CN115192806A - Blood perfusion device - Google Patents

Abstract

The application discloses hemoperfusion ware, the novel nipple rectifier comprises a cylindrical shel, be provided with filter element group spare in the barrel, the top of barrel is provided with flexible blood bag, be provided with the flexible liquid bag with the inside intercommunication of filter element group spare in the barrel, the volume of flexible liquid bag can change under the exogenic action, the inside filter membrane subassembly that communicates with the filter element group spare that is provided with of flexible blood bag, be provided with inlet and liquid outlet on the flexible blood bag, two check valves that the equidirectional setting was seted up respectively are seted up to filter membrane subassembly's both sides, the inside separator that is provided with of blood bag, form backflow channel between separator and the filter membrane subassembly, and with blood bag internal partitioning for first inner chamber and second inner chamber, blood gets into behind the first inner chamber through the inlet, flow into in the barrel from a check valve, blood flows to behind the second inner chamber from another check valve after filter membrane subassembly and filter element group spare filter, partial blood flows out from the liquid outlet, partial blood can flow back to first inner chamber through backflow channel.

Description

Blood perfusion device

Technical Field

The application relates to the technical field of medical equipment, in particular to a blood perfusion device.

Background

The existing hemoperfusion apparatus is mainly a bulk filling filter using coated activated carbon or neutral macroporous resin as filler, and the technical improvements of the existing hemoperfusion apparatus are mainly on a coating process, resin improvement, sealing and filling structure. The prior art fails to solve the problems that the filter material in the filter element is easy to coagulate blood when directly contacting with blood, and the abrasion is caused by mutual friction and extrusion of the coated active carbon or macroporous resin in transportation. And because the filling amount of the filler is set when the filler leaves a factory, the performance of the filler is divided according to the factory model and the filling amount, and the performance cannot be continuously adjustable. And due to technical limitation, the size of the used filler is relatively large, and the dynamic performance on mass transfer is relatively common. And in use, manpower is needed to participate in repeated flapping and exhausting, particles are flushed out, the whole process is observed, and the operation requirement is high in use.

Disclosure of Invention

In view of the above, the present application discloses a hemoperfusion cartridge to overcome or at least partially address the above-mentioned problems.

The technical scheme adopted by the application is as follows: the utility model provides a blood perfusion ware, the novel nipple rectifier comprises a cylindrical shel, be provided with filter element group spare in the barrel, the top of barrel is provided with flexible blood bag, be provided with flexible liquid bag in the barrel, the inside and the inside intercommunication of filter element group spare of flexible liquid bag, the volume of flexible liquid bag can change under the exogenic action, the inside filter membrane subassembly that is provided with of flexible blood bag, the inside and the inside intercommunication of filter element group spare of filter membrane subassembly, be provided with inlet and liquid outlet on the flexible blood bag, two check valves that the equidirectional setting was seted up respectively to the both sides of filter membrane subassembly, the inside separator that is provided with of blood bag, the one end and the blood bag sealing connection of separator, form backflow channel between the other end of separator and the filter membrane subassembly, separator and filter membrane subassembly are first inner chamber and second inner chamber with the blood bag internal partitioning, blood gets into after the first inner chamber through the inlet, flow into in the barrel from a check valve, blood flows into after filter element group spare and filter element group spare flow to the second inner chamber from another check valve, partial blood flows out from the liquid outlet, partial blood can flow back to first inner chamber through backflow channel.

Preferably, the filter membrane subassembly still includes membrane silk and shell, and two check valves open and locate on the shell, and the membrane silk is installed between two check valves and is located the top of filter element group spare, and the membrane silk is arranged in separating plasma and the blood cell in the blood.

Preferably, the separator is a heat-seal line

Preferably, the barrel is inside to be separated the chamber and separate the chamber down including last, and filter element group spare sets up in last separated the chamber, and flexible liquid bag sets up in separating the chamber down, has seted up the drive bore on separating the chamber down, and the drive bore is used for connecting air pump or syringe pump.

Preferably, the filter element assembly comprises a filter element forming body and a filter membrane covering the periphery of the filter element forming body, a plasma channel is formed in the filter element forming body in a hollow mode, and the plasma channel is communicated with the flexible liquid bag.

Preferably, the filter element forming body is in the shape of a hollow cylinder, and the filter membrane is wrapped and covered on the outer wall of the hollow cylinder.

Preferably, the baffle is arranged between the upper separation cavity and the lower separation cavity, the baffle is connected with the outer wall of the barrel in a sealing manner, the connecting pipe is arranged on the baffle, the flexible liquid bag is connected to the lower end of the connecting pipe in a sealing manner, and the plasma channel is communicated with the flexible liquid bag through the connecting pipe.

Preferably, the top of the filter element assembly is provided with a sealing clapboard for sealing the filter element forming body and the plasma channel, a circulation gap exists between the sealing clapboard and the top cover of the upper separation cavity, and blood can flow to the filter element assembly through the circulation gap.

Preferably, the pore diameter of the membrane thread is 0.04-0.4 μm, the thickness of the membrane thread is 30-300 μm, the pore diameter of the filtering membrane is 1-10 μm, and the thickness of the filtering membrane is 60-600 μm.

Preferably, the filter element forming body comprises at least one material of activated carbon and adsorption resin with the particle size of 20-200 μm, and is formed by bonding fibers.

The application has the advantages that: the effective volume of the lower separate cavity is changed by expanding or compressing the effective volume of the flexible liquid bag, and plasma is filtered from blood and enters the filter element forming body for plasma adsorption by taking the effective volume as a driving force, and then the plasma is forced to enter the blood again; under the effect of the reciprocating flow, the effective flux of blood penetrating through the filter element forming body is changed, so that the performance of the filter element forming body is improved.

The flexible blood bag can buffer the pulsation of blood under the action of the reciprocating flow, protect the venous vessels of patients and reduce the mixing ratio, thereby improving the filtering efficiency under the action of the reciprocating flow.

When the equipment runs, blood enters the filter element assembly through the filter membrane assembly, so that blood cells cannot directly contact the adsorbent in the filter element assembly, and the safety performance is better; when the effective volume of the flexible fluid bag does not change, little blood passively enters the filter element assembly, so that the problem of desorption is difficult to generate even if the perfusion device is not taken down for a long time.

The particle size of the adsorbent which can be selected by the filter element forming body is greatly widened, and the powder adsorbent can be safely used, so that the selection range of the adsorbent is widened. Compared with the existing bulk-filling filter material adsorbent, the invention effectively reduces the requirements of dust generation and coating, thereby reducing the manufacturing cost; moreover, the liquid in the flexible liquid bag is not exchanged with the fluid in the lower partition cavity, so that the safety is realized; in addition, the fiber bonding filter element is selected as a filter element forming body instead of extruding or sintering activated carbon, so that the problem caused by plastic particles entering blood can be remarkably reduced.

When washing, because structural feature can need not the manpower to pat and observe and can get rid of bubble and granule. The device is characterized in that the perfusion device is arranged rightly, the liquid inlet is connected into flushing liquid, the driving hole is opened and then connected into an air pump or an injection pump, the air pump or the injection pump is started, the air pump or the injection pump reciprocates to enable the flexible filter bag to be compressed and expanded continuously, the flushing liquid is forced to enter and exit the filter element forming body for multiple times, the flushing liquid is discharged from the liquid outlet, in the process, the liquid descends to be gas and rises, the liquid enters the filter element forming body and then enters the flexible filter bag, the gas is discharged from the filter element forming body, the injection pump can automatically discharge the gas completely for multiple times, and exhaust and flushing particles do not need to be flapped repeatedly. After flushing, the perfusion device can be inverted, and similarly, the perfusion device can play a role in removing bubbles in the pipeline.

Drawings

Various other advantages and benefits will become apparent to those of ordinary skill in the art upon reading the following detailed description of the preferred embodiments. The drawings are only for purposes of illustrating the preferred embodiments and are not to be construed as limiting the invention. Also, like reference numerals are used to refer to like parts throughout the drawings. In the drawings:

FIG. 1 is a schematic view of the blood perfusion apparatus of the present application;

fig. 2-3 are schematic views of the blood flow during the actual application of the present application.

In the figure: s, a cylinder body; s1, top cover; f, the blood flowing direction; 1, a liquid inlet; 2 a liquid outlet; 3, a filter element assembly; 31 a filter element molding; 32 a filtration membrane; 33 a plasma channel; 34 sealing the partition plate; 4 an upper compartment; 5 a lower compartment; 51 a flexible liquid sac; 6, a baffle plate; 61 connecting pipes; 7 a drive hole; 8 a flow-through gap; 9 blood bag; 91 a filter membrane module; 911 membrane yarn; 912, a one-way valve; 913 an outer shell; 92 a separator; 93 a return channel; 101 a first lumen; 102 a second lumen.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention will be clearly and completely described below with reference to the specific embodiments of the present invention and the accompanying drawings. It is to be understood that the described embodiments are merely exemplary of the invention, and not restrictive of the full scope of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

The technical solutions provided by the embodiments of the present application are described in detail below with reference to the accompanying drawings. Referring to fig. 1, the blood perfusion apparatus of this embodiment, including barrel S, be provided with filter element assembly 3 in the barrel S, the top of barrel S is provided with flexible blood bag 9, be provided with flexible liquid bag 51 in the barrel S, the inside and filter element assembly 3 inside intercommunication of flexible liquid bag 51, the volume of flexible liquid bag 51 can change under the effect of external force, the inside filter membrane assembly 91 that is provided with of flexible blood bag 9, the inside and filter element assembly 3 inside intercommunication of filter membrane assembly 91, be provided with inlet 1 and liquid outlet 2 on the flexible blood bag 9, two check valves 912 that the equidirectional setting was seted up respectively to the both sides of filter membrane assembly 91, the inside separator 92 that is provided with of blood bag 9, the one end and the blood bag 9 sealing connection of separator 92, the other end and filter membrane assembly 91 position of separator 92 are close to, and form backflow channel 93 between filter membrane assembly 91, separator 92 and filter membrane assembly 91 separate the blood bag inside into first inner chamber 101 and second inner chamber 102, refer to blood circulation direction F of fig. 2 and 3, blood flows into first inner chamber 101 after entering first inner chamber 912 from one-way valve, blood backflow channel flows into from filter membrane assembly 91 and filter membrane assembly 2 again, blood backflow channel flow out, blood backflow channel flow into second inner chamber 2 can all be from inlet 2, the effect of filter membrane assembly is the blood backflow that the backflow channel is realized from inlet 2 again, blood backflow channel backflow that the backflow channel 2 again, blood flows back into, blood flows into, blood backflow channel 2 again, blood flows into, blood backflow channel 2 is from filter membrane assembly is from filter element assembly is also can be from inlet 2, the filter element assembly 2 again, blood backflow channel 2, the filter element assembly is the filter element assembly that the effect is not. The effective flow that blood passes through filter element group spare 3 and filter membrane subassembly 91 is controlled to the frequency of this embodiment accessible external force adjustment flexible liquid bag 51 volume change, and in the actual operation, let blood filtration rate be slightly faster than blood inlet speed, the blood liquid level of first inner chamber 101 just is less than the liquid level of second inner chamber 102 like this, can not appear blood and directly pass through return channel 93 bypass to liquid outlet 2 behind the entering inlet 1 to control blood purification efficiency.

In a preferred embodiment, the filter membrane assembly 91 is connected with the top cover S1 of the cylinder S in a sealing manner, besides the two one-way valves 912, the filter membrane assembly 91 further comprises membrane wires 911 and a housing 913, the two one-way valves 912 are disposed on the housing 913, the membrane wires 911 are disposed between the two one-way valves 912 and on the top of the filter element assembly 3, the membrane wires 911 are used for separating the plasma and the blood cells in the blood, so that only the plasma enters the cylinder S, the blood cells cannot enter the cylinder S and directly contact the adsorbent in the filter element assembly, and the safety performance is better, in this embodiment, the pore diameter of the membrane wires can be set to be 0.04-0.4 μm, and the thickness of the membrane wires can be set to be 30-300 μm. The one-way valve is arranged to perform a one-way conduction function, so that blood is allowed to flow into the filter membrane assembly 91 from the first inner cavity 101 in one way, filtered and then flows out of the second inner cavity 102 through the other one-way valve 912, and the filtered blood is prevented from returning to the first inner cavity from the inside of the filter membrane assembly again, and the filtering efficiency is reduced.

In a preferred embodiment, the cartridge S comprises an upper compartment 4 and a lower compartment 5 inside, the filter element assembly 3 is disposed in the upper compartment 4, the flexible sac 51 is disposed in the lower compartment 5, and the lower compartment 5 is formed with a driving hole 7, and the driving hole 7 is used for connecting an air pump or an injection pump. The volume of lower compartment 5 can be occupied by filling gas or liquid along drive hole 7 using a gas or syringe pump, thereby compressing flexible bag 51, allowing the liquid in flexible bag 51 to pass through filter cartridge assembly 3 into upper compartment 4; conversely, the use of a gas or syringe pump to draw gas or liquid from lower compartment 5 along drive aperture 7 allows liquid in upper compartment 4 to permeate filter element assembly 3 and re-enter flexible fluid bladder 51. Filling or withdrawing fluid from drive aperture 7 may provide motive force to move liquid in upper compartment 4 into or out of filter cartridge assembly 3. The effective flux of blood penetrating through the filter element assembly 3 can be influenced by changing the running frequency and the stroke of the air pump or the injection pump, and the performance of blood filtration is improved.

In one embodiment of the present application, the filter element assembly 3 includes a filter element forming body 31 and a filter membrane 32 wrapped around the filter element forming body 31, a plasma channel 33 is hollowed inside the filter element forming body 31, and the plasma channel 33 is communicated with the flexible liquid bag 51. Preferably, the filter element shaped body 31 is designed as a hollow cylinder, and the filter membrane 32 is coated on the outer wall of the hollow cylinder. In this embodiment, the blood is forced to enter the filter element forming body 31 through the filter membrane 32, and because of the blocking effect of the filter membrane, the blood cells in the blood do not directly contact the adsorbent in the filter element forming body 31, so that the safety performance is better. In this embodiment, the aperture of the filtering membrane can be designed to be 1 μm to 10 μm, and the thickness of the filtering membrane can be set to be 60 μm to 600 μm; the adsorbent in the filter element forming body 31 comprises at least one material of activated carbon with the grain diameter of 20-200 μm and adsorption resin, and is formed by bonding fibers, and the fiber bonding filter element is selected as the filter element forming body 31 instead of extruding or sintering the activated carbon, so that the problem caused by plastic particles entering blood can be remarkably reduced. The particle size of the adsorbent which can be selected by the filter element forming body 31 is greatly widened, and the powder adsorbent can be safely used, so that the selection range of the adsorbent is widened. Compared with the bulk filler with large particle size, the formed body prepared by the adsorption material with fine particle size has much better mass transfer performance, and compared with the existing bulk filler adsorbent, the formed body effectively reduces the requirements of dust generation and coating, so that the manufacturing cost is reduced. The liquid in flexible bag 51 is not exchanged with the fluid in lower compartment 5, which provides a high safety.

In one embodiment of the present application, a baffle 6 is disposed between the upper compartment 4 and the lower compartment 5, the baffle 6 is hermetically connected to the outer wall of the barrel S, a connection tube 61 is disposed on the baffle 6, and the plasma channel 33 is communicated with the flexible liquid bag 51 through the connection tube 61. Further, a flexible liquid bladder 51 is hermetically connected to the lower end of the connection pipe 61. The outer side of the flexible liquid bag 51 is hermetically arranged between the lower separating chamber 5 and the baffle 6, and when the driving hole 7 is externally connected with an air pump, the influence of air pressure on the volume change of the flexible liquid bag 51 can be better controlled.

In one embodiment of the present application, the top of the cartridge module 3 is provided with a sealing barrier 34 for covering the cartridge molding 31 and the plasma channel 33, the sealing barrier 34 serving to prevent blood from passing through the cartridge module 3 but directly into and out of the flexible bladder 51 from the plasma channel 33.

In one embodiment of the application, a flow gap 8 exists between the sealing partition 34 at the top of the filter cartridge assembly and the top cover S1 of the upper compartment 4, through which flow gap 8 blood can flow to the filter membrane assembly 91.

While the foregoing is directed to embodiments of the present invention, other modifications and variations of the present invention may be devised by those skilled in the art in light of the foregoing teachings. It should be understood by those skilled in the art that the foregoing detailed description is for the purpose of better explaining the present invention, and the scope of the present invention should be determined by the scope of the appended claims.

Claims (10)

1. The utility model provides a blood perfusion ware, includes the barrel, its characterized in that, be provided with filter element group spare in the barrel, the top of barrel is provided with flexible blood bag, be provided with flexible liquid bag in the barrel, flexible liquid bag inside with the inside intercommunication of filter element group spare, the volume of flexible liquid bag can change under the exogenic action, the inside filter membrane subassembly that is provided with of flexible blood bag, filter membrane subassembly inside with the inside intercommunication of filter element group spare, be provided with inlet and liquid outlet on the flexible blood bag, two check valves that the equidirectional setting was seted up respectively to filter membrane subassembly's both sides, the inside separator that is provided with of blood bag, the one end of separator with blood bag sealing connection, the other end of separator with form backflow channel between the filter membrane subassembly, the separator with the filter membrane subassembly will blood bag internal partitioning is first inner chamber and second inner chamber, and blood warp the inlet gets into behind the first inner chamber, flow into from one the check valve in the barrel, blood warp the filter membrane subassembly with after the filter element group spare filters from another flow to behind the second inner chamber, partial blood liquid outlet flows, partial blood can flow back to first inner chamber backward flow to first inner chamber.

2. The hemoperfusion cartridge of claim 1 wherein the filter membrane assembly is sealingly connected to the top cap of the cartridge body, the filter membrane assembly further comprising a membrane wire and a housing, the two one-way valves being open on the housing, the membrane wire being mounted between the two one-way valves and on top of the filter element assembly, the membrane wire being for separating plasma from blood cells in the blood.

3. The hemoperfusion cartridge of claim 1 wherein the partition is a heat seal wire.

4. The hemoperfusion cartridge of claim 2 wherein the cartridge includes an upper compartment and a lower compartment, the filter element assembly is disposed in the upper compartment, the flexible bag is disposed in the lower compartment, and the lower compartment has a drive port for connection to an air pump or an injection pump.

5. The hemoperfusion cartridge of claim 4 wherein the filter cartridge assembly comprises a filter cartridge moulded body and a filter membrane covering the periphery of the filter cartridge moulded body, the filter cartridge moulded body is hollowed out to form a plasma channel, and the plasma channel is communicated with the flexible liquid bag.

6. The hemoperfusion cartridge of claim 5 wherein the filter element molding is in the shape of a hollow cylinder and the filter membrane is wrapped over the outer wall of the hollow cylinder.

7. The hemoperfusion cartridge of claim 5 wherein a baffle is disposed between the upper compartment and the lower compartment, the baffle is sealingly connected to the outer wall of the barrel, a connection tube is disposed on the baffle, the flexible sac is sealingly connected to the lower end of the connection tube, and the plasma passageway is in communication with the flexible sac through the connection tube.

8. The hemoperfusion cartridge of claim 5 wherein a sealing septum is provided on the top of said filter cartridge assembly for sealing over said filter cartridge molding and said plasma passageway, a flow gap being provided between said sealing septum and the top cover of said upper compartment through which blood can flow to said filter membrane assembly.

9. The hemoperfusion cartridge of any of claims 5 to 8 wherein the membrane filaments have a pore size of 0.04 to 0.4 μm, the membrane filaments have a thickness of 30 to 300 μm, the filtration membrane has a pore size of 1 to 10 μm, and the filtration membrane has a thickness of 60 to 600 μm.

10. The hemoperfusion cartridge of any of claims 5-8 wherein the cartridge molding comprises at least one of activated carbon having a particle size of 20 μm to 200 μm, and an adsorbent resin, and is adhesively molded using fibers.

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