CN115253825B - Low-viscosity material homogenizing device for bio-pharmaceuticals - Google Patents
Low-viscosity material homogenizing device for bio-pharmaceuticals Download PDFInfo
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- CN115253825B CN115253825B CN202210923944.0A CN202210923944A CN115253825B CN 115253825 B CN115253825 B CN 115253825B CN 202210923944 A CN202210923944 A CN 202210923944A CN 115253825 B CN115253825 B CN 115253825B
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- homogenizing
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- homogeneity
- material plate
- pharmaceuticals
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- 239000000463 material Substances 0.000 title claims abstract description 90
- 229960000074 biopharmaceutical Drugs 0.000 title claims abstract description 15
- 230000007246 mechanism Effects 0.000 claims abstract description 24
- 238000005096 rolling process Methods 0.000 claims description 21
- 230000000149 penetrating effect Effects 0.000 claims description 3
- 230000001174 ascending effect Effects 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims 4
- 238000010008 shearing Methods 0.000 abstract description 17
- 230000000694 effects Effects 0.000 abstract description 13
- 238000005457 optimization Methods 0.000 abstract description 2
- 230000009471 action Effects 0.000 description 7
- 238000005381 potential energy Methods 0.000 description 3
- 239000006185 dispersion Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000000630 rising effect Effects 0.000 description 2
- 230000004075 alteration Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 238000000265 homogenisation Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000003032 molecular docking Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000003014 reinforcing effect Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
- B01F31/44—Mixers with shaking, oscillating, or vibrating mechanisms with stirrers performing an oscillatory, vibratory or shaking movement
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
- B01F2101/22—Mixing of ingredients for pharmaceutical or medical compositions
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mixers Of The Rotary Stirring Type (AREA)
Abstract
The invention relates to the technical field of bio-pharmaceuticals and discloses a low-viscosity material homogenizing device for bio-pharmaceuticals, which comprises a stator, an output hole and homogenizing teeth, wherein the bottom of an inner cavity of the stator is rotationally connected with a feeding mechanism, the feeding mechanism comprises a material plate, both sides of the axis of the material plate are provided with input grooves, one side of the material plate, which is close to the inner cavity of the stator, is uniformly provided with annular grooves, the center of the material plate is provided with a guide groove, and the top of the feeding mechanism is rotationally connected with the homogenizing mechanism. This low viscosity material homogeneity device for bio-pharmaceuticals is rotated at a high speed with the direction of rotation of different and bi-lobe homogeneity ring through the control flitch, because of the existence of appeal and centrifugal force, the material through the input groove is the pitch arc flow to stator inner chamber edge promptly, and corresponds by bi-lobe homogeneity ring and leaf piece cooperation shearing, cooperation leaf piece is fluctuated during to be sheared, cooperation annular and homogeneity tooth are sheared to the material passively to very big optimization the homogeneity effect of material and promoted material shearing quality.
Description
Technical Field
The invention relates to the technical field of bio-pharmaceuticals, in particular to a low-viscosity material homogenizing device for bio-pharmaceuticals.
Background
The homogenizer is widely applied to industries such as bio-pharmaceuticals, can emulsify, homogenize, disperse, mix and shear biological raw materials, and the current common homogenizer on the market is poor in emulsification, homogenization, dispersion and shearing effects on materials with the viscosity of less than 10.0000cp, and the same batch of materials are often required to be processed repeatedly and circularly, so that the uniformity and shearing particle size of the materials can not reach the standards, and in order to meet the mixing process of the materials with lower special viscosity, the research on a low-viscosity material homogenizing device is needed to meet the market demand.
Disclosure of Invention
In order to solve the problem that the materials are difficult to use due to poor homogenizing and shearing effects of the materials in the using process of the general homogenizing device for biopharmaceuticals, the purposes of greatly optimizing the homogenizing effects of the materials and improving the shearing quality of the materials are achieved, and the homogenizing device is realized by the following technical scheme: the utility model provides a low viscosity material homogeneity device for bio-pharmaceuticals, includes stator, output hole, homogeneity tooth, stator inner chamber bottom rotates and is connected with feed mechanism, feed mechanism includes the flitch, the input groove has all been seted up to flitch axle center both sides, the flitch is close to one side of stator inner chamber has evenly been seted up the annular, the guide slot has been seted up at the flitch center, feed mechanism top rotation is connected with homogeneity mechanism, homogeneity mechanism includes the biplate homogeneity ring, the equal sliding joint in biplate homogeneity ring left and right sides has the leaf piece, the leaf piece with fixedly connected with butt spring between the biplate homogeneity ring inner chamber upper wall, leaf piece inner wall fixedly connected with telescopic roller.
Further, the motor stator comprises a shaft sleeve, the shaft sleeve is fixedly connected to the top of the stator, a bevel gear sleeve fixedly connected with the two-blade homogenizing ring is rotationally connected to the inner wall of the shaft sleeve, a bevel gear rod penetrating through the bevel gear sleeve is rotationally connected to the top of the inner cavity of the shaft sleeve, and a connecting conical head is connected between the bevel gear rod and the bevel gear sleeve in a meshed mode.
Further, the output hole is symmetrically formed in the left side and the right side of the top of the stator, the edge of the bottom of the output hole is uniformly connected with homogenizing teeth, the edge of the top of the inner cavity of the stator is provided with an arc-shaped slope, and the surface of the arc-shaped slope comprises the homogenizing teeth, so that materials can be sheared and dispersed again before being discharged through the output hole under the action of pressure.
Further, the annular groove is arranged at one side of the periphery of the input groove, and the annular groove is arranged at one side of the surface of the material plate facing the edge in a step-by-step rising mode, so that the material flowing under the action of centrifugal force can be sheared conveniently.
Further, the left side and the right side of the guide connecting groove respectively comprise concave parts corresponding to the telescopic rolling rods, the elastic force of the telescopic rolling rods is far greater than that of the abutting springs, when the telescopic rolling rods rotate relative to the guide connecting groove, the movable blade blocks are driven to vertically fluctuate and shear, and when the blade blocks are acted by material resistance, the telescopic rolling rods can ensure the stability of rotating connection between the telescopic rolling rods and the guide connecting grooves.
Further, the conical tooth bar is fixedly connected with the material plate, so that the conical tooth bar drives the material plate to adjust the feeding direction.
Furthermore, the connecting conical head is in driving connection with the top of the shaft sleeve, so that the conical tooth rod and the conical tooth sleeve can be driven to reversely rotate.
Compared with the prior art, the invention has the following beneficial effects:
1. this low viscosity material homogeneity device for bio-pharmaceuticals, when high-speed rotation of two leaf homogeneity ring is through controlling, utilize the input groove to attract outside material, synchronous control flitch is rotated at a high speed with the direction of rotation of different and two leaf homogeneity rings, because of the existence of appeal and centrifugal force, the material through the input groove is the pitch arc flow promptly to stator inner chamber edge, and correspond by two leaf homogeneity rings and leaf piece cooperation homogeneity shearing, the guide slot makes flexible roller lever can cooperate the butt spring during this, drive leaf piece intermittent type up-and-down fluctuation, the reinforcing is to the material shearing effect, when the material receives huge pressure effect and displacement in the stator inner chamber, the passive shearing effect of cooperation annular and homogeneity tooth to the material, the material can obtain pressure shearing and dispersion after the input groove, before discharging the output hole, very big optimization the homogeneity effect of material and promoted the material shearing quality.
2. According to the low-viscosity material homogenizing device for the bio-pharmaceuticals, the elastic force of the telescopic rolling rod is far greater than that of the abutting spring, when the leaf block is not influenced by material resistance, the abutting spring is superior to the telescopic rolling rod to match with the leaf block to move, when the leaf block is influenced by material resistance and cannot move in a fluctuating manner, the telescopic rolling rod can automatically compress elastic potential energy on the premise of ensuring that the leaf block continuously rotates relative to a material plate so as to maintain stable connection relation with the guide groove, and a stable shearing mechanism of equipment is ensured by the design.
Drawings
FIG. 1 is a front cross-sectional view of the present invention;
FIG. 2 is a front cross-sectional view of a stator connection portion of the present invention;
FIG. 3 is a front cross-sectional view of a blade attachment portion of the present invention;
FIG. 4 is an enlarged view of FIG. 2 at A;
FIG. 5 is a front cross-sectional view of the connecting portion of the input slot of the present invention;
FIG. 6 is a top cross-sectional view of a dual-bladed homogenizing ring attachment portion of the present invention;
fig. 7 is a top cross-sectional view of a web attachment portion of the present invention.
In the figure: 1. a shaft sleeve; 2. conical tooth sleeve; 3. a conical toothed bar; 4. a connecting cone head; 5. a stator; 6. an output aperture; 7. homogenizing teeth; 8. a feed mechanism; 81. a material plate; 82. an input slot; 83. a ring groove; 84. a guide groove; 9. a homogenizing mechanism; 91. a double-bladed homogenizing ring; 92. leaf blocks; 93. abutting against the spring; 94. a telescopic rolling rod.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
The embodiment of the low-viscosity material homogenizing device for bio-pharmaceuticals is as follows:
referring to fig. 1-7, a low-viscosity material homogenizing device for bio-pharmaceuticals comprises a stator 5, an output hole 6 and homogenizing teeth 7, wherein the output hole 6 is symmetrically arranged on the left side and the right side of the top of the stator 5, the homogenizing teeth 7 are uniformly connected to the edge of the bottom of the output hole 6, an arc slope is arranged on the edge of the top of an inner cavity of the stator 5, the surface of the arc slope comprises the homogenizing teeth 7, and the homogenizing teeth can be sheared and dispersed again before materials are discharged through the output hole 6 under the action of pressure.
The bottom of the inner cavity of the stator 5 is rotationally connected with a feeding mechanism 8, the feeding mechanism 8 comprises a material plate 81, input grooves 82 are formed in two sides of the axis of the material plate 81, annular grooves 83 are uniformly formed in one side, close to the inner cavity of the stator 5, of the material plate 81, the annular grooves 83 are arranged on one side, located on the periphery of the input grooves 82, of the surface of the material plate 81, and the annular grooves 83 are arranged in a step-by-step ascending mode on one side, facing the edge, of the material plate 81, so that materials flowing under the action of centrifugal force can be sheared conveniently.
The guide connection groove 84 has been seted up at the flitch 81 center, guide connection groove 84 left and right sides is including the concave part that corresponds with flexible round bar 94 respectively, the elasticity of flexible round bar 94 is greater than the elasticity of butt spring 93 far away, when the relative guide connection groove 84 of flexible round bar 94 rotates of being convenient for, it cuts to drive leaf piece 92 to rise and fall, when leaf piece 92 receives the material resistance effect, flexible round bar 94 can guarantee the stability of rotating with guide connection groove 84 between, feed mechanism 8 top rotates and is connected with homogeneity mechanism 9, homogeneity mechanism 9 includes bi-leaf homogeneity ring 91, bi-leaf homogeneity ring 91 left and right sides all slip joint has leaf piece 92, fixedly connected with butt spring 93 between leaf piece 92 and the bi-leaf homogeneity ring 91 inner chamber upper wall, leaf piece 92 inner wall fixedly connected with flexible round bar 94.
The elastic force of the telescopic rolling rod 94 is far greater than that of the abutting spring 93, when the leaf block 92 is not affected by material resistance, the abutting spring 93 is better than that of the telescopic rolling rod 94 to be matched with the leaf block 92 to move, when the leaf block 92 is affected by material resistance and cannot move up and down, the telescopic rolling rod 94 can automatically compress elastic potential energy on the premise of ensuring that the leaf block 92 continuously rotates relative to the material plate 81 so as to maintain stable connection relation with the guide connection groove 84, and the design ensures a stable shearing mechanism of equipment.
The shaft sleeve 1 is fixedly connected to the top of the stator 5, the conical tooth sleeve 2 fixedly connected with the double-leaf homogenizing ring 91 is rotationally connected to the inner wall of the shaft sleeve 1, the conical tooth rod 3 penetrating through the conical tooth sleeve 2 is rotationally connected to the top of the inner cavity of the shaft sleeve 1, the conical tooth rod 3 is fixedly connected with the material plate 81, the conical tooth rod 3 is convenient to drive the material plate 81 to adjust the feeding direction, the conical tooth rod 3 is meshed with the conical tooth sleeve 2, the connecting conical head 4 is connected to the top of the shaft sleeve 1 in a driving mode, and the conical tooth rod 3 and the conical tooth sleeve 2 are convenient to drive to reversely rotate.
When the double-leaf homogenizing ring 91 is controlled to rotate at a high speed, external materials are attracted by the input groove 82, the material plate 81 is synchronously controlled to rotate at a high speed in different rotation directions with the double-leaf homogenizing ring 91, the materials passing through the input groove 82 flow in an arc line to the edge of the inner cavity of the stator 5 due to the attraction and the centrifugal force, and correspondingly are matched with the double-leaf homogenizing ring 91 and the leaf block 92 to be sheared in a homogenizing way, the guide groove 84 enables the telescopic rolling rod 94 to be matched with the abutting spring 93 to drive the leaf block 92 to intermittently move up and down, the shearing effect of the materials is enhanced, and when the materials are displaced in the inner cavity of the stator 5 under the action of huge pressure, the materials can be sheared and dispersed under the action of the pressure by the matching annular groove 83 and the homogenizing teeth 7 before being discharged out of the output hole 6 after passing through the input groove 82, so that the homogenizing effect of the materials is greatly optimized, and the shearing quality of the materials is improved.
Working principle: when in use, the connecting conical head 4 is driven by an external drive to rotate the conical tooth rod 3 and the conical tooth sleeve 2 at a high speed in the opposite direction, the corresponding double-leaf homogenizing ring 91 and the material plate 81 rotate at a high speed in the opposite direction, and the material can enter the inner cavity of the stator 5 from the input groove 82 upwards by utilizing the attractive force generated by the double-leaf homogenizing ring 91, the movement direction of the input groove 82 is opposite to that of the double-leaf homogenizing ring 91, the material passing through the input groove 82 flows in an arc line to the inner cavity edge of the stator 5 due to the existence of the attractive force and the centrifugal force, and the corresponding double-leaf homogenizing ring 91 and the leaf block 92 are matched and sheared, during the period, the telescopic rolling rod 94 moves circularly relative to the guide groove 84, the left side and the right side of the guide groove 84 respectively comprise a concave part, so that the telescopic rolling rod 94 can be matched and abutted against the spring 93 to drive the leaf block 92 to intermittently move up and down, the shearing effect on the materials is enhanced, annular grooves 83 which are arranged in a stepwise rising way and correspond to the initial moving direction of the materials to be sheared exist on the surface of the batch plate 81, the batch materials are forced to move upwards under the action of huge pressure in the inner cavity of the stator 5, each homogenizing tooth 7 can shear and disperse the materials again under pressure just before the materials are discharged through the output holes 6, so that the homogenizing effect of the materials is greatly optimized and the shearing quality of the materials is improved, during the period, the elasticity of the telescopic rolling rod 94 is far greater than that of the abutting spring 93, when the blade block 92 is not influenced by the material resistance, the abutting spring 93 is better than the telescopic rolling rod 94 to match the blade block 92 to move, and when the blade block 92 is influenced by the material resistance and can not move up and down, the telescopic rolling rod 94 can automatically compress the elastic potential energy on the premise of ensuring the continuous rotation of the blade block 92 relative to the material plate 81, to maintain a stable connection with the docking slot 84, this design thus ensures a stable shear mechanism for the device.
Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made therein without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (5)
1. The utility model provides a low viscosity material homogeneity device for bio-pharmaceuticals, includes stator (5), output hole (6), homogeneity tooth (7), its characterized in that:
the feeding mechanism (8) is rotationally connected to the bottom of an inner cavity of the stator (5), the feeding mechanism (8) comprises a material plate (81), input grooves (82) are formed in two sides of an axis of the material plate (81), annular grooves (83) are uniformly formed in one side, close to the inner cavity of the stator (5), of the material plate (81), guide grooves (84) are formed in the center of the material plate (81), the top of the feeding mechanism (8) is rotationally connected with a homogenizing mechanism (9), the homogenizing mechanism (9) comprises a double-leaf homogenizing ring (91), leaf blocks (92) are slidably clamped on the left side and the right side of the double-leaf homogenizing ring (91), abutting springs (93) are fixedly connected between the leaf blocks (92) and the upper wall of the inner cavity of the double-leaf homogenizing ring (91), and telescopic rolling rods (94) are fixedly connected to the inner walls of the leaf blocks (92).
The stator is characterized by further comprising a shaft sleeve (1), wherein the shaft sleeve (1) is fixedly connected to the top of the stator (5), a bevel gear sleeve (2) fixedly connected with the double-blade homogenizing ring (91) is rotationally connected to the inner wall of the shaft sleeve (1), a bevel gear rod (3) penetrating through the bevel gear sleeve (2) is rotationally connected to the top of an inner cavity of the shaft sleeve (1), and a connecting conical head (4) is connected between the bevel gear rod (3) and the bevel gear sleeve (2) in a meshed manner;
the annular groove (83) is arranged at one side of the periphery of the input groove (82), and the annular groove (83) is arranged in a step-by-step ascending mode at one side of the surface of the material plate (81) facing the edge;
the left side and the right side of the guide connection groove (84) respectively comprise concave parts corresponding to the telescopic rolling rods (94); the elastic force of the telescopic rolling rod (94) is far greater than that of the abutting spring (93).
2. The low viscosity material homogenizing apparatus for biological pharmaceuticals of claim 1, wherein:
the output holes (6) are symmetrically formed in the left side and the right side of the top of the stator (5), and the bottom edges of the output holes (6) are uniformly connected with homogenizing teeth (7).
3. The low viscosity material homogenizing apparatus for biological pharmaceuticals of claim 1, wherein:
an arc slope surface is arranged at the top edge of the inner cavity of the stator (5), and the surface of the arc slope surface comprises the homogenizing teeth (7).
4. The low viscosity material homogenizing apparatus for biological medicine according to claim 2, wherein:
the bevel gear rod (3) is fixedly connected with the material plate (81).
5. The low viscosity material homogenizing apparatus for biological pharmaceuticals of claim 1, wherein:
the connecting conical head (4) is in driving connection with the top of the shaft sleeve (1).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210923944.0A CN115253825B (en) | 2022-08-02 | 2022-08-02 | Low-viscosity material homogenizing device for bio-pharmaceuticals |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210923944.0A CN115253825B (en) | 2022-08-02 | 2022-08-02 | Low-viscosity material homogenizing device for bio-pharmaceuticals |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN115253825A CN115253825A (en) | 2022-11-01 |
| CN115253825B true CN115253825B (en) | 2024-02-06 |
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| CN202210923944.0A Active CN115253825B (en) | 2022-08-02 | 2022-08-02 | Low-viscosity material homogenizing device for bio-pharmaceuticals |
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Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1986003432A1 (en) * | 1984-12-05 | 1986-06-19 | Daniel Bidon | Centrifugal spray apparatus |
| RU74633U1 (en) * | 2008-02-06 | 2008-07-10 | ООО Научно-производственная экологическая фирма "ЭКО-технология" | TECHNOLOGICAL SYSTEM OF HYDROMETALLURGICAL EQUIPMENT FOR INTEGRATED PROCESSING OF CHLORIDE WASTE OF TITANIUM-MAGNESIUM PRODUCTION |
| CN202410558U (en) * | 2012-01-06 | 2012-09-05 | 无锡赫普轻工设备技术有限公司 | Liquid rotary material suction type efficient mixing homogenization equipment |
| CN203291774U (en) * | 2013-06-14 | 2013-11-20 | 常州苏特轴承制造有限公司 | Automatic textile auxiliary agent dispersion machine |
| CN204194055U (en) * | 2014-11-06 | 2015-03-11 | 南通市通州区三槐机械制造有限公司 | The superfine homogeneous mulser of pottery |
| CN109745892A (en) * | 2017-11-02 | 2019-05-14 | 肖文敏 | The refiner of easy cleaning |
| CN212790538U (en) * | 2020-07-19 | 2021-03-26 | 南通图海机械有限公司 | Multistage high-speed shearing emulsification dispersion machine |
-
2022
- 2022-08-02 CN CN202210923944.0A patent/CN115253825B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1986003432A1 (en) * | 1984-12-05 | 1986-06-19 | Daniel Bidon | Centrifugal spray apparatus |
| RU74633U1 (en) * | 2008-02-06 | 2008-07-10 | ООО Научно-производственная экологическая фирма "ЭКО-технология" | TECHNOLOGICAL SYSTEM OF HYDROMETALLURGICAL EQUIPMENT FOR INTEGRATED PROCESSING OF CHLORIDE WASTE OF TITANIUM-MAGNESIUM PRODUCTION |
| CN202410558U (en) * | 2012-01-06 | 2012-09-05 | 无锡赫普轻工设备技术有限公司 | Liquid rotary material suction type efficient mixing homogenization equipment |
| CN203291774U (en) * | 2013-06-14 | 2013-11-20 | 常州苏特轴承制造有限公司 | Automatic textile auxiliary agent dispersion machine |
| CN204194055U (en) * | 2014-11-06 | 2015-03-11 | 南通市通州区三槐机械制造有限公司 | The superfine homogeneous mulser of pottery |
| CN109745892A (en) * | 2017-11-02 | 2019-05-14 | 肖文敏 | The refiner of easy cleaning |
| CN212790538U (en) * | 2020-07-19 | 2021-03-26 | 南通图海机械有限公司 | Multistage high-speed shearing emulsification dispersion machine |
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