CN115040588A - Traditional Chinese medicine for relieving twelve meridian arthralgia, preparation method and application thereof - Google Patents
Traditional Chinese medicine for relieving twelve meridian arthralgia, preparation method and application thereof Download PDFInfo
- Publication number
- CN115040588A CN115040588A CN202210826278.9A CN202210826278A CN115040588A CN 115040588 A CN115040588 A CN 115040588A CN 202210826278 A CN202210826278 A CN 202210826278A CN 115040588 A CN115040588 A CN 115040588A
- Authority
- CN
- China
- Prior art keywords
- parts
- arthralgia
- meridian
- chinese medicine
- traditional chinese
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 41
- 208000006820 Arthralgia Diseases 0.000 title claims abstract description 33
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- 239000002994 raw material Substances 0.000 claims abstract description 32
- 238000000034 method Methods 0.000 claims abstract description 22
- 244000197580 Poria cocos Species 0.000 claims abstract description 12
- 235000008599 Poria cocos Nutrition 0.000 claims abstract description 12
- 241000205585 Aquilegia canadensis Species 0.000 claims abstract description 11
- 241000758794 Asarum Species 0.000 claims abstract description 11
- 244000306301 Caesalpinia sappan Species 0.000 claims abstract description 11
- 235000015162 Caesalpinia sappan Nutrition 0.000 claims abstract description 11
- 244000037364 Cinnamomum aromaticum Species 0.000 claims abstract description 11
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 claims abstract description 11
- 235000014066 European mistletoe Nutrition 0.000 claims abstract description 11
- 244000303040 Glycyrrhiza glabra Species 0.000 claims abstract description 11
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims abstract description 11
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims abstract description 11
- 235000003140 Panax quinquefolius Nutrition 0.000 claims abstract description 11
- 241000405414 Rehmannia Species 0.000 claims abstract description 11
- 244000152640 Rhipsalis cassutha Species 0.000 claims abstract description 11
- 235000012300 Rhipsalis cassutha Nutrition 0.000 claims abstract description 11
- 235000008434 ginseng Nutrition 0.000 claims abstract description 11
- 241000112528 Ligusticum striatum Species 0.000 claims abstract description 10
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims abstract description 10
- 244000237330 gutta percha tree Species 0.000 claims abstract description 10
- 235000011477 liquorice Nutrition 0.000 claims abstract description 10
- 241000501743 Gentiana macrophylla Species 0.000 claims abstract description 8
- 241000382455 Angelica sinensis Species 0.000 claims abstract description 7
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims abstract description 5
- 229940040145 liniment Drugs 0.000 claims description 28
- 239000000865 liniment Substances 0.000 claims description 28
- 239000000843 powder Substances 0.000 claims description 28
- 230000007812 deficiency Effects 0.000 claims description 16
- 208000011580 syndromic disease Diseases 0.000 claims description 14
- 239000002245 particle Substances 0.000 claims description 10
- 210000003414 extremity Anatomy 0.000 claims description 7
- 238000002791 soaking Methods 0.000 claims description 7
- 210000003127 knee Anatomy 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 6
- 240000000031 Achyranthes bidentata Species 0.000 claims description 5
- 238000001914 filtration Methods 0.000 claims description 5
- 244000061520 Angelica archangelica Species 0.000 claims description 4
- 235000001287 Guettarda speciosa Nutrition 0.000 claims description 4
- 238000002386 leaching Methods 0.000 claims description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 2
- 208000009205 Tinnitus Diseases 0.000 claims description 2
- 208000012886 Vertigo Diseases 0.000 claims description 2
- 231100000886 tinnitus Toxicity 0.000 claims description 2
- 231100000889 vertigo Toxicity 0.000 claims description 2
- 241000208340 Araliaceae Species 0.000 claims 2
- 238000010298 pulverizing process Methods 0.000 claims 2
- 239000011812 mixed powder Substances 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 208000002193 Pain Diseases 0.000 abstract description 46
- 210000004185 liver Anatomy 0.000 abstract description 45
- 230000036407 pain Effects 0.000 abstract description 45
- 210000003734 kidney Anatomy 0.000 abstract description 36
- 238000011282 treatment Methods 0.000 abstract description 31
- 230000000694 effects Effects 0.000 abstract description 25
- 239000008280 blood Substances 0.000 abstract description 23
- 210000004369 blood Anatomy 0.000 abstract description 23
- 230000008901 benefit Effects 0.000 abstract description 10
- 230000008569 process Effects 0.000 abstract description 7
- 231100000331 toxic Toxicity 0.000 abstract description 6
- 230000002588 toxic effect Effects 0.000 abstract description 6
- 210000001835 viscera Anatomy 0.000 abstract description 6
- 230000007774 longterm Effects 0.000 abstract description 3
- 238000012377 drug delivery Methods 0.000 abstract description 2
- 238000010579 first pass effect Methods 0.000 abstract description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract description 2
- 229940126701 oral medication Drugs 0.000 abstract description 2
- 230000004044 response Effects 0.000 abstract description 2
- 244000131316 Panax pseudoginseng Species 0.000 abstract 1
- 210000002435 tendon Anatomy 0.000 description 53
- 210000003205 muscle Anatomy 0.000 description 32
- 210000002683 foot Anatomy 0.000 description 24
- 210000000988 bone and bone Anatomy 0.000 description 16
- 210000001503 joint Anatomy 0.000 description 16
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 15
- 201000010099 disease Diseases 0.000 description 14
- 210000000952 spleen Anatomy 0.000 description 13
- 210000002216 heart Anatomy 0.000 description 11
- 235000009508 confectionery Nutrition 0.000 description 10
- 239000000796 flavoring agent Substances 0.000 description 9
- 235000019634 flavors Nutrition 0.000 description 9
- 240000004371 Panax ginseng Species 0.000 description 8
- 229940079593 drug Drugs 0.000 description 8
- 238000000227 grinding Methods 0.000 description 8
- 210000004072 lung Anatomy 0.000 description 8
- 230000001737 promoting effect Effects 0.000 description 7
- 230000017531 blood circulation Effects 0.000 description 6
- 230000001717 pathogenic effect Effects 0.000 description 6
- 210000002784 stomach Anatomy 0.000 description 6
- 235000006484 Paeonia officinalis Nutrition 0.000 description 5
- 241001106477 Paeoniaceae Species 0.000 description 5
- 241001180876 Saposhnikovia Species 0.000 description 5
- 210000000232 gallbladder Anatomy 0.000 description 5
- 210000002808 connective tissue Anatomy 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 230000007935 neutral effect Effects 0.000 description 4
- 230000008961 swelling Effects 0.000 description 4
- 206010062717 Increased upper airway secretion Diseases 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 3
- 206010034464 Periarthritis Diseases 0.000 description 3
- 210000001015 abdomen Anatomy 0.000 description 3
- 238000005452 bending Methods 0.000 description 3
- 230000004087 circulation Effects 0.000 description 3
- 210000003195 fascia Anatomy 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- 208000014674 injury Diseases 0.000 description 3
- 230000005906 menstruation Effects 0.000 description 3
- 210000000056 organ Anatomy 0.000 description 3
- 208000026435 phlegm Diseases 0.000 description 3
- 238000005728 strengthening Methods 0.000 description 3
- 230000035900 sweating Effects 0.000 description 3
- 230000008736 traumatic injury Effects 0.000 description 3
- 210000000689 upper leg Anatomy 0.000 description 3
- 241000427159 Achyranthes Species 0.000 description 2
- 241001254604 Angelica pubescens Species 0.000 description 2
- 208000010428 Muscle Weakness Diseases 0.000 description 2
- 206010028372 Muscular weakness Diseases 0.000 description 2
- 208000004880 Polyuria Diseases 0.000 description 2
- 208000025747 Rheumatic disease Diseases 0.000 description 2
- 206010040925 Skin striae Diseases 0.000 description 2
- 208000005392 Spasm Diseases 0.000 description 2
- 230000003213 activating effect Effects 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 210000002318 cardia Anatomy 0.000 description 2
- 230000035619 diuresis Effects 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 238000005469 granulation Methods 0.000 description 2
- 230000003179 granulation Effects 0.000 description 2
- 210000003128 head Anatomy 0.000 description 2
- 230000009545 invasion Effects 0.000 description 2
- 210000002429 large intestine Anatomy 0.000 description 2
- 210000002414 leg Anatomy 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 231100000862 numbness Toxicity 0.000 description 2
- 210000003516 pericardium Anatomy 0.000 description 2
- 239000011505 plaster Substances 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 235000021251 pulses Nutrition 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 230000000552 rheumatic effect Effects 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 235000019640 taste Nutrition 0.000 description 2
- 210000003371 toe Anatomy 0.000 description 2
- 210000003932 urinary bladder Anatomy 0.000 description 2
- 239000000341 volatile oil Substances 0.000 description 2
- 238000010792 warming Methods 0.000 description 2
- 206010003694 Atrophy Diseases 0.000 description 1
- 206010063659 Aversion Diseases 0.000 description 1
- 208000020084 Bone disease Diseases 0.000 description 1
- 206010006002 Bone pain Diseases 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 206010013935 Dysmenorrhoea Diseases 0.000 description 1
- 241000208688 Eucommia Species 0.000 description 1
- 241001071795 Gentiana Species 0.000 description 1
- 235000017443 Hedysarum boreale Nutrition 0.000 description 1
- 235000007858 Hedysarum occidentale Nutrition 0.000 description 1
- 206010061245 Internal injury Diseases 0.000 description 1
- 208000007101 Muscle Cramp Diseases 0.000 description 1
- 208000029578 Muscle disease Diseases 0.000 description 1
- 206010050031 Muscle strain Diseases 0.000 description 1
- 208000000112 Myalgia Diseases 0.000 description 1
- 244000236658 Paeonia lactiflora Species 0.000 description 1
- 235000008598 Paeonia lactiflora Nutrition 0.000 description 1
- 235000001188 Peltandra virginica Nutrition 0.000 description 1
- 240000007643 Phytolacca americana Species 0.000 description 1
- 240000004922 Vigna radiata Species 0.000 description 1
- 235000010721 Vigna radiata var radiata Nutrition 0.000 description 1
- 235000011469 Vigna radiata var sublobata Nutrition 0.000 description 1
- 208000031971 Yin Deficiency Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000037444 atrophy Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 239000002639 bone cement Substances 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 210000005069 ears Anatomy 0.000 description 1
- 238000005485 electric heating Methods 0.000 description 1
- 230000008451 emotion Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 230000004438 eyesight Effects 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000001947 glycyrrhiza glabra rhizome/root Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 210000000629 knee joint Anatomy 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 210000003041 ligament Anatomy 0.000 description 1
- 238000011866 long-term treatment Methods 0.000 description 1
- 230000001050 lubricating effect Effects 0.000 description 1
- 238000005461 lubrication Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000036651 mood Effects 0.000 description 1
- 230000004118 muscle contraction Effects 0.000 description 1
- 208000015001 muscle soreness Diseases 0.000 description 1
- 230000003387 muscular Effects 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000009323 psychological health Effects 0.000 description 1
- 235000019633 pungent taste Nutrition 0.000 description 1
- 210000001187 pylorus Anatomy 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 210000001991 scapula Anatomy 0.000 description 1
- 238000007790 scraping Methods 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000010025 steaming Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 235000019605 sweet taste sensations Nutrition 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/238—Saposhnikovia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
- A61K36/268—Asarum (wild ginger)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/46—Eucommiaceae (Eucommia family), e.g. hardy rubber tree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/51—Gentianaceae (Gentian family)
- A61K36/515—Gentiana
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Otolaryngology (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Nutrition Science (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a traditional Chinese medicine for relieving twelve meridian arthralgia, a preparation method and an application thereof, wherein the traditional Chinese medicine for relieving twelve meridian arthralgia comprises the following raw material components: radix angelicae pubescentis, mistletoe, eucommia ulmoides, radix achyranthis bidentatae, asarum, gentiana macrophylla, poria cocos, cassia bark, radix sileris, ginseng, liquorice, angelica sinensis, sappan wood, radix paeoniae alba, dried rehmannia, honeysuckle and ligusticum wallichii. The traditional Chinese medicine provided by the invention has the advantages that various raw materials are mutually compatible and take effect synergistically, the traditional Chinese medicine can achieve better effects of tonifying liver and kidney, tonifying qi and blood, dispelling wind-damp and relieving arthralgia, and has strong pertinence to the dredging of liver and kidney meridians in twelve meridians, remarkable curative effect and quick response. The invention adopts the outer skin permeation drug delivery, is safe without toxic and side effects, does not enter the mouth, does not pass through the digestive tract, avoids the first pass effect of the liver, protects the viscera of the liver, the kidney and the like due to the long-term taking of the oral drug, has the characteristics of convenient use and carrying, no pain in the treatment process, wide application population and suitability for clinical popularization and application.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine for relieving twelve meridian muscle arthralgia, and a preparation method and application thereof.
Background
The term "Jingjin" is first known in the book Ling Shu Jing, Ming Zhang Guest indicates: what is also what is the case of the twelve main meridians with their meridians and tendons going back and forth? The meridians cover the exterior and enter and exit the zang-fu organs, and they are passed along with the tendons and bones, so they can maintain the meridians and their body. Although the muscles and tendons are sufficient, the most important is the region between four limbs and the valley, so that the muscles and tendons are located at the joints. The meridians and collaterals are the generalization of the physiological and pathological laws of human ligamentology, musculology and the affiliated tissues thereof by ancient people applying the current anatomical knowledge and taking twelve running force lines as the rules.
The twelve main meridians are the essential parts of the twelve main meridians that nourish the muscles, muscles and joints. The twelve main meridians include the three yin meridians of hand (lung meridian of hand taiyin, pericardium meridian of hand jueyin, heart meridian of hand shaoyin), three yang meridians of hand (large intestine meridian of hand yangming, triple energizer meridian of hand shaoyang, small intestine meridian of hand taiyang), three yin meridians of foot (spleen meridian of foot taiyin, liver meridian of foot jueyin, kidney meridian of foot shaoyin), and three yang meridians of foot (stomach meridian of foot yangming, gallbladder meridian of foot shaoyang, bladder meridian of foot taiyang). They all start at the ends of the four limbs, gather in the joints and bones and move towards the head and face of the trunk. The twelve meridians are located on the body surface and do not enter the viscera, and they are divided into rigid tendons and soft tendons. The tendons of the rigid (yang) are distributed on the back of the neck and the outer sides of the four limbs, and mainly meridian tendons of the yang meridians of the hand and the foot; the tendons of the liver and kidney are distributed in the chest, abdomen and the inner sides of the four limbs, and mainly the tendons of the yin meridians of the hand and foot. The three yang meridians of foot originate in the toes and run upward along the outside of the thigh to form a smooth surface; the three yin meridians of the foot originate in the toes and run along the thigh to join the yin apparatus (abdomen); the three yang meridians of the hand originate in the fingers, travel along the lateral side of the arm and ascend to the corners (head); the three yin meridians of the hand originate in the fingers and travel along the medial side of the arm to ascend to the cardia (chest).
The meridians and collaterals run and the tendons run. The meridians and collaterals are three-dimensionally distributed and go with each other, and it is important to supplement the areas which the twelve main meridians do not reach. The points of origin of the meridians and collaterals are different from those of the meridians and collaterals. Meridians can be summarized by points and lines. The starting and stopping points of the warp ribs are mostly in the shapes of strips, bundles and sheets. For example, the spleen meridian tendon of foot taiyin is attached to the spine to form a strip. The heart meridian of hand jueyin is weakened and scattered in the chest, knotted in the cardia and stopped at the diaphragm, and thus it is in the form of tablet. The three-dimensional shape of the sheet and the surface presented by the meridians and muscles can more widely maintain the whole body, mainly restrain the bones and benefit the joints; the two meridians are nourished by the qi and blood of the twelve main meridians, which in turn distributes the qi and blood of the twelve main meridians to the whole body to nourish the whole body. The twelve main meridians are tied with the skeleton and are widely distributed in the eyes, ears, mouth, nose, tongue, and yin organs, and play a role in maintaining the functions of these organs. The meridians and tendons fix the bones outside and the viscera inside, and together with the meridians, they form an organic whole.
The arthralgia syndrome in traditional Chinese medicine is formed by invasion of pathogenic wind, cold and dampness and combination of the pathogenic wind, cold, dampness, pathogenic factors and the shape of skin, flesh, muscles, blood vessels, viscera and viscera. Different syndromes are formed. Arthralgia caused by deficiency of both liver and kidney is a disease characterized by repeated attacks of pain on joints, muscles, limbs and other parts. Has the following characteristics in clinic: the liver and kidney meridians, i.e., the liver meridian of foot jueyin and the kidney meridian of foot shaoyin, have connective tissues adhered to any part of the two meridians, which leads to qi stagnation, blood stasis, muscle soreness and even severe spontaneous pain. The pain caused by wind-cold is characterized by being mild when encountering warm; pain caused by stagnated heat is characterized by swelling, burning pain; muscle weakness due to qi deficiency; atrophy of muscle and tendon caused by blood deficiency; these problems are also recurring due to environmental climate, mood, strain, etc. If the adhesion and the tendon sections cannot be dredged in time, the circulation of other meridians and tendons can be affected, and the physical and psychological health of the patient is greatly damaged.
Currently, there are three main products for the treatment of the above diseases: (1) muscle and bone paste, gel, spray (external application) and so on are mostly used for treating local muscle and bone diseases in the musculature. The external product solves various pains caused by the adhesion of muscles, bones and ligaments. (2) Infrared lamps: hot compress and electric heating. The local temperature of the pain of the human body is increased, the swelling and inflammation around the joints are changed, and the aim of relieving the diseases is fulfilled. (3) The medicated liquor is prepared by mixing various rare Chinese medicinal materials with liquor to permeate out effective components. The patient needs to drink for a long time, and the recovery period is very long.
In the prior art, no traditional Chinese medicine for treating the diseases by specifically dredging the liver and kidney meridians is found.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine for tonifying liver and kidney, tonifying qi and blood, dispelling wind-damp and relieving arthralgia, which can effectively dredge and regulate qi and blood circulation to disperse weakness and block, is combined with a tendon-poking treatment method, can quickly reach a focus, quickly decompose connective tissues of tendons and joints, effectively relieve the clamping pressure of transverse collaterals on the tendon-poking circulation of liver and kidney on meridians and joints, and further effectively treat the arthralgia caused by deficiency of both liver and kidney.
In order to achieve the purpose, the invention adopts the following technical scheme:
the invention provides a traditional Chinese medicine for relieving twelve meridian arthralgia, which comprises the following raw material components: radix angelicae pubescentis, mistletoe, eucommia ulmoides, radix achyranthis bidentatae, asarum, gentiana macrophylla, poria cocos, cassia bark, radix sileris, ginseng, liquorice, angelica sinensis, sappan wood, radix paeoniae alba, dried rehmannia, honeysuckle and ligusticum wallichii. Preferably, the feed comprises the following raw material components in parts by weight: 40-60 parts of radix angelicae pubescentis, 10-20 parts of mistletoe, 25-35 parts of eucommia ulmoides, 20-30 parts of radix achyranthis bidentatae, 20-45 parts of asarum, 20-35 parts of radix gentianae macrophyllae, 30-45 parts of poria cocos, 25-30 parts of cassia bark, 20-30 parts of radix sileris, 20-35 parts of ginseng, 20-30 parts of liquorice, 20-35 parts of angelica tail, 20-25 parts of sappan wood, 20-30 parts of radix paeoniae alba, 20-25 parts of dried rehmannia, 15-20 parts of honeysuckle and 20-35 parts of ligusticum wallichii.
The invention has the following advantages:
radix angelicae pubescentis: pungent and bitter with warm nature. It enters liver, kidney and bladder meridians. Dispel wind-damp, alleviate pain, release exterior. Is a traditional Chinese medicine which is good at treating pathogenic wind and can dispel wind-cold-dampness in bladder meridian tendons of foot taiyang, kidney meridian tendons of foot shaoyin and gaps between muscles and bones.
Mistletoe: bitter taste and mild nature. It enters liver and kidney meridians. Dispel wind-damp, tonify liver and kidney, strengthen tendons and bones, and has the functions of dispelling diseases, removing dampness, expelling pus, promoting granulation, promoting blood circulation and relieving pain.
Eucommia ulmoides: sweet and slightly pungent in flavor and warm in nature. Enter liver and kidney meridians. Tonifying liver and kidney, strengthening tendons and bones, and relieving soreness of waist and back caused by deficiency of liver and kidney.
Achyranthes root: bitter, sweet and sour in taste and neutral in nature. It enters liver and kidney meridians. Dispel stasis and dredge meridians, tonify liver and kidney, strengthen tendons and bones.
Asarum: pungent taste, warm nature and slight toxicity. It enters heart, lung and kidney meridians. Relieving exterior syndrome, dispelling cold, dispelling pathogenic wind, relieving pain, dredging orifices, warming lung, and eliminating phlegm. Has the functions of dispersing yin channel and eliminating dampness in muscles and bones due to wind-cold.
Large-leaved gentian: pungent and bitter in flavor and mild in nature. It enters stomach, liver and gallbladder meridians. Has the functions of dispelling wind-damp, clearing damp-heat, relieving arthralgia, eliminating deficiency-heat, overcoming damp evil, activating collaterals and relaxing tendons.
Tuckahoe, poria cocos: sweet and bland in flavor and mild in nature. It enters heart, lung, spleen and kidney meridians. Induce diuresis and drain dampness, invigorate spleen and calm heart.
A cassia core: pungent and sweet in flavor, warm in nature, replenishing vital essence to improve eyesight, removing blood stasis to promote granulation, tonifying internal injury, warming waist and knees, and reuniting tendons and bones. It is indicated for bone steaming with sweating when wind pathogen is spread to the interior.
Wind prevention: pungent and sweet in flavor, slightly warm in nature. It enters bladder, liver and spleen meridians. Dispel wind and relieve exterior syndrome, expel dampness and relieve pain, relieve spasm, remove meridian dampness and relieve bone pain.
Ginseng: sweet, slightly bitter and neutral in nature. It enters spleen, lung and heart meridians. Tonify primordial qi, recover pulse to stop collapse, tonify spleen and lung, promote fluid production, and induce tranquilization.
Licorice root: sweet in flavor and neutral in nature. It enters heart, lung, spleen and stomach meridians. Invigorating spleen and replenishing qi, clearing away heat and toxic material, eliminating phlegm and relieving cough, relieving spasm and pain, and harmonizing the drugs.
The Chinese angelica tail: sweet and pungent in flavor and warm in nature. It enters liver, heart and spleen meridians. Promoting blood circulation to relieve pain, replenishing blood to regulate menstruation, moistening dryness and lubricating intestines.
Sappan wood: sweet, salty and neutral in nature. It enters heart, liver and spleen meridians. Promoting blood circulation, removing blood stasis, relieving swelling and pain.
White peony root: bitter and sour in taste, slightly cold in nature. It enters liver and spleen meridians. Nourish blood and regulate menstruation, astringe yin and check sweating, soften liver and relieve pain, and calm liver yang.
Dried rehmannia root: sweet and bitter in flavor, slightly cold in nature. Heart, liver and kidney meridians. To nourish yin, clear heat, cool blood and enrich blood.
Ligusticum wallichii: pungent flavor and warm nature. It enters liver, gallbladder and pericardium meridians. Promote blood circulation and move qi, dispel wind and alleviate pain.
Honeysuckle flower: sweet taste, cold nature, entering lung, heart and stomach meridians. Has effects of clearing away heat and toxic materials, relieving inflammation, tonifying deficiency, and treating wind.
The traditional Chinese medicine of the invention mainly uses pubescent angelica root for dispelling wind-damp, relieving pain and relieving exterior syndrome, and is supplemented with asarum, gentiana macrophylla and divaricate saposhnikovia root for strengthening the effects of dispelling wind-damp, relieving pain and relieving exterior syndrome of the pubescent angelica root; then the angelica tail, the sappan wood and the white paeony root are matched to activate blood and remove stasis, and relieve swelling and pain; the ginseng, the cassia bark core and the rhizoma ligustici wallichii are matched to regulate qi activity in multiple aspects of tonifying qi, tonifying qi and promoting qi circulation so as to activate qi and blood to run; the dried rehmannia root and the honeysuckle are compatible with each other to enrich the blood, nourish yin, clear heat, promote the production of body fluid, cool blood, detoxify, tonify deficiency and treat wind; poria cocos is used for promoting diuresis and excreting dampness, so that phlegm-dampness can be prevented from entering collaterals; mistletoe, eucommia bark and achyranthes root are used together for tonifying liver and kidney and strengthening bones and muscles; finally, the liquorice is used for harmonizing the medicines. The medicines are compatible to play the efficacies of tonifying liver and kidney, invigorating qi and blood, dispelling wind-damp and stopping arthralgia. It is especially suitable for treating deficiency of liver and kidney, chronic arthromyodynia, soreness of waist and knees, aversion to cold, difficulty in flexion and extension of limbs, numbness, and numbness.
The invention dispels the evil and strengthens the body resistance, strengthens the muscles and bones, smoothes the adhesion of the meridians and the tendons and the nodules, and simultaneously promotes the repair of the injured meridians, thereby having better efficacy of dredging the meridians and the tendons. In particular, the external application of the invention is applied to the tendons and joints of liver and kidney meridians of foot jueyin and foot shaoyin and connective tissues, and has obvious effects of clearing and activating the channels, promoting blood circulation to remove blood stasis, resisting inflammation and relieving pain. The specific operation method comprises the following steps: the medicine is firstly applied to the parts of the liver meridian tendons of foot jueyin inside the thigh, and then ascends from the interrow and Taichong acupoints with the palm center, so as to find subcutaneous joints. The secondary pain is to the joints and the position where the touch pain is obvious. After the skin absorbs the liquid medicine, the tendon and connective tissue are treated by a professional tool for shifting the tendon.
The traditional Chinese medicine composition is locally used and matched with a tendon poking manipulation, can quickly reach a fascia layer through skin and muscle, and can comprehensively relieve liver and kidney deficiency, muscle weakness and various painful diseases caused by invasion of wind-cold, summer-heat, dampness and dryness-fire, so that the best treatment effect is achieved, and the clinical use curative effect is obvious. Can be used for treating vertigo, tinnitus, soreness of waist and hypochondriac pain caused by deficiency of liver and kidney, deficiency of yin fluid, and deficiency of yin-yang. The invention is an external preparation, avoids the toxic and side effects related to oral administration, and has great advantages in the treatment effect aiming at the problem of the menstrual cramp.
On the basis of the traditional Chinese medicine for dredging and relieving the twelve meridian tendons arthralgia, the traditional Chinese medicine can be prepared into any pharmaceutical formulation suitable for external use by adding conventional auxiliary materials according to a general pharmaceutical method, and preferably can be prepared into an external liniment.
The preparation method of the external liniment for relieving the twelve meridian obstruction syndromes comprises the following steps:
(1) respectively taking the traditional Chinese medicine raw materials, and respectively preparing powder to obtain raw material powder for later use;
(2) uniformly mixing the raw material powders to obtain mixed medicinal powder; adding white spirit into the mixed medicinal powder for soaking, then sequentially carrying out high-temperature high-pressure leaching, concentration and residue filtering to obtain liquid, namely the external liniment for relieving the twelve-meridian arthralgia.
Preferably, in the step (1), the powder is prepared by coarse grinding to particle size of 300-800 μm, and then fine grinding to particle size of less than 1 μm.
Preferably, in the step (2), the white spirit is white spirit with the alcohol degree of more than 52% Vol, the proportion of the mixed medicinal powder to the white spirit is 3-5g:20-30mL, and the soaking is carried out for 6-10 h.
Preferably, in the step (2), the high-temperature high-pressure leaching is carried out for 15-20min at the temperature of 100-120 ℃ and under the pressure of 0.5-1.2 MPa.
Preferably, in the step (2), the concentration is carried out at 60-80 ℃ and 0.06-0.1 Mpa until the relative density is 1.15-1.35.
The preparation method has the advantages of good extraction of effective active ingredients, simple preparation process, stable and controllable process, suitability for large-scale production and application, and quick absorption of the skin, comfortable use and no irritation of the prepared liniment.
For the treatment of diseases of the meridians and tendons, it is commonly used for the treatment of bone setting and traumatic injury in clinic. The invention enlarges the treatment range of the diseases of the muscles and tendons. Most of the common bone-setting and traumatic injury medicines in the market are used for treating the bone and the traumatic injury from the beginning to the foot. The invention clearly distinguishes diseases generated by twelve meridians, is specially used for treating the liver and kidney meridian and tendon impediment diseases caused by liver and kidney deficiency, and has strong pertinence and quick response.
The invention fully exerts the advantages of traditional Chinese medicine and perfects the therapy of treating arthralgia through tendons. Through clinical practice and application, the traditional Chinese medicine has the advantages of fully embodying the holistic view and syndrome differentiation and typing of the traditional Chinese medicine for treating the arthralgia, having obvious curative effect, having no injection or skin breaking, being safe and effective, showing great advantages on long-term treatment effect, and being worthy of clinical popularization and application.
The invention has the beneficial effects that:
1. according to the invention, radix angelicae pubescentis, mistletoe, eucommia ulmoides, achyranthes bidentata, asarum, gentiana macrophylla, poria cocos, cassia bark, divaricate saposhnikovia root, ginseng, liquorice, angelica tail, sappan wood, white paeony root, dried rehmannia, honeysuckle and ligusticum wallichii are adopted as raw materials and are subjected to proper weight proportion, so that the raw materials are mutually compatible and take effects in a synergistic manner, the effects of tonifying liver and kidney, tonifying qi and blood, dispelling wind-damp and relieving arthralgia can be achieved, the pertinence on the dredging of liver and kidney meridians in twelve meridians is strong, the curative effect is obvious, and the effect is quick.
2. The invention adopts the outer skin permeation drug delivery, is safe without toxic and side effects, does not enter the mouth, does not pass through the digestive tract, avoids the first pass effect of the liver, avoids the adverse effect on the human body caused by long-term taking of the oral drug, and protects the internal organs of the liver, the kidney and the like.
3. The invention has the advantages of convenient use and carrying, no pain in the treatment process and wide applicable population.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention will be described in detail below. It is to be understood that the described embodiments are merely a few embodiments of the invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the examples given herein without any inventive step, are within the scope of the present invention.
Example 1
An external liniment for relieving twelve meridian arthralgia is prepared from the following raw materials:
50g of radix angelicae pubescentis, 15g of mistletoe, 30g of eucommia ulmoides, 25g of achyranthes bidentata, 30g of asarum, 30g of gentiana macrophylla, 35g of poria cocos, 28g of cassia bark, 25g of divaricate saposhnikovia root, 30g of ginseng, 25g of liquorice, 30g of angelica sinensis, 22g of sappan wood, 25g of white paeony root, 22g of dried rehmannia root, 20g of honeysuckle and 30g of ligusticum wallichii.
The preparation method comprises the following steps:
(1) respectively taking the traditional Chinese medicine raw materials, respectively coarsely grinding the raw materials until the particle size is 400 mu m, and finely grinding the raw materials until the particle size is less than 1 mu m to obtain raw material fine powder for later use;
(2) uniformly mixing the fine powder of each raw material to obtain mixed medicinal powder; adding 52% Vol white spirit into the mixed medicinal powder according to the proportion of 3g of the mixed medicinal powder to 25mL of the white spirit, soaking for 8h, then sequentially extracting for 15min at the temperature of 110 ℃ and under the pressure of 0.8MPa, concentrating to the relative density of 1.24 at the temperature of 70 ℃ and under the pressure of 0.09MPa, and filtering to remove residues to obtain liquid, namely the external liniment for relieving the twelve-meridian arthralgia syndrome.
Example 2
An external liniment for relieving twelve meridian arthralgia is prepared from the following raw materials:
40g of radix angelicae pubescentis, 20g of mistletoe, 25g of eucommia ulmoides, 30g of achyranthes bidentata, 20g of asarum, 35g of gentiana macrophylla, 30g of poria cocos, 30g of cassia bark, 20g of divaricate saposhnikovia root, 35g of ginseng, 20g of liquorice, 35g of angelica sinensis, 20g of sappan wood, 30g of white paeony root, 20g of dried rehmannia root, 20g of honeysuckle and 35g of ligusticum wallichii.
The preparation method comprises the following steps:
(1) respectively taking the traditional Chinese medicine raw materials, respectively coarsely grinding the raw materials until the particle size is 300 mu m, and finely grinding the raw materials until the particle size is less than 1 mu m to obtain raw material fine powder for later use;
(2) uniformly mixing the fine powder of each raw material to obtain mixed medicinal powder; adding 52% Vol white spirit into the mixed medicinal powder according to the proportion of 3g of the mixed medicinal powder to 20mL of the white spirit, soaking for 6h, then sequentially extracting for 15min at 100 ℃ and 1.2MPa, concentrating to the relative density of 1.15 at 60 ℃ and 0.1MPa, and filtering to remove residues, wherein the obtained liquid is the external liniment for relieving the twelve-meridian arthralgia.
Example 3
An external liniment for relieving twelve meridian arthralgia is prepared from the following raw materials:
60g of radix angelicae pubescentis, 10g of mistletoe, 35g of eucommia ulmoides, 20g of achyranthes bidentata, 45g of asarum, 20g of gentiana macrophylla, 45g of poria cocos, 25g of cassia bark, 30g of divaricate saposhnikovia root, 20g of ginseng, 30g of liquorice, 20g of angelica sinensis, 25g of sappan wood, 20g of white paeony root, 25g of dried rehmannia root, 15g of honeysuckle and 20g of ligusticum wallichii.
The preparation method comprises the following steps:
(1) respectively taking the traditional Chinese medicine raw materials, respectively coarsely grinding the raw materials until the particle size is 800 mu m, and finely grinding the raw materials until the particle size is less than 1 mu m to obtain raw material fine powder for later use;
(2) uniformly mixing the fine powder of each raw material to obtain mixed medicinal powder; adding 52% Vol white spirit into the mixed medicinal powder according to the proportion of 5g of the mixed medicinal powder to 30mL of the white spirit, soaking for 10h, then sequentially extracting for 20min at 120 ℃ and 0.5MPa, concentrating to the relative density of 1.35 at 80 ℃ and 0.06MPa, and filtering to remove residues to obtain liquid, namely the external liniment for relieving the twelve-meridian arthralgia.
Typical cases of treatment
Case one: in 2016, 7 months and 10 days, the doctor visits the knee joint before.
And (4) checking: the knees on the right side are red, swollen, distending pain, leg stretching pain and difficulty in bending and squatting. The muscles of the waist are tensed. Pain affects sleep.
And (3) judging: abnormal contraction of muscle fascia due to sweating, cold catching in lying at night and wind-cold catching, which is an acute attack of rheumatic arthralgia.
The treatment method comprises the following steps: the tendon poking technique was used in combination with the drug of the present invention (example 1).
The treatment process comprises the following steps: after the liniment is applied to the knee of a patient. The two hands press and touch the gallbladder meridian tendon of foot shaoyang, stomach meridian tendon of foot yangming and bladder meridian tendon of foot taiyang along the lateral side of the patient in sequence to find the painful striae and the tendon sections. After the focus and pain point are determined, the liniment is applied. After the liniment is applied, the local pain of a patient is relieved. And (4) loosening and dredging the rib joints on the three warp ribs by using a rib poking tool. The soothing essential oil is added to the muscles and joints without pain points for lubrication, and the liniment is applied to the parts with the striae, the mass and the pain points for three times. The three warp cords are along the course direction, and the combing takes fifteen minutes each. Point treatment: tianxi acupoint, Riyue acupoint, Liangmen acupoint, Wushu acupoint, Weidao acupoint, Fuai acupoint, pylorus acupoint, Jianli acupoint, Guanyuan acupoint, Zusanli, Manghan acupoint and Biguan acupoint.
The treatment effect is as follows: after three times of regulation and treatment, the red and swollen of the right knee of the patient disappear, and the pain is relieved. After seven times, the user can not feel pain when sleeping at night. After twelve consecutive treatment courses, the recovery was as usual.
Case two: li Yi. In 2016, 9 and 21 days, the neck, shoulder and back are sore and sore.
And (4) checking: pain around the shoulders, left-side heavy. It is difficult to reach, lift and bend the elbow. The left high and middle focus of the back has a bulge, which makes muscles tight when touched and pressed, and fascia is adhered.
And (3) judging: the sweat is in the same wind, the person lies and catches a cold at night, and the person works in the air-conditioned room all the year round. Long-term bending over of the desk can cause shoulder and neck strain. Muscular fasciae contraction and relaxation disorder caused by wind-cold belongs to acute attack of rheumatic arthralgia.
The treatment method comprises the following steps: the tendon poking technique was used in combination with the drug of the present invention (example 2).
The treatment process comprises the following steps: the pain is aggravated when the arms are stretched forward, because a plurality of tendons and joints like the mung bean can be touched between the lower corner of the shoulder nail and the armpit of the patient. The shoulder armor has a plurality of cord-like obstructions moving upward and obliquely, and pain occurs when the shoulder armor touches the ground. The liniment is applied to the parts of the two shoulders and the scapula of a patient. And touching and pressing the minor yang triple energizer meridian tendon of the hand, the Mingyang large intestine meridian tendon of the hand and searching for painful chordae and muscle segments by bare hands in sequence. After the focus and pain point are determined, the liniment is applied. After the liniment is applied, the two meridians are dredged by a tendon poking tool, and tendon sections on the meridians are loosened and scraped mainly. The channels and tendons without pain spots are lubricated by the soothing essential oil, and the fingers are pulled. The liniment is applied to the part with the cord, the mass and the pain point for two times and three times according to the size. The tendons and joints caused by qi stagnation can be removed by scraping after the medicine is applied; the block and the rope caused by blood stasis need to be cut and divided. Two warps are each along the course direction, and it takes fifteen minutes to comb. Point treatment: diaphragma, shentang, gaohuang, Jianzhen, Binao, Tianliao, Fengchi, Pao guo, Tianjing, Jianliao and Fengmen.
The treatment effect is as follows: through three times of regulation and treatment, the pain of the arm at the sick side of the patient is relieved. Seven times later, the arms stretch forward and bend backward freely, and the patient can turn over during sleep without pressure pain. Considering the deficiency of both qi and blood of the patient and the blood failing to nourish the muscles, continuous regulation for 3 months is recommended. When the muscles of the spleen and stomach of the abdomen, liver and gallbladder and legs are stirred, the shoulders are recovered to be normal, the face is ruddy, the emotion is comfortable, and the shoulders and the back are recovered to be healthy.
Case three: zhang, 2016, 3 months and 26 days, the physician needs to see the disease before the scapulohumeral periarthritis.
And (4) checking: the pain of the right shoulder is serious, the pain is caused by wind, wood is swollen, and the plaster is not comfortable, and the effect of plaster is not ideal every time because the skin is allergic. The neck and shoulder are checked first, a plurality of points are found by using the muscle poking bar, and the user presses down, wherein some points are painful when touching, and some points are not painful. The extent of the arms extending forward and bending backward was also examined.
The treatment method comprises the following steps: the tendon poking technique was used in combination with the drug of the present invention (example 3).
The treatment process comprises the following steps: the liniment is used for treating the disease focus of the tendon and joint from the left shoulder of the liniment according to the principle of treating the left disease by the right and treating the right disease by the left treatment, and the treatment is continuously carried out for 3 days, 1 and half an hour each time.
The treatment effect is as follows: when the muscle is pulled softly, the muscle has a sense of relaxation, and when the muscle is pulled seriously, the shoulder can feel hard and the gorgeous place emits cold wind. The pain of the right shoulder after treatment is obviously relieved.
Case four: tong the doctor will see a doctor before the scapulohumeral periarthritis is a problem in 12/5/2012.
And (4) checking: after pulse feeling, the physician asked about daily diet, menstruation, stool and urine, and then examined the neck, shoulder and arms.
And (3) judging: liver and kidney yin deficiency, internal cold, dampness, turbidity, toxic and cementation, impairment of blood and qi consumption, and resulting in soreness of joints, tension and pain of shoulder muscles and discomfort of arms due to spasm of muscles.
The treatment method comprises the following steps: the tendon poking technique was used in combination with the drug of the present invention (example 1).
The treatment process comprises the following steps: the liniment is firstly applied to the cervical vertebra and the rich and noble bag, and then is downwards applied along the posterior hairline until reaching the vicinity of the lumbar vertebra. The user can move up and down along with the muscle poking bar, and feels that the back is thin and transparent. Repeatedly poking for 40 minutes, and then beginning to poke the muscles and tendons around the front shoulder. After treatment, the patient feels relaxed all over the body after rising, and the eyes are clear. The muscles on the shoulders and the back are relaxed, when the arms rotate, the arms feel astringent, people do not need to take a bath after two days, and the people pay attention to keeping warm, wear a hat and wear a neck. Later, the adjustment is carried out for more than ten times continuously, and each time lasts for 60-90 minutes.
The treatment effect is as follows: the scapulohumeral periarthritis is cured.
The above description is only for the specific embodiments of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art can easily conceive of the changes or substitutions within the technical scope of the present invention, and all the changes or substitutions should be covered within the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the appended claims.
Claims (10)
1. The traditional Chinese medicine for treating the twelve meridian arthralgia is characterized by comprising the following raw material components:
radix angelicae pubescentis, mistletoe, eucommia ulmoides, achyranthes bidentata, asarum, gentiana macrophylla, poria cocos, cassia bark, radix sileris, ginseng, liquorice, angelica sinensis, sappan wood, radix paeoniae alba, dried rehmannia, honeysuckle and ligusticum wallichii.
2. The traditional Chinese medicine for dredging meridian obstruction syndrome according to claim 1, which is characterized by comprising the following raw materials in parts by weight:
40-60 parts of radix angelicae pubescentis, 10-20 parts of mistletoe, 25-35 parts of eucommia ulmoides, 20-30 parts of radix achyranthis bidentatae, 20-45 parts of asarum, 20-35 parts of radix gentianae macrophyllae, 30-45 parts of poria cocos, 25-30 parts of cassia bark, 20-30 parts of radix sileris, 20-35 parts of ginseng, 20-30 parts of liquorice, 20-35 parts of angelica tail, 20-25 parts of sappan wood, 20-30 parts of radix paeoniae alba, 20-25 parts of dried rehmannia, 15-20 parts of honeysuckle and 20-35 parts of ligusticum wallichii.
3. The traditional Chinese medicine for treating twelve meridian arthralgia according to claim 1, wherein the traditional Chinese medicine for treating twelve meridian arthralgia is in the form of an external liniment.
4. The method for preparing the external liniment for relieving twelve meridian obstruction of claim 3, which comprises the following steps:
(1) respectively taking the traditional Chinese medicine raw materials, and respectively preparing powder to obtain raw material powder for later use;
(2) uniformly mixing the raw material powders to obtain mixed medicinal powder; adding white spirit into the mixed medicinal powder for soaking, then sequentially carrying out high-temperature high-pressure leaching, concentration and residue filtering to obtain liquid, namely the external liniment for relieving the twelve-meridian arthralgia.
5. The method for preparing the liniment according to claim 4, wherein in the step (1), the powder is prepared by coarse pulverization to particle size of 300-800 μm, and then fine pulverization to particle size of less than 1 μm.
6. The preparation method of the external liniment for dredging twelve meridian arthralgia according to claim 4, wherein in the step (2), the white spirit with the alcohol degree of more than 52% Vol is adopted, the ratio of the mixed powder to the white spirit is 3-5g to 20-30mL, and the soaking is carried out for 6-10 h.
7. The method for preparing the liniment for external use for relieving twelve meridian arthralgia according to claim 4, wherein in the step (2), the high-temperature high-pressure leaching is performed for 15-20min at a temperature of 100 ℃ and 120 ℃ and under a pressure of 0.5-1.2 MPa.
8. The method for preparing the liniment for external use for relieving twelve meridian obstruction syndrome according to claim 4, wherein in the step (2), the concentration is carried out at 60-80 ℃ and 0.06-0.1 Mpa until the relative density is 1.15-1.35.
9. The use of the Chinese medicament for treating twelve meridian obstruction syndrome according to claim 1 or 2 in the preparation of medicaments for treating liver-kidney deficiency type obstruction syndrome.
10. The use according to claim 9, wherein the liver-kidney deficiency type arthralgia syndrome includes the symptoms of joint flexion and extension difficulty, soreness and weakness of waist and knees, intolerance of cold, cold limbs, vertigo and tinnitus.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210826278.9A CN115040588A (en) | 2022-07-14 | 2022-07-14 | Traditional Chinese medicine for relieving twelve meridian arthralgia, preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210826278.9A CN115040588A (en) | 2022-07-14 | 2022-07-14 | Traditional Chinese medicine for relieving twelve meridian arthralgia, preparation method and application thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN115040588A true CN115040588A (en) | 2022-09-13 |
Family
ID=83165397
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210826278.9A Pending CN115040588A (en) | 2022-07-14 | 2022-07-14 | Traditional Chinese medicine for relieving twelve meridian arthralgia, preparation method and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN115040588A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1966003A (en) * | 2006-11-22 | 2007-05-23 | 姜方森 | Externally applied medicament for treating rheumatism |
| CN104560567A (en) * | 2015-01-06 | 2015-04-29 | 曹晓凤 | Medicated wine for treating lingering arthralgia and weakened body resistance and application thereof |
| CN105267706A (en) * | 2015-10-19 | 2016-01-27 | 郭世昌 | Traditional Chinese medicine preparation for treating hyperostosis |
-
2022
- 2022-07-14 CN CN202210826278.9A patent/CN115040588A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1966003A (en) * | 2006-11-22 | 2007-05-23 | 姜方森 | Externally applied medicament for treating rheumatism |
| CN104560567A (en) * | 2015-01-06 | 2015-04-29 | 曹晓凤 | Medicated wine for treating lingering arthralgia and weakened body resistance and application thereof |
| CN105267706A (en) * | 2015-10-19 | 2016-01-27 | 郭世昌 | Traditional Chinese medicine preparation for treating hyperostosis |
Non-Patent Citations (1)
| Title |
|---|
| 程志安 等: "独活寄生汤治疗老年性腰膝疼痛临证体悟" * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104398603A (en) | Chinese herbal medicinal hot compress treatment bag for lumbar vertebra, lumbar vertebra and leg joints, and use method thereof | |
| CN102600264B (en) | Externally-applied traditional Chinese medical composition for treatment of orthopedic diseases | |
| CN103550685B (en) | A kind of Chinese medicine composition for the treatment of lumbago and skelalgia | |
| CN106266939A (en) | A kind of Chinese medicine composition, the transdermal patch for neck waist rehabilitation comprising this Chinese medicine composition and preparation and application | |
| CN105920570A (en) | Quick-acting externally applied traditional Chinese medicine for treating rheumatoid bone diseases and preparation method | |
| CN102949680B (en) | Medicinal liquor for treating cervical spondylosis and preparation method thereof | |
| CN104027532A (en) | Traditional Chinese medicine fomentation paste for treating rheumatism | |
| CN103169822A (en) | Synovitis hui-nationality ointment and preparation method thereof | |
| CN103356953B (en) | A kind of Chinese medicine composition for the treatment of lumbar muscle strain | |
| CN102125641B (en) | Externally applied medicament for treating lumbar intervertebral disc protrusion | |
| CN107536901A (en) | A kind of bubble pin health-care Chinese medicinal composition of dispersing blood stasis promoting blood circulation and stopping pain and preparation method thereof | |
| CN104274630A (en) | Formula of traditional Chinese medicine for preventing hair loss and promoting hair growth and preparation method thereof | |
| CN115040588A (en) | Traditional Chinese medicine for relieving twelve meridian arthralgia, preparation method and application thereof | |
| CN101502604B (en) | Chinese herbal medicine preparation for treating rheumatism | |
| CN104971286A (en) | Traditional Chinese medicine composition for treating shoulder, waist and leg discomfort | |
| CN109806351A (en) | Neck-shoulder pain, lumbago and leg pain temperature, which is applied, to be dissipated | |
| CN108939015A (en) | Cervical vertebra restores medicinal pillow inner | |
| CN104027451B (en) | A kind of Chinese medicine for the treatment of deficiency of the liver and kindey pattern of syndrome sciatica | |
| CN103191247A (en) | Traditional Chinese medicine bag for stone needle ironing moxibustion | |
| CN108686146A (en) | A kind of Dressed plaster promoting blood circulation and removing blood stasis and preparation method thereof | |
| CN116492412B (en) | Traditional Chinese medicine composition for treating peripheral neuritis with blood deficiency and collateral obstruction syndrome | |
| CN102406789B (en) | Plaster for treating cervical spondylosis | |
| CN109646657B (en) | Chinese herbal medicine decoction for treating spinal neuron neuritis | |
| CN106924704A (en) | A kind of cervical vertebra plaster formula and its patch preparation method | |
| CN106109965A (en) | A kind of Chinese medicine composition treating flaccidity disease |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20220913 |
|
| RJ01 | Rejection of invention patent application after publication |