CN115191488A - Formula milk powder for improving immunity of children and preparation method thereof - Google Patents
Formula milk powder for improving immunity of children and preparation method thereof Download PDFInfo
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- CN115191488A CN115191488A CN202210519269.5A CN202210519269A CN115191488A CN 115191488 A CN115191488 A CN 115191488A CN 202210519269 A CN202210519269 A CN 202210519269A CN 115191488 A CN115191488 A CN 115191488A
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- milk powder
- composite
- parts
- vitamin
- preparing
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/16—Agglomerating or granulating milk powder; Making instant milk powder; Products obtained thereby
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
- A23C9/1526—Amino acids; Peptides; Protein hydrolysates; Nucleic acids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
- A23C9/1528—Fatty acids; Mono- or diglycerides; Petroleum jelly; Paraffine; Phospholipids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
- A23C9/154—Milk preparations; Milk powder or milk powder preparations containing additives containing thickening substances, eggs or cereal preparations; Milk gels
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
- A23C9/158—Milk preparations; Milk powder or milk powder preparations containing additives containing vitamins or antibiotics
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/51—Bifidobacterium
- A23V2400/531—Lactis
Abstract
The invention belongs to the technical field of food science and discloses a formula milk powder for improving the immunity of children and a preparation method thereof, wherein the formula milk powder for improving the immunity of children comprises, by mass, 30-50 parts of skimmed milk powder, 15-30 parts of concentrated whey protein, 15-20 parts of lactoferrin, 10-15 parts of composite small molecular polypeptide, 8-12 parts of hydrolyzed yolk powder, 6-10 parts of composite vitamin, 5-8 parts of composite vegetable oil, 3-5 parts of composite oligosaccharide, 2-4 parts of cubilose acid and 0.5-1.5 parts of bifidobacterium lactis. In the preparation process of the formula milk powder, the fructo-oligosaccharide and the bifidobacterium lactis are mixed, so that the fructo-oligosaccharide and the bb-12 bifidobacterium lactis can be uniformly matched, the survival rate of strains is high, and the strain stability and the mixing effect of the finished formula milk powder are good; the materials are mixed in batches according to different characteristics and functions, so that the components can play the maximum function.
Description
Technical Field
The invention belongs to the technical field of food science, and particularly relates to formula milk powder for improving the immunity of children and a preparation method thereof.
Background
At present, breast milk is the most suitable food for the nutritional needs of infants, but many mothers cannot guarantee sufficient breast feeding for various reasons, and need to use infant formula for feeding. Although the existing infant formula food in the market is milk powder which is prepared by taking cow milk and goat milk as base materials and adding nutrients, the infant formula food can provide sufficient nutrition for infants at different stages. However, mature breast milk is rich in proteins, structured fats (containing a high proportion of Sn-2 palmitic acid structured oil), minerals, vitamins, carbohydrates (mainly containing lactose and abundant oligosaccharides), and the like. Modern nutriology admittedly compares, and breast milk is the best food of infant and pre-school children, also is the gold standard of infant and pre-school children's breast milk powder.
Along with the gradual improvement of living standard, more and more attention is paid to nutrition and health, and the formula milk powder is used for supplementing nutrition required by the growth of children, so that the physique of the children can be enhanced, and the immunity is improved. However, the lack of dietary fiber in modern people's diet, but the excessive intake of high protein and high fat, has the easily resulted consequence that the balance of flora in the body is lost, thereby causing the body to be in sub-health state and even possibly suffering from diseases, the gastrointestinal function of children, especially infants, is not developed and mature, the immune function is still incomplete, the body resistance is weak, and the digestive dysfunction, intestinal malabsorption and infectious diseases are easy to occur. The intestinal flora has the functions of inhibiting the growth of pathogenic bacteria, preventing diseases, improving the immunity of the organism and the like. The intestinal tract is not only an important site for absorption, digestion and nutrient exchange, but also the largest immune organ of the human body. The intestinal microecology is the most complex and important microecological system of human body, has complex, wide and dynamic influence on human health, and has symbiotic and win-win ecological balance with host. However, the existing infant milk powder cannot contain beneficial components which are beneficial to intestinal beneficial bacteria, such as certain enzymes, immune proteins and peptides which can help digestion in breast milk. Therefore, the balance of the bacterial flora in the intestinal tract of the children is maintained, the advantages of the probiotics are kept, and the immunity of the children can be improved.
Through the above analysis, the problems and defects of the prior art are as follows: the existing infant milk powder cannot contain beneficial components which can help digestion, such as certain enzymes, immune proteins and peptides and the like and are beneficial to intestinal beneficial bacteria.
Disclosure of Invention
Aiming at the problems in the prior art, the invention provides a formula milk powder for improving the immunity of children and a preparation method thereof.
The formula milk powder for improving the immunity of children is prepared from 30-50 parts by mass of skimmed milk powder, 15-30 parts by mass of concentrated whey protein, 15-20 parts by mass of lactoferrin, 10-15 parts by mass of composite small molecular polypeptide, 8-12 parts by mass of hydrolyzed yolk powder, 6-10 parts by mass of composite vitamin, 5-8 parts by mass of composite vegetable oil, 3-5 parts by mass of composite oligosaccharide, 2-4 parts by mass of cubilose acid and 0.5-1.5 parts by mass of bifidobacterium lactis.
Further, the composite small molecule polypeptide is selected from any one or more of sea cucumber oligopeptide powder, thymus gland peptide, chinese yam peptide, medlar peptide and spirulina oligopeptide.
The compound vitamin is selected from one or more of calcium, iron, zinc, retinyl acetate, beta-carotene, cholecalciferol, thiamine hydrochloride, vitamin B2, nicotinamide, vitamin B4, pantothenic acid, vitamin B6, vitamin B12, vitamin B13, vitamin B15, L-sodium ascorbate, folic acid, taurine, lutein, vitamin F, biotin, vitamin K1, vitamin K2, vitamin E, sodium selenite, inositol and choline.
The composite vegetable oil is prepared from corn oil, sunflower seed oil, soybean oil, kiwi fruit kernel oil and coconut oil according to the ratio of 1:0.5 to 1.2:0.2 to 0.3:1:1 in parts by mass.
The compound oligosaccharide is selected from one or more of fructo-oligosaccharide, malto-oligosaccharide, galacto-oligosaccharide GOS and chitosan oligosaccharide.
The invention also aims to provide a preparation method of the formula milk powder for improving the immunity of children, which implements the formula milk powder for improving the immunity of children, and the preparation method of the formula milk powder for improving the immunity of children comprises the following steps:
step one, preparing skim milk powder: diluting qualified skimmed milk by using sterilized deionized water, and dialyzing and intercepting by using an ultrafiltration membrane; adding lactase for hydrolysis after pasteurization, and desalting by electrodialysis; separating again by nanofiltration membrane, sterilizing, vacuum concentrating, filtering, and spray drying the filtrate to obtain skimmed milk powder;
step two, preparing concentrated whey protein: sequentially carrying out ultrasonic treatment and dynamic high-pressure micro-jet treatment on the whey protein solution, and concentrating under the action of hot air; spraying glucose solution in the concentration process, reacting completely, contacting with Bacillus licheniformis protease and trypsin for enzymolysis, spray drying, and sieving to obtain concentrated whey protein;
step three, preparing hydrolyzed yolk powder: mixing egg yolk, sterilized deionized water and protease, reacting, heating, adding lecithin and bioactive components, and drying to obtain hydrolyzed egg yolk powder;
step four, preparing the formula milk powder: respectively weighing the raw materials, mixing the skimmed milk powder, the concentrated whey protein, the lactoferrin, the composite vegetable oil and the hydrolyzed yolk powder, preheating, homogenizing and sterilizing, adding the composite micromolecule polypeptide, the composite vitamin, the composite oligosaccharide, the bird's nest acid and the bifidobacterium lactis, and uniformly mixing to obtain the formula milk powder.
Further, the preparation method of the skim milk powder in the first step comprises the following steps:
(1) Adding 4-10 times of sterilized deionized water by weight into the skim milk qualified by inspection for dilution, dialyzing the diluted milk for 3-6 times by an ultrafiltration membrane to intercept protein, and obtaining penetrating fluid containing protein, dietary fiber, lactose and inorganic salt;
(2) Pasteurizing the penetrating fluid at 60-80 ℃ for 15-30 s, cooling to 35-40 ℃, adding lactase with the amount 0.5-0.6 time that of the penetrating fluid, and hydrolyzing at 35-40 ℃ for 2-4 h to obtain hydrolysate;
(3) Desalting the hydrolysate through electrodialysis to obtain concentrated solution rich in inorganic salt and desalted solution containing protein and dietary fiber; separating the desalted solution again from inorganic salt, protein and dietary fiber by a nanofiltration membrane to obtain lactose-free skim milk;
(4) Sterilizing the non-lactose skim milk by adopting an ultrahigh-temperature instantaneous sterilization method, immediately performing vacuum concentration, and concentrating to 1/4 of the volume of the raw milk; after concentration, the concentrated milk is filtered by a duplex filter, and the filtrate is spray-dried to obtain the skimmed milk powder.
Further, the ultrafiltration membrane is a flat membrane, a ceramic membrane, a hollow fiber membrane or a spiral membrane module, and the membrane adopted by the electrodialysis is a heterogeneous, homogeneous or semi-homogeneous ion exchange membrane;
the temperature of the high-temperature instantaneous sterilization is 120-150 ℃, and the sterilization time is 1-3 s.
Further, the preparation method of the concentrated whey protein in the second step comprises:
(1) Carrying out ultrasonic treatment on the whey protein solution by an ultrasonic device, and then carrying out dynamic high-pressure micro-jet treatment again to obtain a pretreated whey protein solution;
(2) Concentrating the pretreated whey protein solution under the action of hot air from bottom to top to make the concentrated whey protein in a flowing state, and spraying glucose solution in a spraying manner to obtain a glycosylation modified whey protein solution;
(3) Contacting the glycosylation modified whey protein particles with bacillus licheniformis protease and trypsin, performing enzymolysis, spray drying, and sieving to obtain concentrated whey protein.
Further, the ultrasonic power is 600-1200W, and the ultrasonic time is 10-30 min;
the pressure of the dynamic high-pressure micro-jet treatment is 100-200 MPa, and the treatment is carried out for 2-4 times.
Further, the preparation method of the hydrolyzed egg yolk powder in the third step comprises the following steps:
(1) Egg yolk, sterilized deionized water and protease were mixed according to a 20:30 to 50:1, heating to 30-35 ℃ for reaction after mixing;
(2) After the reaction is finished, heating to 40-50 ℃ for hydrothermal treatment for 20-30 min to prepare an egg yolk protein fiber aggregate;
(3) And (3) mixing the yolk protein fiber aggregates obtained in the step (2) with lecithin, adding a bioactive component to obtain emulsion, and drying to obtain the hydrolyzed yolk powder.
Further, the mass portion of the bioactive components in the emulsion is 5-20%.
Further, the preparation method of the formula milk powder in the fourth step comprises the following steps:
(1) Weighing skimmed milk powder, concentrated whey protein, lactoferrin, composite small molecular polypeptide, hydrolyzed yolk powder, composite vitamin, composite vegetable oil, composite oligosaccharide, bird's nest acid and bifidobacterium lactis respectively;
(2) Mixing skimmed milk powder, concentrated whey protein, lactoferrin, compound vegetable oil and hydrolyzed yolk powder at 15-25 ℃, and stirring for 20-40 min to obtain a premix;
(3) Preheating, homogenizing and sterilizing the premix; the pressure is controlled to be 15-20 Mpa during homogenizing, and the temperature is controlled to be 55-65 ℃; when the two-stage homogenization is carried out, the first-stage pressure is 15-20 Mpa, and the second-stage pressure is 30-35 Mpa;
(4) And pouring the composite small molecular polypeptide, the composite vitamin, the composite oligosaccharide, the cubilose acid and the bifidobacterium lactis into the pre-heated, homogenized and sterilized premix, and stirring and mixing uniformly to obtain the formula milk powder.
In combination with the technical solutions and the technical problems to be solved, please analyze the advantages and positive effects of the technical solutions to be protected in the present invention from the following aspects:
first, aiming at the technical problems existing in the prior art and the difficulty in solving the problems, the technical problems to be solved by the technical scheme of the present invention are closely combined with results, data and the like in the research and development process, and some creative technical effects are brought after the problems are solved. The specific description is as follows:
according to the invention, in the preparation process of the formula milk powder for improving the immunity of children, the fructo-oligosaccharide and the bifidobacterium lactis are mixed, so that the fructo-oligosaccharide and the bb-12 bifidobacterium lactis can be uniformly matched, the survival rate of strains is high, the strain stability of the finished formula milk powder is better, and the mixing effect of the milk powder is better; a multi-step mixing method is adopted, and various materials are mixed in batches according to different characteristics and effects, so that the materials can play the greatest role.
Meanwhile, the prepared formula milk powder for improving the immunity of children can improve the intestinal flora of children by adding the composite micromolecular polypeptide and the prebiotics, can balance nutrition, and can effectively improve the function of immune cells especially in high-quality unsaturated fatty acid.
Secondly, considering the technical scheme as a whole or from the perspective of products, the technical effect and advantages of the technical scheme to be protected by the invention are specifically described as follows:
the preparation method of the formula milk powder for improving the immunity of children provided by the invention is simple and easy to operate, and the prepared formula milk powder has a good effect on the intestinal environment and can effectively improve the immunity of the organisms of children.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings needed to be used in the embodiments of the present invention will be briefly described below, and it is obvious that the drawings described below are only some embodiments of the present invention, and it is obvious for those skilled in the art that other drawings can be obtained according to the drawings without creative efforts.
FIG. 1 is a flow chart of a method for preparing a formula milk powder for improving immunity of children according to an embodiment of the invention;
FIG. 2 is a flow chart of a method for preparing concentrated whey protein according to an embodiment of the present invention;
fig. 3 is a flow chart of a method for preparing hydrolyzed egg yolk powder according to an embodiment of the present invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and do not limit the invention.
In order to solve the problems in the prior art, the invention provides a formula milk powder for improving children immunity and a preparation method thereof, and the invention is described in detail with reference to the accompanying drawings.
1. The embodiments are explained. This section is an explanatory embodiment expanding on the claims so as to fully understand how the present invention is embodied by those skilled in the art.
The formula milk powder for improving the immunity of children provided by the embodiment of the invention comprises 30-50 parts of skimmed milk powder, 15-30 parts of concentrated whey protein, 15-20 parts of lactoferrin, 10-15 parts of composite small molecular polypeptide, 8-12 parts of hydrolyzed yolk powder, 6-10 parts of composite vitamin, 5-8 parts of composite vegetable oil, 3-5 parts of composite oligosaccharide, 2-4 parts of cubilose acid and 0.5-1.5 parts of bifidobacterium lactis according to parts by mass.
The composite small molecular polypeptide provided by the embodiment of the invention is a composition of any one or more of sea cucumber oligopeptide powder, thymus gland peptide, chinese yam peptide, medlar peptide and spirulina oligopeptide.
The multivitamins provided in the embodiments of the present invention are selected from a variety of compositions of calcium, iron, zinc, retinyl acetate (vitamin a), beta-carotene (vitamin a), cholecalciferol (vitamin D3), thiamine hydrochloride (vitamin B1), vitamin B2, nicotinamide (vitamin B3), vitamin B4 (6-aminopurine), pantothenic acid (vitamin B5), vitamin B6, vitamin B12, vitamin B13, vitamin B15, sodium L-ascorbate (vitamin C), folic acid, taurine, lutein, vitamin F (linoleic acid), biotin (vitamin H), vitamin K1, vitamin K2, vitamin E, sodium selenite, inositol, and choline.
The composite vegetable oil provided by the embodiment of the invention is prepared from corn oil, sunflower seed oil, soybean oil, rapeseed oil and coconut oil according to the weight ratio of 1:0.5 to 1.2:0.2 to 0.3:1:1 in parts by mass.
The composite oligosaccharide provided by the embodiment of the invention is a composition of any one or more of fructo oligosaccharide, malto oligosaccharide, galacto oligosaccharide GOS and chitosan oligosaccharide.
As shown in fig. 1, the preparation method of the formula milk powder for improving immunity of children provided by the embodiment of the invention comprises the following steps:
s101, preparing skim milk powder: diluting qualified skimmed milk by using sterilized deionized water, and dialyzing and intercepting by using an ultrafiltration membrane; adding lactase for hydrolysis after pasteurization, and desalting by electrodialysis; separating again by nanofiltration membrane, sterilizing, vacuum concentrating, filtering, and spray drying the filtrate to obtain defatted milk powder;
s102, preparing concentrated whey protein: sequentially carrying out ultrasonic treatment and dynamic high-pressure micro-jet treatment on the whey protein solution, and concentrating under the action of hot air; spraying glucose solution in the concentration process, reacting completely, contacting with Bacillus licheniformis protease and trypsin for enzymolysis, spray drying, and sieving to obtain concentrated whey protein;
s103, preparing hydrolyzed egg yolk powder: mixing yolk, sterilized deionized water and protease, reacting, heating, adding lecithin and bioactive components, and drying to obtain hydrolyzed yolk powder;
s104, preparing formula milk powder: respectively weighing raw materials, mixing the skimmed milk powder, the concentrated whey protein, the lactoferrin, the compound vegetable oil and the hydrolyzed yolk powder, preheating, homogenizing and sterilizing, adding the compound small molecular polypeptide, the compound vitamin, the compound oligosaccharide, the cubilose acid and the bifidobacterium lactis, and uniformly mixing to obtain the formula milk powder.
The preparation method of the skimmed milk powder in the step S101 provided by the embodiment of the invention comprises the following steps:
(1) Adding 4-10 times of sterilized deionized water by weight into the skim milk qualified by inspection for dilution, dialyzing the diluted milk for 3-6 times by an ultrafiltration membrane to intercept protein, and obtaining penetrating fluid containing protein, dietary fiber, lactose and inorganic salt;
(2) Pasteurizing the penetrating fluid at 60-80 ℃ for 15-30 s, cooling to 35-40 ℃, adding lactase with the amount 0.5-0.6 time that of the penetrating fluid, and hydrolyzing at 35-40 ℃ for 2-4 h to obtain hydrolysate;
(3) Desalting the hydrolysate through electrodialysis to obtain concentrated solution rich in inorganic salt and desalted solution containing protein and dietary fiber; separating the desalted solution again from inorganic salt, protein and dietary fiber by a nanofiltration membrane to obtain lactose-free skim milk;
(4) Sterilizing the non-lactose skim milk by adopting an ultrahigh-temperature instantaneous sterilization method, immediately performing vacuum concentration, and concentrating to 1/4 of the volume of the raw milk; and after concentration, filtering the concentrated milk by adopting a duplex filter, and performing spray drying on the filtrate to obtain the skimmed milk powder.
The ultrafiltration membrane provided by the embodiment of the invention is a flat membrane, a ceramic membrane, a hollow fiber membrane or a spiral membrane module, and the membrane adopted by electrodialysis is a heterogeneous, homogeneous or semi-homogeneous ion exchange membrane; the temperature of high-temperature instantaneous sterilization is 120-150 ℃, and the sterilization time is 1-3 s.
As shown in fig. 2, the preparation method of the concentrated whey protein in step S102 according to the embodiment of the present invention includes:
s201, carrying out ultrasonic treatment on the whey protein solution through an ultrasonic device, and then carrying out dynamic high-pressure micro-jet treatment again to obtain a pretreated whey protein solution;
s202, concentrating the pretreated whey protein solution under the action of hot air from bottom to top to enable the concentrated whey protein to be in a flowing state, and spraying a glucose solution in a spraying mode to obtain a glycosylation modified whey protein solution;
s203, contacting the glycosylation modified whey protein particles with bacillus licheniformis protease and trypsin, carrying out enzymolysis, carrying out spray drying, and sieving to obtain the concentrated whey protein.
The ultrasonic power provided by the embodiment of the invention is 600-1200W, and the ultrasonic time is 10-30 min; the pressure of the dynamic high-pressure micro-jet treatment is 100-200 MPa, and the treatment is carried out for 2-4 times.
As shown in fig. 3, the preparation method of the hydrolyzed egg yolk powder of step S103 according to the embodiment of the present invention includes:
s301, mixing egg yolk, sterilized deionized water and protease according to the ratio of 20:30 to 50:1, heating to 30-35 ℃ for reaction after mixing;
s302, after the reaction is finished, heating to 40-50 ℃ for hydrothermal treatment for 20-30 min to prepare the yolk protein fiber aggregate;
and S303, mixing the yolk protein fiber aggregates obtained in the S302 with lecithin, adding a bioactive component to obtain emulsion, and drying to obtain the hydrolyzed yolk powder.
The bioactive components provided by the embodiment of the invention are 5-20% of the emulsion by weight.
The preparation method of the formula milk powder in the step S104 provided by the embodiment of the invention comprises the following steps:
(1) Respectively weighing skimmed milk powder, concentrated whey protein, lactoferrin, composite small molecular polypeptide, hydrolyzed yolk powder, composite vitamin, composite vegetable oil, composite oligosaccharide, bird's nest acid and bifidobacterium lactis;
(2) Mixing skimmed milk powder, concentrated whey protein, lactoferrin, compound vegetable oil and hydrolyzed yolk powder at 15-25 ℃, and stirring for 20-40 min to obtain a premix;
(3) Preheating, homogenizing and sterilizing the premix; the pressure is controlled to be 15-20 Mpa during homogenizing, and the temperature is controlled to be 55-65 ℃; when the two-stage homogenization is carried out, the first-stage pressure is 15-20 Mpa, and the second-stage pressure is 30-35 Mpa;
(4) And pouring the composite micromolecule polypeptide, the composite vitamin, the composite oligosaccharide, the cubilose acid and the bifidobacterium lactis into the pre-mixed material subjected to preheating, homogenizing and sterilizing treatment, and stirring and mixing uniformly to obtain the formula milk powder.
2. Application examples. In order to prove the creativity and the technical value of the technical scheme of the invention, the part is an application example of the technical scheme of the claims to a specific product or related technology.
The formula milk powder for improving the immunity of children, which is prepared by the preparation method of the formula milk powder for improving the immunity of children, provided by the embodiment of the invention, has the advantages of good strain stability, good milk powder mixing effect, good effect on the intestinal environment and capability of effectively improving the immunity of children.
Meanwhile, the composite micromolecular polypeptide is added to effectively improve the immunity and the prebiotics are added to improve the intestinal flora of children, so that the nutrition can be balanced, and particularly, the function of immune cells can be effectively improved in high-quality unsaturated fatty acid.
The above description is only for the purpose of illustrating the present invention and the appended claims are not to be construed as limiting the scope of the invention, which is intended to cover all modifications, equivalents and improvements that are within the spirit and scope of the invention as defined by the appended claims.
Claims (10)
1. The formula milk powder for improving the immunity of children is characterized by comprising 30-50 parts by mass of skimmed milk powder, 15-30 parts by mass of concentrated whey protein, 15-20 parts by mass of lactoferrin, 10-15 parts by mass of composite small molecular polypeptide, 8-12 parts by mass of hydrolyzed yolk powder, 6-10 parts by mass of composite vitamin, 5-8 parts by mass of composite vegetable oil, 3-5 parts by mass of composite oligosaccharide, 2-4 parts by mass of cubilose acid and 0.5-1.5 parts by mass of bifidobacterium lactis.
2. The formula milk powder for improving children immunity according to claim 1, wherein the composite small molecule polypeptide is selected from any one or more of sea cucumber oligopeptide powder, thymus gland peptide, chinese yam peptide, medlar peptide and spirulina oligopeptide;
the compound vitamin is selected from one or more of calcium, iron, zinc, retinyl acetate, beta-carotene, cholecalciferol, thiamine hydrochloride, vitamin B2, nicotinamide, vitamin B4, pantothenic acid, vitamin B6, vitamin B12, vitamin B13, vitamin B15, L-sodium ascorbate, folic acid, taurine, lutein, vitamin F, biotin, vitamin K1, vitamin K2, vitamin E, sodium selenite, inositol and choline;
the composite vegetable oil is prepared from corn oil, sunflower seed oil, soybean oil, kiwi fruit kernel oil and coconut oil according to the ratio of 1:0.5 to 1.2:0.2 to 0.3:1:1 in parts by mass;
the compound oligosaccharide is selected from one or more of fructo-oligosaccharide, malto-oligosaccharide, galacto-oligosaccharide GOS and chitosan oligosaccharide.
3. A method for preparing a formula milk powder for improving the immunity of children by using the formula milk powder for improving the immunity of children as claimed in any one of claims 1 to 2, wherein the method for preparing the formula milk powder for improving the immunity of children comprises the following steps:
step one, preparing skim milk powder: diluting qualified skim milk by using sterilized deionized water, and performing dialysis interception by using an ultrafiltration membrane; adding lactase for hydrolysis after pasteurization, and desalting by electrodialysis; separating again by nanofiltration membrane, sterilizing, vacuum concentrating, filtering, and spray drying the filtrate to obtain defatted milk powder;
step two, preparing concentrated whey protein: sequentially carrying out ultrasonic treatment and dynamic high-pressure micro-jet treatment on the whey protein solution, and concentrating under the action of hot air; spraying glucose solution in the concentration process, reacting completely, contacting with Bacillus licheniformis protease and trypsin for enzymolysis, spray drying, and sieving to obtain concentrated whey protein;
step three, preparing hydrolyzed yolk powder: mixing yolk, sterilized deionized water and protease, reacting, heating, adding lecithin and bioactive components, and drying to obtain hydrolyzed yolk powder;
step four, preparing the formula milk powder: respectively weighing the raw materials, mixing the skimmed milk powder, the concentrated whey protein, the lactoferrin, the composite vegetable oil and the hydrolyzed yolk powder, preheating, homogenizing and sterilizing, adding the composite micromolecule polypeptide, the composite vitamin, the composite oligosaccharide, the bird's nest acid and the bifidobacterium lactis, and uniformly mixing to obtain the formula milk powder.
4. The method for preparing a formula milk powder for improving children's immunity as claimed in claim 3, wherein the method for preparing the skimmed milk powder in the first step comprises:
(1) Adding 4-10 times of sterilized deionized water by weight into the skim milk qualified by inspection for dilution, dialyzing the diluted milk for 3-6 times by an ultrafiltration membrane to intercept protein, and obtaining penetrating fluid containing protein, dietary fiber, lactose and inorganic salt;
(2) Pasteurizing the penetrating fluid at 60-80 ℃ for 15-30 s, cooling to 35-40 ℃, adding lactase with the amount 0.5-0.6 time that of the penetrating fluid, and hydrolyzing at 35-40 ℃ for 2-4 h to obtain hydrolysate;
(3) Desalting the hydrolysate through electrodialysis to obtain concentrated solution rich in inorganic salt and desalted solution containing protein and dietary fiber; separating the desalted solution again from inorganic salt, protein and dietary fiber by a nanofiltration membrane to obtain lactose-free skim milk;
(4) Sterilizing the lactose-free skim milk by adopting an ultrahigh-temperature instantaneous sterilization method, immediately performing vacuum concentration, and concentrating to 1/4 of the volume of the raw milk; and after concentration, filtering the concentrated milk by adopting a duplex filter, and performing spray drying on the filtrate to obtain the skimmed milk powder.
5. The method for preparing the formula milk powder for improving the immunity of children according to claim 4, wherein the ultrafiltration membrane is a flat membrane, a ceramic membrane, a hollow fiber membrane or a spiral membrane module, and the membrane adopted by the electrodialysis is a heterogeneous, homogeneous or semi-homogeneous ion exchange membrane;
the temperature of the high-temperature instantaneous sterilization is 120-150 ℃, and the sterilization time is 1-3 s.
6. The method for preparing a formula milk powder for improving children's immunity as claimed in claim 3, wherein the method for preparing the concentrated whey protein in step two comprises:
(1) Carrying out ultrasonic treatment on the whey protein solution by an ultrasonic device, and then carrying out dynamic high-pressure micro-jet treatment again to obtain a pretreated whey protein solution;
(2) Concentrating the pretreated whey protein solution under the action of hot air from bottom to top to make the concentrated whey protein in a flowing state, and spraying glucose solution in a spraying manner to obtain a glycosylation modified whey protein solution;
(3) Contacting the glycosylation modified whey protein particles with bacillus licheniformis protease and trypsin, performing enzymolysis, spray drying, and sieving to obtain concentrated whey protein.
7. The method for preparing the formula milk powder for improving the immunity of children as claimed in claim 6, wherein the ultrasonic power is 600-1200W, and the ultrasonic time is 10-30 min;
the pressure of the dynamic high-pressure micro-jet treatment is 100-200 MPa, and the treatment is carried out for 2-4 times.
8. The method for preparing a formula milk powder for improving children's immunity according to claim 3, wherein the method for preparing the hydrolyzed egg yolk powder in step three comprises the following steps:
(1) Egg yolk, sterilized deionized water and protease were mixed according to a 20:30 to 50:1, heating to 30-35 ℃ for reaction after mixing;
(2) After the reaction is finished, heating to 40-50 ℃ for hydrothermal treatment for 20-30 min to prepare the egg yolk protein fiber aggregate;
(3) And (3) mixing the yolk protein fiber aggregates obtained in the step (2) with lecithin, adding a bioactive component to obtain emulsion, and drying to obtain the hydrolyzed yolk powder.
9. The method for preparing the formula milk powder for improving the immunity of children as claimed in claim 8, wherein the mass portion of the bioactive components in the emulsion is 5-20%.
10. The method for preparing a formula for improving children's immunity according to claim 3, wherein the method for preparing the formula in step four comprises:
(1) Respectively weighing skimmed milk powder, concentrated whey protein, lactoferrin, composite small molecular polypeptide, hydrolyzed yolk powder, composite vitamin, composite vegetable oil, composite oligosaccharide, bird's nest acid and bifidobacterium lactis;
(2) Mixing skimmed milk powder, concentrated whey protein, lactoferrin, compound vegetable oil and hydrolyzed yolk powder at 15-25 ℃, and stirring for 20-40 min to obtain a premix;
(3) Preheating, homogenizing and sterilizing the premix; the pressure is controlled to be 15-20 Mpa during homogenizing, and the temperature is controlled to be 55-65 ℃; when the two-stage homogenization is carried out, the first-stage pressure is 15-20 Mpa, and the second-stage pressure is 30-35 Mpa;
(4) And pouring the composite micromolecule polypeptide, the composite vitamin, the composite oligosaccharide, the cubilose acid and the bifidobacterium lactis into the pre-mixed material subjected to preheating, homogenizing and sterilizing treatment, and stirring and mixing uniformly to obtain the formula milk powder.
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