CN114868839A - 一种用于围产前期奶牛的杜仲叶组合物及其制备方法和应用 - Google Patents
一种用于围产前期奶牛的杜仲叶组合物及其制备方法和应用 Download PDFInfo
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- CN114868839A CN114868839A CN202210446408.6A CN202210446408A CN114868839A CN 114868839 A CN114868839 A CN 114868839A CN 202210446408 A CN202210446408 A CN 202210446408A CN 114868839 A CN114868839 A CN 114868839A
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- eucommia ulmoides
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- 241000283690 Bos taurus Species 0.000 title claims abstract description 129
- 230000009984 peri-natal effect Effects 0.000 title claims abstract description 99
- 241000208689 Eucommia ulmoides Species 0.000 title claims abstract description 60
- 239000000203 mixture Substances 0.000 title claims abstract description 56
- 238000002360 preparation method Methods 0.000 title abstract description 7
- 235000013365 dairy product Nutrition 0.000 claims abstract description 59
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- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims abstract description 22
- 235000021050 feed intake Nutrition 0.000 claims abstract description 20
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- DRCWOKJLSQUJPZ-DZGCQCFKSA-N (4ar,9as)-n-ethyl-1,4,9,9a-tetrahydrofluoren-4a-amine Chemical compound C1C2=CC=CC=C2[C@]2(NCC)[C@H]1CC=CC2 DRCWOKJLSQUJPZ-DZGCQCFKSA-N 0.000 claims abstract description 11
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- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims description 20
- 150000002576 ketones Chemical class 0.000 claims description 11
- 102000004877 Insulin Human genes 0.000 claims description 10
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- 229940125396 insulin Drugs 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 9
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- 238000012360 testing method Methods 0.000 description 58
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- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 7
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- 208000035240 Disease Resistance Diseases 0.000 description 3
- 239000012467 final product Substances 0.000 description 3
- 208000007976 Ketosis Diseases 0.000 description 2
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- 229920000084 Gum arabic Polymers 0.000 description 1
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- 241000304387 Phedimus kamtschaticus Species 0.000 description 1
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- 239000000205 acacia gum Substances 0.000 description 1
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- 230000037406 food intake Effects 0.000 description 1
- 230000004153 glucose metabolism Effects 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 230000005802 health problem Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- -1 iridoids Natural products 0.000 description 1
- 210000004153 islets of langerhan Anatomy 0.000 description 1
- 229930013686 lignan Natural products 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/10—Feeding-stuffs specially adapted for particular animals for ruminants
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/174—Vitamins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/02—Algae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/46—Eucommiaceae (Eucommia family), e.g. hardy rubber tree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
- Y02P60/80—Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
- Y02P60/87—Re-use of by-products of food processing for fodder production
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Polymers & Plastics (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Botany (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Animal Husbandry (AREA)
- Food Science & Technology (AREA)
- Zoology (AREA)
- Endocrinology (AREA)
- Birds (AREA)
- Reproductive Health (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Physiology (AREA)
- Feed For Specific Animals (AREA)
- Fodder In General (AREA)
Abstract
Description
组别 | 添加量 | 头数 | 饲喂天数 | 距离产犊 | 平均胎次 |
试验组1 | 0.1kg/头 | 200 | 28 | 28 | 2胎 |
试验组2 | 0.3kg/头 | 200 | 28 | 28 | 3胎 |
试验组3 | 0.6kg/头 | 200 | 28 | 28 | 2胎 |
试验组4 | 0.7kg/头 | 200 | 28 | 28 | 2胎 |
对照组1 | 牧场原配方日粮 | 200 | 28 | 28 | 2胎 |
对照组2 | 瘤胃胆碱40克/头 | 150 | 28 | 28 | 2胎 |
组别 | 7d |
试验组1 | 1.10 |
试验组2 | 0.90 |
试验组3 | 0.70 |
试验组4 | 1.50 |
对照组1 | 1.10 |
对照组2 | 0.90 |
组别 | 胎衣不下(%) | 瘫痪(%) | 变胃(%) | 子宫炎(%) | 乳房炎(%) |
试验组1 | 2.8 | 2.6 | 1.5 | 1.2 | 0.0 |
试验组2 | 2.1 | 1.2 | 0.5 | 0.5 | 0.0 |
试验组3 | 1.0 | 0.0 | 0.0 | 0.5 | 0.0 |
试验组4 | 4.0 | 4.5 | 3.5 | 1.9 | 0.0 |
对照组1 | 3.2 | 3.5 | 4.8 | 4.5 | 0.0 |
对照组2 | 2.2 | 0.8 | 0.7 | 1.7 | 0.0 |
组别 | 5d | 10d | 15d | 21d· | 均值 |
试验组1 | 7.20 | 12.20 | 14.50 | 15.50 | 12.35 |
试验组2 | 7.50 | 15.50 | 17.50 | 17.80 | 14.58 |
试验组3 | 8.00 | 16.00 | 17.80 | 18.00 | 14.95 |
试验组4 | 4.50 | 8.50 | 12.00 | 15.50 | 10.13 |
对照组1 | 5.00 | 12.00 | 15.00 | 17.00 | 12.25 |
对照组2 | 7.40 | 14.00 | 16.80 | 17.80 | 14.00 |
Claims (10)
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CN202210446408.6A CN114868839B (zh) | 2022-04-26 | 2022-04-26 | 一种用于围产前期奶牛的杜仲叶组合物及其制备方法和应用 |
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CN202210446408.6A CN114868839B (zh) | 2022-04-26 | 2022-04-26 | 一种用于围产前期奶牛的杜仲叶组合物及其制备方法和应用 |
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Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011076155A1 (en) * | 2009-12-22 | 2011-06-30 | Irel, Spol. S R.O. | Feed supplement based on milk thistle, method of its production and its use |
CN113439804A (zh) * | 2020-03-24 | 2021-09-28 | 内蒙古优然牧业有限责任公司 | 一种用于泌乳后期肥胖奶牛的绞股蓝组合物及其制备方法和应用 |
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2022
- 2022-04-26 CN CN202210446408.6A patent/CN114868839B/zh active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011076155A1 (en) * | 2009-12-22 | 2011-06-30 | Irel, Spol. S R.O. | Feed supplement based on milk thistle, method of its production and its use |
CN113439804A (zh) * | 2020-03-24 | 2021-09-28 | 内蒙古优然牧业有限责任公司 | 一种用于泌乳后期肥胖奶牛的绞股蓝组合物及其制备方法和应用 |
Non-Patent Citations (4)
Title |
---|
TENG, ZW ET.AL: "Metabolomic and Lipidomic Approaches to Evaluate the Effects of Eucommia ulmoides Leaves on Milk Quality and Biochemical Properties", 《FRONTIERS IN VETERINARY SCIENCE》, 1 June 2021 (2021-06-01), pages 1 - 12 * |
张延利等: "日粮添加海藻对奶牛产奶性能的影响", 《中国奶牛》, pages 15 - 18 * |
高素敏: "杜仲叶对奶牛生产性能影响的研究", 《中国乳业》, pages 40 - 41 * |
魏筱诗: "烟酰胺对围产期奶畜糖脂代谢及其子代肠道发育的影响和机制", 《中国优秀博士论文全文数据库 农业科技辑》, pages 050 - 8 * |
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