CN115232734B - Pneumatic suspension type three-dimensional microgravity biological effect simulation system and application thereof - Google Patents
Pneumatic suspension type three-dimensional microgravity biological effect simulation system and application thereof Download PDFInfo
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- CN115232734B CN115232734B CN202210997167.4A CN202210997167A CN115232734B CN 115232734 B CN115232734 B CN 115232734B CN 202210997167 A CN202210997167 A CN 202210997167A CN 115232734 B CN115232734 B CN 115232734B
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- 230000005486 microgravity Effects 0.000 title claims abstract description 24
- 238000004088 simulation Methods 0.000 title claims abstract description 21
- 239000000725 suspension Substances 0.000 title claims abstract description 18
- 230000004071 biological effect Effects 0.000 title claims abstract description 17
- 230000033001 locomotion Effects 0.000 claims abstract description 32
- 239000012472 biological sample Substances 0.000 claims abstract description 28
- 239000011159 matrix material Substances 0.000 claims abstract description 18
- 230000001105 regulatory effect Effects 0.000 claims description 12
- 230000005484 gravity Effects 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 5
- 239000013598 vector Substances 0.000 claims description 4
- 230000001737 promoting effect Effects 0.000 claims description 2
- 230000009347 mechanical transmission Effects 0.000 abstract description 4
- 239000011257 shell material Substances 0.000 description 7
- 238000010586 diagram Methods 0.000 description 6
- 238000012360 testing method Methods 0.000 description 5
- 239000012530 fluid Substances 0.000 description 4
- 238000004113 cell culture Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000007789 sealing Methods 0.000 description 3
- 230000001276 controlling effect Effects 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 239000002131 composite material Substances 0.000 description 1
- 238000011217 control strategy Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000005487 simulated microgravity Effects 0.000 description 1
- 238000009987 spinning Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/24—Gas permeable parts
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/56—Floating elements
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
- C12M27/10—Rotating vessel
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/06—Nozzles; Sprayers; Spargers; Diffusers
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
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Abstract
A pneumatic suspension type three-dimensional microgravity biological effect simulation system and application thereof. Relates to the technical field of microgravity environment simulation. The digital valve matrix type ball valve comprises a box body 1, a control system 2 and a gas source 3, and further comprises a ball bowl support 5, a digital valve matrix module 4 and a ball dish 6, wherein the ball bowl support 5 is provided with a ball socket for accommodating the ball dish 6, and the surface of the ball socket is provided with an orifice 51; the air source 3 is communicated with the throttle hole 51 through the digital valve matrix module 4 and the pneumatic pipeline 52; the air flow ejected from the throttle hole 51 blows against the spherical dish 6, so that the spherical dish 6 is suspended in the ball socket of the spherical bowl support 5 to perform random rotation movement. The invention radically eliminates redundant influence on biological sample culture and motion trail caused by mechanical transmission structure.
Description
Technical Field
The invention relates to the technical field of microgravity environment simulation, in particular to a non-contact pneumatic suspension type three-dimensional microgravity biological effect simulation system and application thereof.
Background
The microgravity biological effect simulation device is biological test equipment which is used for simulating the response of a biological sample in a microgravity environment on the ground, is not limited to the microgravity biological effect simulation research in the field of space life science, and has wide application in other cell culture tests. At present, most of the common structures are rotary bioreactors rotating around a single or double rotation axis, wherein random positioners belonging to the structure of double-shaft gyrators are most widely used.
Like "CN112675929a, name: an integrated machine and a method for providing simulated microgravity effect for biology adopt mechanical drive to fix a culture bottle in a clamp outer frame of a three-dimensional rotator, and lock the culture bottle through a rubber pad and a tightening screw handle which are oppositely arranged; the three-dimensional rotator loaded with the culture flask is magnetically fixed in a box body of the incubator through a rotating base and is powered on, and then the rotating speeds of the first driving motor and the second driving motor are set through a display control screen to simulate the microgravity environment.
However, for a random positioner, the "random" positioning motion is not truly "random", and is essentially a composite motion realized by the cooperation of motors controlling two rotating shafts through a microcomputer based on a computer random number table; in addition, for the gyrator with the mechanical transmission structure, no matter what motion rule is adopted, the biological sample in the culture dish can be inevitably influenced by vibration and stress generated during the operation of the mechanical structure in the operation process of the device, so that the motion characteristics of fluid in the culture dish and the biological sample are disturbed, and the culture growth of the biological sample in the microgravity biological effect simulation test can be additionally influenced.
Disclosure of Invention
Aiming at the technical problems, the invention provides a pneumatic suspension type three-dimensional microgravity biological effect simulation system which abandons the concept of mechanical driving, adopts a non-contact driving mode and utilizes the randomness of turbulent motion to further realize the random motion of suspension rotation and application thereof.
The technical scheme of the invention is as follows: the digital valve matrix type ball valve comprises a box body 1, a control system 2 and a gas source 3, and further comprises a ball bowl support 5, a digital valve matrix module 4 and a ball dish 6, wherein the ball bowl support 5 is provided with a ball socket for accommodating the ball dish 6, and the surface of the ball socket is provided with an orifice 51; the air source 3 is communicated with the throttle hole 51 through the digital valve matrix module 4 and the pneumatic pipeline 52; the air flow ejected from the throttle hole 51 blows against the spherical dish 6, so that the spherical dish 6 is suspended in the ball socket of the spherical bowl support 5 to perform random rotation movement.
The throttle hole 51 of the ball socket surface comprises a main hole 511, an auxiliary hole 512 and a speed regulating hole 513;
The main holes 511 are uniformly arranged at the middle positions of the bottoms of the ball sockets, and are used for suspending the spherical dish 6 relative to the spherical bowl support 5;
The auxiliary holes 512 are provided with a plurality of groups and are distributed around the main holes 511 in a crossing way, and are used for forming turbulence on the spherical surface of the spherical dish 6 and promoting the spherical dish 6 to randomly rotate;
the speed regulating holes 513 are provided with 3-4 groups and are uniformly distributed at the middle-upper part of the ball socket and used for providing pneumatic flow in random rotation directions and regulating the rotating speed.
The digital valve matrix module 4 is provided with digital valves corresponding to the main hole 511, the auxiliary hole 512 and the speed regulating hole 513 one by one, and the digital valves are connected with the control system.
The air source 3 comprises an air pressure source 31, an air pump 32 and an overflow valve 33 for supplying air to each of said digital valves.
The spherical dish 6 is formed by detachably screwing an upper hemispherical shell 61 and a lower hemispherical shell 62.
The spherical dish 6 comprises a body and a cover 63, the cover 63 is spherical crown-shaped, holes matched with the cover 63 in shape are formed in the body, and the cover 63 is connected with the holes in the body through a sealing threaded connection structure.
The distance measuring devices 7 are uniformly distributed on the opening edge of the spherical bowl support 5 and used for collecting real-time position information of the spherical dish 6, and the distance measuring devices 7 are connected with the control system 2.
And the limiting protection devices 8 are uniformly distributed on the edge of the spherical bowl support 5.
The application of the pneumatic suspension type three-dimensional microgravity biological effect simulation system in biological sample culture takes the time less than or equal to MRT as a motion period, the random motion track of the biological sample in each motion period takes the biological sample as a coordinate system, and the sum of gravity vectors applied to the biological sample in each motion period is zero.
The invention forms a stable gas flow field distribution by controlling a micro flow valve matrix in a pneumatic pipeline to directly drive a spherical culture dish, and utilizes the randomness of fluid turbulence to enable the spherical culture dish to perform suspension spin movement, so that the technical problem that a biological sample cannot generate a truly random movement track in the culture dish, which is proposed in the background art, can be solved, vibration and impact effects of a mechanical transmission structure on fluid and the biological sample in the cell culture dish in the test process can be eliminated, and redundant influences on the biological sample culture and movement track generated by the mechanical transmission structure are radically avoided.
Drawings
Figure 1 is a schematic view of the structure of the present invention,
Figure 2 is a schematic diagram of the implementation of the air-bearing effect in the present invention,
Figure 3 is a schematic diagram of the aerodynamic principle of the invention,
FIG. 4 is a schematic perspective view of a first embodiment of the spherical culture dish according to the invention,
FIG. 5 is a schematic perspective view of a second embodiment of a spherical culture dish according to the invention,
Figure 6 is a schematic diagram of the orifice layout of the inner surface of the bowl support according to the invention,
Figure 7 is a schematic structural diagram of an optimized embodiment of the present invention,
Figure 8 is a schematic diagram of the operation of the present invention,
Figure 9 is a view showing the state of the biological sample in the dish according to the present invention,
FIG. 10 is a view showing a state of a biological sample in a dish according to the present invention,
FIG. 11 is a view showing a state of a biological sample in a dish according to the present invention,
FIG. 12 is a diagram showing a biological sample according to the present invention in a dish.
In the figure 1 is a box body,
2 Is a control system, 21 is a control panel;
3 is an air source, 31 is an air pressure source, 32 is an air pump, and 33 is an overflow valve;
4 is a digital valve matrix module, and 41-49 are digital valves one-nine;
5 is a ball bowl support, 51 is an orifice, 511 is a main hole, 512 is an auxiliary hole, 513 is a speed regulating hole, and 52 is a pneumatic pipeline;
6 is a spherical dish, 61 is an upper hemispherical shell, 62 is a lower hemispherical shell, and 63 is a cover;
7 is a distance measuring device;
8 is a limit protection device;
9 is a culture solution, 91 is a cell microcarrier;
V1-9 in the figure is orifices one to nine;
in the figure, XYZ is a three-dimensional reference coordinate system, and G is the gravitational direction.
Detailed Description
The invention is further described below with reference to fig. 1-7. The invention relates to a pneumatic suspension type three-dimensional microgravity biological effect simulation system, which comprises a box body 1, a control system 2 and a gas source 3, and further comprises a ball bowl support 5, a digital valve matrix module 4 and a ball dish 6, wherein the ball bowl support 5 is provided with a ball socket for accommodating the ball dish 6, and the surface of the ball socket is provided with an orifice 51; the air source 3 is communicated with the throttle hole 51 through the digital valve matrix module 4 and the pneumatic pipeline 52; the air flow ejected from the orifice 51 blows against the bowl 6 so that the bowl 6 is suspended in the socket of the bowl support 5 for random rotational movement.
As shown in fig. 1, for the case 1 in the present invention, to facilitate the operation of the user, an integrated case structure with multiple chambers is formed, and a (microcomputer) control system 2 (including a control panel 21), an air source 3 (including a temperature control module), a digital valve matrix module 4, and an incubator module (including a bowl support 5 and a bowl 6) are integrated. For example, the box body 1 can be designed into a sealing door with a transparent observation window, the independence of the inner space is ensured, the inner wall and the outside are provided with a one-way exhaust port, an exhaust air duct, an air filtering device and an auxiliary air guide fan are arranged in the box body, and in the test, the air treatment, the recovery and the discharge can be performed in the incubator. An irradiation device can be arranged in the incubator body to provide illumination or irradiation for the inside of the incubator body. To provide cell culture requirements or to perform incubator ultraviolet sterilization.
The throttle hole 51 of the ball socket surface includes a main hole 511, an auxiliary hole 512 and a speed adjusting hole 513;
the main holes 511 are 1-5 evenly distributed at the middle position of the bottom of the ball socket and are used for suspending the spherical dish 6 relative to the spherical bowl support 5; the primary orifice 511 provides the primary high flow gas flow for the gas gap between the bowl 6 and the socket, suspending the bowl 6.
The auxiliary holes 512 are provided with a plurality of groups and are distributed around the main holes 511 in a crossing way, so that turbulence is formed on the spherical surface of the spherical dish 6, and the spherical dish 6 is driven to randomly rotate; the auxiliary throttle hole provides secondary small-flow air flow on the basis that the main throttle hole forms an air gap between the spherical culture dish and the ball socket, so that the suspension of the suspended spherical culture dish is more stable.
The speed regulating holes 513 are 3-4 groups and are uniformly distributed at the middle-upper part of the ball socket, and the speed regulating orifices provide pneumatic flow in random rotation directions and regulate the rotating speed.
The shape of the orifice 51 includes, but is not limited to, a regular pattern, such as a circle, a bar-shaped hole, a special-shaped hole, etc., and the size of the air holes is adjustable according to the spherical surface size of the hemispherical support, and the number of the air holes is at least 1.
The digital valve matrix modules 4 are provided with digital valves corresponding to the main holes 511, the auxiliary holes 512 and the speed regulating holes 513 one by one, and the digital valves are connected with a control system.
The microcomputer control system 2 controls the duty cycle of each digital valve in the matrix of digital valves 4 to adjust the air field distribution of the pneumatic lines 52 to the spherical support output to cause the spherical culture dish to perform a suspension spinning motion.
The air source 3 comprises an air pressure source 31, an air pump 32 and an overflow valve 33 for supplying air to the digital valves.
Spherical dish 6 specially designed to match spherical seat: the shell material has the function of allowing gas molecules to pass through but preventing liquid molecules from passing through; the basic shape of the appearance adopts a spherical design, including but not limited to a sphere; the bowl 6 is of non-integral design, including but not limited to two parts; spherical petri dishes and hemispherical holders of a range of sizes may be prepared according to different biological sample requirements.
There are two structural forms:
first, the bowl 6 is formed by detachably screwing an upper hemispherical shell 61 and a lower hemispherical shell 62.
Secondly, the spherical dish 6 comprises a body and a cover 63, the cover 63 is spherical crown-shaped, holes matched with the cover 63 in shape are formed in the body, and the cover 63 is connected with the holes in the body through a sealing threaded connection structure.
The distance measuring devices 7 are uniformly distributed on the opening edge of the spherical bowl support 5 and used for collecting real-time position information of the spherical dish 6, and the distance measuring devices 7 are connected with the control system 2.
And the limiting protection devices 8 are uniformly distributed on the edge of the bowl support 5.
The application of the pneumatic suspension type three-dimensional microgravity biological effect simulation system in biological sample culture is shown in fig. 8-12, wherein the time less than or equal to MRT is taken as a motion period, the random motion track of the biological sample in each motion period takes the biological sample as a coordinate system, and the sum of gravity vectors born by the biological sample in each motion period is zero.
The biological sample requires a certain time to respond to gravity, and this minimum time is called "minimum action time of gravity response", abbreviated as "Minimum Response Time (MRT)". If the time less than or equal to the MRT is taken as a movement period, the biological sample in each movement period can generate spherical random track movement, and the biological sample is taken as a coordinate system, the sum of gravity vectors born in each movement period is zero, so that the aim of simulating the microgravity biological effect is fulfilled.
It should be noted that the control system 2 of the present invention may be constituted by a microcontroller or an analog circuit, and the control strategy is the core of the unit. The outer wall of the control unit is provided with a display control screen and an operation button. In view of the arrangement and circuit configuration of the control system, the method belongs to relatively mature technical measures in the field; in addition, the adjustment of the air flow according to the quality of the actual application state of the culture dish 6 and the control of the duty ratio of each digital valve belong to the technical means of selectively setting according to the actual needs of the person skilled in the art, and are not described in detail in the present case.
The invention adopts a microcomputer control system to control a digital micro flow valve matrix to adjust the gas flow field output by the gas guide hole on the inner sphere of the hemispherical support. When the gas flow field meets the suspension condition of the spherical culture dish, the spherical culture dish is stably suspended and randomly and automatically rotated in the gas flow field by utilizing the randomness of fluid turbulence, so that a biological sample in an internal culture solution is driven to move along a spherical random track in a movement period smaller than the minimum gravity response time, and an experimental device capable of carrying out three-dimensional microgravity biological effect simulation culture on the relevant biological sample is realized.
The invention is not limited to the above embodiments, and based on the technical solution disclosed in the invention, a person skilled in the art may make some substitutions and modifications to some technical features thereof without creative effort according to the technical content disclosed, and all the substitutions and modifications are within the protection scope of the invention.
Claims (7)
1. The pneumatic suspension type three-dimensional microgravity biological effect simulation system comprises a box body (1), a control system (2) and a gas source (3), and further comprises a ball bowl support (5), a digital valve matrix module (4) and a spherical dish (6), wherein the ball bowl support (5) is provided with a ball socket for accommodating the spherical dish (6), and the surface of the ball socket is provided with an orifice (51); the air source (3) is communicated with the throttle hole (51) through the digital valve matrix module (4) and the pneumatic pipeline (52); the air flow sprayed out of the throttle hole (51) blows against the spherical dish (6) to enable the spherical dish (6) to suspend in a ball socket of the spherical bowl support (5) to do random rotation movement; it is characterized in that the method comprises the steps of,
The throttle hole (51) on the ball socket surface comprises a main hole (511), an auxiliary hole (512) and a speed regulating hole (513);
The main holes (511) are uniformly distributed at the middle positions of the bottoms of the ball sockets and are used for suspending the spherical dish (6) relative to the spherical bowl support (5);
The auxiliary holes (512) are provided with a plurality of groups and are distributed around the main holes (511) in a crossing way, and are used for forming turbulence on the spherical surface of the spherical dish (6) and promoting the spherical dish (6) to randomly rotate;
The speed regulating holes (513) are arranged in 3-4 groups and are uniformly distributed at the middle upper part of the ball socket and used for providing pneumatic flow in random rotation directions and regulating the rotating speed;
The digital valve matrix modules (4) are provided with digital valves corresponding to the main holes (511), the auxiliary holes (512) and the speed regulating holes (513) one by one, and the digital valves are connected with the control system.
2. A pneumatic suspended three-dimensional microgravity bioeffective simulation system as claimed in claim 1, wherein the gas source (3) comprises a gas pressure source (31), a gas pump (32) and an overflow valve (33) for supplying gas to each of said digital valves.
3. A pneumatic suspension three-dimensional microgravity bioeffect simulation system as claimed in claim 1, wherein the spherical dish (6) is formed by detachably screwing an upper hemispherical shell (61) and a lower hemispherical shell (62).
4. The pneumatic suspension type three-dimensional microgravity biological effect simulation system according to claim 1, wherein the spherical dish (6) comprises a body and a cover body (63), the cover body (63) is spherical crown-shaped, a hole matched with the shape of the cover body (63) is formed in the body, and the cover body (63) is connected with the hole in the body through a sealed threaded connection structure.
5. The pneumatic suspension type three-dimensional microgravity biological effect simulation system according to claim 1, wherein distance measuring devices (7) are uniformly distributed on the edge of the spherical bowl support (5) and used for collecting real-time position information of the spherical dish (6), and the distance measuring devices (7) are connected with the control system (2).
6. The pneumatic suspension type three-dimensional microgravity biological effect simulation system according to claim 1, wherein limit protection devices (8) are uniformly distributed on the edge of the spherical bowl support (5).
7. The use of a pneumatic suspended three-dimensional microgravity bioeffect simulation system according to claim 1, wherein the minimum action time of gravity response is less than or equal to the motion period, the random motion track of the biological sample in each motion period takes the biological sample itself as a coordinate system, and the sum of gravity vectors applied in each motion period is zero.
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| CN202210997167.4A CN115232734B (en) | 2022-08-19 | 2022-08-19 | Pneumatic suspension type three-dimensional microgravity biological effect simulation system and application thereof |
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