an electric push rod; 36. a U-shaped plate; 37. a first slide bar; 38. a first slider; 39. a second slide bar; 40. a mounting frame; 41. an OCT spray gun; 42. a third drive motor; 43. a U-shaped frame; 44. a drainage chute; 45. a first link; 46. a gear; 47. a second link; 48. a third slider; 49. a sponge mounting table; 50. a water discharge tank; 51. a card slot; 52. a drain tank; 53. a piston rod; 54. a first solenoid valve; 55. a second solenoid valve.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be obtained by a person skilled in the art without making any creative effort based on the embodiments in the present invention, belong to the protection scope of the present invention.
As shown in fig. 1-11, the invention provides a technical solution, an intelligent pathological microtome freezing device, comprising a device housing 1, a freezing section cavity 2 and a refrigerating cavity 3 are arranged inside the device housing 1, the freezing section cavity 2 is positioned at one side of the upper end inside the device housing 1, the refrigerating cavity 3 is positioned at the lower end inside the device housing 1, a compressor 6 is installed at the middle position of the lower end inside the refrigerating cavity 3 through a fixing frame, a high-pressure exhaust pipe 8 is installed at the output end of the compressor 6, a condenser 9 is installed at one end outside the high-pressure exhaust pipe 8, a capillary tube 17 is installed at the output end of the condenser 9, an evaporation refrigerator 18 is installed at one side of the upper end inside the freezing section cavity 2, the input end of the evaporation refrigerator 18 is connected with the capillary tube 17 through a pipeline, a section box 25 is installed at one side of the lower end inside the freezing section cavity 2, semiconductor cooler 26 is installed to the lower extreme of section box 25, and section box 25 and semiconductor cooler 26's refrigeration end fixed connection, start semiconductor cooler 26 and compressor 6, semiconductor cooler 26's refrigeration end refrigerates, thereby make section box 25 keep low temperature, play the fresh-keeping effect to pathological material, compressor 6 inhales the refrigerant with gaseous form, get into condenser 9 through high-pressure blast pipe 8 after compressing into the high-temperature high-pressure steam, discharge the heat through condenser 9, the steam condensation is high-pressure liquid, get into capillary 17 afterwards and step down, it carries out the vaporization heat absorption to get into evaporation refrigerator 18 from capillary 17, cool down with this inside to freezing section chamber 2, make pathological material continuously fresh-keeping through the refrigeration to freezing section chamber 2 and the refrigeration of section box 25.
Further, the lower extreme of semiconductor refrigerator 26 runs through and extends to the inside in refrigeration chamber 3, radiating fin 27 is installed to semiconductor refrigerator 26's lower extreme, and radiating fin 27 and semiconductor refrigerator 26 fixed connection, one side that device shell 1 outside is close to radiating fin 27 is provided with second air exit 15, and second air exit 15 and device shell 1 integrated into one piece, the internally mounted of second air exit 15 has second dust screen 16, and second dust screen 16 and 15 fixed connection of second air exit, second dust screen 16 plays the dustproof effect to second air exit 15.
Further, a second driving motor 28 is installed between the outside of the heat dissipation fin 27 and the second dust screen 16 through a second motor fixing frame 30, a second fan blade 29 is installed at the output end of the second driving motor 28, the second fan blade 29 is connected with the output end of the second driving motor 28 through a coupler, and the second fan blade 29 rotates to generate an air flow to dissipate heat of the heat dissipation fin 27.
Further, a low-pressure air return pipe 7 is installed at the input end of the compressor 6, the low-pressure air return pipe 7 is fixed with the compressor 6 in a sealing mode, the input end of the low-pressure air return pipe 7 is connected with the output end of the evaporation refrigerator 18 through a pipeline, a first air exhaust port 13 is formed in one side, close to the condenser 9, of the outer portion of the device shell 1, and the first air exhaust port 13 and the device shell 1 are integrally formed.
Further, the internally mounted of first exhaust opening 13 has first dust screen 14, and first dust screen 14 and first exhaust opening 13 fixed connection, the inside one side that is close to first dust screen 14 in refrigeration chamber 3 installs first driving motor 10 through first motor mount 12, first flabellum 11 is installed to first driving motor 10's output, and first flabellum 11 passes through the coupling joint with first driving motor 10's output, first flabellum 11 rotates and produces the air current and dispels the heat to condenser 9.
Further, one side of the inner upper end of the device shell 1 is provided with an inner chute 19, the inner chute 19 and the device shell 1 are integrally formed, a baffle 20 is arranged inside the inner chute 19, the baffle 20 is connected with the inner chute 19 in a sliding mode, a fixing block 21 is arranged on the inner wall of the freezing section cavity 2 relative to one side of the lower end of the baffle 20, the fixing block 21 is fixedly connected with the device shell 1, and the controller 4 is arranged on one side of the outer upper end of the device shell 1.
Further, electric telescopic handle 22 is installed to the upper end of fixed block 21, and electric telescopic handle 22's input and controller 4's output electric connection, device shell 1 is outside to install inserted bar 23 for one side of baffle 20 lower extreme, and inserted bar 23 runs through baffle 20 and extends to the inside in frozen section chamber 2, the inside one side of inserted bar 23 is provided with jack 24, and electric telescopic handle 22 and jack 24 looks adaptation, play spacing fixed action to inserted bar 23 through electric telescopic handle 22.
Further, device shell 1 is provided with through window 5, through window 5 is close to the setting of freezing section chamber 2, and through window 5 makes the observation of section work more convenient.
The working principle and the beneficial effects of the embodiment are as follows:
the controller 4 is used for starting the electric telescopic rod 22, one end of the electric telescopic rod 22 is moved out of the inserting hole 24 in the inserting rod 23, the limit of the inserting rod 23 is cancelled, then the inserting rod 23 is pulled to be separated from the baffle plate 20, the limit of the baffle plate 20 is cancelled, then pathological materials needing to be sliced are placed at the upper end of the slicing box 25, then the baffle plate 20 is closed, the inserting rod 23 is inserted, the electric telescopic rod 22 is controlled by the controller 4 to be inserted into the inserting hole 24 to fix the inserting rod 23, the fixing of the inserting rod 23 is more convenient and faster through the electric telescopic rod 22, the controller 4 is used for preventing the baffle plate 20 from being opened by misoperation in the slicing process, the semiconductor refrigerator 26 and the compressor 6 are started, the refrigerating end of the semiconductor refrigerator 26 is used for refrigerating, so that the slicing box 25 is kept at low temperature, the fresh-keeping effect on the pathological materials is achieved, the compressor 6 is used for sucking the refrigerant in a gaseous form, the steam compressed into high-temperature and high-pressure steam enters a condenser 9 through a high-pressure exhaust pipe 8, the heat is discharged through the condenser 9, the steam is condensed into high-pressure liquid, then the high-pressure liquid enters a capillary pipe 17 for pressure reduction, the high-temperature and high-pressure steam enters an evaporation refrigerator 18 from the capillary pipe 17 for vaporization and heat absorption, so that the inside of a freezing section cavity 2 is cooled, the pathological materials are continuously kept fresh through refrigeration of the freezing section cavity 2 and refrigeration of a section box 25, when a semiconductor refrigerator 26 is used, a heating end of the semiconductor refrigerator generates heat, the heat is transmitted through a radiating fin 27, a second driving motor 28 is started, a second fan blade 29 at the output end of the semiconductor refrigerator rotates to generate air flow, under the action of the air flow, the heat outside of the radiating fin 27 flows through a second air outlet 15 to be discharged along with the air flow, when a compressor 6 is used, the heat is generated outside the condenser 9, the first driving motor 10 is started, the first fan blade 11 at the output end of the condenser rotates to generate air flow, and heat outside the condenser 9 is exhausted through the first exhaust port 13 under the action of the air flow.
In one embodiment, an OCT embedding device is further disposed in the frozen section cavity 2, and the OCT embedding device is used for coating an OCT embedding medium on the tissue to be sliced;
the OCT embedding device comprises a U-shaped plate 36, two first sliding rods 37 are arranged in an opening of the U-shaped plate 36 at intervals, the two first sliding rods 37 penetrate through a first sliding block 38, two second sliding rods 39 are further arranged in the first sliding block 38 in a penetrating manner, the two second sliding rods 39 are perpendicular to the two first sliding rods 37, the U-shaped plate 36 is arranged on the inner bottom surface of the frozen section cavity 2, one end of each of the two second sliding rods 39 is provided with a mounting frame 40, an OCT spray gun 41 is detachably arranged in the mounting frame 40, the other end of each of the two second sliding rods 39 is provided with a mounting block 33, the mounting block 33 is rotatably arranged on the upper top surface of a second sliding block 32, the second sliding block 32 is slidably arranged in a sliding rail 31, the sliding rail 31 is arranged on the upper surface of a rotary table 34, a third driving motor 42 is arranged on the lower surface of the rotary table 34, and an output shaft of the third driving motor 42 is connected with the circle center of the rotary table 34;
the inner wall of the slide rail 31 is provided with an electric push rod 35, one end of the electric push rod 35 is arranged at one end of the slide rail 31, the other end of the electric push rod 35 is connected with the second sliding block 32, and the electric push rod 35 is used for adjusting the distance between the second sliding block 32 and the circle center of the rotary table 34.
The working principle and the beneficial effects of the embodiment are as follows:
in order to facilitate quick freezing and slicing of a tissue to be cut, the OCT embedding medium needs to be dripped on the periphery of the tissue, so that the moisture of the tissue can be reduced, and the tissue is easy to form and is not easy to crystallize and break when the tissue is quickly frozen;
when the OCT embedding medium is manually dripped, the tissue needs to be repeatedly taken out of the frozen section cavity 2, and the dripping position is adjusted at any time, so that the purpose of embedding the whole tissue is achieved, and when the tissue is repeatedly taken out of the frozen section cavity 2, the tissue is unstable to freeze, and the specific tissue cannot be exposed under the normal temperature condition, so that the dripping of the OCT embedding medium and the tissue freezing need to be carried out in the frozen section cavity 2;
the mounting rack 40 is provided with an anti-freezing tank, the OCT spray gun 41 is arranged in the anti-freezing tank, and when the tissue needs to be quickly frozen, when the tube body of the OCT embedding medium is placed in the OCT spray gun 41, the anti-freezing tank can avoid the problem that the OCT embedding medium is frozen and cannot be normally dripped in the quick-freezing process;
then, the tissue with the section is placed on a carrying plate, a third driving motor 42 is started, the third driving motor 42 drives the rotary plate 34 to rotate, when the rotary plate 34 rotates, as the mounting block 33 is spaced from the circle center of the rotary plate 34, namely, the mounting block 33 is eccentrically connected with the rotary plate 34, when the rotary plate 34 drives the mounting block to rotate on the second slide block 32, the two second slide bars 39 drive the first slide block 38 to reciprocate on the first slide bar 37, the first slide block 38 reciprocates on the second slide bar 39, the motion track of the mounting frame 40 is the same as that of the mounting block 33 and is circular, when the mounting frame 40 drives the OCT spray gun 41 to move, the OCT spray gun 41 continuously extrudes a tube body of the embedding medium, so that the OCT embedding medium continuously drips out of the tube body and drips on the section tissue of the carrying plate, when the second slide block 32 rotates around the circle center of the rotary plate 34, the electric push rod 35 continuously shrinks, so that the second slide block 32 slides in the slide rail 31, and the electric push rod 35 achieves the purpose of adjusting the spacing between the mounting block 33 and the rotary plate 34, thereby achieving the OCT of the purpose of coating the embedding medium on the section with the OCT in the circle center of the section, and improving the quality of the section of the tissue with the OCT;
simultaneously can avoid the tissue of staff contact pathological change, improve frozen section's security, work efficiency and parcel quality when improving the OCT embedding medium dropwise add can reduce the temperature of OCT embedding medium to near freezing point as far as possible in addition, when guaranteeing through jar that prevents frostbite that the OCT embedding medium does not freeze and drips smoothly, shorten the OCT embedding medium time that freezes, improve section efficiency.
In one embodiment, a gravity sensor is disposed between the semiconductor refrigerator 26 and the slice box 25, the gravity sensor is electrically connected to a data processing module, the data processing module is electrically connected to a drying device, the gravity sensor is used for detecting weight change of the slice box 25, and the data processing module is used for collecting data change of the gravity sensor, so as to start the drying device.
The working principle and the beneficial effects of the embodiment are as follows:
when the tissue is frozen, the gravity sensor detects the weight change of the section box 25, so as to detect the quality change of the tissue, when the tissue is evaporated by the frozen moisture, the gravity sensor detects that the value change is too large, the data processing module counts and analyzes the value, finally, the drying device is started to collect condensed water formed on the surface of the evaporation refrigerator 18, when the quality of the tissue is gradually increased during freezing, the humidity in the section cavity 2 is too large, so that the moisture in the tissue is attached to the surface of the tissue to form ice crystals, the moisture in the tissue cannot be discharged outside, the tissue cannot be adsorbed, the ice crystals cannot be adsorbed, the moisture in the tissue is too much, the moisture in the tissue is obviously reduced, the moisture in the section cavity is obviously reduced, and the purpose of controlling the moisture content in the section cavity by the gravity sensor is achieved;
meanwhile, compared with a method for detecting the humidity change around the tissue through a humidity sensor, the method for detecting the moisture change in the tissue through the gravity sensor can more visually reflect the humidity change in the tissue, and the detection data is more accurate and more visual, but the traditional method for detecting the humidity through the humidity sensor can only detect the humidity change of the air outside the tissue, has large detection error and can not directly detect the humidity inside the tissue, so the method for detecting the humidity change in the tissue through the mass sensor is more efficient and accurate;
in addition, drying device during operation can be collected the condensate water that evaporation refrigerator 18 surface formed to prevent that the condensate water from freezing on evaporation refrigerator 18 surface, influencing evaporation refrigerator's normal work, can also reduce the humidity in the section chamber 2 of freezing simultaneously, prevent that the intracavity humidity is too high to frost.
In one embodiment, the drying device includes a U-shaped frame 43, two ends of the U-shaped frame 43 are disposed on the top surface of the frozen slice chamber 2, the opening of the U-shaped frame 43 is disposed toward the evaporation refrigerator 18, two gears 46 are disposed at intervals on the inner bottom surface of the U-shaped frame 43, the gears 46 are rotatably connected to the U-shaped frame 43, one gear 46 is connected to the output shaft of a fourth driving motor, the two gears 46 are engaged with each other, the fourth driving motor is used for driving the gear 46 to rotate, the surfaces of the two gears 46 are eccentrically provided with first links 45, one ends of the two first links 45 away from the gear 46 are disposed at two ends of a second link 47, the first link 46 is rotatably connected to the gear 46, and the first link 46 is hinged to the second link 47;
a third sliding block 48 is arranged in the middle of the second connecting rod 47, the third sliding block 48 is arranged in the water drainage sliding groove 44 in a sliding manner, and the water drainage sliding groove 44 is arranged on the inner bottom surface of the U-shaped frame 43;
a sponge mounting table 49 is further arranged on the inner bottom surface of the U-shaped frame 43, a clamping groove 51 is formed in the sponge mounting table 49, the clamping groove 51 is used for clamping absorbent cotton, a drainage groove 50 is formed in the inner bottom surface of the clamping groove 51, and one end of the drainage groove 50 penetrates through the side wall of the clamping groove 51 and is communicated with the outside of the mounting table 49;
the fourth driving motor is electrically connected with the data processing module.
The working principle and the beneficial effects of the embodiment are as follows:
when the gravity sensor detects that the tissue mass is increased, the humidity of the air in the frozen section cavity is high, the adsorption efficiency of the drying device needs to be increased, the rotating speed of a fourth driving motor is increased through a data processing module, the fourth driving motor drives the gears 46 to rotate when rotating, the two gears 46 drive one ends of the first connecting rods 45 close to the gears 46 to intermittently approach each other due to meshing rotation, when the first connecting rods 45 intermittently approach each other, the absorbent cotton arranged in the sponge mounting table 49 is extruded, after the absorbent cotton adsorbs condensed water on the surface of the evaporation refrigerator 18, the first connecting rods 45 pressurize the absorbent cotton, so that the condensed water adsorbed in the absorbent cotton is extruded, and the extruded condensed water is discharged through the water discharge groove 50;
by accelerating the rotating speed of the fourth driving motor, the period of the two first connecting rods 45 closing is shortened, the extrusion efficiency of the absorbent cotton is improved, the water absorption efficiency of the absorbent cotton on the evaporation refrigerator 18 is improved, air with high humidity in the freezing slicing cavity is continuously condensed at the evaporation refrigerator 18, and the purpose of reducing the air humidity in the evaporation refrigerator is achieved;
meanwhile, the aim of drying the tissue is fulfilled, and when the air humidity in the frozen section cavity is reduced, the moisture in the tissue is discharged outside, so that the problem that the slicing quality is influenced by excessive ice crystals during tissue slicing is solved;
in addition, when the first connecting rod 45 continuously extrudes the absorbent cotton to discharge the condensed water in the absorbent cotton, the problem that the condensed water in the absorbent cotton is frozen due to low temperature in the frozen section cavity, so that the condensed water on the surface of the evaporation refrigerator 18 cannot be normally adsorbed by the absorbent cotton can be prevented;
when the gravity sensor detects that the tissue quality is obviously lowered, the humidity of air in the freezing section cavity is too low, the excessive drying environment enables the moisture in the tissue to be discharged too much, the rotating speed of the fourth driving motor is reduced, the period that the two first connecting rods 45 are closed is prolonged, the extrusion times of the absorbent cotton are reduced, the extrusion of condensed water in the absorbent cotton is limited, the adsorption efficiency of the absorbent cotton on the condensed water on the surface of the evaporation refrigerator 18 is reduced, the discharging efficiency of the condensed water in the freezing section cavity is reduced, the amount of the condensed water left in the freezing section cavity is increased, the purpose of slowly humidifying the freezing section cavity is achieved, and the problem that the tissue is too dry during slicing, the slicing is powdery and cannot be formed is solved;
the efficiency of the absorbent cotton for absorbing the condensed water is adjusted, so that the air humidity in the freezing slicing cavity is changed, the slicing quality during slicing is adjusted, the absorbent cotton continuously absorbs the condensed water, and the problems that the condensed water formed on the surface cannot be absorbed and discharged outwards during heat exchange of the evaporation refrigerator 19, the condensed water is frozen, and the air humidity in the freezing slicing cavity is overhigh and frosted are solved;
at the same time, the condensed water can be prevented from dripping from the surface of the evaporation refrigerator 18 into the slice cassette 25.
In one embodiment, the drainage channel 50 is connected to a drainage tank 52 through a pipe, the drainage tank 52 is disposed on a surface of the U-shaped frame 43 away from the evaporation refrigerator 18, a piston rod 53 is disposed at one end of the drainage tank 52, one end of the piston rod 53 away from the drainage tank 52 is connected to the third slider 48, the third slider 48 is matched with the second connecting rod 47 for driving the piston rod 53 to slide in the drainage tank 52, a first solenoid valve 54 is disposed between the drainage channel 50 and the drainage tank 52, the drainage tank 52 is further provided with a second solenoid valve 55, one end of the second solenoid valve 55 away from the drainage tank 52 is connected to a nozzle through a pipe, and the nozzle output end is disposed on one side of the compressor 6.
The working principle and the beneficial effects of the embodiment are as follows:
when the water absorption cotton continuously collects the condensed water on the surface of the evaporation refrigerator 18, the collected condensed water is discharged outside through the drainage groove 50, when the third slide block 48 moves in the drainage chute 44 in a reciprocating manner, the third slide block 48 drives the piston rod 53 to slide in the drainage tank 52, when the gear 46 rotates to drive the first connecting rods 45 to approach each other, the water absorption cotton continuously drains water, the piston rod 53 is driven by the third slide block 48 to move to one end far away from the first electromagnetic valve 54, at the moment, the first electromagnetic valve 54 is opened, the second electromagnetic valve 55 is closed, the piston rod 53 moves to enable the drainage tank 52 to absorb water, and the condensed water in the drainage groove 50 is extracted by the drainage tank 52;
when the two first connecting rods 45 are far away from each other, the absorbent cotton is restored to the initial state, the expansion absorbs the condensed water on the surface of the evaporation refrigerator 18, at this time, the piston rod 53 is closed towards the first electromagnetic valve 54, at this time, the first electromagnetic valve 54 is closed, the second electromagnetic valve 55 is opened, and the piston rod 53 is driven by the third slide block 48 to extrude the condensed water in the drainage tank 52 and spray the condensed water on the outer wall of the compressor 6 through the spray head;
because the section intracavity temperature of freezing is low, and the condensate temperature is low, when spraying the condensate that the section intracavity temperature of freezing was low at 6 outer walls of compressor through the shower nozzle, the condensate that the temperature is low can absorb the heat at 6 outer walls of compressor to accelerate 6 radiating efficiency of compressor.
It should be noted that, in this document, relational terms such as first and second, and the like are used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims (8)

1. The utility model provides an intelligent pathological microtome refrigerating plant, includes device shell (1), the inside of device shell (1) is provided with freezing section chamber (2) and refrigeration chamber (3), freezing section chamber (2) are located one side of the inside upper end of device shell (1), refrigeration chamber (3) are located the inside lower extreme of device shell (1), its characterized in that: the refrigerator is characterized in that a compressor (6) is installed at the middle position of the lower end inside the refrigeration cavity (3) through a fixing frame, a high-pressure exhaust pipe (8) is installed at the output end of the compressor (6), a condenser (9) is installed at one end of the outside of the high-pressure exhaust pipe (8), a capillary tube (17) is installed at the output end of the condenser (9), an evaporation refrigerator (18) is installed at one side of the upper end inside the freezing section cavity (2), the input end of the evaporation refrigerator (18) is connected with the capillary tube (17) through a pipeline, a section box (25) is installed at one side of the lower end inside the freezing section cavity (2), a semiconductor refrigerator (26) is installed at the lower end of the section box (25), and the section box (25) is fixedly connected with the refrigeration end of the semiconductor refrigerator (26);
an OCT embedding device is also arranged in the frozen section cavity (2), and the OCT embedding device is used for smearing an OCT embedding medium on the tissue to be sliced;
the OCT embedding device comprises a U-shaped plate (36), two first sliding rods (37) are arranged in an opening of the U-shaped plate (36) at intervals, the two first sliding rods (37) penetrate through a first sliding block (38), two second sliding rods (39) are further arranged in the first sliding block (38) in a penetrating mode, the two second sliding rods (39) are perpendicular to the two first sliding rods (37), the U-shaped plate (36) is arranged on the inner bottom surface of the frozen section cavity (2), a mounting frame (40) is arranged at one end of each of the two second sliding rods (39), an OCT spray gun (41) is detachably arranged in the mounting frame (40), a mounting block (33) is arranged at the other end of each of the two second sliding rods (39), the mounting block (33) is rotatably arranged on the upper top surface of the second sliding block (32), the second sliding block (32) is slidably arranged in the sliding rail (31), the sliding rail (31) is arranged on the upper surface of a rotary table (34), a third driving motor (42) is arranged on the lower surface of the rotary table (34), and the output shaft of the third driving motor (42) is connected with the circle center of the rotary table (34);
the inner wall of the sliding rail (31) is provided with an electric push rod (35), one end of the electric push rod (35) is arranged at one end of the sliding rail (31), the other end of the electric push rod is connected with the second sliding block (32), and the electric push rod (35) is used for adjusting the distance between the second sliding block (32) and the circle center of the rotating disc (34).
2. The intelligent pathological microtome freezing device of claim 1, wherein: the lower extreme of semiconductor cooler (26) runs through and extends to the inside in refrigeration chamber (3), radiating fin (27) are installed to the lower extreme of semiconductor cooler (26), and radiating fin (27) and semiconductor cooler (26) fixed connection, one side that device shell (1) outside is close to radiating fin (27) is provided with second air exit (15), and second air exit (15) and device shell (1) integrated into one piece, the internally mounted of second air exit (15) has second dust screen (16), and second dust screen (16) and second air exit (15) fixed connection.
3. The intelligent microtome freezing apparatus of claim 2, wherein: a second driving motor (28) is installed between the outside of the radiating fin (27) and the second dust screen (16) through a second motor fixing frame (30), a second fan blade (29) is installed at the output end of the second driving motor (28), and the second fan blade (29) is connected with the output end of the second driving motor (28) through a coupler.
4. The intelligent microtome freezing apparatus of claim 1, wherein: the low-pressure air return pipe (7) is installed at the input end of the compressor (6), the low-pressure air return pipe (7) is fixed with the compressor (6) in a sealing mode, the input end of the low-pressure air return pipe (7) is connected with the output end of the evaporation refrigerator (18) through a pipeline, a first exhaust port (13) is formed in one side, close to the condenser (9), of the outer portion of the device shell (1), and the first exhaust port (13) and the device shell (1) are integrally formed.
5. The intelligent pathological microtome freezing device of claim 4, wherein: the utility model discloses a refrigerator, including refrigeration chamber (3), first exhaust opening (13) internally mounted has first dust screen (14), and first dust screen (14) and first exhaust opening (13) fixed connection, refrigeration chamber (3) inside one side that is close to first dust screen (14) installs first driving motor (10) through first motor mount (12), first flabellum (11) are installed to the output of first driving motor (10), and the output of first flabellum (11) and first driving motor (10) passes through the coupling joint.
6. The intelligent microtome freezing apparatus of claim 1, wherein: one side of the inside upper end of device shell (1) is provided with inner chute (19), and inner chute (19) and device shell (1) integrated into one piece, the internally mounted of inner chute (19) has baffle (20), and baffle (20) and inner chute (19) sliding connection, frozen section chamber (2) inner wall installs fixed block (21) for one side of baffle (20) lower extreme, and fixed block (21) and device shell (1) fixed connection, controller (4) are installed to one side of the outside upper end of device shell (1).
7. The intelligent pathological microtome freezing device of claim 6, wherein: electric telescopic handle (22) are installed to the upper end of fixed block (21), and the input of electric telescopic handle (22) and the output electric connection of controller (4), device shell (1) outside is installed inserted bar (23) for one side of baffle (20) lower extreme, and inserted bar (23) run through baffle (20) and extend to the inside in freezing section chamber (2), one side of inserted bar (23) inside is provided with jack (24), and electric telescopic handle (22) and jack (24) looks adaptation.
8. The intelligent pathological microtome freezing device of claim 1, wherein: the device shell (1) is provided with a through window (5), and the through window (5) is close to the frozen section cavity (2).
CN202210643119.5A 2022-06-08 2022-06-08 Intelligent pathological section machine refrigerating plant Active CN115266186B (en)

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