CN115096501A - Pipeline positive pressure threshold determination and abnormity warning method, controller, system and medium - Google Patents

Pipeline positive pressure threshold determination and abnormity warning method, controller, system and medium Download PDF

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Publication number
CN115096501A
CN115096501A CN202210750395.1A CN202210750395A CN115096501A CN 115096501 A CN115096501 A CN 115096501A CN 202210750395 A CN202210750395 A CN 202210750395A CN 115096501 A CN115096501 A CN 115096501A
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pressure
value
pipeline
positive pressure
target pipeline
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CN115096501B (en
Inventor
姚嘉林
邓温平
谢澎
乔德山
陈键邦
郭霄亮
商院芳
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Shenzhen Saiqiao Biological Innovation Technology Co Ltd
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Shenzhen Saiqiao Biological Innovation Technology Co Ltd
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Priority to PCT/CN2023/099697 priority patent/WO2024001745A1/en
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01L—MEASURING FORCE, STRESS, TORQUE, WORK, MECHANICAL POWER, MECHANICAL EFFICIENCY, OR FLUID PRESSURE
    • G01L19/00—Details of, or accessories for, apparatus for measuring steady or quasi-steady pressure of a fluent medium insofar as such details or accessories are not special to particular types of pressure gauges
    • G01L19/08—Means for indicating or recording, e.g. for remote indication
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/06—Tubular
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/14—Bags
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
    • C12M33/12—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus by pressure
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/40—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pressure
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48—Automatic or computerized control
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/04—Cell isolation or sorting

Abstract

The invention discloses a method, a device, equipment and a medium for determining a positive pressure threshold value of a pipeline and warning an abnormality, wherein the method comprises the following steps: receiving a pipe installation completion instruction of a target pipeline, and acquiring a normal pressure value of fluid in the target pipeline, the output end of which is communicated with outside air; executing positive pressure measurement starting operation on a target pipeline; after a pump in a target pipeline is started, acquiring a positive pressure gas pressure value of the target pipeline within a preset safety duration and acquiring time thereof; and acquiring a pipe replacement parameter in a pipe installation completion instruction, and determining a positive pressure threshold value of the target pipeline according to the pipe replacement parameter, the positive pressure gas pressure value, the acquisition time and the normal pressure value. According to the invention, after each pipe replacement operation, the positive pressure threshold can be automatically and accurately determined, the setting efficiency and accuracy of the positive pressure threshold are improved, the accuracy of abnormal warning in the cell separation process is ensured, and the smooth proceeding and safety of the cell separation process are further ensured.

Description

Pipeline positive pressure threshold determination and abnormity warning method, controller, system and medium
Technical Field
The invention relates to the technical field of cell separation, in particular to a method, a device, equipment and a medium for determining a positive pressure threshold value of a pipeline and warning abnormity.
Background
At present, cell therapy has become an emerging therapeutic approach, a cell separation method plays one of important roles in cell therapy, the cell separation method is often to separate mononuclear cells by a centrifuge cup, a blood sample needs to be injected into the centrifuge cup in the cell separation process, unnecessary liquid components in the centrifuge cup need to be discharged into a waste liquid bag, and the liquid flowing process is often realized by a peristaltic pump. When cell separation is carried out, the blockage of the centrifugal cup can cause the deep-fried cup, so that the whole centrifugal cup is unavailable and a blood sample is polluted; the blockage of the waste liquid bag can cause the problem that the unwanted liquid components can not be smoothly discharged, and the next operation can not be carried out, so that once the blockage occurs, blood samples can be greatly wasted, and great damage and loss can be caused to the patient in need of treatment.
In the prior art, in order to avoid the risk of abnormal pipeline occurrence, there is a scheme of setting a limit value corresponding to a relevant parameter of the pipeline for identifying abnormal blockage of cell separation, but because the various equipment and the connecting pipeline thereof are usually disposable products, the pipeline needs to be frequently replaced, and the material of the replaced pipeline may change (the replacement of the pipeline made of multiple materials by one cell separation machine may occur), therefore, the change operation of the pipeline may cause the change of the relevant parameter of the pipeline each time, and the relevant parameter of the pipeline is also influenced by the external environment, therefore, the accuracy of identifying abnormal blockage of the pipeline by setting the relevant parameter of the pipeline as a fixed limit value cannot be ensured, and the cell separation process cannot be carried out smoothly, and the safety cannot be ensured.
Disclosure of Invention
The embodiment of the invention provides a method, a device, equipment and a medium for determining a positive pressure threshold value of a pipeline and warning an abnormality, and aims to solve the problems that in the prior art, the accuracy of identifying abnormal blockage in a cell separation process cannot be guaranteed due to the fact that a pipeline related parameter is set to be a fixed limit value, and the like.
A method of positive pressure threshold determination for a pipeline, comprising:
receiving a pipe installation completion instruction of a target pipeline, and acquiring a normal pressure value of fluid in the target pipeline, wherein the output end of the fluid is communicated with outside air;
performing a positive pressure measurement start operation on the target pipeline;
after a pump in the target pipeline is started, acquiring a positive pressure gas pressure value of the target pipeline within a preset safety duration and acquiring time thereof;
and acquiring a pipe replacement parameter in the pipe installation completion instruction, and determining a positive pressure threshold value of the target pipeline according to the pipe replacement parameter, the positive pressure gas pressure value, the acquisition time and the normal pressure value.
An abnormity warning method of a cell separation system, wherein the cell separation system comprises a target pipeline, a liquid bag communicated with the input end of the target pipeline and a centrifugal cup communicated with the output end of the target pipeline; a first pressure sensor is arranged between the centrifugal cup and the pump of the target pipeline;
the cell separation system abnormity warning method comprises the following steps:
determining a positive pressure threshold value of a target pipeline in the cell separation system by the pipeline positive pressure threshold value determining method;
receiving a cell separation processing instruction, controlling a pump of the target pipeline to start and execute cell separation operation, and monitoring a first real-time pressure value in a fluid pipeline between the centrifugal cup and the pump of the target pipeline through the first pressure sensor;
and when the first real-time pressure value is larger than or equal to the positive pressure threshold value, controlling the pump to be closed, and prompting that the output end of the centrifugal cup or/and the target pipeline is abnormal through a first preset prompting mode.
A controller is used for executing the pipeline positive pressure threshold value determining method or the cell separation system abnormity warning method.
A cell separation system comprises a target pipeline, a liquid bag communicated with the input end of the target pipeline, a centrifugal cup communicated with the output end of the target pipeline and the controller, wherein a first pressure sensor is arranged between the centrifugal cup and a pump of the target pipeline; the controller communicates the first pressure sensor and the pump.
A computer-readable storage medium storing a computer program, wherein the computer program is executed by a processor to implement the method for determining a positive pressure threshold value of a pipeline, or the computer program is executed by a processor to implement the method for warning an abnormality in a cell separation system.
The pipeline positive pressure threshold value determining and abnormity warning method, device, equipment and medium comprise the following steps: receiving a pipe installation completion instruction of a target pipeline, and acquiring a normal pressure value of fluid in the target pipeline, wherein the output end of the fluid is communicated with outside air; performing a positive pressure measurement start operation on the target pipeline; after a pump in the target pipeline is started, acquiring a positive pressure gas pressure value of the target pipeline within a preset safety duration and acquiring time thereof; and acquiring a pipe replacement parameter in the pipe installation completion instruction, and determining a positive pressure threshold value of the target pipeline according to the pipe replacement parameter, the positive pressure gas pressure value, the acquisition time and the normal pressure value.
After the target pipeline receives a pipe installation completion instruction, at least part of pipes in the target pipeline are confirmed to be replaced, at the moment, positive pressure measurement starting operation is carried out on the target pipeline, so that a positive pressure environment is formed in a fluid pipeline between a pump and an output end of the target pipeline after the pump in the target pipeline is started, and further, a positive pressure threshold value of the target pipeline is automatically determined according to a normal pressure value measured before the pump is started, a positive pressure gas pressure value acquired after the pump is started, acquisition time of the positive pressure gas pressure value and the acquisition time of the positive pressure gas pressure value, and pipe replacement parameters corresponding to the replaced pipes. After each pipe replacement operation, the positive pressure threshold corresponding to the pipe replacement parameter can be accurately determined in a targeted manner by automatically combining with the outside air (external environment influence factors) and the pipe replacement parameter of the replaced pipe, the positive pressure threshold does not need to be manually set or adjusted, and the setting efficiency and accuracy of the positive pressure threshold are improved, so that the accuracy of warning the abnormity (such as blockage) of the cell separation process according to the automatically determined positive pressure threshold is ensured, and the cell separation process is further ensured to be smoothly carried out and the safety of the cell separation process is further ensured.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings needed to be used in the description of the embodiments of the present invention will be briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art that other drawings can be obtained according to these drawings without inventive labor.
FIG. 1 is a flow chart of a method of determining a positive pressure threshold in a pipeline in accordance with an embodiment of the present invention;
FIG. 2 is a flowchart illustrating the step S40 of the positive line pressure threshold determination method according to an embodiment of the present invention;
FIG. 3 is a flowchart of step S402 of a method for determining a positive line pressure threshold in accordance with an embodiment of the present invention;
FIG. 4 is a flow chart of an abnormal warning method for a cell separation system according to an embodiment of the present invention;
FIG. 5 is a schematic diagram of a cell separation system according to an embodiment of the present invention;
FIG. 6 is a schematic diagram of a computer device in an embodiment of the invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are some, but not all, embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
In one embodiment, as shown in fig. 1, a method for determining a positive pressure threshold of a pipeline is provided, which includes the following steps:
s10: receiving a pipe installation completion instruction of a target pipeline, and acquiring a normal pressure value of fluid in the target pipeline, wherein the output end of the fluid is communicated with outside air; the target pipeline comprises a pump and a plurality of pipe sections connected to two ends of the pump, and further comprises a pipeline panel and the like for fixedly mounting the pipe sections and the pump; the tube section and the tube panel of the target tube are required to be replaced frequently (for example, most of the tube sections and tube panels used in the cell separation system are disposable consumables and need to be replaced frequently). The material of the replaced pipe section, the replaced pipe panel and the like in the target pipeline may be changed compared with the material before replacement, so that the pipe installation completion instruction is generated after the pipe (such as the pipe section, the pipeline panel and the like) in the target pipeline is replaced and installed, or generated when the pipe of the target pipeline is installed for the first time, or generated by triggering when the pipeline negative pressure threshold is determined in the process of manually clicking the human-computer interface/process flow after the pipe is installed, for example, after at least part of the pipe in the target pipeline is replaced, the preset confirmation button is triggered, and the pipe installation completion instruction is generated. Understandably, the pipe installation completion instruction includes pipe replacement parameters corresponding to the replaced pipe, such as material, length, thickness and other size parameters of the pipe after replacement.
Wherein the process flow is a step/process flow in the cell treatment process.
Understandably, after receiving the tube installation completion instruction, controlling the output end (for example, the end connected with the centrifuge cup in the cell separation system) of the target pipeline to be communicated with the outside air, and enabling the tube inside the target pipeline to be in an aseptic environment through an aseptic air filter in a communicated path, at this time, because the output end is communicated with the outside air, the normal pressure value of the fluid in the target pipeline is the outside air pressure, and is equal to the atmospheric pressure in general, and when the outside environment changes, the normal pressure value also changes along with the change of the outside environment, so in this embodiment, the determination of the normal pressure value embodies the consideration of the external environment factors in the positive pressure threshold determination process. Further, in the present invention, all the pipe sections or pipes are in communication with the outside air, which means that the pipe sections or pipes are in communication with the outside air through the sterile air filter.
S20: performing a positive pressure measurement start operation on the target pipeline; wherein the purpose of the positive pressure measurement initiating operation is to: after the positive pressure measurement starting operation is performed, if the pump in the target pipeline is started, a positive pressure environment is formed in the fluid pipeline between the pump in the target pipeline and the output end, so that the positive pressure limit value which can be reached by the fluid in the fluid pipeline between the pump and the output end in a state that the pump is continuously started in the positive pressure environment is further measured.
In one embodiment, as shown in fig. 5, the target pipeline 11 comprises a first pipeline segment L1, a pump 111 and a second pipeline segment L2 connected in series; a first pressure sensor for measuring the pressure of the fluid in the second pipe section L2 is clamped on the second pipe section L2; the output end of the target pipeline 11 is arranged at one end of the second pipe segment L2 far away from the pump 111; the input end of the target pipeline 11 is arranged at one end of the first pipe segment L1 far away from the pump 111; further, a second pressure sensor for measuring the fluid pressure in the first pipe segment L1 is clamped on the first pipe segment L1; the pump 111 in the present invention preferably includes, but is not limited to, a peristaltic pump, and correspondingly, the activation of the pump 111 in the present invention may refer to the positive rotation activation of the peristaltic pump, so as to continuously drive the fluid in the first pipe segment L1 to flow into the second pipe segment L2. The second pressure sensor and the first pressure sensor 15 can respectively measure the fluid pressure analog signal corresponding to the position of the point in the first pipe section L1 and the second pipe section L2, and further convert the pressure analog signal into an ADC (analog to digital converter) pressure value through AD conversion (analog to digital conversion), and transmit the pressure analog signal to the controller 12. Understandably, in the present invention, when a pump, a centrifuge cup, a waste liquid bag of a target pipeline in a cell separation system and a pipe section among the pump, the centrifuge cup, the waste liquid bag and the three are replaced (for example, the material or the model is replaced), the generation of a pipe installation completion instruction of the target pipeline in the pipeline positive pressure threshold determination method is necessarily triggered.
Further, in step S10, the obtaining a normal pressure value of the fluid in the target pipeline, of which the output end is communicated with the outside air, includes: and measuring a pressure value of the fluid in the second pipe section communicated with the outside air through the first pressure sensor, and determining the measured pressure value of the fluid as a normal pressure value. That is, in a state where the pump is not started, the output end of the target pipeline (i.e., the end of the second pipe section away from the pump) is communicated with the outside air, at this time, the normal pressure value of the fluid in the target pipeline, which is measured by the first pressure sensor located on the second pipe section, is the outside air pressure, and is generally equal to the atmospheric pressure.
Further, the step S20, namely, the performing a positive pressure measurement starting operation on the target pipeline, includes: and controlling the output end of the target pipeline communicated with the outside air to be closed, and controlling the input end of the target pipeline to be communicated with the outside air, so that a positive pressure environment is formed in the second pipe section after the pump is started. Understandably, in this embodiment, the output end of the target line is closed (i.e. closed by closing the first control valve disposed at the end of the second pipe section remote from the pump), and the input end of the target line (i.e. the end of the first pipe section remote from the pump) is communicated with the outside air (the input end of the target line is communicated with the outside air through the sterile air filter), and at this time, when the pump is not started or is started, the air pressure value in the first pipe section of the target line is equal to the outside air pressure. But for the second pipe section, at the initial moment when the pump is not started, the air pressure value in the second pipe section is equal to the external air pressure; if the pump starts to start continuously (for example, the peristaltic pump rotates positively), the gas in the first pipe section is continuously driven to flow towards the second pipe section, at this time, because the output end of the target pipeline is closed, the gas in the second pipe section is more and more, and the second pipe section is continuously in a positive pressure state, so the second pipe section is in a positive pressure environment, and because of the influence of the positive pressure in the pipe, the second pipe section becomes thicker gradually, and it needs to be noted that at this time, the gas pressure value in the second pipe section is higher than the gas pressure value in the first pipe section.
Wherein, the input end can be used for liquid in the liquid bag to flow in, or the liquid flows into the liquid bag; the output end liquid can be used for liquid outflow in the target pipeline, or the outflow liquid flows back to the target pipeline after being processed.
S30: after a pump in the target pipeline is started, acquiring a positive pressure gas pressure value of the target pipeline within a preset safety duration and acquiring time thereof; the preset safe time duration can be set according to the sustainable blocking time duration that the centrifugal cup in the cell separation system can not be exploded after being blocked (for example, the preset safe time duration is set to be 0.7-0.9 times of the sustainable blocking time duration), so that the safety of the positive pressure threshold determined by the pipeline positive pressure threshold determining method is ensured. That is, in this embodiment, if the pump starts to start continuously, since the output end of the target pipeline is closed, the second pipe segment will be in the positive pressure environment, and then the positive pressure gas value in the positive pressure environment and the collection time corresponding to each collected positive pressure gas value need to be collected regularly or in real time within the preset safety duration, so as to further determine the positive pressure threshold according to the collected data.
Further, the step S30, namely, acquiring the positive pressure gas pressure value of the target pipeline within the preset safe time period and the acquisition time thereof after the pump in the target pipeline is started, includes:
controlling a pump in the target pipeline to start so that a positive pressure environment is formed in the second pipe section; that is, in this embodiment, if the pump in the target pipeline is controlled to be started (for example, the peristaltic pump is rotated forward), the started pump will continuously drive the gas in the first pipe segment to flow toward the second pipe segment, and at this time, the second pipe segment will be in a positive pressure environment because the output end of the target pipeline is closed.
And detecting the positive pressure gas pressure value of the fluid in the positive pressure environment of the second pipe section in real time or at regular time through the first pressure sensor. That is, because the second pipe section is in the positive pressure environment, and the pressure in this positive pressure environment continuously rises, therefore, under the influence of the intraductal positive pressure, the second pipe section can become thick gradually, and at this moment, regularly (the time interval is set for according to the demand) or in real time pass through first pressure sensor detects the positive pressure gas pressure value of fluid in the positive pressure environment of second pipe section and corresponding acquisition time. It should be noted that the pressure of the gas at positive pressure in the second pipe section will be higher than the pressure in the first pipe section (equal to the ambient air pressure).
And after the pump is started for a preset safety duration, the pump is closed, and all the positive pressure gas pressure values collected in the preset safety duration and the collection time corresponding to the positive pressure gas pressure values are recorded. That is, after the pump is started for the preset safety duration, the centrifugal cup in the cell separation system may have a risk of cup explosion, and therefore, at this time, the pump needs to be turned off first, and then the positive pressure threshold is further determined according to all the positive pressure gas pressure values collected within the recorded preset safety duration and the collection time corresponding to the positive pressure gas pressure values, so that the accuracy of the determined positive pressure threshold is improved while the safety of the positive pressure threshold determined by the pipeline positive pressure threshold determination method is ensured.
S40: and acquiring a pipe replacement parameter in the pipe installation completion instruction, and determining a positive pressure threshold value of the target pipeline according to the pipe replacement parameter, the positive pressure gas pressure value, the acquisition time and the normal pressure value. That is, in this step, the pipe replacement parameter may reflect the influence of the material of the pipe replacement on the positive pressure threshold (after the pipe replacement, the pipe replacement parameter is sent to the controller along with the pipe replacement instruction and stored in the database or the gas storage area for being called at any time), the normal pressure value reflects the influence of the external environment on the positive pressure threshold, and the positive pressure gas pressure value and the collecting time may represent the positive pressure variation trend that may actually occur in the second pipe section under the influence of the positive pressure gas pressure value and the collecting time, so that the positive pressure variation trend when the output end of the second pipe section is blocked and is in the positive pressure environment may be determined according to the above four (the pipe replacement parameter, the normal pressure value, the positive pressure gas pressure value and the collecting time), and then the positive pressure variation limit value corresponding to the variation trend is determined according to the variation trend, and determining a positive pressure threshold value according to the positive pressure change limit value.
Understandably, after step S40, the method further includes: and (3) closing the pump, namely stopping the rotation of the pump, and opening the first control valve at the output end to enable the second pipe section to be communicated with the outside air (or other pipe sections) so as to facilitate the subsequent cell separation treatment.
After the target pipeline receives a pipe installation completion instruction, at least part of pipes in the target pipeline are confirmed to be replaced, at the moment, positive pressure measurement starting operation is carried out on the target pipeline, so that a positive pressure environment is formed in a fluid pipeline between a pump and an output end of the target pipeline after the pump in the target pipeline is started, and further, a positive pressure threshold value of the target pipeline is automatically determined according to a normal pressure value measured before the pump is started, a positive pressure gas pressure value acquired after the pump is started, acquisition time of the positive pressure gas pressure value and the acquisition time of the positive pressure gas pressure value, and pipe replacement parameters corresponding to the replaced pipes. After each pipe replacement operation, the positive pressure threshold corresponding to the pipe replacement parameter can be accurately determined in a targeted manner by automatically combining with the outside air (external environment influence factors) and the pipe replacement parameter of the replaced pipe, the positive pressure threshold does not need to be manually set or adjusted, and the setting efficiency and accuracy of the positive pressure threshold are improved, so that the accuracy of warning the abnormity (such as blockage) of the cell separation process according to the automatically determined positive pressure threshold is ensured, and the cell separation process is further ensured to be smoothly carried out and the safety of the cell separation process is further ensured.
In an embodiment, as shown in fig. 2, the step S40, namely, the determining the positive pressure threshold of the target pipeline according to the pipe replacement parameter, the positive pressure gas value, the collecting time and the normal pressure value, includes:
s401, recording a difference value between each positive pressure gas pressure value acquired within the preset safe duration and the normal pressure value as a gas pressure difference, and associating each gas pressure difference with each acquisition time in a one-to-one correspondence manner; in this embodiment, the pressure difference between the positive pressure gas pressure value and the normal pressure value may be obtained, and then the obtained pressure difference and the acquisition time may be associated in a one-to-one correspondence manner under the condition of combining the normal pressure value (which represents the change of the positive pressure threshold value affected by the external environment) and the positive pressure gas pressure value (which represents the influence of the positive pressure threshold value affected by the material of the pipeline and the external environment, for example, the change of the pipe such as the second pipe section or the change of the external air pressure may cause the change of the positive pressure gas pressure value), and the subsequent step S402 is performed.
S402, determining a positive pressure threshold value of the target pipeline according to the pipe replacement parameters, the air pressure difference and the corresponding acquisition time. That is, the positive pressure threshold of the target pipeline can be further determined according to the pipe replacement parameters, the air pressure difference and the corresponding acquisition time. Further, as shown in fig. 3, the step S402 includes:
s4021, constructing a time-air pressure curve according to all the air pressure differences and the corresponding acquisition time; in the step, a time-air pressure rectangular coordinate system is firstly established, and then a time-air pressure curve is established in the time-air pressure rectangular coordinate system according to the air pressure differences corresponding to different acquisition times in all the preset safe time lengths. Further, the step S4021, namely, constructing a time-air pressure curve according to all the air pressure differences and the corresponding acquisition times, includes: performing data screening processing on all the air pressure differences to obtain interference data; the interference data comprises the air pressure difference exceeding a preset air pressure jumping range (set according to requirements) and the corresponding acquisition time; and after the interference data are deleted, constructing a time-air pressure curve according to all the remaining air pressure differences and the corresponding acquisition time. That is, before constructing the time-air pressure curve, the air pressure value with excessive data jitter is removed (that is, the air pressure value is subjected to data screening processing to remove interference data) so as to improve the accuracy of the finally obtained time-air pressure curve.
S4022, acquiring a parameter attribute value corresponding to a preset type linear parameter in the time-air pressure curve; that is, after the time-air pressure curve is constructed, the attribute values corresponding to one or more preset type linear parameters (such as a slope, a rising and falling trend, and the like) may be extracted from the time-air pressure curve, and a set of all the attribute values corresponding to the preset type linear parameters is the parameter attribute value.
S4023, a preset parameter-threshold value comparison table corresponding to the preset type linear parameter and the pipe replacement parameter is obtained, wherein the preset parameter-threshold value comparison table comprises a plurality of parameter value groups, and each parameter value group corresponds to a pressure limit value; that is, each preset parameter-threshold comparison table corresponds to one linear parameter type, and each preset parameter-threshold comparison table includes a plurality of sets of parameter values corresponding to the linear parameter types, and each set of parameter values is a parameter value (equal to the attribute value) corresponding to each linear parameter in the linear parameter type. Meanwhile, the pressure limit value corresponding to each parameter value group is obtained by performing a positive pressure test on a target pipeline corresponding to a group of pipe parameters (corresponding to the pipe replacement parameters), specifically, when performing a positive pressure test on different test pipelines (the test pipelines are pipelines consistent with the target pipeline after the pipe is replaced according to the pipe parameters), when pipe sections made of different materials are respectively arranged at the positions of a first pipe section or a second pipe section, different parameter value groups and multiple corresponding pressure limit values thereof can be obtained, the parameter value groups and the pressure limit values obtained by the positive pressure test are correspondingly associated with the pipe parameters, and further, a preset parameter-threshold value comparison table can be generated and stored for being adjusted at any time according to the mutually associated parameter value groups, pressure limit values, pipe parameters and linear parameter types.
In this embodiment, the preset parameter-threshold comparison table corresponding to the preset type linear parameter and the pipe replacement parameter is: the linear parameter type of the preset parameter-threshold comparison table is matched with the linear parameter of the preset type, and the pipe parameter of the preset parameter-threshold comparison table is matched with the pipe replacement parameter. Wherein, matching means consistent or fluctuating within a certain range.
S4024, determining the parameter value set matched with the parameter attribute value from the preset parameter-threshold comparison table; in this step, after a preset parameter-threshold comparison table corresponding to the preset type linear parameter and the pipe replacement parameter is retrieved, a parameter value group which is consistent with the parameter attribute value or fluctuates within a preset range may be queried from the comparison table.
S4025, determining the positive pressure threshold value of the target pipeline according to the pressure limit value corresponding to the parameter value set matched with the parameter attribute value. That is, after the parameter value group matching the parameter attribute value is determined, the pressure limit value associated with the determined parameter value group in the preset parameter-threshold value comparison table is determined as the positive pressure limit value that can be finally reached by the pressure change trend corresponding to the time-air pressure curve, and the positive pressure threshold value of the target pipeline can be determined according to the positive pressure limit value, for example, the positive pressure threshold value can be set to a certain proportion of the positive pressure limit value, such as between 0.8 and 1.
In an embodiment, the step S40, namely, the determining the positive pressure threshold of the target pipeline according to the pipe replacement parameter, the air pressure difference and the corresponding acquisition time includes:
inputting the pipe replacement parameters, all the air pressure differences and the corresponding acquisition time into a preset positive pressure threshold prediction model to obtain a predicted pressure threshold output by the preset positive pressure threshold prediction model; the preset positive pressure threshold prediction model is constructed on the basis of a neural network; that is, in this embodiment, the preset positive pressure threshold prediction model may be obtained by training historical positive pressure test data (the historical positive pressure test data includes historical trend change curves and historical positive pressure limit values corresponding to the historical trend change curves, and each historical trend change curve corresponds to a set of pipeline parameters) based on the neural network model, through the preset positive pressure threshold prediction model, the change trend characteristics of the input air pressure difference along with the acquisition time can be extracted, meanwhile, the preset positive pressure threshold prediction model can also determine all pipeline parameters corresponding to the pipe replacement parameters according to the pipe replacement parameters, further acquiring a historical trend change curve according to the determined pipeline parameters, further matching the extracted change trend characteristics with the acquired historical trend change curve, and when the matching is successful, outputting the historical positive pressure limit value corresponding to the history trend change curve which is successfully matched as the predicted pressure threshold value.
And determining a positive pressure threshold value of the target pipeline according to the predicted pressure threshold value. That is, in this embodiment, the predicted pressure threshold corresponds to the positive pressure limit value that can be finally reached by the pressure change trend corresponding to the current pipeline replacement, so the positive pressure threshold of the target pipeline can be determined according to the predicted pressure threshold, for example, the positive pressure threshold can be set to a certain proportion of the predicted pressure threshold, such as 0.8-1.
The invention also provides an abnormal warning method of the cell separation system, wherein the cell separation system comprises a target pipeline, a liquid bag communicated with the input end of the target pipeline and a centrifugal cup communicated with the output end of the target pipeline; a first pressure sensor is arranged between the centrifugal cup and the pump of the target pipeline; further, a second pressure sensor can be arranged between the liquid bag and the pump of the target pipeline; in this embodiment, the second pressure sensor is only required to be arranged on the fluid line between the fluid bag and the pump, and is not limited to be arranged on the first pipe section as long as the second real-time pressure value in the fluid line from the fluid bag to the pump can be measured. Similarly, the first pressure sensor may be disposed on the fluid line between the centrifugal cup and the pump, and need not be disposed on the second pipe section, as long as the first real-time pressure value in the fluid line from the pump to the centrifugal cup can be measured.
Further, as shown in fig. 4, the cell separation system abnormality warning method includes:
s100, determining a positive pressure threshold of a target pipeline in the cell separation system by the pipeline positive pressure threshold determination method; it should be clear that, the method for determining the positive pressure threshold of the pipeline in the invention needs to be performed before the cell separation system performs the cell separation process, that is, before the cell separation process needs to be performed, it is first monitored whether a pipe installation completion instruction of a target pipeline is received, and if the pipe installation completion instruction of the target pipeline is received, the positive pressure threshold of the target pipeline in the cell separation system is first determined by the method for determining the positive pressure threshold of the pipeline.
Understandably, in the method for determining the positive pressure threshold value of the pipeline, the step of closing the output end of the target pipeline means that the communication between the second pipeline section and the centrifugal cup is cut off through the first control valve, and the output end of the second pipeline section is blocked. In this embodiment, after the positive pressure threshold is determined in step S40, the method further includes turning off the pump, i.e., stopping the rotation of the pump, and re-opening the output end of the target pipeline, i.e., allowing the second pipe segment to return to the communication with the centrifuge cup (the liquid can flow from the liquid bag into the centrifuge cup through the fluid pipeline and the pump, and the pump is always rotating during the process of flowing the liquid in the liquid bag into the centrifuge cup), so as to facilitate the subsequent cell separation process; after the operation is completed, a trigger button for presetting the cell separation operation is triggered, and then a cell separation processing instruction is generated, and the subsequent steps are executed. Understandably, if the pipe installation completion instruction is not received before the cell separation processing is required, the trigger button for presetting the cell separation operation can be directly triggered, and then the subsequent steps are executed after the cell separation processing instruction is generated.
S200, receiving a cell separation processing instruction, controlling a pump of the target pipeline to start and execute cell separation operation, and monitoring a first real-time pressure value in a fluid pipeline between the centrifugal cup and the pump of the target pipeline through the first pressure sensor; the cell separation operation is set according to a specific operation flow required for the cell separation process, for example, a motor may be started to drive the centrifuge cup to rotate, and the like, which is not described herein again. After receiving a cell separation processing instruction and controlling the pump of the target pipeline to start and execute cell separation operation, monitoring a first real-time pressure value in a fluid pipeline between the pump of the target pipeline and a centrifugal cup in real time or at regular time (the time interval can be set according to requirements) through a first pressure sensor, and further determining whether abnormal warning needs to be carried out or not according to the first real-time pressure value.
S300, when the first real-time pressure value is larger than or equal to the positive pressure threshold value, controlling the pump to be closed, and prompting that the output end of the centrifugal cup or/and the target pipeline is abnormal through a first preset prompting mode.
Understandably, when the liquid bag is a blood sample bag and blood in the blood sample bag is not shaken evenly and blood clots occur, because the pump rotates all the time in the process that the blood in the blood sample bag flows into the centrifugal cup, when the blood in the blood sample bag flows into the centrifugal cup or the centrifugal cup injects cell separation liquid in the centrifugal process, a blockage occurs in a liquid inlet channel of the centrifugal cup or a liquid inlet is blocked in the centrifugal process of the centrifugal cup, because the pump rotates continuously, the blood which is pumped from the blood sample bag and enters the second pipe section cannot flow into the centrifugal cup, but the pump rotates continuously and continues to pump the blood in the blood sample bag into the second pipe section, therefore, a liquid pipeline between the pump and the centrifugal cup (the blockage corresponding to a waste liquid bag can also feed back into the pipeline) becomes thicker gradually due to the gradual increase of the pressure in the pipe, namely, a first real-time pressure value measured by the first pressure sensor has a positive pressure and a rising tendency, at this time, when the first real-time pressure value measured by the first pressure sensor is greater than or equal to the positive pressure threshold value, it is determined that the output end of the centrifuge cup or/and the target pipeline is abnormal (the blockage of the centrifuge cup may cause cup explosion, thereby the whole centrifuge cup is unusable and the blood sample is polluted, the blockage of the waste liquid bag causes the unnecessary liquid component to be discharged smoothly, the next operation cannot be performed at this time, the cell separation operation time is wasted, the blockage of the centrifuge cup and the waste liquid bag is the abnormal blockage problem of the output end of the centrifuge cup or/and the target pipeline), the output end of the centrifugal cup or/and the target pipeline can be prompted to be abnormal in a first preset prompting mode, for example, images, characters and other prompts are displayed on a preset display interface, or the prompt can be carried out by playing sound prompt or by lights with different colors or flashing frequencies; in a specific embodiment, the prompt message may be set as "abnormal tube pressure at the output end of the centrifugal cup or/and the target pipeline: the positive pressure exceeds the standard or the centrifugal cup is blocked by liquid inlet, and the like. After the abnormity warning is carried out, when cell separation is carried out, the current cell separation operation can be stopped according to the prompt information, the problems that the centrifugal cup is exploded, the blood sample is polluted or the next operation cannot be carried out and the like due to the blockage of the centrifugal cup, the waste liquid bag or the output end can be solved, and meanwhile, after the blockage state (such as a new pipeline and the like) is relieved according to the received prompt information, the step S100 and the subsequent steps are executed again, so that the safety accident is avoided, and the cell separation efficiency is also improved.
In one embodiment, a second pressure sensor is arranged between the liquid bag and the pump of the target pipeline; further, after the pump in the target pipeline is started, the cell separation system abnormality warning method further includes:
monitoring, by the second pressure sensor, a second real-time pressure value in a fluid line between the fluid bag and a pump of the target line; thus, a second real-time pressure value in the fluid line between the fluid bag and the pump may be measured by the second pressure sensor in real-time or timed.
And acquiring a negative pressure threshold value of a target pipeline in the cell separation system, controlling the pump to be closed when the second real-time pressure value is less than or equal to the negative pressure threshold value, and prompting that the input end of the liquid bag or/and the target pipeline is abnormal in a second preset prompting mode. That is, in this embodiment, the negative pressure threshold may be obtained first, wherein the negative pressure threshold may be determined according to a predetermined pipeline negative pressure threshold determination method, or may be preset.
In one embodiment, after the illustrated step S10, a preset line negative pressure threshold determination method may be performed to obtain the negative pressure threshold, the preset line negative pressure threshold determination method including:
the method comprises the following steps: performing negative pressure measurement starting operation on the target pipeline; wherein the purpose of the negative pressure measurement start operation is: after the negative pressure measurement starting operation is performed, if the pump in the target pipeline is started, a negative pressure environment is formed in the target pipeline so as to further measure a negative pressure limit value which can be reached by the fluid in the target pipeline in a state that the pump is started in the negative pressure environment.
The executing negative pressure measurement starting operation on the target pipeline specifically comprises:
controlling the second pressure sensor to disengage from the first pipe segment to release the first pipe segment; that is, in the present invention, the above-mentioned abnormal warning for the cell separation process of the cell separation system according to the negative pressure threshold mainly occurs in the first pipe segment, and therefore, in the present invention, the second pressure sensor clamped on the first pipe segment is controlled to be separated from the first pipe segment, that is, at this time, the measurement clamping portion corresponding to the second pressure sensor does not clamp the first pipe segment any more, and therefore, the first pipe segment is released freely, and deformation and the like due to clamping of the measurement clamping portion are avoided, so that the fluid in the first pipe segment which is not deformed can flow more freely, and further, the measurement accuracy of the whole measurement process of the negative pressure threshold is higher.
And sealing the input end of the target pipeline, and keeping the output end of the target pipeline communicated with the outside air, so that a negative pressure environment is formed in the first pipe section and the second pipe section after the pump is started. Understandably, in this embodiment, the input end of the target pipeline is closed (i.e. closed by closing the second control valve arranged at the end of the first pipe section far away from the pump), the output end of the target pipeline (i.e. the end of the second pipe section far away from the pump) is communicated with the outside air (the output end of the target pipeline is communicated with the outside air through the sterile air filter), and at the initial moment when the pump is not started, the air pressure value in the target pipeline is equal to the outside air pressure; if the pump starts to be continuously started (for example, the peristaltic pump rotates forwards), the gas in the first pipe section is continuously driven to flow towards the second pipe section, at this time, because the input end of the target pipeline is closed, the gas in the first pipe section is less and is continuously in the negative pressure state, meanwhile, because the gas which is driven by the pump to enter the second pipe section from the first pipe section is less and less, the second pipe section is also influenced and is continuously in the negative pressure state, so that the whole target pipeline is in the negative pressure environment, and because of the influence of the negative pressure in the pipe, the first pipe section and the second pipe section are both tapered, and it needs to be noted that the gas pressure value in the first pipe section is lower than the gas pressure value in the second pipe section.
Step two: after a pump in the target pipeline is started, if the pressure of fluid in the target pipeline meets a preset negative pressure constant condition, acquiring a negative pressure comparison value of the target pipeline; understandably, the condition that the fluid pressure in the target pipeline meets the preset negative pressure constant condition refers to that: the whole target pipeline is in a negative pressure environment, and the pressure in the corresponding negative pressure environment in the target pipeline is continuously reduced, so that under the influence of the negative pressure in the pipeline, the first pipeline section and the second pipeline section are tapered, when the negative pressure detected by the first pressure sensor is not changed or is almost unchanged, the negative pressure in the target pipeline reaches a limit value, at the moment, the fluid pressure in the target pipeline is considered to meet a preset negative pressure constant condition, and then the negative pressure gas pressure value correspondingly collected by the first pressure sensor when the preset negative pressure constant condition is met can be obtained, the negative pressure gas pressure value is a negative pressure comparison value, the negative pressure comparison value represents the negative pressure limit which can be reached in the second pipeline section, and understandably, after the second pipeline section reaches the negative pressure limit, the negative pressure limit is also reached in the first pipeline section.
In the second step, after the pump in the target pipeline is started, a negative pressure environment is formed in the first pipe section and the second pipe section; detecting the negative pressure gas pressure value of the fluid in the negative pressure environment of the second pipe section in real time or at regular time through the second pressure sensor; and if the difference value between the maximum value and the minimum value of all the negative pressure gas pressure values in a preset historical time length before the current time point (the preset historical time length can be set according to requirements) is smaller than a preset fluctuation range, determining that the negative pressure gas pressure values meet a preset negative pressure constant condition. That is, when the maximum fluctuation range of the negative pressure gas pressure value within the preset historical duration is smaller than the preset fluctuation range, it indicates that the negative pressure gas pressure value has fallen to a constant value or is almost constant, and at this time, it indicates that the negative pressure gas pressure value in the target pipeline reaches the limit value, and the subsequent variation amplitude of the negative pressure gas pressure value in this state will be negligible, and at this time, it is considered that the fluid pressure in the target pipeline satisfies the preset constant negative pressure condition. And then, when the negative pressure gas pressure value meets a preset negative pressure constant condition, closing the pump, and recording the currently measured negative pressure gas pressure value as a negative pressure comparison value, wherein the negative pressure comparison value is smaller than the normal pressure value.
Step three: and acquiring a pipe replacement parameter in the pipe installation completion instruction, and determining a negative pressure threshold value of the target pipeline according to the pipe replacement parameter, the normal pressure value, the negative pressure comparison value and a preset negative pressure threshold value model. That is, in this step, the pipe replacement parameter can reflect the influence of the material for pipe replacement on the negative pressure threshold, the normal pressure value reflects the influence of the external environment on the negative pressure threshold, and the negative pressure comparison value is the negative pressure limit that can be reached in the second pipe section under the influence of the above two values, so that the negative pressure threshold that reflects the negative pressure limit in the first pipe section can be obtained according to the above three values (the pipe replacement parameter, the normal pressure value, and the negative pressure comparison value) and the preset negative pressure threshold model. It should be understood that the negative pressure threshold value is not necessarily a negative pressure gas pressure value directly corresponding to the first pipe section when the negative pressure limit is reached, and may be a safe negative pressure threshold value obtained by performing safe setting based on the negative pressure gas pressure value corresponding to the negative pressure limit.
In one embodiment, the preset negative pressure threshold model is:
Y＝k1*k2*(A-B)
wherein:
y is the negative pressure threshold; understandably, Y is a negative value.
k1 is a pressure safety factor; preferably, K1 can be 0.8 to 1.
K2 is the pressure correlation coefficient; the pressure correlation coefficient between the first pipe section and the second pipe section after the target pipeline is changed into the pipe can be determined according to the pipe change parameters; that is, the pipe replacement parameter can reflect the influence of the material of the pipe replacement on the negative pressure threshold, when the pipe sections made of different materials are respectively arranged at the positions of the first pipe section or the second pipe section, different pressure correlation coefficients between the first pipe section and the second pipe section can be obtained, and then, according to the pressure correlation coefficients, the corresponding negative pressure comparison value of the second pipe section under the negative pressure limit (when the fluid pressure in the target pipeline meets the preset constant negative pressure condition) can be mapped to the first pipe section, so that the negative pressure limit value corresponding to the first pipe section is obtained. The pressure correlation coefficient may be obtained in advance by performing a pressure test on different test pipelines (a test pipeline is a pipeline that is consistent with a target pipeline after a pipe is replaced according to the pipe replacement parameter), the obtained pressure correlation coefficient may be associated with the pipe replacement parameter to generate a comparison table, and in this step, the pressure correlation coefficient corresponding to the pipe replacement parameter may be queried from the comparison table. Further, K2 may be 0.8-0.9. Preferably, k1 × k2 is 0.7.
A is the negative pressure comparison value; the negative pressure comparison value is a negative pressure gas pressure value collected by the second pressure sensor in the second pipe section when the fluid pressure in the target pipeline meets a preset negative pressure constant condition, and the negative pressure comparison value reflects the negative pressure limit which can be reached in the second pipe section; the negative pressure comparison value A is smaller than the normal pressure value B.
And B is the normal pressure value. It should be understood that, in this embodiment, the setting of the state and the condition of obtaining the normal pressure value represents the consideration of the external environmental factors in the negative pressure threshold determination process.
Understandably, after the third step, the method further comprises the following steps: and closing the pump, namely stopping the rotation of the pump, opening a second control valve for closing the input end of the target pipeline, allowing the first pipeline section to be communicated with the outside air (or other pipeline sections), and clamping the second pressure sensor on the first pipeline section again, so that the first pipeline section is positioned at the measurable position of the second pressure sensor again to facilitate the subsequent cell separation treatment.
According to the embodiment of the invention, after each pipe replacement operation, the negative pressure threshold value corresponding to the outside air (outside environment influence factor) and the pipe replacement parameter of the replaced pipe can be automatically and accurately determined in a targeted manner without manually setting or adjusting the negative pressure threshold value, so that the setting efficiency and accuracy of the negative pressure threshold value are improved, the accuracy of abnormal warning of the cell separation process according to the automatically determined negative pressure threshold value is ensured, and the cell separation process is further ensured to be smoothly carried out and the safety of the cell separation process is ensured.
Understandably, when the liquid bag is a blood sample bag and blood in the blood sample bag is not shaken uniformly, a blood clot occurs, and the liquid outlet of the blood sample bag or a pipeline (or/and a pipeline panel) near the liquid outlet is blocked, because the pump is always rotating in the process of flowing the blood in the blood sample bag into the centrifugal cup, at this time, if the blockage causes that the blood in the fluid pipeline between the blood sample bag and the pump cannot flow, the pressure in the fluid pipeline between the blood sample bag and the pump gradually decreases, at this time, the pump continues to rotate to form a negative pressure environment, and when a second real-time pressure value monitored by the second pressure sensor is smaller than or equal to a negative pressure threshold value, it is determined that the blood sample bag or/and the input end of the target pipeline are abnormal, at this time, the blood sample bag or/and the target pipeline may be prompted in a second preset prompting manner (the second preset prompting manner may be the same as or different from the first preset prompting manner) to prompt the blood sample bag or/and/or the blood sample bag and/or the target pipeline When the input end of the target pipeline is abnormal, for example, prompts such as images and characters are displayed on a preset display interface, or prompts can be given by playing sound, or prompts can be given by lights with different colors or flashing frequencies; in a specific embodiment, the prompt message may be set as "abnormal pressure in the blood sample bag or/and the target line: negative pressure exceeds standard or the blood sample bag or the pipeline panel is blocked, and the like. After the abnormal warning is performed, when the cell separation is performed, the whole machine can not run idle due to the blockage of the blood sample bag or the input end, and the cell separation operation can not be performed normally (the cell separation operation time is wasted), but the current cell separation operation can be stopped according to the prompt information, and after the blockage state is removed (for example, a new blood sample bag is replaced, a blocked pipeline is replaced, and the like), the cell separation operation is returned to the step S100 and the subsequent steps, so that the occurrence of safety accidents is avoided, and the cell separation efficiency is also improved.
Understandably, in the above example, when the blood sample bag and the centrifuge cup are blocked during the process of flowing into the centrifuge cup, the fluid pipeline between the blood sample bag and the pump becomes thinner and thinner due to the decreasing pressure in the tube as the pump continues to rotate forward, i.e. the second real-time pressure value in the first tube section measured by the second pressure sensor has a tendency of negative pressure and decreasing. Fluid pipeline between pump and the centrifugal cup is thick gradually because intraductal pressure crescent, the real-time pressure value of second that first pressure sensor surveyed has the trend of malleation and rising promptly, under the pump continues the pivoted condition, if the real-time pressure value of first that second pressure sensor surveyed is less than or equal to the negative pressure threshold value, and when the real-time pressure value of second that first pressure sensor surveyed was greater than or equal to the malleation threshold value, think blood sample bag and centrifugal cup all appear unusually, at this moment, can predetermine the suggestion mode through first preset mode or/and second and remind, the suggestion information can be for "the intraductal pressure is unusual: the positive/negative pressure exceeds the standard or the blood sample bag is blocked and the centrifugal cup is blocked by liquid inlet, etc.
In the embodiment of the invention, the negative pressure threshold value and/or the positive pressure threshold value of the target pipeline in the cell separation system can be determined firstly, and then after each pipe replacement operation, the negative pressure threshold value and/or the positive pressure threshold value corresponding to the negative pressure threshold value and/or the positive pressure threshold value can be accurately determined in a targeted manner by automatically combining with the external air (external environment influence factors) and the pipe replacement parameters of the replaced pipe, so that the setting efficiency and the accuracy of the negative pressure threshold value and/or the positive pressure threshold value are improved without manually setting or adjusting the negative pressure threshold value and/or the positive pressure threshold value, and thus, the accuracy of abnormal warning of the cell separation process according to the automatically determined negative pressure threshold value and/or positive pressure threshold value is ensured, and the cell separation process is further ensured to be carried out smoothly and the safety thereof.
It should be understood that, the sequence numbers of the steps in the foregoing embodiments do not imply an execution sequence, and the execution sequence of each process should be determined by functions and internal logic of the process, and should not limit the implementation process of the embodiments of the present invention in any way.
In one embodiment, a positive pipeline pressure threshold value determining device is provided, and the positive pipeline pressure threshold value determining device corresponds to the positive pipeline pressure threshold value determining method in the above embodiments one to one. The positive pressure threshold determination device for a pipeline comprises:
the receiving module is used for receiving a pipe installation completion instruction of a target pipeline and acquiring a normal pressure value of fluid in the target pipeline, wherein the output end of the fluid is communicated with the outside air;
the operation module is used for executing positive pressure measurement starting operation on the target pipeline;
the acquisition module is used for acquiring the positive pressure gas pressure value and the acquisition time of the target pipeline within a preset safety duration after the pump in the target pipeline is started;
and the determining module is used for acquiring a pipe replacing parameter in the pipe installation completion instruction and determining a positive pressure threshold value of the target pipeline according to the pipe replacing parameter, the positive pressure gas pressure value, the acquisition time and the normal pressure value.
For specific definition of the positive pressure threshold determination device, reference may be made to the above definition of the positive pressure threshold determination method, and details are not repeated here. The modules in the positive line pressure threshold determination device can be implemented in whole or in part by software, hardware and a combination thereof. The modules can be embedded in a hardware form or independent of a processor in the computer device, and can also be stored in a memory in the computer device in a software form, so that the processor can call and execute operations corresponding to the modules.
In one embodiment, an abnormality warning device for a cell separation system is provided, wherein the abnormality warning device for a cell separation system corresponds to the abnormality warning methods for a cell separation system in the above embodiments one to one. The cell separation system abnormality warning device includes:
a determining unit for determining a positive pressure threshold of a target line in the cell separation system by the line positive pressure threshold determining method;
the control unit is used for receiving a cell separation processing instruction, controlling the pump of the target pipeline to start and execute cell separation operation, and monitoring a first real-time pressure value in a fluid pipeline between the centrifugal cup and the pump of the target pipeline through the first pressure sensor;
and the prompting unit is used for controlling the pump to be closed when the first real-time pressure value is greater than or equal to the positive pressure threshold value, and prompting that the output end of the centrifugal cup or/and the target pipeline is abnormal through a first preset prompting mode.
For the specific limitation of the cell separation system abnormality warning device, reference may be made to the above-mentioned limitation on the cell separation system abnormality warning method, which is not described herein again. All or part of the modules in the cell separation system abnormality warning device can be realized by software, hardware and a combination thereof. The modules can be embedded in a hardware form or independent from a processor in the computer device, and can also be stored in a memory in the computer device in a software form, so that the processor can call and execute operations corresponding to the modules.
The invention also provides a controller, which is used for executing the pipeline positive pressure threshold value determining method or the cell separation system abnormity warning method. For specific limitations of the controller, reference may be made to the above limitations of the method for determining the positive pressure threshold of the pipeline and the method for warning the abnormality of the cell separation system, which are not described herein again. The various modules in the controller described above may be implemented in whole or in part by software, hardware, and combinations thereof. The modules can be embedded in a hardware form or independent from a processor in the computer device, and can also be stored in a memory in the computer device in a software form, so that the processor can call and execute operations corresponding to the modules. Understandably, the controller can be viewed as one or more computer devices, as shown in FIG. 6, which include a processor, memory, network interface, and database connected by a system bus. Wherein the processor of the computer device is configured to provide computing and control capabilities. The memory of the computer device comprises a nonvolatile storage medium and an internal memory. The non-volatile storage medium stores an operating system, a computer program, and a database. The internal memory provides an environment for the operating system and the computer program to run on the non-volatile storage medium. The database of the computer device is used for storing data used in the method for determining the positive pressure threshold of the pipeline or the method for warning the abnormality of the cell separation system in the embodiment. The network interface of the computer device is used for communicating with an external terminal through a network connection. The computer program is executed by a processor to implement a method for determining a positive pressure threshold in a pipeline or a method for warning an abnormality in a cell separation system.
As shown in fig. 5, the present invention further provides a cell separation system, which includes a target pipeline 11, a liquid bag 13 communicated with an input end of the target pipeline 11, a centrifuge cup 14 communicated with an output end of the target pipeline 11, and the controller 12, wherein a first pressure sensor 15 is disposed between the centrifuge cup 14 and a pump 111 of the target pipeline 11; a second real-time pressure value in the fluid line from the pump 111 to the centrifuge cup 14 can be measured by means of the first pressure sensor 15. The controller 12 communicates the first pressure sensor 15 and the pump 111. Further, a second pressure sensor is arranged between the liquid bag 13 and the pump 111 of the target pipeline 11; the controller 12 is also in communication with the second pressure sensor. For more specific limitations of the cell separation system and the controller, reference may be made to the above-mentioned limitations of the positive pressure threshold determination method for the pipeline and the above-mentioned abnormality warning method for the cell separation system, which are not described herein again.
In one embodiment, a computer-readable storage medium is provided, which stores a computer program, wherein the computer program is executed by a processor to implement the method for determining a positive pressure threshold in a pipeline, or the computer program is executed by a processor to implement the method for warning an abnormality in a cell separation system.
It will be understood by those skilled in the art that all or part of the processes of the methods of the embodiments described above can be implemented by hardware instructions of a computer program, which can be stored in a non-volatile computer-readable storage medium, and when executed, can include the processes of the embodiments of the methods described above. Any reference to memory, storage, database, or other medium used in the embodiments provided herein may include non-volatile and/or volatile memory, among others. Non-volatile memory can include read-only memory (ROM), Programmable ROM (PROM), Electrically Programmable ROM (EPROM), Electrically Erasable Programmable ROM (EEPROM), or flash memory. Volatile memory can include Random Access Memory (RAM) or external cache memory. By way of illustration and not limitation, RAM is available in a variety of forms such as Static RAM (SRAM), Dynamic RAM (DRAM), Synchronous DRAM (SDRAM), Double Data Rate SDRAM (DDRSDRAM), Enhanced SDRAM (ESDRAM), Synchronous Link DRAM (SLDRAM), Rambus Direct RAM (RDRAM), direct bus dynamic RAM (DRDRAM), and memory bus dynamic RAM (RDRAM).
It will be apparent to those skilled in the art that, for convenience and brevity of description, only the above-mentioned division of the functional units and modules is illustrated, and in practical applications, the above-mentioned function distribution may be performed by different functional units and modules according to needs, that is, the internal structure of the apparatus is divided into different functional units or modules to perform all or part of the above-mentioned functions.
The above-mentioned embodiments are only used for illustrating the technical solutions of the present invention, and not for limiting the same; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; such modifications and substitutions do not substantially depart from the spirit and scope of the embodiments of the present invention, and are intended to be included within the scope of the present invention.

Claims (12)

1. A method for determining a positive pressure threshold in a pipeline, comprising:
receiving a pipe installation completion instruction of a target pipeline, and acquiring a normal pressure value of fluid in the target pipeline, wherein the output end of the fluid is communicated with outside air;
performing a positive pressure measurement start operation on the target pipeline;
after a pump in the target pipeline is started, acquiring a positive pressure gas pressure value of the target pipeline within a preset safety duration and acquiring time thereof;
and acquiring a pipe replacement parameter in the pipe installation completion instruction, and determining a positive pressure threshold value of the target pipeline according to the pipe replacement parameter, the positive pressure gas pressure value, the acquisition time and the normal pressure value.
2. The method of determining a positive pressure threshold for a pipeline of claim 1, wherein said determining a positive pressure threshold for the target pipeline from the pipe change parameter, the positive pressure gas pressure value, the acquisition time, and the normal pressure value comprises:
recording the difference value between each positive pressure gas pressure value and the normal pressure value acquired in the preset safety duration as a gas pressure difference, and associating each gas pressure difference with each acquisition time in a one-to-one correspondence manner;
and determining the positive pressure threshold value of the target pipeline according to the pipe replacement parameters, the air pressure difference and the corresponding acquisition time.
3. The method for determining the positive pressure threshold value of the pipeline according to claim 2, wherein the step of determining the positive pressure threshold value of the target pipeline according to the pipe replacement parameter, the air pressure difference and the corresponding acquisition time comprises the following steps:
constructing a time-air pressure curve according to all the air pressure differences and the corresponding acquisition time;
acquiring a parameter attribute value corresponding to a preset type linear parameter in the time-air pressure curve;
a preset parameter-threshold comparison table corresponding to the preset type linear parameter and the pipe replacement parameter is obtained, the preset parameter-threshold comparison table comprises a plurality of parameter value groups, and each parameter value group corresponds to a pressure limit value;
determining the parameter value set matched with the parameter attribute value from the preset parameter-threshold comparison table;
and determining the positive pressure threshold value of the target pipeline according to the pressure limit value corresponding to the parameter value set matched with the parameter attribute value.
4. The method for determining a positive pressure threshold in a pipeline according to claim 3, wherein the step of constructing a time-air pressure curve according to all the air pressure differences and the corresponding acquisition times comprises:
performing data screening processing on all the air pressure differences to obtain interference data; the interference data comprises the air pressure difference exceeding a preset air pressure jumping range and the corresponding acquisition time;
and after the interference data are deleted, constructing a time-air pressure curve according to all the residual air pressure differences and the corresponding acquisition time.
5. The positive line pressure threshold determination method of claim 1, wherein the target line includes a first pipe segment, a pump, and a second pipe segment connected in series; a first pressure sensor for measuring the pressure of fluid in the second pipe section is clamped on the second pipe section; the output end of the target pipeline is arranged at one end of the second pipeline section far away from the pump; the input end of the target pipeline is arranged at one end of the first pipe section, which is far away from the pump;
the performing a positive pressure measurement initiating operation on the target pipeline includes:
and controlling the output end of the target pipeline communicated with the outside air to be closed, and controlling the input end of the target pipeline to be communicated with the outside air, so that a positive pressure environment is formed in the second pipe section after the pump is started.
6. The method of determining a positive line pressure threshold of claim 5, wherein said obtaining a normal pressure value of fluid in said target line having an output in communication with ambient air comprises:
and measuring a pressure value of the fluid in the second pipe section communicated with the outside air through the first pressure sensor, and determining the measured pressure value of the fluid as a normal pressure value.
7. The method for determining the positive pressure threshold value of the pipeline according to claim 5, wherein the step of acquiring the positive pressure gas pressure value of the target pipeline within a preset safety time period and the acquisition time thereof after the pump in the target pipeline is started comprises the following steps:
controlling a pump in the target pipeline to start so that a positive pressure environment is formed in the second pipe section;
detecting a positive pressure gas pressure value of the fluid in the positive pressure environment of the second pipe section in real time or at regular time through the first pressure sensor;
and after the pump is started for a preset safety duration, the pump is closed, and all the positive pressure gas pressure values collected in the preset safety duration and the collection time corresponding to the positive pressure gas pressure values are recorded.
8. The cell separation system abnormity warning method is characterized in that the cell separation system comprises a target pipeline, a liquid bag communicated with the input end of the target pipeline and a centrifugal cup communicated with the output end of the target pipeline; a first pressure sensor is arranged between the centrifugal cup and the pump of the target pipeline;
the cell separation system abnormity warning method comprises the following steps:
determining a positive pressure threshold value of a target line in a cell separation system by the line positive pressure threshold value determination method according to any one of claims 1 to 7;
receiving a cell separation processing instruction, controlling a pump of the target pipeline to start and execute cell separation operation, and monitoring a first real-time pressure value in a fluid pipeline between the centrifugal cup and the pump of the target pipeline through the first pressure sensor;
and when the first real-time pressure value is larger than or equal to the positive pressure threshold value, controlling the pump to be closed, and prompting that the output end of the centrifugal cup or/and the target pipeline is abnormal through a first preset prompting mode.
9. The method for warning abnormality in a cell separation system according to claim 8, wherein a second pressure sensor is provided between the liquid bag and the pump of the target line;
after the pump in the target pipeline is started, the cell separation system abnormity warning method further comprises the following steps:
monitoring, by the second pressure sensor, a second real-time pressure value in a fluid line between the fluid bag and a pump of the target line;
and acquiring a negative pressure threshold value of a target pipeline in the cell separation system, controlling the pump to be closed when the second real-time pressure value is less than or equal to the negative pressure threshold value, and prompting that the input end of the liquid bag or/and the target pipeline is abnormal in a second preset prompting mode.
10. A controller for performing the method of determining a positive line pressure threshold according to any one of claims 1 to 7 or the method of warning an abnormality in a cell separation system according to claim 8 or 9.
11. A cell separation system comprising a target line, a fluid bag in communication with an input end of the target line, a centrifuge cup in communication with an output end of the target line, and the controller of claim 9, wherein a first pressure sensor is disposed between the centrifuge cup and a pump of the target line; the controller communicates the first pressure sensor and the pump.
12. A computer-readable storage medium, in which a computer program is stored, which computer program, when being executed by a processor, carries out a method for determining a positive pressure threshold value in a line according to any one of claims 1 to 7, or which computer program, when being executed by a processor, carries out a method for warning an abnormality in a cell separation system according to claim 8 or 9.
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