CN114870236B - Microneedle needle insertion device based on pneumatic loading - Google Patents
Microneedle needle insertion device based on pneumatic loading Download PDFInfo
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- CN114870236B CN114870236B CN202210294807.5A CN202210294807A CN114870236B CN 114870236 B CN114870236 B CN 114870236B CN 202210294807 A CN202210294807 A CN 202210294807A CN 114870236 B CN114870236 B CN 114870236B
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- pressure
- air inlet
- relief valve
- pressure head
- inlet channel
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- 238000003780 insertion Methods 0.000 title description 3
- 230000037431 insertion Effects 0.000 title description 3
- 230000000149 penetrating effect Effects 0.000 claims abstract description 4
- 230000003139 buffering effect Effects 0.000 claims description 3
- 239000003086 colorant Substances 0.000 claims description 3
- 239000000696 magnetic material Substances 0.000 claims description 3
- 238000000034 method Methods 0.000 description 5
- 230000000694 effects Effects 0.000 description 4
- 208000005171 Dysmenorrhea Diseases 0.000 description 2
- 206010013935 Dysmenorrhoea Diseases 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000013271 transdermal drug delivery Methods 0.000 description 2
- 241001391944 Commicarpus scandens Species 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 238000010030 laminating Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000002344 surface layer Substances 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0061—Methods for using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/10—General characteristics of the apparatus with powered movement mechanisms
Abstract
A microneedle needle feeder based on pneumatic loading comprises a hard pressure head, wherein a pressure chamber is arranged in the pressure head, and one end of the pressure head facing the skin of a human body is taken as the lower end; the lower end of the pressure head is connected with an inflatable air bag, and the inner cavity of the air bag is communicated with the pressure chamber of the pressure head; the air bag expands downwards when expanding, so that the microneedle patch is pressed into the skin surface; the pressure head is provided with a pressure relief valve and a safety valve respectively at two sides of the upper part of the pressure head, and the upper end of the pressure head is connected with an organism; the center of the machine body is provided with a penetrating air inlet channel, and the two sides of the air inlet channel are respectively provided with a left cavity and a right cavity; an air inlet channel of the engine body is communicated with an inner cavity of the pressure head, and a throttle valve for controlling the air flow cross section area in the air inlet channel is arranged in the air inlet channel; the throttle valve is arranged on a throttle valve shaft, and two ends of the throttle valve shaft are rotatably arranged on the inner wall of the air inlet channel; an electromagnet and a sliding block are arranged in the right chamber, and a control mechanism and a power supply are arranged in the left chamber. The invention can realize automatic needle stepping with controllable needle inserting force and speed.
Description
Technical Field
The invention relates to the technical field of medical instruments, in particular to a microneedle injector based on pneumatic loading.
Background
The micro needle is a novel percutaneous administration carrier, and the micro needle has the clear characteristic of fine size, so that the micro needle can deliver medicines to a human body on the surface layer of skin without touching subcutaneous nerves, thereby enabling the percutaneous administration without dysmenorrhea to be possible.
In order to deliver sufficient amounts of drug to the human body, researchers often use microneedle patches as carriers for drug delivery without dysmenorrhea; because the micro-needle is fine in size and complex in mechanical property on the surface of human skin, the micro-needle is extremely easy to break and deform in the process of percutaneous administration, and resistance is increased for popularization of the micro-needle patch due to the occurrence of the conditions; in order to achieve good transdermal drug delivery effect, the microneedle patch needs to be penetrated into the skin with proper strength and speed, and the radian of the skin can lead to uneven stress of the microneedle patch, and the uneven stress can affect the penetration angle of local microneedles.
The existing microneedle patch injector can control the needle inserting force and time, but most of the existing microneedle patch injector does not consider the problem of uneven stress of the microneedle patch caused by skin radian, and the existing microneedle injector mostly adopts manual needle inserting, so that the existing microneedle patch injector which can control the force and the speed and can be simultaneously pushed needs to be developed.
Disclosure of Invention
In order to overcome the problems, the invention provides a microneedle injector based on pneumatic loading.
The technical scheme adopted by the invention is as follows: a microneedle needle feeder based on pneumatic loading comprises a hard pressure head, wherein a pressure chamber is arranged in the pressure head, and one end of the pressure head facing the skin of a human body is taken as the lower end; the lower end of the pressure head is connected with an inflatable air bag, and the inner cavity of the air bag is communicated with the pressure chamber of the pressure head; the air bag expands downwards when expanding, so that the microneedle patch is pressed into the skin surface;
The pressure head is provided with a pressure relief valve and a safety valve respectively at two sides of the upper part of the pressure head, and the upper end of the pressure head is connected with an organism; the center of the machine body is provided with a penetrating air inlet channel, and the two sides of the air inlet channel are respectively provided with a left cavity and a right cavity; an air inlet channel of the engine body is communicated with an inner cavity of the pressure head, and a throttle valve for controlling the air flow cross section area in the air inlet channel is arranged in the air inlet channel; the shape of the throttle valve is matched with the cross section shape of the air inlet channel, and the throttle valve is arranged on the throttle valve shaft; a pair of mounting holes are formed in the front side and the rear side of the air inlet channel, and a long slot hole communicated with the right cavity is formed in the rear side of the air inlet channel; the rear end head of the throttle shaft is rotatably arranged in the mounting hole at the rear side, the rear end of the throttle shaft is hinged with the left end of the throttle connecting rod, and the front end head of the throttle shaft is rotatably arranged in the mounting hole at the front side; the right end of the throttle valve connecting rod passes through the long slot hole and is hinged with the left end of the slide block connecting rod, and the right end of the slide block connecting rod is hinged with the rear side of the slide block;
The sliding block is made of magnetic materials, is arranged in the right cavity in a sliding manner, and springs are connected with the bottom surface of the sliding block and the right cavity; an electromagnet is arranged in the right cavity and above the sliding block, and a gasket for buffering is arranged on the bottom surface of the electromagnet; after the electromagnet is electrified, the electromagnet and the sliding block attract each other to enable the sliding block to be close to the electromagnet; after the electromagnet is powered off, the sliding block is far away from the electromagnet under the action of the spring; the reciprocating linear motion of the sliding block is converted into rotary motion of the throttle valve around the throttle shaft through the sliding block connecting rod and the throttle valve connecting rod, and the air flow cross section area in the air inlet channel is controlled, so that the pressurizing speed in the pressure chamber is controlled;
The bottom in the left cavity is provided with a control mechanism, a power supply is arranged in the left cavity and above the control mechanism, and the outer wall surface of the left cavity is provided with an indicator lamp and a starting switch; the power supply is electrically connected with the control mechanism, the output end of the control mechanism is respectively connected with the indicator lamp and the electromagnetic iron, and the output end of the starting switch is electrically connected with the input end of the control mechanism; the starting switch outputs different signals to the control mechanism according to the long press and the short press, and the short press time control mechanism controls the display color of the indicator lamp according to the electric quantity of the power supply; the long-time pressing control mechanism controls the electromagnet to be electrified or powered off, and controls the indicator lamp to display different colors according to preset pressing time;
The upper end of the machine body is provided with a rear cover, the rear cover is provided with an air inlet interface communicated with the air inlet channel, and the air inlet interface is connected with an external air pump; the rear cover is provided with a screw hole communicated with the right cavity, the outer wall of the upper part of the electromagnet is provided with external threads matched with the screw hole, and the upper end of the electromagnet penetrates out of the rear cover and is in threaded connection with the screw hole.
Further, the pressure relief valve comprises a pressure relief valve body, and the upper end and the lower end of the pressure relief valve body are respectively connected with the tail part of the pressure relief valve and the head part of the pressure relief valve to form an I-shaped structure; an inlet communicated with the pressure chamber is formed in the pressure relief valve body, and an outlet communicated with the outside atmosphere is formed in the tail part of the pressure relief valve body; the wall surface of the pressure head is provided with a through hole, a pressure relief valve body is arranged in the through hole, the head part of the pressure relief valve is positioned in the pressure chamber, the tail part of the pressure relief valve is positioned outside the pressure head, and a pressure relief valve spring is sleeved on the pressure relief valve body and positioned between the pressure head and the tail part of the pressure relief valve; when the pressure release valve spring is in a natural state, the pressure release valve head part seals the through hole; when the pressure release valve spring is in a compressed state, an inlet on the pressure release valve body is communicated with the pressure chamber, so that the pressure in the pressure chamber is released.
Further, the safety valve comprises a piston and a safety valve spring, a mounting hole which does not penetrate through the outer surface of the pressure head is formed in the wall surface of the pressure chamber, the piston and the safety valve spring are arranged in the mounting hole, and two ends of the safety valve spring are respectively connected with the piston and the bottom of the mounting hole; the two sides of the mounting hole are provided with pressure relief holes communicated with the pressure chamber, and the wall surface of the pressure chamber is provided with pressure relief channels communicated with the pressure relief holes and the external atmosphere; the piston is subjected to pressure in the pressure chamber to move outwards and compress the safety valve spring until the pressure relief hole on the pressure head is communicated with the pressure chamber, so that the pressure in the pressure chamber is relieved.
Further, the balloon is spherically downward hemispherical when inflated.
The beneficial effects of the invention are as follows:
(1) This microneedle needle feeder can realize automatic needle feeding through the inflation of gasbag, and the gasbag adopts hemisphere flexible membrane, and the gasbag warp and to release pressure release laminating skin profile before the pressurization, then unclamp the relief valve, and then the gasbag is then locked at the space state that reflects skin profile by atmospheric pressure this moment, so each part of microneedle paster can be advanced simultaneously by the gasbag of inflation, reaches good percutaneous and doses the effect.
(2) When the radian, hardness, thickness and other properties of the skin are changed, the force and the speed required by the microneedle patch to be pressed in are also changed; the opening of the throttle valve can be changed to control the pressurizing speed in the pressure chamber, so that the force and the speed of the air bag pressing the microneedle patch can be controlled;
(3) When the air pressure in the pressure chamber exceeds the safety pressure, the safety valve transmits the exceeded medium to the atmosphere, so that the pressure is reduced to a normal value, and the reliability and safety of the product are improved.
Drawings
Fig. 1 is a cross-sectional view of the present invention prior to use.
Fig. 2 is a cross-sectional view of the invention in use.
FIG. 3 is a schematic diagram of a connection structure of a slider and a throttle valve according to the present invention.
Fig. 4 is a perspective assembly schematic of the present invention.
Fig. 5 is a schematic structural view of the safety valve in the present invention.
Fig. 6 is a schematic structural diagram of a relief valve according to the present invention.
Detailed Description
The following description of the embodiments of the present invention will be made more apparent and fully hereinafter with reference to the accompanying drawings, in which some, but not all embodiments of the invention are shown. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
In the description of the present invention, it should be noted that, as the terms "center," "upper," "lower," "left," "right," "vertical," "horizontal," "inner," "outer," and the like are used for convenience in describing the present invention and simplifying the description based on the azimuth or positional relationship shown in the drawings, it should not be construed as limiting the present invention, but rather should indicate or imply that the devices or elements referred to must have a specific azimuth, be constructed and operated in a specific azimuth. Furthermore, the terms "first," "second," "third," and the like, as used herein, are used for descriptive purposes only and are not to be construed as indicating or implying any relative importance.
In the description of the present invention, it should be noted that unless explicitly stated and limited otherwise, the terms "mounted," "connected," and "connected" should be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communication between two elements. The specific meaning of the above terms in the present invention will be understood in specific cases by those of ordinary skill in the art.
Referring to the drawings, after the air outlet of the air pump is connected, the microneedle patch can be pressed into skin by using the air pressure of the air pump to achieve a good microneedle percutaneous administration effect. The microneedle injector comprises a hard pressure head 1, wherein a pressure chamber 2 is arranged in the pressure head 1, the pressure chamber 2 is a chamber with constant volume, and one end of the pressure head 1 facing the skin of a human body is taken as the lower end;
The lower end of the pressure head 1 is connected with an inflatable air bag 3, and the inner cavity of the air bag 3 is communicated with the pressure chamber 2 of the pressure head 1; the air bag 3 is a hemispherical flexible film, can be attached to the outline of the skin surface, and when the air pressure in the pressure chamber 2 acts, the air bag 3 has a tendency to recover a round shape due to the air pressure, so that the microneedle patch is pressed into the skin surface.
The upper end of the pressure head 1 is connected with an organism 15, and a pressure relief valve 5 and a safety valve 4 are respectively arranged on two sides of the upper part of the pressure head 1; the center of the machine body 15 is provided with a penetrating air inlet channel 11, and two sides of the air inlet channel 11 are respectively provided with a left cavity and a right cavity; an air inlet channel 11 of the engine body 15 is communicated with the inner cavity of the pressure head 1, and a throttle valve 14 for controlling the air flow cross section area in the air inlet channel 11 is arranged in the air inlet channel 11; the shape of the throttle valve 14 is matched with the cross-sectional shape of the air inlet channel 11, and the throttle valve 14 is arranged on a throttle shaft; a pair of mounting holes are formed in the front side and the rear side of the air inlet channel 11, and a long slot hole communicated with the right cavity is formed in the rear side of the air inlet channel 11; the rear end of the throttle shaft is rotatably arranged in the mounting hole at the rear side, the rear end of the throttle shaft is hinged with the left end of the throttle connecting rod 163, and the front end of the throttle shaft is rotatably arranged in the mounting hole at the front side; the right end of the throttle valve connecting rod 163 is hinged with the left end of the slide block connecting rod 162 through a long slot, and the right end of the slide block connecting rod 162 is hinged with the rear side of the slide block 161;
The sliding block 161 is made of magnetic materials, the sliding block 161 is arranged in the right cavity in a sliding way, and springs 17 are connected with the bottom surface of the sliding block 161 and the inside of the right cavity; an electromagnet 12 is arranged in the right cavity and above the sliding block, and a gasket 13 for buffering is arranged on the bottom surface of the electromagnet 12; after the electromagnet 12 is electrified, the electromagnet 12 attracts the sliding block 161 to enable the sliding block 161 to be close to the electromagnet 12; after the electromagnet 12 is powered off, the sliding block 161 is far away from the electromagnet 12 under the action of the spring 17; the reciprocating linear motion of the slider 161 is converted into rotational motion of the throttle valve 14 about the throttle shaft through the slider link 162 and the throttle link 163, and the air flow cross-sectional area in the air intake duct 11 is controlled, thereby controlling the pressurizing speed in the pressure chamber 2;
The bottom in the left cavity is provided with a control mechanism 6, a power supply 7 is arranged in the left cavity and above the control mechanism 6, and the outer wall surface of the left cavity is provided with an indicator lamp 8 and a starting switch 9; the power supply 7 is electrically connected with the control mechanism 6, and the power supply 7 supplies power to the control mechanism 6, the indicator lamp 8 and the electromagnet 12; the output end of the control mechanism 6 is electrically connected with the indicator lamp 8 and the electromagnet 12 respectively, and the output end of the starting switch 9 is electrically connected with the input end of the control mechanism 6; the starting switch 9 outputs different signals to the control mechanism 6 according to the long press and the short press, and the short press control mechanism 6 controls the display color of the indicator lamp 8 according to the electric quantity of the power supply 7; the long-time pressing control mechanism 6 controls the electromagnet 12 to be electrified or powered off, and controls the indicator lamp 8 to display different colors according to preset pressing time; specifically, the indicator lamp 8 comprises a yellow lamp, a green lamp and a red lamp, and when the start switch 9 is pressed for a short time to enable the microneedle insertion device to be in a starting state, the indicator lamp 8 lights the yellow lamp; when the electric quantity of the power supply 7 is insufficient or before full charge, the indicator lamp 8 lights a red lamp, a green lamp is not lighted until the power supply 7 is full charge, the charging wire is pulled out, and the indicator lamp displays a yellow lamp (namely, a normal starting state); when the starting switch 9 is pressed for a long time, the electromagnet 12 is electrified, the pressing time reaches the preset time of the control mechanism 6, and the starting switch 9 is still in a pressing state at the moment, the indicator lamp 8 is changed from a yellow lamp to a green lamp, the starting switch 9 is released after the user observes that the green lamp is on, the electromagnet is powered off, and meanwhile, the indicator lamp 8 is changed into the yellow lamp, so that the end of the micro-needle patch pressing process is indicated.
The upper end of the machine body 15 is provided with a rear cover 10, the rear cover 10 is provided with an air inlet interface 101 communicated with the air inlet channel 11, and the air inlet interface 101 is connected with an external air pump; the rear cover 10 is provided with a screw hole communicated with the right cavity, the outer wall of the upper part of the electromagnet 12 is provided with external threads matched with the screw hole, and the upper end of the electromagnet 12 penetrates out of the rear cover 10 and is in threaded connection with the screw hole. Therefore, the electromagnet 12 can feed into the cavity of the machine body 15 by virtue of the screw thread at the upper end, so that the distance between the electromagnet 12 and the sliding block 161 is changed, and the rotation angle of the throttle valve 14 is also changed, namely the opening degree of the throttle valve 14 can be controlled.
In this embodiment, the relief valve 5 includes a relief valve body, and the upper and lower ends of the relief valve body are respectively connected with a relief valve tail 51 and a relief valve head 53 to form an i-shaped structure; an inlet 54 communicated with the pressure chamber 2 is formed in the pressure relief valve body, and an outlet communicated with the external atmosphere is formed in the tail part 51 of the pressure relief valve; a through hole is formed in the wall surface of the pressure head 1, a pressure relief valve body is arranged in the through hole, a pressure relief valve head 53 is positioned in the pressure chamber 2, a pressure relief valve tail 51 is positioned outside the pressure head 1, and a pressure relief valve spring 52 is sleeved on the pressure relief valve body and positioned between the pressure head 1 and the pressure relief valve tail 51; when the relief valve spring 52 is in a natural state, the relief valve head 53 closes the through hole; when the relief valve spring 52 is in a compressed state, an inlet 54 in the relief valve body communicates with the pressure chamber 2, thereby releasing the pressure in the pressure chamber 2.
In this embodiment, the safety valve 4 includes a piston 43 and a safety valve spring 42, a wall surface of the pressure chamber 2 is provided with a mounting hole which does not penetrate through an outer surface of the pressure head 1, the mounting hole is internally provided with the piston 43 and the safety valve spring 42, and two ends of the safety valve spring 42 are respectively connected with the piston 43 and a bottom of the mounting hole; the two sides of the mounting hole are provided with pressure relief holes 41 communicated with the pressure chamber 2, and the wall surface of the pressure head 1 is provided with pressure relief channels communicated with the pressure relief holes 41 and the external atmosphere; the piston 43 is moved outwards by the pressure in the pressure chamber 2 and compresses the relief valve spring 42 until the relief hole 41 in the ram 1 communicates with the pressure chamber 2, thereby releasing the pressure in the pressure chamber 2.
Before the invention is used, the air outlet of the air pump with set pressure is connected to the air inlet port 101 on the back cover 10 of the machine body, and the microneedle patch is also attached to the target skin;
when in use: firstly, a user holds the machine body 15 by both hands and presses down the pressure release valve 5, and the pressure chamber 2 is communicated with the atmosphere at the moment, so that the air bag 3 can freely compress the air in the air bag, and the machine body 15 is vertically close to the skin at the moment, so that the air bag 3 deforms and is attached to the skin contour, and then the pressure release valve 5 is released, and the air bag 3 is locked in a space state reflecting the skin contour by air pressure at the moment;
Step two, the start switch 9 is pressed for a short time, and the indicator lamp 8 is lightened to indicate starting; when the start switch 9 is pressed for a long time, the control mechanism 6 starts timing, meanwhile, the electromagnet 12 is also powered on, the sliding block 161 is attracted by magnetic force and collides against the gasket 13 at the head of the electromagnet 12, meanwhile, the sliding block connecting rod 162 and the throttle valve connecting rod 163 drive the throttle valve 14 to rotate, the air pressure in the air inlet channel 11 rapidly pressurizes the pressure chamber 2 to the preset air pressure, the air bag 3 is pressed against the micro-needle patch at a certain pressure and speed, and the micro-needle on the micro-needle patch is pressed into the skin for administration. When the pressing-in time reaches 1 or 2 seconds, the control mechanism 6 considers that the percutaneous administration of the microneedle patch is successful, so as to send a green light-on instruction to the indicator lamp 8, when a user observes that the green light is on, the indicator lamp 8 turns into a yellow lamp, the electromagnet 12 loses magnetic force due to power failure, the sliding block 161 returns to the original position due to the elastic force of the spring 17, meanwhile, the connecting rod 162 drives the air throttle 14 to cut off the connection between the air inlet channel 11 and the pressure chamber 2, the user can remove the pneumatic microneedle needle feeder from the skin, finally, the pressure release valve 5 is pressed again, the air pressure in the pressure chamber 2 is restored to the standard atmospheric pressure, and the pressing-in process is finished.
In the pressing-in process of the embodiment, if the air pressure in the pressure chamber 2 exceeds the safety pressure, the safety valve 4 plays a role in protection; specifically, when the pressure in the pressure chamber 2 is applied, the piston 43 moves toward the inside of the passage and compresses the relief valve spring 42, when the applied pressure exceeds a predetermined relief pressure, the piston 43 moves to the rear of the relief hole 41, and at this time, the pressure chamber 2 is vented to the atmosphere, until the pressure in the pressure chamber 2 drops below the predetermined relief pressure, and the piston 43 cuts off the communication between the relief hole 41 and the pressure chamber 2 due to the elastic force of the relief valve spring 42.
In the pressing-in process of the present embodiment, if it is desired to unload the pressure in the pressure chamber 2, the pressure relief action of the relief valve 5 is relied on at this time; specifically, the relief valve 5 is a hollow i-shaped component, the relief valve head 53 is located inside the pressure chamber 2, the relief valve tail 51 is located outside the pressure head rear portion 1, the middle of the relief valve body is sleeved with the compressed relief valve spring 52, one end of the relief valve spring 52 is located on the outer wall of the pressure head rear portion 1, and the other end of the relief valve spring 52 is propped against the relief valve tail 51, so that the relief valve 5 is in a normally closed state, and the circular relief hole 54 of the relief valve head 53 is communicated with the pressure chamber 2 only when the relief valve tail 51 is pressed from the outside, so that the air pressure in the pressure chamber 2 is released.
If the physical characteristics of the skin change, namely the radian, hardness, thickness and other properties of the skin change, the force and the speed required by the microneedle patch to be pressed in also change; in order to achieve good transdermal drug delivery effect, the invention can control the pressurizing speed in the pressure chamber 2 by changing the opening degree of the throttle valve 14, thereby controlling the force and speed of the air bag 3 pressing the microneedle patch; specifically, the electromagnet 12 is connected with the machine body rear cover 10 through the threads, and the feeding amount of the electromagnet 12 to the inside of the cavity of the machine body 15 is controlled, so that the free displacement stroke of the sliding block 161 is changed, and the opening degree of the throttle valve 14 is changed along with the movement conversion of the connecting rod 162, so that the pressurizing speed of the pressure chamber 2, namely the pressing speed of the air bag 3, is also controlled.
The embodiments described in the present specification are merely examples of implementation forms of the inventive concept, and the scope of protection of the present invention should not be construed as being limited to the specific forms set forth in the embodiments, and the scope of protection of the present invention and equivalent technical means that can be conceived by those skilled in the art based on the inventive concept.
Claims (4)
1. A microneedle injector based on pneumatic loading, characterized in that: comprises a hard pressure head (1), wherein a pressure chamber (2) is arranged in the pressure head (1), and one end of the pressure head (1) facing the skin of a human body is taken as the lower end; the lower end of the pressure head (1) is connected with an inflatable air bag (3), and the inner cavity of the air bag (3) is communicated with the pressure chamber (2) of the pressure head (1); the air bag (3) expands downwards when expanding, so that the microneedle patch is pressed into the skin surface;
The two sides of the upper part of the pressure head (1) are respectively provided with a pressure relief valve (5) and a safety valve (4), and the upper end of the pressure head (1) is connected with an organism (15); the center of the machine body (15) is provided with a penetrating air inlet channel (11), and the two sides of the air inlet channel (11) are respectively provided with a left cavity and a right cavity; an air inlet channel (11) of the engine body (15) is communicated with the inner cavity of the pressure head (1), and a throttle valve (14) for controlling the air flow cross section area in the air inlet channel (11) is arranged in the air inlet channel (11); the shape of the throttle valve (14) is matched with the cross section shape of the air inlet channel (11), and the throttle valve (14) is arranged on a throttle shaft; a pair of mounting holes are formed in the front side and the rear side in the air inlet channel (11), and a long slot hole communicated with the right cavity is formed in the rear side in the air inlet channel (11); the rear end of the throttle shaft is rotatably arranged in the mounting hole at the rear side, the rear end of the throttle shaft is hinged with the left end of the throttle connecting rod (163), and the front end of the throttle shaft is rotatably arranged in the mounting hole at the front side; the right end of the throttle valve connecting rod (163) is hinged with the left end of the sliding block connecting rod (162) through a long slot, and the right end of the sliding block connecting rod (162) is hinged with the rear side of the sliding block (161);
The sliding block (161) is made of magnetic materials, the sliding block (161) is arranged in the right cavity in a sliding way, and springs (17) are connected with the bottom surface of the sliding block (161) and the right cavity; an electromagnet (12) is arranged in the right cavity and above the sliding block, and a gasket (13) for buffering is arranged on the bottom surface of the electromagnet (12); after the electromagnet (12) is electrified, the electromagnet (12) and the sliding block (161) attract each other to enable the sliding block (161) to approach the electromagnet (12); after the electromagnet (12) is powered off, the sliding block (161) is far away from the electromagnet (12) under the action of the spring (17); the reciprocating linear motion of the sliding block (161) is converted into rotary motion of the throttle valve (14) around a throttle shaft through a sliding block connecting rod (162) and a throttle valve connecting rod (163), and the air flow cross section area in the air inlet channel (11) is controlled, so that the pressurizing speed in the pressure chamber (2) is controlled;
The bottom in the left cavity is provided with a control mechanism (6), a power supply (7) is arranged in the left cavity and above the control mechanism (6), and the outer wall surface of the left cavity is provided with an indicator lamp (8) and a starting switch (9); the power supply (7) is electrically connected with the control mechanism (6), the output end of the control mechanism (6) is electrically connected with the indicator lamp (8) and the electromagnet (12) respectively, and the output end of the starting switch (9) is electrically connected with the input end of the control mechanism (6); the starting switch (9) outputs different signals to the control mechanism (6) according to the long press and the short press, and the short press control mechanism (6) controls the display color of the indicator lamp (8) according to the electric quantity of the power supply (7); the long-time pressing control mechanism (6) controls the electromagnet (12) to be electrified or powered off, and controls the indicator lamp (8) to display different colors according to preset pressing time;
The upper end of the machine body (15) is provided with a rear cover (10), the rear cover (10) is provided with an air inlet interface (101) communicated with the air inlet channel (11), and the air inlet interface (101) is connected with an external air pump; the rear cover (10) is provided with a screw hole communicated with the right cavity, the outer wall of the upper part of the electromagnet (12) is provided with external threads matched with the screw hole, and the upper end of the electromagnet (12) penetrates out of the rear cover (10) and is in threaded connection with the screw hole.
2. A pneumatically loaded microneedle injector as defined in claim 1, wherein: the pressure relief valve (5) comprises a pressure relief valve body, and the upper end and the lower end of the pressure relief valve body are respectively connected with the tail part (51) and the head part (53) of the pressure relief valve to form an I-shaped structure; an inlet (54) communicated with the pressure chamber (2) is formed in the pressure relief valve body, and an outlet communicated with the external atmosphere is formed in the tail part (51) of the pressure relief valve; the pressure head is characterized in that a through hole is formed in the wall surface of the pressure head (1), a pressure relief valve body is arranged in the through hole, a pressure relief valve head (53) is positioned in the pressure chamber (2), a pressure relief valve tail (51) is positioned outside the pressure head (1), and a pressure relief valve spring (52) is sleeved on the pressure relief valve body and positioned between the pressure head (1) and the pressure relief valve tail (51); when the pressure relief valve spring (52) is in a natural state, the pressure relief valve head (53) closes the through hole; when the relief valve spring (52) is in a compressed state, an inlet (54) on the relief valve body communicates with the pressure chamber (2) to relieve pressure in the pressure chamber (2).
3. A pneumatically loaded microneedle injector as defined in claim 1, wherein: the safety valve (4) comprises a piston (43) and a safety valve spring (42), a mounting hole which does not penetrate through the outer surface of the pressure head (1) is formed in the wall surface of the pressure chamber (2), the piston (43) and the safety valve spring (42) are arranged in the mounting hole, and two ends of the safety valve spring (42) are respectively connected with the piston (43) and the bottom of the mounting hole; the two sides of the mounting hole are provided with pressure relief holes (41) communicated with the pressure chamber (2), and the wall surface of the pressure chamber (2) is provided with pressure relief channels communicated with the pressure relief holes (41) and the external atmosphere; the piston (43) is moved outwards by the pressure in the pressure chamber (2) and compresses the safety valve spring (42) until the pressure relief hole (41) on the pressure head (1) is communicated with the pressure chamber (2), so that the pressure in the pressure chamber (2) is relieved.
4. A pneumatically loaded microneedle injector as defined in claim 1, wherein: the balloon (3) is in a hemispherical shape with a spherical surface downwards when being inflated.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210294807.5A CN114870236B (en) | 2022-03-23 | 2022-03-23 | Microneedle needle insertion device based on pneumatic loading |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202210294807.5A CN114870236B (en) | 2022-03-23 | 2022-03-23 | Microneedle needle insertion device based on pneumatic loading |
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| CN114870236B true CN114870236B (en) | 2024-05-03 |
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|---|---|---|---|---|
| JP2011078711A (en) * | 2009-10-05 | 2011-04-21 | Kosumedei Seiyaku Kk | Microneedle array administration device using magnetic repulsion |
| CN213158932U (en) * | 2020-04-24 | 2021-05-11 | 优微（珠海）生物科技有限公司 | Soluble microneedle introduction device |
| CN214050172U (en) * | 2020-09-28 | 2021-08-27 | 杭州整形医院有限公司 | Microneedle auxiliary material device |
| KR102309710B1 (en) * | 2021-04-20 | 2021-10-08 | 주식회사 테라젝아시아 | Syringe type microneedle |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002330083A1 (en) * | 2001-09-21 | 2003-04-01 | Biovalve Technologies, Inc. | Gas pressure actuated microneedle arrays, and systems and methods relating to same |
| US8328757B2 (en) * | 2010-01-08 | 2012-12-11 | Wisconsin Alumni Research Foundation | Bladder arrangement for microneedle-based drug delivery device |
| DE102019200563A1 (en) * | 2019-01-17 | 2020-07-23 | Lts Lohmann Therapie-Systeme Ag | Applicator |
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- 2022-03-23 CN CN202210294807.5A patent/CN114870236B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011078711A (en) * | 2009-10-05 | 2011-04-21 | Kosumedei Seiyaku Kk | Microneedle array administration device using magnetic repulsion |
| CN213158932U (en) * | 2020-04-24 | 2021-05-11 | 优微（珠海）生物科技有限公司 | Soluble microneedle introduction device |
| CN214050172U (en) * | 2020-09-28 | 2021-08-27 | 杭州整形医院有限公司 | Microneedle auxiliary material device |
| KR102309710B1 (en) * | 2021-04-20 | 2021-10-08 | 주식회사 테라젝아시아 | Syringe type microneedle |
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