CN115252715A - Composition for improving functional constipation - Google Patents
Composition for improving functional constipation Download PDFInfo
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- CN115252715A CN115252715A CN202210296460.8A CN202210296460A CN115252715A CN 115252715 A CN115252715 A CN 115252715A CN 202210296460 A CN202210296460 A CN 202210296460A CN 115252715 A CN115252715 A CN 115252715A
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- 206010010774 Constipation Diseases 0.000 title claims abstract description 46
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- 238000002360 preparation method Methods 0.000 claims description 18
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Abstract
The invention belongs to the technical field of medicines, and particularly relates to a composition for improving functional constipation, which comprises platycladi seed, cooked rhubarb, fructus cannabis, radix rehmanniae recen, white paeony root, radix ophiopogonis, radix bupleuri, cassia seed, rhizoma cyperi, angelica sinensis, mulberry, bighead atractylodes rhizome, cistanche, codonopsis pilosula, polygonum multiflorum and radix achyranthis bidentatae according to a specific matching proportion of a formula, and is used for treating the functional constipation, wherein the platycladi seed is prepared from the following components in parts by weight: 3-5 parts of: the cooked rhubarb is prepared from the following components in parts by weight: 0.5-2.5 parts: the fructus cannabis is prepared from the following components in parts by weight: 1-2 parts of: the dried rehmannia root is prepared from the following components in parts by weight: 3-5 parts of: the white paeony root is prepared from the following components in parts by weight: 0.5-1 part: the radix ophiopogonis is prepared from the following components in parts by weight: 5-10 parts of the traditional Chinese medicine composition, has reasonable structure, and has the effects of purging heat, nourishing yin, relaxing bowel, soothing liver, regulating qi, warming interior, dispelling cold, tonifying qi, nourishing blood, tonifying spleen and tonifying kidney.
Description
Technical Field
The invention relates to the technical field of medicines, in particular to a composition for improving functional constipation.
Background
Functional Constipation (FC) is a common disease of the digestive system, and is a syndrome without obvious organic lesions and mainly manifested by reduced defecation frequency, reduced stool volume, dry stool and hard defecation. Epidemiological data show that the incidence rate of constipation in China is 3 to 17 percent. The incidence rate of chronic functional constipation in people of 18-70 years old in Beijing area of China is 6.07%. With the accelerated development of our society, the pace of life of people is increasingly accelerated, the emotional tension degree is increased by the competitive pressure, and the incidence of functional constipation is increased year by year under the influence of various comprehensive factors such as increasingly refined dietary structure and the like, thereby seriously influencing the life quality of modern people. Constipation can not only cause the occurrence of anus diseases such as hemorrhoids, fissures and the like, but also induce and aggravate various cardiovascular and cerebrovascular diseases, seriously even induce colon cancer and endanger life.
For the treatment of constipation, two main treatments, pharmaceutical treatment and non-pharmaceutical treatment, are currently used. The drug therapy mainly comprises various purgatives, gastrointestinal motility promoting drugs, cellulose preparations and the like, and the traditional western medicines are easy to tolerate. The traditional Chinese medicine for treating constipation has a history of thousands of years, has potential advantages compared with traditional western medicines, and no relevant report about the composition is found at present.
To this end, we propose a novel composition for improving functional constipation to solve the above problems.
Disclosure of Invention
This section is for the purpose of summarizing some aspects of embodiments of the invention and to briefly introduce some preferred embodiments. In this section, as well as in the abstract and the title of the invention of this application, certain simplifications or omissions may be made to avoid obscuring the purpose of the section, the abstract and the title, and such simplifications or omissions are not intended to limit the scope of the invention.
The present invention has been made in view of the problems occurring in the prior art.
Therefore, the invention aims to provide a composition for improving functional constipation, which has the effects of purging heat, nourishing yin, relaxing bowel, soothing liver, regulating qi, warming interior, dispelling cold, tonifying qi, nourishing blood, tonifying spleen and tonifying kidney.
To solve the above technical problem, according to one aspect of the present invention, the present invention provides the following technical solutions:
a composition for improving functional constipation comprises platycladi seed, cooked rhubarb, fructus cannabis, radix rehmanniae, white peony root, dwarf lilyturf tuber, radix bupleuri, cassia seed, rhizoma cyperi, angelica, mulberry, bighead atractylodes rhizome, desertliving cistanche, codonopsis pilosula, polygonum multiflorum and achyranthes bidentata according to a specific matching proportion of a formula, is used for treating functional constipation, and has the effects of purging heat and nourishing yin, relaxing bowel, soothing liver and regulating qi, warming interior and dispelling cold, tonifying qi and nourishing blood, and tonifying spleen and kidney:
wherein the content of the first and second substances,
the platycladi seed is prepared from the following components in parts by weight: 3-5 parts of:
the cooked rhubarb is prepared from the following components in parts by weight: 0.5-2.5 parts:
the fructus cannabis is prepared from the following components in parts by weight: 1-2 parts of:
the dried rehmannia root is prepared from the following components in parts by weight: 3-5 parts of:
the white paeony root is prepared from the following components in parts by weight: 0.5-1 part:
the radix ophiopogonis is prepared from the following components in parts by weight: 5-10 parts of:
the bupleurum is prepared by the following components in parts by weight: 3-5 parts of:
the cassia seed is prepared from the following components in parts by weight: 2-4 parts of:
the rhizoma cyperi is prepared from the following components in parts by weight: 2-3 parts of:
the Chinese angelica is prepared from the following components in parts by weight: 2-3 parts of:
the mulberry is prepared from the following components in parts by weight: 0.5-1 part:
the white atractylodes rhizome is prepared from the following components in parts by weight: 3-5 parts of:
the desert cistanche is prepared from the following components in parts by weight: 2-3 parts of:
the formula is prepared from the following components in parts by weight: 5-10 parts of:
the polygonum multiflorum is prepared from the following components in parts by weight: 5-10 parts of:
the achyranthes bidentata is prepared from the following components in parts by weight: 3-5 parts.
As a preferable embodiment of the composition for improving functional constipation according to the present invention, wherein: the preparation process comprises the steps of drying, cleaning, moxibustion, sterilization, cutting and mixing Chinese medicinal materials such as platycladi seed, cooked rhubarb, fructus cannabis, radix rehmanniae recen, white paeony root, radix ophiopogonis, radix bupleuri, cassia seed, rhizoma cyperi, angelica sinensis, mulberry, bighead atractylodes rhizome, cistanche, codonopsis pilosula, polygonum multiflorum, radix achyranthis bidentatae and the like.
As a preferable embodiment of the composition for improving functional constipation according to the present invention, wherein: the combined medicine is an oral preparation.
As a preferable embodiment of the composition for improving functional constipation according to the present invention, wherein: the oral preparation of the pharmaceutical composition is granules.
As a preferable embodiment of the composition for improving functional constipation according to the present invention, wherein: the granule is administered orally with boiled water.
As a preferable embodiment of the composition for improving functional constipation according to the present invention, wherein: the dosage of the granules is as follows: 15mg-20mg for adults and 5mg-10mg for children.
As a preferable embodiment of the composition for improving functional constipation according to the present invention, wherein: the granule is administered half an hour after meals.
As a preferable embodiment of the composition for improving functional constipation according to the present invention, wherein: is suitable for relieving or treating mild constipation of patients of all ages.
Compared with the prior art, the invention has the beneficial effects that: the traditional Chinese medicine composition is convenient to take, has small side effect and lasting drug effect, has the effects of purging heat, nourishing yin, relaxing bowel, soothing liver, regulating qi, warming interior, dispelling cold, tonifying qi, nourishing blood, tonifying spleen and tonifying kidney, and further improves the curative effect of treating functional constipation by traditional Chinese medicines.
Detailed Description
The present invention will be described in detail with reference to the following embodiments in order to make the above objects, features and advantages of the present invention more comprehensible.
In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention, but the present invention may be practiced in other ways than those specifically described herein, and it will be readily apparent to those of ordinary skill in the art that the present invention may be practiced without departing from the spirit and scope of the present invention.
Next, in describing the embodiments of the present invention in detail, the cross-sectional view illustrating the structure of the device is not partially enlarged in a general scale for convenience of description, and the schematic diagram is only an example, which should not limit the scope of the present invention. In addition, the three-dimensional dimensions of length, width and depth should be included in the actual fabrication.
In order to make the objects, technical solutions and advantages of the present invention more apparent, embodiments of the present invention will be described in further detail below.
Example 1
A composition for improving functional constipation comprises platycladi seed, cooked rhubarb, fructus cannabis, radix rehmanniae, white peony root, radix ophiopogonis, radix bupleuri, semen cassiae, rhizoma cyperi, angelica sinensis, mulberry, bighead atractylodes rhizome, cistanche, codonopsis pilosula, polygonum multiflorum and radix achyranthis bidentatae according to a specific matching proportion of a formula, is used for treating functional constipation, and has the effects of purging heat and nourishing yin, relaxing bowel, soothing liver and regulating qi, warming interior and dispelling cold, tonifying qi and nourishing blood, and tonifying spleen and kidney:
wherein the content of the first and second substances,
the platycladi seed is prepared from the following components in parts by weight: 3 parts of:
the cooked rhubarb is prepared from the following components in parts by weight: 0.5 part:
the fructus cannabis is prepared from the following components in parts by weight: 1 part:
the dried rehmannia root is prepared from the following components in parts by weight: 3 parts of:
the white peony root is prepared from the following components in parts by weight: 0.5 part:
the radix ophiopogonis is prepared from the following components in parts by weight: 5 parts of:
the bupleurum is prepared by the following components in parts by weight: 3 parts of:
the cassia seed is prepared from the following components in parts by weight: 2 parts of:
the nutgrass galingale rhizome is prepared from the following components in parts by weight: 2 parts of:
the angelica is prepared from the following components in parts by weight: 2 parts of:
the mulberry is prepared from the following components in parts by weight: 0.5 part:
the white atractylodes rhizome is prepared from the following components in parts by weight: 3 parts of:
the desert cistanche is prepared from the following components in parts by weight: 2 parts of:
the Chinese medicinal preparation is prepared from the following components in parts by weight: 5 parts of:
the polygonum multiflorum is prepared from the following components in parts by weight: 5 parts of:
the achyranthes bidentata is prepared from the following components in parts by weight: and 3 parts.
Wherein: the preparation process comprises the steps of drying, cleaning, moxibustion, sterilization, cutting and mixing the Chinese medicinal materials such as platycladi seed, cooked rhubarb, fructus cannabis, radix rehmanniae recen, white paeony root, dwarf lilyturf tuber, bupleurum root, cassia seed, nutgrass galingale rhizome, chinese angelica, mulberry, largehead atractylodes rhizome, desertliving cistanche, codonopsis pilosula, tuber fleeceflower root, twotooth achyranthes root and the like.
Wherein: the combined medicine is an oral preparation.
Wherein: the oral preparation of the pharmaceutical composition is granules.
Wherein: the granule is administered orally with boiled water.
Wherein: the dosage of the granules is as follows: 15mg-20mg for adult and 5mg-10mg for children.
Wherein: the granule is administered half an hour after meals.
Wherein: is suitable for relieving or treating mild constipation of patients of all ages
Example 2
A composition for improving functional constipation comprises platycladi seed, cooked rhubarb, fructus cannabis, radix rehmanniae, white peony root, radix ophiopogonis, radix bupleuri, semen cassiae, rhizoma cyperi, angelica sinensis, mulberry, bighead atractylodes rhizome, cistanche, codonopsis pilosula, polygonum multiflorum and radix achyranthis bidentatae according to a specific matching proportion of a formula, is used for treating functional constipation, and has the effects of purging heat and nourishing yin, relaxing bowel, soothing liver and regulating qi, warming interior and dispelling cold, tonifying qi and nourishing blood, and tonifying spleen and kidney:
wherein the content of the first and second substances,
the platycladi seed is prepared from the following components in parts by weight: 4 parts of:
the cooked rhubarb is prepared from the following components in parts by weight: 1 part of:
the fructus cannabis is prepared from the following components in parts by weight: 1.5 parts of:
the dried rehmannia root is prepared from the following components in parts by weight: 4 parts of:
the white paeony root is prepared from the following components in parts by weight: 1 part of:
the radix ophiopogonis is prepared from the following components in parts by weight: 10 parts of:
the bupleurum is prepared by the following components in parts by weight: 4 parts of:
the cassia seed is prepared from the following components in parts by weight: 3 parts of:
the nutgrass galingale rhizome is prepared from the following components in parts by weight: 3 parts of:
the Chinese angelica is prepared from the following components in parts by weight: 3 parts of:
the mulberry is prepared from the following components in parts by weight: 1 part of:
the white atractylodes rhizome is prepared from the following components in parts by weight: 4 parts of:
the desert cistanche is prepared from the following components in parts by weight: 3 parts of:
the Chinese medicinal preparation is prepared from the following components in parts by weight: 10 parts of:
the polygonum multiflorum is prepared from the following components in parts by weight: 10 parts of:
the achyranthes bidentata is prepared from the following components in parts by weight: 4 parts.
Wherein: the preparation process comprises the steps of drying, cleaning, moxibustion, sterilization, cutting and mixing the Chinese medicinal materials such as platycladi seed, cooked rhubarb, fructus cannabis, radix rehmanniae recen, white paeony root, dwarf lilyturf tuber, bupleurum root, cassia seed, nutgrass galingale rhizome, chinese angelica, mulberry, largehead atractylodes rhizome, desertliving cistanche, codonopsis pilosula, tuber fleeceflower root, twotooth achyranthes root and the like.
Wherein: the combined medicine is an oral preparation.
Wherein: the oral preparation of the pharmaceutical composition is granules.
Wherein: the granule is administered orally with boiled water.
Wherein: the dosage of the granules is as follows: 15mg-20mg for adult and 5mg-10mg for children.
Wherein: the granule is administered half an hour after meals.
Wherein: is suitable for relieving or treating mild constipation of patients of all ages
Example 3
A composition for improving functional constipation comprises platycladi seed, cooked rhubarb, fructus cannabis, radix rehmanniae, white peony root, radix ophiopogonis, radix bupleuri, semen cassiae, rhizoma cyperi, angelica sinensis, mulberry, bighead atractylodes rhizome, cistanche, codonopsis pilosula, polygonum multiflorum and radix achyranthis bidentatae according to a specific matching proportion of a formula, is used for treating functional constipation, and has the effects of purging heat and nourishing yin, relaxing bowel, soothing liver and regulating qi, warming interior and dispelling cold, tonifying qi and nourishing blood, and tonifying spleen and kidney:
wherein, the first and the second end of the pipe are connected with each other,
the platycladi seed is prepared from the following components in parts by weight: 5 parts of:
the cooked rhubarb is prepared from the following components in parts by weight: 2.5 parts of:
the fructus cannabis is prepared from the following components in parts by weight: 2 parts of:
the dried rehmannia root is prepared from the following components in parts by weight: 5 parts of:
the white paeony root is prepared from the following components in parts by weight: 1 part of:
the radix ophiopogonis is prepared from the following components in parts by weight: 10 parts of:
the bupleurum is prepared by the following components according to parts by weight: 5 parts of:
the cassia seed is prepared from the following components in parts by weight: 4 parts of:
the nutgrass galingale rhizome is prepared from the following components in parts by weight: 3 parts of:
the Chinese angelica is prepared from the following components in parts by weight: 3 parts of:
the mulberry is prepared from the following components in parts by weight: 1 part of:
the white atractylodes rhizome is prepared from the following components in parts by weight: 5 parts of:
the desert cistanche is prepared from the following components in parts by weight: 3 parts of:
the formula is prepared from the following components in parts by weight: 10 parts of:
the polygonum multiflorum is prepared from the following components in parts by weight: 10 parts of:
the achyranthes bidentata is prepared from the following components in parts by weight: 5 parts of the raw materials.
Wherein: the preparation process comprises the steps of drying, cleaning, moxibustion, sterilization, cutting and mixing the Chinese medicinal materials such as platycladi seed, cooked rhubarb, fructus cannabis, radix rehmanniae, white paeony root, dwarf lilyturf tuber, bupleurum root, cassia seed, rhizoma cyperi, chinese angelica, mulberry, largehead atractylodes rhizome, desertliving cistanche, codonopsis pilosula, polygonum multiflorum, achyranthes root and the like.
Wherein: the combined medicine is an oral preparation.
Wherein: the oral preparation of the pharmaceutical composition is granules.
Wherein: the granule is administered orally with boiled water.
Wherein: the dosage of the granules is as follows: 15mg-20mg for adult and 5mg-10mg for children.
Wherein: the granule is administered half an hour after meals.
Wherein: is suitable for relieving or treating mild constipation of patients of all ages
1. General data:
150 patients with chronic constipation (excluding intestinal organic lesions) are selected for clinic visit. The treatment group, the control group 1 and the control group 2 are divided by a random digital method, and 50 patients are treated in each group.
Wherein, the treatment groups comprise 29 male cases and 21 female cases; age 35-75 years, mean age (51.2 ± 3.26) years; the course of disease (10.28 +/-4.63) months, and the defecation interval time (4.56 +/-1.78) days. Control group 1, male 27, female 23; age 36-72 years, mean age (49.8 ± 3.66) years; the disease course (9.75 +/-3.21) months, and the defecation interval time (4.32 +/-1.84) days. Control group 2, male 30, female 20; age 34-71 years, mean age (50.6 ± 4.17) years; the course of the disease (9.84 +/-4.75) months, and the defecation interval time (5.15 +/-2.06) days. The three groups of the traditional Chinese medicine are statistically processed in the aspects of sex ratio, age, disease course and the like, have no significance (P is more than 0.05) and have comparability.
2. The treatment method comprises the following steps:
control 1 group: the patient takes cisapride 10mg 3 times daily half an hour before a meal.
Control 2 group: the patient takes 10mg of probiotics 3 times a day half an hour before meal.
Treatment groups: the powder prepared in the embodiment 1 of the invention is 10-15mg each time, and is taken half an hour after meals.
The patients in 3 groups all take the medicine continuously for 2 months, and the curative effect is judged after 2 months. The patient is during the administration of the drug. The food is prohibited from being eaten by greasy, spicy and uncooked foods, and the treatment effect is ensured. During the treatment period, other Chinese and western medicines for treating the disease are not taken.
3. The curative effect standard is as follows:
and (3) healing: defecation is normal, and accompanying symptoms disappear completely;
the effect is shown: the constipation is obviously improved, the interval time and the stool quality are close to normal, or the defecation is slightly flat and the interval time is within 72 hours, and most of accompanying symptoms disappear;
the method has the following advantages: the defecation time interval is shortened by 1 day, or the dry feces is improved, and the accompanying symptoms are all improved;
and (4) invalidation: constipation and accompanying symptoms were not improved.
4. Statistical method
Statistical analysis is carried out on the data by using statistical software SPSS20.0, and the counting data are tested by adopting x 2; the measured data is expressed by mean plus or minus standard deviation, and t test is carried out; p < 0.05 indicated significant variability between the two groups.
5. Therapeutic results
Three groups of patients have no abscission case in the treatment process, and all the three groups of patients complete clinical observation. Compared with the total curative effect after 2 treatment courses, the cure rate of 72 percent and the total effective rate of 100 percent in the treatment group are both superior to those of the control group 1 or 2, and the difference of the cure rate is very obvious. The cure rate of the control group 2 is better than that of the control group 1, but is obviously inferior to that of the treatment group, and the difference is extremely obvious, which indicates that the treatment effect of the invention can not be achieved by randomly changing the formula.
While the invention has been described above with reference to an embodiment, various modifications may be made and equivalents may be substituted for elements thereof without departing from the scope of the invention. In particular, the various features of the embodiments disclosed herein may be used in any combination, provided that there is no structural conflict, and the combinations are not exhaustively described in this specification merely for the sake of brevity and resource conservation. Therefore, it is intended that the invention not be limited to the particular embodiments disclosed, but that the invention will include all embodiments falling within the scope of the appended claims.
Claims (8)
1. A composition for ameliorating functional constipation, comprising: comprises semen boitae, cooked rhubarb, fructus cannabis, radix rehmanniae recen, white paeony root, dwarf lilyturf tuber, radix bupleuri, cassia seed, rhizoma cyperi, angelica, mulberry, largehead atractylodes rhizome, desertliving cistanche, radix codonopsitis, tuber fleeceflower root and twotooth achyranthes root, and is prepared according to the specific matching proportion of the formula:
wherein, the first and the second end of the pipe are connected with each other,
the platycladi seed is prepared from the following components in parts by weight: 3-5 parts of:
the cooked rhubarb is prepared from the following components in parts by weight: 0.5-2.5 parts:
the fructus cannabis is prepared from the following components in parts by weight: 1-2 parts:
the dried rehmannia root is prepared from the following components in parts by weight: 3-5 parts of:
the white peony root is prepared from the following components in parts by weight: 0.5-1 part:
the radix ophiopogonis is prepared from the following components in parts by weight: 5-10 parts of:
the bupleurum is prepared by the following components in parts by weight: 3-5 parts of:
the cassia seed is prepared from the following components in parts by weight: 2-4 parts of:
the rhizoma cyperi is prepared from the following components in parts by weight: 2-3 parts of:
the Chinese angelica is prepared from the following components in parts by weight: 2-3 parts of:
the mulberry is prepared from the following components in parts by weight: 0.5-1 part:
the white atractylodes rhizome is prepared from the following components in parts by weight: 3-5 parts of:
the desert cistanche is prepared from the following components in parts by weight: 2-3 parts of:
the formula is prepared from the following components in parts by weight: 5-10 parts of:
the polygonum multiflorum is prepared from the following components in parts by weight: 5-10 parts of:
the achyranthes root is prepared from the following components in parts by weight: 3-5 parts.
2. The composition for improving functional constipation according to claim 1, wherein: the preparation process comprises the steps of drying, cleaning, moxibustion, sterilization, cutting and mixing the Chinese medicinal materials such as platycladi seed, prepared rhubarb, fructus cannabis, radix rehmanniae recen, white paeony root, dwarf lilyturf tuber, chinese thorowax root, cassia seed, nutgrass galingale rhizome, chinese angelica, mulberry, largehead atractylodes rhizome, desertliving cistanche, codonopsis pilosula, polygonum multiflorum, achyranthes root and the like.
3. The composition for improving functional constipation according to any one of claims 1 to 2, wherein: the combined medicine is an oral preparation.
4. The composition for improving functional constipation according to claim 3, wherein: the oral preparation of the pharmaceutical composition is granules.
5. The composition for improving functional constipation according to claim 4, wherein: the granule is administered orally with boiled water.
6. The composition for improving functional constipation according to claim 4, wherein: the dosage of the granules is as follows: 15mg-20mg for adults and 5mg-10mg for children.
7. The composition for improving functional constipation according to claim 4, wherein: the granule is administered half an hour after meal.
8. The composition for improving functional constipation according to claim 4, wherein: is suitable for relieving or treating mild constipation of patients of all ages.
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| CN103784717A (en) * | 2012-12-14 | 2014-05-14 | 青岛菲特电器科技有限公司 | Orally taken Chinese medicinal formula for treating constipation |
| CN104435679A (en) * | 2014-11-20 | 2015-03-25 | 王正琦 | Traditional Chinese medicine mixture for treating habitual constipation |
| CN107596099A (en) * | 2016-07-12 | 2018-01-19 | 陈焕微 | A kind of Chinese medicine for treating senile chronic functional consitipation |
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2022
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101129771A (en) * | 2007-08-27 | 2008-02-27 | 尹克华 | Traditional Chinese medicine for treating bradykinesia type constipation |
| CN101181508A (en) * | 2007-11-15 | 2008-05-21 | 王玉鑫 | Chinese medicine prescription orally taken for curing constipation |
| CN102078506A (en) * | 2009-11-27 | 2011-06-01 | 赵莉 | Traditional Chinese medicine composition for constipation |
| CN102846947A (en) * | 2012-08-31 | 2013-01-02 | 霍山县中医院 | Chinese herbal medicine for treating habitual constipation |
| CN103784717A (en) * | 2012-12-14 | 2014-05-14 | 青岛菲特电器科技有限公司 | Orally taken Chinese medicinal formula for treating constipation |
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| CN107596099A (en) * | 2016-07-12 | 2018-01-19 | 陈焕微 | A kind of Chinese medicine for treating senile chronic functional consitipation |
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Application publication date: 20221101 |