CN114931704A - Stimulating coil - Google Patents

Stimulating coil Download PDF

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Publication number
CN114931704A
CN114931704A CN202210604679.XA CN202210604679A CN114931704A CN 114931704 A CN114931704 A CN 114931704A CN 202210604679 A CN202210604679 A CN 202210604679A CN 114931704 A CN114931704 A CN 114931704A
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CN
China
Prior art keywords
coil
stimulation
layer
wire
wires
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202210604679.XA
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Chinese (zh)
Inventor
李想
张文哲
孙传铸
严潇
郭永涛
阮清源
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Suzhou Brain Control Brain Science And Technology Co ltd
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Suzhou Brain Control Brain Science And Technology Co ltd
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Priority to CN202210604679.XA priority Critical patent/CN114931704A/en
Publication of CN114931704A publication Critical patent/CN114931704A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00Magnetotherapy
    • A61N2/02Magnetotherapy using magnetic fields produced by coils, including single turn loops or electromagnets
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00Magnetotherapy
    • A61N2/004Magnetotherapy specially adapted for a specific therapy
    • A61N2/006Magnetotherapy specially adapted for a specific therapy for magnetic stimulation of nerve tissue

Abstract

Embodiments of the present invention provide a stimulation coil, which includes a first coil located on a first layer, a second coil located on a second layer, a third coil located on a third layer, and a fourth coil located on a fourth layer, wherein the first coil and the fourth coil are located on the same side and are coaxial, the second coil and the third coil are located on the other side and are coaxial, and a partial overlapping region exists in the first coil, the second coil, the third coil, and the fourth coil. According to the stimulating coil provided by the embodiment of the invention, because the first coil, the second coil, the third coil and the fourth coil have partial overlapping areas, the distances of the central axes at two sides of the stimulating coil are closer, and when pulse current is introduced into the stimulating coil, the focusing performance of an induced electric field excited in a space is better.

Description

Stimulating coil
Technical Field
The embodiment of the invention relates to the technical field of medical equipment, in particular to a stimulating coil.
Background
Magnetic stimulation therapy is a non-destructive, painless, non-contact and non-invasive technology in modern medicine, and has wide application in research in the field of neuroscience and diagnosis, treatment and rehabilitation of clinical medicine. The basic principle is the faraday electromagnetic induction principle: the time-varying current passes through the stimulating coil, a time-varying induction magnetic field is generated around the stimulating coil, and the induction magnetic field acts on the biological tissue to generate induction current for local biological tissue, so that the membrane potential depolarization of nerve fibers is caused, an action potential is generated, and biological effects such as excitation or inhibition of excitation, muscle contraction, hormone secretion, synaptic modulation and the like of nerve cells are caused, thereby achieving the purpose of treatment. Magnetic Stimulation may be applied to the brain nerves, which are commonly referred to as Transcranial Magnetic Stimulation (TMS), and also to peripheral nerves.
Because the brain structure is accurate, in order to realize accurate stimulation and avoid or reduce the fact that the nerve cells in the non-target area are exposed in a stronger induction electric field to interfere the magnetic stimulation effect, the distribution of the intracranial induction electric field generated by the stimulation coil needs to have good focusing property. A magnetic stimulation system typically includes a pulse generator, a controller, and a stimulation coil. The characteristics of the pulsed magnetic field output by the magnetic stimulation system and the characteristics of the induced electric field generated in the brain, including the focality, are mainly determined by the stimulation coil, and further mainly determined by the geometry of the stimulation coil.
Common stimulating coils include circular coils, splayed coils, butterfly coils, H-coils, and the like. However, the prior art stimulating coils have insufficient focusability.
Disclosure of Invention
Embodiments of the present invention provide a stimulation coil to overcome the problem of insufficient focusing of the prior art stimulation coil.
In a first aspect, embodiments of the present invention provide a stimulation coil, including:
the first coil is positioned on the first layer, the second coil is positioned on the second layer, the third coil is positioned on the third layer, and the fourth coil is positioned on the fourth layer;
the first coil and the fourth coil are positioned on the same side and are coaxial, and the second coil and the third coil are positioned on the other side and are coaxial;
the first coil, the second coil, the third coil, and the fourth coil present a partial overlap region.
Optionally, the range of the partial overlap region is at most: the first coil and the fourth coil cover through holes of the second coil and the third coil; the second coil and the third coil cover through holes of the first coil and the fourth coil.
Optionally, the first coil, the second coil, the third coil, and the fourth coil have an innermost circumference ring with a diameter in a range of 20mm to 60mm and an outermost circumference ring with a diameter in a range of 60mm to 120 mm.
Optionally, the current in the first coil and the fourth coil flows in a direction opposite to the current in the second coil and the third coil.
Optionally, the first coil, the second coil, the third coil, and the fourth coil are connected in series.
Optionally, the first coil is connected in series with the fourth coil, and the second coil is connected in series with the third coil.
Optionally, the wires used to wind the stimulation coil are: round wire, round hole wire, square round hole wire, rectangular wire, multi-wire parallel or litz wire.
Optionally, when the wires for winding the stimulation coil are the round hole wires and the square hole wires, the round holes of the wires are used for being filled with cooling liquid for heat dissipation.
Optionally, the first coil, the second coil, the third coil, and the fourth coil are shaped to: circular, square or oval.
The stimulation coil provided by the embodiment of the invention comprises a first coil positioned on a first layer, a second coil positioned on a second layer, a third coil positioned on a third layer and a fourth coil positioned on a fourth layer, wherein the first coil and the fourth coil are positioned on the same side and are coaxial, the second coil and the third coil are positioned on the other side and are coaxial, and the first coil, the second coil, the third coil and the fourth coil have a partial overlapping area. According to the stimulation coil provided by the embodiment of the invention, as the first coil, the second coil, the third coil and the fourth coil are in partial overlapping areas, the distances between the central axes at two sides of the stimulation coil are closer, and when pulse current is introduced into the stimulation coil, the focusing performance of an induced electric field excited in a space is better.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings needed to be used in the description of the embodiments or the prior art will be briefly introduced below, and it is obvious that the drawings in the following description are some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to these drawings without creative efforts.
Fig. 1 is a schematic diagram of a stimulation coil according to an embodiment of the present invention;
FIG. 2 is a schematic diagram of a stimulation coil lead of the type provided by an embodiment of the present invention;
FIG. 3 is a schematic diagram of several shapes of stimulation coils provided by embodiments of the present invention;
FIG. 4 is a schematic diagram of another stimulation coil configuration provided by embodiments of the present invention;
FIG. 5 is a schematic diagram of a further stimulation coil provided by an embodiment of the present invention;
fig. 6 is a schematic structural diagram of another stimulation coil provided by an embodiment of the invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are some, but not all, embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
It should be noted that the terms describing the relative positional relationship such as "up", "down", "left", "right", "front", "back", "inside", "outside", "horizontal", "vertical" and the like in the embodiments of the present invention are only relative concepts or described based on examples in the drawings of the specification, and the technical solutions of the embodiments of the present invention are not limited to specific orientations.
The embodiment of the invention provides a stimulation coil, which comprises a first coil positioned on a first layer, a second coil positioned on a second layer, a third coil positioned on a third layer and a fourth coil positioned on a fourth layer, wherein the first coil and the fourth coil are positioned on the same side and are coaxial, the second coil and the third coil are positioned on the other side and are coaxial, and the first coil, the second coil, the third coil and the fourth coil have partial overlapping areas. The stimulating coil provided by the embodiment of the invention has better focusing performance because the first coil, the second coil, the third coil and the fourth coil have partial overlapping areas. Meanwhile, the first coil positioned on the first layer and the fourth coil positioned on the fourth layer are positioned on the same side and are coaxial, the second coil positioned on the second layer and the third coil positioned on the third layer are positioned on the other side and are coaxial, and the distribution structure ensures that the electric field distribution of the stimulation coil on any plane below is symmetrical and is equivalent to the distribution of the splayed coils.
The technical solutions of the present invention will be described in detail below with reference to several specific embodiments, which may be combined with each other, and the same or similar concepts or processes may not be described in detail in some embodiments.
Fig. 1 is a schematic structural diagram of a stimulation coil according to an embodiment of the present invention, and as shown in fig. 1, the stimulation coil may include:
a first coil 110 at the first layer, a second coil 120 at the second layer, a third coil 130 at the third layer, and a fourth coil 140 at the fourth layer.
Illustratively, referring to FIG. 1, the first, second, third, and fourth layers are intended to represent four layers sequentially upward or sequentially downward (the illustration is for example sequentially upward) in the longitudinal direction.
The first coil 110, the second coil 120, the third coil 130 and the fourth coil 140 are formed by winding wires, each coil includes a through hole in the center, with continued reference to fig. 1, the first coil 110 includes a through hole 119, the second coil 120 includes a through hole 129, the third coil 130 includes a through hole 139, and the fourth coil 140 includes a through hole 149. The loop wound with wire closest to the through hole may be referred to as the innermost loop and the loop wound with wire furthest from the through hole may be referred to as the outermost loop.
The first coil 110, the second coil 120, the third coil 130, and the fourth coil 140 may have an innermost circumference having a diameter ranging from 20mm to 60mm, and an outermost circumference having a diameter ranging from 60mm to 120 mm. Since the diameter of the innermost circumference ring and the diameter of the outermost circumference ring affect the inductance, the stimulation depth, the focusing property and the like of the stimulation coil, the diameters can be adjusted according to the specific application scene of the stimulation coil.
In one possible implementation, the first coil 110, the second coil 120, the third coil 130, and the fourth coil 140 may have an innermost circumference ring with a diameter ranging from 20mm to 30mm, and an outermost circumference ring with a diameter ranging from 80mm to 100 mm. In this case, the stimulating coil can obtain a good focusing property under the condition that the inductance and the stimulation depth are relatively balanced.
In an embodiment of the present invention, the lead for winding the stimulation coil may be: round wire, round wire, square wire, rectangular wire, multiple wire parallel, litz wire, or other types of wires. Fig. 2 is a schematic diagram of a stimulation coil lead type provided by an embodiment of the present invention. As shown in fig. 2, for example, fig. 1 (a) is a schematic cross-sectional view of a circular wire, fig. 2 (b) is a schematic cross-sectional view of a circular round wire, fig. 2 (c) is a schematic cross-sectional view of a square round wire, fig. 2 (d) is a schematic cross-sectional view of a rectangular wire, fig. 2 (e) is a schematic cross-sectional view of a plurality of wires connected in parallel into a column, fig. 2 (f) is a schematic cross-sectional view of a plurality of wires connected in parallel into a strand, and fig. 2 (g) is a schematic cross-sectional view of a litz wire.
When the wire used for winding the stimulating coil adopts a round hole wire or a square hole wire, the round hole of the wire can be used for cooling liquid to dissipate heat.
In the embodiment of the present invention, the first coil 110, the second coil 120, the third coil 130, and the fourth coil 140 may have the following shapes: circular, square, oval, regular pentagon, or other irregular shapes. No matter what shape the coils are in, it is within the scope of the present invention when four coils satisfy the features described in the embodiments of the present invention. Illustratively, fig. 3 is a schematic diagram of several shapes of stimulation coils provided by embodiments of the present invention. Fig. 3 (a) is a schematic top view of a circular stimulation coil, fig. 3 (b) is a schematic top view of an elliptical stimulation coil, and fig. 3 (c) is a schematic top view of a square stimulation coil.
The first coil 110 and the fourth coil 140 are located on the same side and are coaxial, and the second coil 120 and the third coil 130 are located on the other side and are coaxial.
Illustratively, with continued reference to fig. 1, the first coil 110 and the fourth coil 140 are located on the right side and have the same first central axis 210; the second coil 120 and the third coil 130 are located on the left side and have the same second central axis 220.
There is a partial overlap region for the first coil 110, the second coil 120, the third coil 130, and the fourth coil 140.
Illustratively, with continued reference to fig. 1, there is a common overlap region in the longitudinal direction for first coil 110, second coil 120, third coil 130, and fourth coil 140, referring to first coil overlap region 111, second coil overlap region 121, third coil overlap region 131, and fourth coil overlap region 141 in the illustration of fig. 1.
Because the stimulation coil has a partial overlapping area, the distance between the first central axis 210 and the second central axis 220 on both sides of the stimulation coil is closer, and when the stimulation coil is electrified with pulse current, the focusing performance of the induced electric field excited in the space is better.
In the embodiment of the invention, the range of the partial overlapping area can be adjusted according to the actual situation.
Fig. 4 is a schematic structural diagram of another stimulation coil provided by the embodiment of the invention, wherein, as shown in fig. 4 (a), the range of the partial overlapping region is maximum: a first coil 110 and a fourth coil 140 covering the through holes of the second coil 120 and the third coil 130; the second coil 120 and the third coil 130 cover the through holes of the first coil 110 and the fourth coil 140. The through holes of the second coil 120 and the third coil 130 are specifically the through hole 129 or the through hole 139, and the through holes of the first coil 110 and the fourth coil 140 are specifically the through hole 110 or the through hole 149.
As shown in fig. 4 (b), the range of the partial overlap region is at least zero, i.e., there is no partial overlap region in the first, second, third and fourth coils 110, 120, 130 and 140.
The larger the extent of the partially overlapping region, the better the focusability of the stimulation coil.
In the embodiment of the present invention, the current flows in the first coil 110 and the fourth coil 140 in the opposite direction to the current flows in the second coil 120 and the third coil 130.
Illustratively, when the directions of the currents in the first coil 110 and the fourth coil 140 are both clockwise, the directions of the currents in the second coil 120 and the third coil 130 are both counterclockwise. Alternatively, when the directions of the currents in the first and fourth coils 110 and 140 are both counterclockwise, the directions of the currents in the second and third coils 120 and 130 are both clockwise.
In one possible implementation, the first coil 110, the second coil 120, the third coil 130, and the fourth coil 140 are connected in series.
Taking the example that the wire used for winding the stimulation coil is a circular wire, and the shape of the stimulation coil is circular, fig. 5 is a schematic structural diagram of another stimulation coil provided in the embodiment of the present invention. Fig. 5 (a) is a front view, fig. 5 (b) is a right side view, fig. 5 (c) is a top view, and fig. 5 (d) is a perspective view. Referring to the above-mentioned views, the innermost circumference of the first coil 110 is connected to the outermost circumference of the second coil 120, the innermost circumference of the second coil 120 is connected to the innermost circumference of the third coil 130, the outermost circumference of the third coil 130 is connected to the innermost circumference of the fourth coil 140, and the outermost circumference of the first coil 110 and the outermost circumference of the fourth coil 140 have input and output terminals, respectively, connected to the magnetic field generator.
In another possible implementation, the first coil 110 is connected in series with the fourth coil 140, and the second coil 120 is connected in series with the third coil 130.
Taking the round wire as the wire for winding the stimulation coil, and the round shape as the example for explaining, fig. 6 is a schematic structural diagram of another stimulation coil provided by the embodiment of the invention. Fig. 6 (a) is a front view, fig. 6 (b) is a right side view, fig. 6 (c) is a top view, and fig. 6 (d) is a perspective view. Referring to the above-described views, the innermost circumference of the first coil 110 is connected to the innermost circumference of the fourth coil 140, the innermost circumference of the second coil 120 is connected to the innermost circumference of the third coil 130, the outermost circumference of the first coil 110 leads to a first input terminal, the outermost circumference of the fourth coil 140 leads to a first output terminal, the outermost circumference of the second coil 120 leads to a second input terminal, and the outermost circumference of the third coil 130 leads to a second output terminal.
One possible implementation manner is as follows: the first input end and the second input end are connected in parallel and then connected to the output end of the magnetic field generator, and the first output end and the second output end are connected in parallel and then connected to the input end of the magnetic field generator.
Another possible implementation is: the first input end and the first output end are connected with the first magnetic field generator, and the second input end and the second output end are connected with the second magnetic field generator.
The stimulation coil provided by the embodiment of the invention comprises a first coil positioned on a first layer, a second coil positioned on a second layer, a third coil positioned on a third layer and a fourth coil positioned on a fourth layer, wherein the first coil and the fourth coil are positioned on the same side and are coaxial, the second coil and the third coil are positioned on the other side and are coaxial, and the first coil, the second coil, the third coil and the fourth coil have a partial overlapping area. The current flow in the first coil and the fourth coil is opposite to the current flow in the second coil and the third coil. According to the stimulating coil provided by the embodiment of the invention, because the first coil, the second coil, the third coil and the fourth coil have partial overlapping areas, the distances of the central axes at two sides of the stimulating coil are closer, and when pulse current is introduced into the stimulating coil, the focusing performance of an induced electric field excited in a space is better.
In the comsol, finite element simulation is adopted, and compared with a standard splayed coil, the area of a Half Power Region (HPR) of the stimulation coil on a plane 30mm below the stimulation coil is only 70% of the area of the HPR of the standard splayed coil on the plane 30mm, namely, the focusing is improved by 30% compared with the splayed coil.
According to the stimulation coil provided by the embodiment of the invention, the first coil positioned on the first layer and the fourth coil positioned on the fourth layer are positioned on the same side and are coaxial, and the second coil positioned on the second layer and the third coil positioned on the third layer are positioned on the other side and are coaxial, so that the distribution structure enables the electric field distribution of the stimulation coil on any plane below to be symmetrical and is equivalent to the distribution of the splayed coils.
Those of ordinary skill in the art will understand that: all or a portion of the steps of implementing the above-described method embodiments may be performed by hardware associated with program instructions. The foregoing program may be stored in a computer-readable storage medium. When executed, the program performs steps comprising the method embodiments described above; and the aforementioned storage medium includes: various media that can store program codes, such as ROM, RAM, magnetic or optical disks.
Finally, it should be noted that: the above embodiments are only used to illustrate the technical solution of the present invention, and not to limit the same; while the invention has been described in detail and with reference to the foregoing embodiments, it will be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; and these modifications or substitutions do not depart from the spirit of the corresponding technical solutions of the embodiments of the present invention.

Claims (9)

1. A stimulation coil, comprising:
the first coil is positioned on the first layer, the second coil is positioned on the second layer, the third coil is positioned on the third layer, and the fourth coil is positioned on the fourth layer;
the first coil and the fourth coil are positioned on the same side and are coaxial, and the second coil and the third coil are positioned on the other side and are coaxial;
the first coil, the second coil, the third coil, and the fourth coil present a partial overlap region.
2. Stimulation coil according to claim 1, characterized in that the partial overlap region extends maximally: the first coil and the fourth coil cover through holes of the second coil and the third coil; the second coil and the third coil cover the through holes of the first coil and the fourth coil.
3. The stimulation coil of claim 1, wherein the first, second, third, and fourth coils have an innermost circumference in the range of 20mm to 60mm in diameter and an outermost circumference in the range of 60mm to 120mm in diameter.
4. The stimulation coil of claim 1, wherein the current flow in the first and fourth coils is opposite to the current flow in the second and third coils.
5. The stimulation coil of claim 4, wherein the first coil, the second coil, the third coil, and the fourth coil are connected in series.
6. The stimulation coil of claim 4, wherein the first coil is in series with the fourth coil, and the second coil is in series with the third coil.
7. The stimulation coil as recited in any of claims 1-6, wherein the wires used to wind the stimulation coil are: round wire, round hole wire, square round hole wire, rectangular wire, multi-wire parallel or litz wire.
8. The stimulation coil of claim 7, wherein when the wires for winding the stimulation coil are the round hole wires and the square round hole wires, the round holes of the wires are used for passing cooling liquid to dissipate heat.
9. Stimulation coil according to any of the claims 1-6, characterized in that the first coil, the second coil, the third coil, and the fourth coil are shaped as: circular, square or oval.
CN202210604679.XA 2022-05-31 2022-05-31 Stimulating coil Pending CN114931704A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI821054B (en) * 2022-11-29 2023-11-01 財團法人金屬工業研究發展中心 Transcranial magnetic stimulation 3d coil device and equipment

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI821054B (en) * 2022-11-29 2023-11-01 財團法人金屬工業研究發展中心 Transcranial magnetic stimulation 3d coil device and equipment

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