CN115006362A - Lamiophlomis rotata pill - Google Patents
Lamiophlomis rotata pill Download PDFInfo
- Publication number
- CN115006362A CN115006362A CN202210668105.9A CN202210668105A CN115006362A CN 115006362 A CN115006362 A CN 115006362A CN 202210668105 A CN202210668105 A CN 202210668105A CN 115006362 A CN115006362 A CN 115006362A
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- CN
- China
- Prior art keywords
- lamiophlomis rotata
- pill
- parts
- pectin
- bismuth
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241001191006 Phlomoides rotata Species 0.000 title claims abstract description 72
- 239000006187 pill Substances 0.000 title claims abstract description 54
- 229910052797 bismuth Inorganic materials 0.000 claims abstract description 28
- JCXGWMGPZLAOME-UHFFFAOYSA-N bismuth atom Chemical compound [Bi] JCXGWMGPZLAOME-UHFFFAOYSA-N 0.000 claims abstract description 28
- 239000010410 layer Substances 0.000 claims abstract description 28
- 229920001277 pectin Polymers 0.000 claims abstract description 28
- 235000010987 pectin Nutrition 0.000 claims abstract description 28
- 239000001814 pectin Substances 0.000 claims abstract description 28
- 229920002472 Starch Polymers 0.000 claims abstract description 17
- 239000002702 enteric coating Substances 0.000 claims abstract description 17
- 238000009505 enteric coating Methods 0.000 claims abstract description 17
- 235000019698 starch Nutrition 0.000 claims abstract description 17
- 239000008107 starch Substances 0.000 claims abstract description 17
- 240000008415 Lactuca sativa Species 0.000 claims abstract description 10
- 235000012045 salad Nutrition 0.000 claims abstract description 10
- 244000068988 Glycine max Species 0.000 claims abstract description 9
- 235000010469 Glycine max Nutrition 0.000 claims abstract description 9
- 239000000796 flavoring agent Substances 0.000 claims abstract description 4
- 235000019634 flavors Nutrition 0.000 claims abstract description 4
- 239000007779 soft material Substances 0.000 claims description 18
- 239000000203 mixture Substances 0.000 claims description 4
- 210000002784 stomach Anatomy 0.000 abstract description 13
- 206010000087 Abdominal pain upper Diseases 0.000 abstract description 8
- 230000000694 effects Effects 0.000 abstract description 7
- 238000010521 absorption reaction Methods 0.000 abstract description 4
- 239000002775 capsule Substances 0.000 abstract description 3
- 210000000936 intestine Anatomy 0.000 abstract description 3
- 239000007787 solid Substances 0.000 description 8
- 210000004051 gastric juice Anatomy 0.000 description 7
- 238000002347 injection Methods 0.000 description 7
- 239000007924 injection Substances 0.000 description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 230000007774 longterm Effects 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 208000002193 Pain Diseases 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000005498 polishing Methods 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 208000006820 Arthralgia Diseases 0.000 description 1
- 229920002261 Corn starch Polymers 0.000 description 1
- 206010017815 Gastric perforation Diseases 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 208000025747 Rheumatic disease Diseases 0.000 description 1
- 206010053476 Traumatic haemorrhage Diseases 0.000 description 1
- 206010000059 abdominal discomfort Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000008120 corn starch Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000000552 rheumatic effect Effects 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 230000008736 traumatic injury Effects 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/245—Bismuth; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The scheme belongs to the field of pharmacy, and particularly relates to a lamiophlomis rotata pill which comprises 50-200 parts of lamiophlomis rotata, 3-10 parts of starch, 3-10 parts of soybean salad oil, 5-50 parts of pectin bismuth and 1-5 parts of enteric coating; the lamiophlomis rotata pill is spherical, and is sequentially provided with a hollow hemispherical lamiophlomis rotata pill, a pectin bismuth layer, an enteric coating layer and a hollow hemispherical lamiophlomis rotata pill from outside to inside. The scheme is provided with the enteric coating layer, so that the ingested lamiophlomis rotata is absorbed in the stomach and the intestine respectively, the absorption amount of the stomach is greatly reduced, and the occurrence of stomachache is reduced. The bismuth pectin has the effect of repairing stomach and can effectively relieve stomachache. In addition, the pectin bismuth is granular, so that the pectin bismuth is very inconvenient to eat, and when the pectin bismuth is arranged in the unique flavor, capsules do not need to be additionally arranged, so that the pectin bismuth is convenient to use. The starch is added, so that the dissolving speed is greatly reduced, the viscosity of the lamiophlomis rotata pills is reduced, and the lamiophlomis rotata pills are more convenient to store and take.
Description
Technical Field
The scheme belongs to the field of pharmacy, and particularly relates to a lamiophlomis rotata pill.
Background
The lamiophlomis rotata is a traditional Chinese medicine of Tibetan, has the functions of promoting blood circulation, stopping bleeding, dispelling wind and relieving pain, and is commonly used for traumatic injury, traumatic bleeding, rheumatic arthralgia and yellow water disease. In the past clinical application, a few patients have stomach discomfort and dull pain after taking the lamiophlomis rotata pills. Particularly, some patients who drink for a long time have long-term alcohol attack, and the stomach has low tolerance capability and even gastric perforation, and the serious problem is more likely to occur when the unique taste needs to be taken. Therefore, there is an urgent need for a lamiophlomis rotata pill for patients who have a long-term drinking of alcohol and have a gastric trouble.
Disclosure of Invention
The scheme provides the lamiophlomis rotata pill which is suitable for patients who drink alcohol for a long time and have stomach trouble to eat.
In order to achieve the purpose, the scheme provides a lamiophlomis rotata pill which comprises 50-200 parts of lamiophlomis rotata, 3-10 parts of starch, 3-10 parts of soybean salad oil, 5-50 parts of pectin bismuth and 1-5 parts of enteric coating according to the mass part ratio; the lamiophlomis rotata pill is spherical, and sequentially comprises a hollow hemispherical lamiophlomis rotata pill, a pectin bismuth layer, an enteric coating layer and a hollow hemispherical lamiophlomis rotata pill from outside to inside.
The principle and the beneficial effect of the scheme are that:
frequent long-term experiments show that one of the important reasons for stomachache caused by the unique taste is that the single intake is too high, so that the stomach absorbs too much unique taste to cause stomachache. The scheme is provided with the enteric coating layer, so that the ingested lamiophlomis rotata is absorbed in the stomach and the intestine respectively, the absorption amount of the stomach is greatly reduced, and the occurrence of stomachache is reduced. The bismuth pectin has the effect of repairing stomach and can effectively relieve stomachache. In addition, the pectin bismuth is granular, so that the pectin bismuth is very inconvenient to eat, and when the pectin bismuth is arranged in the unique flavor, capsules do not need to be additionally arranged, so that the pectin bismuth is convenient to use. The starch is added, so that the dissolving speed is greatly reduced, the viscosity of the lamiophlomis rotata pills is reduced, and the lamiophlomis rotata pills are more convenient to store and take.
Further, the composition comprises 100 parts of lamiophlomis rotata, 8 parts of starch, 8 parts of soybean salad oil, 30 parts of bismuth pectin and 3 parts of enteric coating according to the mass part ratio.
Furthermore, at least one ring of the outmost hollow hemispherical lamiophlomis rotata pill is a soft material layer. The starch can be quickly digested in stomach, and gastric juice can fully enter the lamiophlomis rotata pill, so that the dissolving speed is greatly reduced, and the absorption effect is greatly improved. In addition, the soft flowing layer is mainly starch, is white and is in strong contrast with the color of the lamiophlomis rotata pills. Therefore, if the color of the starch changes, the medicine is affected with damp or loses efficacy, and a good warning effect can be achieved.
Further, the soft material layer is located at the equator. Therefore, the gastric juice can be more uniformly contacted with the interior of the lamiophlomis rotata, and the effect is better.
Drawings
Fig. 1 is a schematic structural diagram of an embodiment of the present invention.
Detailed Description
The following is further detailed by the specific embodiments:
reference numerals in the drawings of the specification include: a hollow hemispherical lamiophlomis rotata pill layer 10, an injection port 11, a soft material layer 12, bismuth pectin 20, an enteric coating 30 and a solid lamiophlomis rotata pill layer 40.
The embodiment is basically as shown in the attached figure 1:
the embodiment provides a lamiophlomis rotata pill which mainly comprises the following raw materials: 100 parts of lamiophlomis rotata, 8 parts of starch, 8 parts of soybean salad oil, 30 parts of bismuth pectin and 3 parts of enteric coating.
The whole shape is spherical, and the hollow hemispherical lamiophlomis rotata pill layer 10, the pectin bismuth layer 20, the enteric coating layer 30 and the hollow hemispherical lamiophlomis rotata pill layer 40 are arranged in sequence from outside to inside. An injection port 11 is arranged on the outermost hollow hemispherical lamiophlomis rotata pill layer 20, and the soft material is filled in the injection port 11. In addition, the equator of the outmost hollow hemispherical lamiophlomis rotata pill 10 is also provided with a soft material layer, actually, two semicircular hollow hemispherical lamiophlomis rotata pills sandwich one soft material layer, and the soft material layer is a mixture of starch and salad oil with equal mass ratio. The starch is corn starch, and the quality of the starch is the same as that of the soybean salad oil.
The preparation method comprises the following steps:
step S10: cutting radix Lamiophlomidis Rotatae, decocting in water for three times, filtering, and mixing filtrates, wherein the water amount added for the first time is 15 times of the mass of radix Lamiophlomidis Rotatae, and the water amount added for the second time and the third time is 12 times of the mass of radix Lamiophlomidis Rotatae;
step S20: heating and concentrating the combined filtrate at-0.06 MPa and 70 deg.C to obtain fluid extract with relative density of 1.1, and heating and concentrating at-0.065 MPa and 60 deg.C to obtain fluid extract with relative density of 1.32;
step S30: placing the extract in a baking pan, setting the height of the extract in the baking pan to be less than 4cm, setting the baking temperature to be below 80 ℃, keeping the vacuum degree to be-0.8 Mpa, and stopping drying until the water content is below 6% to obtain dry extract;
step S40: pulverizing the dry extract, and sieving to obtain extract powder;
step S50: mixing starch, soybean salad oil and the like by mass to obtain a soft material, and then uniformly mixing the soft material and paste powder to obtain an intermediate material;
step S60: adding the intermediate material into a mold to respectively obtain a hollow hemispherical lamiophlomis rotata pill and a solid lamiophlomis rotata pill 40, wherein the diameter of the hollow hemispherical lamiophlomis rotata pill is larger than that of the solid lamiophlomis rotata pill 40;
step S70: coating a layer of enteric coating 30 on the surface of the solid lamiophlomis rotata pill 40;
step S80: putting the solid lamiophlomis rotata pill 40 coated with the enteric coating 30 into the hollow hemispherical lamiophlomis rotata pill, and connecting the solid lamiophlomis rotata pill and the hollow hemispherical lamiophlomis rotata pill together through soft materials to form a sealed lamiophlomis rotata ball;
step S90: injecting pectin bismuth 20 into the lamiophlomis rotata ball through an injection device, and locating outside the solid lamiophlomis rotata pill 40;
step S100: the injection port 11 is filled with soft material.
Step S110: spraying 95% ethanol into the Lamiophlomis rotata pill polishing pot, polishing for 30 min until the surface is flat, smooth and glossy, taking out, and standing at room temperature.
The solid lamiophlomis rotata pill 40 coated with the enteric coating 30 is firstly put into the hollow hemispherical lamiophlomis rotata pill and is connected together through the soft material to form a sealed lamiophlomis rotata ball, so that the lamiophlomis rotata is ensured to be spherical, and the soft material connected in the middle can be digested by gastric juice more quickly, so that the gastric juice can quickly enter the lamiophlomis rotata pill, and the dissolving speed is improved. The bismuth pectin 20 is injected into the lamiophlomis rotata pill by the injector, the integral spherical structure of the lamiophlomis rotata is not damaged, and the operation is convenient. Meanwhile, the injection port 11 left by the injector is filled by the soft material, and the soft material is easier to be digested by gastric juice compared with the lamiophlomis rotata, so that the gastric juice can enter the lamiophlomis rotata along the injection port 11, the release of the gastric juice, the lamiophlomis rotata and the bismuth pectin 20 is further increased, and the dissolving speed is greatly improved.
The scheme is characterized in that the enteric coating is provided with 30 layers, the ingested unique flavor is absorbed in the stomach and the intestine respectively, and the absorption amount of the stomach is greatly reduced, so that the occurrence of stomachache is reduced. The bismuth pectin 20 has the effect of repairing stomach and can effectively relieve stomachache. In addition, the bismuth pectin 20 is granular, so that the bismuth pectin is very inconvenient to eat, and is arranged in the lamiophlomis rotata, so that capsules do not need to be additionally arranged, and the bismuth pectin is convenient to use. The starch is added, so that the dissolving speed is greatly reduced, the viscosity of the lamiophlomis rotata pills is reduced, and the lamiophlomis rotata pills are more convenient to store and take.
The foregoing is merely an example of the present invention and common general knowledge of known specific structures and features of the embodiments is not described herein in any greater detail. It should be noted that, for those skilled in the art, without departing from the structure of the present invention, several changes and modifications can be made, which should also be regarded as the protection scope of the present invention, and these will not affect the effect of the implementation of the present invention and the practicability of the patent. The scope of the claims of the present application shall be determined by the contents of the claims, and the description of the embodiments and the like in the specification shall be used to explain the contents of the claims.
Claims (4)
1. A lamiophlomis rotata pill is characterized in that: according to the mass ratio, the medicinal composition comprises 50-200 parts of lamiophlomis rotata, 3-10 parts of starch, 3-10 parts of soybean salad oil, 5-50 parts of bismuth pectin and 1-5 parts of enteric coating; the lamiophlomis rotata pill is spherical, and sequentially comprises a hollow hemispherical lamiophlomis rotata pill, a pectin bismuth layer, an enteric coating layer and a hollow hemispherical lamiophlomis rotata pill from outside to inside.
2. The lamiophlomis rotata pill of claim 1, wherein: comprises 100 parts of lamiophlomis rotata, 8 parts of starch, 8 parts of soybean salad oil, 30 parts of bismuth pectin and 3 parts of enteric coating according to the mass part ratio.
3. The unique flavor pill of claim 2, wherein: at least one ring of the hollow hemispherical lamiophlomis rotata pills on the outermost layer is a soft material layer, and the soft material layer is a mixture of starch and soybean salad oil.
4. The lamiophlomis rotata pill of claim 3, wherein: the soft material layer is positioned at the equator.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210668105.9A CN115006362A (en) | 2022-06-14 | 2022-06-14 | Lamiophlomis rotata pill |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210668105.9A CN115006362A (en) | 2022-06-14 | 2022-06-14 | Lamiophlomis rotata pill |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN115006362A true CN115006362A (en) | 2022-09-06 |
Family
ID=83075719
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210668105.9A Pending CN115006362A (en) | 2022-06-14 | 2022-06-14 | Lamiophlomis rotata pill |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN115006362A (en) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1562310A (en) * | 2004-04-20 | 2005-01-12 | 成都优他制药有限责任公司 | Soft capsule preparation of Tibet medicine 'unique taste' |
| CN1626207A (en) * | 2004-08-13 | 2005-06-15 | 贵阳云岩西创药物科技开发有限公司 | Preparation including unique ingredient and fabricating method |
| CN110123927A (en) * | 2019-06-21 | 2019-08-16 | 南京致中生物科技有限公司 | A kind of colloidal bismmth pectin complex capsule and preparation method thereof |
| CN110290781A (en) * | 2017-01-26 | 2019-09-27 | 南京三迭纪医药科技有限公司 | The dosage form of stomach and intestine privileged site control release |
| CN111265490A (en) * | 2020-03-16 | 2020-06-12 | 宁夏医科大学 | Lansoprazole enteric-coated pellet and preparation method thereof |
| CN111358830A (en) * | 2020-04-15 | 2020-07-03 | 重庆心康制药有限公司 | Lamiophlomis rotata pill and preparation method thereof |
-
2022
- 2022-06-14 CN CN202210668105.9A patent/CN115006362A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1562310A (en) * | 2004-04-20 | 2005-01-12 | 成都优他制药有限责任公司 | Soft capsule preparation of Tibet medicine 'unique taste' |
| CN1626207A (en) * | 2004-08-13 | 2005-06-15 | 贵阳云岩西创药物科技开发有限公司 | Preparation including unique ingredient and fabricating method |
| CN110290781A (en) * | 2017-01-26 | 2019-09-27 | 南京三迭纪医药科技有限公司 | The dosage form of stomach and intestine privileged site control release |
| CN110123927A (en) * | 2019-06-21 | 2019-08-16 | 南京致中生物科技有限公司 | A kind of colloidal bismmth pectin complex capsule and preparation method thereof |
| CN111265490A (en) * | 2020-03-16 | 2020-06-12 | 宁夏医科大学 | Lansoprazole enteric-coated pellet and preparation method thereof |
| CN111358830A (en) * | 2020-04-15 | 2020-07-03 | 重庆心康制药有限公司 | Lamiophlomis rotata pill and preparation method thereof |
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Application publication date: 20220906 |
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