CN112386289A - Sweat excretion promoting device, sweat collecting system and sweat collecting method - Google Patents
Sweat excretion promoting device, sweat collecting system and sweat collecting method Download PDFInfo
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- A—HUMAN NECESSITIES
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- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/0045—Devices for taking samples of body liquids
- A61B10/0064—Devices for taking samples of body liquids for taking sweat or sebum samples
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/42—Detecting, measuring or recording for evaluating the gastrointestinal, the endocrine or the exocrine systems
- A61B5/4261—Evaluating exocrine secretion production
- A61B5/4266—Evaluating exocrine secretion production sweat secretion
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/6802—Sensor mounted on worn items
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
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- Engineering & Computer Science (AREA)
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Abstract
A sweat excretion promoting device, a sweat collecting system and a sweat collecting method are provided, the sweat excretion promoting device comprises a substrate supporting layer, a working electrode and a counter electrode, wherein the working electrode and the counter electrode are arranged on the substrate supporting layer, the counter electrode comprises a conducting layer and a first gel layer which are arranged on the substrate supporting layer from bottom to top in sequence; the working electrode comprises a conducting layer and a second gel layer which are arranged on the substrate supporting layer from bottom to top in sequence. The invention adopts a double-electrode system with double functions of electroosmosis and reverse electroosmosis: the excretion promoting medicine is permeated into the skin through electroosmosis; under the condition of being unfavorable for perspiration, the reverse iontophoresis can be adopted to promote ions, small molecular proteins and the like to be discharged out of the skin; the extraction of various ions, polypeptides and small molecular proteins is realized by the aid of the medicine and low-voltage excretion promotion.
Description
Technical Field
The invention relates to the technical field of sensors, in particular to a sweat excretion promoting device, a sweat collecting system and a sweat collecting method.
Background
Human sweat is rich in a large number of potential health and disease related markers, which have the advantages of non-invasive and real-time continuous monitoring compared with conventional blood and urine detection, so that the research of wearable sweat sensors becomes one of the key points for the development of the field of wearable health electronic devices.
The sweat detection can monitor the electrolyte balance condition of the human body in real time, and early warn to remind the human body of supplementing electrolyte. The loss of potassium ions can affect the heart beating, and the loss of sodium ions can cause fatigue and muscle spasm, and can affect the exercise performance. Calcium is an important component of human metabolism, and the pH value is crucial to the diagnosis of potential diseases; the content of lactic acid can monitor the exercise amount and the metabolism condition of a user, so that the exercise state is adjusted, the training mode becomes more effective, and the lactic acid is one of fatigue marker substances; the body requires the hormonal substance cortisol to maintain normal physiological functions under stress, and without cortisol, the body will not respond effectively to stress. The concentration of ions and lactic acid in sweat is relatively high, the concentration of other small molecule metabolites (hormone, amino acid and polypeptide) is relatively low, the sweat secretion concentration of small molecular weight protein is extremely low, and the concentration of protein in sweat is very low, so that long-time collection and enrichment are needed, and the detection does not realize rapid and timely detection, so that a special permeation promoting and sampling device is needed.
In addition, sedentary healthy individuals are not prone to perspiration, and sweat acquisition and detection is limited by sweat volume requirements and in situ analysis. Designing iontophoresis and permeation-promoting schemes is an excellent solution to overcome this obstacle. The wearable sensor locally stimulates sweat production by iontophoresis, which makes it possible to obtain sweat without requiring exercise, very suitable for sweat collection and detection in sedentary situations and in cool environments. Microcurrent electrodes requiring the application of local electrical current, the hydrogel on these electrodes contains a drug that induces perspiration that is driven by the current to permeate into the skin. And stimulating the nearby sweat glands to secrete sweat, and the sweat can be used for detecting the level of the object to be detected.
Disclosure of Invention
In view of the above, it is a primary objective of the claimed invention to provide a sweat excretion promoting device, a sweat collecting system and a sweat collecting method, so as to at least partially solve at least one of the above technical problems.
To achieve the above objects, as one aspect of the present invention, there is provided a sweat wicking device comprising a substrate support layer and a working electrode and a counter electrode disposed on the substrate support layer, wherein,
the counter electrode comprises a conductive layer and a first gel layer which are arranged on the substrate supporting layer from bottom to top in sequence;
the working electrode comprises a conducting layer and a second gel layer which are arranged on the substrate supporting layer from bottom to top in sequence.
As another aspect of the invention, there is also provided a sweat collection system comprising a sweat wicking device as described above.
As a further aspect of the invention, there is also provided a sweat collection method employing a sweat wicking device as described above or a sweat collection system as described above;
wherein the sweat wicking device has an electroosmotic voltage of 0.2 to 2V.
Based on the above technical solution, the sweat excretion promoting device, the sweat collecting system and the sweat collecting method of the present invention have at least one of the following advantages over the prior art:
1. the invention adopts a double-electrode system with double functions of electroosmosis and reverse electroosmosis: the excretion promoting medicine is permeated into the skin through electroosmosis; under the condition of being unfavorable for perspiration, the reverse iontophoresis can be adopted to promote ions, small molecular proteins and the like to be discharged out of the skin; the extraction of various ions, polypeptides and small molecular proteins is realized by the aid of medicines and low-voltage excretion promotion;
2. the sweat excretion promoting device and the sweat collecting device are applied in a combined manner, and the sweat is collected under negative pressure and stored in a sealing manner;
3. the sweat collection system can be used in conjunction with a wearable flexible sweat detection sensor system.
Drawings
Other objects and advantages of the present invention will become apparent from the following description of the invention which refers to the accompanying drawings, and may assist in a comprehensive understanding of the invention.
FIG. 1 is a schematic diagram of a sweat wicking device in accordance with an embodiment of the invention;
FIG. 2 is a schematic cross-sectional view of a working electrode and a counter electrode according to an embodiment of the present invention;
fig. 3 is a schematic structural view of a sweat negative pressure collection device in an embodiment of the invention.
Description of reference numerals:
1-a working electrode; 2-a counter electrode; 3-a substrate support layer; 4-a conductive layer; 5-a first gel layer; 6-a second gel layer; 7-a fixation unit; 8-reserving holes; 9-a collector; 10-negative pressure balloon; 11-sealing cover.
Detailed Description
Hereinafter, the present invention will be described in detail with reference to the accompanying drawings and examples to assist those skilled in the art in fully understanding the objects, features and effects of the present invention. Exemplary embodiments of the present invention are illustrated in the drawings, but it should be understood that the present invention can be embodied in other various forms and should not be limited to the embodiments set forth herein. Moreover, in the following description, descriptions of well-known structures and techniques are omitted so as to not unnecessarily obscure the concepts of the present invention. In addition, the embodiments of the present invention provided below and the technical features in the embodiments may be combined with each other in an arbitrary manner.
The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. Furthermore, the terms "comprises," "comprising," "includes," "including," "has," "having," and the like, when used herein, specify the presence of stated features, steps, operations, and/or components, but do not preclude the presence or addition of one or more other features, steps, operations, or components. All terms (including technical and scientific terms) used herein have the same meaning as commonly understood by one of ordinary skill in the art unless otherwise defined. It is noted that the terms used herein should be interpreted as having a meaning that is consistent with the context of this specification and should not be interpreted in an idealized or overly formal sense.
The invention discloses a sweat excretion promoting device, which comprises a substrate supporting layer, a working electrode and a counter electrode, wherein the working electrode and the counter electrode are arranged on the substrate supporting layer,
the counter electrode comprises a conductive layer and a first gel layer which are arranged on the substrate supporting layer from bottom to top in sequence;
the working electrode comprises a conducting layer and a second gel layer which are arranged on the substrate supporting layer from bottom to top in sequence.
In some embodiments of the present invention, the material of the first gel layer includes at least one of polyvinyl alcohol hydrogel and polyethylene oxide hydrogel;
in some embodiments of the present invention, the second gel layer material includes an ionotropic agent therein and further includes at least one of a polyvinyl alcohol hydrogel and a polyethylene oxide hydrogel.
In some embodiments of the invention, the working electrode and the counter electrode are disposable electrodes.
In some embodiments of the invention, the shape of the working electrode comprises a circle or a square;
in some embodiments of the invention, the shape of the counter electrode comprises a circle or a square.
In some embodiments of the invention, the sweat wicking device further comprises a securement unit;
in some embodiments of the invention, the fixing unit is in the form of a band.
In some embodiments of the invention, the sweat excretion device further comprises an excretion circuit unit;
in some embodiments of the invention, the working electrode and the counter electrode are both connected to the firing line unit.
The invention also discloses a sweat collection system comprising a sweat excretion facilitating device as described above.
In some embodiments of the invention, a negative pressure sweat collection and preservation device is also included;
in some embodiments of the invention, the negative pressure sweat collection and preservation device comprises a collector, a negative pressure balloon, and a cover;
in some embodiments of the invention, the negative pressure balloon is connected to the collector by a sealing tube.
The invention also discloses a sweat collection method, which adopts the sweat excretion promoting device or the sweat collection system.
In some embodiments of the invention, the sweat wicking device has an electroosmotic voltage of 0.2 to 2V. For example, 0.2V, 0.5V, 0.8V, 1V, 1.5V, 2V.
In some embodiments of the invention, the sweat wicking device has a penetration time of 1 to 20 minutes, such as 1 minute, 5 minutes, 8 minutes, 10 minutes, 12 minutes, 15 minutes, 20 minutes.
The technical solution of the present invention is further illustrated by the following specific embodiments in conjunction with the accompanying drawings. It should be noted that the following specific examples are given by way of illustration only and the scope of the present invention is not limited thereto.
The invention provides a sweat collection system consisting of a sweat discharge promoting device and a negative pressure sweat storage device which are made of multilayer materials, which can be used for promoting discharge, collecting and storing skin sweat and provides data guidance and reference for observing human body signs, states and functions.
The sweat excretion promoting device and the negative pressure sweat storing device can be used in a matched mode or applied independently, and the device is simple and convenient to operate and easy to store and carry.
The electroosmosis effect through the sweat promotes and removes the device can realize the sustained release of skin ion to can cooperate negative pressure sweat save set to effectively collect, reduce sweat and volatilize, sealed save the back, the contrast of the multiple instrument of the later stage of being convenient for is detected. The method provides support for high-precision detection of various substances such as protein and ions in sweat, and is beneficial to integral judgment of human body information. Has wide application prospect in the aspects of detection of special diseases, health monitoring of chronic patients and the like.
Sweat excretion promoting device
As shown in fig. 1-2, the sweat excretion facilitating device is composed of a disposable electrode, a low voltage excretion facilitating circuit unit, and a fixing unit 8. The disposable electrode comprises a counter electrode 1 and a working electrode 2, the counter electrode 1 and the working electrode 2 are arranged on a substrate supporting layer 3, and the counter electrode 1 comprises an electrode layer 4 and a first gel layer 5; an electrode layer 4 and a second gel layer 6 included on the working electrode 2.
The counter electrode 1 and the working electrode 2 can adopt disposable electrodes, so that the possible cross contamination caused by multiple use is avoided. The electrode substrate may be a plastic substrate or a paper substrate. The preparation of the electrode is carried out by adopting Micro-Electro-Mechanical systems (MEMS) technology metal evaporation, photoetching or printing technology, and comprises a working electrode and a counter/reference electrode.
Wherein, the first gel layer 5 is a common gel layer, and the second gel layer 6 is an electro-osmotic gel layer. The gel material of the first gel layer 5 can be selected from hydrogel, macromolecule cross-linked conductive gel and the like. Specifically, the material used for the first gel layer 5 may be Polyvinyl alcohol (PVA) hydrogel, polyethylene oxide (PEO) hydrogel or mixed hydrogel.
The second gel layer 6 of the working electrode 1 is formed by adding an ion excretion promoter such as pilocarpine into the first gel layer 5, wherein the addition amount is less than 0.1% w/w, so as to achieve the exudation and collection of human sweat in a non-exercise state. The trace of the expulsion promoter is introduced into the skin epidermis through the pores on the skin by low voltage electroosmosis on the electroosmotic electrode (i.e., the working electrode 1), which then ceases electroosmosis.
The first gel layer 5 and the second gel layer 6 can be pre-fixed to the electrodes or can be prepared as disposable patches of the size of the electrodes to be applied to the electrode surface before use.
The sweat excretion promoting device is mainly divided into two parts, namely the production of an excretion promoting electrode array and an excretion promoting circuit unit. The preparation of the row-promoting electrode array mainly comprises three parts of electrode array manufacturing, row-promoting gel layer preparation and packaging. Firstly, manufacturing an electrode array, selecting a disposable electrode because cross infection is avoided, adopting a screen printing electrode and conducting carbon paste to print the electrode in order to reduce cost, selecting domestic high-quality high-conducting carbon paste as a lead and the electrode to print and prepare the electrode on a plastic substrate in small batches, simulating the shape and size of the electrode to optimize, drawing and shaping, and baking and drying the carbon paste electrode for later use after printing; then fixing and modifying the excretion-promoting gel layer, adopting polyvinyl alcohol hydrosol or polyethylene oxide (PEO) hydrogel as a modifying layer to be fixed on the electrode, and adding 0.05-0.2% w/w of excretion-promoting agents such as pilocarpine and the like in the preparation process of the hydrogel to stimulate the sweat glands of the skin to secrete ions. And (4) drying the modified electrode, and independently sealing for later use.
The electroosmosis circuit in the discharge promoting circuit unit adopts a laboratory self-made conventional circuit board, and the electroosmosis control program comprises the following steps: controlling the electroosmosis voltage to be between 0.2 and 2V; the permeation promoting time is controlled to be 1-20 minutes.
(II) negative pressure sweat preservation device
As shown in fig. 3, the negative pressure sweat containment device includes a collector 9, a negative pressure balloon 10, and a cover 11. After the collector 9 is fixed on the arm, low negative pressure treatment is carried out through the negative pressure balloon 10, sweat collection and collector 9 fixation are facilitated, collection is carried out for 10-60 minutes, the sealing cover 11 of the collector 9 is sealed, and the collector is refrigerated and placed.
The collector 9 and the matched sealing cover 11 are prepared by a one-step forming method. The negative pressure saccule 10 and the sealing tube matched and connected with the negative pressure saccule are fixedly connected on the reserved hole 8 of the collector 9 through adhesive. Before collector 9 placed, the compression sacculus, collector 9 placed fixed back, and the sacculus is released, forms the negative pressure between collection box and skin, both had both been favorable to the sweat to discharge and collect, also prevented volatilizing of sweat.
Sterile gauze or an absorption unit adopting a spiral tube can be placed in the collector 9, so that sweat can be absorbed conveniently, but the gauze can adsorb protein or polypeptide molecules in the sweat and then is difficult to separate, so that the collector can only be used for collecting and detecting sweat ions, and the collection box for protein detection is not provided with gauze or filter paper and the like with adsorption.
It should be noted that, although the invention has been shown and described with reference to the specific exemplary embodiments thereof, it should be understood by those skilled in the art that the present invention is not limited to the above-mentioned embodiments, and various changes and modifications may be made therein without departing from the spirit and scope of the invention, and it is intended that the invention encompass such changes and modifications as fall within the scope of the claims and the equivalent technical scope of the invention.
In particular, various combinations and/or combinations of features recited in the various embodiments and/or claims of the present invention can be made without departing from the spirit and teachings of the invention, even if such combinations or combinations are not explicitly recited in the present invention. All such combinations and/or associations are within the scope of the present invention. The scope of the invention should, therefore, be determined not with reference to the appended claims, but should instead be determined with reference to the following claims.
Claims (10)
1. A sweat wicking device comprising a substrate support layer and a working electrode and a counter electrode disposed on the substrate support layer, wherein,
the counter electrode comprises a conductive layer and a first gel layer which are arranged on the substrate supporting layer from bottom to top in sequence;
the working electrode comprises a conducting layer and a second gel layer which are arranged on the substrate supporting layer from bottom to top in sequence.
2. The sweat wicking device of claim 1,
the first gel layer is made of at least one of polyvinyl alcohol hydrogel and polyethylene oxide hydrogel;
the second gel layer material comprises an ionic expulsion promoter and at least one of polyvinyl alcohol hydrogel and polyethylene oxide hydrogel.
3. The sweat wicking device of claim 1,
the working electrode and the counter electrode are disposable electrodes.
4. The sweat wicking device of claim 1,
the shape of the working electrode comprises a circle or a square;
the shape of the counter electrode includes a circle or a square.
5. The sweat wicking device of claim 1,
the sweat excretion promoting device also comprises a fixing unit;
the fixing unit is in a watchband shape.
6. The sweat wicking device of claim 1,
the sweat excretion promoting device also comprises an excretion promoting circuit unit;
the working electrode and the counter electrode are connected with the row promoting circuit unit.
7. A sweat collection system comprising a sweat wicking device according to any one of claims 1 to 6.
8. A sweat collection system according to claim 7, wherein,
the device also comprises a negative pressure sweat collecting and storing device;
wherein the negative pressure sweat collecting and storing device comprises a collector, a negative pressure balloon and a sealing cover;
the negative pressure sacculus is connected with the collector through a sealing tube.
9. A sweat collection method employing a sweat wicking device according to any one of claims 1 to 6 or a sweat collection system according to claim 7 or 8;
wherein the sweat wicking device has an electroosmotic voltage of 0.2 to 2V.
10. A sweat collection method according to claim 9, wherein,
the sweat excretion promoting device has an infiltration promoting time of 1 to 20 minutes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011304958.1A CN112386289A (en) | 2020-11-19 | 2020-11-19 | Sweat excretion promoting device, sweat collecting system and sweat collecting method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011304958.1A CN112386289A (en) | 2020-11-19 | 2020-11-19 | Sweat excretion promoting device, sweat collecting system and sweat collecting method |
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| CN112386289A true CN112386289A (en) | 2021-02-23 |
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| CN202011304958.1A Pending CN112386289A (en) | 2020-11-19 | 2020-11-19 | Sweat excretion promoting device, sweat collecting system and sweat collecting method |
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| CN113577528A (en) * | 2021-08-26 | 2021-11-02 | 中国科学院深圳先进技术研究院 | Piezoelectric electret drug delivery patch for transdermal drug delivery by combining contact pressure or beating and preparation method and application thereof |
| CN114287974A (en) * | 2021-12-30 | 2022-04-08 | 南京子麒舜生物科技有限公司 | Two-in-one sweat-accelerating instrument and sweat-extracting plate structure |
| CN114942264A (en) * | 2022-04-27 | 2022-08-26 | 中国科学院空天信息创新研究院 | Human body sweat ion concentration detection device |
| EP4074263A1 (en) * | 2021-04-14 | 2022-10-19 | Anke Görgner | Aspirate for use in diagnosis |
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Application publication date: 20210223 |