CN114939241A - 3D printing source application die body block entering narrow lacuna recombination fixing technology in brachytherapy - Google Patents
3D printing source application die body block entering narrow lacuna recombination fixing technology in brachytherapy Download PDFInfo
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- CN114939241A CN114939241A CN202210619763.9A CN202210619763A CN114939241A CN 114939241 A CN114939241 A CN 114939241A CN 202210619763 A CN202210619763 A CN 202210619763A CN 114939241 A CN114939241 A CN 114939241A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N5/1002—Intraluminal radiation therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N5/1007—Arrangements or means for the introduction of sources into the body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N5/1014—Intracavitary radiation therapy
- A61N5/1016—Gynaecological radiation therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/103—Treatment planning systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/103—Treatment planning systems
- A61N5/1039—Treatment planning systems using functional images, e.g. PET or MRI
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y80/00—Products made by additive manufacturing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N5/1007—Arrangements or means for the introduction of sources into the body
- A61N2005/1008—Apparatus for temporary insertion of sources, e.g. afterloaders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N2005/1019—Sources therefor
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N2005/1092—Details
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- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Manufacturing & Machinery (AREA)
- Materials Engineering (AREA)
- Radiation-Therapy Devices (AREA)
Abstract
A3D prints the die body of the source application and divides the block to enter the fixed technology of regrouping after the narrow lacuna in the brachytherapy, cut the die body plane of the source application and divide the block first, utilize 3D printer to print out the die body block of the entity source application, pass the die body of the source application of the block through the narrow lacuna and reach the fixed technology of regrouping after the assigned position sequentially, the die body of the source application after the block can be smooth to pass the narrow lacuna that the die body of the whole source application is difficult to pass through; the block-type source application die body comprises a source application channel capable of placing an inserting needle, a source applicator or a particle implantation needle, the tail end of the source application channel is provided with length marking compensation, the depth of the inserting needle can be compensated to be an integer, and the length marking compensation is compared with the scales of the inserting needle, the source applicator or the particle implantation needle, so that the operation of a doctor in the actual treatment is facilitated.
Description
Technical Field
The invention relates to the field of brachytherapy, in particular to 3D printing.
Background
Cervical cancer refers to malignant tumors occurring in the uterine vagina and cervical canal, is one of common malignant tumors of women, has the second place of female tumor, and accounts for 73-93% of the malignant tumors of female reproductive systems. In the treatment of cervical cancer, NCCN guidelines indicate advanced cases in stage IIB and beyond, usually without surgery, most using chemoradiotherapy. Brachytherapy is a key part of radical radiotherapy, and can be used for patients who cannot be treated by intracavity brachytherapy or patients who are unsatisfied by intracavity brachytherapy by inserting tissues. However, the danger that the inserting needle penetrates into normal tissues in a way of miss-target insertion exists in the process of bare-handed insertion, the current 3D printing combined back-loading close-range insertion radiotherapy becomes the current popular research direction, the needle inserting direction, position and depth can be designed in advance due to the whole-course visual operation of the 3D printing, and obvious dosimetry advantages and safety guarantee are shown.
In the method, a source application die body placed in the vagina is used for carrying out brachytherapy, and the source application die body comprises a uterine cavity tube channel, an insertion needle channel with fixed direction and insertion needle depth and a protrusion for connecting and fixing a die for fixing the source application die body to reduce the rotation error of the source application die body (patent number: 202111196657.6).
However, due to anatomical differences of the vagina of some patients or vaginal stenosis caused by long-distance irradiation, the manufactured donor die body is large in two ends and thin in the center, and cannot reach a designated position through a narrow part easily; and the end of the application source die body is a plane, so that the measured needle insertion length is not an integer mostly, and the insertion needles are segmented at intervals of 1cm mostly, although a Mark pen or a thin rubber band can be used for measuring and marking the needle insertion length, the treatment efficiency is reduced in the actual treatment.
Disclosure of Invention
In order to overcome the defects of the prior art, the invention provides a 3D printing source applying die body recombination and fixation technology after the source applying die body enters a narrow lacuna in a partitioning manner, wherein the manufactured source applying die body is divided into a plurality of blocks, and the blocks enter the vagina in multiple times to reach designated positions and are fixed; and length marking compensation is added at the tail end of the source application die body, so that the needle insertion length is an integer, and the operation of a doctor is facilitated.
The technical scheme adopted by the invention is as follows: in the die body manufacturing stage, performing plane cutting on the source die body model file, wherein the number of cutting blocks is more than 3; in the cutting process, the cutting plane is parallel to the uterine cavity tube and the insertion needle channel as much as possible so as to avoid cutting off the source application channel; the sharp edges and edges after cutting are required to be smoothed, so that pain or vaginal injury of a patient caused by placing a source applying die body is prevented; extending the tail end of the model file of the source application die body out of the vagina by 2-3 cm, carving a groove at a proper position of the extended part, tightening and fixing the groove by using a binding belt after entering the vagina, and preventing the source application die body from moving when an inserting needle is placed; the length compensation block is added at the tail end of the model file, so that the needle insertion length of the insertion needle is an integer and can be compared with 1cm subsection scales of the insertion needle, and the operation of a doctor in actual treatment is facilitated.
Compared with the prior art, the invention has the beneficial effects that: the source application die body is in a blocking design, can be sequentially placed into the vagina of a patient, and can effectively reach a designated position through a narrow part; the extended part of the tail end of the source application die body is provided with a groove, the source application die body can be combined after all the source application die body enters the vagina of a patient, and a binding belt is used for fixing the source application die body at the groove, so that the source application die body is stably fixed, and the source application die body is prevented from moving when an inserting needle is placed; the tail end of the donor die body is provided with length marking compensation, so that a doctor can conveniently operate according to the scale of the inserted needle and the data of the needle inserting length.
Drawings
Figure 1 is a schematic modeling diagram of the present invention,
according to the invention, uterus, bladder, small intestine, rectum and vagina application source die bodies are drawn according to an image of a patient, a model file is generated and is imported into modeling software, wherein 1 is the small intestine, 2 is the bladder, 3 is the urethra, 4 is the application source die body, 5 is an insertion needle and a uterine cavity tube applicator, 6 is the uterus, 7 is the rectum, 8 is a groove on the extension part of the application source die body, and 9 is a protrusion for connecting and fixing the application source die body die.
Figure 2 is a schematic diagram of a modeled perspective of the present invention,
1 is rectum, 2 is uterine cavity tube applicator, 3 is uterus, 4 is insertion needle, 5 is application source die body, 6 is groove on extension part of application source die body, 7 is protuberance for connecting and fixing application source die body, 8 is small intestine and 9 bladder. The uterine cavity tube applicator is inserted into the uterus, plays a role in connecting the uterus and the applicator die body, and the insertion needles are uniformly distributed in the tumor of the uterus and do not penetrate out to penetrate into the surrounding normal organs.
Figure 3 is a schematic view of a reference prescription dose line of the present invention,
1 is rectum, 2 is a reference prescription dose line produced by applying Python, 3 is uterus, 4 is an application source die body, 5 is a groove on the extending part of the application source die body, 6 is a protrusion for connecting and fixing an application source die body die, 7 is small intestine, 8 is bladder, 9 is urethra, 10 uterine cavity tube applicator and 11 is an inserting needle from '3D printing combined brachytherapy modeling method applying Python' (patent number: 202210410966.7). The Python is used for generating a reference prescription dose line which can be rendered in real time according to the adjustment of the inserting needle, so that a doctor or a physicist can conveniently make the adjustment judgment of the inserting needle.
Figure 4 is a schematic representation of a donor phantom model file of the present invention,
1 is an inserting needle channel, the length and the direction of the inserting needle are regulated according to the condition of a patient, 2 is a uterine cavity tube applicator channel, 3 is an application source die body, and 4 is a groove on the extension part of the application source die body. At this time, the mold body is not subjected to blocking treatment.
Figure 5 is a top view of a donor phantom model file of the present invention,
1 is an inserting needle channel, 2 is a source applying die body, and 3 is a uterine cavity tube source applying device channel.
Figure 6 is a bottom view of a donor phantom model file of the invention,
1 is a uterine cavity tube applicator channel, 2 is an inserting needle channel, and 3 is an applicator die body. At this time, the donor die body is not added with length marking compensation.
Figure 7 is a bottom three-dimensional schematic view of a donor phantom model file of the present invention,
marking and compensating the length of the uterine tube 1, applying a source to the uterine tube 2, extending the tail of a source applying die body 3, marking and compensating the length of an inserting and planting needle 4 and 5, and inserting and planting needle 6. At this time, the donor die body is added with length marking compensation.
Figure 8 is a bottom three-dimensional schematic view of a donor phantom model file of the present invention,
1. and 3, marking and compensating the length of the inserting needle, 2, marking and compensating the length of the uterine cavity tube, and 4, extending the tail part of the source applying die body.
Figure 9 is a bottom parallel perspective view of a donor phantom model file of the present invention,
the length of the implantation needle is marked and compensated for 1, the implantation needle is marked and compensated for 2, the length of the uterine tube is marked and compensated for 3, the length of the uterine tube is marked and compensated for 4, the length of the uterine tube is divided into sections and calibrated lines, the uterine tube is applied with a source applicator 5, and the tail part of the application die body is extended 6. The length marking compensation part is adjusted in the perspective view, the subsection scales of the uterine cavity tube applicator and the insertion needle are adjusted and compensated to the overlapped scale lines, the measured insertion needle length is an integer, and the insertion is convenient for a doctor to insert according to the subsection scales, the length marking compensation and the insertion needle length of the insertion needle in the actual treatment.
Figure 10 is a three-dimensional schematic view of a segmented donor die of the present invention,
1 is the upper right part of the block-shaped source application die body, 2 is a uterine cavity tube source applicator channel, and 3 is an inserting needle channel; 4 is the left upper part of the block donor mold body, 5 is the lower part of the block donor mold body, 6 is the channel of the inserting needle, 7 is the groove on the extending part of the tail end of the donor mold body, and 8 is the protrusion for connecting and fixing the donor mold body.
Figure 11 is a left side view of a segmented donor die of the present invention,
1 is the left upper part of a block-type source application die body, 2 is a groove on the extended part of the tail end of the left upper part, and 3 is the length marking compensation of the inserting needle; 4, the upper right part of the block-shaped source applying die body, 5, a groove on the extended part of the tail end of the upper right part and 6, marking and compensating the length of the uterine cavity tube source applicator; 7 is the lower part of the block donor mold body, 8 is a groove on the extension part of the tail end of the lower part, and 9 is a protrusion for connecting and fixing the donor mold body mold.
Figure 12 is a right side view of a segmented donor die of the present invention,
the method comprises the following steps of 1, smoothening, 4, 5, and 6, wherein the step 1 is an inserting needle channel at the lower part of a block source applying die body, the step 2 is the lower part of the block source applying die body, the step 3 is the edge cutting of the lower part of the block source applying die body, the groove is formed in the lower tail end extension part, and the protrusion is connected with and fixed to a source applying die body die; 7 is a uterine cavity tube source applicator channel, 8 is the upper right part of a block source applicator die body, 9 is the trimming edge of the upper right part, which is subjected to smoothing treatment, 10 is a groove on the tail end extension part of the upper right part, and 11 is the length marking compensation of the uterine cavity tube source applicator; 12 is an inserting needle channel, 13 is the left upper part of the block donor die body, 14 is the trimming edge of the left upper part of the block donor die body, the trimming edge is subjected to smoothing treatment, 15 is a groove on the tail end extension part of the left upper part, and 16 is inserting needle length marking compensation.
Figure 13 is a three-dimensional schematic view of a segmented donor die of the present invention,
1 is an inserting needle channel, 2 is the left upper part of a blocking source application die body, and 3 is a sharp edge at the left upper part, and the left upper part is subjected to smoothing treatment; 4 is a needle inserting channel, 5 is a uterine cavity tube source applicator channel, 6 is the upper right part of a block source application die body, 7 is the upper right part trimming edge which is subjected to smoothing treatment, and 8 is a groove of the tail end extension part of the upper right part; 9. the method comprises the following steps of (1) inserting a needle channel, 11 cutting edges of the lower part of a block donor mold body, smoothing, 12 lower part of the block donor mold body, 13 groove of the extended part of the tail end of the lower part, and 14 protrusion for connecting and fixing a donor mold body mold.
Figure 14 is a three-dimensional schematic view of the special fixing tie of the present invention,
1 is the ribbon middle part, 2 is the ribbon head, and 3 is the ribbon afterbody. The same width of ribbon full length, slightly be less than the recess width of execution source die body tail end extension, so that put into the recess, pass the head end with the ribbon tail end, the head end uses the slipknot mode fixed, the taut tail end after the instruction position is put into to the execution source die body, it is fixed by patient's vagina parcel to execute source die body head end, the tail end is fixed by the ribbon is taut, can make each piecemeal combination of execution source die body combine for whole and remain stable, produce the slip when preventing to place the implantation needle, the influence is inserted and is planted the needle and is implanted the precision, avoid taking place to insert and plant the needle because of the direction error leads to pricking the danger of normal organ.
Detailed Description
Delineating a source application die body, a uterus and a endangered organ according to a CT image of a patient; generating a model file and importing the model file into modeling software; in the modeling process, the inserting needles are adjusted to be uniformly distributed in the target area and do not penetrate into normal organs; extending the tail end of the source application die body by 2-3 cm, and engraving a groove at a proper position of the extended part; adding the length marking compensation of the inserting needle at the tail end to enable the inserting needle length to be an integer; cutting the model file of the source application die body in a plane along the needle inserting direction as much as possible to prevent cutting off the insertion needle and the uterine cavity tube source applicator channel; smoothing sharp edges and cut edges of the cut donor mold blocks; exporting the application source die body file, and transmitting the application source die body file to a 3D printer for printing; sterilizing the printed source die blocks for later use; preparing the bladder and intestinal tract of a patient; inserting into a uterine cavity tube applicator; placing the source application module blocks to the designated positions in a grading way; after the combination is correct, a special binding belt is used for fixing the tail end extension part groove; connecting the source applying die body protrusion to the fixed source applying die body die; marking compensation and inserting needle division scales according to the needle inserting length and the length of the tail end of the source applying die body to place an inserting needle; shooting CT; making a near-distance afterloading radiotherapy plan; radiotherapy is administered.
Claims (5)
1. A3D printing source application die body block enters a narrow lacuna in brachytherapy and then is recombined and fixed, the method steps are: cutting a model file plane of a source application die body, then transmitting the model file plane to a 3D printer for printing, sequentially placing the partitioned source application die body to a specified position through a human body narrow cavity, fixing the source application die body block to enable the source application die body block to be stable into a whole, enabling a source application channel to pass through an insertion implantation needle, a source applicator or a particle implantation needle, marking and compensating the length of the tail end of the source application die body, and enabling the tail end of the source application die body to be compared with the scale of the insertion implantation needle or the particle implantation needle to implement short-distance treatment; the method is characterized in that: can enter a narrow cavity gap and recombine the fixed block source-applying die body after reaching a designated position.
2. The segmented donor die as set forth in claim 1, wherein: and the model file of the source application die body is cut on the plane in the modeling software, has smooth cut edges and contains a source application channel.
3. A planar cut as claimed in claim 2, wherein: cutting along the source applying channel without cutting off the source applying channel.
4. The segmented source-imparting phantom of claim 1, wherein: the tail end is provided with an extension part which extends out of the human body, the extension part is provided with a groove, and the extension part can be buckled in the groove by a binding belt and fastened and fixed.
5. A length-compensating marking as claimed in claim 1, characterized in that: the depth of the inserting needle or the particle implanting needle arranged in the source application channel is compensated to be an integer, so that the scale comparison operation with the inserting needle or the particle implanting needle in the actual treatment is convenient.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210619763.9A CN114939241A (en) | 2022-06-04 | 2022-06-04 | 3D printing source application die body block entering narrow lacuna recombination fixing technology in brachytherapy |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210619763.9A CN114939241A (en) | 2022-06-04 | 2022-06-04 | 3D printing source application die body block entering narrow lacuna recombination fixing technology in brachytherapy |
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| Publication Number | Publication Date |
|---|---|
| CN114939241A true CN114939241A (en) | 2022-08-26 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210619763.9A Withdrawn CN114939241A (en) | 2022-06-04 | 2022-06-04 | 3D printing source application die body block entering narrow lacuna recombination fixing technology in brachytherapy |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116258735A (en) * | 2023-05-16 | 2023-06-13 | 四川省肿瘤医院 | Cervical cancer inter-tissue insertion needle reconstruction system |
-
2022
- 2022-06-04 CN CN202210619763.9A patent/CN114939241A/en not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116258735A (en) * | 2023-05-16 | 2023-06-13 | 四川省肿瘤医院 | Cervical cancer inter-tissue insertion needle reconstruction system |
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Application publication date: 20220826 |
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