CN114942264B - Human sweat ion concentration detection device - Google Patents
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- CN114942264B CN114942264B CN202210459308.7A CN202210459308A CN114942264B CN 114942264 B CN114942264 B CN 114942264B CN 202210459308 A CN202210459308 A CN 202210459308A CN 114942264 B CN114942264 B CN 114942264B
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Abstract
The application provides a human sweat ion concentration detection device. When the sweat-promoting gel is used, the stimulating electrode discharges to enable the gel layer to release the penetration-promoting agent, and the penetration-promoting agent can stimulate the human skin to flow sweat after contacting with the human skin, so that the mode of discharging the stimulating electrode to the human body is not needed, and the damage to the human skin is avoided. After sweat passes through the ion-selective membrane, the detection electrode correspondingly generates different detection potentials according to ions with different concentrations. After the ion concentration detection loop calculates the potential difference, the potential difference is sent to the microcontroller, different potential differences correspond to different ion concentration data, and after the microcontroller obtains the potential difference, the corresponding ion concentration data can be obtained according to the potential difference, so that the stimulation and detection of human sweat are realized. The detection electrode, the reference electrode and the stimulation electrode are integrally arranged on the gel layer, so that the structure can be simplified, and the space can be saved.
Description
Technical Field
The application relates to the technical field of wearable equipment, in particular to a human sweat ion concentration detection device.
Background
Wearable sensing technology can continuously monitor the health condition of individuals, and is important to realizing personalized medicine. Electrochemical sensors in combination with wearable sensing technology allow for non-invasive monitoring of analytes in body fluids, thereby dynamically monitoring the physiological health status of an individual, and are well suited for continuous monitoring. The metabolic substances generated in sweat are very rich, the sweat can be collected in a noninvasive way relatively easily when skin pores are excreted, and the biological liquid has great potential in the aspects of health diagnosis, exercise monitoring and the like. Sweat is the most readily available biological fluid in electrochemical sensing applications. Generally, sweat contains metabolites (e.g., lactic acid, glucose, urea, ethanol, or cortisol), electrolytes (e.g., sodium, potassium, chlorine, ammonium), trace elements (e.g., zinc, copper), and small amounts of macromolecules (e.g., proteins, nucleic acids, neuropeptides, or cytokines). Sodium and chlorine are the most common electrolytes in human sweat and are critical for regulation of osmotic pressure. Excessive loss of sodium and potassium in sweat can lead to hyponatremia, hypokalemia, muscle spasms or dehydration. The loss of potassium ions can affect heart beating, and the loss of sodium ions can lead to fatigue and muscle spasm, affecting exercise performance. When people watch Olympic games, NBA and Marathon, athletes often miss the games due to motor cramps and muscle sprains, which are caused by unbalance of sodium ions and potassium ions. The sweat detection effect can be displayed, the electrolyte balance condition of the athlete can be monitored in real time through sweat detection, and early warning is carried out in advance to remind the athlete to supplement electrolyte.
The wearable body surface sweat sensor needs to be attached to the surface of the skin to collect and analyze sweat, and the wearable flexible sensor can better meet the requirements of the non-planar skin. It can be generated in a non-invasive manner and on demand (e.g., by local chemical stimulation) at any location on the human body, well suited for continuous monitoring. The prior wearable body surface sweat sensor needs to discharge to human skin to stimulate the skin to generate sweat, which brings certain pain and damage to the skin surface, and how to detect the ion concentration of the human sweat more safely is a technical problem to be solved in the field.
Disclosure of Invention
In view of this, the present application provides a human sweat ion concentration detection device capable of detecting the ion concentration of human sweat more safely.
In a first aspect, the present application provides a human sweat ion concentration detection device, comprising: a microcontroller configured to generate an analog signal; a current generation module including a pair of stimulation electrodes, the current generation module being electrically connected with the microcontroller, the current generation module configured to: generating a penetration enhancing current according to the analog signal, and outputting the penetration enhancing current from the stimulating electrode; a gel layer doped with a penetration enhancer, the stimulating electrode being applied to a first surface of the gel layer, a second surface of the gel layer opposite to the first surface being for application to human skin; and an ion concentration detection circuit including a detection electrode and a reference electrode, the detection electrode and the reference electrode are connected to the gel layer, the detection electrode is configured to be in contact with sweat flowing out of skin of a human body, an ion selective permeable membrane is attached to the detection electrode, a reference potential of the reference electrode is a preset potential value, the ion concentration detection circuit is electrically connected to the microcontroller, and the ion concentration detection circuit is configured to: and collecting the detection potential of the detection electrode, obtaining a potential difference according to the detection potential and the reference potential, and sending the potential difference to the microcontroller.
When the sweat-promoting gel is used, the stimulating electrode discharges to enable the gel layer to release the penetration-promoting agent, and the penetration-promoting agent can stimulate the human skin to flow out sweat after contacting with the human skin, so that the stimulating electrode does not need to discharge to the human body, and the damage to the human skin is avoided. After sweat passes through the ion-selective membrane, the detection electrode correspondingly generates different detection potentials according to ions with different concentrations. After the ion concentration detection loop calculates the potential difference, the potential difference is sent to the microcontroller, different potential differences correspond to different ion concentration data, and after the microcontroller obtains the potential difference, the corresponding ion concentration data can be obtained according to the potential difference, so that the stimulation and detection of human sweat are realized. The detection electrode, the reference electrode and the stimulation electrode are integrally arranged on the gel layer, so that the structure can be simplified, and the space can be saved.
With reference to the first aspect, in one possible implementation manner, the method further includes: the upper computer is configured to: generating configuration data according to user input, and sending the configuration data to the microcontroller; wherein the microcontroller is further configured to: generating the corresponding analog signals according to the configuration data, and sending the potential differences to the upper computer; and the upper computer obtains corresponding ion concentration data according to the potential difference.
With reference to the first aspect, in one possible implementation manner, the method further includes: and the Bluetooth module is electrically connected with the microcontroller and is configured to be in remote communication with the upper computer.
With reference to the first aspect, in one possible implementation manner, the gel layer has a hollowed-out area, the gel layer has a plurality of small holes, one ends of the small holes are opened on the second surface, and the other ends of the small holes are communicated into the hollowed-out area; the hollowed-out area is used for containing sweat discharged by human skin, and the detection electrode and the reference electrode are both positioned in the hollowed-out area so as to be in contact with the sweat.
With reference to the first aspect, in one possible implementation manner, the microcontroller includes a digital-to-analog converter, and the digital-to-analog converter outputs the analog signal; the current generation module includes: a signal conditioning circuit connected in series with the digital-to-analog converter, the signal conditioning circuit configured to convert the analog signal into a corresponding modulation voltage; a voltage-to-current conversion circuit in series with the signal conditioning circuit, the voltage-to-current conversion circuit configured to convert the modulated voltage to a constant current; and a current protection circuit connected in series with the voltage-to-current conversion circuit, the current protection circuit configured to limit a current value of the constant current within a preset range.
With reference to the first aspect, in one possible implementation manner, the voltage-to-current conversion circuit includes a dual operational amplifier voltage-to-current conversion circuit, and the dual operational amplifier voltage-to-current conversion circuit includes: the first operational amplifier comprises a first in-phase input end, a first reverse phase input end and a first operational amplifier output end, wherein the first reverse phase input end and the first in-phase input end are connected in parallel to the voltage output end of the signal conditioning circuit, and the first operational amplifier output end is connected in series with the current protection circuit; the second operational amplifier comprises a second non-inverting input end, a second inverting input end and a second operational amplifier output end, wherein the second non-inverting input end is connected in series with the first operational amplifier output end, the second inverting input end is connected in series with the first non-inverting input end, and the second operational amplifier output end is connected in series with the first non-inverting input end.
With reference to the first aspect, in one possible implementation manner, the voltage-to-current conversion circuit further includes: direct current negative feedback resistor R s The first inverting input end is connected in series between the voltage output end of the signal conditioning circuit; radio frequency resistor R f Connected in parallel with theThe first inverting input end and the first operational amplifier output end are connected; first resistor R 1 The first non-inverting input end is connected in series between the voltage output end of the signal conditioning circuit and the first non-inverting input end; second resistor R 2 The first operational amplifier is connected in series between the first in-phase input end and the second operational amplifier output end; third resistor R 3 The first operational amplifier output end is connected in series between the first operational amplifier output end and the current protection circuit; load resistor R L Is connected in series with the third resistor R 3 And the current protection circuit.
With reference to the first aspect, in one possible implementation manner, the ion concentration detection circuit further includes: the third operational amplifier comprises a third non-inverting input end, a third inverting input end and a third operational amplifier output end, and the third non-inverting input end is connected with the detection electrode in series; the fourth operational amplifier comprises a fourth non-inverting input end, a fourth inverting input end and a fourth operational amplifier output end, and the fourth inverting input end is connected with the third operational amplifier output end in series; the fifth operational amplifier comprises a fifth non-inverting input end, a fifth inverting input end and a fifth operational amplifier output end, wherein the fifth non-inverting input end is connected with the reference electrode in series, and the fifth operational amplifier output end is connected with the fourth non-inverting input end in series; the sixth operational amplifier comprises a sixth non-inverting input end, a sixth inverting input end and a sixth operational amplifier output end, wherein the sixth non-inverting input end is connected with the fourth operational amplifier output end in series; and a seventh operational amplifier including a seventh in-phase input, a seventh inverting input, and a seventh operational amplifier output, the seventh in-phase input being in series with the sixth operational amplifier output, the seventh operational amplifier output being in series with the microcontroller.
With reference to the first aspect, in one possible implementation manner, the ion concentration detection circuit further includes: eighth resistor R 8 The third inverting input end and the third operational amplifier output end are connected in parallel; fiftieth capacitor R 52 The third inverting input end and the third operational amplifier output end are connected in parallel; tenth resistor R 10 The third operational amplifier output end is connected in series with the fourth inverting input end; seventeenth electricityR resistance 17 The fifth inverting input end and the fifth operational amplifier output end are connected in parallel; sixty-six capacitor C 66 The fifth inverting input end and the fifth operational amplifier output end are connected in parallel; fifteenth resistor R 15 The fifth operational amplifier output end is connected in series with the fourth non-inverting input end; ninth resistor R 9 The second inverting input end is connected with the second operational amplifier output end in parallel; fifty-third capacitor C 53 The second inverting input end is connected with the second operational amplifier output end in parallel; thirteenth resistor R 13 Fourteenth resistor R 14 The fourth operational amplifier output end and the sixth non-inverting input end are sequentially connected in series; fifty-eighth capacitor C 58 The fifty-eighth capacitor C 58 Is connected in series with the thirteenth resistor R 13 And a fourteenth resistor R 14 Between, the fifty-eighth capacitor C 58 The other end of the first inverting input end is connected with the first operational amplifier output end in series; fiftieth capacitor C 55 Connected in parallel with the fifty-eighth capacitor C 58 Is arranged on both ends of (2); eleventh resistor R 11 Twelfth resistor R 12 The third operational amplifier output end is connected in series between the fourth operational amplifier output end and the fourth non-inverting input end in sequence; fiftieth capacitor C 56 The fifty-sixth capacitor C 56 Is connected in series with the eleventh resistor R 11 And a twelfth resistor R 12 Between, the fifty-sixth capacitance C 56 The other end of the first operational amplifier is connected with the first inverting input end of the first operational amplifier in series; fifty-fourth capacitance C 54 Connected in parallel with the fifty-sixth capacitor C 56 Is provided on both ends of (a).
With reference to the first aspect, in one possible implementation manner, the method further includes: and the wearing piece is respectively connected with the microcontroller, the current generation module, the gel layer and the ion concentration detection circuit, and is configured to be worn on a human body.
Drawings
Fig. 1 is a schematic structural diagram of a device for detecting concentration of human sweat ions according to an embodiment of the present application.
Fig. 2 is a schematic diagram of a part of a human sweat ion concentration detection device according to another embodiment of the present application.
Fig. 3 is a schematic circuit diagram of a portion of a human sweat ion concentration detection device according to another embodiment of the present application.
Fig. 4 is a schematic circuit diagram of a portion of a human sweat ion concentration detection device according to another embodiment of the present application.
Detailed Description
The following description of the technical solutions in the embodiments of the present application will be made clearly and completely with reference to the drawings in the embodiments of the present application, and it is apparent that the described embodiments are only some embodiments of the present application, not all embodiments. All other embodiments, which can be made by one of ordinary skill in the art based on the embodiments herein without making any inventive effort, are intended to be within the scope of the present application.
Fig. 1 is a schematic structural diagram of a device for detecting concentration of human sweat ions according to an embodiment of the present application. The application provides a human sweat ion concentration detection device, as shown in fig. 1, comprising a microcontroller 1, a current generation module 2, a gel layer 3 and an ion concentration detection loop 4.
The microcontroller 1 is configured to generate an analog signal. The current generation module 2 comprises a pair of stimulation electrodes 21, the current generation module 2 being electrically connected to the microcontroller 1, the current generation module 2 being configured to: a penetration promoting current is generated from the analog signal and is output from the stimulation electrode 21.
The gel layer 3 is doped with an penetration enhancer, the stimulating electrode 21 is attached to a first surface of the gel layer 3, and a second surface of the gel layer 3 opposite to the first surface is used for being attached to the skin 5 of a human body.
The ion concentration detection circuit 4 includes a detection electrode 41 and a reference electrode 42, the detection electrode 41 and the reference electrode 42 are connected to the gel layer 3, the detection electrode 41 is configured to be in contact with sweat flowing out of the skin 5 of the human body, an ion selective permeable membrane is attached to the detection electrode 41, a reference potential of the reference electrode 42 is a preset potential value, the ion concentration detection circuit 4 is electrically connected to the microcontroller 1, and the ion concentration detection circuit 4 is configured to: the detection potential of the detection electrode 41 is acquired, a potential difference is obtained according to the detection potential 41 and the reference potential 42, and the potential difference is sent to the microcontroller 1.
When the embodiment is used, the stimulating electrode 21 discharges to enable the gel layer 3 to release the permeation enhancer, and the permeation enhancer can stimulate the human skin 5 to flow out sweat after contacting with the human skin 5, so that the stimulating electrode 21 does not need to discharge to the human body, and damage to the human skin 5 is avoided. After passing through the ion-selective permeable membrane, the detection electrode 41 generates different detection potentials according to ions of different concentrations, which is known in the art and is not described herein, and the ion-selective permeable membrane is a Polyimide (PI) substrate. After the ion concentration detection loop 4 calculates the potential difference, the potential difference is sent to the microcontroller 1, different potential differences correspond to different ion concentration data, and after the microcontroller 1 obtains the potential difference, the corresponding ion concentration data can be obtained according to the potential difference, so that the stimulation and detection of human sweat are realized. In addition, the detection electrode 41, the reference electrode 42, and the stimulation electrode 21 are integrally provided on the gel layer 3, so that the structure can be simplified and the space can be saved.
Specifically, the integration plate 100 may be provided on the first surface of the gel layer 3, and the pair of stimulating electrodes 21 described above may be provided on the integration plate 100, thereby further improving the integration, and also preventing the stimulating electrodes 21 from falling off or shifting.
Specifically, the human sweat ion concentration detection device is used for measuring the concentration of Na+ and K+ in sweat. When perspiration begins, the potential difference between the reference electrode 42 and the working electrode is measured. The potential difference stabilized at 20 minutes of current stimulation, indicating that sufficient sweat had been produced. An analog switch may be provided in the microcontroller 1 to terminate the current stimulus when the detected ion concentration reaches a set threshold. The threshold value can be determined according to the conditions of different subjects, and in general, the average value of Na ions in human sweat is 80.4mmol, and the average value of K ions is 12.4mmol. For athletes with a greater amount of perspiration, the corresponding threshold may be raised appropriately.
In one embodiment, as shown in fig. 1, the human sweat ion concentration detection device further includes a host computer 6, where the host computer 6 is configured to: configuration data is generated from user inputs and sent to the microcontroller 1. Wherein the microcontroller 1 is further configured to: and generating the corresponding analog signals according to the configuration data, and transmitting the potential differences to the upper computer 6. The upper computer 6 obtains corresponding ion concentration data according to the potential difference.
In this embodiment, the host computer 6 can generate corresponding analog signals according to user settings, and different analog signals correspond to different permeation promotion currents, so that the size of the permeation promotion currents can be adjusted. In addition, the corresponding relation between the ion concentration data and the potential difference is stored in the upper computer 6 in advance, and the upper computer 6 can calculate the corresponding ion concentration data according to the potential difference, so that the human sweat ion concentration detection device can detect sweat more intelligently.
In an embodiment, the human sweat ion concentration detection device further includes a bluetooth module, and the bluetooth module is electrically connected to the microcontroller 1, and is configured to remotely communicate with the host computer 6. The Bluetooth module can realize remote communication between the upper computer 6 and the microcontroller 1.
Fig. 2 is a schematic diagram of a part of a human sweat ion concentration detection device according to another embodiment of the present application. In an embodiment, as shown in fig. 1 and 2, the gel layer 3 has a hollowed-out area 31, the gel layer 3 has a plurality of small holes 32, one ends of the small holes 32 are opened on the second surface, and the other ends of the small holes 32 are communicated into the hollowed-out area 31. The hollowed-out area 31 is used for containing sweat discharged from the skin 5 of the human body, and the detection electrode 41 and the reference electrode 42 are both positioned in the hollowed-out area 31 to be in contact with the sweat.
When the sweat detection device is used, sweat discharged by the human skin 5 can enter the hollowed-out area 31 through the small holes 32, the sweat entering the hollowed-out area 31 is in contact with the detection electrode 41, and different ion concentrations in the sweat can enable the electric potentials on the detection electrode 41 to be different, so that sweat detection is achieved. Moreover, the hollowed-out area 31 can accommodate sweat obtained by stimulation, and prevent sweat from leaking out.
In an embodiment, the microcontroller 1 comprises a digital-to-analog converter (DAC) that outputs the analog signal. The current generation module 2 comprises a signal conditioning circuit, a voltage-current conversion circuit and a current protection circuit. A signal conditioning circuit is coupled in series with the digital-to-analog converter, the signal conditioning circuit configured to convert the analog signal to a corresponding modulated voltage. A voltage to current conversion circuit is in series with the signal conditioning circuit, the voltage to current conversion circuit configured to convert the modulated voltage to a constant current. The current protection circuit is connected in series with the voltage-current conversion circuit, and is configured to limit the current value of the constant current within a preset range.
In this embodiment, the signal conditioning circuit may use an existing circuit for converting an analog signal into a modulated voltage, the voltage-to-current converting circuit may use an existing current stabilizing circuit, and the current protection circuit may use an existing protection circuit. Generally, the current protection circuit preferably limits the current value of the constant current within the range of less than or equal to 5mA, so that the safety of a wearer can be ensured.
Fig. 3 is a schematic circuit diagram of a portion of a human sweat ion concentration detection device according to another embodiment of the present application. In one embodiment, as shown in fig. 3, the voltage-to-current conversion circuit includes a dual op-amp voltage-to-current conversion circuit, which includes a first operational amplifier 601 and a second operational amplifier 602.
The first operational amplifier 601 includes a first in-phase input end, a first out-phase input end, and a first operational amplifier output end, where the first out-phase input end and the first in-phase input end are connected in parallel to the voltage output end of the signal conditioning circuit, and the first operational amplifier output end is connected in series with the current protection circuit.
The second operational amplifier 602 includes a second non-inverting input terminal, a second inverting input terminal, and a second operational amplifier output terminal, where the second non-inverting input terminal is connected in series with the first operational amplifier output terminal, the second inverting input terminal is connected in series with the first non-inverting input terminal, and the second operational amplifier output terminal is connected in series with the first non-inverting input terminal.
In this embodiment, the voltage output by the signal conditioning circuit is
Is a constant voltage and is replaced by a direct voltage. Suppose an ideal operational amplifierU 1 AndU 2 all operate in the linear region of time,U 1 is +.>
，U 2 The voltages of the same-direction terminal and the opposite-direction terminal are respectively +.>
And->
Then it can be calculated to obtainU 2 The voltage at the same direction terminal is:
namely, the voltage of the output end of the U2 is as follows:
since the voltage at the same direction terminal of U1 is obtained by dividing the voltage at the output terminal of U2, there are:
the inverting terminal voltage of U1 is:
the operational amplifier U1 works in the linear region and meets the condition
The method comprises the following steps:
the method can obtain:
the output current of the circuit thus obtained is:
in circuit design, let
Then the load can be obtained>
Output current +.>
And input voltage->
The relation of (2) is:
I L i.e. the modulation current finally obtained by the voltage-to-current conversion circuit.
In one embodiment, as shown in fig. 3, the voltage-to-current conversion circuit further includes:
direct current negative feedback resistor R s The first inverting input end is connected in series between the voltage output end of the signal conditioning circuit;
radio frequency resistor R f The first inverting input end is connected in parallel with the first operational amplifier output end;
first resistor R 1 The first non-inverting input end is connected in series between the voltage output end of the signal conditioning circuit and the first non-inverting input end;
second resistor R 2 The first operational amplifier is connected in series between the first in-phase input end and the second operational amplifier output end;
third resistor R 3 The first operational amplifier output end is connected in series between the first operational amplifier output end and the current protection circuit; and
load resistor R L Is connected in series with the third resistor R 3 And the current protection circuit.
Fig. 4 is a schematic circuit diagram of a portion of a human sweat ion concentration detection device according to another embodiment of the present application. In one embodiment, as shown in fig. 4, the ion concentration detection circuit 4 further includes:
a third operational amplifier 802 including a third non-inverting input terminal, a third inverting input terminal, and a third operational amplifier output terminal, the third non-inverting input terminal being connected in series with the detection electrode 801;
a fourth operational amplifier 803 including a fourth non-inverting input terminal, a fourth inverting input terminal, and a fourth operational amplifier output terminal, the fourth inverting input terminal being connected in series with the third operational amplifier output terminal;
a fifth operational amplifier 804, including a fifth non-inverting input terminal, a fifth inverting input terminal, and a fifth operational amplifier output terminal, where the fifth non-inverting input terminal is connected in series with the reference electrode 805, and the fifth operational amplifier output terminal is connected in series with the fourth non-inverting input terminal;
a sixth operational amplifier 806, including a sixth non-inverting input terminal, a sixth inverting input terminal, and a sixth operational amplifier output terminal, the sixth non-inverting input terminal being connected in series with the fourth operational amplifier output terminal; and
a seventh operational amplifier 807 comprising a seventh non-inverting input, a seventh inverting input, and a seventh operational amplifier output, said seventh non-inverting input being in series with said sixth operational amplifier output, said seventh operational amplifier output being in series with said microcontroller 1.
In one embodiment, the ion concentration detection circuit 4 further includes:
eighth resistor R 8 The third inverting input end and the third operational amplifier output end are connected in parallel;
fiftieth capacitor R 52 The third inverting input end and the third operational amplifier output end are connected in parallel;
tenth resistor R 10 The third operational amplifier output end is connected in series with the fourth inverting input end;
seventeenth resistor R 17 The fifth inverting input end and the fifth operational amplifier output end are connected in parallel;
sixty-six capacitor C 66 The fifth inverting input end and the fifth operational amplifier output end are connected in parallel;
fifteenth resistor R 15 The fifth operational amplifier output end is connected in series with the fourth non-inverting input end;
ninth resistor R 9 The second inverting input end is connected with the second operational amplifier output end in parallel;
fifty-third capacitor C 53 The second inverting input end is connected with the second operational amplifier output end in parallel;
thirteenth resistor R 13 Fourteenth resistor R 14 The fourth operational amplifier output end and the sixth non-inverting input end are sequentially connected in series;
fifty-eighth capacitor C 58 The fifty-eighth capacitor C 58 Is connected in series with the thirteenth resistor R 13 And a fourteenth resistor R 14 Between, the fifty-eighth capacitor C 58 The other end of the first inverting input end is connected with the first operational amplifier output end in series;
fiftieth capacitor C 55 Connected in parallel with the fifty-eighth capacitor C 58 Is arranged on both ends of (2);
eleventh resistor R 11 Twelfth resistor R 12 The third operational amplifier output end is connected in series between the fourth operational amplifier output end and the fourth non-inverting input end in sequence;
fiftieth capacitor C 56 The fifty-sixth capacitor C 56 Is connected in series with the eleventh resistor R 11 And a twelfth resistor R 12 Between, the fifty-sixth capacitance C 56 The other end of the first operational amplifier is connected with the first inverting input end of the first operational amplifier in series; and
fiftieth capacitor C 54 Connected in parallel with the fifty-sixth capacitor C 56 Is provided on both ends of (a).
As shown in fig. 4, power sources may be connected to the power source interfaces of the third operational amplifier 802, the fourth operational amplifier 803, and the seventh operational amplifier 807.
In an embodiment, the human sweat ion concentration detection device further comprises a wearing piece, wherein the wearing piece is respectively connected with the microcontroller 1, the current generation module 2, the gel layer 3 and the ion concentration detection circuit 4, and the wearing piece is configured to be worn on a human body.
The human sweat ion concentration detection device can be conveniently worn on a human body through the wearing piece, and the wearing piece can be a flexible wearing piece or other wearing structures in various forms.
The basic principles of the present application have been described above in connection with specific embodiments, however, it should be noted that the advantages, benefits, effects, etc. mentioned in the present application are merely examples and not limiting, and these advantages, benefits, effects, etc. are not to be considered as necessarily possessed by the various embodiments of the present application. Furthermore, the specific details disclosed herein are for purposes of illustration and understanding only, and are not intended to be limiting, as the application is not intended to be limited to the details disclosed herein as such.
The block diagrams of the devices, apparatuses, devices, systems referred to in this application are only illustrative examples and are not intended to require or imply that the connections, arrangements, configurations must be made in the manner shown in the block diagrams. As will be appreciated by one of skill in the art, the devices, apparatuses, devices, systems may be connected, arranged, configured in any manner. Words such as "including," "comprising," "having," and the like are words of openness and mean "including but not limited to," and are used interchangeably therewith. The terms "or" and "as used herein refer to and are used interchangeably with the term" and/or "unless the context clearly indicates otherwise. The term "such as" as used herein refers to, and is used interchangeably with, the phrase "such as, but not limited to.
It is also noted that in the apparatus, devices and methods of the present application, the components or steps may be disassembled and/or assembled. Such decomposition and/or recombination should be considered as equivalent to the present application.
The previous description of the disclosed aspects is provided to enable any person skilled in the art to make or use the present application. Various modifications to these aspects will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other aspects without departing from the scope of the application. Thus, the present application is not intended to be limited to the aspects shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
The foregoing description of the preferred embodiments of the present invention is not intended to limit the invention to the precise form disclosed, and any modifications, equivalents, and alternatives falling within the spirit and principles of the present invention are intended to be included within the scope of the present invention.
Claims (8)
1. A human sweat ion concentration detection device, comprising:
a microcontroller configured to generate an analog signal;
a current generation module including a pair of stimulation electrodes, the current generation module being electrically connected with the microcontroller, the current generation module configured to: generating a penetration enhancing current according to the analog signal, and outputting the penetration enhancing current from the stimulating electrode;
a gel layer doped with a penetration enhancer, the stimulating electrode being applied to a first surface of the gel layer, a second surface of the gel layer opposite to the first surface being for application to human skin; and
the ion concentration detection circuit comprises a detection electrode and a reference electrode, wherein the detection electrode and the reference electrode are connected to the gel layer, the detection electrode is configured to be in contact with sweat flowing out of human skin, an ion selective permeable membrane is attached to the detection electrode, the reference potential of the reference electrode is a preset potential value, the ion concentration detection circuit is electrically connected with the microcontroller, and the ion concentration detection circuit is configured to: collecting the detection potential of the detection electrode, obtaining a potential difference according to the detection potential and the reference potential, and sending the potential difference to the microcontroller;
the microcontroller comprises a digital-to-analog converter, and the digital-to-analog converter outputs the analog signal;
the current generation module includes:
a signal conditioning circuit connected in series with the digital-to-analog converter, the signal conditioning circuit configured to convert the analog signal into a corresponding modulation voltage;
a voltage-to-current conversion circuit in series with the signal conditioning circuit, the voltage-to-current conversion circuit configured to convert the modulated voltage to a constant current; and
a current protection circuit connected in series with the voltage-to-current conversion circuit, the current protection circuit configured to limit a current value of the constant current within a preset range;
the ion concentration detection circuit further includes:
the third operational amplifier comprises a third non-inverting input end, a third inverting input end and a third operational amplifier output end, and the third non-inverting input end is connected with the detection electrode in series;
the fourth operational amplifier comprises a fourth non-inverting input end, a fourth inverting input end and a fourth operational amplifier output end, and the fourth inverting input end is connected with the third operational amplifier output end in series;
the fifth operational amplifier comprises a fifth non-inverting input end, a fifth inverting input end and a fifth operational amplifier output end, wherein the fifth non-inverting input end is connected with the reference electrode in series, and the fifth operational amplifier output end is connected with the fourth non-inverting input end in series;
the sixth operational amplifier comprises a sixth non-inverting input end, a sixth inverting input end and a sixth operational amplifier output end, wherein the sixth non-inverting input end is connected with the fourth operational amplifier output end in series; and
the seventh operational amplifier comprises a seventh non-inverting input end, a seventh inverting input end and a seventh operational amplifier output end, wherein the seventh non-inverting input end is connected with the sixth operational amplifier output end in series, and the seventh operational amplifier output end is connected with the microcontroller in series.
2. The human sweat ion concentration detection device of claim 1, further comprising:
the upper computer is configured to: generating configuration data according to user input, and sending the configuration data to the microcontroller;
wherein the microcontroller is further configured to: generating the corresponding analog signals according to the configuration data, and sending the potential differences to the upper computer;
and the upper computer obtains corresponding ion concentration data according to the potential difference.
3. The human sweat ion concentration detection device of claim 2, further comprising:
and the Bluetooth module is electrically connected with the microcontroller and is configured to be in remote communication with the upper computer.
4. The device for detecting the concentration of human sweat ions according to claim 1, wherein,
the gel layer is provided with a hollowed-out area, the gel layer is provided with a plurality of small holes, one ends of the small holes are arranged on the second surface, and the other ends of the small holes are communicated into the hollowed-out area;
the hollowed-out area is used for containing sweat discharged by human skin, and the detection electrode and the reference electrode are both positioned in the hollowed-out area so as to be in contact with the sweat.
5. The human sweat ion concentration detection device of claim 1 wherein the voltage to current conversion circuit comprises a dual op amp voltage to current conversion circuit comprising:
the first operational amplifier comprises a first in-phase input end, a first reverse phase input end and a first operational amplifier output end, wherein the first reverse phase input end and the first in-phase input end are connected in parallel to the voltage output end of the signal conditioning circuit, and the first operational amplifier output end is connected in series with the current protection circuit; and
the second operational amplifier comprises a second non-inverting input end, a second inverting input end and a second operational amplifier output end, wherein the second non-inverting input end is connected in series with the first operational amplifier output end, the second inverting input end is connected in series with the first non-inverting input end, and the second operational amplifier output end is connected in series with the first non-inverting input end.
6. The human sweat ion concentration detection device of claim 5, wherein the voltage-to-current conversion circuit further comprises:
direct current negative feedback resistor R s The first inverting input end is connected in series between the voltage output end of the signal conditioning circuit;
radio frequency resistor R f The first inverting input end is connected in parallel with the first operational amplifier output end;
first resistor R 1 The first non-inverting input end is connected in series between the voltage output end of the signal conditioning circuit and the first non-inverting input end;
second resistor R 2 The first operational amplifier is connected in series between the first in-phase input end and the second operational amplifier output end;
third resistor R 3 The first operational amplifier output end is connected in series between the first operational amplifier output end and the current protection circuit; and
load resistor R L Is connected in series with the third resistor R 3 And the current protection circuit.
7. The human sweat ion concentration detection device of claim 1, wherein the ion concentration detection circuit further comprises:
eighth resistor R 8 The third inverting input end and the third operational amplifier output end are connected in parallel;
fiftieth capacitor R 52 The third inverting input end and the third operational amplifier output end are connected in parallel;
tenth resistor R 10 The third operational amplifier output end is connected in series with the fourth inverting input end;
seventeenth resistor R 17 The fifth inverting input end and the fifth operational amplifier output end are connected in parallel;
sixty-six capacitor C 66 The fifth inverting input end and the fifth operational amplifier output end are connected in parallel;
fifteenth resistor R 15 The fifth operational amplifier output end is connected in series with the fourth non-inverting input end;
ninth resistor R 9 The second inverting input end is connected with the second operational amplifier output end in parallel;
fifty-third capacitor C 53 The second inverting input end is connected with the second operational amplifier output end in parallel;
thirteenth resistor R 13 Fourteenth resistor R 14 The fourth operational amplifier output end and the sixth non-inverting input end are sequentially connected in series;
fifty-eighth capacitor C 58 The fifty-eighth capacitor C 58 Is connected in series with the thirteenth resistor R 13 And a fourteenth resistor R 14 Between, the fifty-eighth capacitor C 58 The other end of the first inverting input is connected in series with the output end of the sixth operational amplifierThe input end is connected with the sixth operational amplifier output end;
fiftieth capacitor C 55 Connected in parallel with the fifty-eighth capacitor C 58 Is arranged on both ends of (2);
eleventh resistor R 11 Twelfth resistor R 12 The third operational amplifier output end is connected in series between the fourth operational amplifier output end and the fourth non-inverting input end in sequence;
fiftieth capacitor C 56 The fifty-sixth capacitor C 56 Is connected in series with the eleventh resistor R 11 And a twelfth resistor R 12 Between, the fifty-sixth capacitance C 56 The other end of the first operational amplifier is connected with the first inverting input end of the first operational amplifier in series; and
fiftieth capacitor C 54 Connected in parallel with the fifty-sixth capacitor C 56 Is provided on both ends of (a).
8. The human sweat ion concentration detection device of claim 1, further comprising:
and the wearing piece is respectively connected with the microcontroller, the current generation module, the gel layer and the ion concentration detection circuit, and is configured to be worn on a human body.
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Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107249471A (en) * | 2015-02-13 | 2017-10-13 | 辛辛那提大学 | The device that integrated indirect sweat is stimulated and sensed |
| CN108024722A (en) * | 2015-07-24 | 2018-05-11 | 辛辛那提大学 | Sample size for the reduction for sensing the analyte produced by Reverse iontophoresis |
| CN109580750A (en) * | 2017-09-28 | 2019-04-05 | 中国科学院苏州纳米技术与纳米仿生研究所 | A kind of wearable perspiration sensor chip, device and the preparation method and application thereof |
| CN110672687A (en) * | 2019-10-29 | 2020-01-10 | 北京科技大学 | Adhesive tape base electrochemical sweat sensor |
| CN111007124A (en) * | 2019-12-04 | 2020-04-14 | 中国科学院电子学研究所 | Sensor for sweat detection and preparation method thereof |
| CN111436945A (en) * | 2020-04-03 | 2020-07-24 | 北京体育大学 | Flexible wearable sweat sensor and sweat analysis method and application thereof |
| CN112255292A (en) * | 2020-10-12 | 2021-01-22 | 浙江工业大学 | Pressurized flexible sweat sensor with secondary collection |
| CN112386289A (en) * | 2020-11-19 | 2021-02-23 | 中国科学院空天信息创新研究院 | Sweat excretion promoting device, sweat collecting system and sweat collecting method |
| CN113662536A (en) * | 2021-08-17 | 2021-11-19 | 海南聚能科技创新研究院有限公司 | Sweat monitoring system |
| CN214844940U (en) * | 2020-12-31 | 2021-11-23 | 中国科学院苏州纳米技术与纳米仿生研究所 | Sweat sensor and sweat sensing system |
-
2022
- 2022-04-27 CN CN202210459308.7A patent/CN114942264B/en active Active
Patent Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107249471A (en) * | 2015-02-13 | 2017-10-13 | 辛辛那提大学 | The device that integrated indirect sweat is stimulated and sensed |
| CN111067544A (en) * | 2015-02-13 | 2020-04-28 | 辛辛那提大学 | Device integrating indirect sweat stimulation and sensing |
| CN108024722A (en) * | 2015-07-24 | 2018-05-11 | 辛辛那提大学 | Sample size for the reduction for sensing the analyte produced by Reverse iontophoresis |
| CN109580750A (en) * | 2017-09-28 | 2019-04-05 | 中国科学院苏州纳米技术与纳米仿生研究所 | A kind of wearable perspiration sensor chip, device and the preparation method and application thereof |
| CN110672687A (en) * | 2019-10-29 | 2020-01-10 | 北京科技大学 | Adhesive tape base electrochemical sweat sensor |
| CN111007124A (en) * | 2019-12-04 | 2020-04-14 | 中国科学院电子学研究所 | Sensor for sweat detection and preparation method thereof |
| CN111436945A (en) * | 2020-04-03 | 2020-07-24 | 北京体育大学 | Flexible wearable sweat sensor and sweat analysis method and application thereof |
| CN112255292A (en) * | 2020-10-12 | 2021-01-22 | 浙江工业大学 | Pressurized flexible sweat sensor with secondary collection |
| CN112386289A (en) * | 2020-11-19 | 2021-02-23 | 中国科学院空天信息创新研究院 | Sweat excretion promoting device, sweat collecting system and sweat collecting method |
| CN214844940U (en) * | 2020-12-31 | 2021-11-23 | 中国科学院苏州纳米技术与纳米仿生研究所 | Sweat sensor and sweat sensing system |
| CN113662536A (en) * | 2021-08-17 | 2021-11-19 | 海南聚能科技创新研究院有限公司 | Sweat monitoring system |
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|---|---|
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