CN114917433A

CN114917433A - Lung-through drug administration atomization device

Info

Publication number: CN114917433A
Application number: CN202210492135.9A
Authority: CN
Inventors: 张建辉; 王嘉龙; 谭天; 谢堂; 温雨欣; 陈伯川; 梁家丽; 曾耀华
Original assignee: Guangzhou University
Current assignee: Guangzhou University
Priority date: 2022-05-07
Filing date: 2022-05-07
Publication date: 2022-08-19
Anticipated expiration: 2042-05-07
Also published as: CN114917433B

Abstract

The invention provides a pulmonary drug delivery atomization device, which relates to the technical field of atomizers and comprises: the base is filled with medium fluid; the ultrasonic transducer is fixed in the base and is coated by the medium fluid; the bottle body is detachably arranged on the base, the inside of the bottle body is filled with atomized fluid, and the outside of the bottle body is in contact with the medium fluid; the expansion cover body is provided with an expansion structure and is communicated with the interior of the bottle body in a sealing way. The high-frequency oscillation of the ultrasonic transducer is transmitted to the base by using the medium fluid, so that the connection structure of the atomizer is simplified, and the atomizer is convenient to transport and carry; the atomization fluid is directly atomized in the bottle body, so that the atomization process is simplified, and the atomization gas is more convenient to prepare; the pressure in the bottle can be adjusted at any time through the expanding cover body so as to adjust the spraying intensity, thereby ensuring better feeling during inhalation.

Description

Lung-through drug administration atomization device

Technical Field

The invention relates to the technical field of atomizers, in particular to a pulmonary drug delivery atomizing device.

Background

The atomizer is applied to more and more occasions in production and life of people. For example, in the medical field, when a new coronary pneumonia vaccine is inoculated or other respiratory diseases are treated, the injection mode is not friendly to the young or hemophilia patients, and the treatment can be carried out by atomizing the vaccine/medicament and then inhaling the atomized vaccine/medicament; in the field of daily life, electronic cigarettes gradually become a new trend to replace traditional cigarettes, and the electronic cigarettes are also atomizer devices for atomizing tobacco tar and then sucking the tobacco tar.

The principle of the atomizer on the market at present mainly is through porous atomizing net or high frequency mechanical oscillation, for example piezoceramics atomizing piece applys high frequency electronic oscillation, produces high frequency resonance through piezoceramics's adverse pressure effect and breaks up liquid molecular structure to form diameter nanometer level size water smoke, pour into the bottle into with its pressurization and use. The prior art mainly has the following problems:

firstly, a high-frequency oscillation device and an atomization container are required to be integrally connected and tightly contacted for excitation, so that the structural complexity and the space volume of the atomizer are increased, and the atomizer is inconvenient to transport and carry;

secondly, the liquid needs to be atomized and then the mist is filled into the bottle, so that the use is inconvenient;

and thirdly, along with the storage change of the atomized gas in the bottle, the pressure in the bottle changes along with the storage change, the spraying strength is too high when the atomized gas is too much, and the spraying strength is too low when the atomized gas is too little, so that the inhalation discomfort is caused.

Disclosure of Invention

The invention aims to provide a pulmonary drug delivery atomization device which can enhance the portability of an atomizer, is convenient to use and has controllable spray intensity;

the invention provides a pulmonary delivery atomization device, comprising: the base is filled with medium fluid; the ultrasonic transducer is fixed in the base and is coated by the medium fluid; the bottle body is detachably arranged on the base, contains atomized fluid inside and is in contact with the medium fluid outside; the expansion cover body is provided with an expansion structure and is communicated with the interior of the bottle body in a sealing way.

Further, the cover body that contracts that expands includes flexible spine and open-close plate, open-close plate's one end with pass through between the bottle flexible spine rotates to be connected, open-close plate's side with connect through the spring page or leaf between the bottle.

Furthermore, the flexible ridge is provided with an insertion hole, the insertion hole is connected with a sealing sheet, and the sealing sheet is used for keeping sealing after the insertion hole is inserted.

Further, still include the syringe, the syringe can insert injection the atomizing fluid in the jack.

Further, the portable fog collector also comprises a fog absorber, and the fog absorber can be inserted into the insertion hole and used for absorbing fog of a user.

Further, the opening plate and the bottle body are connected through a rolling curtain device, and the rolling curtain device is used for controlling the opening plate to roll around the flexible ridge to turn over.

Further, be equipped with pressure sensor in the bottle, roll up the curtain device and include motor and control system, pressure sensor with the motor all with control system connects.

Furthermore, be equipped with the hook groove on the division board, be connected with the drag hook on the motor, the drag hook carry be in on the hook groove.

Further, be equipped with a plurality of on the base the bottle.

Further, the base comprises a containing groove, the ultrasonic transducer is fixed at the bottom of the containing groove, the medium fluid is contained in the containing groove, and a flange for bearing the bottle body is arranged on the inner wall of the containing groove.

According to the technical scheme, the high-frequency oscillation of the ultrasonic transducer is transmitted to the base by using the medium fluid, so that the connection structure of the atomizer is simplified, and the atomizer is convenient to transport and carry; the atomization fluid is directly atomized in the bottle body, so that the atomization process is simplified, and the atomization gas is more convenient to prepare; the pressure intensity in the bottle can be adjusted at any time through the expansion cover body so as to adjust the spraying intensity, thereby leading the feeling to be better when the bottle is sucked.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, and it is obvious that the drawings in the following description are some embodiments of the present invention, and other drawings can be obtained by those skilled in the art without creative efforts.

FIG. 1 is a schematic diagram of the pre-atomization state of the present invention;

FIG. 2 is a schematic view of the state during atomization according to the present invention;

FIG. 3 is a schematic diagram of the post-atomization state of the present invention;

FIG. 4 is a schematic representation of the fluid state of the injection medium prior to atomization in accordance with the present invention;

FIG. 5 is a schematic view of the atomized particles inhaled after atomization according to the invention;

FIG. 6 is a schematic view of the retractable cover of the present invention;

FIG. 7 is a schematic view of the expanded cover body according to the present invention;

FIG. 8 is a schematic view of the position of the pressure sensor of the present invention;

description of reference numerals:

1-base, 101-flange

2-ultrasonic transducer, 3-bottle

4-expansion cover body, 401-flexible ridge, 402-opening plate, 403-spring leaf and 404-sealing plate

5-a medium fluid,

6-atomizing fluid, 601-atomizing particles

7-injector, 8-mist absorber

9-rolling curtain device, 901-pressure sensor, 902-drag hook and 903-hook groove

Detailed Description

The technical solutions of the present invention will be described clearly and completely with reference to the following embodiments, and it should be understood that the described embodiments are some, but not all, embodiments of the present invention. All other embodiments, which can be obtained by a person skilled in the art without making any creative effort based on the embodiments in the present invention, belong to the protection scope of the present invention.

In the description of the present invention, it is to be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", and the like, indicate orientations and positional relationships based on those shown in the drawings, and are used only for convenience of description and simplicity of description, and do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, should not be considered as limiting the present invention.

Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, features defined as "first" and "second" may explicitly or implicitly include one or more of the described features. In the description of the present invention, "a plurality" means two or more unless specifically defined otherwise. Furthermore, the terms "mounted," "connected," and "coupled" are to be construed broadly and may include, for example, fixed connections, removable connections, or integral connections; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.

Example 1

Specifically, this example 1 will be described with reference to pulmonary inhalation of a new corona vaccine.

As shown in fig. 1-3, the present invention provides a pulmonary delivery aerosolization device comprising: the device comprises a base 1, wherein medium fluid 5 is contained in the base 1; an ultrasonic transducer 2 fixed in the base 1 and covered with a dielectric fluid 5; the bottle body 3 is detachably arranged on the base 1, the inside of the bottle body is filled with atomized fluid 6, and the outside of the bottle body is in contact with medium fluid 5; a telescopic cover 4 having a telescopic structure and hermetically communicating with the interior of the bottle 3.

The initial stage in the preparation of the atomizer is shown in figure 1. The ultrasonic transducer 2 is fixed on the base 1, and a proper amount of medium fluid 5 is filled in the base 1. Because the dielectric fluid 5 needs to transmit the mechanical energy generated by the ultrasonic transducer 2, the liquid level of the dielectric fluid 5 is at least higher than that of the new corona vaccine in the bottle body 3 while completely submerging the ultrasonic transducer 2. The bottle bodies 3 are placed on the base 1, and a retainer can be added to the base 1 to relatively fix the positions of the bottle bodies 3 and prevent the bottle bodies from floating, floating or falling. After the bottle body 3 is placed, the power supply of the ultrasonic transducer 2 can be switched on to start atomization;

in the operating phase of the atomizer, this is shown in fig. 2. The ultrasonic transducer 2 generates vibration after being powered on, and the vibration is transmitted to the bottle body 3 through the medium fluid 5, so that the new corona vaccine in the bottle body 3 is atomized to form atomized particles 601. Along with the quantity of the atomized particles 601 continuously increases, the pressure in the bottle rises, and the expansion cover body 4 expands along with the pressure, so that the pressure in the bottle body 3 is kept stable, the phenomenon that the flow is too large when the atomized particles 601 are inhaled is avoided, the atomized particles 601 are uniformly distributed in the bottle body 3, the problem that the atomized particles 601 are mainly concentrated at the bottom in the atomization device with unchangeable volume can be avoided, and the atomization efficiency is effectively improved. When the new corona vaccine in the bottle is completely atomized, the power supply of the ultrasonic transducer 2 is cut off to form a state shown in figure 3, and the atomization process is finished.

In the present invention, the body 3 should have a good ability to transmit vibration; the cross-sectional shape of the body 3 includes, but is not limited to, a circle, an ellipse, a polygon or other fitting shape that facilitates transmission of vibration, etc.; the material of the bottle body 3 includes, but is not limited to, plastic, metal, glass, etc. The bottle body 3 is stably placed on the base 1 or fixed on the base 1 through a fastening device; the level of the atomized fluid 6 in the bottle 3 should always be equal to or lower than the level of the dielectric fluid 5 in the base 1.

In the present invention, the medium fluid 5 should have the function of transferring the mechanical energy generated by the ultrasonic transducer 2 and transmitting the mechanical energy to the bottle 3. Including but not limited to water and organic solvents such as alcohols, ethers, esters, ketones, and the like, and specifically, any one of a viscous semisolid preparation made of purified water, medical alcohol, a sodium alginate solution, a sodium carboxymethyl cellulose solution, a carbomer solution, glycerin, and a viscous semisolid preparation made of propylene glycol can be selected.

In the present invention, the ultrasonic transducer 2 is connected to an external power source and rigidly connected to the base 1, and the connection method is preferably glue bonding, including but not limited to glue bonding, welding, embedding, integral molding, etc. The ultrasonic transducer 2 includes, but is not limited to, a piezoelectric type ultrasonic transducer 2. Piezoelectric type ultrasonic transducer 2 applys the high frequency electron vibration to piezoceramics atomizing piece, produces high frequency resonance through piezoceramics's adverse pressure effect and breaks up liquid molecular structure to form the water smoke of diameter nanometer grade size, can be effectively in the air of diffusing to liquid medicine or essential oil etc. the prior art finished product that this kind of ultrasonic transducer 2 belongs to and purchases, no longer gives unnecessary details.

In the present invention, the function of the expanding and contracting cap 4 is mainly to make the volume space of the bottle body 3 variable. Can be realized by a foldable structure (such as a corrugated pipe, a folding plate and the like), or by a telescopic structure (such as a telescopic plate which can be drawn and stretched and the like), or by the characteristics of the material (such as an elastic rubber film and the like), and the description is omitted. When the bottle body 3 is connected with the expandable cover body 4, a sealing gasket can be arranged.

In the present invention, the new crown vaccine is exemplified as the atomized fluid 6, but it should be noted that the atomized fluid 6 may be various liquid substances to be atomized, such as inhalation vaccines, inhalation drugs, electronic cigarette oil, aromatic essential oil, coffee essential oil, alcohol, etc.; and may contain fluids that aid atomization, such as low viscosity fluids, organic solvents, and the like.

Example 2

Specifically, the present embodiment 2 provides a specific structure of the expanding and contracting cover 4.

As shown in fig. 4-7, the retractable cover 4 includes a flexible ridge 401 and a snap plate 402, one end of the snap plate 402 is rotatably connected to the bottle 3 through the flexible ridge 401, and the side of the snap plate 402 is connected to the bottle 3 through a spring leaf 403.

The flexible ridge 401 is specifically a connecting sheet with resilience capability, such as a flexible plastic sheet, which is located at one end of the top opening of the bottle body 3 and is connected with the bottle body 3 in a sealing manner, and one end of the opening plate 402 is connected with the flexible ridge 401 in a sealing manner, that is, the flexible ridge 401 is connected with the opening plate 402 and the bottle body 3 into a whole, the connection manner includes and is not limited to bonding, thermoplastic, punch forming connection and other connection manners, the side end of the spring leaf 403 is embedded in the inner side of the flexible ridge 401, and the airtightness of the atomization bottle can be ensured at the position by dropping solid soluble polymers such as EVA hot melt adhesive and the like. The other end of the opening-closing plate 402 can be turned around the flexible ridge 401 (the maximum rotation angle is preferably 90 degrees) due to the resilience of the flexible ridge 401, and the spring leaf 403 expands or retracts along with the flexible ridge 401 during the turning process of the opening-closing plate 402, so that the expansion-contraction cover 4 has the expansion-contraction function, and the volume of the bottle body 3 is adjusted. The spring leaf 403 comprises a foldable structure formed by a plurality of blades, and can be changed in a telescopic way, the telescopic path is a section of circular arc, and the telescopic path and the opening plate 402 mutually keep a certain coaxiality, and the spring leaf and the bottle body 3 continuously keep stable in relative position when being changed in a telescopic way. The specific number of blades includes, and is not limited to, ten layers; the material is plastic, and the material selection includes but is not limited to plastic, rubber, paper and the like, and mainly can play a sealing effect.

Example 3

Specifically, in embodiment 3, the mist suction structure of the mist suction device 8 is described.

As shown in fig. 4-5, the flexible ridge 401 has an insertion hole (not shown) therein, and a sealing plate 404 is connected to the insertion hole, and the sealing plate 404 is used for maintaining a seal after the insertion hole is inserted. A syringe 7 is also included, the syringe 7 being insertable into the socket for injection of the atomised fluid 6. Also comprises a mist absorber 8, and the mist absorber 8 can be inserted into the jack for absorbing mist of a user.

After the atomization is completed, the bottle body 3 is removed from the base 1, as shown in fig. 7, and the spring leaf 403 is in an expanded state, and the bottle is filled with the new corona vaccine atomized particles 601. The atomized particles 601 in the bottle 3 naturally have a lower concentration at the upper layer and a higher concentration at the lower layer due to gravity, but the whole bottle 3 is filled. The atomizing bottle after atomization can be used immediately, and can also be used in other time and occasions after refrigeration and transportation. When in use, the inside of the bottle body 3 exchanges materials with the outside through the jack. The sealing sheet 404 is arranged on the jack in a sealing way, and before atomization, the injector 7 is inserted into the sealing sheet 404 to inject the atomized fluid 6 into the bottle body 3; in the atomization process, the sealing sheet 404 is pulled out, and the sealing sheet 404 is closed again to keep a sealed environment in the bottle body 3; after the atomization is completed, the mist sucker 8 is inserted into the sealing sheet 404 to suck the atomized particles 601. The material of the sealing sheet 404 includes, but is not limited to, plastic, metal, paper, and the like, and can be brought into close contact with the syringe 7 and the mist absorber 8 after insertion, thereby maintaining the sealing property. Sealing disc 404 is attached to flexible ridge 401 and provides a good seal, including but not limited to adhesive, thermoplastic, stamped and formed attachment, and the like. The mist inhaler 8 specifically comprises a cannula for insertion into the sealing disc 404 and a mist mask for mist inhalation by the user.

The process of inoculating the new corona vaccine is shown in fig. 7, after the sealing sheet 404 is opened by the fog absorber 8, the opening plate 402 is pressed to turn downwards, in the process of turning downwards, the spring leaf 403 contracts, the gas pressure in the bottle is increased, the new corona vaccine atomized particles 601 are sprayed out from the fog-absorbing mask, and then the new corona vaccine atomized particles 601 enter the lungs of the inoculated person, so that the inoculation process is completed. Through the speed that control opening plate 402 pushed down, can control new crown bacterin atomized particles 601 spun flow, even bottle 3 has used more firm hard material, also can easily make in the bottle new crown bacterin atomized particles 601 a large amount of, discharge bottle 3 evenly.

When the opening plate 402 is turned back down to 0 degrees, the inoculation process is complete. At this time, the shape of the expansion/contraction cap 4 is as shown in fig. 6, the space in the bottle becomes minimum, and most of the atomized particles 601 are discharged. Inhale fog face guard and abandon according to medical waste as disposable product, bottle 3 and the structure of the body of the lid 4 that contracts of expanding can be recycled after retrieving, but base 1 and ultrasonic transducer 2 direct used repeatedly. The whole repeatable utilization rate is high, and the cleaning and the environmental protection are realized.

Example 4

Specifically, embodiment 4 describes a control structure of the expansion/contraction cover body 4.

As shown in fig. 4-8, the opening plate 402 is connected with the bottle bodies 3 through a roller shutter device 9, and the roller shutter device 9 is used for controlling the opening plate 402 to turn around the flexible ridge 401. The bottle body 3 is internally provided with a pressure sensor 901, the roller shutter device 9 comprises a motor (not shown) and a control system (not shown), and the pressure sensor 901 and the motor are both connected with the control system. The opening plate 402 is provided with a hook groove 903, the motor is connected with a draw hook 902, and the draw hook 902 is hung on the hook groove 903.

In the atomization process, the pressure sensor 901 detects that the pressure in the bottle body 3 is greater than a set value, namely, an electric signal is transmitted to the control system, the control system receives the signal and then controls the motor to act, so that the motor recovers the drag hook 902, the drag hook 902 pulls the opening plate 402 to turn upwards through the hook groove 903 which is embedded with the drag hook 902, and the spring leaf 403 stretches and expands along with the opening plate, so that the telescopic cover body 4 expands, the capacity of the atomization bottle formed by the telescopic cover body 4 and the bottle body 3 is increased until the pressure reaches a preset value. Otherwise, the pressure sensor 901 detects that the pressure inside the bottle body 3 is smaller than the set value, and the motor releases the draw hook 902, so that the telescopic cover body 4 is contracted, and the capacity of the atomization bottle formed by the telescopic cover body 4 and the bottle body 3 is reduced until the pressure reaches the preset value.

In order to reduce the cost of use, the roller blind device 9 can be removed when the bottle 3 needs to be sterilized or replaced, and can be mounted on the sterilized bottle 3 or another fresh bottle 3 which is not used, and mounted and connected with a new opening plate 402. The motor can be externally connected with a power supply or provided with a battery system for supplying power.

Example 5

Specifically, for example, in the field of electronic cigarette atomization, multiple raw materials are often required to be atomized and mixed to manufacture electronic cigarette products with different tastes, and a single atomizer can only add one liquid to be atomized at the same time, and cannot atomize multiple liquids with different components at the same time, which causes inconvenience. In embodiment 5, the structure for atomizing a plurality of vials 3 at the same time will be described.

A plurality of bottle bodies 3 are arranged on the base 1. Base 1 includes the holding tank, and ultrasonic transducer 2 fixes in the bottom of holding tank, and medium fluid 5 holds in the holding tank, is equipped with the flange 101 that bears bottle 3 on the inner wall of holding tank.

Take the example of electron smog process, inject into different bottle 3 respectively with various different raw materials earlier in, then these bottles 3 place on base 1 jointly, because this device carries out the vibration transmission through medium fluid 5, so need not set up other connection structure in order to realize the vibration, reduced manufacturing cost. After the ultrasonic transducer 2 is opened, different atomized fluids 6 in all the bottle bodies 3 on the base 1 are atomized synchronously, and atomized particles 601 in all the bottle bodies 3 are mixed and inhaled after atomization, so that the electronic cigarette with mixed taste can be achieved. The supply speed of the atomized particles 601 of each raw material can be individually controlled by individually controlling the turning degree of the opening plate 402 on the different bottle bodies 3, thereby adjusting the flavors of the mixed atomized particles 601.

The use principle of the invention is as follows:

when the ultrasonic atomization device is required to be used, the fluid 6 to be atomized is prestored in the bottle body 3 or the fluid 6 to be atomized is injected into the bottle body 3 through the injector 7, the bottle body 3 is placed on the base 1 to be in contact with the medium fluid 5, the ultrasonic transducer 2 is started, and the medium fluid 5 transmits vibration energy to atomize. The volume inside the bottle body 3 is controlled by the expansion of the expansion cover body 4 in the atomization process; after the atomization is completed, the fog absorber 8 is used for inserting the sealing sheet 404 to absorb fog, and the spraying force of the atomized particles 601 can be controlled by pressing the opening and closing plate 402.

Other advantages of the invention:

the fluid 6 to be atomized can be packaged in the bottle body 3 before atomization, so that the transportation and the storage are convenient; or the fluid 6 to be atomized is injected into the bottle 3 through the injector 7, and the controllability is higher.

The mist output amount can be adjusted by changing the expansion and contraction of the expansion and contraction cover body 4; during atomization, due to the telescopic change of the spring leaf 403, the air pressure in the bottle body 3 is always in a dynamic and stable state, the volume in the bottle body 3 is increased from small to small, the density gradient distribution of the atomized particles 601 is also uniform, and the layering effect that the lower layer has fog and the upper layer has no fog is avoided.

During atomization, a plurality of bottle bodies 3 can be placed on one base 1 at the same time, and various liquids with different components can be atomized in different bottles at the same time, so that a plurality of bottles of fog are produced at the same time, and the atomization efficiency is greatly improved; after atomization, single bottle packaging is carried out, so that the atomizing quality is not influenced by the environment; each bottle of mist is independently subpackaged, and different bottles are supplied for different users to use, so that the bottle is clean and sanitary.

When the opening plate 402 is pressed down, the spring leaf 403 is driven to contract, the mist is sprayed out of the mist absorber 8 through air pressure increase, the process that a user sucks air forcibly is omitted, the mist in the bottle body 3 can be discharged more fully after being compressed, and waste of residual mist is reduced.

Finally, it should be noted that: the above embodiments are only used to illustrate the technical solution of the present invention, and not to limit the same; while the invention has been described in detail and with reference to the foregoing embodiments, it will be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; and the modifications or the substitutions do not make the essence of the corresponding technical solutions depart from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. A pulmonary delivery aerosolization apparatus, comprising:

the base is filled with medium fluid;

the ultrasonic transducer is fixed in the base and is coated by the medium fluid;

the bottle body is detachably arranged on the base, the inside of the bottle body is filled with atomized fluid, and the outside of the bottle body is in contact with the medium fluid;

the expansion cover body is provided with an expansion structure and is communicated with the interior of the bottle body in a sealing way.

2. The aerosolization device for transpulmonary administration of a drug as claimed in claim 1, wherein the retractable cover comprises a flexible ridge and an opening plate, wherein one end of the opening plate is rotatably connected to the vial body via the flexible ridge, and wherein a side surface of the opening plate is connected to the vial body via a spring leaf.

3. The aerosolization apparatus for transpulmonary administration of claim 2, wherein the flexible ridge defines a receptacle, and wherein a sealing plate is coupled to the receptacle and configured to maintain a seal after the receptacle is inserted.

4. The pulmonary delivery aerosolization device of claim 3 further comprising a syringe insertable into the receptacle for injection of the aerosolized fluid.

5. The aerosolization apparatus for transpulmonary administration of a drug according to claim 3, further comprising a mist inhaler insertable into the receptacle for inhalation by a user.

6. The aerosolization device for transpulmonary administration of a drug according to claim 2, wherein the opening plate is coupled to the vial body via a roller shutter mechanism for controlling the opening plate to rotate about the flexible spine.

7. The atomizing device for transpulmonary administration of claim 6, wherein a pressure sensor is disposed in the bottle body, the rolling shutter device comprises a motor and a control system, and both the pressure sensor and the motor are connected to the control system.

8. The atomization device for pulmonary drug delivery according to claim 7, wherein the opening plate is provided with a hook groove, the motor is connected with a drag hook, and the drag hook is hung on the hook groove.

9. The aerosolization device for transpulmonary administration of a drug as in claim 1, wherein the base comprises a plurality of the vials.

10. The aerosolization apparatus for transpulmonary administration of claim 9, wherein the base comprises a receiving cavity, the ultrasound transducer is secured to a bottom of the receiving cavity, the medium fluid is received in the receiving cavity, and a flange is disposed on an inner wall of the receiving cavity for supporting the vial.