CN114939096A - Royal jelly micromolecule water solution and preparation method and application thereof - Google Patents
Royal jelly micromolecule water solution and preparation method and application thereof Download PDFInfo
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- CN114939096A CN114939096A CN202210619097.9A CN202210619097A CN114939096A CN 114939096 A CN114939096 A CN 114939096A CN 202210619097 A CN202210619097 A CN 202210619097A CN 114939096 A CN114939096 A CN 114939096A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
- A61K8/988—Honey; Royal jelly, Propolis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
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Abstract
The invention provides a royal jelly micromolecule water solution and a preparation method and application thereof, relating to the field of cosmetic raw materials. The method comprises the following steps: mixing royal jelly and ultrapure water according to the mass ratio of 1: 3-10, uniformly mixing to obtain a royal jelly diluent; filtering the diluted royal jelly solution by using membrane equipment to obtain a filtrate, and separating and filtering substances with the molecular weight of below 5000-40000 daltons by using the membrane equipment; heating the filtrate to 85-100 ℃, and preserving heat for 10-30 min; cooling the heated filtrate, filling into sterile container in clean filling region, sealing to obtain Lac Regis Apis small molecule water solution, filling temperature is not lower than 50 deg.C, and air cleanliness of clean filling region reaches 10000 levels when it is static. The royal jelly micromolecule water solution raw material prepared by the method can be stored at normal temperature, meets the requirements of the total bacterial count of the cosmetics and the standard of coliform group of the products, and avoids the high cost investment of aseptic filling hot filling equipment and a freezing warehouse.
Description
Technical Field
The invention relates to the field of cosmetic raw materials, and in particular relates to a royal jelly micromolecule water solution, a preparation method and application thereof.
Background
Royal jelly (royal jelly), also known as royal jelly, is a secretion of pharyngeal glands of young worker bees that breed larvae in honey bee hives, is a food for the larvae that will become queen bees, and is also a food for the queen bees to live.
The royal jelly contains royal jelly acid, amino acids, vitamins, minerals, and small molecular peptide substances, is nutritious, has high edible value, and can improve immunity, treat scald, improve anemia, care skin, diminish inflammation, relieve pain, regulate nervous system, and promote hematopoiesis.
Besides having edible value, royal jelly is also used as a cosmetic raw material. The royal jelly contains many nutritional ingredients and medicinal ingredients, and has effects of promoting and enhancing the vitality of epidermal cells, improving metabolism of cells, reducing accumulation of metabolites, preventing elasticity fiber degeneration and sclerosis, nourishing skin, and nourishing skin, so as to make skin soft, elastic, moistening and lustrous, and delay skin aging.
At present, various cosmetics taking royal jelly as an important raw material component are provided, and the royal jelly is taken as a raw material to be directly added, such as royal jelly vanishing cream, royal jelly beauty emulsion, royal jelly hair-growing water and the like. Also, for example, chinese patent document CN105748395A discloses a skin care product containing royal jelly, which is composed of olive oil, royal jelly, squalane, wheat germ oil, mulberry root extract, licoflavone, honeysuckle extract, polyglycerol, phenethyl alcohol, chayote extract, phaeodactylum tricornutum extract, ethyl glucoside, ethyl p-hydroxybenzoate, triethanolamine, caprylyl glycine, potassium lauryl alcohol ether phosphate and water.
In addition, the royal jelly is added into cosmetics in the form of hydrolyzed royal jelly protein (enzymolysis polypeptide), which is a product obtained by hydrolyzing royal jelly protein into smaller molecular weight by using protease, and has the effects of promoting the proliferation of epidermal cells, activating skin, resisting aging, and remarkably moisturizing and conditioning. For example, chinese patent document CN114099364A discloses a method for preparing an emulsion containing royal jelly enzymatic hydrolysis polypeptide, which comprises the steps of firstly subjecting royal jelly to enzymatic hydrolysis to decompose protein therein to obtain royal jelly polypeptide, adopting components such as beta-cyclodextrin and the like and freeze-drying to stabilize the royal jelly enzymatic hydrolysis polypeptide, maintaining the activity thereof, and mixing emulsion components and plant extracts to obtain the emulsion containing royal jelly enzymatic hydrolysis polypeptide.
The skin care dermatology compiled by the He Li and Liu Wei book indicates that: theoretically, molecules below 40000D all have an opportunity to pass through the basement membrane into the dermis, and molecules above 40000D have no opportunity to enter the dermis. When royal jelly is directly used as a raw material to prepare cosmetics, substances with large molecular weight cannot enter the dermis, so that the skin care effect of the cosmetics cannot be fully exerted.
Generally, as a raw material of cosmetics, it is necessary to meet the microbial standards of cosmetics, and therefore, the processes for producing and filling cosmetic raw materials are roughly four types: firstly, production is carried out by ultra-high temperature sterilization and sterile filling; secondly, performing production by using an ultra-high temperature sterilization and high temperature hot filling process; thirdly, ultra-high temperature sterilization and preservative addition are used for production protection; fourthly, directly placing the cosmetic raw materials in a freezing storage and transportation way for use. The four filling modes have higher fixed cost of the sterile filling equipment, the hot filling equipment and the freezing warehouse. Therefore, when the hydrolyzed royal jelly protein is used as a raw material, it is usually required to be prepared as it is, and its use is limited.
Therefore, there is a strong need in the art to provide a cosmetic material having a high content of absorbable components in royal jelly and a high storage stability. At present, no report is found on the technical scheme of cleanly filling and producing the small molecular water solution of royal jelly as the raw material of cosmetics.
Disclosure of Invention
Therefore, the technical problem to be solved by the invention is to provide a cosmetic raw material with high absorbable component content and high storage stability in royal jelly, and particularly to a royal jelly micromolecule water solution and a preparation method and application thereof.
In order to achieve the purpose, the invention provides the following technical scheme:
in a first aspect, the invention provides a preparation method of royal jelly micromolecule water solution, which comprises the following steps:
(1) mixing royal jelly and ultrapure water according to the mass ratio of 1: 3-10, uniformly mixing to obtain a royal jelly diluent;
(2) filtering the royal jelly diluent by using membrane equipment to obtain a filtrate, wherein the membrane equipment separates and filters substances with the molecular weight of below 5000-40000 daltons;
(3) heating the filtrate to 85-100 ℃, and preserving heat for 10-30 min;
(4) and cooling the heated filtrate, filling into a sterile container in a clean filling area, and sealing to obtain the small molecular water solution of royal jelly, wherein the filling temperature is not lower than 50 ℃, and the air cleanliness of the clean filling area reaches 10000 levels when being static.
Further, in the step (1), the mass ratio of the royal jelly to the ultrapure water is 1:5 to 10.
Further, in the step (1), the mass ratio of the royal jelly to the ultrapure water is 1: 5. 1: 8 or 1: 10.
further, in the step (2), the membrane device separates and filters substances with molecular weight below 5000 daltons, 10000 daltons or 40000 daltons.
Further, in the step (2), the membrane equipment is ultrafiltration membrane equipment.
Further, in the step (3), the heating temperature is 85-95 ℃, and the heat preservation time is 10-15 min.
Further, in the step (3),
heating at 95 deg.C for 10 min; or alternatively
Heating at 85 deg.C for 15 min; or
Heating at 90 deg.C for 10 min; or
The heating temperature is 85 ℃, and the heat preservation time is 10 min.
Further, in the step (4), the filling temperature is 50-65 ℃.
Further, in the step (4), the sterile container is a sterile packaging bag.
In a second aspect, the invention provides the royal jelly micromolecule water liquid obtained by the preparation method.
In a third aspect, the invention provides application of the royal jelly micromolecule water solution obtained by the preparation method in cosmetics.
The technical scheme of the invention has the following advantages:
1. the preparation method of the royal jelly micromolecule water solution provided by the invention takes ultrapure water (RO water) as production water, filters macromolecular substances which cannot enter a corium layer by using membrane equipment after diluting royal jelly, and adopts a sterile container for clean filling after heating and sterilization.
On one hand, the small molecular substances with the molecular weight of 5000-40000 daltons extracted by the membrane equipment have high content of effective components capable of acting on the dermis, and are convenient for better absorption and utilization of skin cells;
on the other hand, the royal jelly acid component contained in the royal jelly micromolecule water solution has certain natural bacteriostasis, combines with scientific process standard, strict sterilization parameters, filling process and packaging requirements, does not add any chemical substances including preservatives in the whole process, only adopts medium-low temperature clean filling, and reaches 10000 levels when the filling air cleanliness (suspended particles and settled bacteria) is static.
2. The royal jelly micromolecule water solution prepared by the invention meets the following quality standards:
a) content of Royal jelly acid (10-hydroxy-2-decenoic acid (10-HAD)): 0.03-0.25%;
b) pH value: 3.0-4.6;
c) total number of colonies: 10000CFU/mL or less;
d) coliform group/(MPN/ml): and cannot be detected.
Detailed Description
The following examples are provided to further understand the present invention, not to limit the scope of the present invention, but to provide the best mode, not to limit the content and the protection scope of the present invention, and any product similar or similar to the present invention, which is obtained by combining the present invention with other prior art features, falls within the protection scope of the present invention.
The royal jelly raw materials adopted in the embodiment conform to the regulation of GB9697-2008 royal jelly;
the ultrafiltration membrane component in the ultrafiltration membrane equipment adopted in the embodiment is purchased from Shandong gold Huffi film science and technology Co., Ltd;
the sterile packaging bag (specification 20/25 kg) adopted in the embodiment is purchased from Hangzhou Huanshen packaging New materials GmbH;
in the examples, the royal jelly acid content detection method specified in GB9697-2008 royal jelly is adopted.
The examples do not indicate specific experimental procedures or conditions, and can be performed according to the procedures or conditions of the conventional experimental procedures described in the literature in the field. The raw materials or equipment used are all conventional products which can be obtained commercially, including but not limited to the raw materials or equipment used in the examples of the present application.
Example 1
This example provides a preparation method of a royal jelly small molecule water solution, which comprises the following steps:
(1) mixing royal jelly and ultrapure water according to the mass ratio of 1:5, uniformly mixing to obtain a royal jelly diluent;
(2) filtering the royal jelly diluent obtained in the step (1) by using ultrafiltration membrane equipment to obtain a filtrate, wherein the substances with the molecular weight of less than 10000 daltons are separated and filtered by the ultrafiltration membrane equipment;
(3) heating the filtrate obtained in the step (2) to 95 ℃ in a heating tank with a jacket, and preserving the heat for 10 min;
(4) and (3) cooling the filtered solution heated in the step (3), filling the cooled filtered solution into a sterile packaging bag in a clean filling area, sealing the sterile packaging bag to obtain the small-molecular royal jelly water solution, wherein the filling temperature is 60 +/-2 ℃, and the air cleanliness (suspended particles and settled bacteria) in the clean filling area reaches 10000 levels when the air cleanliness is static.
And (3) keeping the operating environment of the steps (1) to (3) clean except that the step (4) has a requirement on the air cleanliness of the clean filling area.
Through detection, the royal jelly small molecular water solution prepared by the embodiment has the royal jelly acid (10-hydroxy-2-decenoic acid (10-HAD)) content of 0.10 percent; the pH value is 3.8; the microbial standard reaches: the total number of colonies is less than or equal to 10000CFU/mL, and coliform group/(MPN/mL) is not detected.
Example 2
The embodiment provides a preparation method of royal jelly micromolecule water solution, which comprises the following specific steps:
(1) mixing royal jelly and ultrapure water according to the mass ratio of 1: 8, uniformly mixing to obtain a royal jelly diluent;
(2) filtering the royal jelly diluent obtained in the step (1) by using ultrafiltration membrane equipment to obtain a filtrate, wherein substances with the molecular weight of below 40000 daltons are separated and filtered by the ultrafiltration membrane equipment;
(3) heating the filtrate obtained in the step (2) to 85 ℃ in a heating tank with a jacket, and preserving heat for 15 min;
(4) and (4) cooling the filtered solution heated in the step (3), filling the cooled filtered solution into a sterile packaging bag in a clean filling area, sealing the sterile packaging bag to obtain the small-molecular royal jelly water solution, wherein the filling temperature is 53 +/-2 ℃, and the air cleanliness (suspended particles and settled bacteria) in the clean filling area reaches 10000 levels when the air cleanliness is static.
And (3) keeping the operating environment of the steps (1) to (3) clean except that the step (4) has a requirement on the air cleanliness of the clean filling area.
Through detection, the royal jelly small molecular water solution prepared by the embodiment has the royal jelly acid (10-hydroxy-2-decenoic acid (10-HAD)) content of 0.07%; the pH value is 3.9; the microbial standard reaches: the total number of colonies is less than or equal to 10000CFU/mL, and coliform group/(MPN/mL) is not detected.
Example 3
The embodiment provides a preparation method of royal jelly micromolecule water solution, which comprises the following specific steps:
(1) mixing royal jelly and ultrapure water according to the mass ratio of 1: 8, uniformly mixing to obtain a royal jelly diluent;
(2) filtering the royal jelly diluent obtained in the step (1) by using ultrafiltration membrane equipment to obtain a filtrate, wherein substances with the molecular weight of below 5000 daltons are separated and filtered by the ultrafiltration membrane equipment;
(3) heating the filtrate obtained in the step (2) to 90 ℃ in a heating tank with a jacket, and preserving heat for 10 min;
(4) and (4) cooling the filtered solution heated in the step (3), filling the cooled filtered solution into a sterile packaging bag in a clean filling area, sealing the sterile packaging bag to obtain the small-molecular royal jelly water solution, wherein the filling temperature is 55 +/-2 ℃, and the air cleanliness (suspended particles and settled bacteria) in the clean filling area reaches 10000 levels when the air cleanliness is static.
Except that the step (4) has a requirement on the air cleanliness of the clean filling area, the operation environments of the steps (1) to (3) are kept clean.
Through detection, the royal jelly small molecular water solution prepared by the embodiment has the royal jelly acid (10-hydroxy-2-decenoic acid (10-HAD)) content of 0.07%; the pH value is 3.9; the microbial standard reaches: the total number of colonies is less than or equal to 10000CFU/mL, and coliform group/(MPN/mL) is not detected.
Example 4
The embodiment provides a preparation method of royal jelly micromolecule water solution, which comprises the following specific steps:
(1) mixing royal jelly and ultrapure water according to the mass ratio of 1:10, uniformly mixing to obtain a royal jelly diluent;
(2) filtering the royal jelly diluent obtained in the step (1) by using ultrafiltration membrane equipment to obtain a filtrate, wherein the substances with the molecular weight of less than 10000 daltons are separated and filtered by the ultrafiltration membrane equipment;
(3) heating the filtrate obtained in the step (2) to 85 ℃ in a heating tank with a jacket, and preserving heat for 10 min;
(4) and (3) cooling the filtered solution heated in the step (3), filling the cooled filtered solution into a sterile packaging bag in a clean filling area, sealing the sterile packaging bag to obtain the small-molecular royal jelly water solution, wherein the filling temperature is 63 +/-2 ℃, and the air cleanliness (suspended particles and settled bacteria) in the clean filling area reaches 10000 levels when the air cleanliness is static.
And (3) keeping the operating environment of the steps (1) to (3) clean except that the step (4) has a requirement on the air cleanliness of the clean filling area.
Through detection, the royal jelly small molecular water solution prepared by the embodiment has the royal jelly acid (10-hydroxy-2-decenoic acid (10-HAD)) content of 0.05 percent; the pH value is 3.9; the microbial standard reaches: the total number of colonies is less than or equal to 10000CFU/mL, and coliform group/(MPN/mL) is not detected.
Experimental example 1 determination of Material-to-Water ratio parameters
The royal jelly contains royal jelly acid components and has certain antibacterial activity, so that the selection of a proper material-water ratio is the key for realizing medium-low temperature clean filling. The experimental example aims to determine a relatively proper material-water ratio, and the specific method comprises the following steps:
weighing 500 g of royal jelly, selecting a material-water ratio (mass ratio of the royal jelly to ultrapure water) of 1:5, 1:10 and 1:20 for experiment, diluting the royal jelly with ultrapure water in proportion, filtering substances with the molecular weight below 10000 Dalton by using an ultrafiltration membrane device to obtain filtrate, heating the obtained filtrate in a heating tank with a jacket to 85 ℃, preserving heat for 10min, cooling to the normal temperature in an ultra-clean bench to obtain a small molecular water solution of the royal jelly, inoculating bacillus subtilis, culturing for 48h at 37 ℃, observing the growth condition of bacterial colonies, and simultaneously detecting the content of royal jelly acid in the small molecular water solution of the royal jelly, wherein the result is shown in Table 1.
TABLE 1 Royal jelly acid content and antibacterial effect in Lac Regis Apis small molecular water solution
It can be seen that a feed-water ratio higher than 1:10 will affect bacteriostatic properties.
Experimental example 2 determination of filling temperature
Experiments are carried out according to the highest material-water ratio 1:10 determined in the experimental example 1, and the proper filling temperature is determined by the following specific method:
weighing 500 g of royal jelly, and mixing the materials according to a material-water ratio of 1:10 diluting with ultrapure water, filtering with ultrafiltration membrane equipment to obtain filtrate with molecular weight less than 10000 Dalton, heating the filtrate in a jacketed heating tank to 85 deg.C, maintaining the temperature for 10min, filling into sterile packaging bags at normal temperature of 25 deg.C, 50 deg.C and 65 deg.C to obtain small molecular water solution of Lac Regis Apis, standing at normal temperature for 7 days, observing expansion condition and detecting colony count, the results are shown in Table 2.
TABLE 2 expansion of the small molecular water solution after storage and the total number of colonies
It was thus determined that the filling temperature should not be lower than 50 ℃.
Experimental example 3 storage stability test of Royal jelly small-molecule water solution
Preparing the royal jelly micromolecule water solution according to the following steps:
(1) taking 500 g of royal jelly, and mixing the royal jelly and ultrapure water according to the mass ratio of 1:10, uniformly mixing to obtain a royal jelly diluent;
(2) filtering the royal jelly diluent obtained in the step (1) by using membrane equipment to obtain a filtrate, wherein substances with the molecular weight of less than 10000 daltons are separated and filtered by using ultrafiltration membrane equipment;
(3) heating the filtrate obtained in the step (2) to 85 ℃ in a heating tank with a jacket, and preserving heat for 10 min;
(4) and (4) cooling the filtered solution heated in the step (3), filling the cooled filtered solution into a sterile packaging bag in a clean filling area, sealing the sterile packaging bag by a sealing cover, and obtaining the small-molecule royal jelly water solution, wherein the filling temperature is 50 ℃, and the air cleanliness (suspended particles and settled bacteria) in the clean filling area reaches 10000 grades when the water solution is static.
Except that the step (4) has a requirement on the air cleanliness of the clean filling area, the operation environments of the steps (1) to (3) are kept clean.
The prepared royal jelly micromolecule water solution is stored at normal temperature (25 ℃), and the royal jelly acid content, the pH value, the bag expanding condition and the change of the total number of bacterial colonies are tracked and observed, and the results are shown in table 3.
TABLE 3 quality index tracking result of royal jelly small molecule water solution under normal temperature storage condition
According to the test of the storage stability at normal temperature, the micro-molecular water solution of royal jelly obtained by the preparation method provided by the invention still has stable quality after being stored for 3 months and 6 months at normal temperature, is safe for microorganisms and has excellent storage stability. Tests show that the small molecular water solutions of royal jelly prepared in examples 1-4 also have excellent storage stability.
It should be understood that the above examples are only for clarity of illustration and are not intended to limit the embodiments. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. And are neither required nor exhaustive of all embodiments. And obvious variations or modifications therefrom are within the scope of the invention.
Claims (10)
1. The preparation method of the royal jelly micromolecule water liquid is characterized by comprising the following steps:
(1) mixing royal jelly and ultrapure water according to the mass ratio of 1: 3-10, uniformly mixing to obtain a royal jelly diluent;
(2) filtering the royal jelly diluent by using membrane equipment to obtain a filtrate, wherein the membrane equipment separates and filters substances with the molecular weight of below 5000-40000 daltons;
(3) heating the filtrate to 85-100 ℃, and preserving heat for 10-30 min;
(4) and cooling the heated filtrate, filling into a sterile container in a clean filling area, and sealing to obtain the small molecular water solution of royal jelly, wherein the filling temperature is not lower than 50 ℃, and the air cleanliness of the clean filling area reaches 10000 levels when being static.
2. The method for preparing royal jelly small-molecule water solution according to claim 1, wherein in the step (1), the mass ratio of royal jelly to ultrapure water is 1:5 to 10.
3. The method for preparing royal jelly small-molecule water solution according to claim 2, wherein in the step (1), the mass ratio of royal jelly to ultrapure water is 1: 5. 1: 8 or 1: 10.
4. the method for preparing royal jelly small-molecule water solution according to claim 1, wherein in the step (2), substances with molecular weight below 5000 daltons, 10000 daltons or 40000 daltons are separated and filtered by the membrane device; the membrane equipment is ultrafiltration membrane equipment.
5. The method for preparing royal jelly small-molecule water solution according to claim 1, wherein in the step (3), the heating temperature is 85 to 95 ℃ and the holding time is 10 to 15 min.
6. The method for preparing royal jelly small-molecule water solution according to claim 5, wherein in the step (3),
heating at 95 deg.C for 10 min; or
Heating at 85 deg.C, and holding for 15 min; or
Heating at 90 deg.C, and maintaining for 10 min; or
The heating temperature is 85 ℃, and the heat preservation time is 10 min.
7. The method for preparing royal jelly small-molecule water solution according to claim 1, wherein the filling temperature in the step (4) is 50-65 ℃.
8. The method for preparing a royal jelly small-molecule water solution according to claim 1, wherein in the step (4), the sterile container is a sterile packaging bag.
9. The small molecular water solution of royal jelly obtained by the preparation method according to any one of claims 1 to 8.
10. The use of the small molecular water solution of royal jelly obtained by the preparation method according to any one of claims 1 to 8 in cosmetics.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008149838A1 (en) * | 2007-06-04 | 2008-12-11 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Novel fractionation product of royal jelly, method for production of the same, and use of the same |
| CN105779549A (en) * | 2016-05-20 | 2016-07-20 | 浙江省农业科学院 | Method for preparing functional peptide from royal jelly |
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- 2022-06-01 CN CN202210619097.9A patent/CN114939096A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008149838A1 (en) * | 2007-06-04 | 2008-12-11 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Novel fractionation product of royal jelly, method for production of the same, and use of the same |
| CN105779549A (en) * | 2016-05-20 | 2016-07-20 | 浙江省农业科学院 | Method for preparing functional peptide from royal jelly |
Non-Patent Citations (1)
| Title |
|---|
| 李玫璐等: "蜂王浆主蛋白( MRJPs) 超滤分离工艺优化及产物质量分析", 《浙江大学学报( 农业与生命科学版)》, vol. 40, no. 5, pages 526 - 532 * |
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