CN114983862A - Cleaning composition and preparation method and application thereof - Google Patents
Cleaning composition and preparation method and application thereof Download PDFInfo
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- CN114983862A CN114983862A CN202210741410.6A CN202210741410A CN114983862A CN 114983862 A CN114983862 A CN 114983862A CN 202210741410 A CN202210741410 A CN 202210741410A CN 114983862 A CN114983862 A CN 114983862A
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- cleaning composition
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- sodium chloride
- crystal particles
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- 239000000203 mixture Substances 0.000 title claims abstract description 73
- 238000004140 cleaning Methods 0.000 title claims abstract description 47
- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims abstract description 53
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical class O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 39
- 239000002245 particle Substances 0.000 claims abstract description 39
- 239000013078 crystal Substances 0.000 claims abstract description 29
- 239000011780 sodium chloride Substances 0.000 claims abstract description 26
- 229910019142 PO4 Inorganic materials 0.000 claims abstract description 19
- 239000001341 hydroxy propyl starch Substances 0.000 claims abstract description 19
- 235000013828 hydroxypropyl starch Nutrition 0.000 claims abstract description 19
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims abstract description 19
- 239000010452 phosphate Substances 0.000 claims abstract description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 13
- 239000008367 deionised water Substances 0.000 claims abstract description 7
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 7
- 239000003755 preservative agent Substances 0.000 claims abstract description 5
- 229920005862 polyol Polymers 0.000 claims abstract description 3
- 150000003077 polyols Chemical class 0.000 claims abstract description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 18
- 238000003756 stirring Methods 0.000 claims description 15
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims description 9
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 9
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 9
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 9
- 235000019437 butane-1,3-diol Nutrition 0.000 claims description 9
- 230000002209 hydrophobic effect Effects 0.000 claims description 9
- 229960005323 phenoxyethanol Drugs 0.000 claims description 9
- 229940010747 sodium hyaluronate Drugs 0.000 claims description 9
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 9
- 239000000600 sorbitol Substances 0.000 claims description 9
- LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 claims description 5
- 229920002472 Starch Polymers 0.000 claims description 4
- 230000002335 preservative effect Effects 0.000 claims description 4
- 235000019698 starch Nutrition 0.000 claims description 4
- 239000008107 starch Substances 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 3
- 238000012986 modification Methods 0.000 claims description 3
- 230000004048 modification Effects 0.000 claims description 3
- 238000001179 sorption measurement Methods 0.000 claims description 3
- MSRJTTSHWYDFIU-UHFFFAOYSA-N octyltriethoxysilane Chemical compound CCCCCCCC[Si](OCC)(OCC)OCC MSRJTTSHWYDFIU-UHFFFAOYSA-N 0.000 claims description 2
- 239000006254 rheological additive Substances 0.000 claims description 2
- 150000005846 sugar alcohols Polymers 0.000 claims description 2
- NCZPCONIKBICGS-UHFFFAOYSA-N 3-(2-ethylhexoxy)propane-1,2-diol Chemical compound CCCCC(CC)COCC(O)CO NCZPCONIKBICGS-UHFFFAOYSA-N 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000003750 conditioning effect Effects 0.000 claims 1
- 229940100524 ethylhexylglycerin Drugs 0.000 claims 1
- 229960003493 octyltriethoxysilane Drugs 0.000 claims 1
- 239000006260 foam Substances 0.000 abstract description 24
- 239000000126 substance Substances 0.000 abstract description 6
- 230000006378 damage Effects 0.000 abstract description 3
- 208000027418 Wounds and injury Diseases 0.000 abstract 1
- 208000014674 injury Diseases 0.000 abstract 1
- 230000000052 comparative effect Effects 0.000 description 15
- 206010013786 Dry skin Diseases 0.000 description 13
- 230000037336 dry skin Effects 0.000 description 13
- 230000000694 effects Effects 0.000 description 13
- 206010039792 Seborrhoea Diseases 0.000 description 12
- 230000037312 oily skin Effects 0.000 description 12
- 239000000377 silicon dioxide Substances 0.000 description 12
- 239000000047 product Substances 0.000 description 10
- 238000012360 testing method Methods 0.000 description 10
- ANZUDYZHSVGBRF-UHFFFAOYSA-N 3-ethylnonane-1,2,3-triol Chemical compound CCCCCCC(O)(CC)C(O)CO ANZUDYZHSVGBRF-UHFFFAOYSA-N 0.000 description 8
- 239000000523 sample Substances 0.000 description 8
- 238000002474 experimental method Methods 0.000 description 7
- 229920000289 Polyquaternium Polymers 0.000 description 6
- 210000003743 erythrocyte Anatomy 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 206010018910 Haemolysis Diseases 0.000 description 5
- 230000008588 hemolysis Effects 0.000 description 5
- 239000008055 phosphate buffer solution Substances 0.000 description 5
- 239000006228 supernatant Substances 0.000 description 4
- 239000004094 surface-active agent Substances 0.000 description 4
- 239000000725 suspension Substances 0.000 description 4
- 238000004925 denaturation Methods 0.000 description 3
- 230000036425 denaturation Effects 0.000 description 3
- 239000012153 distilled water Substances 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- 238000005187 foaming Methods 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 239000013641 positive control Substances 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 239000012488 sample solution Substances 0.000 description 3
- 229940057950 sodium laureth sulfate Drugs 0.000 description 3
- SXHLENDCVBIJFO-UHFFFAOYSA-M sodium;2-[2-(2-dodecoxyethoxy)ethoxy]ethyl sulfate Chemical compound [Na+].CCCCCCCCCCCCOCCOCCOCCOS([O-])(=O)=O SXHLENDCVBIJFO-UHFFFAOYSA-M 0.000 description 3
- 206010022998 Irritability Diseases 0.000 description 2
- 229920000881 Modified starch Polymers 0.000 description 2
- 239000004368 Modified starch Substances 0.000 description 2
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 2
- 238000002835 absorbance Methods 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 238000007865 diluting Methods 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 235000019426 modified starch Nutrition 0.000 description 2
- 238000012935 Averaging Methods 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 239000002280 amphoteric surfactant Substances 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- IRXRGVFLQOSHOH-UHFFFAOYSA-L dipotassium;oxalate Chemical compound [K+].[K+].[O-]C(=O)C([O-])=O IRXRGVFLQOSHOH-UHFFFAOYSA-L 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 210000001061 forehead Anatomy 0.000 description 1
- 239000008233 hard water Substances 0.000 description 1
- 230000036074 healthy skin Effects 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- -1 nonionic Substances 0.000 description 1
- 238000011056 performance test Methods 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/732—Starch; Amylose; Amylopectin; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/046—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
- A61K8/416—Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/007—Preparations for dry skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/008—Preparations for oily skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a cleaning composition and a preparation method and application thereof, relating to the field of daily chemicals, wherein the cleaning composition comprises the following components: hydroxypropyl starch phosphate, hydrophobically modified silica, amphiphilic sodium chloride crystal particles and deionized water; the preparation method comprises the following steps: (1) adding hydroxypropyl starch phosphate into deionized water to obtain a mixture A; (2) adding the amphiphilic sodium chloride crystal particles into the mixture A to obtain a mixture B; (3) hydrophobically modified silica was added to mixture B to provide the cleaning composition of the present invention. The cleansing bubble is applied to cleansing bubbles and comprises the following components: polyols, preservatives, cleansing compositions and skin conditioners. Compared with the prior art, the product has more foams and is more stable; can effectively clean the skin without causing over-cleaning injury.
Description
Technical Field
The invention relates to the field of daily chemicals, in particular to a cleaning composition and a preparation method and application thereof.
Background
The crystal particles physically adsorb hydrophobic substances on the surfaces of the hydrophilic particles under certain conditions, so that the crystal particles have amphiphilic characteristics. The crystal particles dispersed in the solvent first form a gel structure, and then are aerated with stirring to form a foam, which is different from the foaming mechanism of the conventional surfactant, and the formed foam has an ultra-stable characteristic.
The strong hydrophilicity of the sodium chloride crystal particles causes that the sodium chloride crystal particles can not directly generate foam, and cetyl trimethyl ammonium bromide is embedded on the surfaces of the sodium chloride crystal particles through physical adsorption under certain conditions to prepare the sodium chloride crystal particles with amphipathy, and the sodium chloride crystal particles can be dissolved in water to form foam through stirring, wherein the foam has high stability but is not dense enough.
The natural raw material extract generally has good use safety and environmental friendliness, but has great limitation in application function, the natural raw material is reasonably modified, the modified product not only keeps the original green performance, but also overcomes the defects, and the modified starch is one of the natural raw material extracts. The original starch is treated by physical, chemical or enzymolysis, the structure and physical and chemical properties of the original starch are changed, and the obtained product with changed, strengthened or new properties is called modified starch. The starch can improve the appearance of emulsion, cream and powder, reduce greasy feeling, and give soft and smooth skin feeling, and active ingredients which are not easy to add can be added into the product formula through the encapsulation effect.
Thus, the prior art substances used to form foams are predominantly conventional surfactants, such as anionic, nonionic, amphoteric surfactants. However, although the above system is easy to form foam, the amount of foam formed is small and the stability is poor, and the use of a large amount of surfactant is easy to cause skin irritation, so that a material with a large amount of foam and good stability is urgently needed to be searched for to meet the application development of the industry.
Disclosure of Invention
Aiming at the defects of the prior art, the technical problem to be solved by the invention is to provide a composition with large foam quantity and good stability.
In order to solve the technical problems, the invention adopts the technical scheme that the cleaning composition comprises the following components in parts by mass:
1-2 parts of hydroxypropyl starch phosphate;
0.5-1 part of hydrophobic modified silica;
8-20 parts of amphiphilic sodium chloride crystal particles;
50-80 parts of deionized water;
the particle size of the hydrophobic modified silica is a fixed particle size, and the fixed particle size is preferably 11um and is subjected to hydrophobic modification treatment by triethoxycaprylylsilane.
The amphiphilic sodium chloride crystal particles are embedded on the surfaces of the sodium chloride crystal particles in a physical adsorption mode by adopting hexadecyl trimethyl ammonium bromide and have an amphiphilic cubic structure.
The rheological modifier which is based on the hydroxypropyl starch phosphate and is subjected to pre-gelatinization treatment can be rapidly dispersed in cold water, assists in emulsification stability, increases the appearance and establishes the viscosity, and has the effect of enabling foams to be finer and richer in washing-off products.
Another technical problem to be solved by the present invention is a method for preparing a cleaning composition, comprising the steps of:
(1) adding hydroxypropyl starch phosphate into deionized water at normal temperature, and stirring until the hydroxypropyl starch phosphate is dissolved uniformly to obtain a mixture A;
(2) adding the amphiphilic sodium chloride crystal particles into the mixture A at normal temperature, and uniformly stirring and dissolving to obtain a mixture B;
(3) and adding the hydrophobically modified silica into the mixture B at normal temperature, and stirring to dissolve uniformly to obtain the cleaning composition.
The invention provides a cleansing bubble, which comprises the following components in parts by mass:
3-5 parts of polyol;
0.8-1.1 parts of a preservative;
10-95 parts of a cleaning composition;
0.06-0.6 part of skin conditioner.
The polyalcohol is at least one of sorbitol and 1, 3-butanediol;
the preservative is at least one of phenoxyethanol and ethylhexyl glycerol;
the skin conditioner is at least one of sodium hyaluronate and polyquaternium-7.
Compared with the prior art, the product has more foams, is more exquisite and is more stable; can effectively clean oily skin and simultaneously can not cause excessive cleaning damage to dry skin.
Detailed Description
The following examples and experiments are provided to further illustrate the embodiments of the present invention, but are not intended to limit the present invention.
Example 1
The preparation method of the amphiphilic sodium chloride crystal particles comprises the following steps:
preparing a saturated sodium chloride suspension of hexadecyl trimethyl ammonium bromide with the concentration of 450ppm, continuously stirring for 2h till the solution is completely uniform, heating to boiling at the temperature of 106 +/-2 ℃, and adsorbing hexadecyl trimethyl ammonium bromide on sodium chloride after water is completely evaporated to form crystal particles.
Example 2
The proportion of the cleaning composition is as follows:
the preparation method of the cleaning composition comprises the following steps:
(1) adding hydroxypropyl starch phosphate into deionized water at normal temperature, and stirring until the hydroxypropyl starch phosphate is dissolved uniformly to obtain a mixture A;
(2) adding the amphiphilic sodium chloride crystal particles into the mixture A at normal temperature, and uniformly stirring and dissolving to obtain a mixture B;
(3) and adding the hydrophobically modified silica into the mixture B at normal temperature, and stirring to dissolve uniformly to obtain the cleaning composition.
Example 3
The cleansing bubble comprises the following components in parts by mass:
1 part of sorbitol, 2 parts of 1, 3-butanediol, 55 parts of cleaning composition C, 0.5 part of phenoxyethanol, 0.4 part of ethylhexyl glycerol, 0.01 part of sodium hyaluronate and-70.05 parts of polyquaternium;
the preparation method comprises the following steps: stirring and dispersing sodium hyaluronate 1, 3-butanediol and sorbitol at the normal temperature under 500rpm/min uniformly, adding the cleaning composition, heating to 80 ℃, stirring uniformly under 500rpm/min, cooling to 45 ℃, adding phenoxyethanol, ethylhexyl glycerol and polyquaternium-7 respectively, stirring and dispersing uniformly to obtain a finished product.
Example 4
The cleansing bubble comprises the following components in parts by mass:
2 parts of sorbitol, 3 parts of 1, 3-butanediol, 10 parts of cleaning composition A, 0.1 part of phenoxyethanol, 0.9 part of ethylhexyl glycerol, 0.1 part of sodium hyaluronate and 70.5 parts of polyquaternium;
example 5
The cleansing bubble comprises the following components in parts by mass:
1.5 parts of sorbitol, 2.5 parts of 1, 3-butanediol, 95 parts of cleaning composition B, 1 part of phenoxyethanol, 0.1 part of ethylhexyl glycerol, 0.05 part of sodium hyaluronate and 70.3 parts of polyquaternium;
example 6
The cleansing bubble comprises the following components in parts by mass:
1 part of sorbitol, 3 parts of 1, 3-butanediol, 70 parts of cleaning composition A, 0.5 part of phenoxyethanol, 0.3 part of ethylhexyl glycerol, 0.04 part of sodium hyaluronate and 70.2 parts of polyquaternium;
comparative example 1
A cleansing bubble having the following composition as compared to example 3: no hydrophobically modified silica was added to cleaning composition C.
Comparative example 2
A cleansing bubble having the following composition as compared to example 3: no hydroxypropyl starch phosphate was added to cleaning composition C.
Comparative example 3
A cleansing bubble having the following composition as compared to example 3: sodium laureth sulfate was used instead of the amphiphilic sodium chloride crystal particles in cleaning composition C, with the remaining parameters being the same as in example 3.
Comparative example 4
A cleansing bubble having the following composition as compared to example 3: cleaning composition C had 30um silica instead of 11um silica, with the remaining parameters being the same as in example 3.
Comparative example 4.1
A cleansing bubble having the following composition as compared to example 3: cleaning composition C had 20um silica instead of 11um silica, with the remaining parameters being the same as in example 3.
Comparative example 4.2
A cleansing bubble having the following composition as compared to example 3: cleaning composition C had 25um silica instead of 11um silica, with the remaining parameters being the same as in example 3.
Comparative example 5
A cleansing bubble having the following composition as compared to example 3: cleaning composition C had 8um silica instead of 11um silica, with the remaining parameters being the same as in example 3.
Comparative example 5.1
A cleansing bubble having the following composition as compared to example 3: cleaning composition C had 6um silica instead of 11um silica, with the remaining parameters being the same as in example 3.
Comparative example 5.2
A cleansing bubble having the following composition as compared to example 3: cleaning composition C had 4um of silica instead of 11um of silica, with the remaining parameters being the same as in example 3.
Comparative example 6
The cleansing bubble comprises the following components in parts by mass:
1 part of sorbitol, 2 parts of 1, 3-butanediol, 55 parts of cleaning composition D, 0.5 part of phenoxyethanol, 0.4 part of ethylhexyl glycerol, 0.01 part of sodium hyaluronate and-70.05 parts of polyquaternium;
comparative example 7
The cleansing bubble comprises the following components in parts by mass:
1 part of sorbitol, 2 parts of 1, 3-butanediol, 55 parts of cleaning composition E, 0.5 part of phenoxyethanol, 0.4 part of ethylhexyl glycerol, 0.01 part of sodium hyaluronate and-70.05 parts of polyquaternium;
to better illustrate the benefits of the cleansing composition, cleansing bubbles containing the cleansing composition were taken and subjected to the following efficacy evaluation experiments:
(I) efficacy test:
the lather capacity test, i.e., foam height and foam stability test, was performed on the cleansing bubbles.
Foam properties were determined using the Ross-Miles method: taking 2.5g of the cleansing foam samples provided by application examples 3-6 and application comparative examples 1-5, adding 900mL of distilled water for dissolving, adding 100mL of 1500mg/kg hard water, heating to 40 ℃, taking 200mL of each sample solution to flow down from a pore with the height of 900mm and the inner diameter of 2.9mm, flushing into 50mL of sample solutions with the same temperature and concentration, recording the foam height when the 200mL of sample solution flows out as the foaming capability evaluation index of the sample to be tested, taking the foam height after foaming for 5min as the foam stability evaluation index, testing for three times, calculating the average value of each group after averaging, and keeping the average value to an integer number.
It can be seen from the above examples that the amount of foam increases with increasing amounts of cleaning composition, and that the foam with only amphiphilic sodium chloride crystal particles is too large and not sufficiently dense and not long lasting. The hydrophobically modified silica can stabilize the foam for a longer time and is more delicate, particularly, the effect is best only when the fixed particle size of the hydrophobically modified silica is 11um, and the effect is influenced by the particle size which is too large or too small, which is also a result obtained by accidental discovery and verification in experiments; the addition of hydroxypropyl starch phosphate allows the composition to be protected from over-cleansing for dry skin and effective cleansing for oily skin. And the hydroxypropyl starch phosphate can prevent the over-cleaning effect on dry skin only when being matched with the hydrophobic modified silica and the amphiphilic sodium chloride crystal particles, and has no obvious effect when being matched with the traditional surfactant such as sodium laureth sulfate. Therefore, although the hydroxypropyl starch phosphate has a certain oil absorption capacity and a certain oil and fat cleaning effect, which is common knowledge, the person skilled in the art cannot expect that the hydroxypropyl starch phosphate can protect dry skin under the cleaning effect of the amphiphilic sodium chloride crystal particles, and cannot expect that the hydroxypropyl starch phosphate can be synergistic with the amphiphilic sodium chloride crystal particles to enhance the cleaning effect of the whole composition on oily skin, which is unexpected effect. In particular, the effect is best only when the fixed particle size of the hydrophobically modified silica is 11 μm.
(II) erythrocyte hemolysis safety performance test experiment:
preparation of the erythrocyte suspension: selecting healthy rabbits, taking 9mL of blood from heart, adding 1mL of 2% potassium oxalate solution, centrifuging, discarding supernatant, diluting the precipitate to 20mL with 20mol/L PBS solution, and storing at 4 ℃ for later use. Selected samples were diluted to different concentrations with PBS solution and 5 concentration gradients were set for each sample. Taking 10mL of a dilution of a sample to be tested, adding 200uL of the erythrocyte suspension (controlling the sample concentration to be 5, 10, 20, 50 and 100 mg/mL), taking distilled water as a whole-hemolyzing control, taking a PBS solution as a negative control, mixing the mixture gently, incubating the mixture at 37 ℃ for 30min, centrifuging the mixture at the rotating speed of 2000r/min for 10min, taking a supernatant, testing the absorbance of the supernatant at 560nm by using a spectrophotometer (A560), and calculating the hemolysis rate according to the following formula:
a standard curve of hemolysis rate vs. sample concentration was plotted and the sample concentration at which 50% of the erythrocytes were hemolyzed was calculated (HD 50).
(III) protein denaturation experiment:
diluting a sample to 10g/L by using a PBS (phosphate buffer solution), taking 10mL of a diluent of a sample to be detected, adding 200uL of the erythrocyte suspension, taking distilled water as a blank control, taking a 1mg/mL Sodium Dodecyl Sulfate (SDS) solution as a positive control, gently mixing, incubating for 30min at 37 ℃, centrifuging for 10min at the rotating speed of 2000r/min, taking a supernatant, respectively testing the absorbances A540 and A575 at 540nm and 575nm by using a spectrophotometer, and calculating the protein Denaturation Index (DI) according to the following formula;
wherein R1= blank control group a 575/blank control group a540, R2= experiment group a 575/experiment group a540, R3= positive control group a 575/positive control group a 540. The samples to be tested were evaluated for their irritability according to the L/D value, which is HD50/DI, and the red blood cell hemolysis test irritability rating scale is given in Table 1 below:
the results of the hemolysis test and the protein denaturation test of the above examples are shown in the following table 2:
as can be seen from the table, the L/D value of the product of each embodiment of the invention is more than 100, and the product is safe and non-irritant to human bodies.
(IV) oil clearance test
Selecting 100 volunteers, wherein 50 dry skin subjects (randomly divided into 5 groups and 10 persons in each group) and 50 oily skin subjects (randomly divided into 5 groups and 10 persons in each group), taking the fixed parts of the cheeks and the forehead of the subjects as test areas, measuring the skin oil content of each subject before cleaning the face and the oil content of each subject after cleaning the face by using a CBS (cone beam spot) skin analysis system in an environment at 25 ℃, calculating the oil clearance according to the following formula, and taking the arithmetic mean value of the oil clearance, and inspecting the cleaning effect of the facial cleanser product on the oily skin and the dry skin, wherein the measurement results are as follows:
it is well known that healthy skin needs some oil to be moisturized, and that dry skin needs to remove more of the heavy soils, the less oil removed the better, and that when 19.6% oil clean has been cleaned at a higher level, while oily skin has been removed at 43.5%, the face still feels too oily, and the oil removal is relatively insufficient. Therefore, as can be seen from the above table, when the amphiphilic sodium chloride crystal particles are used alone, the oil removal rate is low for oily skin, and is excessive for dry skin. Example 3, to which the composition of the present invention was added, had moderate oil removal rates for both oily and dry skin, and was suitable for both dry and oily skin. The comparative example 1 without the hydrophobic modified silica and the comparative example 2 without the hydroxypropyl starch phosphate have no ideal effect, and have excessive dry skin oil clearance and insufficient oily skin oil clearance. In addition, in comparative example 3 in which amphiphilic sodium chloride crystal particles were replaced with sodium laureth sulfate, the removal rate of oil from oily skin was inferior to that of example 3, and the removal rate of oil from dry skin was too high, which easily caused phenomena such as tightness and allergy.
Compared with the prior art, the product has more foams, is more exquisite and more stable; can effectively clean oily skin and simultaneously can not cause excessive cleaning damage to dry skin.
The embodiments of the present invention have been described in detail with reference to the examples, but the present invention is not limited to the described embodiments. It will be apparent to those skilled in the art that various changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention.
Claims (9)
1. The cleaning composition is characterized by comprising the following components in parts by mass:
1-2 parts of hydroxypropyl starch phosphate;
0.5-1 part of hydrophobic modified silica;
8-20 parts of amphiphilic sodium chloride crystal particles;
50-80 parts of deionized water;
the particle size of the hydrophobic modified silica is a fixed particle size and is subjected to hydrophobic modification treatment by triethoxyoctylsilane.
2. The cleaning composition of claim 1, wherein the fixed particle size is 11 um.
3. The cleaning composition as claimed in claim 1, wherein the amphiphilic sodium chloride crystal particles are sodium chloride crystal particles embedded on the surfaces of the sodium chloride crystal particles by physical adsorption mode by using hexadecyl trimethyl ammonium bromide and have an amphiphilic cubic structure.
4. The cleaning composition of claim 1, wherein said hydroxypropyl starch phosphate is a starch-based rheology modifier that has been pre-gelatinized.
5. Process for the preparation of a cleaning composition according to claims 1 to 4, characterized in that it comprises the following steps:
(1) adding hydroxypropyl starch phosphate into deionized water at normal temperature, and stirring until the hydroxypropyl starch phosphate is dissolved uniformly to obtain a mixture A;
(2) adding the amphiphilic sodium chloride crystal particles into the mixture A at normal temperature, and uniformly stirring and dissolving to obtain a mixture B;
(3) and adding the hydrophobically modified silica into the mixture B at normal temperature, and stirring to dissolve uniformly to obtain the cleaning composition.
6. A cleansing bubble comprising the cleansing composition of claim 5, comprising the following components in parts by mass:
3-5 parts of polyol;
0.8-1.1 parts of a preservative;
10-95 parts of a cleaning composition;
0.24-0.6 part of skin conditioner.
7. The cleansing bubble of claim 6,
the polyalcohol is at least one of sorbitol and 1, 3-butanediol.
8. The cleansing bubble of claim 6, wherein the preservative is at least one of phenoxyethanol and ethylhexylglycerin.
9. The cleansing bubble of claim 6, wherein the skin conditioning agent is at least one of sodium hyaluronate, polyquaternium-7.
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