CN114903050B - Insecticidal composition containing permethrin and beta-cypermethrin and application thereof - Google Patents
Insecticidal composition containing permethrin and beta-cypermethrin and application thereof Download PDFInfo
- Publication number
- CN114903050B CN114903050B CN202110177309.8A CN202110177309A CN114903050B CN 114903050 B CN114903050 B CN 114903050B CN 202110177309 A CN202110177309 A CN 202110177309A CN 114903050 B CN114903050 B CN 114903050B
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- Prior art keywords
- permethrin
- cypermethrin
- agent
- percent
- beta
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Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N53/00—Biocides, pest repellants or attractants, or plant growth regulators containing cyclopropane carboxylic acids or derivatives thereof
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/30—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests characterised by the surfactants
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Abstract
The invention discloses an insecticidal composition containing permethrin and beta-cypermethrin and application thereof, wherein the active ingredients consist of permethrin and beta-cypermethrin, and the weight ratio of the permethrin to the beta-cypermethrin is 1: 20-20: 1. according to the invention, the permethrin and the high-efficiency cypermethrin are compounded and processed into wettable powder, water dispersible granule or suspending agent, so that the use of an organic solvent is reduced, the method is more environment-friendly, the method has an excellent lethal effect on public health pests, and meanwhile, the problems of storage agglomeration of the low-melting-point permethrin and the high-efficiency cypermethrin into wettable powder or water dispersible granule, storage crystallization and paste formation of the suspending agent are effectively solved by adding the high-molecular emulsifying dispersant. The compound pesticide is applied in a detention spraying mode, has remarkable synergistic effect on preventing and controlling public health pests, can reduce the application amount of the pesticide, saves cost, delays the generation of pesticide resistance of the pests, and is widely applied to hotels, schools, factories, families, farmers, farms, public places and the like.
Description
Technical Field
The invention relates to a sanitary insecticide, in particular to an insecticidal composition containing permethrin and beta-cypermethrin.
Background
The permethrin, also called permethrin, is a novel pyrethroid insecticide with high efficiency and low toxicity, has better effects on mosquitoes, flies and cockroaches, has the characteristics of high vapor pressure, good volatility and strong killing power, has high pest knockdown speed, and has more remarkable knockdown effect particularly in spraying and fumigation.
The high-efficiency cypermethrin is a pyrethroid insecticide, has higher biological activity, is a high-efficiency isomer of cypermethrin, and has the effects of contact killing and stomach poisoning. Broad insecticidal spectrum, high knockdown speed and high insecticidal activity. Is suitable for preventing and controlling pests on cotton, vegetables, fruit trees, tea trees, forests and other plants, and preventing and controlling various pests such as mosquitoes, flies, cockroaches, fleas, lice, bed bugs and the like in public health and animal husbandry.
In the existing spray products in the external environment field, a large number of single products are used for a long time to cause the pests such as mosquitoes, flies, cockroaches and the like to generate larger drug resistance, and the phenomenon of generally reducing the prevention effect also occurs in recent years. Therefore, an environment-friendly and efficient pesticide compound variety is needed at present to delay the generation of drug resistance of sanitary pests.
The permethrin and the high-efficiency permethrin both belong to low-melting-point raw medicines, the melting point of the permethrin is about 65-70 ℃, the melting point of the high-efficiency permethrin is about 60-65 ℃, the preparation of the permethrin into wettable powder or water dispersible granule is extremely easy to generate storage caking, the preparation of the suspending agent also can generate the problems of crystallization and creaming caused by the growth of storage crystals, and the like, so that the problem that how to prepare the low-melting-point raw medicines into the wettable powder, the water dispersible granule or the suspending agent is also a great difficulty in the preparation of the dosage form is solved.
Disclosure of Invention
Aiming at the defects in the prior art, the invention provides the insecticidal composition containing the permethrin and the beta-cypermethrin and the application thereof, and the invention combines the permethrin with the beta-cypermethrin, thereby not only improving the control effect on sanitary pests, delaying the generation of drug resistance of the sanitary pests, but also reducing the harm of organic solvents to the environment and being more friendly to the environment; the sanitary insecticidal composition has good insecticidal effect, is compounded with synergism, and is not easy to generate drug resistance.
In order to achieve the above purpose, the present invention adopts the following technical scheme:
The invention firstly provides an insecticidal composition containing permethrin and beta-cypermethrin, which is prepared by compounding permethrin and beta-cypermethrin, wherein the weight ratio of permethrin to beta-cypermethrin is 1: 20-20: 1.
In the technical scheme, the weight ratio of the permethrin to the beta-cypermethrin is 1: 10-10: 1.
The invention also provides an insecticide containing the permethrin and the beta-cypermethrin, which is wettable powder prepared from the insecticidal composition containing the permethrin and the beta-cypermethrin, a dispersing agent, a wetting agent, a stabilizing agent and a filler serving as raw materials, wherein the wettable powder comprises the following components in percentage by weight: 5 to 30 percent of insecticidal composition containing permethrin and beta-cypermethrin, 1 to 10 percent of dispersing agent, 1 to 5 percent of wetting agent, 5 to 10 percent of stabilizer and filler which are complemented to 100 percent.
In the technical scheme, the preparation method of the wettable powder comprises the following steps: according to the proportion, the insecticidal composition containing the permethrin and the beta-cypermethrin, the wetting agent, the dispersing agent, the stabilizing agent and the filler are added into a cooking machine to be uniformly mixed, and then the mixture is crushed in an air flow crusher to obtain the insecticidal composition.
The invention also provides an insecticide containing the permethrin and the beta-cypermethrin, which is a water dispersible granule prepared from the insecticidal composition containing the permethrin and the beta-cypermethrin, a dispersing agent, a wetting agent, a disintegrating agent, a binder, a stabilizing agent and a filler serving as raw materials, wherein the water dispersible granule comprises the following components in percentage by weight: 10 to 50 percent of compound insecticidal composition containing permethrin and beta-cypermethrin, 1 to 10 percent of dispersing agent, 1 to 5 percent of wetting agent, 1 to 10 percent of disintegrating agent, 0.1 to 1 percent of binding agent, 5 to 10 percent of stabilizing agent and filling agent which are complemented to 100 percent.
In the technical scheme, the water dispersible granule is prepared by the following steps: according to the proportion, the insecticidal composition containing the permethrin and the beta-cypermethrin, a wetting agent, a dispersing agent, a disintegrating agent, a binding agent, a stabilizing agent and a filler are added into a cooking machine to be uniformly mixed, then the mixture is crushed by an airflow crusher, the powder is put into a beaker, a proper amount of water is added into the beaker, the mixture is stirred and kneaded, and the mixture is extruded and granulated by a granulator and then dried to obtain the beta-cypermethrin insecticidal composition.
The invention also provides an insecticide containing the permethrin and the beta-cypermethrin, which is a suspending agent prepared by taking the insecticidal composition containing the permethrin and the beta-cypermethrin, a dispersing agent, a wetting agent, a thickening agent, a preservative, an antifreezing agent, an antifoaming agent, a stabilizing agent and deionized water as raw materials, wherein the suspending agent comprises the following components in percentage by weight: 5 to 30 percent of compound insecticidal composition containing permethrin and beta-cypermethrin, 1 to 10 percent of dispersing agent, 1 to 5 percent of wetting agent, 0.1 to 1 percent of thickening agent, 0.1 to 1 percent of preservative, 3 to 10 percent of antifreezing agent, 0.1 to 0.5 percent of defoaming agent, 5 to 10 percent of stabilizing agent and deionized water which are complemented to 100 percent.
In the technical scheme, the suspending agent is prepared by the following steps: according to the proportion, adding the insecticidal composition containing the permethrin and the beta-cypermethrin, a wetting agent, a dispersing agent, an antifreezing agent, a preservative, a defoaming agent, a stabilizing agent and deionized water into a beaker, uniformly mixing, transferring to a sand mill, adding zirconia beads into the sand mill, grinding for 2-3h, adding a thickening agent, continuously grinding for 0.5h, controlling the grain diameter D 95 to be below 5 microns, and filtering to remove the zirconia beads.
In the technical scheme, the dispersing agent is selected from any one of polycarboxylate, lignosulfonate, alkylphenol ethoxylate formaldehyde condensate, sulfate, alkylbenzene sulfonate calcium salt, naphthalene sulfonate formaldehyde condensate sodium salt, alkylphenol ethoxylate, fatty amine polyoxyethylene ether, fatty acid polyoxyethylene ester and glycerin fatty acid ester polyoxyethylene ether, or a mixture of two or more of the above components in any proportion.
In the above technical scheme, the wetting agent is selected from any one of alkylphenol polyoxyethylene ether formaldehyde condensate sulfate, alkylbenzene polyoxyethylene ether phosphate, phenethyl phenol polyoxyethylene ether phosphate, alkyl sulfate, alkyl sulfonate, naphthalene sulfonate, sodium dodecyl sulfate, nekal BX and dodecylbenzene sulfonic acid, or a mixture of two or more of them in any proportion.
In the technical scheme, the filler is selected from any one of kaolin, white carbon black, corn starch, attapulgite, light calcium carbonate, diatomite and bentonite, or a mixture of two or more of the above materials in any proportion.
In the above technical scheme, the disintegrating agent is selected from any one of sodium chloride, ammonium sulfate, sodium carbonate, sodium bicarbonate and sodium sulfate.
In the above technical scheme, the binder is selected from any one of methylcellulose, polyvinylpyrrolidone, polyvinyl alcohol, polyethylene glycol and sodium carboxymethylcellulose.
In the above technical scheme, the thickener is selected from any one of xanthan gum, sodium alginate, magnesium aluminum silicate, acacia and guar gum, or a mixture of two or more of the above materials mixed in any proportion.
In the above technical scheme, the preservative is selected from any one of potassium sorbate, sodium benzoate, pinocembrane and benzisothiazolinone.
In the above technical scheme, the antifreezing agent is selected from any one of ethylene glycol, propylene glycol, glycerol and urea.
In the above technical scheme, the defoamer is selected from any one of distearyl ethylenediamine, tributyl phosphate, silicone oil, cetyl alcohol and glycerol ricinoleate.
In the technical scheme, the stabilizer is selected from any one or a mixture of any two of secondary alkyl ammonium sulfate, alkyl sulfonyl chloride, urea-formaldehyde resin, polyalkylene glycol, polyacrylic acid, ethylene oxide-propylene oxide block polyether, vinyl acetate, ethyl acrylate and SP-SC3275 (belonging to cationic polycarboxylate copolymer, manufactured by Jiangsu qingyu chemical industry Co., ltd.) in any proportion. The stabilizer is a macromolecule emulsifying dispersant, and the problems that the low-melting-point permethrin and the high-efficiency permethrin are prepared into wettable powder or water dispersible granule storage caking, the suspending agent is prepared into suspension storage crystallization paste and the like can be effectively solved by adding the macromolecule emulsifying dispersant stabilizer.
The invention also provides application of the pesticide containing the permethrin and the beta-cypermethrin in preventing and controlling public health pests.
In the technical scheme, the public health pests refer to mosquitoes, flies, cockroaches and fleas; the application places comprise hotels, schools, factories, families, farmers, farms, public places and the like.
In the technical scheme, when the pesticide containing the permethrin and the beta-cypermethrin is used for controlling public health pests, the pesticide is applied in a detention spraying mode, the wettable powder is diluted 100-200 times by water, the water dispersible granule is diluted 100-200 times by water, the suspending agent is diluted 100-200 times by water and then sprayed on the surfaces of walls, doors and windows, ceilings, houses and the like, so that the compound pesticide remains on the surfaces of the objects, and the health pests die after contacting.
The technical scheme of the invention has the advantages that: according to the pesticide disclosed by the invention, the permethrin and the beta-cypermethrin are compounded to be processed into wettable powder, water dispersible granules or suspending agents, so that the use of an organic solvent is reduced, the pesticide is more environment-friendly, the pesticide has an obvious synergistic effect in preventing and controlling public health pests, the application amount of the pesticide can be reduced, the cost is saved, and the generation of drug resistance of pests is delayed. The pesticide is added with a high molecular emulsifying dispersant, so that the problems that the low-melting-point permethrin and the high-efficiency permethrin are prepared into wettable powder or water dispersible granule storage caking, the suspending agent is prepared into storage crystallization paste and the like are effectively solved.
Detailed Description
The following detailed description of the technical scheme of the present invention is provided, but the present invention is not limited to the following description, and the percentages in the following examples refer to weight percentages unless otherwise specified:
The invention is illustrated below with reference to specific examples.
Formulation example 1:21% permethrin-efficient cypermethrin wettable powder
1% Of permethrin, 20% of beta-cypermethrin, 4% of lignosulfonate, 6% of polycarboxylate, 3% of alkylphenol polyoxyethylene ether formaldehyde condensate sulfate, 20% of kieselguhr, 5% of secondary alkyl ammonium sulfate and 100% of kaolin.
The formula materials are uniformly mixed, crushed by an ultra-micro jet mill and then mixed to prepare the 21% permethrin-efficient cypermethrin wettable powder.
Formulation example 2:22% permethrin-efficient cypermethrin wettable powder
2% Of chlorpyrifos, 20% of high-efficiency cypermethrin, 8% of alkylphenol polyoxyethylene ether formaldehyde condensate, 1% of naphthalene sulfonate, 3% of sodium dodecyl sulfate, 25% of white carbon black, 10% of alkylsulfonyl chloride and 100% of kaolin.
The formula materials are uniformly mixed, crushed by an ultra-micro jet mill and then mixed to prepare 22% permethrin-efficient cypermethrin wettable powder.
Formulation example 3:18% permethrin-efficient cypermethrin wettable powder
3% Of permethrin, 15% of beta-cypermethrin, 2% of sulfate, 5% of alkylbenzene sulfonate calcium salt, 5% of alkylbenzene polyoxyethylene ether phosphate, 5% of polyalkylene glycol, 4% of vinyl acetate and 100% of corn starch.
The formula materials are uniformly mixed, crushed by an ultra-micro jet mill and then mixed to prepare the 18% permethrin-efficient cypermethrin wettable powder.
Formulation example 4:5% permethrin-efficient cypermethrin wettable powder
2.5% Of permethrin, 2.5% of high-efficiency cypermethrin, 6% of naphthalene sulfonic acid formaldehyde condensate sodium salt, 4% of phenethyl phenol polyoxyethylene ether phosphate, 5% of ethyl acrylate, 25% of bentonite and 100% of light calcium carbonate.
The formula materials are uniformly mixed, crushed by an ultra-micro jet mill and then mixed to prepare the 5% permethrin-efficient cypermethrin wettable powder.
Formulation example 5:30% permethrin-efficient cypermethrin wettable powder
25% Of chlorpyrifos, 5% of high-efficiency cypermethrin, 7% of alkylphenol ethoxylates, 2% of alkyl sulfate, 2% of alkyl sulfonate, 5% of polyacrylic acid, 5% of urea-formaldehyde resin and 100% of attapulgite.
The formula materials are uniformly mixed, crushed by an ultra-micro jet mill and then mixed to prepare 30% permethrin-efficient cypermethrin wettable powder.
Formulation example 6:27.5% permethrin-efficient cypermethrin wettable powder
25% Of chlorpyrifos, 2.5% of high-efficiency cypermethrin, 5% of fatty amine polyoxyethylene ether, 5% of fatty acid polyoxyethylene ester, 2% of nekal BX, 2% of dodecylbenzene sulfonic acid, 10% of secondary alkyl ammonium sulfate, 10% of bentonite and 100% of kaolin.
The formula materials are uniformly mixed, crushed by an ultra-micro jet mill and then mixed to prepare 27.5 percent of permethrin-efficient cypermethrin wettable powder.
Formulation example 7:21% permethrin-efficient cypermethrin wettable powder
20% Of chlorpyrifos, 1% of high-efficiency cypermethrin, 5% of fatty amine polyoxyethylene ether, 5% of fatty acid polyoxyethylene ester, 2% of nekal BX, 2% of dodecylbenzene sulfonic acid, 8% of urea-formaldehyde resin, 10% of bentonite and 100% of kaolin.
The formula materials are uniformly mixed, crushed by an ultra-micro jet mill and then mixed to prepare the 21% permethrin-efficient cypermethrin wettable powder.
Formulation example 8:42% permethrin-efficient cypermethrin water dispersible granule
2% Of permethrin, 40% of high-efficiency cypermethrin, 6% of lignosulfonate, 4% of naphthalene sulfonic acid formaldehyde condensate sodium salt, 5% of sodium dodecyl sulfate, 10% of sodium chloride, 0.5% of methyl cellulose, 10% of urea-formaldehyde resin and 100% of kaolin.
The formula materials are uniformly mixed, crushed by an ultra-micro jet mill, kneaded by adding a small amount of water, and then put into a rotary granulator for granulation and drying to obtain the 42% permethrin-efficient cypermethrin water dispersible granule.
Formulation example 9:33% permethrin-efficient cypermethrin water dispersible granule
3% Of permethrin, 30% of high-efficiency cypermethrin, 10% of alkylphenol polyoxyethylene ether formaldehyde condensate, 1% of alkyl sulfonate, 2% of nekal BX, 8% of ammonium chloride, 1% of polyvinylpyrrolidone, 4% of vinyl acetate, 6% of ethyl acrylate, 10% of white carbon black and 100% of corn starch.
The formula materials are uniformly mixed, crushed by an ultra-micro jet mill, kneaded by adding a small amount of water, and then put into a rotary granulator for granulation and drying to obtain the 33% permethrin-efficient cypermethrin water dispersible granule.
Formulation example 10:36% permethrin-efficient cypermethrin water dispersible granule
6% Of chlorpyrifos, 30% of high-efficiency cypermethrin, 9% of lignosulfonate, 4% of alkyl benzene polyoxyethylene ether phosphate, 9% of ammonium sulfate, 0.6% of polyvinyl alcohol, 9% of polyalkylene glycol and 100% of attapulgite.
The formula materials are uniformly mixed, crushed by an ultra-micro jet mill, kneaded by adding a small amount of water, and then put into a rotary granulator for granulation and drying to obtain the 36% permethrin-efficient cypermethrin water dispersible granule.
Formulation example 11:10% permethrin-efficient cypermethrin water dispersible granule
5% Of permethrin, 5% of high-efficiency cypermethrin, 5% of polycarboxylate, 3% of calcium salt of alkylbenzene sulfonate, 1% of dodecylbenzene sulfonic acid, 2% of sodium dodecyl sulfate, 10% of sodium carbonate, 0.1% of polyethylene glycol, 3% of alkylsulfonyl chloride, 3% of urea-formaldehyde resin and 100% of diatomite.
The formula materials are uniformly mixed, crushed by an ultra-micro jet mill, kneaded by adding a small amount of water, and then put into a rotary granulator for granulation and drying to obtain the 10% permethrin-efficient cypermethrin water dispersible granule.
Formulation example 12:18% permethrin-efficient cypermethrin water dispersible granule
15% Of permethrin, 3% of high-efficiency cypermethrin, 1% of alkylphenol polyoxyethylene ether formaldehyde condensate, 6% of polycarboxylate, 5% of alkyl sulfate, 6% of sodium bicarbonate, 0.5% of carboxymethyl cellulose, 7% of vinyl acetate, 20% of corn starch and 100% of attapulgite.
The formula materials are uniformly mixed, crushed by an ultra-micro jet mill, kneaded by adding a small amount of water, and then put into a rotary granulator for granulation and drying to obtain the 18% permethrin-efficient cypermethrin water dispersible granule.
Formulation example 13:50% permethrin-efficient cypermethrin water dispersible granule
45% Of permethrin, 5% of beta-cypermethrin, 5% of fatty acid polyoxyethylene ester, 4% of polycarboxylate, 5% of nekal BX, 10% of sodium sulfate, 0.2% of polyvinyl alcohol, 8% of alkylsulfonyl chloride and 100% of kaolin.
The formula materials are uniformly mixed, crushed by an ultra-micro jet mill, kneaded by adding a small amount of water, and then put into a rotary granulator for granulation and drying to prepare the 50% permethrin-efficient cypermethrin water dispersible granule.
Formulation example 14:42% permethrin-efficient cypermethrin water dispersible granule
40% Of permethrin, 2% of high-efficiency cypermethrin, 10% of lignosulfonate, 4% of sodium dodecyl sulfate, 5% of sodium sulfate, 0.3% of sodium carboxymethyl cellulose, 7% of ethyl acrylate and 100% of corn starch.
The formula materials are uniformly mixed, crushed by an ultra-micro jet mill, kneaded by adding a small amount of water, and then put into a rotary granulator for granulation and drying to obtain the 42% permethrin-efficient cypermethrin water dispersible granule.
Formulation example 15:10.5% permethrin-efficient cypermethrin suspending agent
0.5% Of chlorpyrithrin, 10% of beta-cypermethrin, 3% of glycerol fatty acid ester polyoxyethylene ether, 5% of polycarboxylate, 2% of alkyl benzene polyoxyethylene ether phosphate, 1% of naphthalene sulfonate, 0.2% of xanthan gum, 0.8% of magnesium aluminum silicate, 0.5% of potassium sorbate, 10% of ethylene glycol, 0.3% of cetyl alcohol, 6% of SP-SC3275 (belonging to cationic polycarboxylate copolymer, manufactured by Jiangsu qingyu chemical engineering Co., ltd.) and deionized water to 100%.
The formula materials are uniformly mixed and sanded by a sand mill until the particle size is less than 5 microns, and the 10.5% chlorpyrithrin-efficient cypermethrin suspending agent is prepared.
Formulation example 16:22% permethrin-efficient cypermethrin suspending agent
2% Of permethrin, 20% of beta-cypermethrin, 10% of fatty acid polyoxyethylene ester, 5% of alkylphenol polyoxyethylene ether formaldehyde condensate sulfate, 0.2% of xanthan gum, 0.5% of sodium alginate, 1% of sodium benzoate, 5% of propylene glycol, 0.1% of silicone oil, 4% of ethylene oxide-propylene oxide block polyether, 5% of polyacrylic acid and 100% of deionized water.
And uniformly mixing the formula materials, and sanding by a sand mill until the particle size is less than 5 microns to obtain the 22% permethrin-efficient cypermethrin suspending agent.
Formulation example 17:30% permethrin-efficient cypermethrin suspending agent
5% Of permethrin, 25% of high-efficiency cypermethrin, 1% of fatty amine polyoxyethylene ether, 5% of polycarboxylate, 2% of alkylbenzene polyoxyethylene ether phosphate, 3% of dodecylbenzene sulfonic acid, 0.1% of Arabic gum, 0.3% of pinus koraiensis, 5% of glycerol, 0.5% of distearyl ethylenediamine, 8% of ethylene oxide-propylene oxide block polyether and 100% of deionized water.
And uniformly mixing the formula materials, and sanding by a sand mill until the particle size is less than 5 microns to obtain the 30% permethrin-efficient cypermethrin suspending agent.
Formulation example 18:5% permethrin-efficient cypermethrin suspending agent
2.5% Of chlorpyrifos, 2.5% of high-efficiency cypermethrin, 5% of alkylphenol ethoxylates, 3% of lignosulfonate, 3% of phenethyl phenol polyoxyethylene ether phosphate, 0.3% of guar gum, 0.7% of magnesium aluminum silicate, 0.1% of benzisothiazolinone, 3% of urea, 0.5% of glycerol ricinoleate, 5% of polyalkylene glycol and 100% of deionized water.
And uniformly mixing the formula materials, and sanding by a sand mill until the particle size is less than 5 microns to prepare the 5% permethrin-efficient cypermethrin suspending agent.
Formulation example 19:9% permethrin-efficient cypermethrin suspending agent
7.5% Of chlorpyrifos, 1.5% of beta-cypermethrin, 10% of lignosulfonate, 4% of alkyl sulfate, 1% of naphthalene sulfonate, 0.3% of xanthan gum, 0.5% of potassium sorbate, 8% of propylene glycol, 0.3% of silicone oil, 5% of SP-SC3275 (belonging to cationic polycarboxylate copolymer, manufactured by Jiangsu Optimu chemical Co., ltd.), 3% of vinyl acetate and deionized water.
And uniformly mixing the formula materials, and sanding by a sand mill until the particle size is less than 5 microns to obtain the 9% permethrin-efficient cypermethrin suspending agent.
Formulation example 20:11% permethrin-efficient cypermethrin suspending agent
10% Of chlorpyrithrin, 1% of high-efficiency cypermethrin, 8% of naphthalene sulfonic acid formaldehyde condensate sodium salt, 3% of phenethyl phenol polyoxyethylene ether phosphate, 0.1% of sodium alginate, 0.5% of magnesium aluminum silicate, 0.1% of pinus koraiensis, 3% of ethylene glycol, 0.5% of tributyl phosphate, 3% of ethylene oxide-propylene oxide block polyether, 3% of alkylsulfonyl chloride and 100% of deionized water.
And uniformly mixing the formula materials, and sanding by a sand mill until the particle size is less than 5 microns to obtain the 11% permethrin-efficient cypermethrin suspending agent.
Formulation example 21:21% permethrin-efficient cypermethrin suspending agent
20% Of chloreneyne pyrethrin, 1% of high-efficiency cypermethrin, 2% of alkyl benzene sulfonic acid calcium salt, 6% of glycerin fatty acid ester polyoxyethylene ether, 5% of naphthalene sulfonate, 0.3% of xanthan gum, 0.2% of benzisothiazolinone, 4% of urea, 0.1% of silicone oil, 5% of ethylene oxide-propylene oxide block polyether, 5% of SP-SC3275 (belonging to cationic polycarboxylate copolymer, manufactured by Jiangsu qing chemical Co., ltd.) and 100% of deionized water.
And uniformly mixing the formula materials, and sanding by a sand mill until the particle size is less than 5 microns to obtain the 21% permethrin-efficient cypermethrin suspending agent.
Application example 1: indoor detention efficacy test for preventing and controlling mosquitoes and flies
Test target: female adults which are not bloodsucking after the light culex and the eclosion are on the 3 rd to the 5 th days;
housefly, adult on 3 rd to 4 th days after emergence, male and female are half;
the test method comprises the following steps: referring to GB/T13917.1-2009, a hold-up spray test;
Test treatment: the total concentration of the active ingredients in preparation examples 1, 5, 8, 12, 15 and 19 is diluted to 500mg/L;
Control 1:10% permethrin wettable powder is diluted to 500mg/L;
control 2:10% high-efficiency cypermethrin wettable powder is diluted to 500mg/L;
Test results:
table 1 formulation examples 1, 5, 8, 12, 15, 19 efficacy test against mosquitoes and flies
As can be seen from table 1, the knockdown effects of formulation examples 1, 5, 8, 12, 15, 19 on culex light and house fly were better than those of the control single-dose samples, and the mortality was better than that of the control single-dose samples. The permethrin and the high-efficiency cypermethrin have good control effect on culex light and houseflies by adopting a detention spraying mode.
Application example 2: efficacy test for preventing and treating cockroach indoor retention
Test target: german cockroach, adults of 10-15 days old, male and female half;
the test method comprises the following steps: referring to GB/T13917.1-2009, a hold-up spray test;
Test treatment: the total concentration of the active ingredients in preparation examples 2, 6, 9, 13, 18 and 20 is diluted to 500mg/L;
Control 1:10% permethrin wettable powder is diluted to 500mg/L;
control 2:10% high-efficiency cypermethrin wettable powder is diluted to 500mg/L;
Test results:
Table 2 formulation examples 2, 6, 9, 13, 18, 20 efficacy test against german cockroach
| Process name | Knock down rate of 0.5h | 1H knock down rate | 2H knock down rate | Mortality rate of 72h |
| Formulation example 2 | 50％ | 76.7％ | 100％ | 100％ |
| Formulation example 6 | 46.7％ | 73.3％ | 100％ | 100％ |
| Formulation example 9 | 50％ | 83.3％ | 100％ | 100％ |
| Formulation example 13 | 46.7％ | 80％ | 100％ | 100％ |
| Formulation example 18 | 43.3％ | 83.3％ | 100％ | 100％ |
| Formulation example 20 | 53.3％ | 86.7％ | 100％ | 100％ |
| Control 1 | 16.7％ | 36.7％ | 83.3％ | 83.3％ |
| Control sample 2 | 26.7％ | 40％ | 86.7％ | 86.7％ |
As shown in table 2, the preparation examples 2, 6, 9, 13, 18, 20 have obvious knockdown effect on german cockroaches at 0.5h, which is far better than the control samples 1 and 2, and the knockdown rate on german cockroaches at 2h is 100%, which is also better than the control samples 1 and 2; formulation examples 2, 6, 9, 13, 18, 20 had better 72h mortality for german cockroaches than control single dose samples. The permethrin and the high-efficiency cypermethrin have good control effect on the German cockroach by adopting a detention spraying mode.
Application example 3: indoor retention efficacy test for preventing and treating fleas
Test target: adult of 3-10 days old, female and male of the rat flea;
the test method comprises the following steps: referring to GB/T13917.1-2009, a hold-up spray test;
Test treatment: the total concentration of the active ingredients in preparation examples 3, 7, 10, 14, 19 and 21 is diluted to 500mg/L;
Control 1:10% permethrin wettable powder is diluted to 500mg/L;
control 2:10% high-efficiency cypermethrin wettable powder is diluted to 500mg/L;
Test results:
Table 3 formulation examples 3, 7, 10, 14, 19, 21 efficacy test against fleas from passion-by
As shown in table 3, the preparation examples 3, 7, 10, 14, 19 and 21 have obvious knockdown effect on the daphnia press at 0.5h, which is far better than the control samples 1 and 2, and the knockdown rates of the preparation examples 3, 7, 10, 14, 19 and 21 on the daphnia press at 1h are all 100% better than the control samples 1 and 2; formulation examples 3, 7, 10, 14, 19, 21 had better mortality to the print fleas for 24h than controls 1 and 2. The permethrin and the beta-cypermethrin have good control effect on the passion-by-rats by adopting a retention spraying mode.
Application example 4: three different absorption contact surface retention efficacy tests
Test target: female adults which are not bloodsucking after the light culex and the eclosion are on the 3 rd to the 5 th days;
housefly, adult on 3 rd to 4 th days after emergence, male and female are half;
German cockroach, adults of 10-15 days old, male and female half;
adult of 3-10 days old, female and male of the rat flea;
The test method comprises the following steps: referring to GB/T13917.1-2009, the retention spray test, tested once a 15 day test, was evaluated on the basis of a duration (d) of a mortality rate of greater than 70% for 24 hours (cockroach 72 h).
Test equipment board: non-absorbing surface-glass surface, duration > 90d rated A and duration > 60d rated B;
Semi-absorbing surface-clear paint surface, the duration is more than or equal to 60d and is rated as A grade, and the duration is more than or equal to 45d and is rated as B grade;
the absorption surface, the lime surface (mosquitoes, flies, fleas), the cement surface (cockroaches), is rated as A for a duration of more than or equal to 45d, and rated as B for a duration of more than or equal to 30 d;
Test treatment: the total concentration of the active ingredients in preparation examples 4, 11 and 18 is diluted to 500mg/L;
Control 1:10% permethrin wettable powder is diluted to 500mg/L;
control 2:10% high-efficiency cypermethrin wettable powder is diluted to 500mg/L;
Test results:
TABLE 4 test of retention efficacy of non-absorbing surfaces (glass surfaces) of formulations examples 4, 11 and 18
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TABLE 5 test of residual efficacy of semi-absorbent surfaces (varnish surfaces) of formulations examples 4, 11 and 18
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TABLE 6 test of retention efficacy of absorption surfaces (lime/Cement surfaces) of formulations examples 4, 11, 18
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From the test results in the table above, the formulations of the invention examples 4, 11, 18 were tested for culex light, house fly, german cockroach and print flea duration ratings all as class a, while a portion of the targets in the control group were of class B in three different absorption contact surface tests. The invention has better comprehensive control effect on three different targets with different absorption contact surfaces than the control group, and better detention effect than the control group.
Application example 5: outdoor efficacy comparison test for controlling flies
Test target: fly-fly
The test method comprises the following steps: selecting building walls and floors of farms as tested objects and partitioning, spraying medicaments on the surfaces of the walls and floors, and recording the density reduction rate of flies after 1 day, 2 days and 3 days of each treatment group;
Test treatment: formulation examples 2, 9 and 16 were diluted 100 times and the dosage was 20mg active ingredient/m 2;
control 3: commercially available 10% high-efficiency cyhalothrin wettable powder is diluted 100 times, and the dosage is 20mg of active ingredient/m 2;
Control 4: the commercial 6% beta-cypermethrin plus 4% propoxur suspending agent is diluted 100 times, and the dosage is 20mg of active ingredient/m 2;
Test results:
table 7 comparative test of efficacy of formulations examples 2, 9, 16 against flies outside the chamber
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The results show that the preparation examples 2, 9 and 16 have obvious fly control effect, the 1d density reduction rate is over 50 percent, and the 3d density reduction rate is over 95 percent, which are better than the control samples 3 and 4. The spraying mode of the permethrin and the beta-cypermethrin retention has good control effect.
Application example 6: storage experiment of permethrin and beta-cypermethrin compound preparation
The test method comprises the following steps: the prepared preparation is stored and observed at 54 ℃ for 14d and normal temperature
Test treatment: formulation examples 1, 8, 15;
Control 5: the stabilizer is removed and prepared according to the formulation of the preparation example 1;
Control 6: the stabilizer is removed and prepared according to the formulation of the preparation example 8;
control 7: the stabilizer was removed and formulated as formulation example 15;
Test results:
table 8 preparation examples 1, 8, 15 samples were observed at normal temperature
As shown in Table 8, the invention effectively solves the problems of heat storage and normal-temperature caking of wettable powder and water dispersible granules prepared from low-melting-point permethrin and beta-cypermethrin, crystallization and creaming prepared from suspending agents and the like by adding a high-molecular emulsifying dispersant; no stabilizer is added in the control samples 5,6 and 7, so that the problems of caking or crystallization and creaming at 54 ℃ and caking or crystallization and creaming after half a year of storage at normal temperature are solved. The preparation of the invention has no abnormality when observed for 2 years at normal temperature, and has good stability after 2 years of storage.
Application example 7: determination of co-toxicity coefficient of compound permethrin and beta-cypermethrin on culex light-colored mosquitoes
Test target: culex light color
The test method comprises the following steps: pesticide first part with reference to the in-house bioassay test criteria: touch-killing activity test, the activity determination test is carried out on culex light color by adopting a drop method NY/T1154.1-2006.
The data were subjected to linear weighted regression to calculate the half lethal dose LD 50 and the co-toxicity coefficient by reference to the grand cloud Peel method.
TABLE 9 determination of coerulence of permethrin and beta-cypermethrin (against culex light color)
As shown in table 9, the compounding ratio of permethrin to beta-cypermethrin is 1: 20-20: 1, the co-toxicity coefficients for culex pallidum are all more than 100, especially when the compounding ratio is 1: 10-10: when 1, the co-toxicity coefficient exceeds 120, and the synergistic effect is obvious.
The foregoing examples are merely illustrative of the technical concept and technical features of the present invention, and are not intended to limit the scope of the present invention. All equivalent changes or modifications made according to the essence of the present invention should be included in the scope of the present invention.
Claims (9)
1. The insecticidal composition containing the permethrin and the beta-cypermethrin is characterized by being prepared by compounding the permethrin and the beta-cypermethrin, wherein the weight ratio of the permethrin to the beta-cypermethrin is 1: 10-10: 1.
2. The insecticidal composition containing permethrin and beta-cypermethrin as described in claim 1, and a dispersing agent, a wetting agent, a stabilizing agent and a filler as raw materials, wherein the wettable powder is prepared from the insecticidal composition containing permethrin and beta-cypermethrin as described in claim 1, and is characterized in that: the percentages of the total weight of the wettable powder are as follows: 5 to 30 percent of insecticidal composition containing permethrin and beta-cypermethrin, 1 to 10 percent of dispersing agent, 1 to 5 percent of wetting agent, 5 to 10 percent of stabilizer and filler which are complemented to 100 percent.
3. The pesticide containing the permethrin and the beta-cypermethrin is a water dispersible granule prepared from the insecticidal composition containing the permethrin and the beta-cypermethrin, as well as a dispersing agent, a wetting agent, a disintegrating agent, a binder, a stabilizing agent and a filler which are used as raw materials, and is characterized in that: the weight percentages of the water dispersible granule are as follows: 10 to 50 percent of compound insecticidal composition containing permethrin and beta-cypermethrin, 1 to 10 percent of dispersing agent, 1 to 5 percent of wetting agent, 1 to 10 percent of disintegrating agent, 0.1 to 1 percent of binding agent, 5 to 10 percent of stabilizing agent and filling agent which are complemented to 100 percent.
4. The pesticide containing the permethrin and the beta-cypermethrin is a suspending agent prepared from the insecticidal composition containing the permethrin and the beta-cypermethrin, a dispersing agent, a wetting agent, a thickening agent, a preservative, an antifreezing agent, a defoaming agent, a stabilizing agent and deionized water as raw materials, and is characterized in that: the weight percentages of the suspending agents are as follows: 5 to 30 percent of compound insecticidal composition containing permethrin and beta-cypermethrin, 1 to 10 percent of dispersing agent, 1 to 5 percent of wetting agent, 0.1 to 1 percent of thickening agent, 0.1 to 1 percent of preservative, 3 to 10 percent of antifreezing agent, 0.1 to 0.5 percent of defoaming agent, 5 to 10 percent of stabilizing agent and deionized water which are complemented to 100 percent.
5. A pesticide according to any one of claims 2,3,4, wherein: the dispersing agent is selected from any one of polycarboxylate, lignosulfonate, alkylphenol polyoxyethylene ether formaldehyde condensate, sulfate, alkylbenzene sulfonate calcium salt, naphthalene sulfonate formaldehyde condensate sodium salt, alkylphenol polyoxyethylene ether, fatty amine polyoxyethylene ether, fatty acid polyoxyethylene ester and glycerin fatty acid ester polyoxyethylene ether, or a mixture of two or more of the above components in any proportion; the wetting agent is selected from any one of alkylphenol polyoxyethylene ether formaldehyde condensate sulfate, alkylbenzene polyoxyethylene ether phosphate, phenethyl phenol polyoxyethylene ether phosphate, alkyl sulfate, alkyl sulfonate, naphthalene sulfonate, sodium dodecyl sulfate, nekal BX and dodecylbenzene sulfonic acid, or a mixture of two or more of the above components in any proportion; the stabilizer is selected from any one or a mixture of any two of secondary alkyl ammonium sulfate, alkyl sulfonyl chloride, urea-formaldehyde resin, polyalkylene glycol, polyacrylic acid, ethylene oxide-propylene oxide block polyether, vinyl acetate, ethyl acrylate and SP-SC3275 according to any proportion.
6. A pesticide according to any one of claims 2 and 3, wherein: the filler is selected from any one of kaolin, white carbon black, corn starch, attapulgite, light calcium carbonate, diatomite and bentonite, or a mixture of two or more of the above materials in any proportion.
7. A pesticide according to claim 3, wherein: the disintegrating agent is selected from any one of sodium chloride, ammonium sulfate, sodium carbonate, sodium bicarbonate and sodium sulfate; the binder is selected from any one of methylcellulose, polyvinylpyrrolidone, polyvinyl alcohol, polyethylene glycol and sodium carboxymethyl cellulose.
8. The insecticide of claim 4, wherein: the thickener is selected from one of xanthan gum, sodium alginate, aluminum magnesium silicate, acacia and guar gum, or a mixture of two or more of the above materials at any ratio; the preservative is selected from any one of potassium sorbate, sodium benzoate, pinocembrane and benzisothiazolinone; the antifreezing agent is selected from any one of ethylene glycol, propylene glycol, glycerol and urea; the defoamer is selected from any one of distearyl ethylenediamine, tributyl phosphate, silicone oil, cetyl alcohol and glycerol ricinoleate.
9. Use of a pesticide comprising permethrin and lambda-cyhalothrin according to any one of claims 2, 3 and 4 for controlling public health pests, namely mosquitoes, flies, cockroaches and fleas, in places of application including hotels, schools, factories, families, farmers, farms and public places; the pesticide containing the permethrin and the beta-cypermethrin is applied in a detention spraying mode when preventing and controlling public health pests, the wettable powder is diluted by 100-200 times with water, the water dispersible granule is diluted by 100-200 times with water, and the suspending agent is diluted by 100-200 times with water and then sprayed on walls, doors, windows, ceilings and household surfaces.
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| CN107027802A (en) * | 2017-05-16 | 2017-08-11 | 郭秦 | A kind of cholrempenthrin fumicants |
| CN112056322A (en) * | 2019-06-11 | 2020-12-11 | 江苏功成生物科技有限公司 | Sanitary insecticidal composition containing chlorenthrin and application thereof |
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