CN114903869B - Bead blasting nursing liquid, production process and intelligent production equipment - Google Patents

Bead blasting nursing liquid, production process and intelligent production equipment Download PDF

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CN114903869B
CN114903869B CN202210527756.6A CN202210527756A CN114903869B CN 114903869 B CN114903869 B CN 114903869B CN 202210527756 A CN202210527756 A CN 202210527756A CN 114903869 B CN114903869 B CN 114903869B
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bead
explosion
liquid
beads
explosive
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CN114903869A (en
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郭利坤
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Guangzhou Orange Innovation Technology Co ltd
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Guangzhou Orange Innovation Technology Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B11/00—Measuring arrangements characterised by the use of optical techniques
    • G01B11/08—Measuring arrangements characterised by the use of optical techniques for measuring diameters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
    • G01F17/00—Methods or apparatus for determining the capacity of containers or cavities, or the volume of solid bodies
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
    • G01F22/00—Methods or apparatus for measuring volume of fluids or fluent solid material, not otherwise provided for
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01G—WEIGHING
    • G01G17/00—Apparatus for or methods of weighing material of special form or property
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

The invention belongs to the technical field of bead blasting, and particularly relates to a nursing liquid bead blasting, a production process and intelligent production equipment. The nursing liquid explosion bead comprises an explosion bead content liquid and an explosion bead wall material glue liquid, and the explosion bead content liquid comprises: the blumea balsamifera extract comprises blumea balsamifera extract, a cosolvent, a bacteriostat and a solvent, wherein the cosolvent is polyoxyethylene hydrogenated castor oil, the solvent is 15-30% ethanol, and the mass fraction of the blumea balsamifera extract is 0.2-1% based on the mass of the explosive bead content liquid; the bead wall glue solution comprises acacia, glycerol, lemon yellow and acetate starch. According to the invention, blumea balsamifera extract, a cosolvent, a bacteriostat and a solvent are used as main components of the explosive bead content liquid, and acacia gum is used as main components of the explosive bead wall glue liquid, so that bacterial growth in the oral cavity of a user can be inhibited, and the oral cavity can be treated obviously, and has obvious treatment effects on gingivitis, periodontitis and gingival bleeding, especially on patients with canker sores, and normal oral cavity microbial flora can be maintained, so that oral health is ensured.

Description

Bead blasting nursing liquid, production process and intelligent production equipment
Technical Field
The invention belongs to the technical field of bursting beads, and particularly relates to a nursing liquid bursting bead, a production process and intelligent production equipment.
Background
The bursting beads, also called perfume pellets, friable capsules, beads, are breakable beads, which have a bursting sensation when broken. The prior art explosive beads are generally applied to cigarettes.
With the development of social economy, people pay more attention to oral health, and the oral cavity and the throat are channels for eating and breathing, are also necessary routes for dietary water to enter a human body, and are closely related to the health and survival of the human body. Therefore, the health of the oral cavity has important influence on human bodies, bacterial and virus infection, air pollution, excessive sound consumption, pungent dryness-heat stimulation of food and other factors are easy to cause oral cavity problems, and periodontitis, canker sore and the like are easy to develop if the oral cavity problems are solved by the oral cavity problems; the canker sore is usually found on the lingual surface, lips, gums, etc. The oral ulcer is severe in pain during the onset, the local burning pain is obvious, the serious people can influence diet and speaking, bad breath, chronic pharyngitis and the like can also be complicated, and if the oral ulcer is not treated in time, great inconvenience is caused to daily life.
In the prior art, aiming at the treatment of oral diseases, a spray medicine is generally selected to spray a lesion part in an oral cavity or a patient takes oral pills, and as the patient can not accurately judge the accurate position of the lesion part in the oral cavity, the patient can not spray the medicine to a target position when holding the spray medicine, so that the treatment of the oral diseases is influenced; the pill medicines have the problems of slow dissolution, easy mistaking, and the like, and are difficult to meet the requirements of patients on rapid treatment of oral diseases.
Disclosure of Invention
The technical scheme of the present invention has been proposed in view of the above problems. The invention provides a nursing liquid bursting bead, a production process and intelligent production equipment, which are used for solving the problems that in the prior art, aiming at the treatment of oral diseases, a spray medicine is generally selected to spray a lesion part in an oral cavity or a patient takes pills, and the patient cannot spray the medicine to a target position when holding the spray medicine because the patient cannot accurately judge the accurate position of the lesion part in the oral cavity, so that the treatment of the oral diseases is influenced; the pill medicines have the problems of slow dissolution, easy mistaking, and the like, and also have the technical problem of difficult meeting the requirements of patients on the rapid treatment of oral diseases.
The invention is realized by adopting the following technical scheme:
the nursing liquid bursting beads comprise bursting bead content liquid and bursting bead wall material glue liquid, and the mass ratio of the bursting bead content liquid to the bursting bead wall material glue liquid is 100: (1-3), wherein:
the explosive bead content liquid comprises: the blumea balsamifera extract comprises blumea balsamifera extract, a cosolvent, a bacteriostat and a solvent, wherein the cosolvent is polyoxyethylene hydrogenated castor oil, the solvent is 15-30% ethanol, and the mass fraction of the blumea balsamifera extract is 0.2-1% based on the mass of the explosive bead content liquid;
The bead wall glue solution comprises acacia, glycerol, lemon yellow and acetate starch.
As a further scheme of the invention, the mass fraction of the solvent is 0.1-0.5% based on the mass of the content liquid of the explosion beads.
As a still further scheme of the invention, the mass fraction of the bacteriostatic agent is 0.2-0.8% based on the mass of the content liquid of the explosion beads.
As a still further scheme of the invention, the bacteriostatic agent is A.SAP or ornidazole stock solution.
As a still further scheme of the invention, the mass ratio of the acacia, the glycerin, the lemon yellow and the acetate starch is as follows: 100:80:5:20.
A production process of a nursing liquid explosion bead comprises the following steps:
step one, preparing a bead explosion content liquid: adding solvent into blumea balsamifera extract and cosolvent, stirring until the extract and the cosolvent are dissolved uniformly, adding antibacterial agent, continuously stirring for 30-45 min, standing, and filtering to obtain a bursting bead content liquid;
step two, preparing a bead explosion wall material glue solution: mixing acetate starch and half of glycerol, grinding by a grinder, filtering to obtain a mixture, adding the mixture, lemon yellow and the rest glycerol into a mixing reaction kettle, stirring, adding acacia to uniform glue solution while stirring, stopping stirring, standing, vacuumizing to a vacuum degree of-0.05 to-0.1 Mpa, and degassing for 1-1.5 hours until the glue solution has no bubbles, thus obtaining the explosion bead wall glue solution;
Thirdly, circulating the explosion bead wall material glue solution under the action of a magnetic stirrer, dripping the explosion bead content solution into the flowing explosion bead wall material glue solution by utilizing three-phase flow pill dropping equipment, dripping the explosion bead content solution into the explosion bead wall material glue solution to form a sphere, growing until the coating reaches the thickness requirement, removing forming liquid or floccules on the surface of the explosion bead by using slow flowing water, and collecting and fishing out the explosion bead in a wet state;
and fourthly, putting the explosion beads in a wet state into drying equipment for drying, and putting the dried explosion beads into a drying room in a temperature and humidity balance environment for standing until the water content reaches the requirement of the explosion beads of the finished product.
In a still further aspect of the present invention, in the first step, the preparation method of the blumea balsamifera extract comprises: and (3) carrying out steam distillation on blumea balsamifera to obtain volatile oil, filtrate and medicinal residues respectively, drying the filtrate to obtain a first extract, extracting, concentrating and extracting the medicinal residues to obtain a second extract, and mixing the volatile oil, the first extract and the second extract to obtain the blumea balsamifera extract.
As a still further scheme of the invention, the invention also comprises a method for detecting the finished product explosive beads, and the method comprises the following steps:
a. Measuring a bead explosion parameter of the bead explosion through detection equipment, wherein the bead explosion parameter comprises the mass and the volume of the bead explosion, the mass and the volume of a bead explosion content liquid and the mass and the volume of a bead explosion wall material glue liquid;
b. setting a threshold value of the bead explosion parameter, and comparing the threshold value with the measured bead explosion parameter to obtain a comparison result;
c. judging whether the produced explosive beads are qualified or not according to the comparison result, and when the produced explosive beads are unqualified, readjusting the process parameters until the produced explosive beads reach the requirements, so that the condition that the explosive beads are not broken and unmatched when being put on a production line is ensured.
The utility model provides an intelligent production equipment of pearl is exploded to nursing liquid, includes three-phase flow pill equipment, carries out quality detection's check out test set to the fashioned pearl that explodes of dripping and carries out the drying equipment that moisture was got rid of to the post-forming pearl that explodes, drying equipment includes:
the inner wall of the first cylinder is provided with a water inlet cavity for liquid cleaning agent to enter and a water outlet cavity for liquid cleaning agent to be discharged, and the water inlet cavity and the water outlet cavity are communicated with a cavity formed in the first cylinder;
the second cylinder body is rotatably arranged in the first cylinder body, and two ends of the second cylinder body extend out of the first cylinder body and extend to form a feeding section for the explosive beads to enter and a discharging section for the explosive beads to discharge; the second cylinder is positioned in the first cylinder, and a plurality of through holes for liquid cleaning agent to enter the second cylinder are circumferentially formed in the cylinder wall of the second cylinder, so that the liquid cleaning agent enters the second cylinder to clean the formed explosion beads in the second cylinder; the second cylinder is internally provided with a push plate for pushing the formed explosive beads to move and a push rod for driving the push plate to slide in the second cylinder, and the push rod is controlled to drive the push plate to move so that the push plate pushes the formed explosive beads in the second cylinder to move from a feeding section to a discharging section;
The drying pipe is communicated with the blanking section and comprises an annular side wall and a drying channel surrounded by the annular side wall, the annular side wall comprises an inner wall, an outer wall and a heating cavity formed between the inner wall and the outer wall, a plurality of air holes are formed in the inner wall, hot air introduced into the heating cavity passes through the air holes to enter the drying channel, and wet forming explosion beads moving in the drying channel are dried.
Further, at least one liquid inlet is formed in the upper side of the first barrel, the liquid inlet is communicated with the water inlet cavity, at least one liquid outlet is formed in the lower side of the first barrel, the liquid outlet is communicated with the water outlet cavity, liquid cleaning agent (water or cleaning liquid) for cleaning formed explosion beads is introduced into the water inlet cavity from the liquid inlet, sprayed to the second barrel through the water inlet cavity, formed explosion beads in the second barrel are cleaned, waste water after cleaning is collected and enters the water outlet cavity, and then discharged from the liquid outlet;
still further still, still include control the rotatory actuating mechanism of second barrel, actuating mechanism includes pivot, fixed mounting in epaxial gear and the ring gear of fixed mounting on the second barrel, the gear with the ring gear meshing drives the pivot is rotatory, drives ring gear and second barrel through the gear and rotates.
As still further aspects of the present invention, the detecting apparatus includes:
the image acquisition module is used for acquiring an original image formed by the bead blasting drip;
the image processing module is used for fitting the original image to form a processing image, wherein the processing image comprises a bead blasting wall material glue solution image and a bead blasting content liquid image; is also used for obtaining the diameter D of the explosive bead content liquid based on the explosive bead wall material glue liquid image and the explosive bead content liquid image 1 Diameter D of explosion bead wall glue solution 2 ；
The data analysis module is used for acquiring known data and detection data, wherein the known data comprise the density of the explosive bead content liquid and the density of the explosive bead wall glue liquid which are input by a user, and the detection data comprise the diameter of the explosive bead content liquid and the diameter of the explosive bead wall glue liquid; and is also used for calculating the bead blasting parameters according to the known data and the detection data.
Further, the bursting bead parameters comprise the mass and the volume of bursting beads, the mass and the volume of bursting bead content liquid and the mass and the volume of bursting bead wall glue liquid, wherein:
the mass of the content liquid of the explosion beads
Figure BDA0003645019540000041
Explosion bead content volume->
Figure BDA0003645019540000042
The mass of the glue solution of the explosion wall material>
Figure BDA0003645019540000043
Volume of glue solution for explosion wall material
Figure BDA0003645019540000044
Explosive bead volume->
Figure BDA0003645019540000045
Mass m of explosion bead 3 ＝m 1 +m 2 Wherein:
D 1 diameter of content liquid of explosive beads D 2 Is the diameter ρ of the glue solution of the explosion bead wall material 1 For the density of the content liquid of the explosive beads, ρ 2 For explosionBead wall glue density.
The technical scheme provided by the invention has the following beneficial effects: according to the invention, blumea balsamifera extract, a cosolvent, a bacteriostat and a solvent are used as main components of the explosive bead content liquid, and acacia gum is used as main components of the explosive bead wall glue liquid, so that bacterial growth in the oral cavity of a user can be inhibited, and the oral cavity can be treated obviously, and has obvious treatment effects on gingivitis, periodontitis and gingival bleeding, especially on patients with canker sores, and normal oral cavity microbial flora can be maintained, so that oral health is ensured.
Drawings
The accompanying drawings are included to provide a further understanding of the invention and are incorporated in and constitute a part of this specification, illustrate the invention and together with the embodiments of the invention, serve to explain the invention. In the drawings:
fig. 1 is a flow chart of a production process of the nursing liquid blasting beads.
Fig. 2 is a schematic structural diagram of a drying device in an intelligent production device for blasting beads with a care solution.
Fig. 3 is a cross-sectional view of a drying device in an intelligent production device for bursting beads of a care solution.
Fig. 4 is a schematic diagram of a first cylinder and a second cylinder of an intelligent production device for blasting beads with a care solution.
Fig. 5 is a block diagram of a detection device in an intelligent production device for the beads of the nursing liquid.
In the figure: 100-first cylinder, 110-liquid inlet, 120-liquid outlet, 130-side plate, 140-water inlet cavity, 150-water outlet cavity, 200-second cylinder, 210-feed inlet, 220-push rod, 230-push plate, 240-feed inlet, 250-through hole, 300-driving mechanism, 310-rotating shaft, 320-gear, 330-gear ring, 400-drying tube, 500-image acquisition module, 600-image processing module and 700-data analysis module.
Detailed Description
The present invention will be described in further detail with reference to the drawings and examples, in order to make the objects, technical solutions and advantages of the present invention more apparent. It should be understood that the specific embodiments described herein are for purposes of illustration only and are not intended to limit the scope of the invention.
It is noted that various aspects of the embodiments are described below within the scope of the following claims. It should be apparent that the aspects described herein may be embodied in a wide variety of forms and that any specific structure and/or function described herein is merely illustrative. Based on the present disclosure, one skilled in the art will appreciate that one aspect described herein may be implemented independently of any other aspect, and that two or more of these aspects may be combined in various ways. For example, an apparatus may be implemented and/or a method practiced using any number of the aspects set forth herein. In addition, such apparatus may be implemented and/or such methods practiced using other structure and/or functionality in addition to one or more of the aspects set forth herein.
It should be understood that although the terms first, second, etc. may be used in embodiments of the present invention to describe various information, these information should not be limited by these terms. These terms are only used to distinguish one type of information from another.
With the development of social economy, people pay more attention to oral health, and the oral cavity and the throat are channels for eating and breathing, are also necessary routes for dietary water to enter a human body, and are closely related to the health and survival of the human body. Therefore, the health of the oral cavity has important influence on human bodies, bacterial and virus infection, air pollution, excessive sound consumption, pungent dryness-heat stimulation of food and other factors are easy to cause oral cavity problems, and periodontitis, canker sore and the like are easy to develop if the oral cavity problems are solved by the oral cavity problems; the canker sore is usually found on the lingual surface, lips, gums, etc. The oral ulcer is severe in pain during the onset, the local burning pain is obvious, the serious people can influence diet and speaking, bad breath, chronic pharyngitis and the like can also be complicated, and if the oral ulcer is not treated in time, great inconvenience is caused to daily life.
In the prior art, aiming at the treatment of oral diseases, a spray medicine is generally selected to spray a lesion part in an oral cavity or a patient takes oral pills, and as the patient can not accurately judge the accurate position of the lesion part in the oral cavity, the patient can not spray the medicine to a target position when holding the spray medicine, so that the treatment of the oral diseases is influenced; the pill medicines have the problems of slow dissolution, easy mistaking, and the like, and are difficult to meet the requirements of patients on rapid treatment of oral diseases.
The invention provides a nursing liquid explosion bead, a production process and intelligent production equipment, which are suitable for treating oral diseases, particularly oral ulcer diseases, and specifically described below with reference to the embodiment:
example 1
Based on this, please refer to fig. 1, the embodiment of the present application provides a nursing liquid explosion bead, the nursing liquid explosion bead includes an explosion bead content liquid and an explosion bead wall glue liquid, and the mass ratio of the explosion bead content liquid to the explosion bead wall glue liquid is 100:1, the bead explosion content liquid comprises: the blumea balsamifera extract comprises blumea balsamifera extract, a cosolvent, a bacteriostat and a solvent, wherein the cosolvent is polyoxyethylene hydrogenated castor oil, the solvent is 15% ethanol, and the mass fraction of the blumea balsamifera extract is 0.2% based on the mass of the explosive bead content liquid; the bead wall material glue solution comprises acacia, glycerol, lemon yellow and acetate starch, wherein the mass ratio of the acacia, the glycerol, the lemon yellow and the acetate starch is as follows: 100:80:5:20;
the acacia is light yellow block or white powder, has high solubility, the mixing ratio of the acacia to water can reach 60%, the acacia still has fluidity, no gel, no precipitation and good film forming property, the acacia is aqueous gum, the acacia cannot be dissolved in oil and alcohol, the acacia gum liquid is a hardened adhesive film after being volatilized, a film with high density is formed, and the acacia gum is suitable for main components of the explosion wall material glue.
In the embodiment of the invention, the mass fraction of the dissolution promoter is 0.1% based on the mass of the content liquid of the explosion beads, in the embodiment, polyoxyethylene hydrogenated castor oil (RH 40) is selected as the dissolution promoter, ethanol is selected as the solvent, and the mass of the dissolution promoter required for dissolving the blumea balsamifera extract with certain mass is smaller in the ethanol with the same volume fraction, namely, the polyoxyethylene hydrogenated castor oil can promote the dissolution of the blumea balsamifera extract in the ethanol;
the mass fraction of the antibacterial agent is 0.2%, the antibacterial agent is A.SAP, and the surface active ingredient contained in the A.SAP can generate barriers to microbial enzymes so as to inhibit the self occurrence mechanism of the antibacterial agent, thereby achieving the effects of sterilization and bacteriostasis, and meanwhile, the A.SAP has high safety, wide antibacterial range, obvious sterilization effect and long-lasting effect; the antibacterial agent can also be an ornidazole stock solution, and the ornidazole stock solution can better inhibit the growth of bacteria in the oral cavity of a patient with oral mucosa ulceration, promote the repair of the oral mucosa, improve the prognosis of diseases and prevent recurrence.
The invention also discloses a production process of the nursing liquid explosion bead, which comprises the following steps:
step one, preparing a bead explosion content liquid: adding solvent into blumea balsamifera extract and cosolvent, stirring until the extract and the cosolvent are dissolved uniformly, adding antibacterial agent, continuously stirring for 30 minutes, standing, and filtering to obtain a bursting bead content liquid;
Step two, preparing a bead explosion wall material glue solution: mixing acetate starch and half of glycerol, grinding by a grinder, filtering to obtain a mixture, adding the mixture, lemon yellow and the rest glycerol into a mixing reaction kettle, stirring, adding acacia to uniform glue solution while stirring, stopping stirring, standing, vacuumizing to a vacuum degree of-0.05 Mpa, and degassing for 1 hour until the glue solution has no bubbles, thus obtaining the blasting bead wall material glue solution;
thirdly, circulating the explosion bead wall material glue solution under the action of a magnetic stirrer, dripping the explosion bead content solution into the flowing explosion bead wall material glue solution by utilizing three-phase flow pill dropping equipment, dripping the explosion bead content solution into the explosion bead wall material glue solution to form a sphere, growing until the coating reaches the thickness requirement, removing forming liquid or floccules on the surface of the explosion bead by using slow flowing water, and collecting and fishing out the explosion bead in a wet state;
putting the explosion beads in a wet state into drying equipment for drying, and putting the dried explosion beads into a drying room in a temperature and humidity balance environment for standing until the water content reaches the requirement of the explosion beads of a finished product;
in the first step of the embodiment of the invention, the preparation method of the blumea balsamifera extract comprises the following steps: steam distilling blumea balsamifera to obtain volatile oil, filtrate and residue respectively, drying the filtrate to obtain a first extract, extracting the residue, concentrating and extracting to obtain a second extract, and mixing the volatile oil, the first extract and the second extract to obtain the blumea balsamifera extract;
Further, the method for extracting, concentrating and extracting the dregs comprises the following steps: the residue was first extracted with ethanol, the extract was filtered and the filtrate was concentrated to a thick paste having a density of 1.2 at 40 ℃, extracted with ethyl acetate of the same weight as the thick paste, ethyl acetate was recovered and dried to obtain a second extract.
In the embodiment of the invention, the method for detecting the finished product explosive beads is further included, and comprises the following steps:
a. measuring a bead explosion parameter of the bead explosion through detection equipment, wherein the bead explosion parameter comprises the mass and the volume of the bead explosion, the mass and the volume of a bead explosion content liquid and the mass and the volume of a bead explosion wall material glue liquid;
b. setting a threshold value of the bead explosion parameter, and comparing the threshold value with the measured bead explosion parameter to obtain a comparison result;
c. judging whether the produced explosive beads are qualified or not according to the comparison result, and when the produced explosive beads are unqualified, readjusting the process parameters until the produced explosive beads reach the requirements, so that the condition that the explosive beads are not broken and unmatched when being put on a production line is ensured.
Example 2
Referring to fig. 1, an embodiment of the present application provides a nursing liquid explosion bead, where the nursing liquid explosion bead includes an explosion bead content liquid and an explosion bead wall glue liquid, and a mass ratio of the explosion bead content liquid to the explosion bead wall glue liquid is 100:3, the bead explosion content liquid comprises: the blumea balsamifera extract comprises blumea balsamifera extract, a cosolvent, a bacteriostat and a solvent, wherein the cosolvent is polyoxyethylene hydrogenated castor oil, the solvent is 30% ethanol, and the mass fraction of the blumea balsamifera extract is 1% based on the mass of the explosive bead content liquid; the bead wall material glue solution comprises acacia, glycerol, lemon yellow and acetate starch, wherein the mass ratio of the acacia, the glycerol, the lemon yellow and the acetate starch is as follows: 100:80:5:20;
The acacia is light yellow block or white powder, has high solubility, the mixing ratio of the acacia to water can reach 60%, the acacia still has fluidity, no gel, no precipitation and good film forming property, the acacia is aqueous gum, the acacia cannot be dissolved in oil and alcohol, the acacia gum liquid is a hardened adhesive film after being volatilized, a film with high density is formed, and the acacia gum is suitable for main components of the explosion wall material glue.
In the embodiment of the invention, the mass fraction of the dissolution promoter is 0.5% based on the mass of the content liquid of the explosion beads, in the embodiment, polyoxyethylene hydrogenated castor oil (RH 40) is selected as the dissolution promoter, ethanol is selected as the solvent, and the mass of the dissolution promoter required for dissolving the blumea balsamifera extract with certain mass is smaller in the ethanol with the same volume fraction, namely, the polyoxyethylene hydrogenated castor oil can promote the dissolution of the blumea balsamifera extract in the ethanol;
the mass fraction of the antibacterial agent is 0.8%, the antibacterial agent is A.SAP, and the surface active ingredient contained in the A.SAP can generate barriers to microbial enzymes so as to inhibit the self occurrence mechanism of the antibacterial agent, thereby achieving the effects of sterilization and bacteriostasis; the antibacterial agent can also be an ornidazole stock solution, and the ornidazole stock solution can better inhibit the growth of bacteria in the oral cavity of a patient with oral mucosa ulceration, promote the repair of the oral mucosa, improve the prognosis of diseases and prevent recurrence.
The invention also discloses a production process of the nursing liquid explosion bead, which comprises the following steps:
step one, preparing a bead explosion content liquid: adding solvent into blumea balsamifera extract and cosolvent, stirring until the extract and the cosolvent are dissolved uniformly, adding antibacterial agent, continuously stirring for 45 minutes, standing, and filtering to obtain a bursting bead content liquid;
step two, preparing a bead explosion wall material glue solution: mixing acetate starch and half of glycerol, grinding by a grinder, filtering to obtain a mixture, adding the mixture, lemon yellow and the rest glycerol into a mixing reaction kettle, stirring, adding acacia to uniform glue solution while stirring, stopping stirring, standing, vacuumizing to a vacuum degree of-0.1 Mpa, and degassing for 1.5 hours until the glue solution has no bubbles, thus obtaining the explosion wall glue solution;
thirdly, circulating the explosion bead wall material glue solution under the action of a magnetic stirrer, dripping the explosion bead content solution into the flowing explosion bead wall material glue solution by utilizing three-phase flow pill dropping equipment, dripping the explosion bead content solution into the explosion bead wall material glue solution to form a sphere, growing until the coating reaches the thickness requirement, removing forming liquid or floccules on the surface of the explosion bead by using slow flowing water, and collecting and fishing out the explosion bead in a wet state;
Putting the explosion beads in a wet state into drying equipment for drying, and putting the dried explosion beads into a drying room in a temperature and humidity balance environment for standing until the water content reaches the requirement of the explosion beads of a finished product;
in the first step of the embodiment of the invention, the preparation method of the blumea balsamifera extract comprises the following steps: steam distilling blumea balsamifera to obtain volatile oil, filtrate and residue respectively, drying the filtrate to obtain a first extract, extracting the residue, concentrating and extracting to obtain a second extract, and mixing the volatile oil, the first extract and the second extract to obtain the blumea balsamifera extract;
further, the method for extracting, concentrating and extracting the dregs comprises the following steps: the residue was first extracted with ethanol, the extract was filtered and the filtrate was concentrated to a thick paste having a density of 1.2 at 60 ℃, extracted with ethyl acetate of the same weight as the thick paste, ethyl acetate was recovered and dried to obtain a second extract.
In the embodiment of the invention, the method for detecting the finished product explosive beads is further included, and comprises the following steps:
a. measuring a bead explosion parameter of the bead explosion through detection equipment, wherein the bead explosion parameter comprises the mass and the volume of the bead explosion, the mass and the volume of a bead explosion content liquid and the mass and the volume of a bead explosion wall material glue liquid;
b. Setting a threshold value of the bead explosion parameter, and comparing the threshold value with the measured bead explosion parameter to obtain a comparison result;
c. judging whether the produced explosive beads are qualified or not according to the comparison result, and when the produced explosive beads are unqualified, readjusting the process parameters until the produced explosive beads reach the requirements, so that the condition that the explosive beads are not broken and unmatched when being put on a production line is ensured.
Example 3
Referring to fig. 1, an embodiment of the present application provides a nursing liquid explosion bead, where the nursing liquid explosion bead includes an explosion bead content liquid and an explosion bead wall glue liquid, and a mass ratio of the explosion bead content liquid to the explosion bead wall glue liquid is 100:2, the bead explosion content liquid comprises: the blumea balsamifera extract comprises blumea balsamifera extract, a cosolvent, a bacteriostat and a solvent, wherein the cosolvent is polyoxyethylene hydrogenated castor oil, the solvent is 25% ethanol, and the mass fraction of the blumea balsamifera extract is 0.5% based on the mass of the explosive bead content liquid; the bead wall material glue solution comprises acacia, glycerol, lemon yellow and acetate starch, wherein the mass ratio of the acacia, the glycerol, the lemon yellow and the acetate starch is as follows: 100:80:5:20;
the acacia is light yellow block or white powder, has high solubility, the mixing ratio of the acacia to water can reach 60%, the acacia still has fluidity, no gel, no precipitation and good film forming property, the acacia is aqueous gum, the acacia cannot be dissolved in oil and alcohol, the acacia gum liquid is a hardened adhesive film after being volatilized, a film with high density is formed, and the acacia gum is suitable for main components of the explosion wall material glue.
In the embodiment of the invention, the mass fraction of the dissolution promoter is 0.3% based on the mass of the content liquid of the explosion beads, in the embodiment, polyoxyethylene hydrogenated castor oil (RH 40) is selected as the dissolution promoter, ethanol is selected as the solvent, and the mass of the dissolution promoter required for dissolving the blumea balsamifera extract with certain mass is smaller in the ethanol with the same volume fraction, namely, the polyoxyethylene hydrogenated castor oil can promote the dissolution of the blumea balsamifera extract in the ethanol;
the mass fraction of the antibacterial agent is 0.5%, the antibacterial agent is A.SAP, and the surface active ingredient contained in the A.SAP can generate barriers to microbial enzymes so as to inhibit the self occurrence mechanism of the antibacterial agent, thereby achieving the effects of sterilization and bacteriostasis, and meanwhile, the A.SAP has high safety, wide antibacterial range, obvious sterilization effect and long-lasting effect; the antibacterial agent can also be an ornidazole stock solution, and the ornidazole stock solution can better inhibit the growth of bacteria in the oral cavity of a patient with oral mucosa ulceration, promote the repair of the oral mucosa, improve the prognosis of diseases and prevent recurrence.
The invention also discloses a production process of the nursing liquid explosion bead, which comprises the following steps:
step one, preparing a bead explosion content liquid: adding solvent into blumea balsamifera extract and cosolvent, stirring until the extract and the cosolvent are dissolved uniformly, adding antibacterial agent, continuously stirring for 40 minutes, standing, and filtering to obtain a bursting bead content liquid;
Step two, preparing a bead explosion wall material glue solution: mixing acetate starch and half of glycerol, grinding by a grinder, filtering to obtain a mixture, adding the mixture, lemon yellow and the rest glycerol into a mixing reaction kettle, stirring, adding acacia to uniform glue solution while stirring, stopping stirring, standing, vacuumizing to a vacuum degree of-0.08 Mpa, and degassing for 1.2 hours until the glue solution has no bubbles, thus obtaining the explosion wall glue solution;
thirdly, circulating the explosion bead wall material glue solution under the action of a magnetic stirrer, dripping the explosion bead content solution into the flowing explosion bead wall material glue solution by utilizing three-phase flow pill dropping equipment, dripping the explosion bead content solution into the explosion bead wall material glue solution to form a sphere, growing until the coating reaches the thickness requirement, removing forming liquid or floccules on the surface of the explosion bead by using slow flowing water, and collecting and fishing out the explosion bead in a wet state;
putting the explosion beads in a wet state into drying equipment for drying, and putting the dried explosion beads into a drying room in a temperature and humidity balance environment for standing until the water content reaches the requirement of the explosion beads of a finished product;
in the first step of the embodiment of the invention, the preparation method of the blumea balsamifera extract comprises the following steps: steam distilling blumea balsamifera to obtain volatile oil, filtrate and residue respectively, drying the filtrate to obtain a first extract, extracting the residue, concentrating and extracting to obtain a second extract, and mixing the volatile oil, the first extract and the second extract to obtain the blumea balsamifera extract;
Further, the method for extracting, concentrating and extracting the dregs comprises the following steps: the residue was first extracted with ethanol, the extract was filtered and the filtrate was concentrated to a thick paste having a density of 1.2 at 50 ℃, extracted with ethyl acetate of the same weight as the thick paste, ethyl acetate was recovered and dried to obtain a second extract.
In the embodiment of the invention, the method for detecting the finished product explosive beads is further included, and comprises the following steps:
a. measuring a bead explosion parameter of the bead explosion through detection equipment, wherein the bead explosion parameter comprises the mass and the volume of the bead explosion, the mass and the volume of a bead explosion content liquid and the mass and the volume of a bead explosion wall material glue liquid;
b. setting a threshold value of the bead explosion parameter, and comparing the threshold value with the measured bead explosion parameter to obtain a comparison result;
c. judging whether the produced explosive beads are qualified or not according to the comparison result, and when the produced explosive beads are unqualified, readjusting the process parameters until the produced explosive beads reach the requirements, so that the condition that the explosive beads are not broken and unmatched when being put on a production line is ensured.
Example 4
Referring to fig. 2-3, the invention also discloses an intelligent production device for the explosion beads of the care solution, which comprises three-phase flow pill dropping equipment, detection equipment for detecting the quality of the explosion beads formed by dripping and drying equipment for removing water from the explosion beads after forming, wherein the drying equipment comprises a first cylinder 100, a second cylinder 200 and a drying pipe 400, the second cylinder 200 is rotatably arranged in the first cylinder 100, and two ends of the second cylinder 200 extend out of the first cylinder 100 and form a feeding section and a discharging section so as to enable the formed explosion beads to enter the second cylinder 200 from a feeding pipe and be discharged from the discharging section after being cleaned; the drying pipe 400 is communicated with the blanking section, the drying pipe 400 receives the wet formed explosion beads discharged from the blanking section, and the wet formed explosion beads are dried;
In the embodiment of the present invention, the upper and lower sides of the inner wall of the first cylinder 100 are respectively provided with a water inlet cavity 140 and a water outlet cavity 150, the water inlet cavity 140 and the water outlet cavity 150 are both communicated with a cavity formed inside the first cylinder 100, at least one liquid inlet 110 is disposed on the upper side of the first cylinder 100, the liquid inlet 110 is communicated with the water inlet cavity 140, at least one liquid outlet 120 is disposed on the lower side of the first cylinder 100, the liquid outlet 120 is communicated with the water outlet cavity 150, a liquid detergent (water or cleaning solution) for cleaning the molded explosion beads is introduced into the water inlet cavity 140 from the liquid inlet 100, sprayed to the second cylinder 200 via the water inlet cavity 140, the molded explosion beads inside the second cylinder 200 are cleaned, the cleaned wastewater is collected and enters the water outlet cavity 150, and then discharged from the liquid outlet 120;
further, the water inlet chamber 140 and the water outlet chamber 150 are both in an annular structure, and the water inlet chamber 140 and the water outlet chamber 150 of the annular structure have strong water storage capacity and water outlet and water inlet capacity, so that the liquid detergent can be quickly sprayed to the second cylinder 200 and the waste water generated by cleaning can be quickly recovered;
in addition, it is further described that, during the process of cleaning the molded bead, the first cylinder 100 is kept fixed, the water inlet chamber 140 is located above the chamber formed inside the first cylinder 100, and the water outlet chamber 150 is located below the chamber formed inside the first cylinder 100, so that the liquid cleaning agent flows to the second cylinder 200 from top to bottom, and flows into the water outlet chamber 150 after the cleaning is completed.
In order to ensure that the liquid cleaning agent can flow into and out of the second cylinder 200 and can fully contact with the molded blasting beads, a plurality of through holes 250 are circumferentially formed in the cylinder wall of the second cylinder 200 positioned in the first cylinder 100, so that the liquid cleaning agent passes through the through holes 250 and enters the interior of the second cylinder 200 to clean the molded blasting beads in the second cylinder 200, and in addition, the second cylinder 200 drives the molded blasting beads in the interior to rotate in the rotating process due to the rotating arrangement of the second cylinder 200, so that the molded blasting beads fully contact with the liquid cleaning agent and the cleaning of the molded blasting beads is ensured;
also, the diameter of the through hole 250 is smaller than the diameter of the molded bead so as not to extrude the molded bead from the through hole 250.
In the embodiment of the present invention, a push plate 230 for pushing the molded blasting beads to move and a push rod 220 for driving the push plate 230 to slide in the second cylinder 200 are provided in the second cylinder 200, after the molded blasting beads enter the feeding section of the second cylinder 200, the push plate 230 is driven to move by the push rod 220, the molded blasting beads in the second cylinder 200 are pushed to move by the push plate 230, so that the molded blasting beads move to the blanking section, and in the moving process, the molded blasting beads are cleaned by a liquid cleaning agent, and it can be understood that the present invention further comprises a telescopic mechanism for controlling the push rod 220 to move, and the telescopic mechanism can be a linear movement control device such as a cylinder, a hydraulic rod, etc.;
In addition, a feeding port 210 is formed in the feeding section of the second cylinder 200, a discharging port 240 is formed in the discharging section of the second cylinder 200, and the discharging port 240 is communicated with the drying pipe 400;
further, the drying tube 400 includes an annular side wall and a drying channel surrounded by the annular side wall, the annular side wall includes an inner wall, an outer wall and a heating cavity formed between the inner wall and the outer wall, a plurality of air holes are formed in the inner wall, at least one hot air pipe is connected to the outer wall and communicated with the heating cavity, hot air is introduced into the heating cavity through the hot air pipe, the hot air is discharged into the drying channel through the air holes, wet formed explosive beads discharged from the discharging opening 240 roll in the drying channel, the hot air dries the rolled formed explosive beads, and the moisture of the formed explosive beads is rapidly reduced.
In the embodiment of the present invention, the driving mechanism 300 is further included to control the rotation of the second cylinder 200, where the driving mechanism 300 includes a rotating shaft 310, a gear 320 fixedly installed on the rotating shaft 310, and a gear ring 330 fixedly installed on the second cylinder 200, the gear 320 is meshed with the gear ring 330, and drives the rotating shaft 310 to rotate, and drives the gear ring 330 and the second cylinder 200 to rotate through the gear 320;
It should be noted that the device further comprises a frame fixedly arranged and a motor for driving the rotating shaft 310 to rotate, the rotating shaft 310 is rotatably installed on the frame, the output end of the motor is fixedly connected with the rotating shaft, and the frame and the motor can be fixedly connected with the first cylinder 100 due to the fixed arrangement of the first cylinder 100.
Referring to fig. 5, the detection apparatus includes an image acquisition module 500, an image processing module 600, and a data analysis module 700, wherein:
the image acquisition module 500 is used for acquiring an original image formed by the bead blasting drip;
the image processing module 600 is configured to fit the original image to form a processed image, where the processed image includes a bead wall material glue solution image and a bead content liquid image; is also used for obtaining the diameter D of the explosive bead content liquid based on the explosive bead wall material glue liquid image and the explosive bead content liquid image 1 Diameter D of explosion bead wall glue solution 2 ；
The data analysis module 700 is configured to obtain known data and detection data, where the known data includes a density of the bead blasting content liquid and a density of the bead blasting wall material glue liquid, and the detection data includes a diameter D of the bead blasting content liquid 1 Diameter D of explosion bead wall glue solution 2 The method comprises the steps of carrying out a first treatment on the surface of the The method is also used for calculating the explosion bead parameters according to the known data and the detection data, wherein the explosion bead parameters comprise the mass and the volume of the explosion bead, the mass and the volume of the explosion bead content liquid and the mass and the volume of the explosion bead wall material glue liquid;
In the embodiment of the invention, the mass of the content liquid of the explosion beads
Figure BDA0003645019540000121
Volume of content liquid of explosive beads
Figure BDA0003645019540000122
The mass of the glue solution of the explosion wall material>
Figure BDA0003645019540000123
The volume of the glue solution of the explosion wall material>
Figure BDA0003645019540000124
Explosive bead volume->
Figure BDA0003645019540000125
Mass m of explosion bead 3 ＝m 1 +m 2 Wherein:
D 1 diameter of content liquid of explosive beads D 2 Is the diameter ρ of the glue solution of the explosion bead wall material 1 For the density of the content liquid of the explosion beads,ρ 2 is the glue density of the explosion wall material.
In the embodiment of the present invention, the method for fitting the original image to form the processed image by the image processing module 600 is as follows: extracting a detection area through image gray scale based on an edge segmentation method, determining an edge by utilizing a Canny algorithm, fitting the detected edge into a circle by adopting a least square method, and obtaining an inner circle diameter and an outer circle diameter, wherein the inner circle diameter is the diameter of the explosive bead content liquid, and the outer circle diameter is the diameter of the explosive bead wall glue liquid;
it should be further noted that, by measuring each bead explosion parameter of N beads in a given time T by the detection device, calculating the average value of each bead explosion parameter by calculating the average value, setting the average value threshold of each bead explosion parameter, comparing the calculated average value with the set threshold, and determining whether the bead explosion produced in the time T is qualified or not, if not, the process parameter needs to be readjusted until the produced bead explosion reaches the requirement.
Comparative experiments
1. Experiment for healing dental ulcer
1. 50 patients with canker sore aged 9-71 years old (41.6+ -3.0) on average were selected as subjects;
2. grouping: the 50 study subjects were equally divided into 5 groups, experimental examples 1-3, comparative examples 1-2, wherein:
experimental example 1 group for treating canker sore using the pop beads produced in example 1, experimental example 2 group for treating canker sore using the pop beads produced in example 2, experimental example 3 group for treating canker sore using the pop beads produced in example 3, comparative example 1 group for treating canker sore using a Jinhoujian spray (Guizhou Hongyu pharmaceutical Co., ltd., lot number 161038), comparative example 2 group not administered, and natural healing canker sore
3. The experimental method comprises the following steps: the compound borax solution is given to patients before the use of the medicine for gargling, the surface is sucked by a sterilizing cotton swab, the medicines are used for each time before the patient is at early, middle, late and sleeping, the quality of the medicines used by each patient is equal, after all the patients are used, the patients are observed for 30 minutes to see whether any possible sign of acute allergic reaction exists, after the oral ulcer of the patients heals, the time (day) required for healing is recorded, and finally the average time for each group of patients to heal the oral ulcer is calculated, and the results are shown in table 1:
TABLE 1
Experimental example 1 Experimental example 2 Experimental example 3 Comparative example 1 Comparative example 2
Healing time (Tian) 5 4 5 7 9
2. Antibacterial effect test experiment
1. Experimental strain: streptococcus mutans (ATCC 25923), candida albicans (ATCC 76615), staphylococcus aureus (containing beta-lactamase);
2. the experimental method comprises the following steps:
(1) The explosive beads produced in examples 1 to 3 were selected as experimental examples 1 to 3, and sterile water was selected as a comparative example;
(2) Crushing the explosive beads in the experimental examples 1-3, and diluting the explosive beads with medical physiological saline to prepare three concentrations of 1:10, 1:100 and 1:1000;
(3) Sterilizing a filter paper sheet with the diameter of 6mm, and then pasting 4-6 filter paper sheets on the surface of a prepared bacteria-containing culture medium; taking 10 mu l of the extracting solution with each diluted concentration in the examples 1-3, sequentially adding the extracting solution to each filter paper sheet, putting the agar plate inoculated with candida albicans and staphylococcus aureus into a common incubator at 37 ℃, and incubating for 24 hours; placing the agar culture medium inoculated with the streptococcus mutans into an anaerobic bag for incubation for 48 hours at 37 ℃, and accurately measuring the diameter (mm) of a bacteria inhibition ring;
(4) Repeating the step (3) for 10 times, recording the diameter (mm) of the bacteriostasis ring measured each time, and taking an average value, wherein the results are shown in tables 2-4;
table 2 diameter of the inhibition ring for each group at 1:10 dilution
Experimental example 1 Experimental example 2 Experimental example 3 Comparative example
Streptococcus mutans 36.3 37.5 38.4 16.2
Candida albicans 38.4 36.6 37.2 15.1
Staphylococcus aureus 35.6 39.5 35.6 14.2
Table 3 diameter of the inhibition ring for each group at 1:100 dilution
Experimental example 1 Experimental example 2 Experimental example 3 Comparative example
Streptococcus mutans 29.3 28.2 26.9 12.2
Candida albicans 27.5 30.1 28.3 10.3
Staphylococcus aureus 28.6 27.8 28.8 12.1
Table 4 diameter of the inhibition ring for each group at 1:1000 dilution
Experimental example 1 Experimental example 2 Experimental example 3 Comparative example
Streptococcus mutans 12.3 11.8 12.1 2.3
Candida albicans 13.2 10.9 10.9 2.8
Staphylococcus aureus 10.6 11.9 11.5 3.2
3. Experimental results
As can be seen from Table 1, the nursing liquid explosion beads produced in examples 1-3 of the present application have obvious treatment effect on patients with oral ulcer, and the treatment time is short and the healing time is fast;
as can be seen from Table 2, the nursing liquid explosion beads produced in examples 1-3 of the application have good antibacterial and bactericidal effects, and have remarkable bactericidal effects on common streptococcus mutans, candida albicans and staphylococcus aureus.
In conclusion, the blumea balsamifera extract, the cosolvent, the antibacterial agent and the solvent are used as main components of the bead blasting content liquid, and the acacia gum is used as main components of the bead blasting wall material glue liquid, so that the blumea balsamifera extract can inhibit bacterial growth in the oral cavity of a user, has obvious treatment effects on gingivitis, periodontitis and gingival bleeding, especially on patients with canker sores, can maintain normal oral microbial flora, and ensures oral health.
The foregoing description of the preferred embodiments of the invention is not intended to be limiting, but rather is intended to cover all modifications, equivalents, and alternatives falling within the spirit and principles of the invention.

Claims (7)

1. The nursing liquid explosion bead is characterized by comprising an explosion bead content liquid and an explosion bead wall material glue liquid, wherein the mass ratio of the explosion bead content liquid to the explosion bead wall material glue liquid is 100: (1-3), wherein:
the explosive bead content liquid comprises: the blumea balsamifera extract, a cosolvent, a bacteriostatic agent and a solvent, wherein the cosolvent is polyoxyethylene hydrogenated castor oil, the bacteriostatic agent is A.SAP or ornidazole stock solution, the solvent is 15-30% ethanol, the mass fraction of the blumea balsamifera extract is 0.2-1% based on the mass of the explosive bead content solution, and the mass fraction of the bacteriostatic agent is 0.2-0.8%;
the bead wall material glue solution comprises acacia, glycerol, lemon yellow and acetate starch, wherein the mass ratio of the acacia, the glycerol, the lemon yellow and the acetate starch is as follows: 100:80:5:20.
2. The care solution explosion bead as set forth in claim 1, wherein: the mass fraction of the solvent is 0.1-0.5% based on the mass of the content liquid of the explosion beads.
3. A process for producing the care solution explosion beads according to any one of claims 1 to 2, which is characterized in that: the method comprises the following steps:
step one, preparing a bead explosion content liquid: adding solvent into blumea balsamifera extract and cosolvent, stirring until the extract and the cosolvent are dissolved uniformly, adding antibacterial agent, continuously stirring for 30-45 min, standing, and filtering to obtain a bursting bead content liquid;
step two, preparing a bead explosion wall material glue solution: mixing acetate starch and half of glycerol, grinding by a grinder, filtering to obtain a mixture, adding the mixture, lemon yellow and the rest glycerol into a mixing reaction kettle, stirring, adding acacia to uniform glue solution while stirring, stopping stirring, standing, vacuumizing to a vacuum degree of-0.05 to-0.1 Mpa, and degassing for 1-1.5 hours until the glue solution has no bubbles, thus obtaining the explosion bead wall glue solution;
thirdly, circulating the explosion bead wall material glue solution under the action of a magnetic stirrer, dripping the explosion bead content solution into the flowing explosion bead wall material glue solution by utilizing three-phase flow pill dropping equipment, dripping the explosion bead content solution into the explosion bead wall material glue solution to form a sphere, growing until the coating reaches the thickness requirement, removing forming liquid or floccules on the surface of the explosion bead by using slow flowing water, and collecting and fishing out the explosion bead in a wet state;
And fourthly, putting the explosion beads in a wet state into drying equipment for drying, and putting the dried explosion beads into a drying room in a temperature and humidity balance environment for standing until the water content reaches the requirement of the explosion beads of the finished product.
4. A process for producing a care solution explosion bead as defined in claim 3, wherein: in the first step, the preparation method of the blumea balsamifera extract comprises the following steps: and (3) carrying out steam distillation on blumea balsamifera to obtain volatile oil, filtrate and medicinal residues respectively, drying the filtrate to obtain a first extract, extracting, concentrating and extracting the medicinal residues to obtain a second extract, and mixing the volatile oil, the first extract and the second extract to obtain the blumea balsamifera extract.
5. A process for producing a care solution explosion bead as defined in claim 3, wherein: the method for detecting the finished product explosive beads is also included, and comprises the following steps:
a. measuring a bead explosion parameter of the bead explosion through detection equipment, wherein the bead explosion parameter comprises the mass and the volume of the bead explosion, the mass and the volume of a bead explosion content liquid and the mass and the volume of a bead explosion wall material glue liquid;
b. setting a threshold value of the bead explosion parameter, and comparing the threshold value with the measured bead explosion parameter to obtain a comparison result;
c. Judging whether the produced explosive beads are qualified or not according to the comparison result, and when the produced explosive beads are unqualified, readjusting the process parameters until the produced explosive beads reach the requirements, so that the condition that the explosive beads are not broken and unmatched when being put on a production line is ensured.
6. An intelligent production device for blasting beads of a care solution according to any one of claims 1-2, comprising three-phase flow pill dropping equipment, detection equipment for detecting quality of the blasted beads formed by dripping, and drying equipment for removing moisture from the blasted beads after forming, and the intelligent production device is characterized in that: the drying apparatus includes:
the inner wall of the first cylinder is provided with a water inlet cavity for liquid cleaning agent to enter and a water outlet cavity for liquid cleaning agent to be discharged, and the water inlet cavity and the water outlet cavity are communicated with a cavity formed in the first cylinder;
the second cylinder body is rotatably arranged in the first cylinder body, and two ends of the second cylinder body extend out of the first cylinder body and extend to form a feeding section for the explosive beads to enter and a discharging section for the explosive beads to discharge; the second cylinder is positioned in the first cylinder, and a plurality of through holes for liquid cleaning agent to enter the second cylinder are circumferentially formed in the cylinder wall of the second cylinder, so that the liquid cleaning agent enters the second cylinder to clean the formed explosion beads in the second cylinder; the second cylinder is internally provided with a push plate for pushing the formed explosive beads to move and a push rod for driving the push plate to slide in the second cylinder, and the push rod is controlled to drive the push plate to move so that the push plate pushes the formed explosive beads in the second cylinder to move from a feeding section to a discharging section;
The drying pipe is communicated with the blanking section and comprises an annular side wall and a drying channel surrounded by the annular side wall, the annular side wall comprises an inner wall, an outer wall and a heating cavity formed between the inner wall and the outer wall, a plurality of air holes are formed in the inner wall, hot air introduced into the heating cavity passes through the air holes to enter the drying channel, and wet forming explosion beads moving in the drying channel are dried.
7. The intelligent production device for the explosion beads of the nursing liquid according to claim 6, wherein: the detection apparatus includes:
the image acquisition module is used for acquiring an original image formed by the bead blasting drip;
the image processing module is used for fitting the original image to form a processing image, wherein the processing image comprises a bead blasting wall material glue solution image and a bead blasting content liquid image; is also used for obtaining the diameter D of the explosive bead content liquid based on the explosive bead wall material glue liquid image and the explosive bead content liquid image 1 Diameter D of explosion bead wall glue solution 2 ；
The data analysis module is used for acquiring known data and detection data, wherein the known data comprise the density of the explosive bead content liquid and the density of the explosive bead wall glue liquid which are input by a user, and the detection data comprise the diameter of the explosive bead content liquid and the diameter of the explosive bead wall glue liquid; and is also used for calculating the bead blasting parameters according to the known data and the detection data.
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