CN115192652B - Universal granule and preparation method thereof - Google Patents
Universal granule and preparation method thereof Download PDFInfo
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- CN115192652B CN115192652B CN202111019115.1A CN202111019115A CN115192652B CN 115192652 B CN115192652 B CN 115192652B CN 202111019115 A CN202111019115 A CN 202111019115A CN 115192652 B CN115192652 B CN 115192652B
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- 239000008187 granular material Substances 0.000 title claims abstract description 33
- 238000002360 preparation method Methods 0.000 title claims abstract description 24
- 239000000843 powder Substances 0.000 claims abstract description 69
- 239000002245 particle Substances 0.000 claims abstract description 62
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 claims abstract description 31
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 31
- 235000006226 Areca catechu Nutrition 0.000 claims abstract description 29
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 28
- 244000080767 Areca catechu Species 0.000 claims abstract description 28
- 238000000338 in vitro Methods 0.000 claims abstract description 28
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 94
- 238000002156 mixing Methods 0.000 claims description 48
- 239000000203 mixture Substances 0.000 claims description 48
- 239000007864 aqueous solution Substances 0.000 claims description 26
- 239000007788 liquid Substances 0.000 claims description 26
- 206010004542 Bezoar Diseases 0.000 claims description 24
- 125000003118 aryl group Chemical group 0.000 claims description 23
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 claims description 22
- JHGWQSGWUPCKNT-UHFFFAOYSA-N 2-tert-butyl-4-methyl-1,3,5-trinitrobenzene Chemical compound CC1=C([N+]([O-])=O)C=C([N+]([O-])=O)C(C(C)(C)C)=C1[N+]([O-])=O JHGWQSGWUPCKNT-UHFFFAOYSA-N 0.000 claims description 22
- 229940116229 borneol Drugs 0.000 claims description 22
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 claims description 22
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 claims description 22
- 239000011812 mixed powder Substances 0.000 claims description 22
- 238000012216 screening Methods 0.000 claims description 22
- 238000001035 drying Methods 0.000 claims description 21
- 241000037740 Coptis chinensis Species 0.000 claims description 18
- 239000008213 purified water Substances 0.000 claims description 18
- 229910001220 stainless steel Inorganic materials 0.000 claims description 16
- 239000010935 stainless steel Substances 0.000 claims description 16
- 238000000227 grinding Methods 0.000 claims description 14
- 238000009835 boiling Methods 0.000 claims description 12
- 239000002994 raw material Substances 0.000 claims description 11
- 238000003756 stirring Methods 0.000 claims description 11
- 238000001914 filtration Methods 0.000 claims description 7
- 238000004806 packaging method and process Methods 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 4
- 230000000694 effects Effects 0.000 abstract description 7
- 244000153234 Hibiscus abelmoschus Species 0.000 abstract description 6
- -1 XIANGHOU Chemical compound 0.000 abstract description 6
- 238000005516 engineering process Methods 0.000 abstract description 6
- BJRNKVDFDLYUGJ-RMPHRYRLSA-N hydroquinone O-beta-D-glucopyranoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-RMPHRYRLSA-N 0.000 abstract description 6
- 206010010904 Convulsion Diseases 0.000 abstract description 5
- 230000036461 convulsion Effects 0.000 abstract description 5
- 238000003860 storage Methods 0.000 abstract description 5
- 238000010521 absorption reaction Methods 0.000 abstract description 3
- 230000007774 longterm Effects 0.000 abstract description 3
- 206010013954 Dysphoria Diseases 0.000 abstract description 2
- 206010068319 Oropharyngeal pain Diseases 0.000 abstract description 2
- 206010034829 Pharyngeal oedema Diseases 0.000 abstract description 2
- 230000008859 change Effects 0.000 abstract description 2
- 238000001784 detoxification Methods 0.000 abstract description 2
- 206010018388 glossodynia Diseases 0.000 abstract description 2
- 208000018962 mouth sore Diseases 0.000 abstract description 2
- 208000023409 throat pain Diseases 0.000 abstract description 2
- 239000002775 capsule Substances 0.000 description 14
- 238000007873 sieving Methods 0.000 description 12
- 238000012360 testing method Methods 0.000 description 10
- 239000003814 drug Substances 0.000 description 8
- 238000004519 manufacturing process Methods 0.000 description 7
- 241000283973 Oryctolagus cuniculus Species 0.000 description 6
- 239000000080 wetting agent Substances 0.000 description 6
- 241000283690 Bos taurus Species 0.000 description 4
- 229930006000 Sucrose Natural products 0.000 description 4
- 238000012545 processing Methods 0.000 description 4
- 239000005720 sucrose Substances 0.000 description 4
- 125000000185 sucrose group Chemical group 0.000 description 4
- 238000005303 weighing Methods 0.000 description 4
- 210000000941 bile Anatomy 0.000 description 3
- 239000006185 dispersion Substances 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 241001483116 Neopicrorhiza scrophulariiflora Species 0.000 description 2
- 230000036760 body temperature Effects 0.000 description 2
- ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 description 2
- 235000005487 catechin Nutrition 0.000 description 2
- 229950001002 cianidanol Drugs 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 230000002349 favourable effect Effects 0.000 description 2
- 238000011049 filling Methods 0.000 description 2
- 238000005469 granulation Methods 0.000 description 2
- 230000003179 granulation Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 235000011837 pasties Nutrition 0.000 description 2
- 244000235603 Acacia catechu Species 0.000 description 1
- 208000037386 Typhoid Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 238000005054 agglomeration Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 210000005069 ears Anatomy 0.000 description 1
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000007721 medicinal effect Effects 0.000 description 1
- 238000007781 pre-processing Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 201000008297 typhoid fever Diseases 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/413—Gall bladder; Bile
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/55—Glands not provided for in groups A61K35/22 - A61K35/545, e.g. thyroids, parathyroids or pineal glands
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- A61K36/13—Coniferophyta (gymnosperms)
- A61K36/15—Pinaceae (Pine family), e.g. pine or cedar
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
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Abstract
The invention relates to the technical field of A61K35/00, in particular to a Wanzhen granule and a preparation method thereof; the preparation method of the universal granule comprises the following steps: rhizoma Coptidis, rhizoma picrorhizae, catechu, XIANGHOU, borneolum Syntheticum, fel Ursi powder, artificial Moschus, and in vitro cultured calculus bovis and fel bovis seu Bubali; the wanying particles prepared by the technology have good heat clearing effect, and simultaneously have the functions of detoxification and convulsion relieving, and particularly have good treatment effect on the state with gum, throat swelling and pain and dysphoria and easy convulsion, and particularly relieve the problem of mouth and tongue sore caused by high heat in the high heat state; the universal particles prepared by the technology have good stability, low water absorption change rate and high long-term storage stability.
Description
Technical Field
The invention relates to the technical field of A61K35/00, in particular to a Wanzhen granule and a preparation method thereof.
Background
The Chinese patent nanometer Wan Ying spindle preparation medicine with patent application number CN01100252.2 and the preparation method thereof disclose that nanometer coptis chinensis, nanometer rhizoma picrorhizae, nanometer Catechu and nanometer aromatic ink are adopted to prepare traditional Chinese medicine decoction pieces, no auxiliary materials are added in the preparation process, and no data of the action effect of the medicine are given.
The Chinese patent with the patent application number of CN201710643567.4 discloses a preparation method of a compound traditional Chinese medicine granule, which adopts the processing modes of extract preparation, embedding agent preparation, low-temperature boiling granulation, granule embedding and high-temperature boiling drying to prepare the traditional Chinese medicine granule, solves the technical problems of preparing the compound traditional Chinese medicine granule by low-temperature boiling granulation and embedding the granule, but does not disclose the problems of granule stability and storage stability which need to be overcome when the traditional Chinese medicine granule is prepared by preprocessing the traditional Chinese medicine with ethanol.
Therefore, solving the problems of particle stability and storage stability that need to be overcome in the process of preparing pharmaceutical particles is a major technical problem that needs to be solved at present.
Disclosure of Invention
In order to solve the problems, the invention provides a universal granule, which is prepared from the following raw materials: rhizoma Coptidis, rhizoma picrorhizae, catechu, XIANGHOU, borneolum Syntheticum, fel Ursi powder, artificial Moschus, and in vitro cultured calculus bovis and fel bovis seu Bubali.
Preferably, the universal particles are prepared from the following raw materials in parts by weight: 50-65 parts of coptis chinensis, 50-65 parts of rhizoma picrorhizae, 50-65 parts of catechu, 105-125 parts of aromatic ink, 3-4 parts of borneol, 10.2-12 parts of bear gall powder, 2-3.5 parts of artificial musk, 2-3.5 parts of in-vitro cultured bezoar and 80-98 parts of ox gall.
Preferably, the particle size of the in vitro cultured bezoar is 170-190 μm.
Further, the particle size of the in vitro cultured bezoar is 175 μm.
The coptis chinensis, rhizoma picrorhizae, catechu, aromatic ink, borneol, bear gall powder, artificial musk, in-vitro cultured bezoar and ox bile adopted in the invention are obtained through commercial purchase.
The preparation method of the all-purpose granule comprises the following steps:
s1, crushing rhizoma picrorhizae, coptis chinensis, catechu and aromatic ink to form mixed powder;
s2, mixing the in-vitro cultured bezoar with the mixed powder in the S1 to obtain a mixture a;
s3, adding a proper amount of purified water into bear gall powder, boiling and dissolving to obtain bear gall powder liquid;
s4, concentrating and filtering the oxgall to obtain oxgall paste;
s5, adding a proper amount of purified water into the ox gall paste and the bear gall powder liquid, and stirring and mixing to obtain a mixture b;
s6, adding sugar powder into the mixture a, uniformly mixing, adding the mixture into the mixture b, adding an aqueous solution containing ethanol, stirring, granulating, drying, granulating and screening;
s7, grinding borneol and artificial musk, uniformly mixing with the particles subjected to the screening in the S6, and sub-packaging to obtain the Wanzi particles.
And in the step S3, adding bear gall powder into purified water, boiling and dissolving to obtain bear gall powder liquid, and continuously stirring to obtain liquid pasty bear gall powder liquid.
Preferably, in the step S1, the rhizoma picrorhizae, the coptis chinensis, the catechu and the aromatic ink are crushed to form mixed powder with the particle size of 170-190 mu m.
Further, in the step S1, the rhizoma picrorhizae, the coptis chinensis, the catechu and the aromatic ink are crushed to form mixed powder with the particle size of 175 mu m.
The applicant has found in experiments that when the weight ratio of coptis chinensis to picrorhiza rhizome to catechin to ink is 1 (0.9-1.1) (1.9-2), especially the weight ratio of coptis chinensis to picrorhiza rhizome to catechin to ink is 1:1:1:2, the processing stability and the medicinal effect of the prepared universal particles are good, and the influence of high heat on the body can be effectively reduced; when the bezoar cultured in vitro is 170-190 mu m, especially when the particle size is 175 mu m, the bezoar is mixed with sugar powder and mixed powder formed by coptis chinensis, rhizoma picrorhizae, catechu and aromatic ink, the bezoar can be uniformly dispersed in the mixture a, and the dispersion uniformity of each raw material in the universal particles is improved.
Preferably, the grain size of the sugar powder in the S2 is 160-180 μm, and the sugar powder is sucrose powder.
Further, the particle size of the sugar powder in S2 is 170 μm.
Preferably, the water amount in the S3 is 1-2 times of the weight of the bear gall powder.
Further, the water quantity in the S3 is 1.4-1.6 times of the weight of the bear gall powder.
Further, the water quantity in the S3 is 1.5 times of the weight of the bear gall powder. Preferably, the volume fraction of ethanol in the aqueous solution containing ethanol in S5 is 95%.
The adding amount of the purified water in the step S5 is determined according to the state that the cattle gall paste and the bear gall powder liquid can be prepared into a wetting agent in actual production.
Preferably, the volume fraction of ethanol added to the aqueous solution containing ethanol in S6 is 70% -95%.
Preferably, the volume fraction of ethanol added to the aqueous solution containing ethanol in S6 is 80% -95%.
The applicant found in experiments that, when the volume fraction of ethanol in the aqueous solution containing ethanol is 80% -95%, especially when the volume fraction of ethanol is 80% or 95%, the processing stability of the universal particles can be improved, probably because the functional groups contained in the ethanol can form good interaction force between the components, the dispersion stability of the raw material components during mixing is improved, the water absorption is reduced, and the long-term storage stability of the universal particles is also improved.
Preferably, the temperature of the drying in the step S6 is 45-60 ℃.
Further, the drying temperature in the step S6 is 50-60 ℃.
Further, the drying temperature in S6 is 50 ℃, 51 ℃, 52 ℃, 53 ℃, 54 ℃, 55 ℃, 56 ℃, 57 ℃, 58 ℃, 59 ℃ and 60 ℃.
Preferably, the mixing in S2 is performed for a period of 10-20min.
Preferably, the time for mixing the mixture a and the mixture b in the step S6 is 10-20min.
Preferably, the finishing in the step S6 is carried out by arranging a 5-20 mesh stainless steel screen through a swinging granulator.
And (3) further, finishing the grains in the step S6, namely, installing a 10-mesh stainless steel screen for finishing the grains through a swinging type granulator.
Preferably, the screening in the step S6 is carried out by arranging a stainless steel screen with 5-20 meshes and 70-90 meshes through a swinging type granulator.
And further, the S6 screening is carried out by installing a 10-mesh and 80-mesh stainless steel screen mesh on a swing type granulator.
Preferably, in the step S7, borneol and artificial musk are ground, sieved by a 50-70 mesh sieve, and then are uniformly mixed with the particles subjected to the sieving in the step S6.
Preferably, in the step S7, the borneol and the artificial musk are ground, sieved by a 60-mesh sieve, and then are uniformly mixed with the particles subjected to the sieving in the step S6.
Preferably, the universal granules with the weight of 1g per bag are prepared after the split charging in the step S7.
The applicant has found in experiments that the grinding of borneol and artificial musk is favorable for mixing and dispersing with other components, but the grinding particle size is too small, agglomeration can be easily generated, and uniform dispersion among the components is not favorable.
The preparation method of the all-purpose capsule comprises the following steps:
s1, crushing rhizoma picrorhizae, coptis chinensis, catechu and aromatic ink to form mixed powder;
s2, mixing the in-vitro cultured bezoar with the mixed powder in the S1 to obtain a mixture A;
s3, adding a proper amount of purified water into bear gall powder, boiling and dissolving to obtain bear gall powder liquid;
s4, concentrating and filtering the oxgall to obtain oxgall paste;
s5, adding an ethanol aqueous solution containing ethanol into the ox gall paste and bear gall powder liquid to mix to obtain a mixture B;
s6, mixing the mixture A and the mixture B, adding an ethanol aqueous solution containing ethanol, stirring, granulating by a granulator, drying, granulating, and screening;
s7, grinding borneol and artificial musk, uniformly mixing with the particles subjected to the screening in the S6 to obtain mixed particles, and filling the mixed particles into hollow capsules to obtain the Wan Ying capsules.
Preferably, in the step S1, the rhizoma picrorhizae, the coptis chinensis, the catechu and the aromatic ink are crushed to form mixed powder with the particle size of 175 μm.
And in the step S3, adding bear gall powder into purified water, boiling and dissolving to obtain bear gall powder liquid, and continuously stirring to obtain liquid pasty bear gall powder liquid.
Preferably, the volume fraction of ethanol in the ethanol aqueous solution in S5 is 95%.
The addition amount of the aqueous solution containing ethanol in the step S5 is proper and is determined according to the state that the ox gall paste and the bear gall powder liquid can be prepared into a wetting agent in actual production.
Preferably, the volume fraction of ethanol added to the aqueous solution containing ethanol in S6 is 95%.
Preferably, the temperature of the drying in the step S6 is 45-60 ℃.
Preferably, the temperature of the drying in S6 is 55 ℃.
The mixing time in the step S2 is 10-20min.
And in the step S6, the mixing time of the mixture A and the mixture B is 10-20min.
And (6) finishing the grains in the step (S) by installing a 10-30 mesh stainless steel screen through a swinging granulator.
And S6, screening by a swing type granulator and arranging a stainless steel screen with 10-30 meshes and 70-90 meshes.
Grinding borneol and artificial musk, sieving with a 50-70 mesh sieve, and uniformly mixing with the particles obtained after sieving in the step S6.
The mixing time in the step S7 is 10-20min.
Advantageous effects
1. The wanying particles prepared by the technology have good heat clearing effect, and simultaneously have the functions of detoxification and convulsion relieving, and particularly have good treatment effect on the state with gum, throat swelling and pain and dysphoria and easy convulsion, and particularly relieve the problem of mouth and tongue sore caused by high heat under the high heat state.
2. The wanying capsule prepared by the technology has good effects of cooling, detoxifying and relieving convulsion.
3. The obtained wanying particles have good processing stability through setting compatibility of different raw material proportions in the technology.
4. The universal particles prepared by the technology have good stability, low water absorption change rate and high long-term storage stability.
Detailed Description
Example 1
The preparation raw materials of the wanying granule comprise the following components in parts by weight: 60 parts of coptis chinensis, 60 parts of rhizoma picrorhizae, 60 parts of catechu, 120 parts of aromatic ink, 3.6 parts of borneol, 12 parts of bear gall powder, 3 parts of artificial musk, 3 parts of in-vitro cultured bezoar and 96 parts of ox bile.
The rhizoma Coptidis, rhizoma picrorhizae, catechu, herba Cymbopogonis, borneolum Syntheticum, fel Ursi powder, artificial Moschus, and in vitro cultured calculus bovis and fel bovis seu Bubali are obtained by commercial purchase.
The preparation method of the all-purpose granule comprises the following steps:
s1, crushing 60 parts of rhizoma picrorhizae, 60 parts of rhizoma coptidis, 60 parts of catechu and 120 parts of aromatic ink to form mixed powder;
s2, mixing 3 parts of in-vitro cultured bezoar with the mixed powder in the S1 to obtain a mixture a;
s3, adding 12 parts of bear gall powder into a proper amount of purified water, boiling and dissolving to obtain bear gall powder liquid;
s4, concentrating 96 parts of oxgall and filtering to obtain oxgall paste;
s5, adding a proper amount of purified water into the ox gall paste and the bear gall powder liquid, and mixing to obtain a mixture b;
s6, adding 675 parts of powdered sugar into the mixture a, uniformly mixing, adding the mixture into the mixture b, adding an aqueous solution containing ethanol, stirring, granulating by a granulator, drying, granulating, and screening;
s7, grinding 3.6 parts of borneol and 3 parts of artificial musk, uniformly mixing with the particles subjected to screening in the S6, and sub-packaging to obtain the wanying particles.
The particle size of the in vitro cultured bezoar in S2 is 175 μm.
In the step S1, rhizoma picrorhizae, rhizoma Coptidis, catechu and aromatic ink are crushed to form mixed powder with particle diameter of 175 μm.
The grain diameter of the sugar powder in the S2 is 170 mu m, and the sugar powder is sucrose powder.
The water quantity in the S3 is 1.5 times of the weight of the bear gall powder.
The adding amount of the purified water in the step S5 is proper and is determined according to the state that the cattle gall paste and the bear gall powder liquid can be prepared into a wetting agent in actual production.
And the volume fraction of the ethanol added into the aqueous solution containing the ethanol in the step S6 is 80 percent.
The weight part of the aqueous solution containing ethanol added in the step S6 can be controlled to 238 parts.
The temperature of the drying in S6 is 55 ℃.
The mixing time in the step S2 is 10min.
And in the step S6, the mixing time of the mixture a and the mixture b is 20min.
And (6) finishing the grains in the step (S) by installing a 10-mesh stainless steel screen through a swinging type granulator.
And S6, screening by a swing type granulator and installing a 10-mesh and 80-mesh stainless steel screen.
Grinding borneol and artificial musk, sieving with a 60-mesh sieve, and uniformly mixing with the particles obtained after sieving in the step S6.
And (3) subpackaging in the step S7 to prepare the universal granules with the weight of 1g per bag.
The wanying granule is taken according to 1-2 bags once, 2 times a day and the dosage of children within 3 years old.
Example 2
Example 2 provides a capsule prepared from the preparation raw materials of the wanying granule, wherein the capsule comprises the following preparation raw materials in parts by weight: 54 parts of coptis chinensis, 54 parts of rhizoma picrorhizae, 54 parts of catechu, 108 parts of aromatic ink, 3.3 parts of borneol, 10.8 parts of bear gall powder, 2.7 parts of artificial musk, 2.7 parts of in-vitro cultured bezoar and 87 parts of oxgall.
The rhizoma Coptidis, rhizoma picrorhizae, catechu, herba Cymbopogonis, borneolum Syntheticum, fel Ursi powder, artificial Moschus, and in vitro cultured calculus bovis and fel bovis seu Bubali are obtained by commercial purchase.
The preparation method of the all-purpose capsule comprises the following steps:
s1, crushing 54 parts of rhizoma picrorhizae, 54 parts of coptis chinensis, 54 parts of catechu and 108 parts of aromatic ink to form mixed powder;
s2, mixing 2.7 parts of in-vitro cultured bezoar with the mixed powder in the S1 to obtain a mixture A;
s3, adding a proper amount of purified water into 10.8 parts of bear gall powder, boiling and dissolving to obtain bear gall powder liquid;
s4, concentrating 87 parts of oxgall and filtering to obtain oxgall paste;
s5, adding 95% ethanol into the ox gall paste and bear gall powder liquid, and mixing to obtain a mixture B;
s6, mixing the mixture A and the mixture B, adding an ethanol aqueous solution containing ethanol, stirring, granulating by a granulator, drying, granulating, and screening;
s7, grinding 3.3 parts of borneol and 2.7 parts of artificial musk, uniformly mixing with the particles subjected to the screening in the S6 to obtain mixed particles, and filling the mixed particles into a hollow capsule to obtain the Wan Ying capsule.
The particle size of the in vitro cultured bezoar is 175 mu m.
The mixed particles of 0.3g in the Wan Ying capsule are obtained in the step S7.
In the step S1, rhizoma picrorhizae, rhizoma Coptidis, catechu and aromatic ink are crushed to form mixed powder with particle diameter of 175 μm.
The water quantity in the S3 is 0.35 times of the weight of the bear gall powder.
The volume fraction of ethanol in the ethanol aqueous solution in the step S5 is 95%.
The addition amount of the aqueous solution containing ethanol in the step S5 is proper and is determined according to the state that the ox gall paste and the bear gall powder liquid can be prepared into a wetting agent in actual production.
And in the step S5, the volume fraction of the 95% ethanol in the ethanol water solution is 95%.
And (3) adding 95% of ethanol by volume into the aqueous solution containing ethanol in the step S6.
The weight parts of the aqueous solution containing ethanol added in the step S5 and the step S6 can be controlled to be 62.5 parts, and the addition amount in each step is determined according to the state of materials in actual production.
The drying temperature in S6 is 50 ℃.
The mixing time in the step S2 is 10min.
And in the step S6, the mixing time of the mixture A and the mixture B is 20min.
And (6) finishing the grains in the step (S) by installing a 20-mesh stainless steel screen through a swinging type granulator.
And S6, screening by a swing type granulator and installing a 20-mesh and 80-mesh stainless steel screen.
Grinding borneol and artificial musk, sieving with a 60-mesh sieve, and uniformly mixing with the particles obtained after sieving in the step S6.
The mixing time in the step S7 is 10min.
Example 3
The preparation raw materials of the wanying granule comprise the following components in parts by weight: 60 parts of coptis chinensis, 60 parts of rhizoma picrorhizae, 60 parts of catechu, 120 parts of aromatic ink, 3.6 parts of borneol, 12 parts of bear gall powder, 3 parts of artificial musk, 3 parts of in-vitro cultured bezoar and 96 parts of ox bile.
The rhizoma Coptidis, rhizoma picrorhizae, catechu, herba Cymbopogonis, borneolum Syntheticum, fel Ursi powder, artificial Moschus, and in vitro cultured calculus bovis and fel bovis seu Bubali are obtained by commercial purchase.
The preparation method of the all-purpose granule comprises the following steps:
s1, crushing 60 parts of rhizoma picrorhizae, 60 parts of rhizoma coptidis, 60 parts of catechu and 120 parts of aromatic ink to form mixed powder;
s2, mixing 3 parts of in-vitro cultured bezoar with the mixed powder in the S1 to obtain a mixture a;
s3, adding 12 parts of bear gall powder into a proper amount of purified water, boiling and dissolving to obtain bear gall powder liquid;
s4, concentrating 96 parts of oxgall and filtering to obtain oxgall paste;
s5, adding a proper amount of purified water into the ox gall paste and the bear gall powder liquid, and mixing to obtain a mixture b;
s6, adding 675 parts of powdered sugar into the mixture a, uniformly mixing, adding the mixture into the mixture b, adding an aqueous solution containing ethanol, stirring, granulating by a granulator, drying, granulating, and screening;
s7, grinding 3.6 parts of borneol and 3 parts of artificial musk, uniformly mixing with the particles subjected to screening in the S6, and sub-packaging to obtain the wanying particles.
The particle size of the in vitro cultured bezoar in S2 is 175 μm.
In the step S1, rhizoma picrorhizae, rhizoma Coptidis, catechu and aromatic ink are crushed to form mixed powder with particle diameter of 175 μm.
The grain diameter of the sugar powder in the S2 is 170 mu m, and the sugar powder is sucrose powder.
The water quantity in the S3 is 1.5 times of the weight of the bear gall powder.
The adding amount of the purified water in the step S5 is proper and is determined according to the state that the cattle gall paste and the bear gall powder liquid can be prepared into a wetting agent in actual production.
And the volume fraction of the ethanol added into the aqueous solution containing the ethanol in the step S6 is 80 percent.
The weight part of the aqueous solution containing ethanol added in the step S6 can be controlled to 238 parts.
The drying temperature in S6 is 70 ℃.
The mixing time in the step S2 is 10min.
And in the step S6, the mixing time of the mixture a and the mixture b is 20min.
And (6) finishing the grains in the step (S) by installing a 10-mesh stainless steel screen through a swinging type granulator.
And S6, screening by a swing type granulator and installing a 10-mesh and 80-mesh stainless steel screen.
Grinding borneol and artificial musk, sieving with a 60-mesh sieve, and uniformly mixing with the particles obtained after sieving in the step S6.
And (3) subpackaging in the step S7 to prepare the universal granules with the weight of 1g per bag.
The wanying granule is taken according to 1-2 bags once, 2 times a day and the dosage of children within 3 years old.
Example 4
The preparation raw materials of the wanying granule comprise the following components in parts by weight: 45 parts of coptis chinensis, 45 parts of rhizoma picrorhizae, 60 parts of catechu, 120 parts of aromatic ink, 3.6 parts of borneol, 12 parts of bear gall powder, 3 parts of artificial musk, 3 parts of in-vitro cultured bezoar and 96 parts of oxgall.
The rhizoma Coptidis, rhizoma picrorhizae, catechu, herba Cymbopogonis, borneolum Syntheticum, fel Ursi powder, artificial Moschus, and in vitro cultured calculus bovis and fel bovis seu Bubali are obtained by commercial purchase.
The preparation method of the all-purpose granule comprises the following steps:
s1, crushing 45 parts of rhizoma picrorhizae, 45 parts of rhizoma coptidis, 60 parts of catechu and 120 parts of aromatic ink to form mixed powder;
s2, mixing 3 parts of in-vitro cultured bezoar with the mixed powder in the S1 to obtain a mixture a;
s3, adding 12 parts of bear gall powder into a proper amount of purified water, boiling and dissolving to obtain bear gall powder liquid;
s4, concentrating and filtering 96 parts of ox gall to obtain ox gall paste;
s5, adding a proper amount of purified water into the ox gall paste and the bear gall powder liquid, and mixing to obtain a mixture b;
s6, adding 675 parts of powdered sugar into the mixture a, uniformly mixing, adding the mixture into the mixture b, adding an ethanol aqueous solution containing ethanol, stirring, granulating by a granulator, drying, granulating, and screening;
s7, grinding 3.6 parts of borneol and 3 parts of artificial musk, uniformly mixing with the particles subjected to screening in the S6, and sub-packaging to obtain the wanying particles.
The particle size of the in vitro cultured bezoar in S2 is 175 μm.
In the step S1, rhizoma picrorhizae, rhizoma Coptidis, catechu and aromatic ink are crushed to form mixed powder with particle diameter of 175 μm.
The grain diameter of the sugar powder in the S2 is 170 mu m, and the sugar powder is sucrose powder.
The water quantity in the S3 is 1.5 times of the weight of the bear gall powder.
The adding amount of the purified water in the step S5 is proper and is determined according to the state that the cattle gall paste and the bear gall powder liquid can be prepared into a wetting agent in actual production.
And the volume fraction of ethanol added into the aqueous solution containing ethanol in the step S6 is 50%.
The weight part of the aqueous solution containing ethanol added in the step S6 can be controlled to 238 parts.
The drying temperature in S6 is 50 ℃.
The mixing time in the step S2 is 10min.
And in the step S6, the mixing time of the mixture a and the mixture b is 20min.
And (6) finishing the grains in the step (S) by installing a 10-mesh stainless steel screen through a swinging type granulator.
And S6, screening by a swing type granulator and installing a 10-mesh and 80-mesh stainless steel screen.
Grinding borneol and artificial musk, sieving with a 60-mesh sieve, and uniformly mixing with the particles obtained after sieving in the step S6.
And (3) subpackaging in the step S7 to prepare the universal granules with the weight of 1g per bag.
The wanying granule is taken according to 1-2 bags once, 2 times a day and the dosage of children within 3 years old.
Performance testing
1. The various granules and capsules prepared in examples 1-4 were stored for 0-12 months for moisture content testing, and the test results are shown in Table 1.
2. Application tests were performed on the wan ying granules and the wan ying capsules prepared in examples 1 and 2, and the test results are shown in table 2.
The testing method comprises the following steps:
1. moisture content testing: 10 parts of the Wan Ying particles and the Wan Ying capsules prepared in examples 1-4 are taken, 1g of particles are taken in each part, the mixture is placed in a weighing bottle, the weighing bottle is dried in an oven at 100-105 ℃ for 5 hours, a weighing bottle cap is changed, the mixture is cooled for 30 minutes, weighing is carried out, the water content is calculated according to the mass ratio of the difference between the particles before and after drying to the particles before drying, and the maximum value and the minimum value are removed to obtain the average value.
2. Application test: selecting rabbits with a weight of 2.5 Kg, disabling water for 15h before testing, measuring normal anal temperature for 2 times at intervals of 1h, selecting rabbits with a temperature difference of not more than 0.3 ℃ for two times, injecting typhoid vaccine into the rabbits from the veins at the edge of the ears according to the amount of 0.3ml/Kg, measuring the body temperature after 1 hour, taking heat-generating rabbits with a temperature of more than 0.8 ℃ and selecting 20 rabbits into 2 groups, respectively taking 0.15g of particles in the Wanzhen granules and Wanzhen capsules prepared in examples 1 and 2 melted in water, and respectively testing the average body temperature of the rabbits after 1h, 2h, 3h, 4h and 5h of taking.
TABLE 1
TABLE 2
Claims (4)
1. The preparation method of the all-purpose granule is characterized by comprising the following raw materials in parts by weight: 50-65 parts of coptis chinensis, 50-65 parts of rhizoma picrorhizae, 50-65 parts of catechu, 105-125 parts of aromatic ink, 3-4 parts of borneol, 10.2-12 parts of bear gall powder, 2-3.5 parts of artificial musk, 2-3.5 parts of in-vitro cultured bezoar and 80-98 parts of ox gall;
the particle size of the in vitro cultured bezoar is 170-190 mu m;
the preparation method of the universal granule comprises the following steps:
s1, crushing rhizoma picrorhizae, coptis chinensis, catechu and aromatic ink to form mixed powder;
s2, mixing the in-vitro cultured bezoar with the mixed powder in the S1 to obtain a mixture a;
s3, adding a proper amount of purified water into bear gall powder, boiling and dissolving to obtain bear gall powder liquid;
s4, concentrating and filtering the oxgall to obtain oxgall paste;
s5, adding a proper amount of purified water into the ox gall paste and the bear gall powder liquid, and stirring and mixing to obtain a mixture b;
s6, adding sugar powder into the mixture a, uniformly mixing, adding the mixture into the mixture b, adding an aqueous solution containing ethanol, stirring, granulating, drying, granulating and screening;
s7, grinding borneol and artificial musk, uniformly mixing with the particles subjected to the screening in the S6, and sub-packaging to obtain the Wanzi particles;
the volume fraction of the ethanol in the aqueous solution containing the ethanol is 80-95% in the S6;
the drying temperature in the step S6 is 45-60 ℃.
2. The method for preparing the refractory particles according to claim 1, wherein the drying temperature in S6 is 50 to 60 ℃.
3. The method for preparing the wanying particles according to claim 1, wherein the finishing in the step S6 is carried out by arranging a 10-mesh stainless steel screen on a swinging granulator.
4. The method for preparing the wanying particles according to claim 1, wherein the screening in the step S6 is carried out by installing a 10-mesh and 80-mesh stainless steel screen mesh on a swing type particle machine.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1364478A (en) * | 2001-01-12 | 2002-08-21 | 杨孟君 | Nano wanyingding medicine and its prepairng method |
| CN107496375A (en) * | 2017-07-31 | 2017-12-22 | 陕西医药控股医药研究院有限公司 | A kind of preparation method of herbal mixture granule |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1364478A (en) * | 2001-01-12 | 2002-08-21 | 杨孟君 | Nano wanyingding medicine and its prepairng method |
| CN107496375A (en) * | 2017-07-31 | 2017-12-22 | 陕西医药控股医药研究院有限公司 | A kind of preparation method of herbal mixture granule |
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| 国家药典委员会编.中华人民共和国药典 2020年版 一部.中国医药科技出版社,2020,(第1版),526. * |
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