CN114980908A - 细胞递送制品和施用方法 - Google Patents
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- CN114980908A CN114980908A CN202180009238.9A CN202180009238A CN114980908A CN 114980908 A CN114980908 A CN 114980908A CN 202180009238 A CN202180009238 A CN 202180009238A CN 114980908 A CN114980908 A CN 114980908A
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Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050063937A1 (en) * | 2003-09-16 | 2005-03-24 | Cheng Li | Multiple-arm peptide compounds, methods of manufacture and use in therapy |
| US20080033429A1 (en) * | 2005-12-14 | 2008-02-07 | Searete Llc | Bone delivery device |
| US20080031921A1 (en) * | 2005-12-14 | 2008-02-07 | Searete Llc | Bone cell delivery device |
| SG160201A1 (en) * | 2000-10-18 | 2010-04-29 | Univ Virginia Commonwealth | Electroprocessing in drug delivery and cell encapsulation |
| CN102596273A (zh) * | 2009-08-28 | 2012-07-18 | 塞诺瓦公司 | 用于细胞移植的方法和设备 |
| CN107073176A (zh) * | 2014-06-09 | 2017-08-18 | 康奈尔大学 | 可植入治疗递送系统及其方法 |
| US20190254959A1 (en) * | 2016-10-20 | 2019-08-22 | Australian Foundation for Diabetes Research | Cell associated scaffolds for delivery of agents |
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| US11565094B2 (en) * | 2017-10-17 | 2023-01-31 | The Methodist Hospital System | Delivery devices |
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- 2021-01-13 MX MX2022008636A patent/MX2022008636A/es unknown
- 2021-01-13 AU AU2021207469A patent/AU2021207469A1/en active Pending
- 2021-01-13 JP JP2022541813A patent/JP2023510257A/ja active Pending
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- 2021-01-13 KR KR1020227027929A patent/KR20220128643A/ko unknown
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Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG160201A1 (en) * | 2000-10-18 | 2010-04-29 | Univ Virginia Commonwealth | Electroprocessing in drug delivery and cell encapsulation |
| US20050063937A1 (en) * | 2003-09-16 | 2005-03-24 | Cheng Li | Multiple-arm peptide compounds, methods of manufacture and use in therapy |
| US20080033429A1 (en) * | 2005-12-14 | 2008-02-07 | Searete Llc | Bone delivery device |
| US20080031921A1 (en) * | 2005-12-14 | 2008-02-07 | Searete Llc | Bone cell delivery device |
| CN102596273A (zh) * | 2009-08-28 | 2012-07-18 | 塞诺瓦公司 | 用于细胞移植的方法和设备 |
| US20190240375A1 (en) * | 2009-08-28 | 2019-08-08 | Sernova Corporation | Methods and devices for cellular transplantation |
| CN107073176A (zh) * | 2014-06-09 | 2017-08-18 | 康奈尔大学 | 可植入治疗递送系统及其方法 |
| US20190254959A1 (en) * | 2016-10-20 | 2019-08-22 | Australian Foundation for Diabetes Research | Cell associated scaffolds for delivery of agents |
Non-Patent Citations (1)
| Title |
|---|
| ALEXANDER U. ERNST等: "Nanotechnology in cell replacement therapies for type 1 diabetes", ADV DRUG DELIV REV., vol. 139, 2 February 2019 (2019-02-02), pages 116 - 138, XP085750633, DOI: 10.1016/j.addr.2019.01.013 * |
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| WO2021146265A1 (en) | 2021-07-22 |
| BR112022013456A2 (pt) | 2022-09-13 |
| EP4090341A1 (en) | 2022-11-23 |
| KR20220128643A (ko) | 2022-09-21 |
| CA3162806A1 (en) | 2022-07-22 |
| AU2021207469A1 (en) | 2022-06-09 |
| US20220409525A1 (en) | 2022-12-29 |
| MX2022008636A (es) | 2022-08-08 |
| JP2023510257A (ja) | 2023-03-13 |
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