CN115068732B - Infusion tube with PET-based Janus membrane for preventing blood backflow - Google Patents
Infusion tube with PET-based Janus membrane for preventing blood backflow Download PDFInfo
- Publication number
- CN115068732B CN115068732B CN202210526487.1A CN202210526487A CN115068732B CN 115068732 B CN115068732 B CN 115068732B CN 202210526487 A CN202210526487 A CN 202210526487A CN 115068732 B CN115068732 B CN 115068732B
- Authority
- CN
- China
- Prior art keywords
- membrane
- pet
- hydrophobic
- film
- hydrophilic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/165—Filtering accessories, e.g. blood filters, filters for infusion liquids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D17/00—Separation of liquids, not provided for elsewhere, e.g. by thermal diffusion
- B01D17/02—Separation of non-miscible liquids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D67/00—Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
- B01D67/0002—Organic membrane manufacture
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
- B01D69/10—Supported membranes; Membrane supports
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
- B01D69/12—Composite membranes; Ultra-thin membranes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
- B01D71/06—Organic material
- B01D71/30—Polyalkenyl halides
- B01D71/32—Polyalkenyl halides containing fluorine atoms
- B01D71/36—Polytetrafluoroethene
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
- B01D71/06—Organic material
- B01D71/72—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, not provided for in a single one of the groups B01D71/46 - B01D71/70 and B01D71/701 - B01D71/702
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/165—Filtering accessories, e.g. blood filters, filters for infusion liquids
- A61M2005/1657—Filter with membrane, e.g. membrane, flat sheet type infusion filter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/02—General characteristics of the apparatus characterised by a particular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/75—General characteristics of the apparatus with filters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2207/00—Methods of manufacture, assembly or production
Abstract
The invention discloses a transfusion tube with a PET-based Janus membrane for preventing blood backflow, which is characterized in that a filter (6) with the performance of the PET-based Janus membrane is connected to a traditional transfusion tube. The filter (6) consists of an upper joint (4), a backflow preventing film (3) and a lower joint (5). The backflow prevention film (3) is arranged between the upper joint (4) and the lower joint (5). The backflow prevention film (3) consists of a B hydrophobic transition layer (12), a C hydrophobic transition layer (13) and a B hydrophilic surface layer (2B). When the liquid is completely infused in the infusion process of the filter (6), the filter (6) can prevent the problem of blood backflow due to the fact that the venous pressure of a human body is larger than the liquid pressure in the infusion tube, so that the occurrence of medical accidents is reduced.
Description
Technical Field
The invention relates to the technical field of functional materials and fluid control, in particular to a novel PET-based Janus membrane infusion tube formed by connecting a filter with PET-based Janus membrane performance in a traditional infusion tube, which can solve the problem of blood backflow caused by untimely treatment when liquid is infused quickly.
Background
Infusion therapy is a medical technique that delivers liquids, drugs and nutrients directly into the veins, and can treat serious or chronic diseases and infections where oral antibiotics are ineffective, and is critical to human health. However, conventional tubing lacks a simple and effective anti-reflux design and blood reflux due to venous pressure greater than the fluid pressure within the tubing is likely to occur at the end of the infusion. If the treatment is not timely, the returned blood is liable to cause the formation of blood clots, resulting in medical accidents. The existing transfusion backflow prevention device mostly utilizes a mechanical spring or a metal ball to realize backflow, and has the defects of complex design, difficult preparation, unfriendly biology and the like.
Disclosure of Invention
In the traditional transfusion process, the transfusion tube lacks an effective backflow prevention design, and when transfusion is finished, the phenomenon that blood flows back into the transfusion tube easily occurs due to untimely treatment. Aiming at the problem that blood reflux is easy to occur when transfusion is finished and not timely treated, the invention designs a novel infusion tube with a PET-based Janus membrane for preventing blood reflux, and a PET-based Janus membrane filter (6) is connected to a traditional infusion tube. The filter (6) does not affect the normal infusion process, but prevents blood backflow towards the end of infusion. The filter (6) has a liquid diode effect. The existing transfusion backflow prevention device mostly utilizes a mechanical spring or a metal ball to realize backflow, and has the defects of complex design, difficult preparation, unfriendly biology and the like. The invention can prevent the blood backflow during transfusion by only using the PET-based Janus membrane filter (6), and has simple design and construction.
The second purpose of the invention is to provide a preparation method of the anti-reflux film 3 with PET-based Janus film performance, the prepared anti-reflux film 3 consists of a B hydrophobic transition layer (12), a C hydrophobic transition layer (13) and a B hydrophilic surface layer (2B), and the anti-reflux film 3 has a multilayer structure. The backflow prevention film (3) has good biological friendliness and does not cause any harm to human bodies.
The third object of the invention is to assemble the backflow prevention film (3) of the invention into a filter (6) with PET-based Janus film properties. The filter (6) acquires the property of Janus membrane by its unique liquid one-way permeability that liquid can spontaneously permeate from the hydrophobic side to the hydrophilic side in the forward direction, but cannot permeate from the hydrophilic side to the hydrophobic side in the reverse direction.
The invention relates to a preparation method of a PET-based Janus film performance backflow prevention film, which comprises the following steps:
step one, a modification process from a hydrophobic membrane to a hydrophilic membrane;
completely dissolving the weighed dopamine in Tris-HCl buffer solution by utilizing magnetic stirring to prepare a dopamine hydrochloride mixed solution;
the dopamine hydrochloride mixed solution is formed by adding 0.15 g-0.25 g of dopamine into 100mL of Tris-HCl buffer solution;
the concentration of Tris-HCl buffer is 1mol/L, and the pH value is 8.5;
placing the multi-layer PTFE/PET composite hydrophobic filter membrane (1) into the dopamine hydrochloride mixed solution prepared in the step 11;
mechanically stirring for 16-18 h at 20-40 ℃ to enable dopamine to undergo self-polymerization on the membrane surface to form polydopamine, and preparing the mixed membrane with the surface being a hydrophilic layer and the middle being a hydrophobic layer;
the rotating speed of mechanical stirring is 60 r/min-200 r/min;
suspending and washing the mixed membrane prepared in the step 12 with deionized water for 3-5 times to obtain a wet-hydrophilic and hydrophobic mixed membrane;
step 14, nitrogen drying;
placing the wet-hydrophilic and hydrophobic mixed membrane into a nitrogen drying oven at 50-75 ℃ for drying treatment for 16-18 h, and taking out to obtain a hydrophilic and hydrophobic mixed membrane (2);
step two, preparing a backflow prevention film;
and (3) stripping the hydrophilic and hydrophobic mixed film (2) prepared in the step one by using tweezers, and removing the modified hydrophilic layer positioned on the surface layer to obtain the PET-based Janus film performance backflow preventing film (3) with one surface being a hydrophobic transition layer and the other surface being the modified hydrophilic layer.
Drawings
FIG. 1 is a flow chart of the invention for preparing a PET-based Janus film performance backflow prevention film.
FIG. 2 is an electron microscopy scan of a backflow prevention film of PET-based Janus film properties in accordance with the present invention.
Fig. 3 is a schematic drawing of contact angle of a backflow preventing film of PET-based Janus film performance in the present invention.
FIG. 4 is a graph of the unidirectional liquid permeation performance of a PET-based Janus film performance backflow prevention film of the present invention.
FIG. 5 is a block diagram of a filter of PET-based Janus membrane performance in accordance with the present invention.
Fig. 5A is a cross-sectional view of a filter of PET-based Janus membrane performance in accordance with the present invention.
Fig. 5B is an exploded view of a filter of PET-based Janus membrane performance in accordance with the present invention.
Fig. 5C is another exploded view of a filter of PET-based Janus membrane performance in accordance with the present invention.
FIG. 6 is a graph of the use of a PET-based Janus membrane-enabled filter of the present invention to access a tubing for backflow prevention.
FIG. 7 is a graph of permeation flux data for a backflow prevention membrane of PET-based Janus membrane performance in accordance with the present invention.
FIG. 8 is a graph of backflow pressure data for backflow prevention films of PET-based Janus film performance in accordance with the present invention.
Detailed Description
The present invention will be described in further detail with reference to the accompanying drawings.
Preparation of anti-reflux film with PET-based Janus film performance
Referring to FIG. 1, a PET-based Janus membrane filter of the present invention was prepared by the steps of:
step one, a modification process from a hydrophobic membrane to a hydrophilic membrane;
and (3) completely dissolving the weighed dopamine in Tris-HCl buffer solution by using magnetic stirring to prepare a dopamine hydrochloride mixed solution.
The dopamine hydrochloride mixed solution is formed by adding 0.15 g-0.25 g of dopamine into 100mL of Tris-HCl buffer solution.
The concentration of Tris-HCl buffer was 1mol/L, pH=8.5.
placing the multi-layer PTFE/PET composite hydrophobic filter membrane 1 into the dopamine hydrochloride mixed solution prepared in the step 11;
mechanically stirring for 16-18 h at 20-40 ℃ to enable dopamine to undergo self-polymerization on the membrane surface to form polydopamine, and preparing the mixed membrane with the surface being a hydrophilic layer and the middle being a hydrophobic layer.
The rotating speed of mechanical stirring is 60 r/min-200 r/min.
In the invention, the PTFE/PET composite hydrophobic filter membrane is a microporous multilayer filter membrane with a support, and the general pore diameter is 200 nm-250 nm. One surface of the PTFE/PET composite hydrophobic filter membrane is smoother and the other surface is slightly rough, the smooth surface is made of PTFE (polytetrafluoroethylene) material, the rough surface plays a supporting role, and the supporting material is PET (polyethylene terephthalate).
For characterization of the multilayer structure of the original PTFE/PET composite hydrophobic filter, see fig. 1, the multilayer structure of the PTFE/PET composite hydrophobic filter 1 is shown schematically as: consists of an A hydrophobic surface layer 1A, A hydrophobic transition layer 11, a B hydrophobic transition layer 12, a C hydrophobic transition layer 13 and a B hydrophobic surface layer 1B. Wherein A represents PTFE and B represents PET.
The raw material PET used in the invention is nontoxic, odorless, sanitary and safe, and is widely used in medical equipment.
and (3) suspending and washing the mixed film prepared in the step (12) with deionized water for 3-5 times to obtain the wet-hydrophilic and hydrophobic mixed film.
Step 14, nitrogen drying;
and (3) placing the wet-hydrophilic and hydrophobic mixed membrane into a nitrogen drying oven at 50-75 ℃ for drying treatment for 16-18 h, and taking out to obtain the hydrophilic and hydrophobic mixed membrane 2.
As shown in fig. 1, the hydrophilic-hydrophobic hybrid membrane 2 has a multilayer structure of: consists of a hydrophilic surface layer A2A, A, a hydrophobic transition layer 11, a hydrophobic transition layer B12, a hydrophobic transition layer C13 and a hydrophilic surface layer B2B.
In the present invention, it was found by scanning electron microscopy of the hydrophilic-hydrophobic hybrid membrane 2 that the amount of polydopamine on the surface layers (i.e. the a hydrophilic surface layer 2A and the B hydrophilic surface layer 2B) was greater than that of the unit layer as shown in fig. 2. The hydrophilic property of the polydopamine changes the original hydrophobic property of the surface membrane of the PTFE/PET composite hydrophobic filter membrane into the hydrophilic property, but the membrane positioned at the middle part still maintains the hydrophobic property.
Specifically, in fig. 2, the amount of polydopamine on the C hydrophobic transition layer 13 of the middle layer is significantly lower than the amount of polydopamine on the B hydrophobic surface layer 1B because of the barrier of the B hydrophobic surface layer 1B, which is also the mechanism by which the B hydrophobic surface layer 1B is modified to the B hydrophilic surface layer 2B. While B has little polydopamine content on the hydrophobic transition layer 12. This means that the amount of polydopamine is smaller nearer the middle.
Step two, preparing a backflow prevention film;
and (3) peeling the hydrophilic and hydrophobic mixed film prepared in the step (I) by using tweezers, and removing the modified hydrophilic layer positioned on the surface layer to obtain the anti-backflow film 3 with the PET-based Janus film performance, wherein one surface of the anti-backflow film is a hydrophobic transition layer, and the other surface of the anti-backflow film is the modified hydrophilic layer.
Referring to fig. 1, the multi-layer structure of the backflow preventing film 3 is: consists of a hydrophobic transition layer (12) B, a hydrophobic transition layer (13) C and a hydrophilic surface layer (2B) B.
In the invention, the PET side combined with the PTFE layer still keeps hydrophobic because of the protection of the PTFE layer, and the PET bare side is hydrophilic because of the existence of polydopamine, so the backflow prevention film 3 is a PET-based Janus film system with different two sides wettability, as shown in figure 3. The wettability of both sides of the prepared PET-based Janus film was tested using a contact angle tester. The hydrophobic transition layer 12 is super-hydrophobic, the contact angle to water is 139 degrees, the hydrophilic surface layer 2B shows super-hydrophilicity, and the contact angle to water is 0 degrees.
Referring to fig. 4, the backflow preventing film 3 was placed between two glass blocks, and the liquid permeation and backflow preventing process of the backflow preventing film 3 of the PET-based Janus film performance was recorded using a camera (nikon camera taking a photograph at a resolution pixel of 1280X 720). When the B hydrophobic transition layer 12 (hydrophobic side of the Janus membrane) is facing upwards, the droplet may spontaneously permeate through the backflow preventing membrane 3 under the force of gravity (as shown in fig. 4 (a)). When the B hydrophilic surface layer 2B (hydrophilic side of Janus film) is facing upward, the droplets landing on the surface spread rapidly and cannot pass through the backflow preventing film 3 (as shown in fig. 4 (B)).
(II) Filter Assembly of PET-based Janus Membrane Performance
Referring to fig. 5, 5A, 5B, 5C, a filter 6 of PET-based Janus membrane performance is composed of an upper joint 4, a backflow preventing membrane 3, and a lower joint 5. The backflow preventing film 3 is disposed between the upper joint 4 and the lower joint 5.
Referring to fig. 5B and 5C, the upper joint 4 is provided with an upper hollow conduit 4A and an upper countersunk cavity 4B.
Referring to fig. 5B and 5C, the lower joint 5 is provided with a lower hollow conduit 5A and a countersunk cavity 5B.
The hydrophobic transition layer 12 of the anti-reflux film 3 faces the inner wall of the upper countersunk cavity 4B of the upper joint 4, and the hydrophilic surface layer 2B of the anti-reflux film 3 faces the inner wall of the lower countersunk cavity 5B of the lower joint 5.
Because the conventional infusion tube is a round and slender flexible plastic tube, the specific shape of the filter 6 with the PET-based Janus membrane performance is designed according to the conventional infusion tube, the original structure of the conventional infusion tube is not changed, and the structure of the filter 6 with the PET-based Janus membrane performance is designed to be matched with the conventional infusion tube, so that the adaptability of the filter 6 with the PET-based Janus membrane performance is improved.
(III) infusion tube with PET-based Janus membrane performance
Referring to FIG. 6, the filter 6 of the PET-based Janus film of the present invention is attached to a conventional infusion tube, which forms a PET-based Janus film near the infusion end. The connection relation is as follows: the upper hollow conduit 4A of the upper joint 4 is connected with the infusion tube feeding pipeline 6A, and the lower hollow conduit 5A of the lower joint 5 is connected with the infusion tube discharging pipeline 6B.
In the filter 6 of the PET-based Janus film, the B hydrophobic transition layer 12 of the backflow prevention film 3 is faced to the feed inlet, and the B hydrophilic surface layer 2B is faced to the discharge outlet. The dyed physiological saline is injected through the feed inlet, and the liquid can spontaneously go from the hydrophobic side to the hydrophilic side by utilizing the unidirectional permeability of the Janus membrane, so that the normal transfusion process is not affected, as shown in fig. 6 (a). After the dyed normal saline completely passes through the filter 6 of the PET-based Janus membrane, the height of the discharge port side is raised, so that the pressure of the human vein and the pressure of liquid in the infusion tube are simulated, and the dyed normal saline is found to be unable to reversely flow back through the B hydrophilic surface layer 2B, as shown in fig. 6 (B), so that the problem of blood backflow caused by untimely treatment when the infusion is finished and the pressure of human blood is larger than the pressure of the infusion liquid is hopefully solved.
The performance parameters of filter 6 were further tested for PET-based Janus membrane performance. As shown in FIG. 7, by measuring the volume of the liquid passing through the filter 6 of the PET-based Janus membrane per unit time, the permeation flux parameter of the filter 6, which obtains the performance of the PET-based Janus membrane, can be calculated as 4 L.m by dividing the volume of the passing liquid by the area of the backflow preventing membrane 3 in the filter 6 -2 ·h -1 . Figure 8 shows the backflow prevention pressure of the filter 6 of PET-based Janus membrane performance, the backflow prevention pressure value being 490Pa obtained by measuring the height of the water column.
The first aspect of the invention provides a method for preparing the backflow prevention film, the second aspect is to assemble the backflow prevention film into a filter, and the third aspect is to connect the filter to a traditional infusion tube to form a novel infusion tube. The invention aims to solve the technical problem of how to improve the prevention of blood backflow caused by failure to timely treat the transfusion, thereby reducing the occurrence of medical accidents.
Claims (1)
1. A method for manufacturing a transfusion tube for preventing blood backflow by using a PET-based Janus membrane with the anti-backflow membrane performance, wherein the manufactured transfusion tube comprises a circular and slender flexible plastic tube transfusion tube and a filter (6) with the PET-based Janus membrane performance;
the preparation of the anti-reflux film with the PET-based Janus film performance comprises the following steps:
step one, a modification process from a hydrophobic membrane to a hydrophilic membrane;
step 11, preparing a dopamine hydrochloride mixed solution;
completely dissolving the weighed dopamine in Tris-HCl buffer solution by utilizing magnetic stirring to prepare a dopamine hydrochloride mixed solution;
the dopamine hydrochloride mixed solution is formed by adding 0.15 g-0.25 g of dopamine into 100mL of Tris-HCl buffer solution;
the concentration of Tris-HCl buffer is 1mol/L, and the pH value is 8.5;
step 12, self-polymerization under mechanical stirring to form polydopamine;
placing the multi-layer PTFE/PET composite hydrophobic filter membrane (1) into the dopamine hydrochloride mixed solution prepared in the step 11;
mechanically stirring for 16-18 h at 20-40 ℃ to enable dopamine to undergo self-polymerization on the membrane surface to form polydopamine, and preparing the mixed membrane with the surface being a hydrophilic layer and the middle being a hydrophobic layer;
the rotating speed of mechanical stirring is 60 r/min-200 r/min;
step 13, washing;
suspending and washing the mixed membrane prepared in the step 12 with deionized water for 3-5 times to obtain a wet-hydrophilic and hydrophobic mixed membrane;
step 14, nitrogen drying;
placing the wet-hydrophilic and hydrophobic mixed membrane into a nitrogen drying oven at 50-75 ℃ for drying treatment for 16-18 h, and taking out to obtain a hydrophilic and hydrophobic mixed membrane (2);
step two, preparing a backflow prevention film;
stripping the hydrophilic and hydrophobic mixed film (2) prepared in the first step by using tweezers, and removing the modified hydrophilic layer positioned on the surface layer to obtain the PET-based Janus film performance backflow preventing film (3) with one surface being a hydrophobic transition layer and the other surface being the modified hydrophilic layer;
the multilayer structure of the anti-reflux film (3) with PET-based Janus film performance is as follows: consists of a hydrophobic transition layer (12) B, a hydrophobic transition layer (13) C and a hydrophilic surface layer (2B); the hydrophobic transition layer (12), the hydrophobic transition layer (13) and the hydrophilic surface layer (2B) are sequentially arranged from top to bottom;
the hydrophobic transition layer (12) is super-hydrophobic, the contact angle of the hydrophobic transition layer to water is 139 degrees, the hydrophilic surface layer (2B) is super-hydrophilic, and the contact angle of the hydrophobic transition layer to water is 0 degree;
the anti-backflow film with the PET-based Janus film performance is used for manufacturing a filter (6) with the PET-based Janus film performance;
the filter (6) with the PET-based Janus membrane performance consists of an upper joint (4), a backflow prevention membrane (3) and a lower joint (5); the backflow prevention film (3) is arranged between the upper joint (4) and the lower joint (5);
an upper hollow guide pipe (4A) and an upper countersunk cavity (4B) are arranged on the upper joint (4);
a lower hollow conduit (5A) and a countersunk head cavity (5B) are arranged on the lower joint (5);
the B hydrophobic transition layer (12) of the backflow prevention film (3) faces the inner wall of the upper countersunk head cavity (4B) of the upper joint (4), and the B hydrophilic surface layer (2B) of the backflow prevention film (3) faces the inner wall of the lower countersunk head cavity (5B) of the lower joint (5);
the permeation flux parameter of the filter (6) with PET-based Janus membrane performance is 4L.m -2 ·h -1 The value of the backflow prevention pressure is 490Pa;
the PET-based Janus membrane filter (6) is formed by connecting a round slender flexible plastic tube infusion tube;
the connection mode with the round slender flexible plastic tube infusion tube is as follows: an upper hollow conduit (4A) of the upper joint (4) is connected with a transfusion tube feeding pipeline (6A), and a lower hollow conduit (5A) of the lower joint (5) is connected with a transfusion tube discharging pipeline (6B).
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202210526487.1A CN115068732B (en) | 2022-05-16 | 2022-05-16 | Infusion tube with PET-based Janus membrane for preventing blood backflow |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202210526487.1A CN115068732B (en) | 2022-05-16 | 2022-05-16 | Infusion tube with PET-based Janus membrane for preventing blood backflow |
Publications (2)
Publication Number | Publication Date |
---|---|
CN115068732A CN115068732A (en) | 2022-09-20 |
CN115068732B true CN115068732B (en) | 2023-05-02 |
Family
ID=83247754
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202210526487.1A Active CN115068732B (en) | 2022-05-16 | 2022-05-16 | Infusion tube with PET-based Janus membrane for preventing blood backflow |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN115068732B (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN116459381B (en) * | 2023-04-04 | 2024-03-29 | 山东大学 | PH-sensitive type chronic wound medical dressing with unidirectional liquid guiding function and preparation method thereof |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101507849A (en) * | 2009-03-19 | 2009-08-19 | 贾宇东 | Sensitive blood-return detection and sensitive switch one-way reverse-blocking device |
US9717887B2 (en) * | 2013-12-04 | 2017-08-01 | B. Braun Melsungen Ag | Catheter assembly blood control device and related methods |
CN109276998B (en) * | 2018-08-28 | 2021-11-05 | 中国科学院宁波材料技术与工程研究所 | High-performance Janus forward osmosis membrane and preparation method thereof |
CN214074508U (en) * | 2020-09-21 | 2021-08-31 | 刘素云 | Liquid-stopping and blood-returning-preventing precise-filtering infusion apparatus |
-
2022
- 2022-05-16 CN CN202210526487.1A patent/CN115068732B/en active Active
Also Published As
Publication number | Publication date |
---|---|
CN115068732A (en) | 2022-09-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN115068732B (en) | Infusion tube with PET-based Janus membrane for preventing blood backflow | |
CA2974971C (en) | Iv set having an air stop membrane | |
CA2567856A1 (en) | Use of a dialysis membrane for reducing blood free light chain concentration | |
CA2974966C (en) | Air stop membrane for maintaining a fluid column in an iv set | |
US20100204565A1 (en) | Microdialysis Catheter and a Method of Making a Microdialysis Catheter | |
CN101668555A (en) | Pressure sensing device and use of the same in a connecting structure | |
CN1190902A (en) | System and treating extracorporeally circulating blood for curing inflamatory diseases | |
JP2023139190A (en) | bubble trap device | |
US8894749B2 (en) | Bubble reducer for eliminating gas bubbles from a flow | |
KR101342439B1 (en) | Device for trapping air bubble of the fluid warming and rapid infusion system | |
CN102078646A (en) | Polyether sulfone hollow fiber blood dialyzer | |
Potger et al. | Air transmission comparison of the affinity fusion oxygenator with an integrated arterial filter to the affinity NT oxygenator with a separate arterial filter | |
WO2016150319A2 (en) | Device preventing backflow of blood, and medical infusion device | |
CN106860949B (en) | Automatic liquid-stopping infusion apparatus | |
Guan et al. | Evaluation of Quadrox-i® adult hollow fiber oxygenator with integrated arterial filter | |
CN103041468B (en) | A kind of infusion unit titrimeter of blood return prevention and blood return preventing infusion device | |
CN204543085U (en) | Blood return preventer and medical Transfusion device | |
CN201969096U (en) | PES hollow cored fibre hemodialyzer | |
CN206473618U (en) | A kind of sensitive blood back flowing device | |
CN209378177U (en) | A kind of secondary filter type automatic liquid-stopping transfusion apparatus | |
CN211301514U (en) | Device for preventing blood return of infusion loop | |
CN210542457U (en) | Dripping-clean type multi-hole built-in-bag infusion apparatus | |
CN213312291U (en) | Closed blood return machine | |
CN216703092U (en) | Blood return prevention medical infusion apparatus | |
CN210992208U (en) | Automatic stop type blood return prevention precise filtering infusion apparatus |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant |