CN114948407A

CN114948407A - Temperature-adjustable intracavity cryoablation matched heat preservation device

Info

Publication number: CN114948407A
Application number: CN202111015966.9A
Authority: CN
Inventors: 姜昊文; 徐晨阳; 程长; 陈希南; 陈艺凌
Original assignee: Huashan Hospital of Fudan University
Current assignee: Huashan Hospital of Fudan University
Priority date: 2021-02-22
Filing date: 2021-08-31
Publication date: 2022-08-30
Also published as: CN216294419U

Abstract

The invention belongs to the technical field of medical instruments, and relates to a temperature-adjustable intracavity cryoablation matched heat preservation device which comprises a heating catheter and an air bag, wherein the air bag is arranged in the front end of the heating catheter, one side of the air bag is provided with an opening, the opening is connected with a one-way valve through a pipeline, a plurality of side holes are arranged below the heating catheter, and the tail end of the heating catheter is respectively connected with a heating element and a temperature measuring element; the heating catheter generates heat through internal liquid circulation to keep the temperature of the intestinal wall, liquid reflowing in the heating catheter passes through the temperature measuring element, measured temperature data are transmitted to the heating element, the heating element adjusts the target temperature according to feedback and heats the liquid, and the heated liquid is injected into the heating catheter. When the invention is used in the bladder or ureter cryosurgery, the invention effectively preserves the temperature of the intestinal tract and avoids local low-temperature damage; liquid can be injected into the intestinal cavity while the temperature is kept, so that local injury and discomfort are relieved; the temperature of the reflux liquid is measured, and the reflux liquid can be automatically adjusted according to the local temperature condition of the intestinal cavity.

Description

Temperature-adjustable intracavity cryoablation matched heat preservation device

Technical Field

The invention belongs to the technical field of medical instruments, and particularly relates to a temperature-adjustable intracavity cryoablation matched heat preservation device.

Background

The conventional method for treating the intracavity tumor clinically at present comprises electrode ablation and cryoablation treatment; among them, cryoablation is suitable for various benign and malignant diseases, and since the invention of related freezing technologies at the end of the 19 th century, its clinical application has been widely advocated. However, limited by the equipment and technology, such attempts face two major challenges: firstly, the leakage of a freezing medium in puncture freezing or open surgery causes the visual operation of an operator to be impossible; secondly, the freezing range cannot be precisely controlled, resulting in damage to normal tissues.

With the development of imaging technology, especially the maturation of B-ultrasonic guided percutaneous puncture technology, cryoablation therapy combined with the same is widely used for treating various solid tumors, including liver cancer, kidney cancer, prostate cancer, cervical cancer, and the like. Cryoablation has its unique advantages-firstly, compared with radical tumor resection, cryoablation kills tumors while retaining the basic structure, size and properties of organs, and the focus formed by necrosis can become the basis of tissue fiber scar repair. Secondly, compared with the traditional operation, the operation trauma of the cryoablation operation is relatively small, the operation time is short, the anesthetic dosage is small (even partial operation can adopt local anesthesia), and the bleeding in the operation is also obviously reduced, thereby being beneficial to the postoperative recovery of patients and reducing the economic cost of treatment.

The main principle of cryotherapy is the therapeutic approach of controlled destruction or ablation of living tissue by freezing of local tissue. The tissue is frozen rapidly, the temperature is reduced to below 0 ℃, the tissue fluid inside and outside the cell forms ice crystals, and the cell structure is destroyed. Following cell dehydration, denaturation of the lipoproteins in the membrane system, ischemic infarction of the tissue, nutrient deficiency and eventually necrosis. In the rewarming process, the damaged tissue protein has new antigenic properties, which stimulate the immune system of the body to produce an autoimmune response. Thus, the growth of distant metastases may be inhibited when cryotherapy is applied to a local primary malignancy. The treatment may be carried out by applying the source of refrigeration to the treatment site, or by contacting or penetrating the local tissue with a freezing portion of metal (or balloon). The cryoablation balloon catheter can enable lesion tissues to be damaged more uniformly and thoroughly, improve the long-term success rate and reduce the recurrence. The cryoablation catheter can keep the whole structure of cells complete, limit connective tissues around the cells are not damaged, and the cell surface of an ablation part is relatively smooth and smooth.

With the development of cryoablation, especially urinary tract operations such as bladder and ureter, the adjacent normal tissues of the digestive tract such as rectum may be affected by low temperature, resulting in postoperative intestinal complications such as diarrhea and constipation, and serious ones may cause intestinal obstruction. The existing heat preservation measures in the operation comprise an electric blanket, a warm patch and the like, heat is conducted through the skin, and the local temperature in the intestinal cavity cannot be maintained during the freezing operation.

The existing heat preservation measures in the operation comprise an electric blanket, a warm patch and the like, most of the heat is conducted through the skin, and the local temperature in the intestinal cavity cannot be maintained during the freezing operation. Other patents with the functions of heat preservation and heating in the intestinal cavity, such as an intestinal tract heat preservation pressurizing cleaning device with the patent number of 20191480315, can not realize the function of fixation in the intestinal cavity, and can not ensure that the normal intestinal tract mucous membrane is not damaged when the temperature of a frozen part is higher; meanwhile, in the design, the intestinal canal directly contacts the intestinal mucosa, and the injury is possibly caused in the long-time stay or plugging process, so that the intestinal canal is only suitable for short-time cleaning during medicine injection and does not have the function of continuous heat preservation in the operation. On the other hand, most of the heat preservation devices mainly adopt manual heating, and in the process of repeatedly starting to freeze and recovering to normal temperature in the case of the freezing operation, the temperature of a local area of the operation is changed violently, and the manual heating cannot be changed dynamically according to the temperature, so that the effect of keeping the local temperature constant is achieved.

Based on the current state of the prior art, the applicant of the present invention intends to provide a temperature-adjustable intracavitary cryoablation matched insulation device. The device can keep warm to alimentary tracts such as rectum, colon when the cryoablation operation, reduces the damage that the refrigeration produced the alimentary tract.

Disclosure of Invention

The invention aims to provide a temperature-adjustable intracavity cryoablation matched heat preservation device based on the current situation of the prior art, which is used for keeping the temperature in an intestinal tract during cryosurgery in a bladder or ureter cavity and preventing the freezing injury of the intestinal tract.

The invention provides a temperature-adjustable intracavity cryoablation matched heat preservation device which comprises a heating pipe, a temperature measurement element and a heating element. More specifically, the device comprises a heating pipe 4 and an expansion air bag 1, wherein the heating pipe 4 is of an inner layer structure and an outer layer structure, the inner layer is the expansion air bag 1, the outer layer is a water bag, one side of the expansion air bag 1 is provided with an opening, the opening is connected with a one-way valve 8 through a pipeline, a plurality of side holes 18 are arranged below the heating pipe 4, and the tail end of the heating pipe 4 is respectively connected with a heating element and a temperature measuring element; the heating pipe 4 generates heat through internal liquid circulation to keep the temperature of the intestinal wall, liquid flowing back in the heating pipe 4 passes through the temperature measuring element, measured temperature data are transmitted to the heating element, the heating element adjusts the target temperature according to feedback and heats the liquid, and the heated liquid is injected into the heating pipe 4.

The heating tube is fixed in the intestinal tract during the operation process, the heating element heats the liquid to the target temperature and injects the liquid into the heating tube, the heating tube generates heat through the circulation of the liquid in the heating tube to keep the temperature of the intestinal wall, the refluxed liquid passes through the temperature measuring element, and the measured temperature data is fed back to the heating element. The heating pipe has an inner layer and an outer layer, wherein the inner layer is an expandable air bag, the catheter is fixed in the intestinal tract after expansion, and the outer layer is a water bag for storing heated liquid. The side wall of the catheter is provided with a side hole, and partial liquid flows out through the side hole, so that intestinal mucosa can be lubricated, and the adhesion between the intestinal mucosa and the catheter is avoided. The liquid reflowing in the conduit passes through the temperature measuring element, the measured temperature data is transmitted to the heating element, the heating element adjusts the target temperature according to feedback and heats the liquid, and the heated liquid is injected into the heating pipe.

In the invention, the heating pipe 4 is a soft conduit with the length ranging from 1 cm to 50cm, and the water sac is made of rubber material; the water bag in the heating pipe 4 is connected with the liquid charging pipe 3, and the expansion air bag 1 in the heating pipe 4 is connected with the air charging pipe 2.

In the present invention, the maximum volume of the expandable balloon 1 is 20-50mL, and the length of the expandable balloon is 0.5-3 cm.

In the invention, side holes are arranged below the expandable air bag in the heating pipe in a step shape, each side hole is 1-2mm in size, and liquid in the catheter can flow into an intestinal cavity through the side holes.

In the invention, the temperature measuring element is a temperature sensor 9, the temperature measuring element and the heating element 15 are manufactured and integrated on the liquid storage tank 7, the temperature sensor 9 is fixed on the cover of the liquid storage tank 7, and the heating element 15 is positioned at the inner lower part of the liquid storage tank 7.

In the invention, the heating pipe 4 is fixed on one side of the liquid storage tank 7 through a screw cap 5.

In the present invention, the heating element 15 is connected to the controller 12 through the heater connection wire 11.

In the invention, a one-way valve 8 is arranged on the cover of the liquid storage tank 7, and the inflation tube 2 is connected with the one-way valve 8.

In the invention, the liquid charging pipe 3 is connected with a water outlet 16 of a circulating pump, and the circulating pump 13 is provided with a water inlet 17.

In the invention, the temperature sensor 9 is connected with the controller 12 through the feedback circuit 10, if the temperature is reduced to the set temperature, the temperature is timely fed back to the controller to be heated again.

The temperature-adjustable intracavity cryoablation matched heat preservation device has the beneficial effects that: 1) during the cryosurgery of the bladder or ureter, the intestinal tract is effectively insulated, and the local low-temperature injury is avoided, so that the invention belongs to the originality in the similar inventions; 2) liquid can be injected into the intestinal cavity while the temperature is kept, so that local injury and discomfort are reduced; 3) the temperature of the reflux liquid is measured, and the reflux liquid can be automatically adjusted according to the local temperature condition of the intestinal cavity.

In particular as regards the appearance of the liquid,

the heating pipe of the device has an inner layer and an outer layer, wherein the inner layer is an expandable air bag, the catheter is fixed in the intestinal tract after expansion, and the outer layer is a water bag for storing heated liquid;

the heating pipe is internally provided with an expandable air bag made of rubber materials, the expandable air bag is expanded by injecting gas through a medical injector through a one-way valve, and the one-way valve is positioned on the side surface of the tail end of the catheter. The operation is simple and convenient, and the injury caused by the direct contact of the dilatation balloon with the intestinal mucosa is avoided;

the side wall of the heating pipe is provided with a side hole, and part of liquid flows out through the side hole, so that intestinal mucosa can be lubricated, and the adhesion between the intestinal mucosa and the catheter is avoided;

the liquid reflowing in the heating pipe passes through the temperature measuring element, the measured temperature data is transmitted to the heating element, the heating element adjusts the target temperature according to feedback and heats the liquid, and the heated liquid is injected into the heating pipe. The heat preservation effect of automatic adjustment and constant temperature can be realized.

The device of the invention improves the tolerance of patients in the bladder or ureter cavity cryosurgery, is convenient for the operation development, reduces the postoperative complications and improves the operation safety; the treatment cost of the patient caused by intestinal complications is reduced, the postoperative life quality of the patient is improved, and certain social and economic benefits are achieved; the invention has simple structure, is convenient for batch production, is beneficial to the wider development of the intracavity cryosurgery and benefits the patients.

Drawings

FIG. 1 is a schematic view of the external appearance of a heating pipe of an embodiment 1 of the temperature-adjustable intracavitary cryoablation complete insulation device of the present invention;

FIG. 2 is a schematic view of the internal structure of the temperature-adjustable intracavitary cryoablation complete insulation device of the embodiment 2 of the present invention;

FIG. 3 is a schematic view of the temperature-adjustable intracavity cryoablation kit of the present invention with the upper cover of the reservoir removed in accordance with embodiment 2;

reference numbers in the figures: 1 is an expansion air bag; 2 is an inflation tube; 3 is a liquid filling pipe; 4 is a heating pipe; 5 is a screw cap; 6, a liquid storage tank screw cap; 7 is a liquid storage tank; 8 is a one-way valve; 9 is a temperature sensor; 10 is a feedback circuit; 11 is a heating element connecting wire; 12 is a controller; 13 is a circulating pump; 15 is a heating element; 16 is a water outlet; 17 is a water inlet; and 18 is a side hole.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention will be further described in detail with reference to the accompanying drawings and examples.

The proximal end of the double-balloon cryoablation catheter is close to the operator, and the distal end of the double-balloon cryoablation catheter is far away from the operator.

Example 1

As shown in figure 1, the temperature-adjustable intracavity cryoablation matched heat preservation device comprises a heating pipe 4, a temperature measuring element and a heating element 15. The temperature measuring element adopts a temperature sensor 9, the heating pipe 4 is fixed in the intestinal tract through the internal expansion air bag 1 in the operation process, the heating element heats liquid to a target temperature and injects the liquid into the heating pipe 4, the heating pipe 4 generates heat through internal liquid circulation to keep the temperature of the intestinal wall, the refluxed liquid passes through the temperature measuring element, and the measured temperature data is fed back to the heating element. The heating pipe 4 has an inner layer structure and an outer layer structure, wherein the inner layer is an expansion air bag 1, air is injected through a one-way valve 8, the expansion air bag 1 is expanded to fix the catheter in the intestinal tract, and the outer layer is a water bag which can be used for storing heated liquid. The side wall of the heating pipe 4 is provided with a side hole 18, and part of liquid flows out through the side hole to lubricate intestinal mucosa. The liquid reflowing in the heating pipe 4 passes through the temperature measuring element, the measured temperature data is transmitted to the heating element, the heating element adjusts the target temperature according to feedback and heats the liquid, and the heated liquid is injected into the heating pipe 4.

Example 2

As shown in fig. 2, in the temperature-adjustable intracavitary cryoablation matched heat preservation device, an expandable air bag 1 and a heating pipe 4 are expanded into a whole and are detachably manufactured to be compressed and linked with a liquid storage tank 7 by a screw cap 5; the inflation tube 2 is linked with the one-way valve 8, so that the inflation of the expansion airbag 1 is facilitated by adopting an injector; the liquid filling pipe 3 is connected with a water outlet 16 of a circulating pump 13, and the circulating pump 13 is provided with a water inlet 17 to ensure that constant-temperature liquid circulates in the heating pipe 4 so as to keep a certain temperature for a local freezing part; when liquid (0.9% sodium chloride solution for disinfection and sterilization) needs to be supplemented, the screw cap 6 of the liquid storage tank is unscrewed, the cover is opened, the liquid is injected into the liquid storage tank 7 (the volume is about 2 liters), the liquid level height mark is arranged on the side surface, the liquid level height is observed at any time, and the liquid does not need to be supplemented; the liquid is heated in the reservoir 7 by means of the heating element 15; the heating temperature is controlled by a temperature sensor 9 arranged on the upper part of the liquid storage tank 7, the temperature sensor 9 is connected with a controller 12 through a feedback circuit 10, and if the temperature is reduced to a set temperature (40 +/-2 ℃), the temperature is timely fed back to the controller 12 for reheating; the heating element 15 is connected with the controller 12 through a heater connecting lead 11; the circulating pump 13 is operated all the time in the operation process, the heated liquid is continuously sent to the front end of the heating pipe 4 from the water inlet 17, 3 spirally arranged micropores are about 0.5mm in the interval marked with L of the heating pipe, and a small amount of liquid can flow out, so that the intestinal mucosa is conveniently lubricated; the expansion air bag 1 at the front end of the heating pipe 4 is connected with the inflation pipe 2, the other end of the inflation pipe 2 is connected with the one-way valve 8 on the liquid storage box cover, and the top end of the one-way valve 8 can be used for inflating the expansion air bag 1 by an injector.

Claims

1. The utility model provides a supporting heat preservation device of intracavity cryoablation of adjustable temperature which characterized in that: the heating device comprises a heating pipe (4) and an expansion air bag (1), wherein the heating pipe (4) is of an inner-layer structure and an outer-layer structure, the inner layer is the expansion air bag (1), the outer layer is a water bag, one side of the expansion air bag (1) is opened, the opening is connected with a one-way valve (8) through a pipeline, a plurality of side holes (18) are arranged below the heating pipe (4), and the tail end of the heating pipe (4) is respectively connected with a heating element and a temperature measuring element; the heating pipe (4) generates heat through internal liquid circulation to keep the temperature of the intestinal wall, liquid flowing back in the heating pipe (4) passes through the temperature measuring element, measured temperature data are transmitted to the heating element, the heating element adjusts the target temperature according to feedback and heats the liquid, and the heated liquid is injected into the heating pipe (4).

2. The temperature-adjustable intracavitary cryoablation kit insulation of claim 1, wherein: the heating pipe (4) is a soft conduit with the length range of 1-50cm, and the water sac is made of a rubber material; the water bag in the heating pipe (4) is connected with the liquid charging pipe (3), and the expansion air bag (1) in the heating pipe (4) is connected with the air charging pipe (2).

3. The temperature-adjustable intracavitary cryoablation kit insulation of claim 1, wherein: the maximum volume of the expandable air sac (1) is 20-50mL, and the length diameter of the expandable air sac is 0.5-3 cm.

4. The temperature-adjustable intracavitary cryoablation kit insulation of claim 1, wherein: side holes are arranged below the expandable air bag in the heating pipe (4) in a step shape, the size of each side hole is 1-2mm, and liquid in the heating pipe (4) can flow into an intestinal cavity through the side holes.

5. The temperature-adjustable intracavitary cryoablation kit insulation of claim 1, wherein: the temperature measuring element is a temperature sensor (9), the temperature measuring element and the heating element (15) are integrated on the liquid storage tank (7), the temperature sensor (9) is fixed on the cover of the liquid storage tank (7), and the heating element (15) is positioned at the lower part in the liquid storage tank (7).

6. The temperature-adjustable intracavitary cryoablation kit insulation of claim 1, wherein: the heating pipe (4) is fixed on one side of the liquid storage tank (7) through a screw cap (5).

7. The temperature-adjustable intracavitary cryoablation kit insulation of claim 1, wherein: the heating element (15) is connected with the controller (12) through a heater connecting lead (11).

8. The temperature-adjustable endoluminal cryoablation kit as set forth in claim 1, wherein: a one-way valve (8) is arranged on the cover of the liquid storage tank (7), and the inflation tube (2) is connected with the one-way valve (8).

9. The temperature-adjustable intracavitary cryoablation complete insulation device according to claim 1, wherein: the liquid filling pipe (3) is connected with a water outlet (16) of the circulating pump, and the circulating pump (13) is provided with a water inlet (17).

10. The temperature-adjustable intracavitary cryoablation kit insulation of claim 1, wherein: the temperature sensor (9) is connected with the controller (12) through the feedback circuit (10), and if the temperature is reduced to the set temperature, the temperature is fed back to the controller in time to be heated again.