CN115252675A - Hair-beautifying skin-care soft chewable tablet for dogs and preparation method thereof - Google Patents
Hair-beautifying skin-care soft chewable tablet for dogs and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/55—Linaceae (Flax family), e.g. Linum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
- A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
Abstract
The invention provides a soft chewable tablet for skin care and hair care for dogs and a preparation method thereof. The soft chewable tablet for beautifying and protecting the skin of the dog provided by the invention has the synergistic effect of a plurality of components, and fundamentally improves and maintains the health of the skin and the hair of the dog under the condition of supplementing fatty acid, trace elements, vitamins and the like. The tablet prepared by the invention has unique dosage form, is convenient to feed and has good palatability, the soft chewable tablet is adopted, and the soft chewable tablet has lower hardness and higher moisture content than the conventional tablet or hard chewable tablet, so that the soft chewable tablet is more easily loved by pet dogs and is more convenient to feed.
Description
Technical Field
The invention relates to the field of animal health products, in particular to a soft chewable tablet for beautifying hair and protecting skin for dogs and a preparation method thereof.
Background
With the rapid development of domestic pet industry and the change of social structure, the attention of people to pets is continuously promoted, which becomes one of important motivations for promoting the development of pet industry. The pet-raising population is increasing, and pet-raising groups mainly behind 80 and 90 pay more attention to the health and beauty of pets, and the fur health of pets not only affects the overall appearance of pets, but also directly reflects the health status and diet status of pets.
At present, due to the influence of certain physiological characteristics of pet dog species and external environment and other factors, the pet dog is easy to have the problems of hair color fading, hair loss, skin diseases and the like. In order to improve and solve the health problem of the pet dog fur, a plurality of functional products are also appeared on the market, including shampoo for caring dog fur, dog food with the function of beautifying and brightening hair, health food for caring dog fur and the like.
However, the external skin and hair care shampoo can improve the fur state of the pet dog in a short time, and cannot solve the fundamental problem well. The existing dog food or hair-beautifying health-care food for dogs cannot well solve the problem of fur, or has high cost and is difficult to be accepted by the public; or the product has single function, can not solve the problem fundamentally and is not beneficial to the long-term health of the pet dog; or poor palatability, and is difficult to feed to pet dogs to fully perform, for example, CN108125048A discloses a functional food for caring fur of pet dogs and cats. In order to meet the health care requirement of pets, the hair-beautifying skin-care pet health care product with high stability and good adaptability needs to be further developed.
Disclosure of Invention
The invention provides a soft chewable skin-care hair-beautifying tablet for dogs, which comprises active ingredients, an adhesive, a wetting agent, a flavoring agent, a preservative, a disintegrating agent, a lubricant and a filler, wherein the active ingredients comprise linseed oil microcapsule powder and vitamin E acetate.
In some embodiments, the active ingredients include linseed oil microcapsule powder, vitamin E acetate, and zinc methionine.
In some embodiments, the active ingredients include linseed oil microcapsule powder, vitamin E acetate, zinc methionine, and DHA.
In some typical embodiments, the active ingredients are linseed oil microcapsule powder, vitamin E acetate, zinc methionine, DHA and EPA.
In some embodiments, the soft chewable skin caring tablet for dogs consists of 25-35% of active ingredient, 2-10% of binder, 15-30% of wetting agent, 10-20% of flavoring agent, 0.2-1% of preservative, 2-10% of disintegrant, 0.2-1% of lubricant and 20-35% of filler by weight.
In some embodiments, the binder is selected from one or more of starch, hypromellose, sodium carboxymethylcellulose, or polyvinylpyrrolidone.
In some embodiments, the humectant is selected from one or more of water, glycerin, soybean oil, corn oil, or polyethylene glycol.
In some embodiments, the flavoring agent is selected from one or more of spray dried plasma protein powder, chicken essence, beef essence, or chicken liver powder.
In some embodiments, the preservative is selected from one or more of potassium sorbate, sodium benzoate, calcium propionate, or sodium diacetate.
In some embodiments, the disintegrant is selected from one or more of sodium carboxymethyl starch, crospovidone, croscarmellose sodium, or low substituted hydroxypropyl cellulose.
In some embodiments, the lubricant is selected from one or more of magnesium stearate, colloidal silicon dioxide, or talc.
In some embodiments, the filler is selected from one or more of microcrystalline cellulose, pregelatinized starch, sucrose, or mannitol.
In some embodiments, the present invention provides a soft chewable skin-care tablet for dogs comprising 32.7% active ingredient, 4% binder, 23% humectant, 12% flavoring agent, 0.2% preservative, 5% disintegrant, 0.8% lubricant, and 22.3% filler.
In some exemplary embodiments, the present invention provides a soft chewable tablet for caring skin and hair for dogs, which comprises the following components:
in some embodiments, the present invention provides a soft chewable skin caring tablet for dogs, consisting of 25.43% active ingredient, 2% binder, 20% humectant, 12% flavoring agent, 0.2% preservative, 4% disintegrant, 1% lubricant, and 30.37% filler.
In some exemplary embodiments, the present invention provides a soft chewable tablet for caring skin and hair for dogs, which comprises the following components:
in some embodiments, the present invention provides a soft chewable skin caring tablet for dogs, comprising 28.57% of active ingredient, 5% of binder, 18% of wetting agent, 15% of flavoring agent, 0.3% of preservative, 5% of disintegrant, 1% of lubricant and 27.13% of filler.
In some exemplary embodiments, the present invention provides a soft chewable tablet for caring skin and hair for dogs, which comprises the following components:
in some embodiments, the present invention provides a soft chewable skin caring tablet for dogs, consisting of 27.25% of active ingredient, 8% of binder, 19% of wetting agent, 15% of flavoring agent, 0.4% of preservative, 3% of disintegrant, 0.7% of lubricant and 26.65% of filler.
In some exemplary embodiments, the present invention provides a soft chewable tablet for caring skin and hair for dogs, which comprises the following components:
in some embodiments, the chewable tablets provided by the invention are used for improving or solving the hair color fading, hair loss and skin diseases of pet dogs.
In another aspect, the invention also provides a preparation method of the hair-beautifying skin-care soft chewable tablet for dogs, which comprises the following steps:
(1) Sieving active ingredient, adhesive, flavoring agent, antiseptic, disintegrating agent and filler respectively, and mixing;
(2) Slowly adding a wetting agent into the solid mixture, and fully and uniformly mixing to obtain wet particles;
(3) Drying the wet granules prepared above at low temperature without ventilation;
(4) Sieving the dried wet granules;
(5) Adding lubricant into the dried granules, uniformly mixing, pressing into soft chewable tablets in a tablet press, controlling hardness, and packaging with aluminum plastic.
In some embodiments, step (3) dries the wet granulation at a temperature of no more than 40 ℃ for a time period of 1 to 3 hours, controlling the moisture of the wet granulation to be maintained between 5 to 10%.
In some embodiments, the number of screens screened in step (4) is less than 40 mesh, preferably 16-24 mesh.
In some embodiments, step (5) controls the hardness not to exceed 2kg.
On the other hand, the weight of the soft chewable tablet for skin care and hair beautification of dogs provided by the invention is 3.0 +/-0.15 g, and the usage and dosage are as follows: 1/2 tablet per day for 1-6 weeks initially, less than 10 pounds; 10-20 lbs, 1 tablet per day; 20-40 lbs, 2 tablets per day; 40-60 pounds, 4 tablets per day. Over 60 pounds, 6 tablets per day. The maintenance dose was halved after 6 weeks.
The invention has the advantages of
1. The synergistic effect of various components can improve and maintain the health of the skin and hair of the dog fundamentally under the multiple conditions of the supplement of fatty acid, trace elements, vitamins and the like. Linseed oil, derived from the flax plant, is a safe natural source with high omega fatty acids content and can nourish the skin and hair. The linseed oil on the market is mainly in the form of a traditional cooking oil package and has a narrow application range. Polyunsaturated fatty acids are prone to oxidation and rancidity during high temperature heating, and their oxides may have many adverse effects on the body. In addition, the flavor is unique, which results in a limitation in the form in which it is ingested, and thus there is a need to solve the problems of suppression and stability of the flavor. The linseed oil microcapsule powder is easier to take, and can solve the problem of easy oxidation and putrefaction in the storage process, thereby improving the bioavailability and effectiveness of the linseed oil microcapsule powder in organisms. The trace element zinc is an important essential mineral substance and plays an important role in maintaining healthy skin and hair. Zinc methionine is a stable chelate formed by combining zinc ions and amino acid molecules through coordination bonds, has good stability, reduces the influence of substances such as pH value, lipid, fiber, gastric acid and the like in the digestion process, and is beneficial to the full absorption and utilization of metal ions by organisms. EPA and DHA are helpful for keeping the skin and the hair moist, preventing the skin and the hair from drying and desquamation, maintaining the physiological barrier function of the skin and resisting the invasion of external disease sources. In addition, vitamin E acetate helps limit fatty acid oxidation, stimulate hair growth, soften dry skin, smooth skin irritation, reduce skin scar damage and promote scar healing.
2. Has unique dosage form, convenient feeding and good palatability. The product is a soft chewable tablet, which has lower hardness and higher moisture content than conventional or hard chewable tablets, and is therefore more popular with pet dogs and more convenient to feed. And compared with other dosage forms such as paste, powder or liquid preparation, the dosage of the feed is easier to control and more convenient to store. In addition, the meat essence and other phagostimulants added into the product have rich and mellow flavor and good palatability and mouth tolerance.
3. The method has the advantages of simple process, convenient operation and stable product properties and performance. Compared with other soft chewable tablet extruders or molding machines, the final implementation form of the invention can be obtained by adopting a conventional tablet press in drug production, and the invention has simple process and convenient operation. In addition, accelerated tests prove that the soft chewable tablet has stable properties and performance, does not have mildew and deterioration phenomenon, and has stable indexes such as water content, tablet weight, contents of various active ingredients and the like.
Detailed Description
The technical scope of the present invention is not limited to the above description, and those skilled in the art can make various changes and modifications to the above-described embodiments without departing from the technical spirit of the present invention, and such changes and modifications should fall within the protective scope of the present invention. The present invention will be described in further detail with reference to examples.
Preparation example: preparation of linseed oil microcapsule powder
(1) Weighing 80g of maltodextrin, 60g of modified starch and 30g of whey protein as wall materials, adding the wall materials into 700g of hot water with the temperature of 30-50 ℃, and stirring at high speed to completely dissolve the wall materials to form a water phase;
(2) Weighing 120g of linseed oil, gradually adding rosemary extract to 100ppm and tea polyphenol to 100ppm, and stirring to completely dissolve the linseed oil and the tea polyphenol to form an oil phase;
(3) Shearing the water phase obtained in the step (1) at a high speed at 10000-20000 rpm by using a shearing machine, slowly adding the oil phase obtained in the step 2), and keeping shearing for 10-15 min after the oil phase is completely added to obtain an emulsion;
(4) Homogenizing the emulsion obtained in the step (3) for 3 times at 30-50 ℃ by a high-pressure homogenizer, wherein the homogenizing pressure is 15-30 MPa;
(5) And (3) carrying out spray drying on the embedded and homogenized solution at the air inlet temperature of 145-160 ℃ and the air outlet temperature of 80-100 ℃ to obtain the linseed oil microcapsule powder, wherein the embedding rate is 86%.
Example 1
A soft chewable tablet for beautifying hair and protecting skin for dogs and a preparation method thereof are disclosed, wherein the soft chewable tablet comprises the following components in percentage by weight:
| linseed oil microcapsule powder | 16％ |
| EPA | 8.5％ |
| DHA | 7.5％ |
| Methionine zinc | 0.5％ |
| Vitamin E acetate | 0.2％ |
| Soybean oil | 17％ |
| Glycerol | 6％ |
| Povidone K30 | 4％ |
| Chicken liver powder | 12％ |
| Pregelatinized starch | 22.3％ |
| Cross-linked polyvidone | 5％ |
| Sodium benzoate | 0.2％ |
| Magnesium stearate | 0.8％ |
The preparation method comprises the following steps:
1) Respectively sieving solid raw and auxiliary materials such as linseed oil microcapsule powder, EPA, DHA, zinc methionine, vitamin E acetate, polyvidone K30, chicken liver powder, pregelatinized starch, crospovidone, sodium benzoate and the like through a 40-mesh sieve, and mixing uniformly at room temperature for about 20min by using a wet granulator to obtain a solid powder mixture;
2) Mixing glycerol and soybean oil at room temperature for 15min, slowly adding into the solid powder mixture, stirring, and shearing for 10min to obtain wet granule;
3) Slowly drying the wet granules in a drying box (non-circulating air, set temperature is 30 ℃) until the moisture of the wet granules is 5-10%;
4) Granulating the wet granules dried in the step 3) through a 20-mesh screen;
5) Adding magnesium stearate into the granules prepared in the step 4), uniformly mixing, and tabletting on a rotary tablet press by using a 18.3mm square punch, wherein the tablet weight is controlled to be 3.0 +/-0.15 g, and the hardness is not more than 2kg.
Example 2
A soft chewable tablet for beautifying hair and protecting skin for dogs and a preparation method thereof are disclosed, wherein the soft chewable tablet comprises the following components in percentage by weight:
the preparation method comprises the following steps:
1) Respectively sieving solid raw and auxiliary materials such as linseed oil microcapsule powder, EPA, DHA, zinc methionine, vitamin E acetate, sodium carboxymethylcellulose, beef essence, microcrystalline cellulose, sodium carboxymethyl starch, potassium sorbate and the like through a 40-mesh sieve, and mixing uniformly at room temperature for about 20min by using a wet granulator to obtain a solid powder mixture;
2) Mixing the prescribed amounts of glycerin, corn oil and water at room temperature for about 15min to homogenize, slowly adding the homogenized mixture to the solid powder mixture and continuing to stir and shear for 10min to obtain wet granules;
3) Slowly drying the wet granules in a drying box (non-circulating air, set temperature is 25 ℃) until the moisture of the wet granules is 5-10%;
4) Granulating the wet granules dried in the step 3) through a 18-mesh screen;
5) Adding colloidal silicon dioxide into the granules prepared in the step 4), uniformly mixing, and tabletting on a rotary tablet press by using a square punch with the thickness of 18.3mm by 18.3mm, wherein the tablet weight is controlled to be 3.0 +/-0.15 g, and the hardness is not more than 2kg.
Example 3
The soft chewable tablet for hair care and skin care of dogs and the preparation method thereof comprise the following components by weight percent:
| linseed oil microcapsule powder | 14％ |
| EPA | 7.5％ |
| DHA | 6.5％ |
| Zinc methionine | 0.45％ |
| Vitamin E acetate | 0.12％ |
| Soybean oil | 10％ |
| Polyethylene glycol 400 | 5％ |
| Water (I) | 3％ |
| Starch | 5％ |
| Chicken essence | 15％ |
| Mannitol | 10％ |
| Sucrose | 17.13％ |
| Cross-linked polyvidone | 5％ |
| Sodium diacetate | 0.3％ |
| Magnesium stearate | 1％ |
The preparation method comprises the following steps:
1) Respectively sieving solid raw and auxiliary materials such as linseed oil microcapsule powder, EPA, DHA, zinc methionine, vitamin E acetate, starch, chicken essence, mannitol, sucrose, crospovidone, sodium diacetate and the like with a 40-mesh sieve, and mixing uniformly at room temperature for about 20min by using a wet granulator to obtain a solid powder mixture;
2) Mixing the soybean oil, the polyethylene glycol 400 and the water according to the prescription amount at room temperature for about 15min to be uniform, slowly adding the mixture into the uniformly mixed solid powder mixture, and continuously stirring and shearing for 10min to obtain wet granules;
3) Slowly drying the wet granules in a drying box (non-circulating air, set temperature of 35 ℃) until the moisture of the wet granules is 5-10%;
4) Granulating the wet granules dried in the step 3) through a 20-mesh screen;
5) Adding magnesium stearate into the granules prepared in the step 4), uniformly mixing, and tabletting on a rotary tablet press by using a 18.3mm square punch, wherein the tablet weight is controlled to be 3.0 +/-0.15 g, and the hardness is not more than 2kg.
Example 4
The soft chewable tablet for hair care and skin care of dogs and the preparation method thereof comprise the following components by weight percent:
| linseed oil microcapsule powder | 13.5％ |
| EPA | 7％ |
| DHA | 6.25％ |
| Zinc methionine | 0.4％ |
| Vitamin E acetate | 0.1％ |
| Corn oil | 3％ |
| Glycerol | 12％ |
| Water (I) | 4％ |
| Hydroxypropyl methylcellulose | 8％ |
| Spray-dried plasma protein powder | 15％ |
| Microcrystalline cellulose | 14.05％ |
| Pregelatinized starch | 12.6％ |
| Croscarmellose sodium | 3％ |
| Calcium propionate | 0.4％ |
| Colloidal silica | 0.7％ |
The preparation method comprises the following steps:
1) Respectively sieving solid raw and auxiliary materials such as linseed oil microcapsule powder, EPA, DHA, zinc methionine, vitamin E acetate, hydroxypropyl methylcellulose, spray-dried plasma protein powder, microcrystalline cellulose, pregelatinized starch, cross-linked sodium carboxymethylcellulose, calcium propionate and the like with a 40-mesh sieve, and mixing uniformly at room temperature for about 20min by using a wet granulator to obtain a solid powder mixture;
2) Mixing corn oil, glycerol and water at room temperature for 15min, slowly adding into the solid powder mixture, and stirring and shearing for 10min to obtain wet granules;
3) Slowly drying the wet granules in a drying box (non-circulating air, set temperature of 35 ℃) until the moisture of the wet granules is 5-10%;
4) Granulating the wet granules dried in the step 3) through a 24-mesh screen;
5) Adding colloidal silicon dioxide into the granules prepared in the step 4), uniformly mixing, and tabletting on a rotary tablet press by using a square punch with the thickness of 18.3mm by 18.3mm, wherein the tablet weight is controlled to be 3.0 +/-0.15 g, and the hardness is not more than 2kg.
Test example 1: stability test
The stability test method comprises the following steps: the soft chewable tablets of the four formulations of the examples were packaged with aluminium plastic (40 tablets each) and left under accelerated conditions for 6 months (40 ℃ ± 2 ℃, relative humidity 75% ± 5%), and the stability of the soft chewable tablets was observed and tested, mainly for the following four criteria: appearance, moisture content, active ingredient content, average tablet weight;
and (3) measuring the moisture content: karl Fischer process
Alpha-linolenic acid, linoleic acid, EPA, DHA: measured by gas chromatography as specified in GB 5009.168.
Zinc: measured by flame atomic absorption spectrometry as specified in GB 5009.14.
Vitamin E: measured by gas chromatography as specified in GB/T14756.
The results are shown in tables 1 and 2 below:
table 1: stability testing of Soft chewable tablets of the formulations of examples 1 and 2
Table 2: stability testing of Soft chewable tablets of the formulations of examples 3 and 4
And (3) test results: from the results shown in tables 1 to 2, the soft chewable tablets of the four formulations of examples 1 to 4 had stable quality under accelerated conditions, no significant difference from the initial indicators of the test, stable appearance, no deterioration due to mold, no significant change in the indicators such as moisture content, effective component content, average tablet weight, etc.
Test example 2: palatability testing
The soft chew products of the four above examples were fed by selecting 50 pet dogs, with the evaluation criteria shown in table 3 and the test results shown in table 4:
table 3: palatability test evaluation criteria
Table 4: palatability test results
| Soft chew to be tested | Example 1 | Example 2 | Example 3 | Example 4 |
| Love to eat | 45 are | 45 | 43 | 46 |
| General of eating | 5 are | 3 | 4 | 2 |
| Difference between | 0 | 1 | 2 | 0 |
| Is not eaten | 0 is composed of | 1 | 1 | 2 |
| Palatability of food | 96.7％ | 94.7％ | 92.7％ | 94.7％ |
And (3) test results: from the palatability test results of table 4, the soft chewable tablets of the four formulations of examples 1-4 were well accepted by dogs and had good palatability.
Test example 3: test of effectiveness
The pet soft chewable tablets obtained in example 1 to example 4 were subjected to an effectiveness test on dogs to evaluate the effect on the skin and hair of the dogs, and the specific test process is as follows:
1. test materials
The basic dog food is a universal full-price food for all dog species in Baolu brand; the product used in the test group was a soft chewable tablet according to the invention from example 1 to example 4.
2. Test animals and groups
25 healthy and active adult golden retrievers are selected, and according to the principle that the weight and sex ratio are similar, the test is divided into 5 groups, namely test groups 1-4 and a control group, and each group comprises 5 dogs.
3. Test management
All test dogs are raised in an indoor single-cage mode,the occupied area of each dog is 2m2Epidemic prevention and disinfection of the dog house are carried out according to the conventional epidemic prevention program. The dog house keeps good ventilation, the excrement and urine is cleared up in the morning every day, the dog house is cleared up by a faucet, and the dogs are tied outside the dog house regularly every day to carry out proper movement. Before the test, the insects are repelled, and the pre-test period is 1 week, and the insects can be freely eaten and drunk. After the test formally begins, the test is fed with quantitative feed, the test is carried out by feeding the test once in the morning and evening (8 hours interval in the morning and evening), drinking water is freely carried out, and the test feeding period is 60 days. Wherein the control group dogs were fed daily basal dog food, and the test group 1 was fed daily basal dog food plus the soft chews obtained in example 1 for 2 tablets; test group 2 was fed daily with basal dog food + soft chews of 2 tablets obtained in example 2; test group 3 was fed daily basal dog food + soft chews obtained in example 3 in 2 tablets; test group 4 was fed daily basal dog food plus 2 soft chews from example 4, and the soft chews of the test group were fed 1 tablet each day, morning and evening.
4. Detecting the index
Hair: weighing the weights before and after 60 days respectively, carrying out sensory evaluation on the hand feeling strength, the softness and the brightness of dog hair after the test is finished, detecting the hair falling amount of the comb, and averaging the test results. The hand feeling strength is based on the action strength of the quilt hair on the palm when the quilt hair is touched; the brightness takes natural light as a light source and the brightness of the quilt hair as a standard; the softness is comprehensively judged according to the consistency of the appearance direction and the hand feeling of the quilt wool; the hand feeling strength, the softness and the brightness of the dog's fur are measured in 10 grades, and the larger the hand feeling strength is, the brighter and more flexible the fur is, the higher the score is.
Skin: after the test is finished, sensory evaluation is carried out on the skin of the dog, and the test result is averaged. ( 1-very dry, very coarse, very inelastic; 2-relatively dry, relatively rough, relatively inelastic; 3-smooth, fine, moist and elastic; 4-finer, more moist and more elastic; 5-very fine, very moist and very elastic. )
5. Test results
The results of the skin and hair effectiveness tests are shown in table 5:
table 5: product Performance test data for examples 1-4
| Daily increment (g) | Skin(s) | Hand feeling dynamics | Degree of compliance | Brightness of light | Amount of fallen wool (g) | |
| Example 1 | 3.1 | 4.2 | 9.4 | 9.5 | 9.6 | 1.2 |
| Example 2 | 3.0 | 4.2 | 9.3 | 9.5 | 9.4 | 1.4 |
| Example 3 | 3.1 | 4.1 | 9.2 | 9.4 | 9.5 | 1.4 |
| Example 4 | 3.1 | 4.0 | 9.2 | 9.4 | 9.5 | 1.6 |
| Control group | 2.8 | 3.0 | 7.8 | 8.1 | 8.2 | 4.0 |
The test results demonstrate that the examples of the present invention have better effects on improving canine hair and skin than the control group.
Claims (10)
1. The skin-care soft chewable tablet for the hair care of dogs comprises active ingredients, a binding agent, a wetting agent, a flavoring agent, a preservative, a disintegrating agent, a lubricant and a filler, wherein the active ingredients comprise linseed oil microcapsule powder and vitamin E acetate.
2. The soft chewable tablet of claim 1, wherein the active ingredient comprises linseed oil microcapsule powder, vitamin E acetate, and zinc methionine.
3. The soft chewable tablet of claim 1, wherein the active ingredient comprises linseed oil microcapsule powder, vitamin E acetate, zinc methionine, and DHA; preferably, the active ingredients comprise linseed oil microcapsule powder, vitamin E acetate, zinc methionine, DHA and EPA.
4. The soft chewable tablet of claim 1, wherein the soft chewable tablet consists of, by weight, 25% to 35% active ingredient, 2 to 10% binder, 15 to 30% humectant, 10 to 20% flavor, 0.2 to 1% preservative, 2 to 10% disintegrant, 0.2 to 1% lubricant, and 20 to 35% filler; preferably, the adhesive is selected from one or more of starch, hypromellose, sodium carboxymethylcellulose or polyvinylpyrrolidone; preferably, the wetting agent is selected from one or more of water, glycerol, soybean oil, corn oil or polyethylene glycol; preferably, the flavoring agent is selected from one or more of spray-dried plasma protein powder, chicken essence, beef essence or chicken liver powder; preferably, the preservative is selected from one or more of potassium sorbate, sodium benzoate, calcium propionate or sodium diacetate; preferably, the disintegrant is selected from one or more of sodium carboxymethyl starch, crospovidone, croscarmellose sodium or low-substituted hydroxypropyl cellulose; preferably, the lubricant is selected from one or more of magnesium stearate, colloidal silicon dioxide or talcum powder; preferably, the filler is selected from one or more of microcrystalline cellulose, pregelatinized starch, sucrose or mannitol.
5. The chewable tablet of claim 1, wherein the soft chewable tablet consists of 32.7% active ingredient, 4% binder, 23% humectant, 12% flavoring agent, 0.2% preservative, 5% disintegrant, 0.8% lubricant, and 22.3% filler; preferably, the soft chewable tablet consists of the following ingredients:
6. the soft chewable tablet of claim 1, wherein the soft chewable tablet consists of 25.43% active ingredient, 2% binder, 20% humectant, 12% flavoring agent, 0.2% preservative, 4% disintegrant, 1% lubricant, and 30.37% filler; preferably, the soft chewable tablet consists of the following ingredients:
7. the soft chewable tablet of claim 1, wherein the soft chewable tablet consists of 28.57% active ingredient, 5% binder, 18% humectant, 15% flavoring agent, 0.3% preservative, 5% disintegrant, 1% lubricant, and 27.13% filler; preferably, said soft chewable tablet consists of the following ingredients:
8. the soft chewable tablet of claim 1, wherein the soft chewable tablet consists of 27.25% active ingredient, 8% binder, 19% humectant, 15% flavoring agent, 0.4% preservative, 3% disintegrant, 0.7% lubricant, and 26.65% filler; preferably, the soft chewable tablet consists of the following components:
9. a process for preparing the soft chewable tablet according to claims 1 to 8, comprising the following steps:
(1) Sieving active ingredient, adhesive, flavoring agent, antiseptic, disintegrating agent and filler respectively, and mixing;
(2) Slowly adding a wetting agent into the solid mixture, and fully and uniformly mixing to obtain wet particles;
(3) Drying the wet granules prepared above at low temperature without ventilation;
(4) Sieving the dried wet granules;
(5) Adding a lubricant into the dried granules, uniformly mixing, pressing into soft chewable tablets in a tablet press, controlling the hardness, and packaging by aluminum plastic;
preferably, the step (3) is to dry the wet granules at a temperature of not more than 40 ℃ for 1 to 3 hours, and the moisture of the wet granules is controlled to be maintained between 5 and 10 percent;
preferably, the number of screens screened in step (4) is less than 40 mesh, preferably 16-24 mesh;
preferably, the step (5) controls the hardness not to exceed 2kg.
10. Use of the soft chewable tablet of claims 1 to 8 for the preparation of a medicament for ameliorating or eliminating hair discoloration, hair loss and skin disorders in pet dogs.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102550844A (en) * | 2010-12-17 | 2012-07-11 | 中国农业科学院饲料研究所 | health-care food for beautifying and brightening hair of dog |
| CN105029409A (en) * | 2015-06-24 | 2015-11-11 | 芦冰 | Flaxseed oil microcapsule powder and preparation method thereof |
| CN107432478A (en) * | 2017-07-28 | 2017-12-05 | 山东冠秀生物科技有限公司 | A kind of compound linseed oil microcapsule powder and preparation method thereof |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102550844A (en) * | 2010-12-17 | 2012-07-11 | 中国农业科学院饲料研究所 | health-care food for beautifying and brightening hair of dog |
| CN105029409A (en) * | 2015-06-24 | 2015-11-11 | 芦冰 | Flaxseed oil microcapsule powder and preparation method thereof |
| CN107432478A (en) * | 2017-07-28 | 2017-12-05 | 山东冠秀生物科技有限公司 | A kind of compound linseed oil microcapsule powder and preparation method thereof |
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