CN114917479A - Transcranial magnetic pulse interference filtering method and system and electronic equipment - Google Patents
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Abstract
The invention provides a transcranial magnetic pulse interference filtering method, a transcranial magnetic pulse interference filtering system and electronic equipment, wherein the transcranial magnetic pulse interference filtering method comprises the following steps: carrying out magnetic stimulation and electric signal acquisition on a test object, wherein a feedback signal of the test object to the electric signal acquisition is zero; acquiring a magnetic stimulation signal and an electric signal based on the initial adaptive filter, and training the initial adaptive filter to obtain a final adaptive filter; and based on the final adaptive filter, carrying out magnetic stimulation and electric signal acquisition on the designated part of the user. According to the invention, by adopting the adaptive filter, a training stage that the electric signal is zero is firstly carried out, training is carried out by utilizing a test object of a non-muscle object, and the acquired electric signal is zero, so that the pulse interference signal and the electric signal can be effectively divided in the testing stage, the adaptive filter realizes the targeted identification of the pulse interference signal in the magnetic stimulation, the pulse interference signal can be targeted filtered in the actual work, and the acquisition of the electric signal is not influenced.
Description
Technical Field
The invention relates to the technical field of transcranial magnetic stimulation interference filtering, in particular to a transcranial magnetic pulse interference filtering method, a system and electronic equipment.
Background
Because of the characteristics of painlessness, non-invasiveness, rapidness and convenience of transcranial magnetic stimulation (TMS for short), the method has become one of important research directions in the aspect of neurophysiological detection. Has been widely accepted and applied since the invention in the 80 s. The application is expanded from simple diagnosis and evaluation to treatment, and the research on the safety performance and the action mechanism of the medicine also makes great progress. Has good therapeutic effect on Parkinson disease, epilepsy and related dyskinesia, depression and mood disorder, apoplexy, schizophrenia, chronic pain, etc.
The motor evoked potential (hereinafter referred to as MEP) refers to the application or stimulation of the cortical region or spinal cord to generate excitation, and changes the anterior horn cells of the spinal cord or the motor fibers of peripheral nerves through a descending conduction path, so as to objectively evaluate the motor conduction function and reflect the functional status of the motor system.
The transcranial magnetic motion evoked potential means that TMS and MEP are used in combination, the action process is that a magnetic stimulation brain motion area or an efferent pathway thereof is used, an efferent pathway and effector muscles below a stimulation point record electric response, the functional state of downlink conduction can be directly reflected, the reflecting of the motion functional state is more direct and sensitive than the reflecting of the motion functional state through a somatosensory evoked potential in the prior art, and meanwhile, the transcranial magnetic motion evoked potential has the advantages of no damage, strong penetration, stability, reliability and the like, and can be used as a method for objectively detecting the nerve motion conduction function.
Pulse interference is inevitably generated in the TMS magnetic stimulation process, and the signal acquisition process of the MEP is influenced by the pulse interference to distort the acquired signals. For example, as shown in fig. 1, the time period from the start of artificial stimulation to the time when the negative phase wave (upward wave) of the muscle action potential deviates from the baseline starting point is a latency period, while the time during which electrical interference exists during stimulation output is generally 0.05-1.0ms, and the latency period of the exercise evoked potential is generally about 21ms, so that electrical interference during transcranial magnetic stimulation exists in the latency period.
Disclosure of Invention
The invention provides a transcranial magnetic pulse interference filtering method, a transcranial magnetic pulse interference filtering system and electronic equipment, and aims to solve the problem that pulse interference generated by magnetic stimulation can distort motion-evoked potential acquisition signals when transcranial magnetic motion evoked potentials are used at present.
The invention aims to solve the technical problem and provides a transcranial magnetic pulse interference filtering method, which comprises the following steps: carrying out magnetic stimulation and electric signal acquisition on a test object, wherein a feedback signal of the test object to the electric signal acquisition is zero; acquiring a magnetic stimulation signal and an electric signal based on the initial adaptive filter, and training the initial adaptive filter to obtain a final adaptive filter; and based on the final adaptive filter, carrying out magnetic stimulation and electric signal acquisition on the designated part of the user.
Preferably, training the initial adaptive filter specifically includes the following steps: marking an initial moment based on a trigger signal of magnetic stimulation, wherein the magnetic stimulation is provided with a pulse interference signal; the initial adaptive filter sends out a corresponding cancellation signal from the initial moment based on the pulse interference signal; and continuously updating the cancellation signal and the pulse interference signal by the initial adaptive filter, and merging the cancellation signal and the pulse interference signal until the cancellation signal and the pulse interference signal are completely cancelled to obtain the final adaptive filter.
Preferably, the process of updating the cancellation signal by the initial adaptive filter includes: the initial adaptive filter outputs a corresponding offset signal based on the received pulse interference signal; and combining the offset signal and the pulse interference signal, judging whether a combination result is zero, if so, obtaining a final adaptive filter, and if not, repeating the steps.
Preferably, the step of performing magnetic stimulation and electrical signal acquisition on the user specifically comprises: stimulating a designated part of a user by a transcranial magnetic stimulation coil; collecting an electric signal of a motion-induced potential of a stimulation part; and filtering the pulse interference signal by a final adaptive filter and outputting a final muscle electric signal.
The invention also provides a transcranial magnetic pulse interference filtering system, which comprises: the test unit is used for carrying out magnetic stimulation and electric signal acquisition on a test object, and a feedback signal of the test object to the electric signal acquisition is zero; the filtering identification unit is used for acquiring a magnetic stimulation signal and an electric signal based on the initial adaptive filter, training the initial adaptive filter and acquiring a final adaptive filter; and the stimulation acquisition unit is used for carrying out magnetic stimulation and electric signal acquisition on the designated part of the user based on the final adaptive filter.
The invention also provides an electronic device comprising a memory and a processor, wherein the memory stores a computer program, and the computer program is configured to execute the transcranial magnetic pulse interference filtering method in any one of the above methods when running; the processor is arranged to execute the transcranial magnetic pulse interference filtering method in any one of the above through the computer program.
Compared with the prior art, the transcranial magnetic pulse interference filtering method, the transcranial magnetic pulse interference filtering system and the electronic equipment provided by the invention have the following advantages:
by adopting the adaptive filter, the training stage that the electric signal is zero is firstly carried out, the test object of a non-muscle object is utilized for training, the acquired electric signal is zero, the pulse interference signal and the electric signal can be effectively divided in the testing stage, the adaptive filter realizes the pertinence identification of the pulse interference signal in the magnetic stimulation, the pulse interference signal can be pertinently filtered in the actual work, and the acquisition of the electric signal cannot be influenced. Meanwhile, the scheme adopts the test object to enable the adaptive filter to carry out targeted identification on the electric signal, and the scheme is not a traditional frequency identification mode, so that excessive filtering on signal filtering can be reduced, and the filtering effect is improved. Furthermore, the scheme combines the iterative computation of the adaptive filtering and continuously updates the offset signal until the final result, so that the scheme can be close to completely filtering the interference signal and has high filtering efficiency.
Drawings
Fig. 1 is a schematic diagram of a motor potential acquired by transcranial magnetic stimulation in the prior art.
Fig. 2 is a flowchart of a transcranial magnetic pulse interference filtering method according to a first embodiment of the present invention.
Fig. 3 is an exemplary diagram of an initial adaptive filter during a training process.
Fig. 4 is a flowchart of step S2 in a transcranial magnetic pulse interference filtering method according to a first embodiment of the present invention.
Fig. 5 is a flowchart of step S3 in the transcranial magnetic pulse interference filtering method according to the first embodiment of the present invention.
Fig. 6 is an exemplary diagram of the final adaptive filter in the filtering process.
Fig. 7 is a block diagram of a transcranial magnetic pulse interference filtering system according to a second embodiment of the invention.
Fig. 8 is a block diagram of an electronic device according to a third embodiment of the invention.
Description of reference numerals:
1. a test unit; 2. a filtering identification unit; 3. a stimulus acquisition unit;
10. a memory; 20. a processor.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
Referring to fig. 2, a transcranial magnetic pulse interference filtering method according to a first embodiment of the present invention includes the following steps:
step S1: and carrying out magnetic stimulation and electric signal acquisition on the test object, wherein the feedback signal of the test object to the electric signal acquisition is zero.
Step S2: and acquiring a magnetic stimulation signal and an electric signal based on the initial adaptive filter, and training the initial adaptive filter to obtain a final adaptive filter.
Step S3: and based on the final adaptive filter, carrying out magnetic stimulation and electric signal acquisition on the designated part of the user.
It can be understood that, in step S1, firstly, the transcranial magnetic stimulation device and the exercise-induced potential device are used to perform magnetic stimulation and electrical signal collection on a test object, and the test object has zero electrical signal collection feedback signal, for example, a stone or a wood block, and since the exercise-induced potential collection object is an electrical signal of muscle, when the test object faces the stone or the wood block, the corresponding electrical signal cannot be fed back, so only the stimulation signal and the pulse interference signal generated by the magnetic stimulation are provided.
It can be understood that, in step S2, through the stimulation effect of step S1, the initial adaptive filter acquires the interference signal and the electrical signal, and since the electrical signal acquired in step S1 is zero, only the interference signal exists at this time. For example, as shown in fig. 3, the interference signal t (n) during stimulation is collected, and the input effective collected signal x (n) is 0, y (n) + t (n) + x (n) t (n). y (n) -is a cancellation signal, which is generated after the LMS adaptive filter collects the interference signal t (n), and e (n) ═ y (n) + + y (n) -needs to make e (n) gradually zero, i.e., y (n) + + y (n) -0, and finally the LMS adaptive filter generates y (n) -t (n), which means that the LMS adaptive filter outputs a cancellation signal combined with the interference signal to zero.
It can be understood that in step S2, since the initial adaptive filter receives only the interference signal without the electrical signal of the muscle while training, the final adaptive filter obtained after step S2 forms the recognition of the interference signal.
It can be understood that, in step S3, based on the obtained final adaptive filter, the pulse interference signal of the magnetic stimulation can be filtered out in the normal magnetic stimulation and muscle electrical signal acquisition, and since the final adaptive filter forms the identification of the interference signal, when the signal is filtered, only the pulse interference signal in the signal is filtered out without affecting the effective muscle electrical signal, so that the filtering of the interference of the electrical signal acquisition is formed.
Referring to fig. 4, in step S2, the training of the initial adaptive filter specifically includes the following steps:
step S21: marking the initial moment based on the trigger signal of the magnetic stimulation with the pulse interference signal.
Step S22: the initial adaptive filter sends out a corresponding cancellation signal from an initial time based on the impulse interference signal.
Step S23: and continuously updating the cancellation signal and the pulse interference signal by the initial adaptive filter, and merging the cancellation signal and the pulse interference signal until the cancellation signal and the pulse interference signal are completely cancelled to obtain the final adaptive filter.
It will be appreciated that in step S21, when the transcranial magnetic stimulation device receives the stimulation command, a trigger signal is sent out in the system to indicate the start of the stimulation operation, and the timer starts to mark the initial time and start timing, and simultaneously, the interference signal is generated.
It is understood that in step S22, the adaptive filter outputs a corresponding cancellation signal, i.e., y (n), based on the interference signal, and the result of the adaptive filter is that e (n) ═ y (n) ++ y (n) —, such that e (n) is zero.
It is understood that, in step S23, since the initial adaptive filter cannot output an accurate cancellation signal immediately, it needs to perform multiple iterative updates, and e (n) gradually goes to zero until y (n) + + y (n) -0. And finally, after the training of the adaptive filter is finished, the impulse interference signal under the TMS system can be identified, and if a different TMS system is replaced, the adaptive filter needs to be retrained and identified.
It is to be understood that, in step S23, the process of updating the cancellation signal by the initial adaptive filter includes:
step S231: the initial adaptive filter outputs a corresponding cancellation signal based on the received pulse interference signal.
Step S232: and combining the offset signal and the pulse interference signal, judging whether a combination result is zero, if so, obtaining a final adaptive filter, and if not, repeating the steps.
It can be understood that, in step S232, the initial adaptive filter performs iterative calculation of cancellation signal output, and the corresponding cancellation signal is continuously updated according to the interference signal.
Referring to fig. 5, in step S3, the step of performing magnetic stimulation and electric signal collection on the user specifically includes:
step S31: a transcranial magnetic stimulation coil stimulates a designated site of a user.
Step S32: and collecting the electric signals of the motion-induced potentials of the stimulation parts.
Step S33: and (4) filtering the pulse interference signal by a final adaptive filter and then outputting a final muscle electric signal.
It is to be understood that in step S31, the final adaptive filter after training is applied to the magnetic stimulation and exercise-induced potential acquisition, and the transcranial magnetic stimulation coil in the TMS system stimulates the user' S designated part, which is the part to be treated by the user, such as the head.
It can be understood that, in step S33, the MEP detects the muscle electrical signal at the designated location of the user, and since the final adaptive filter only identifies the impulse interference signal, only the impulse interference signal is filtered out, and the muscle electrical signal is not affected. For example, as shown in fig. 6, y (n) + includes an interference signal t (n) and an effective signal x (n), that is, y (n) +═ t (n) + x (n). At this time, e (n) is the final generated signal, e (n) ═ y (n) ++ y (n) — (t) (n) + x (n) -t (n) ═ x (n) — (n) ═ x (n). To this end, the interference signals t (n) are filtered out. The resulting signal e (n) ═ x (n).
Referring to fig. 7, a transcranial magnetic pulse interference filtering system is further provided according to a second embodiment of the present invention. For performing the transcranial magnetic pulse interference filtering method in the first embodiment, the transcranial magnetic pulse interference filtering system may include:
the test unit 1 is configured to execute the step S1, and is configured to perform magnetic stimulation and electrical signal acquisition on the test object, where a feedback signal of the test object to the electrical signal acquisition is zero.
The filtering identification unit 2 is configured to execute the step S2, and is configured to train the initial adaptive filter based on the magnetic stimulation signal and the electrical signal obtained by the initial adaptive filter, so as to obtain a final adaptive filter.
And a stimulation collecting unit 3 for executing the step S3 to perform magnetic stimulation and electric signal collection on the designated part of the user based on the final adaptive filter.
It is understood that, in the system of this embodiment, a unit for implementing the training of the initial adaptive filter in the first embodiment may also be included.
Specifically, the filtering identification unit 2 further includes:
a trigger unit for executing the step S21, and marking an initial time based on a trigger signal of the magnetic stimulation with a pulse interference signal.
A cancellation unit, configured to execute the above step S22, and configured to initiate the adaptive filter to send out a corresponding cancellation signal from an initial time based on the impulse interference signal.
And an iteration unit, configured to execute step S23 described above, configured to continuously update the initial adaptive filter to merge the cancellation signal and the impulse interference signal until the cancellation signal and the impulse interference signal are completely cancelled, and obtain a final adaptive filter.
Referring to fig. 8, a third embodiment of the present invention provides an electronic device for implementing the transcranial magnetic pulse interference filtering method, where the electronic device includes a memory 10 and a processor 20, the memory 10 stores therein an arithmetic computer program, and the arithmetic computer program is configured to execute the steps in any of the above embodiments of the transcranial magnetic pulse interference filtering method when the arithmetic computer program is executed. The processor 20 is configured to execute the steps of any one of the above embodiments of the transcranial magnetic pulse interference filtering method through the computer program.
Optionally, in this embodiment, the electronic device may be located in at least one network device of a plurality of network devices of an arithmetic machine network.
Compared with the prior art, the transcranial magnetic pulse interference filtering method, the transcranial magnetic pulse interference filtering system and the electronic equipment provided by the invention have the following advantages:
by adopting the adaptive filter, the training stage that the electric signal is zero is firstly carried out, the test object of a non-muscle object is utilized for training, the acquired electric signal is zero, the pulse interference signal and the electric signal can be effectively divided in the testing stage, the adaptive filter realizes the pertinence identification of the pulse interference signal in the magnetic stimulation, the pulse interference signal can be subjected to pertinence filtering in the actual work, and the acquisition of the electric signal cannot be influenced. Meanwhile, the scheme adopts the test object to enable the adaptive filter to carry out targeted identification on the electric signal, and the scheme is not a traditional frequency identification mode, so that excessive filtering on signal filtering can be reduced, and the filtering effect is improved. Furthermore, the scheme combines the iterative computation of the adaptive filtering and continuously updates the offset signal until the final result, so that the scheme can be close to completely filtering the interference signal and has high filtering efficiency.
In particular, according to an embodiment of the present disclosure, the processes described above with reference to the flowcharts may be implemented as computer software programs. For example, embodiments of the present disclosure include a computer program product comprising a computer program embodied on a computer readable medium, the computer program comprising program code for performing the method illustrated in the flow chart.
Which when executed by a processor performs the above-mentioned functions as defined in the method of the present application. It should be noted that the computer memory described herein may be a computer readable signal medium or a computer readable storage medium or any combination of the two. The computer memory may be, for example, but not limited to, an electronic, magnetic, optical, electromagnetic, infrared, or semiconductor system, apparatus, or device, or any combination of the foregoing.
More specific examples of computer memory may include, but are not limited to: an electrical connection having one or more wires, a portable computer diskette, a hard disk, a Random Access Memory (RAM), a read-only memory (ROM), an erasable programmable read-only memory (EPROM or flash memory), an optical fiber, a portable compact disc read-only memory (CD-ROM), an optical storage device, a magnetic storage device, or any suitable combination of the foregoing. In the present application, a computer readable signal medium may be any tangible medium that can contain, or store a program for use by or in connection with an instruction execution system, apparatus, or device. In this application, however, a computer readable signal medium may include a propagated data signal with computer readable program code embodied therein, for example, in baseband or as part of a carrier wave. Such a propagated data signal may take many forms, including, but not limited to, electro-magnetic, optical, or any suitable combination thereof. A computer readable signal medium may also be any computer readable medium that is not a computer readable storage medium and that can communicate, propagate, or transport a program for use by or in connection with an instruction execution system, apparatus, or device. Program code embodied on a computer readable medium may be transmitted using any appropriate medium, including but not limited to: wireless, wire, fiber optic cable, RF, etc., or any suitable combination of the foregoing.
Computer program code for carrying out operations for aspects of the present application may be written in any combination of one or more programming languages, including an object oriented programming language such as Java, Smalltalk, C + + or the like and conventional procedural programming languages, such as the "C" programming language or similar programming languages. The program code may execute entirely on the user's computer, partly on the user's computer, as a stand-alone software package, partly on the user's computer and partly on a remote computer or entirely on the remote computer or server. In the case of a remote computer, the remote computer may be connected to the user's computer through any type of network, including a Local Area Network (LAN) or a Wide Area Network (WAN), or the connection may be made to an external computer (for example, through the Internet using an Internet service provider).
The flowchart and block diagrams in the figures illustrate the architecture, functionality, and operation of possible implementations of systems, methods and computer program products according to various embodiments of the present application. In this regard, each block in the flowchart or block diagrams may represent a module, segment, or portion of code, which comprises one or more executable instructions for implementing the specified logical function(s). It should also be noted that, in some alternative implementations, the functions noted in the block may occur out of the order noted in the figures. For example, two blocks shown in succession may, in fact, be executed substantially concurrently, or the blocks may sometimes be executed in the reverse order, depending upon the functionality involved. It will also be noted that each block of the block diagrams and/or flowchart illustration, and combinations of blocks in the block diagrams and/or flowchart illustration, can be implemented by special purpose hardware-based systems which perform the specified functions or acts, or combinations of special purpose hardware and computer instructions.
The present invention is not limited to the above preferred embodiments, and any modifications, equivalent substitutions and improvements made within the spirit of the present invention should be included within the scope of the present invention.
Claims (6)
1. A transcranial magnetic pulse interference filtering method is characterized by comprising the following steps:
carrying out magnetic stimulation and electric signal acquisition on a test object, wherein a feedback signal of the test object to the electric signal acquisition is zero;
acquiring a magnetic stimulation signal and an electric signal based on the initial adaptive filter, and training the initial adaptive filter to obtain a final adaptive filter;
and based on the final adaptive filter, carrying out magnetic stimulation and electric signal acquisition on the designated part of the user.
2. The transcranial magnetic pulse interference filtering method according to claim 1, wherein: the training of the initial adaptive filter specifically comprises the following steps:
marking an initial moment based on a trigger signal of magnetic stimulation, wherein the magnetic stimulation has a pulse interference signal;
the initial adaptive filter sends out a corresponding cancellation signal from the initial moment based on the pulse interference signal;
and continuously updating the cancellation signal and the pulse interference signal by the initial adaptive filter, and merging the cancellation signal and the pulse interference signal until the cancellation signal and the pulse interference signal are completely cancelled to obtain the final adaptive filter.
3. The transcranial magnetic pulse interference filtering method according to claim 2, wherein: the process of updating the cancellation signal by the initial adaptive filter comprises the following steps:
the initial adaptive filter outputs a corresponding counteracting signal based on the received pulse interference signal;
and combining the offset signal and the pulse interference signal, judging whether a combination result is zero, if so, obtaining a final adaptive filter, and if not, repeating the steps.
4. The transcranial magnetic pulse interference filtering method according to claim 1, wherein: the steps of magnetic stimulation and electrical signal acquisition for a user specifically include:
stimulating the designated part of the user by a transcranial magnetic stimulation coil;
collecting an electric signal of a motion-induced potential of a stimulation part;
and (4) filtering the pulse interference signal by a final adaptive filter and then outputting a final muscle electric signal.
5. A transcranial magnetic pulse interference filtering system, characterized in that: the method comprises the following steps:
the test unit is used for carrying out magnetic stimulation and electric signal acquisition on a test object, and a feedback signal of the test object to the electric signal acquisition is zero;
the filtering identification unit is used for acquiring a magnetic stimulation signal and an electric signal based on the initial adaptive filter, training the initial adaptive filter and acquiring a final adaptive filter;
and the stimulation acquisition unit is used for carrying out magnetic stimulation and electric signal acquisition on the designated part of the user based on the final adaptive filter.
6. An electronic device comprising a memory and a processor, characterized in that: a computer program stored in the memory, the computer program being arranged to, when executed, perform the transcranial magnetic impulse interference filtering method of any one of claims 1-4;
the processor is arranged to execute the transcranial magnetic pulse interference filtering method of any one of claims 1 to 4 through the computer program.
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| CN116139409A (en) * | 2023-04-17 | 2023-05-23 | 江西朴拙医疗设备有限公司 | Anti-interference magnetic therapy detection system, threshold detection method and all-in-one machine |
| CN116510183A (en) * | 2023-06-28 | 2023-08-01 | 南昌大学第一附属医院 | Transcranial magnetic stimulation device, electronic device, and storage medium |
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