CN115040235A - Synchronous multi-path multi-polarity steep pulse generation method for tissue ablation - Google Patents
Synchronous multi-path multi-polarity steep pulse generation method for tissue ablation Download PDFInfo
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- A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
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Abstract
The invention provides a synchronous multi-path multi-polarity steep pulse generation method for tissue ablation, which comprises an energy storage device, a switch, a transmission line group and a load. The transmission line group is mainly characterized in that the transmission line group is composed of a plurality of transmission lines which are connected in parallel or in series, the input end of the transmission line group is connected with the energy storage device in series through the switch, and the inner conductors at the output end of the transmission line group respectively form ground potentials with different polarities. The transmission line can independently drive the loads and respectively output steep pulses with different polarities on different loads; two transmission lines with opposite potential polarities of the inner conductors can be connected in series to cooperatively drive the load, and synchronous bipolar steep pulses are respectively output on different loads. The invention creatively provides a synchronous multi-path multi-polarity steep pulse generation method for tissue ablation, which can be widely applied to the treatment of various tumors and lesion tissues in a human body.
Description
Technical Field
The invention relates to the field of electromagnetic field tumor treatment in medical instruments, in particular to high-voltage pulse electric field tumor tissue ablation and cell treatment.
Background
Cancer seriously jeopardizes human life and health. Thermal ablation therapy, represented by radiofrequency, is limited in its clinical applicability by the effect of thermal sedimentation of the solution in the surrounding tubular structure. The recent advent of ablation therapy based on irreversible electroporation is a new type of non-thermal ablation technique that uses high voltage pulsed electric fields to irreversibly electroporate cell membranes to achieve tumor ablation. Compared with the thermal ablation technology, the ablation boundary is clear, the damage to important structures such as blood vessels, bile ducts, nerves and the like can be effectively avoided, more tumor patients can obtain treatment opportunities, and the remarkable clinical effect is achieved.
The voltage waveform adopted by the pulsed electric field ablation device is mainly unipolar pulse, bipolar pulse or pulse combination, and the pulse width is from nanosecond to microsecond. In practical operation, at least one pair of ablation electrode needles is needed, ablation voltage is inversely related to pulse width, the narrower pulse is, the higher the ablation voltage threshold is, the larger the voltage is, the larger the ablation range is, but too high voltage is easy to cause breakdown of tissues or insulating layers between the electrode needles, so that the ablation range of a single pair of electrode needles is limited, and the position of the electrode needles needs to be adjusted for many times in the ablation process for tumor tissues with larger volume or tissues with irregular shapes. In order to obtain a large ablation area, a multi-electrode needle layout is adopted clinically. The existing ablation device outputs high-voltage pulses to different electrode pairs one by one through a quick switching device (such as patents 2020112024303 and 201910247941.8), the operation process is complex, the treatment time is increased, and the risk of a patient in the operation is also increased; in addition, the polarity of the high-voltage electrode needle in the existing ablation device to the ground potential is the same, so that an effective ablation electric field cannot be formed between the high-voltage electrodes, and the formation of an effective ablation electric field network is not facilitated, so that the ablation range is influenced.
Disclosure of Invention
Aiming at the technical defects of the pulse ablation, the invention creatively provides a novel synchronous multi-path multi-polarity pulse generation method for tissue ablation.
A synchronous multi-path multi-polarity pulse generating device comprises an energy storage device, a switch, a load and a transmission line group, and is characterized in that the transmission line group is composed of a plurality of transmission lines which are connected in parallel or in series, the input end of the transmission line group is connected with the energy storage device in series through the switch, earth potentials with different polarities are respectively formed on inner conductors at the output end of the transmission line group, each transmission line can independently drive the load, and steep pulses with different polarities are respectively output on different loads; two transmission lines with opposite polarities of inner conductors can be connected in series to cooperatively drive the load, and synchronous bipolar steep pulses are respectively output on different loads.
When the number of the transmission line groups is even, the outer conductors at the input ends of the transmission line groups are grounded in parallel; and when the number of the transmission line groups is odd, the outer conductors at the output ends of the transmission line groups are grounded in parallel.
The number of the switches can be single or two, and when the number of the switches is two, two ends of the energy storage device are respectively connected with the input end of the transmission line group through the switches.
The switch, its characterized in that: including but not limited to spark gap switches, magnetic switches, semiconductor switches, etc.
The energy storage device includes but is not limited to a capacitor, a pulse forming line, an artificial forming line, a pulse generator and the like.
Such loads include, but are not limited to, biological tissues, tumors, cells, microorganisms, and the like.
The invention creatively provides a synchronous multi-path multi-polarity pulse generation method, which has the advantages that: the multi-channel multi-polarity pulse synchronous output can be realized, and the electrodes can flexibly and variously select the ground potential polarity and can be positive, negative or zero potential; an effective ablation electric field network is easily formed between the electrode needles, and large-volume tumor tissues or irregular focus tissues can be covered at one time; the electrodes with opposite potential polarities can act synergistically, so that the voltage of the electrodes is reduced by half aiming at the ground on the premise of ensuring the ablation range, the insulation requirement of the pulse generating equipment on the ground is greatly reduced, and the pulse generating equipment is safer and more reliable. In addition, based on the Faraday cage electromagnetic shielding effect, the important organs near the ablation area can be protected from the influence of an external electric field by adopting the zero-potential electrode needle array.
Drawings
FIG. 1 shows an embodiment of the present invention based on a single bipolar pulse output of two transmission lines.
Fig. 2 is a pulse voltage waveform of a single bipolar pulse output based on two-stage transmission lines according to the present invention.
Fig. 3 is an embodiment of two independent positive and negative pulse outputs based on two stages of transmission lines according to the present invention.
Fig. 4 shows an embodiment of two bipolar pulse outputs based on a three-stage transmission line according to the present invention.
Fig. 5 is an embodiment of three independent positive and negative pulse outputs based on a three-stage transmission line according to the invention.
Fig. 6 is an embodiment of four independent positive and negative pulse outputs based on four-stage transmission lines connected in parallel according to the invention.
Fig. 7 shows an embodiment of the invention based on two bipolar pulse outputs connected in parallel by a four-stage transmission line.
Fig. 8 is an embodiment of two bipolar pulse outputs based on four-stage transmission line series connection according to the present invention.
Fig. 9 is an embodiment of four independent positive and negative pulse outputs based on four-stage transmission line series connection according to the invention.
FIG. 10 shows an embodiment of the present invention based on a two-stage transmission line for single bipolar pulse output ablation of liver tumors.
FIG. 11 is a schematic cross-sectional view of the two-stage transmission line based single-channel bipolar pulse output ablation liver tumor range.
FIG. 12 is a diagram of an embodiment of the present invention based on two independent positive and negative pulse outputs of a two-stage transmission line for ablating liver tumors.
FIG. 13 is a schematic cross-sectional view of the present invention based on two independent positive and negative pulse outputs of a two-stage transmission line to ablate the liver tumor area.
FIG. 14 is an embodiment of the present invention based on two-stage transmission line two-way independent positive and negative pulse output ablation of liver tumor of specific shape.
FIG. 15 is a schematic cross-sectional view of the present invention based on two independent positive and negative pulse outputs of two-stage transmission lines for ablating irregular liver tumors.
Fig. 16 is an embodiment of the present invention based on pulse forming line energy storage.
Fig. 17 is an embodiment of the present invention based on artificially formed wire energy storage.
Fig. 18 is a diagram of a dual switch multiplexed output based embodiment of the present invention.
Fig. 19 is an embodiment of the present invention based on Blumlein pulse forming lines.
In the figure: 1. a capacitive energy storage device; 2. a switch; 3. a transmission line; 4. an input end inner conductor of the transmission line; 5. a transmission line; 6. an input end inner conductor of the transmission line; 7. an outer conductor of the transmission line input end; 8. an outer conductor of the transmission line input end; 9. grounding; 10. a load; 11. an inner conductor at the output end of the transmission line; 12. an inner conductor at the output end of the transmission line; 13. an outer conductor of the transmission line output end; 14. an outer conductor of the transmission line output end; 15. a positive polarity pulse waveform; 16. a negative polarity pulse waveform; 17. pulse voltage waveforms at two ends of the load; 18. a load; 19. a load; 20. a transmission line; 21. a transmission line; 22. an outer conductor of the transmission line input end; 23. an input end inner conductor of the transmission line; 24. an input end inner conductor of the transmission line; 25. an input end outer conductor of the transmission line; 26. a load; 27. a load; 28. an inner conductor at the output end of the transmission line; 29. an outer conductor of the transmission line output end; 30. an inner conductor at the output end of the transmission line; 31. an outer conductor of the transmission line output end; 32. grounding; 33. a load; 34. a load; 35. a load; 36. a transmission line; 37. a transmission line; 38. a transmission line; 39. an input end inner conductor of the transmission line; 40. an outer conductor of the transmission line input end; 41. an input end inner conductor of the transmission line; 42. an outer conductor of the transmission line input end; 43. an input end inner conductor of the transmission line; 44. an input end outer conductor of the transmission line; 45. grounding; 46. a load; 47. a load; 48. a load; 49. a load; 50. an inner conductor at the output end of the transmission line; 51. an outer conductor of the transmission line output end; 52. an inner conductor at the output end of the transmission line; 53. an outer conductor of the transmission line output end; 54. an inner conductor at the output end of the transmission line; 55. an outer conductor of the transmission line output end; 56. a load; 57. a load; 58. a liver; 59. intrahepatic tumors; 60. an electrode needle; 61. an electrode needle; 62. an electrode needle; 63. an electrode needle; 64. the range of electric field action; 65. a pulse forming line energy storage device; 66. manually forming a linear energy storage device; 67. a switch; 68. the Blumlein pulse forms a line.
Detailed Description
In order to more specifically describe the present invention, the following detailed description is provided for the technical solution of the present invention with reference to the accompanying drawings and the specific embodiments.
Example 1
As shown in figure 1, a multi-path multi-polarity steep pulse generation method for tissue ablation comprises an energy storage device 1, a switch 2, a transmission line 3, a transmission line 5 and a load 10, wherein the energy storage device 1 is a capacitor, and is characterized in that one end of the energy storage device 1 is connected with an inner conductor 4 at the input end of the transmission line 3 through the switch 2, the other end of the energy storage device 1 is connected with an inner conductor 6 at the input end of the transmission line 5, an outer conductor 7 at the input end of the transmission line 3 is connected with an outer conductor 8 at the input end of the transmission line 5 and is connected with a ground 9, two ends of the load 10 are respectively connected with an inner conductor 11 at the output end of the transmission line 3 and an inner conductor 12 at the output end of the transmission line 5, an outer conductor 13 at the output end of the transmission line 3 is connected with an outer conductor 14 at the output end of the transmission line 5, unipolar pulse is output on the load 10, but the potentials at the two ends of the load are opposite in polarity, and the amplitude is half of the voltage V on the energy storage device 1, the voltage waveform diagram is shown in fig. 2, the waveform 16 is the output voltage waveform of the inner conductor 12 at the output end of the transmission line 5 to the ground, the amplitude is-V/2, the waveform 15 is the output voltage waveform of the inner conductor 11 at the output end of the transmission line 3 to the ground, the amplitude is + V/2, the waveform 17 is the pulse voltage waveform at both ends of the load 10, and the amplitude is V.
Example 2
As shown in figure 3, a multi-path multi-polarity steep pulse generation method for tissue ablation comprises an energy storage device 1, a switch 2, a transmission line 3, a transmission line 5, a load 18 and a load 19, wherein the energy storage device 1 is a capacitor, and is characterized in that one end of the energy storage device 1 is connected with an inner conductor 4 at the input end of the transmission line 3 through the switch 2, the other end of the energy storage device 1 is connected with an inner conductor 6 at the input end of the transmission line 5, an outer conductor 7 at the input end of the transmission line 3 is connected with an outer conductor 8 at the input end of the transmission line 5 and is connected with a ground 9, two ends of the load 18 are respectively connected with an inner conductor 11 and an outer conductor 13 at the output end of the transmission line 3, a positive high-voltage pulse with an amplitude of half of a voltage V (namely + V/2) on the energy storage device 1 is output by the load 18, two ends of the load 19 are respectively connected with an inner conductor 12 and an outer conductor 14 at the output end of the transmission line 5, a negative high voltage pulse is output on the load 19 with an amplitude of half the voltage V on the energy storage device 1, i.e. -V/2.
Example 3
As shown in fig. 4, a multi-path multi-polarity steep pulse generation method for tissue ablation comprises an energy storage device 1, a switch 2, a transmission line 3, a transmission line 20, a transmission line 21, a load 26 and a load 27, wherein the energy storage device 1 is a capacitor, and is characterized in that one end of the energy storage device 1 is connected with an inner conductor 4 at the input end of the transmission line 3 through the switch 2, and the other end of the energy storage device 1 is connected with an outer conductor 25 at the input end of the transmission line 21; the outer conductor 7 at the input end of the transmission line 3 is connected to the outer conductor 22 at the input end of the transmission line 20; the inner conductor 23 at the input end of the transmission line 20 is connected with the inner conductor 24 at the input end of the transmission line 21, two ends of a load 26 are respectively connected with the inner conductor 11 at the output end of the transmission line 3 and the inner conductor 28 at the output end of the transmission line 20, a high-voltage pulse is output on the load 26, the amplitude is 2V/3 of the voltage V on the energy storage device 1, two ends of the load 27 are respectively connected with the inner conductor 28 at the output end of the transmission line 20 and the inner conductor 30 at the output end of the transmission line 21, a high-voltage pulse is output on the load 27, the amplitude is 2V/3 of the voltage V on the energy storage device 1, the outer conductor 13 at the output end of the transmission line 3, the outer conductor 29 at the output end of the transmission line 20 and the outer conductor 31 at the output end of the transmission line 21 are connected together and then connected with the ground 32, and the potentials of the inner conductor 11 at the output end of the transmission line 3, the inner conductor 28 at the output end of the transmission line 20 and the inner conductor 30 at the output end of the transmission line 21 are respectively + V/3, -V/3, + V/3.
Example 4
As shown in fig. 5, a multi-path multi-polarity steep pulse generation method for tissue ablation comprises an energy storage device 1, a switch 2, a transmission line 3, a transmission line 20, a transmission line 21, a load 33, a load 34 and a load 35, wherein the energy storage device 1 is a capacitor, and is characterized in that one end of the energy storage device 1 is connected with an inner conductor 4 at the input end of the transmission line 3 through the switch 2, and the other end of the energy storage device 1 is connected with an outer conductor 25 at the input end of the transmission line 21; the outer conductor 7 at the input end of the transmission line 3 is connected with the outer conductor 22 at the input end of the transmission line 20; the inner conductor 23 at the input end of the transmission line 20 is connected with the inner conductor 24 at the input end of the transmission line 21, the outer conductor 13 at the output end of the transmission line 3, the outer conductor 29 at the output end of the transmission line 20 and the outer conductor 31 at the output end of the transmission line 21 are connected together and then connected with the ground 32, two ends of the load 33 are respectively connected with the inner conductor 11 and the outer conductor 13 at the output end of the transmission line 3, high-voltage pulses with the amplitude of 1/3 (V/3) of the voltage V on the energy storage device 1 are output on the load 33, two ends of the load 34 are respectively connected with the inner conductor 28 and the outer conductor 29 at the output end of the transmission line 20, high-voltage pulses with the amplitude of-1/3 (V/3) of the voltage V on the energy storage device 1 are output on the load 34, two ends of the load 35 are respectively connected with the inner conductor 30 and the outer conductor 31 at the output end of the transmission line 21, and the high-voltage pulses are output on the load 35, the amplitude is 1/3, i.e. V/3, of the voltage V across the energy storage device 1.
Example 5
As shown in fig. 6, a multi-channel multi-polarity steep pulse generation method for tissue ablation comprises an energy storage device 1, a switch 2, a transmission line 3, a transmission line 36, a transmission line 37, a transmission line 38, a load 46, a load 47, a load 48 and a load 49, wherein the energy storage device 1 is a capacitor, and is characterized in that one end of the energy storage device 1 is connected with an inner conductor 4 at the input end of the transmission line 3 through the switch 2, and the other end of the energy storage device 1 is connected with an inner conductor 43 at the input end of the transmission line 38; the outer conductor 7 at the input end of the transmission line 3, the outer conductor 40 at the input end of the transmission line 36, the outer conductor 42 at the input end of the transmission line 37 and the outer conductor 44 at the input end of the transmission line 38 are connected together and then are connected with the ground 45; the inner conductor 4 at the input of transmission line 3 is connected to the inner conductor 39 at the input of transmission line 36; the inner conductor 41 at the input end of the transmission line 37 is connected with the inner conductor 43 at the input end of the transmission line 38, the outer conductor 13 at the output end of the transmission line 3, the outer conductor 51 at the output end of the transmission line 36, the outer conductor 53 at the output end of the transmission line 37 are connected together, the outer conductor 55 at the output end of the transmission line 38 is connected together, two ends of the load 46 are respectively connected with the inner conductor 11 and the outer conductor 13 at the output end of the transmission line 3, high-voltage pulses with the amplitude of 1/2, namely V/2, of the voltage V on the energy storage device 1 are output on the load 46, two ends of the load 47 are respectively connected with the inner conductor 50 and the outer conductor 51 at the output end of the transmission line 36, high-voltage pulses with the amplitude of 1/2, namely V/2, of the voltage V on the energy storage device 1 are output on the load 47, two ends of the load 48 are respectively connected with the inner conductor 52 and the outer conductor 53 at the output end of the transmission line 37, and the high-voltage pulses are output on the load 48, the amplitude is-1/2, namely-V/2, of the voltage V on the energy storage device 1, two ends of the load 49 are respectively connected with the inner conductor 54 and the outer conductor 55 at the output end of the transmission line 38, and high-voltage pulses with the amplitude of-1/2, namely V/2, of the voltage V on the energy storage device 1 are output on the load 49.
Example 6
As shown in fig. 7, a multi-path multi-polarity steep pulse generation method for tissue ablation comprises an energy storage device 1, a switch 2, a transmission line 3, a transmission line 36, a transmission line 37, a transmission line 38, a load 56 and a load 57, wherein the energy storage device 1 is a capacitor, and is characterized in that one end of the energy storage device 1 is connected with an inner conductor 4 at the input end of the transmission line 3 through the switch 2, and the other end of the energy storage device 1 is connected with an inner conductor 43 at the input end of the transmission line 38; the outer conductor 7 at the input end of the transmission line 3, the outer conductor 40 at the input end of the transmission line 36, the outer conductor 42 at the input end of the transmission line 37 and the outer conductor 44 at the input end of the transmission line 38 are connected together and then connected with the ground 45; the inner conductor 4 at the input of the transmission line 3 is connected to the inner conductor 39 at the input of the transmission line 36; the inner conductor 41 at the input end of the transmission line 37 is connected with the inner conductor 43 at the input end of the transmission line 38, the outer conductor 13 at the output end of the transmission line 3, the outer conductor 51 at the output end of the transmission line 36 and the outer conductor 53 at the output end of the transmission line 37 are connected together, the outer conductor 55 at the output end of the transmission line 38 is connected together, two ends of a load 56 are respectively connected with the inner conductor 11 at the output end of the transmission line 3 and the inner conductor 54 at the output end of the transmission line 38, a high-voltage pulse is output on the load 56, and the amplitude is equal to the voltage V on the energy storage device 1; the potentials of the inner conductor 11 at the output end of the transmission line 3 and the potential of the inner conductor 54 at the output end of the transmission line 38 are + V/2 and-V/2 respectively, two ends of a load 57 are connected with the inner conductor 50 at the output end of the transmission line 36 and the inner conductor 52 at the output end of the transmission line 37 respectively, high-voltage pulses are output on the load 57, and the amplitude is equal to the voltage V on the energy storage device 1; the potentials of the inner conductor 50 at the output end of the transmission line 36 and the inner conductor 52 at the output end of the transmission line 37 are + V/2 and-V/2, respectively.
Example 7
As shown in fig. 8, a multi-path multi-polarity steep pulse generation method for tissue ablation comprises an energy storage device 1, a switch 2, a transmission line 3, a transmission line 36, a transmission line 37, a transmission line 38, a load 56 and a load 57, wherein the energy storage device 1 is a capacitor, and is characterized in that one end of the energy storage device 1 is connected with an inner conductor 4 at the input end of the transmission line 3 through the switch 2, and the other end of the energy storage device 1 is connected with an inner conductor 43 at the input end of the transmission line 38; the outer conductor 7 at the input end of the transmission line 3 is connected with the outer conductor 40 at the input end of the transmission line 36; the outer conductor 42 at the input of transmission line 37 is connected to the outer conductor 44 at the input of transmission line 38; the inner conductor 39 at the input end of the transmission line 36 is connected with the inner conductor 41 at the input end of the transmission line 37, the outer conductor 13 at the output end of the transmission line 3, the outer conductor 51 at the output end of the transmission line 36 and the outer conductor 53 at the output end of the transmission line 37 are connected together, the outer conductor 55 at the output end of the transmission line 38 is connected with the ground 45, two ends of a load 56 are respectively connected with the inner conductor 11 at the output end of the transmission line 3 and the inner conductor 54 at the output end of the transmission line 38, a high-voltage pulse is output on the load 56, and the amplitude of the high-voltage pulse is 1/2 of the voltage V on the energy storage device 1; the potentials of the inner conductor 11 at the output end of the transmission line 3 and the potential of the inner conductor 54 at the output end of the transmission line 38 are + V/4 and-V/4 respectively, two ends of a load 57 are connected with the inner conductor 50 at the output end of the transmission line 36 and the inner conductor 52 at the output end of the transmission line 37 respectively, high-voltage pulses with the amplitude value of 1/2 of the voltage V on the energy storage device 1 are output on the load 57; the potentials of the inner conductor 50 at the output end of the transmission line 36 and the inner conductor 52 at the output end of the transmission line 37 are-V/4 and + V/4, respectively.
Example 8
As shown in fig. 9, a multi-channel multi-polarity steep pulse generation method for tissue ablation comprises an energy storage device 1, a switch 2, a transmission line 3, a transmission line 36, a transmission line 37, a transmission line 38, a load 46, a load 47, a load 48 and a load 49, wherein the energy storage device 1 is a capacitor, and is characterized in that one end of the energy storage device 1 is connected with an inner conductor 4 at the input end of the transmission line 3 through the switch 2, and the other end of the energy storage device 1 is connected with an inner conductor 43 at the input end of the transmission line 38; the outer conductor 7 at the input end of the transmission line 3 is connected with the outer conductor 40 at the input end of the transmission line 36; the outer conductor 42 at the input of transmission line 37 is connected to the outer conductor 44 at the input of transmission line 38; the inner conductor 39 at the input end of the transmission line 36 is connected with the inner conductor 41 at the input end of the transmission line 37, the outer conductor 13 at the output end of the transmission line 3, the outer conductor 51 at the output end of the transmission line 36, the outer conductor 53 at the output end of the transmission line 37 are connected together, the outer conductor 55 at the output end of the transmission line 38 is connected with the ground 45, two ends of the load 46 are respectively connected with the inner conductor 11 and the outer conductor 13 at the output end of the transmission line 3, high-voltage pulses with the amplitude of +1/4 of the voltage V on the energy storage device 1 are output on the load 46, two ends of the load 47 are respectively connected with the inner conductor 50 and the outer conductor 51 at the output end of the transmission line 36, high-voltage pulses with the amplitude of-1/4 of the voltage V on the energy storage device 1 are output on the load 47, two ends of the load 48 are respectively connected with the inner conductor 52 and the outer conductor 53 at the output end of the transmission line 37, and high-voltage pulses are output on the load 48, the amplitude is +1/4 of the voltage V on the energy storage device 1, two ends of the load 49 are respectively connected with the inner conductor 54 and the outer conductor 55 of the output end of the transmission line 38, high-voltage pulses are output on the load 49, and the amplitude is-1/4 of the voltage V on the energy storage device 1.
Example 9
As shown in fig. 10, a multi-channel multi-polarity steep pulse generation method for tissue ablation, comprising an energy storage device 1, a switch 2, a transmission line 3, a transmission line 5, a liver 58, an intrahepatic tumor 59, an electrode needle 60, an electrode needle 61, wherein the electrode needles 60 and 61 are provided with an insulating layer and a discharge front end, the electrode needle 60 and the electrode needle 61 are parallel to each other, characterized in that one end of the energy storage device 1 is connected with an inner conductor 4 at the input end of the transmission line 3 through the switch 2, the other end of the energy storage device 1 is connected with an inner conductor 6 at the input end of the transmission line 5, an outer conductor 7 at the input end of the transmission line 3 is connected with an outer conductor 8 at the input end of the transmission line 5 and is connected with a ground 9, an inner conductor 11 at the output end of the transmission line 3 and an inner conductor 12 at the output end of the transmission line 5 are respectively connected with the electrode needle 60 and the electrode needle 61, the electrode needle 60 and the electrode needle 61 are inserted into the liver 58, as shown in fig. 11, the field coverage 64 covers the intrahepatic tumor 59.
Example 9
As shown in figure 12, a multi-path multi-polarity steep pulse generation method for tissue ablation comprises an energy storage device 1, a switch 2, a transmission line 3, a transmission line 5, a liver 58, an intrahepatic tumor 59, an electrode needle 60, an electrode needle 61, an electrode needle 62 and an electrode needle 63, wherein the electrode needles 60, 61, 62 and 63 are provided with insulating layers and discharge front ends, and the electrode needles 60, 61, 62 and 63 are parallel to each other, and is characterized in that one end of the energy storage device 1 is connected with an inner conductor 4 at the input end of the transmission line 3 through the switch 2, the other end of the energy storage device 1 is connected with an inner conductor 6 at the input end of the transmission line 5, an outer conductor 7 at the input end of the transmission line 3 is connected with an outer conductor 8 at the input end of the transmission line 5 and is connected with a ground 9, an inner conductor 11 at the output end of the transmission line 3 and an inner conductor 12 at the output end of the transmission line 5 are respectively connected with the electrode needle 60 and the electrode needle 61, and an outer conductor 13 at the output end of the transmission line 3 and an outer conductor 14 at the output end of the transmission line 5 are respectively connected with the electrode needle 62 and the electrode needle 63 In connection with this, the electrode needles 60, 61, 62, 63 are inserted into the liver 58, as shown in fig. 13, and the field of action 64 covers the intrahepatic tumor 59.
Example 11
As shown in fig. 14, a multi-channel multi-polarity steep pulse generation method for tissue ablation comprises an energy storage device 1, a switch 2, a transmission line 3, a transmission line 5, a liver 58, an intrahepatic tumor 59, an electrode needle 60, an electrode needle 61, an electrode needle 62 and an electrode needle 63, wherein the electrode needles 60, 61, 62 and 63 are provided with insulating layers and discharge front ends, and the electrode needles 60, 61, 62 and 63 are parallel to each other, and is characterized in that one end of the energy storage device 1 is connected with an inner conductor 4 at the input end of the transmission line 3 through the switch 2, the other end of the energy storage device 1 is connected with an inner conductor 6 at the input end of the transmission line 5, an outer conductor 7 at the input end of the transmission line 3 is connected with an outer conductor 8 at the input end of the transmission line 5 and is connected with a ground 9, an inner conductor 11 at the output end of the transmission line 3 and an inner conductor 12 at the output end of the transmission line 5 are respectively connected with the electrode needle 60 and the electrode needle 61, and an outer conductor 13 at the output end of the transmission line 3 and an outer conductor 14 at the output end of the transmission line 5 are respectively connected with the electrode needle 62 and the electrode needle 63 Even, the electrode needles 60, 61, 62, 63 are inserted into the liver 58, as shown in fig. 15, the electric field action range 64 covers the intrahepatic tumor 59, and according to the arrangement of the electrode needles, the ablation of irregular-shaped tissues can be realized, and the electric field shielding and protection of important tissue structures can be realized through the arrangement of the grounding electrodes.
Example 12
As shown in fig. 16, a multi-channel multi-polarity steep pulse generation method for tissue ablation comprises an energy storage device 65, a switch 2, a transmission line 3, a transmission line 5 and a load 10, wherein the energy storage device 65 is a pulse forming line, it is characterized in that one end of an energy storage device 65 is connected with an inner conductor 4 at the input end of a transmission line 3 through a switch 2, the other end of the energy storage device 65 is connected with an inner conductor 6 at the input end of the transmission line 5, an outer conductor 7 at the input end of the transmission line 3 is connected with an outer conductor 8 at the input end of the transmission line 5, and is connected with the ground 9, both ends of the load 10 are respectively connected with the inner conductor 11 of the output end of the transmission line 3 and the inner conductor 12 of the output end of the transmission line 5, the outer conductor 13 of the output end of the transmission line 3 is connected with the outer conductor 14 of the output end of the transmission line 5, a unipolar pulse is output across the load 10, but the potentials across the load are of opposite polarity and have an amplitude that is half the voltage V across the energy storage device 65.
Example 13
As shown in fig. 17, a multi-channel multi-polarity steep pulse generation method for tissue ablation comprises an energy storage device 66, a switch 2, a transmission line 3, a transmission line 5 and a load 10, wherein the energy storage device 66 is an artificial line, it is characterized in that one end of an energy storage device 66 is connected with an inner conductor 4 at the input end of a transmission line 3 through a switch 2, the other end of the energy storage device 66 is connected with an inner conductor 6 at the input end of a transmission line 5, an outer conductor 7 at the input end of the transmission line 3 is connected with an outer conductor 8 at the input end of the transmission line 5, and is connected with the ground 9, the two ends of the load 10 are respectively connected with the inner conductor 11 of the output end of the transmission line 3 and the inner conductor 12 of the output end of the transmission line 5, the outer conductor 13 of the output end of the transmission line 3 is connected with the outer conductor 14 of the output end of the transmission line 5, a unipolar pulse is output across the load 10, but the potentials across the load are of opposite polarity and are each half the magnitude of the voltage V across the energy storage device 66.
Example 14
As shown in fig. 18, a multi-channel multi-polarity steep pulse generation method for tissue ablation comprises an energy storage device 1, a switch 2, a switch 67, a transmission line 3, a transmission line 36, a transmission line 37, a transmission line 38, a load 56 and a load 57, wherein the energy storage device 1 is a capacitor, and is characterized in that one end of the energy storage device 1 is connected with an inner conductor 4 at the input end of the transmission line 3 through the switch 2, and the other end of the energy storage device 1 is connected with an inner conductor 43 at the input end of the transmission line 38 through the switch 67; the outer conductor 7 at the input end of the transmission line 3, the outer conductor 40 at the input end of the transmission line 36, the outer conductor 42 at the input end of the transmission line 37 and the outer conductor 44 at the input end of the transmission line 38 are connected together and then are connected with the ground 45; the inner conductor 4 at the input of transmission line 3 is connected to the inner conductor 39 at the input of transmission line 36; the inner conductor 41 at the input end of the transmission line 37 is connected with the inner conductor 43 at the input end of the transmission line 38, the outer conductor 13 at the output end of the transmission line 3, the outer conductor 51 at the output end of the transmission line 36 and the outer conductor 53 at the output end of the transmission line 37 are connected together, the outer conductor 55 at the output end of the transmission line 38 is connected together, two ends of a load 56 are respectively connected with the inner conductor 11 at the output end of the transmission line 3 and the inner conductor 54 at the output end of the transmission line 38, a high-voltage pulse is output on the load 56, and the amplitude is equal to the voltage V on the energy storage device 1; the potentials of the inner conductor 11 at the output end of the transmission line 3 and the potential of the inner conductor 54 at the output end of the transmission line 38 are + V/2 and-V/2 respectively, two ends of a load 57 are connected with the inner conductor 50 at the output end of the transmission line 36 and the inner conductor 52 at the output end of the transmission line 37 respectively, high-voltage pulses are output on the load 57, and the amplitude is equal to the voltage V on the energy storage device 1; compared with the embodiment 6, the potential of the inner conductor 50 at the output end of the transmission line 36 and the potential of the inner conductor 52 at the output end of the transmission line 37 are respectively + V/2 and-V/2, and the potential difference switching circuit is characterized in that the working voltages of the switch 2 and the switch 67 are reduced by half, and the requirement on the insulation strength of two ends of the energy storage device 1 to the ground is reduced by half.
Example 15
As shown in fig. 19, a multi-path multi-polarity steep pulse generation method for tissue ablation comprises an energy storage device 68, a transmission line 3, a transmission line 5 and a load 10, wherein the energy storage device 68 is a Blumlein pulse forming line, it is characterized in that one end of the energy storage device 68 is connected with the inner conductor 4 of the input end of the transmission line 3, the other end of the energy storage device 68 is connected with the inner conductor 6 of the input end of the transmission line 5, the outer conductor 7 of the input end of the transmission line 3 is connected with the outer conductor 8 of the input end of the transmission line 5, and is connected with the ground 9, both ends of the load 10 are respectively connected with the inner conductor 11 of the output end of the transmission line 3 and the inner conductor 12 of the output end of the transmission line 5, the outer conductor 13 of the output end of the transmission line 3 is connected with the outer conductor 14 of the output end of the transmission line 5, a unipolar pulse is output across the load 10, but the potentials across the load are of opposite polarity and are each half the magnitude of the voltage V across the energy storage device 68.
The above-mentioned embodiments are intended to illustrate the objects, technical solutions and advantages of the present invention in further detail, and it should be understood that the above-mentioned embodiments are only exemplary embodiments of the present invention, and are not intended to limit the present invention, and any modifications, equivalents, improvements and the like made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (6)
1. A synchronous multi-path multi-polarity steep pulse generation method for tissue ablation comprises an energy storage device, a switch, a load and a transmission line group, and is characterized in that the transmission line group consists of a plurality of transmission lines which are connected in parallel or in series, the input end of the transmission line group is connected with the energy storage device in series through the switch, each inner conductor at the output end of the transmission line group forms a ground potential with different polarities, each transmission line can independently drive the load, and steep pulses with different polarities are respectively output on different loads; two transmission lines with opposite polarities of inner conductors can be connected in series to drive loads, and synchronous bipolar steep pulses are respectively output on different loads.
2. The transmission line group according to claim 1, wherein: when the number of the transmission line groups is even, the outer conductors at the input ends of the transmission line groups are grounded in parallel; and when the number of the transmission line groups is odd, the outer conductors at the output ends of the transmission line groups are grounded in parallel.
3. The switch of claim 1, wherein: the number of the switches can be single or two, and when the number of the switches is two, two ends of the energy storage device are respectively connected with the input end of the transmission line group through the switches.
4. The switch of claim 1, wherein: including but not limited to spark gap switches, magnetic switches, semiconductor switches, etc.
5. The energy storage device of claim 1, wherein: the energy storage device includes but is not limited to a capacitor, a pulse forming line, an artificial forming line, a pulse generator and the like.
6. The load according to claim 1, wherein: such loads include, but are not limited to, biological tissues, tumors, cells, microorganisms, and the like.
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