CN115253825A - Low viscosity material homogeneity device for bio-pharmaceuticals - Google Patents
Low viscosity material homogeneity device for bio-pharmaceuticals Download PDFInfo
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- CN115253825A CN115253825A CN202210923944.0A CN202210923944A CN115253825A CN 115253825 A CN115253825 A CN 115253825A CN 202210923944 A CN202210923944 A CN 202210923944A CN 115253825 A CN115253825 A CN 115253825A
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- homogenizing
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- low viscosity
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- 239000000463 material Substances 0.000 title claims abstract description 84
- 229960000074 biopharmaceutical Drugs 0.000 title claims abstract description 22
- 230000007246 mechanism Effects 0.000 claims abstract description 24
- 238000005096 rolling process Methods 0.000 claims description 12
- 230000001174 ascending effect Effects 0.000 claims description 2
- 230000000149 penetrating effect Effects 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 19
- 238000010008 shearing Methods 0.000 description 23
- 230000009471 action Effects 0.000 description 6
- 239000006185 dispersion Substances 0.000 description 5
- 238000005381 potential energy Methods 0.000 description 3
- 238000000034 method Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000001360 synchronised effect Effects 0.000 description 2
- 230000004075 alteration Effects 0.000 description 1
- 230000002337 anti-port Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000003032 molecular docking Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000003014 reinforcing effect Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000011345 viscous material Substances 0.000 description 1
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
- B01F31/44—Mixers with shaking, oscillating, or vibrating mechanisms with stirrers performing an oscillatory, vibratory or shaking movement
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
- B01F2101/22—Mixing of ingredients for pharmaceutical or medical compositions
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- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mixers Of The Rotary Stirring Type (AREA)
Abstract
The invention relates to the technical field of bio-pharmaceuticals and discloses a low-viscosity material homogenizing device for bio-pharmaceuticals, which comprises a stator, an output hole and homogenizing teeth, wherein the bottom of an inner cavity of the stator is rotatably connected with a feeding mechanism, the feeding mechanism comprises a material plate, both sides of the axis of the material plate are respectively provided with an input groove, one side of the material plate, which is close to the inner cavity of the stator, is uniformly provided with a ring groove, the center of the material plate is provided with a guide connection groove, and the top of the feeding mechanism is rotatably connected with a homogenizing mechanism. This low viscosity material homogeneity device for bio-pharmaceuticals rotates with the rotation direction of different and bilobed homogeneity ring at a high speed through the control flitch, because of the existence of appeal and centrifugal force, the material via the input groove is the pitch arc to stator inner chamber edge promptly and flows, and corresponds and is cuted by bilobed homogeneity ring and the cooperation of leaf piece, and the cooperation leaf piece is undulant during to be cuted, cooperates ring groove and homogeneity tooth to the material is cuted passively to the very big homogeneity effect that has optimized the material has just promoted the material and has sheared the quality.
Description
Technical Field
The invention relates to the technical field of biological pharmacy, in particular to a low-viscosity material homogenizing device for biological pharmacy.
Background
The homogenizer wide application is in trades such as bio-pharmaceuticals, it can emulsify to biological raw materials, the homogeneity, the dispersion, mix, the shearing, general homogenizer is to the material below the material consistency 10.0000cp on the existing market, the emulsification that plays, the homogeneity, the dispersion, the shearing effect is not good, often need pass through the reciprocal processing of circulation many times to same batch of material, the homogeneity and the shearing particle diameter of material still can't reach standard nevertheless, for satisfying the lower material mixing process of special consistency, it meets the market demand to need to study a low viscous material homogeneity device of a section urgently.
Disclosure of Invention
In order to solve the problem that materials are difficult to use due to poor homogenizing and shearing effects of the materials in the using process of the common homogenizing device for the bio-pharmaceuticals, the purposes of greatly optimizing the homogenizing effect of the materials and improving the shearing quality of the materials are achieved, the homogenizing device for the bio-pharmaceuticals is realized by the following technical scheme: the utility model provides a low viscosity material homogeneity device for bio-pharmaceuticals, includes stator, delivery outlet, homogeneity tooth, stator cavity bottom is rotated and is connected with feed mechanism, feed mechanism includes the flitch, the input groove has all been seted up to flitch axle center both sides, the flitch is close to stator cavity's one side has evenly seted up the annular, the flitch center has been seted up and has been led the groove that connects, the feed mechanism top is rotated and is connected with homogeneity mechanism, homogeneity mechanism includes two leaf homogeneity rings, the equal slip joint in two leaf homogeneity ring left and right sides has the leaf piece, the leaf piece with fixedly connected with butt spring between the two leaf homogeneity ring cavity upper wall, the flexible roller rod of leaf piece inner wall fixedly connected with.
The stator further comprises a shaft sleeve, the shaft sleeve is fixedly connected to the top of the stator, a bevel gear sleeve fixedly connected with the double-blade homogeneous ring is rotatably connected to the inner wall of the shaft sleeve, a bevel gear rod penetrating through the bevel gear sleeve is rotatably connected to the top of an inner cavity of the shaft sleeve, and a connecting conical head is connected between the bevel gear rod and the bevel gear sleeve in a meshed mode.
Furthermore, the delivery outlet in stator top left and right sides symmetry is seted up, delivery outlet bottom edge evenly is connected with the homogeneity tooth, stator cavity top edge has seted up the arc domatic, the domatic surface of arc is including the homogeneity tooth is convenient for receive the pressure effect before the delivery outlet is discharged at the material, can be sheared the dispersion once more.
Furthermore, the annular groove is located the peripheral one side of input groove, the annular groove in the flitch surface is arranged in the form that rises step by step towards one side of edge, is convenient for cut the material that receives the centrifugal force effect to flow.
Further, lead and connect the groove left and right sides respectively including with the sunk part that flexible roller bar corresponds, the elasticity of flexible roller bar is far more than the elasticity of butt spring is convenient for flexible roller bar leads the groove relatively and rotates the time, drives the leaf piece and undulates about the shearing, when the leaf piece receives material resistance effect, flexible roller bar can guarantee with lead and connect the stability of being connected of rotating between the groove.
Furthermore, the taper tooth rod is fixedly connected with the material plate, so that the taper tooth rod can drive the material plate to adjust the feeding direction.
Furthermore, the coupling conical head is in driving connection with the top of the shaft sleeve, so that the conical tooth rod and the conical tooth sleeve can be driven to rotate reversely.
Compared with the prior art, the invention has the following beneficial effects:
1. this low viscosity material homogeneity device for bio-pharmaceuticals, when rotating at a high speed through control bilobed homogeneity ring, utilize the input groove to attract outside material, the synchronous control flitch rotates with the rotation direction high speed of different and bilobed homogeneity ring, because of appeal and centrifugal force's existence, the material via the input groove is the pitch arc flow to stator inner chamber edge promptly, and correspond by bilobed homogeneity ring and the homogeneity of leaf piece cooperation shearing, the guide connects the groove during this period and makes flexible hob can cooperate the butt spring, drive the up-and-down fluctuation motion of leaf piece intermittent type nature, the reinforcing is to material shearing effect, when the material receives huge pressure effect and displacement in the stator inner chamber, cooperation annular and the passive shearing effect of homogeneity tooth to the material, the material can be after the input groove, obtain pressure shearing and dispersion before discharging the delivery outlet, thereby very big homogeneity effect of having optimized the material and promoted material shearing quality.
2. This low viscosity material homogeneity device for bio-pharmaceuticals, elasticity through flexible roller bar is far greater than the elasticity of butt spring, when the leaf piece does not receive material resistance effect influence, the butt spring is superior to flexible roller bar cooperation leaf piece motion promptly, when the leaf piece receives material resistance effect and unable fluctuation, under the prerequisite of guaranteeing that the leaf piece lasts the pivoted for the flitch, flexible roller bar can automatic compression elasticity potential energy, in order to maintain with leading the stable connection relation in groove, thereby this design has guaranteed the stable mechanism of cuting of equipment.
Drawings
FIG. 1 is a front cross-sectional view of the present invention;
FIG. 2 is a front sectional view of a stator connection portion of the present invention;
FIG. 3 is a front cross-sectional view of a blade block attachment portion of the present invention;
FIG. 4 is an enlarged view taken at A in FIG. 2;
FIG. 5 is a front sectional view of a connection portion of an input slot of the present invention;
FIG. 6 is a top cross-sectional view of a two-lobed homogeneous ring junction of the present invention;
fig. 7 is a top sectional view of the material plate connecting portion of the present invention.
In the figure: 1. a shaft sleeve; 2. a bevel gear sleeve; 3. a bevel gear rod; 4. a connecting conical head; 5. a stator; 6. an output aperture; 7. homogenizing teeth; 8. a feeding mechanism; 81. a material plate; 82. an input slot; 83. a ring groove; 84. a guide connection groove; 9. a homogenizing mechanism; 91. a bileaf homogenizing ring; 92. a leaf mass; 93. an abutment spring; 94. a telescopic rolling rod.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
An example of the device for homogenizing a low viscosity material for biopharmaceuticals is as follows:
referring to fig. 1-7, a low viscosity material homogenizer for bio-pharmaceuticals comprises a stator 5, an output hole 6, and homogenizing teeth 7, wherein the output hole 6 is symmetrically formed on the left and right sides of the top of the stator 5, the homogenizing teeth 7 are uniformly connected to the bottom edge of the output hole 6, an arc-shaped slope is formed on the top edge of the inner cavity of the stator 5, and the homogenizing teeth 7 are included on the surface of the arc-shaped slope, so that the material can be sheared and dispersed again before being discharged through the output hole 6 under the action of pressure.
The flitch 81 center has been seted up and has been led and connect groove 84, lead and connect the groove 84 left and right sides respectively including the depressed part that corresponds with flexible roller bar 94, the elasticity of flexible roller bar 94 is far greater than the elasticity of butt spring 93, be convenient for flexible roller bar 94 leads when connecting the groove 84 rotation relatively, drive vane 92 undulate and cut from top to bottom, when vane 92 receives the material resistance effect, flexible roller bar 94 can guarantee with lead and connect the stability of being connected of rotating between groove 84, 8 tops of feed mechanism rotate and be connected with homogeneity mechanism 9, homogeneity mechanism 9 includes bilobed homogeneity ring 91, bilobed homogeneity ring 91 the equal slip joint in both sides has vane 92, fixedly connected with butt spring 93 between vane 92 and the bilobed homogeneity ring 91 inner chamber upper wall, vane 92 inner wall fixedly connected with flexible roller bar 94.
The elastic force of the telescopic rolling rod 94 is far greater than that of the abutting spring 93, when the leaf block 92 is not influenced by material resistance, the abutting spring 93 is superior to the telescopic rolling rod 94 to match with the leaf block 92 to move, when the leaf block 92 cannot move up and down under the action of the material resistance, on the premise that the leaf block 92 continuously rotates relative to the material plate 81, the telescopic rolling rod 94 can automatically compress elastic potential energy to maintain the stable connection relation with the guide connection groove 84, and the design ensures the stable shearing mechanism of the equipment.
1 fixed connection of axle sleeve is at 5 tops of stator, 1 inner wall of axle sleeve rotates and is connected with the awl tooth cover 2 with two leaf homogeneity ring 91 fixed connection, 1 inner chamber top of axle sleeve rotates and is connected with the awl tooth pole 3 that runs through awl tooth cover 2, fixed connection between awl tooth pole 3 and the flitch 81, the awl tooth pole 3 of being convenient for drives the flitch 81 and adjusts the feeding position, the meshing is connected with the connection conical head 4 between awl tooth pole 3 and the awl tooth cover 2, connection conical head 4 is connected in the drive of 1 top of axle sleeve, be convenient for drive awl tooth pole 3 and the 2 antiport of awl tooth cover.
When the double-blade homogenizing ring 91 is controlled to rotate at a high speed, the input groove 82 is utilized to attract external materials, the synchronous control plate 81 rotates at a high speed in the rotating direction of the different double-blade homogenizing ring 91, due to the existence of attraction and centrifugal force, the materials flowing through the input groove 82 form arc line to the edge of the inner cavity of the stator 5, and are correspondingly matched with homogenizing shearing by the double-blade homogenizing ring 91 and the blade block 92, the guide connecting groove 84 enables the telescopic rolling rod 94 to be matched with the abutting spring 93 during the period, the blade block 92 is driven to move intermittently up and down, the shearing effect of the materials is enhanced, when the materials are displaced under the action of huge pressure in the inner cavity of the stator 5, the annular groove 83 and the homogenizing teeth 7 are matched to perform passive shearing action on the materials, the materials can be subjected to pressure shearing and dispersing after passing through the input groove 82 and before being discharged out of the output hole 6, and therefore the homogenizing effect of the materials is greatly optimized and the shearing quality of the materials is improved.
The working principle is as follows: when in use, the connecting conical head 4 is driven by an external drive to enable the conical tooth rod 3 and the conical tooth sleeve 2 to reversely rotate at a high speed, the corresponding double-blade homogenizing ring 91 and the material plate 81 rotate at a high speed in an opposite direction, the double-blade homogenizing ring 91 generates attraction force on external materials, the materials can be enabled to upwards enter the inner cavity of the stator 5 from the input groove 82, the movement direction of the input groove 82 is opposite to that of the double-blade homogenizing ring 91, the materials passing through the input groove 82 flow in an arc line towards the edge of the inner cavity of the stator 5 due to the existence of the attraction force and centrifugal force, the corresponding double-blade homogenizing ring 91 and the blade block 92 are matched for homogenizing shearing, the telescopic rolling rod 94 circularly moves relative to the guide connecting groove 84 during the period, the left side and the right side of the guide connecting groove 84 respectively comprise a concave part, so that the telescopic rolling rod 94 can be matched with the abutting spring 93 to drive the blade block 92 to intermittently move up and down, the shearing effect on the materials is enhanced, the annular grooves 83 which are arranged in a gradually ascending manner and correspond to the motion direction of the materials at the initial shearing stage exist on the surface of the matching material plate 81, the matching materials are forced to move upwards under the action of huge pressure in the inner cavity of the stator 5, each homogenizing tooth 7 performs pressure shearing and dispersion on the materials again before the materials are discharged through the output hole 6, the homogenizing effect of the materials is greatly optimized, the shearing quality of the materials is improved, in the period, the elastic force of the telescopic rolling rod 94 is far greater than that of the abutting spring 93, when the leaf block 92 is not influenced by the resistance of the materials, the abutting spring 93 is better than the movement of the telescopic rolling rod 94 matching with the leaf block 92, and when the leaf block 92 cannot move up and down under the action of the resistance of the materials, under the premise that the leaf block 92 continuously rotates relative to the material plate 81, the telescopic rolling rod 94 can automatically compress elastic potential energy, to maintain a stable connection with docking slot 84, which thereby ensures a stable shearing mechanism for the device.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (9)
1. A low viscosity material homogeneity device for bio-pharmaceuticals, includes stator (5), delivery port (6), homogeneity tooth (7), its characterized in that: stator (5) inner chamber bottom is rotated and is connected with feed mechanism (8), feed mechanism (8) include flitch (81), input groove (82) have all been seted up to flitch (81) axle center both sides, flitch (81) are close to annular (83) have evenly been seted up to one side of stator (5) inner chamber, flitch (81) center has been seted up and has been led groove (84), feed mechanism (8) top is rotated and is connected with homogeneity mechanism (9), homogeneity mechanism (9) are including two leaf homogeneity ring (91), the equal slip joint in both sides of two leaf homogeneity ring (91) left and right sides has leaf piece (92), leaf piece (92) with fixedly connected with butt spring (93) between two leaf homogeneity ring (91) inner chamber upper wall, leaf piece (92) inner wall fixedly connected with rolls pole (94) telescopically.
2. A device for homogenizing a low viscosity material for biopharmaceuticals as in claim 1, wherein: the stator is characterized by further comprising a shaft sleeve (1), the shaft sleeve (1) is fixedly connected to the top of the stator (5), a bevel gear sleeve (2) fixedly connected with the double-blade homogenizing ring (91) is rotatably connected to the inner wall of the shaft sleeve (1), a bevel gear rod (3) penetrating through the bevel gear sleeve (2) is rotatably connected to the top of the inner cavity of the shaft sleeve (1), and a connecting conical head (4) is connected between the bevel gear rod (3) and the bevel gear sleeve (2) in a meshed mode.
3. A device for homogenizing a low viscosity material for biopharmaceuticals as in claim 1, wherein: the output holes (6) are symmetrically formed in the left side and the right side of the top of the stator (5), and homogenizing teeth (7) are uniformly connected to the edge of the bottom of the output holes (6).
4. A device for homogenizing a low viscosity material for biopharmaceuticals as in claim 1, wherein: the top edge of the inner cavity of the stator (5) is provided with an arc-shaped slope surface, and the surface of the arc-shaped slope surface comprises the homogenizing teeth (7).
5. A device for homogenizing low viscosity materials for bio-pharmaceuticals according to claim 1, wherein: the ring grooves (83) are arranged on one side of the periphery of the input groove (82), and the ring grooves (83) are arranged on one side of the surface of the material plate (81) facing the edge in a manner of ascending step by step.
6. A device for homogenizing low viscosity materials for bio-pharmaceuticals according to claim 1, wherein: the left side and the right side of the guide connecting groove (84) respectively comprise a concave part corresponding to the telescopic rolling rod (94).
7. A device for homogenizing low viscosity material for bio-pharmaceuticals according to claim 2, wherein: the taper tooth rod (3) is fixedly connected with the material plate (81).
8. A device for homogenizing low viscosity material for bio-pharmaceuticals according to claim 2, wherein: the connecting conical head (4) is in driving connection with the top of the shaft sleeve (1).
9. A device for homogenizing a low viscosity material for biopharmaceuticals as in claim 1, wherein: the elastic force of the telescopic rolling rod (94) is far larger than that of the abutting spring (93).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210923944.0A CN115253825B (en) | 2022-08-02 | 2022-08-02 | Low-viscosity material homogenizing device for bio-pharmaceuticals |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210923944.0A CN115253825B (en) | 2022-08-02 | 2022-08-02 | Low-viscosity material homogenizing device for bio-pharmaceuticals |
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| Publication Number | Publication Date |
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| CN115253825A true CN115253825A (en) | 2022-11-01 |
| CN115253825B CN115253825B (en) | 2024-02-06 |
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| CN202210923944.0A Active CN115253825B (en) | 2022-08-02 | 2022-08-02 | Low-viscosity material homogenizing device for bio-pharmaceuticals |
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Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1986003432A1 (en) * | 1984-12-05 | 1986-06-19 | Daniel Bidon | Centrifugal spray apparatus |
| RU74633U1 (en) * | 2008-02-06 | 2008-07-10 | ООО Научно-производственная экологическая фирма "ЭКО-технология" | TECHNOLOGICAL SYSTEM OF HYDROMETALLURGICAL EQUIPMENT FOR INTEGRATED PROCESSING OF CHLORIDE WASTE OF TITANIUM-MAGNESIUM PRODUCTION |
| CN202410558U (en) * | 2012-01-06 | 2012-09-05 | 无锡赫普轻工设备技术有限公司 | Liquid rotary material suction type efficient mixing homogenization equipment |
| CN203291774U (en) * | 2013-06-14 | 2013-11-20 | 常州苏特轴承制造有限公司 | Automatic textile auxiliary agent dispersion machine |
| CN204194055U (en) * | 2014-11-06 | 2015-03-11 | 南通市通州区三槐机械制造有限公司 | The superfine homogeneous mulser of pottery |
| CN109745892A (en) * | 2017-11-02 | 2019-05-14 | 肖文敏 | The refiner of easy cleaning |
| CN212790538U (en) * | 2020-07-19 | 2021-03-26 | 南通图海机械有限公司 | Multistage high-speed shearing emulsification dispersion machine |
-
2022
- 2022-08-02 CN CN202210923944.0A patent/CN115253825B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1986003432A1 (en) * | 1984-12-05 | 1986-06-19 | Daniel Bidon | Centrifugal spray apparatus |
| RU74633U1 (en) * | 2008-02-06 | 2008-07-10 | ООО Научно-производственная экологическая фирма "ЭКО-технология" | TECHNOLOGICAL SYSTEM OF HYDROMETALLURGICAL EQUIPMENT FOR INTEGRATED PROCESSING OF CHLORIDE WASTE OF TITANIUM-MAGNESIUM PRODUCTION |
| CN202410558U (en) * | 2012-01-06 | 2012-09-05 | 无锡赫普轻工设备技术有限公司 | Liquid rotary material suction type efficient mixing homogenization equipment |
| CN203291774U (en) * | 2013-06-14 | 2013-11-20 | 常州苏特轴承制造有限公司 | Automatic textile auxiliary agent dispersion machine |
| CN204194055U (en) * | 2014-11-06 | 2015-03-11 | 南通市通州区三槐机械制造有限公司 | The superfine homogeneous mulser of pottery |
| CN109745892A (en) * | 2017-11-02 | 2019-05-14 | 肖文敏 | The refiner of easy cleaning |
| CN212790538U (en) * | 2020-07-19 | 2021-03-26 | 南通图海机械有限公司 | Multistage high-speed shearing emulsification dispersion machine |
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