CN1150014C

CN1150014C - Lupus erythematosus treating medicine

Info

Publication number: CN1150014C
Application number: CNB011044861A
Authority: CN
Inventors: 丁丛礼; 丁赢
Original assignee: Individual
Current assignee: Individual
Priority date: 2001-02-27
Filing date: 2001-02-27
Publication date: 2004-05-19
Anticipated expiration: 2021-02-27
Also published as: CN1310008A

Abstract

The present invention relates to medicine for treating lupus erythematosus caused by accumulated virulent heat-evil and the deficiency of both vital energy and Yin, which is prepared from traditional Chinese medicine, such as red ginseng, american ginseng, red sage root, purple gromwell root, antelope horn, radix glycyrrhiza, white atractylodes rhizome, common anemarrhena rhizome, bear gall, rhubarb, coastal glehnia root, astragalus root, poria coco, rehmannia root, cornel, tree peony bark, water plantain, ledebouriella root, etc. The medicine for treating lupus erythematosus can obviously improve the clinical symptoms and the laboratory inspection index of lupus erythematosus.

Description

A kind of medicine for the treatment of lupus erythematosus

The present invention relates to a kind of medicine for the treatment of lupus erythematosus, is to be the Chinese medicine that feedstock production forms with the Chinese herbal medicine specifically, belongs to the field of Chinese medicines.

Systemic lupus erythematosus (sle) is that world's medical matters circle are referred to as one of four big difficult disease of wrecking the human life, and domestic and international interrelated data report, the sickness rate that every year should disease to be rapidly increasing progressively by a relatively large margin, to the mankind's threat not second to cancer and acquired immune deficiency syndrome (AIDS).In areas such as the Luo Qisite of the U.S., California, the sickness rate in its members of the same clan exceeds hundreds of times of general crowd up to 0.4-5%.Black people's sickness rate is three times in general crowd, and in the Black women of 15-45, per 245 people have a people to suffer from lupus erythematosus, is more common in the 15-25 young women in year especially.Before not using the 17-hydroxy-11-dehydrocorticosterone treatment, the primary disease mortality rate is very high, 80% patient dies from primary disease in 2 years, in recent years because the progress of diagnostic techniques and utilization 17-hydroxy-11-dehydrocorticosterone, the utilization of immunosuppressant, levamisole, antiviral drugs, antilymphocyte globulin thymosin and Chinese herbal medicine, the primary disease mortality rate progressively descends, and best survival rate has reached 80-85% in present 10 years.Though change is arranged, but, still have the part patient to die from organa parenchymatosums such as the heart, kidney, the brain infringement and the complication of primary disease because of various factors, hormone and the immunosuppressant of using both at home and abroad brought potential infection and transition to use this type of medicine to suppress the normal immunologic function of body to patient at present, destroyed organism balance, the patient is caused a disease because of lupus erythematosus, is exactly to cause death because of side effects of pharmaceutical drugs.The medicine that can effectively treat at present lupus erythematosus clinically lacks, and brings very big misery to patient, the patient's of crisis constantly life.

The object of the invention provides a kind of medicine of effective treatment lupus erythematosus.

Medicine of the present invention is that the Chinese herbal medicine by the following weight proportioning forms according to certain prepared:

Radix Ginseng Rubra 3-8

Radix Panacis Quinquefolii 5-15

Radix Astragali 30-40

Poria 20-30

Radix Salviae Miltiorrhizae 15-20

Radix Rehmanniae 18-25

Radix Arnebiae (Radix Lithospermi) 15-20

Cortex Moutan 12-18

Rhizoma Alismatis 12-18

Radix Saposhnikoviae 10-15

Cornu Saigae Tataricae 12-18

Radix Glycyrrhizae Preparata 10-15

Fructus Corni 8-12

Rhizoma Atractylodis Macrocephalae (parched) 10-15

Rhizoma Anemarrhenae 10-15

Fel Ursi 3-8

Radix Et Rhizoma Rhei 15-20

Radix Glehniae 15-20

This medicine of the present invention preferably is prepared from by the Chinese medicine of following weight parts:

Radix Ginseng Rubra 5

Radix Panacis Quinquefolii 10

The Radix Astragali 35

Poria 25

Radix Salviae Miltiorrhizae 18

The Radix Rehmanniae 20

Radix Arnebiae (Radix Lithospermi) 18

Cortex Moutan 15

Rhizoma Alismatis 15

Radix Saposhnikoviae 13

Cornu Saigae Tataricae 15

Radix Glycyrrhizae Preparata 13

Fructus Corni 10

Rhizoma Atractylodis Macrocephalae (parched) 12

The Rhizoma Anemarrhenae 12

Fel Ursi 5

Radix Et Rhizoma Rhei 18

Radix Glehniae 18

In the middle of the above-mentioned raw materials medicine of the present invention, Cornu Saigae Tataricae can replace with Cornu Bubali.

Medicine of the present invention can be prepared into pharmaceutical dosage form commonly used clinically according to common process, and preferred dosage form is a powder.

Medicine of the present invention is according to the Traditional Chinese medical theory prescription, the wherein Radix Rehmanniae, Radix Arnebiae (Radix Lithospermi), Cornu Saigae Tataricae, Radix Et Rhizoma Rhei heat-clearing and toxic substances removing, cool the blood dissipate blood stasis, Radix Glehniae, Radix Ginseng Rubra, the Radix Astragali, Radix Glycyrrhizae Preparata QI invigorating consolidate, Poria, Rhizoma Alismatis, Rhizoma Atractylodis Macrocephalae (parched) spleen invigorating eliminating dampness by diuresis, Radix Salviae Miltiorrhizae, Cortex Moutan, Radix Et Rhizoma Rhei blood circulation promoting and blood stasis dispelling, dredge the meridian passage, Rhizoma Anemarrhenae symphysis ground nourishing YIN and clearing heat, Fructus Corni is mended monk's Liver and kidney, and Radix Saposhnikoviae is dispeled the wind detoxifcation for making.All medicines share, clearing away heat and cooling blood.The detoxifcation dissipating blood stasis, supplementing QI and nourishing YIN, strengthening the body resistance.This compositions is grown and oiliness, and tonify without causing stagnation is broken and do not decrease, and rushes down and does not just hinder, and invigorating middle warmer has rushes down, and residence rushes down in benefit, complement each other, for clear, disappear, live, mend, lead to, extend the agent of closing.

With the medicine of above-mentioned prescription preparation, can obviously improve the clinical symptoms and the laboratory inspection index of lupus erythematosus.Pharmacological evaluation confirms that this compositions can suppress the III allergic reaction type, and spleen plaque forming cells haematolysis ability is improved, and can remove free radical, and inducement interferon increases antiviral ability, and lupus erythematosus is had better therapeutic effect.

Embodiment:

Choose raw material according to following composition

Radix Ginseng Rubra 5 grams

Radix Panacis Quinquefolii 10 grams

The Radix Astragali 35 grams

Poria 25 grams

Radix Salviae Miltiorrhizae 18 grams

The Radix Rehmanniae 20 grams

Radix Arnebiae (Radix Lithospermi) 18 grams

Cortex Moutan 15 grams

Rhizoma Alismatis 15 grams

Radix Saposhnikoviae 13 grams

Cornu Saigae Tataricae 15 grams

Radix Glycyrrhizae Preparata 13 grams

Fructus Corni 10 grams

Rhizoma Atractylodis Macrocephalae (parched) 12 grams

The Rhizoma Anemarrhenae 12 grams

Fel Ursi 5 grams

Radix Et Rhizoma Rhei 18 grams

Radix Glehniae 18 grams

With the Radix Panacis Quinquefolii in the middle of the said medicine, Rhizoma Alismatis, oven dry, be powder with the Cornu Saigae Tataricae pulverize separately, standby, surplus medicinal 4 times of water gagings decoct three times according to common process, filter, get filtrate concentrating, add 2 times of amount 95% ethanol precipitations, left standstill 24 hours, get supernatant concentration to extractum, with above-mentioned each medicine mixing, drying is divided encapsulated then.

Claims

1, a kind of medicine for the treatment of lupus erythematosus is characterized in that this medicine is that Chinese medicine by following weight parts is prepared from: