CN114859030A - Sample detection device - Google Patents

Sample detection device Download PDF

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Publication number
CN114859030A
CN114859030A CN202210352054.9A CN202210352054A CN114859030A CN 114859030 A CN114859030 A CN 114859030A CN 202210352054 A CN202210352054 A CN 202210352054A CN 114859030 A CN114859030 A CN 114859030A
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China
Prior art keywords
sample
reagent card
reagent
tube
sample tube
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CN202210352054.9A
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Chinese (zh)
Inventor
廖闽
陆锋
秦军芳
蒋庭彦
易奇浩
翟留伟
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Shenzhen Dymind Biotechnology Co Ltd
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Shenzhen Dymind Biotechnology Co Ltd
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Priority to CN202210352054.9A priority Critical patent/CN114859030A/en
Publication of CN114859030A publication Critical patent/CN114859030A/en
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5302Apparatus specially adapted for immunological test procedures
    • G01N33/5304Reaction vessels, e.g. agglutination plates
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

The application discloses a sample detection device, which comprises a sample tube storage unit, a reagent card reaction unit and a collection unit; the sample tube storage unit is used for storing the sample tube and moving the sample tube to the sample adding position; the reagent card storage unit is used for storing a plurality of reagent cards and moving the reagent cards to the sample adding position; the reagent card reaction unit is used for storing a reagent card added with a tested sample and moving the reagent card from the sample adding position to the collecting position, wherein the moving distance of the reagent card from the sample adding position to the collecting position is greater than the linear distance from the sample adding position to the collecting position; the acquisition unit is used for acquiring the result of the reagent card to obtain detection data. By the mode, the volume of the reagent card reaction unit can be reduced, the volume of the sample detection device is reduced, miniaturization is realized, and the device is suitable for various scenes.

Description

Sample detection device
Technical Field
The application relates to the technical field of respiratory infectious diseases, in particular to a sample detection device.
Background
The existing sample detection devices are used for antigen-antibody detection of samples, wherein the antigen-antibody detection methods include a variety of detection techniques, such as precipitation reaction, enzyme-linked immunoassay, radioimmunoassay, fluorescence immunoassay, luminescence immunoassay, and the like.
In order to realize high-throughput detection, the conventional sample detection device is large in size.
Disclosure of Invention
In order to solve the above problems, the present application provides a sample detection device including:
the device comprises a sample tube storage unit, a reagent card reaction unit and a collection unit; the sample tube storage unit is used for storing a sample tube and moving the sample tube to a sample adding position, and the sample tube stores a detected sample; the reagent card storage unit is used for storing a plurality of reagent cards and moving the reagent cards to the sample adding position so that the tested samples of the sample tubes can be in contact with the reagent cards; the reagent card reaction unit is used for storing a reagent card added with the tested sample and moving the reagent card added with the tested sample from the sample adding position to a collecting position, wherein the moving distance of the reagent card from the sample adding position to the collecting position is larger than the linear distance from the sample adding position to the collecting position; the acquisition unit is used for acquiring the result of the reagent card to obtain detection data.
The reagent cards are arranged in a sheet shape, and the reagent cards added with the tested samples are stacked on each other along the thickness direction of the reagent cards in the reagent card reaction unit.
The reagent card reaction unit comprises an annular rotating belt and a plurality of containers arranged at intervals along the circumferential direction of the annular rotating belt, and after the reagent cards are placed in one container, the thickness direction of the reagent cards points to other adjacent containers.
The reagent card storage unit comprises a first reagent card loading mechanism, the first reagent card loading mechanism transfers the reagent cards stored in the reagent card storage unit into the sample adding position along a first direction, and the axial direction of the annular rotating belt is arranged along the first direction.
When the first reagent card loading mechanism drives the reagent card, the thickness direction of the reagent card is arranged along a second direction perpendicular to the first direction, the reagent card reaction unit comprises a second reagent card loading mechanism, and the second reagent card loading mechanism overturns the reagent card to enable the thickness direction of the reagent card to be arranged along a third direction perpendicular to the first direction and the second direction and transfers the reagent card into the container along the first direction.
Wherein the first direction and the third direction are horizontal directions, and the second direction is a vertical direction.
The reagent card storage unit comprises a first reagent cassette, a first reagent card loading mechanism and a reagent card conveying mechanism, wherein the first reagent cassette and the first reagent card loading mechanism are arranged on one side of the reagent card conveying mechanism, the first reagent cassette stores the reagent cards in a stacking mode, and the first reagent card loading mechanism transfers the reagent cards into the reagent card conveying mechanism and conveys the reagent cards to the sample adding position through the reagent card conveying mechanism; the reagent card reaction unit comprises a second reagent card box and a second reagent card loading mechanism, the second reagent card box and the second reagent card loading mechanism are arranged on the other side of the reagent card conveying mechanism, the first reagent card loading mechanism passes through the reagent card conveying mechanism to transfer the reagent card added with the tested sample into the second reagent card box, and the second reagent card box stores the reagent card in a stacking mode.
The reagent card reaction unit forms a bent transmission path, and the reagent card added with the measured sample is transmitted to the collection position along the bent transmission path.
The sample detection device further comprises a feeding mechanism, wherein the feeding mechanism is arranged at the sample adding position and is used for extruding the sample tube so as to ensure that the detected sample of the sample tube is dripped on the reagent card.
The sample detection device further comprises a feeding mechanism, the feeding mechanism is arranged at the sample adding position, the reagent card is fed into the sample tube by the feeding mechanism, and the reagent card reaction unit is further used for storing the sample tube into which the reagent card is fed.
The sample tube storage unit comprises a sample tube storage mechanism, a sample tube conveying mechanism and a sample tube loading mechanism, wherein the sample tube storage mechanism is used for storing the sample tube, the sample tube conveying mechanism forms a conveying path between the sample tube storage mechanism and the sample adding position, the sample tube loading mechanism is provided with a moving path, the conveying path and the moving path form a first intersection position and a second intersection position, and the sample tube loading mechanism is used for loading the sample tube stored by the sample tube storage mechanism on the sample tube conveying mechanism at the first intersection position and unloading the sample tube from the sample tube conveying mechanism at the second intersection position.
The sample tube loading mechanism comprises a rotating arm and a hand grip, the hand grip is arranged at one end of the rotating arm and used for loading or unloading the sample tube, and the rotating arm rotates around a set rotating center.
Wherein, the sample detection device further comprises a negative pressure disinfection mechanism, and the negative pressure disinfection mechanism is used for carrying out negative pressure disinfection on the sample adding position.
The sample tube comprises a tube body and a self-sealing cover body, wherein the self-sealing cover body is kept sealed in a natural state and can be opened after the tube body is extruded.
The sample tube further comprises a stop piece, and the stop piece is used for stopping a sampling tool placed in the tube body to act on the self-sealing cover body under the action of gravity.
The stop piece is a filter screen arranged on one side of the opening of the self-sealing cover body facing the bottom of the pipe body; or the stop piece is a convex rib which is arranged around the opening of the self-sealing cover body and extends towards the bottom of the tube body.
The self-sealing cover body is an elastic body and is provided with a self-sealing cut; or, the self-sealing cover body comprises a main body part, an elastic part and a piston, wherein the main body part forms a channel for communicating with the tube body, the piston seals the channel under the elastic support of the elastic part in a natural state, and when the internal pressure of the tube body is increased, the piston overcomes the elastic support of the elastic part to open the channel.
Wherein the sample detection device further comprises: the information acquisition unit is used for acquiring personal information of the testee; the processing unit is used for recording the position information of the sample tube storing the tested sample, which is placed in the sample tube storing unit; the processing unit is further used for recording binding information after the personal information is associated with the position information.
The application provides a sample detection device, which comprises a sample tube storage unit, a reagent card reaction unit and a collection unit; the sample tube storage unit is used for storing the sample tube and moving the sample tube to the sample adding position; the reagent card storage unit is used for storing a plurality of reagent cards and moving the reagent cards to the sample adding position so that the tested sample of the sample tube can be contacted with the reagent cards; the reagent card reaction unit is used for storing the reagent card added with the detected sample and moving the reagent card added with the detected sample from the sample adding position to the collecting position, wherein the moving distance of the reagent card from the sample adding position to the collecting position is larger than the linear distance from the sample adding position to the collecting position; the acquisition unit is used for acquiring the result of the reagent card to obtain detection data. The reagent card in the reagent card reaction unit is arranged to move from the sample adding position to the collecting position by a distance which is larger than the linear distance from the sample adding position to the collecting position, so that the volume of the reagent card reaction unit can be reduced, the volume of the sample detection device is reduced, the miniaturization is realized, and the reagent card reaction unit is suitable for various scenes.
Drawings
In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings needed to be used in the description of the embodiments are briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present application, and it is obvious for those skilled in the art to obtain other drawings based on these drawings without creative efforts. Wherein:
FIG. 1 is a schematic structural view of a first embodiment of a sample testing device according to the present application;
FIG. 2 is a schematic structural view of a second embodiment of the sample testing device of the present application;
FIG. 3 is a schematic diagram of the structure of a first embodiment of the reagent card reaction unit of FIG. 2;
FIG. 4 is a schematic view of the reagent cartridge of FIG. 2;
FIG. 5 is a schematic structural view of a third embodiment of the sample testing device of the present application;
FIG. 6 is a schematic view of a fourth embodiment of a sample testing device provided herein;
FIG. 7 is a schematic view of a sixth embodiment of a sample testing device provided herein;
FIG. 8 is a schematic structural view of a sixth embodiment of a sample testing device according to the present application;
FIG. 9 is a schematic diagram of the structure of the sample tube and reagent card of FIG. 8;
FIG. 10 is a schematic block diagram of a seventh embodiment of a sample testing device according to the present application;
FIG. 11 is a schematic structural view of a first embodiment of a sample tube of the present application;
FIG. 12 is a schematic structural view of a second embodiment of the sample tube of the present application;
FIG. 13 is a schematic structural view of a third embodiment of the sample tube of the present application;
FIG. 14 is a schematic structural view of a fourth embodiment of the sample tube of the present application;
FIG. 15 is a schematic cross-sectional view of the sample tube of FIG. 14;
FIG. 16 is a schematic structural view of a fifth embodiment of the sample tube of the present application;
fig. 17 is a schematic cross-sectional view of the sample tube of fig. 16.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be obtained by a person skilled in the art without inventive work based on the embodiments of the present invention, are within the scope of the present invention.
It should be noted that, if directional indications (such as up, down, left, right, front, and back … …) are involved in the embodiment of the present invention, the directional indications are only used to explain the relative positional relationship between the components, the movement situation, and the like in a specific posture (as shown in the drawing), and if the specific posture is changed, the directional indications are changed accordingly.
In addition, if there is a description of "first", "second", etc. in an embodiment of the present invention, the description of "first", "second", etc. is for descriptive purposes only and is not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one such feature. In addition, technical solutions between various embodiments may be combined with each other, but must be realized by a person skilled in the art, and when the technical solutions are contradictory or cannot be realized, such a combination should not be considered to exist, and is not within the protection scope of the present invention.
Referring to fig. 1, fig. 1 is a schematic diagram of a first embodiment of a sample testing device according to the present application. The sample testing device 10 of the present embodiment includes a sample tube storage unit 11, a reagent card storage unit 12, a reagent card reaction unit 13, and a collection unit 14. The sample detection device 10 can be used for antigen-antibody detection of a sample to be detected. The sample detection device 10 can be applied to detection of antigens of respiratory infectious diseases, which are infectious diseases caused by invasion of pathogens from respiratory infections such as nasal cavities, throats, tracheas, and bronchi of human bodies. By measuring the corresponding antigen, the degree of reaction between the antigen and the corresponding reagent is known, so that whether the measured person has the corresponding antigen or not is obtained. It should be understood that the sample testing device 10 is only used for the determination of the type of antigen and is not involved in the diagnosis and treatment of the corresponding disease, not the use for diagnostic purposes.
The sample tube storage unit 11 is used for storing a sample tube, and moving the sample tube to the sample adding position, and the sample tube stores a sample to be measured. The reagent card storage unit 12 is used for storing a plurality of reagent cards and moving the reagent cards to the sample adding position, so that the tested samples of the sample tube can contact with the reagent cards, namely the tested samples of the sample tube are injected into the reagent cards, and the sample adding of the reagent cards is realized. Before the sample is applied to the reagent card, the sample detection device 10 can shake up the sample to be detected in the sample tube.
The reagent card reaction unit 13 is used for storing the reagent card added with the detected sample and moving the reagent card added with the detected sample from the sample adding position to the collecting position, wherein the moving distance of the reagent card from the sample adding position to the collecting position is greater than the linear distance from the sample adding position to the collecting position; the collecting unit 14 is used for collecting the result of the reagent card positioned on the collecting position to obtain detection data. The acquisition unit 14 may be an image acquisition mechanism for acquiring a picture of the result of the reagent card to obtain the detection data.
The sample tube is provided with identification information, the identification information can be a bar code, a label or a two-dimensional code, for example, a bar code is pasted in a bar code area of the sample tube. Optionally, the sample tube storage unit 11 includes a sample tube scanning mechanism for reading a barcode region of the sample tube to obtain the identification information of the sample tube.
The sample detection device 10 has a sample adding position and a collecting position, the sample detection device 10 is used for adding a sample to be detected of a sample tube into a reagent card at the sample adding position, and the collecting unit 14 is used for collecting a result of the reagent card positioned on the collecting position. The sample tube includes, but is not limited to, pharyngeal swab, nasal swab, saliva, body fluid, and the like.
After the tested sample in the sample tube is added into the reagent card, the tested sample reacts on the reagent card to obtain the reaction time. The reagent card reaction unit 13 is used for storing the reagent card to which the sample to be measured is added, that is, the reagent card in the reagent card reaction unit 13 performs a reaction, for example, the reagent card is located in the reagent card reaction unit 13 during the reaction time.
In this embodiment, the moving distance of the reagent card from the sample application site to the collection site is set to be greater than the linear distance from the sample application site to the collection site, that is, the shape of the moving path of the reagent card from the sample application site to the collection site may be, but is not limited to, circular, S-shaped, C-shaped, spiral, oval, or arcuate. Therefore, the reaction time between the sample to be detected and the reagent card is sufficient, and the accuracy of the sample detection device 10 is improved. Moreover, the arrangement mode realizes the storage of a large number of reagent cards in a small area, has high integration degree, meets the use requirement of high flux and is favorable for the miniaturization of the volume of the whole device.
The reagent card of sample detection device 10 of this embodiment is greater than the straight-line distance of application of sample position to collection position from the distance of removal of application of sample position to collection position, reduces reagent card reaction unit 13's volume, reduces sample detection device 10's volume, realizes miniaturizedly, is applicable to multiple scene, for example sample detection device 10 can set up in places such as community, basic unit medical field, railway station, subway, can satisfy the scene that the flow of people is big.
Referring to FIGS. 2-3, FIG. 2 is a schematic structural diagram of a second embodiment of a sample testing device according to the present application;
FIG. 3 is a schematic diagram of the structure of a first embodiment of the reagent card reaction unit of FIG. 2.
The sample test device 20 of the present embodiment includes a sample tube storage unit 21, a reagent card storage unit 22, a reagent card reaction unit 23, and a collection unit 24. The reagent card 221 stored in the reagent card storage unit 22 is provided in a sheet form. Optionally, the reagent card 221 is provided with a sample addition hole to add a sample to be measured to the reagent card 221 through the sample addition hole.
The reagent card reaction unit 23 includes an endless rotating belt 232 and a plurality of containers 233, the plurality of containers 233 being arranged at intervals along a circumferential direction of the endless rotating belt 232; the receptacle 233 is used to hold the reagent card 221.
After the reagent card 221 is placed in one of the receptacles 233, the thickness direction of the reagent card 221 is directed to the other receptacles 233 adjacent thereto; that is, the reagent cards 221 in the container 233 are vertically placed on the endless rotating belt 232, so that the area of the endless rotating belt 232 occupied by the reagent cards 221 is reduced, and the number of the reagent cards 221 placed in the endless rotating belt 232 is increased, so that the sample testing device 20 can meet the requirement of high-throughput testing, for example, the sample testing device 20 can complete testing of 500 tested samples in one hour. Wherein the thickness direction of the reagent card 221 is arranged substantially parallel to the driving direction of the endless rotary belt 232. Substantially parallel indicates that the two directions are perfectly parallel or have a deviation within a tolerable range without affecting a reliable transmission.
Optionally, the receptacle 233 is provided as a frame or basket with an opening to facilitate insertion of the reagent card 221 into the receptacle 233 or ejection from the receptacle 233.
Because the containers 233 are arranged at intervals along the circumferential direction of the endless rotating belt 232, the distance between any two adjacent containers 233 in the plurality of containers 233 is a preset value, so as to prevent the two adjacent containers 233 from abutting against each other and affecting the normal operation of the endless rotating belt 231; furthermore, it is also convenient to place the reagent card 221 in a certain receptacle 233.
Specifically, the plurality of test sample-added reagent cards 221 are placed in the corresponding receptacles 233, so that the plurality of test sample-added reagent cards 221 are stacked on the endless rotating belt 232 in the thickness direction of the reagent cards 221, that is, the test sample-added reagent cards 221 are stacked on the reagent card storage unit 23 in the thickness direction of the reagent cards 221, thereby reducing the area of the endless rotating belt 232 occupied by the reagent cards 221.
The reagent card reaction unit 23 of the present embodiment includes an annular rotary belt 232 and a plurality of containers 233, and after the reagent card 221 is placed in one container 233, the thickness direction of the reagent card 221 points to the other adjacent containers 233, so as to reduce the area of the annular rotary belt 232 occupied by the reagent card 221, and thus the sample detection device 20 can realize high throughput detection.
As shown in fig. 2 and 3, the reagent card storage unit 22 includes a first reagent card loading mechanism 222, the first reagent card loading mechanism 222 transfers the reagent card 221 stored in the reagent card storage unit 22 to the sample application site along the first direction x, and the axial direction of the endless rotary belt 232 is arranged along the first direction x.
The reagent card storage unit 22 is configured to store the reagent card 221 without the sample to be tested, and the first reagent card loading mechanism 222 is located on a side of the reagent card 221 away from the sample loading position, so that the first reagent card loading mechanism 222 transfers the reagent card 221 to the sample loading position. For example, the first reagent card loading mechanism 222 is an ejection mechanism.
When the first reagent card loading mechanism 222 moves the reagent card 221, the thickness direction of the reagent card 221 is arranged in a second direction perpendicular to the first direction x, that is, the thickness direction of the reagent card 221 is arranged parallel to the second direction.
As shown in fig. 2 and 3, the reagent card reaction unit 23 includes a second reagent card loading mechanism 231, and the second reagent card loading mechanism 231 turns over the reagent card 221 to which the sample to be measured has been applied such that the thickness direction of the reagent card 221 is arranged in a third direction y perpendicular to the first direction x and the second direction. The second reagent card loading mechanism 231 transfers the reagent card 221 into the receptacle 233 in the first direction x so that the reagent card 221 stands on the endless rotary belt 232. For example, the second reagent card loading mechanism 231 is a jack-up mechanism for inverting the reagent card 221 that is lying flat into the reagent card 221 that is standing upright.
Optionally, the first direction x and the third direction y are horizontal directions, and the second direction is a vertical direction. Because the axial of the annular rotating belt 232 is arranged along the first direction x, the annular rotating belt 232 is vertically placed on the sample detection device 20, so that the annular rotating belt 232 forms an upper annular rotating belt 232 and a lower annular rotating belt 232, the space is further saved, the volume occupied by the reagent card reaction unit 23 is reduced, the volume of the sample detection device 20 is reduced, the miniaturization is realized, and the device is suitable for various scenes.
Optionally, the endless rotating belt 232 is provided with an entrance position where the standing reagent cards 221 are transferred into the receptacle 233 and an exit position where the standing reagent cards 221 are pushed out of the receptacle 233. Further, the endless rotating belt 232 includes, but is not limited to, a flat belt type transmission belt, a synchronous belt type transmission belt, or a chain type transmission belt. The endless rotary belt 232 includes a driving pulley and a driven pulley for driving the endless rotary belt 232 to drive the container 233.
Alternatively, as shown in fig. 2 and 3, the reagent card reaction unit 23 includes a first belt 234 and a first pushing mechanism 235, and the first belt 234 is disposed adjacent to the endless rotary belt 232 and between the endless rotary belt 232 and the sample application site. The first reagent card loading mechanism 222 is configured to move the reagent card 221 loaded with the sample to be tested from the sample loading position to one end of the first conveyer 234 close to the sample loading position, the second reagent card loading mechanism 231 is located at the other end of the first conveyer 234 away from the sample loading position, and the first conveyer 234 is configured to move the reagent card 221 to the second reagent card loading mechanism 231, so that the second reagent card loading mechanism 231 turns the reagent card 221 from a flat placement to a side-standing placement.
The first pushing mechanism 235 is disposed on a side of the first belt 234 away from the entrance position of the endless rotating belt 232, and is configured to transfer the vertically disposed reagent card 221 into the entrance position of the endless rotating belt 232, so as to place the vertically disposed reagent card 221 into the receptacle 233.
Alternatively, the sum of the first number of the reagent cards 221 on the first belt 234 and the second number of the reagent cards 221 on the endless rotary belt 232 is a total number, and the total number of the reagent cards is multiplied by the moving time of each reagent card 221 to be equal to the reaction time, so that the reagent cards 221 to which the sample to be measured has been added are completely reacted in the reagent card reaction unit 23, and the volumes of the first belt 234 and the endless rotary belt 232 are reduced, thereby further reducing the volume of the reagent card reaction unit 23.
Alternatively, as shown in fig. 2 and 3, the sample tube storage unit 21 includes a transmission mechanism 211, an introduction mechanism 212, and an unloading mechanism 213, the introduction mechanism 212 includes a plurality of sample holders 214, the sample holders 214 are used for placing sample tubes 215, for example, one sample holder 214 can place 5 sample tubes 215 or 10 sample tubes 215, so that the sample tube storage unit 21 stores the sample tubes 215. The driving mechanism 211 is used to move the sample tube 215 on the sample rack 214 to the loading position, and after the sample tube 215 injects the sample to be tested into the reagent card 221, the driving mechanism 211 moves the sample tube 215 on the sample rack 214 to the unloading mechanism 213, so that the unloading mechanism 213 unloads the sample tube 215 on the sample rack 214.
Alternatively, as shown in fig. 2 and 3, the reagent card reaction unit 23 includes a second pushing structure 236, a second belt 237 and a leveling mechanism 238, the second pushing structure 236 is used for pushing the reagent card 221 located at the outlet position of the endless rotating belt 232 out to the second belt 237, the leveling mechanism 238 is used for leveling the reagent card 221 on the second belt 237, and the second belt 237 is used for moving the reagent card 221 to the collecting position, so that the collecting unit 24 is used for collecting the result of the reagent card 221 to obtain the detection data; the second belt 237 is used to move the collected reagent card 221 to a waste bin.
The reagent card 221 of this embodiment passes through the first driving belt 234, the annular rotating belt 232 and the second driving belt 237 from the sample addition position to the collection position, and therefore the moving distance of the reagent card 221 from the sample addition position to the collection position is greater than the linear distance from the sample addition position to the collection position, the volume occupied by the reagent card reaction unit 23 is reduced, the volume of the sample detection device 20 is reduced, miniaturization is realized, and the reagent card is suitable for various scenes.
Optionally, the sample detection device 20 includes a negative pressure sterilization mechanism, and the negative pressure sterilization mechanism is configured to at least suck the gas at the sample application position, collect and sterilize the gas uniformly, so as to prevent the sample detection device 20 from generating a risk of leakage of aerosol pollution, and improve the safety of the sample detection device 20 in use.
Optionally, the sample testing device 20 further includes an ultraviolet lamp disinfection mechanism, and the ultraviolet lamp disinfection mechanism is configured to disinfect an ultraviolet lamp after the sample testing device 20 completes testing of the tested samples of all the tested persons.
Optionally, as shown in fig. 2 and 3, the sample tube storage unit 21 further includes a scanning mechanism 216 for scanning a barcode region of the sample tube 215 to read the identification information of the sample tube 215. The sample detection device 20 obtains the position information of the sample tube 215 on the sample rack 214, and binds the identification information with the position information of the sample tube 215 on the sample rack 214; the sample testing device 20 also binds the position information of the sample tube 215 on the sample rack 214 with the position information of the corresponding reagent card 221 on the reagent storage unit 22, thereby binding the reagent card 221 with the identification information. In other embodiments, the reagent card 221 is provided with a reagent card identifier, and the sample detection device 20 is configured to bind the reagent card identifier with the identification information.
Optionally, the sample detection device 20 further comprises a dosing mechanism. The dropping mechanism is disposed at the sample adding position, and the dropping mechanism is configured to press the sample tube 215, so that the sample to be measured of the sample tube 215 is dropped on the sample adding hole of the reagent card 221.
Alternatively, as shown in fig. 4, the reagent card storage unit 22 includes a reagent cassette 223, the reagent cassette 223 including a plurality of reagent cards 221, the plurality of reagent cards 221 being stored in a stacked manner. The first reagent card loading mechanism 222 is used for moving the reagent card 221 at the bottom of the reagent cassette 223 to the loading position, and the other reagent cards 221 in the reagent cassette 223 fall down by gravity. In addition, the housing of the reagent cartridge 223 is provided with vents to facilitate dry storage.
The detection flow of the sample detection device 20 of the present embodiment to the sample to be detected includes: moving the sample tube 215 on the sample rack 214 to the loading position through the transmission mechanism 211, and reading the identification information of the sample tube 215 through the scanning mechanism 216; the reagent card 221 is moved to the sample application position along the first direction x by the first reagent card loading mechanism 222, and the reagent card 221 is positioned directly below the sample tube 215. The sample tube 215 is squeezed by a dropping mechanism, so that the sample to be measured of the sample tube 215 is dropped on the sample adding hole of the reagent card 221; the reagent card 221 to which the sample to be measured has been applied is moved from the application position to the first transport belt 234 by the first reagent card loading mechanism 222, and the first transport belt 234 moves the reagent card 221 to the second reagent card loading mechanism 231, so that the second reagent card loading mechanism 231 turns over the reagent card 221 to be placed upright. The vertically positioned reagent card 221 is transferred by the first push-out mechanism 235 into the entrance position of the endless rotating belt 232 to be received in the receiving container 233. Pushing out the reagent card 221 located at the outlet position of the endless rotating belt 232 to the second driving belt 237 by the second pushing-out structure 236; pushing the reagent card 221 on the second belt 237 by the pushing mechanism 238 so that the second belt 237 moves the reagent card 221 to the collecting position; acquiring the result of the reagent card 221 by the acquisition unit 24 to obtain detection data; the collected reagent card 221 is moved to a trash by the second belt 237.
Referring to fig. 5, fig. 5 is a schematic structural diagram of a sample detection device according to a third embodiment of the present invention. The sample test device 30 of the present embodiment includes a sample tube storage unit 31, a reagent card storage unit 32, a reagent card reaction unit 33, and a collection unit 34. The reagent card stored in the reagent card storage unit 32 is arranged in a sheet shape.
The reagent card storage unit 32 includes a first reagent cassette 322, a first reagent card loading mechanism 323, and a reagent card transport mechanism, wherein the first reagent cassette 322 and the first reagent card loading mechanism 323 are disposed at one side of the reagent card transport mechanism. The first reagent cassette 322 stores reagent cards in a stacked manner, and the first reagent cassette 322 may be the reagent cassette 323 shown in fig. 4, which is not described herein again. The first reagent card loading mechanism 323 transfers the reagent card into the reagent card transport mechanism and is transported by the reagent card transport mechanism to the sample loading location. Where the first reagent card loading mechanism 323 may be a push-out mechanism, the reagent card transport mechanism may include, but is not limited to, a flat belt, a synchronous belt, or a chain belt.
As shown in fig. 5, the reagent card reaction unit 33 includes a second reagent cassette 331 and a second reagent card loading mechanism, the second reagent cassette 331 and the second reagent card loading mechanism are disposed at the other side of the reagent card transfer mechanism, the first reagent card loading mechanism 323 transfers the reagent card loaded with the sample to be tested into the second reagent cassette 331 via the reagent card transfer mechanism, and the second reagent cassette 331 stores the reagent cards in a stacked manner. Wherein the second reagent card loading mechanism is adapted to move the position of a reagent card located in the second reagent cassette 331.
Optionally, the second reagent cartridge 331 comprises a multi-layer storage chamber, and the second reagent card loading mechanism is used to move the position of the multi-layer storage chamber, e.g., the second reagent card loading mechanism moves the storage chamber up and down; each storage chamber is for storing a reagent card.
In the present embodiment, the first reagent card loading mechanism 323 transfers the reagent card with the sample to be tested into the second reagent cassette 331 via the reagent card transfer mechanism, and the second reagent cassette 331 stores the reagent card in a stacking manner, thereby reducing the volume occupied by the reagent card reaction unit 33, reducing the volume of the sample testing device 30, realizing miniaturization, and being suitable for various scenes.
The reagent card reaction unit 33 includes a first pushing mechanism 333 and a first reagent card loading mechanism 323 disposed on one side of the reagent card transport mechanism, and the first pushing mechanism 333 is used to push the reagent card loaded with the sample to be measured into the second reagent cartridge 331.
Alternatively, as shown in fig. 5, the sample tube storage unit 31 includes a transmission mechanism, a sample introduction mechanism 311 and an unloading mechanism 312, the sample introduction mechanism 311 includes a plurality of sample holders 313, the sample holders 313 are used for placing sample tubes, for example, one sample holder 313 can place 5 sample tubes or 10 sample tubes, so that the sample tube storage unit 31 stores a plurality of sample tubes. The transmission mechanism is used for moving the sample tube on the sample rack 313 to the sample application position, and after the sample tube injects the sample to be tested into the reagent card, the transmission mechanism moves the sample tube on the sample rack 313 to the unloading mechanism 312, so that the unloading mechanism 312 unloads the sample tube on the sample rack 313.
Optionally, the second reagent card loading mechanism further moves the reagent card to the collecting position, so that the collecting unit 34 is used for collecting the result of the reagent card to obtain the detection data; the sample testing device 30 moves the collected reagent card to a waste bin.
Optionally, the sample detection device 30 includes a negative pressure sterilization mechanism, and the negative pressure sterilization mechanism is configured to at least suck the gas at the sample application position, and uniformly collect and sterilize the gas, so as to prevent the sample detection device 30 from generating a risk of leakage of aerosol pollution, and improve the safety of the sample detection device 30.
Optionally, the sample detection device 30 includes an ultraviolet lamp disinfection mechanism, and the ultraviolet lamp disinfection mechanism is configured to disinfect the ultraviolet lamp after the sample detection device 30 detects the detected samples of all the detected persons.
Optionally, as shown in fig. 5, the sample tube storage unit 31 further includes a scanning mechanism 315 for scanning a barcode region of the sample tube to read the identification information of the sample tube. The sample detection device 30 obtains the position information of the sample tube on the sample frame 313, and binds the identification information with the position information of the sample tube on the sample frame 313; the sample detection device 30 also binds the position information of the sample tube on the sample rack 313 with the position information of the corresponding reagent card in the reagent storage unit 32, thereby binding the reagent card with the identification information.
Optionally, the sample detecting device 30 includes a dropping mechanism disposed at the sample adding position, and the dropping mechanism is configured to press the sample tube, so that the sample to be detected of the sample tube is dropped on the sample adding hole of the reagent card.
Alternatively, as shown in FIG. 5, the sample testing device 30 includes a base 36 having a rolling member, and the sample testing device 30 can be rolled by the rolling member to make the sample testing device 1 portable and mobile, thereby improving the convenience of use.
Optionally, the sample detection device 30 includes a temperature sensor for detecting the detection temperature of the sample detection device 30, so that the operation temperature condition of the sample detection device 30 can be known in real time, and the convenience and safety of use can be improved.
The reagent card of this embodiment passes through second reagent cassette 331 from the application of sample position to the collection position, and second reagent card loading mechanism is used for moving the position of the reagent card that is located in second reagent cassette 331, and therefore the distance that the reagent card moves from the application of sample position to the collection position is greater than the linear distance from the application of sample position to the collection position, reduces the volume that reagent card reaction unit 33 occupies, reduces the volume of sample detection device 30, realizes the miniaturization, is applicable to multiple scenes.
The detection flow of the sample detection device 30 of the present embodiment to the sample to be detected includes: the sample tube on the sample rack 313 is moved to the sample application position by the transmission mechanism, and the identification information of the sample tube is read by the scanning mechanism 315. Transferring the reagent card into the reagent card conveying mechanism through the first reagent card loading mechanism 323, and conveying the reagent card to the sample adding position through the reagent card conveying mechanism so as to enable the reagent card to be positioned below the sample tube; extruding the sample tube by a feeding mechanism so as to drip the measured sample of the sample tube on a sample adding hole of the reagent card; the sample tube on the sample rack 313 is moved to the unloading mechanism 312 by the driving mechanism, so that the unloading mechanism 312 unloads the sample tube on the sample rack 313. Pushing the reagent card to which the sample to be measured has been added into the second reagent cassette 331 by the first pushing-out mechanism 333; moving the reagent card to the collection position through the second reagent card loading mechanism, so that the collection unit 34 collects the result of the reagent card to obtain the detection data; and moving the collected reagent card to a garbage can.
Referring to fig. 6, fig. 6 is a schematic structural diagram of a sample detection device according to a fourth embodiment of the present application. The sample test device 40 of the present embodiment includes a sample tube storage unit 41, a reagent card storage unit 42, a reagent card reaction unit 43, and a collection unit 44. The reagent card 421 stored in the reagent card storage unit 42 is in a sheet shape.
The reagent card reaction unit 43 forms a bent transmission path, and the reagent card 421 to which the sample to be measured is applied is transmitted to the collection site along the bent transmission path. The shape of the bent transmission path may be circular, C-shaped, rectangular, or bow-shaped.
The reagent card reaction unit 43 includes a first transfer mechanism 431, a second transfer mechanism 432, and a first push-out mechanism 433, the first transfer mechanism 431 and the second transfer mechanism 432 are disposed side by side, and the first push-out mechanism 433 is disposed at the same end of the first transfer mechanism 431 and the second transfer mechanism 432, for moving the reagent card 421 on the first transfer mechanism 431 to the second transfer mechanism 432.
The reagent card reaction unit 43 of this embodiment forms a bent transmission path, and the reagent card 421 with the sample to be detected is transmitted to the collection position along the bent transmission path, so as to reduce the volume occupied by the reagent card reaction unit 43, reduce the volume of the sample detection device 40, realize miniaturization, and be suitable for various scenes.
Alternatively, as shown in fig. 6, the sample tube storage unit 41 includes a transmission mechanism 411, an injection mechanism 412 and an unloading mechanism 413, the injection mechanism 412 includes a plurality of sample holders 414, the sample holders 414 are used for placing sample tubes 415, for example, one sample holder 414 can place 5 sample tubes 415 or 10 sample tubes 415, so that the sample tube storage unit 41 stores a plurality of sample tubes 415. The driving mechanism is used to move the sample tube 415 on the sample rack 414 to the loading position, and after the sample tube 415 injects the sample to be tested into the reagent card 421, the driving mechanism moves the sample tube 415 on the sample rack 414 to the unloading mechanism 413, so that the unloading mechanism 413 unloads the sample tube 415 on the sample rack 414.
Alternatively, as shown in fig. 6, the reagent card storage unit 42 includes a second pushing mechanism 422, a reagent cassette 423, a third transport mechanism 424, and a third pushing mechanism 425, the second pushing mechanism 422 being used to move a reagent card 421 of the reagent cassette 423 to the third transport mechanism 424, and the third transport mechanism 424 moving the reagent cassette 423 to the sample application site. The reagent cassette 423 is the same as the second pushing mechanism 422 shown in fig. 4, and is not described herein again. The third pushing mechanism 425 is used to move the reagent card 421 to the first transport mechanism 431.
Optionally, the sample testing device 40 includes a dropping mechanism disposed at the sample loading position, and the dropping mechanism is configured to grab the sample tube 415 above the reagent card 421 and press the sample tube 415, so that the sample to be tested in the sample tube 415 is dropped on the sample loading hole of the reagent card 421.
The second transport mechanism 432 is configured to move the reagent card 421 to the collecting position, and the collecting unit 44 collects a result of the reagent card 421 to obtain detection data; the second transport mechanism 432 is used to move the collected reagent card 421 to a waste bin.
Optionally, the sample detection device 40 includes a negative pressure sterilization mechanism for sterilizing the sample application site to prevent the sample detection device 40 from having a risk of contamination and improve the safety of use of the sample detection device 40.
Optionally, the sample detection device 40 includes an ultraviolet lamp disinfection mechanism, and the ultraviolet lamp disinfection mechanism is configured to disinfect an ultraviolet lamp after the sample detection device 40 detects the detected samples of all the detected persons.
Optionally, as shown in fig. 6, the sample tube storage unit 41 further includes a scanning mechanism for scanning a barcode region of the sample tube 415 to read the identification information of the sample tube 415. The sample detection device 40 obtains the position information of the sample tube 415 on the sample rack 414, and binds the identification information with the position information of the sample tube 415 on the sample rack 414; the sample detection device 40 also binds the position information of the sample tube 415 on the sample rack 414 with the position information of the corresponding reagent card 421 on the reagent storage unit 42, thereby binding the reagent card 421 with the identification information.
Optionally, the sample testing device 40 includes a dropping mechanism disposed at the sample loading position, and the dropping mechanism is configured to press the sample tube 415, so that the sample to be tested in the sample tube 415 is dropped on the sample loading hole of the reagent card 421.
Optionally, the sample detection device 40 comprises a temperature sensor for detecting the detection temperature of the sample detection device 40.
Referring to fig. 7, fig. 7 is a schematic structural diagram of a fifth embodiment of the sample detection device of the present application. The sample test device 50 of the present embodiment includes a sample tube storage unit 51, a reagent card storage unit 52, a reagent card reaction unit 53, and a collection unit 54. The reagent card stored in the reagent card storage unit 52 is arranged in a sheet shape.
The sample tube storage unit 51 includes a sample tube storage mechanism 511, a sample tube transport mechanism 512, and a sample tube loading mechanism 513, wherein the sample tube storage mechanism 511 is used for storing a sample tube 514, and the sample tube transport mechanism 512 forms a transport path 516 between the sample tube storage mechanism 511 and the sample loading position. The sample tube loading mechanism 513 has a motion path 517, and the transport path 516 and the motion path 517 form a first intersection position a and a second intersection position B, wherein the sample tube loading mechanism 513 is configured to load the sample tube 514 stored by the sample tube storage mechanism 511 onto the sample tube transport mechanism 512 at the first intersection position a and unload the sample tube 514 from the sample tube transport mechanism 512 from the second intersection position B.
The sample tube transport mechanism 512 is used to move the sample tube 514 to the loading position. The reagent card storage unit 52 includes a reagent card transport mechanism for moving a reagent card to a loading position and a reagent cassette 522. The reagent cassette 522 is the same as the second pushing mechanism 422 shown in fig. 4, and is not repeated herein.
The reagent card reaction unit 53 and the collecting unit 54 of this embodiment may be the reagent card reaction unit and the collecting unit disclosed in any of the above embodiments, and are not described herein again.
Optionally, the sample tube loading mechanism 513 includes a rotating arm 518 and a grip 519, the grip 519 being disposed at one end of the rotating arm 518 and being used to load or unload the sample tube 514, the rotating arm 518 being rotated about a set center of rotation.
The sample detection device 50 of the present embodiment reduces the volume occupied by the reagent card reaction unit 53, reduces the volume of the sample detection device 50, realizes miniaturization, and is suitable for various scenes.
Referring to FIGS. 8-9, FIG. 8 is a schematic structural diagram of a sample testing device according to a sixth embodiment of the present invention; fig. 9 is a schematic diagram of the structure of the sample tube and the reagent card in fig. 8. The sample test device 60 of the present embodiment includes a sample tube storage unit 61, a reagent card storage unit 62, a reagent card reaction unit 63, and a collection unit. The reagent cards 621 stored in the reagent card storage unit 62 are arranged in a stripe shape.
The sample testing device 60 further includes a loading mechanism 65, the loading mechanism 65 is disposed at the loading position, the loading mechanism 65 loads the reagent card 621 into the sample tube 611, and the reagent card reaction unit 63 is further configured to store the sample tube 611 loaded with the reagent card 621.
The reagent card reaction unit 63 forms a bent transmission path, and the reagent card 621 to which the sample to be measured is applied is transmitted to the collection site along the bent transmission path, wherein the bent transmission path is circular. In other embodiments, the meandering conveyance path may be S-shaped, C-shaped, or rectangular in shape.
For example, the reagent card reaction unit 63 is a circular turntable 631, and the circular turntable 631 is provided with a plurality of positioning holes for positioning the sample tubes 611. The circular turntable 631 rotates in a period equal to the reaction time of the sample detection device 60.
The sample tube storage unit 61 includes a sample rack 612, a first transfer mechanism 613, a second transfer mechanism 614, and an unloading mechanism 615; the sample rack 612 is used for placing the sample tube 611, and the first transfer mechanism 613 is used for moving the sample tube 611 to the sample application position, so as to mount the sample tube 611 in the positioning hole. The second transfer mechanism 614 is used to move the tested sample tube 611 to the unloading mechanism 615, and the unloading mechanism 615 is used to unload the sample tube 611.
The detection flow of the sample detection device 60 of the present embodiment includes: the sample tube 611 is moved to the sample addition position by the first transfer mechanism 613, and the sample tube 611 is mounted in the positioning hole; the reagent card 621 is thrown into the sample tube 611 by the throwing mechanism 65; controlling the circular turntable 631 to rotate to the collecting position so that the collecting unit collects the result of the reagent card 621 to obtain the detection data; the inspected sample tube 611 is moved to the unloading mechanism 615 by the second transfer mechanism 614, and the unloading mechanism 615 is used to unload the sample tube 611.
The sample detection device 60 of the present embodiment reduces the volume occupied by the reagent card reaction unit 63, reduces the volume of the sample detection device 60, realizes miniaturization, and is suitable for various scenes.
As shown in fig. 9, the sample tube 611 is a V-shaped sample cup, the sample tube 611 stores lysis solution, and a reagent card opening is formed at the top of the sample tube 611, so that the reagent card 621 enters the sample tube 611 through the reagent card opening. The shape of the opening of the reagent card is the same as the cross-sectional shape of the reagent card 621, so that the reagent card 621 is prevented from shaking in the sample tube 611.
The bottom of the sample tube 611 is provided with a fool-proof mechanism 616 corresponding to the positioning hole, so that when the sample tube 611 is mounted in the positioning hole, the direction of the reagent card 621 is fixed, which is convenient for the collection unit to collect the result of the reagent card 621.
The bottom of the sample tube 611 and the fool-proof mechanism 616 form a positioning step so that the sample tube 611 is mounted to the positioning hole through the positioning step.
Optionally, the sample tube 611 is further provided with a partition plate between the sampling tool and the reagent card 621, so as to prevent the sampling tool from touching the reagent card 621, thereby improving the detection accuracy.
Referring to fig. 10, fig. 10 is a schematic diagram of a seventh embodiment of a sample testing device according to the present application. The sample testing device 70 of this embodiment is the sample testing device disclosed in the above embodiment, and the sample testing device 70 is respectively connected to the server 71 and the sample tube distribution device 72 in a communication manner.
The sample tube distributing device 72 obtains personal information of a measured person, automatically distributes the sample tubes for the measured person to add a measured sample to the sample tubes, automatically binds the personal information of the measured person with the distributed identification information of the sample tubes, and reports the bound personal information to the server 71. The sample detection device 70 reads the identification information of the sample tube and detects the detected sample in the sample tube to obtain detection data; and reports the identification information of the sample tube and the corresponding detection data to the server 71. The server binds the detection data with the personal information based on the identification information of the sample tube. Therefore, manual operation is not needed, the efficiency is improved, and the cost is reduced; the privacy of the tested person is protected, the personal information is prevented from being leaked, and the safety is improved.
Referring to fig. 11, fig. 11 is a schematic structural diagram of a first embodiment of the sample tube of the present application. The sample tube 80 of the present application is the sample tube disclosed in the above embodiment, and the sample tube 80 includes a tube body 81 and a self-sealing cover 82, and the self-sealing cover 82 is connected to the tube body 81. The connection method may be to plug the self-sealing cover 82 into the tube 81, and to achieve the mutual connection through the interference fit between the two. The tube 81 and/or the self-sealing cover 82 may also be provided with threads, and the tube 81 and the self-sealing cover 82 may be tightly connected by threaded connection.
Specifically, the tube 81 is elastically deformed after being pressed, and the self-sealing cover 82 is kept sealed in a natural state. Thus, the tube 81 is squeezed to increase the internal pressure, and the self-sealing cover 82 is opened by the air pressure after the tube 81 is squeezed, so that the sample to be measured of the sample tube 80 can be dropped. The self-sealing cover 82 may be an elastic plug, such as a rubber plug or a silicone plug.
In a possible embodiment, the sample tube 80 further comprises a stopper 83, and the stopper 83 is used for stopping a sampling tool placed in the tube body 81 from acting on the self-sealing cover 82, so as to prevent the self-sealing cover 82 from being opened and leaking liquid under the action of the gravity of the sampling tool.
Alternatively, the stopper 83 is a filter net disposed on the side of the opening of the self-sealing cover 82 facing the bottom of the tube 81. The filter screen may be integrally designed with the self-sealing cover 82, or may be separately provided.
Referring to fig. 12, fig. 12 is a schematic structural diagram of a second embodiment of the sample tube of the present application. The sample tube 90 of the present application is the sample tube disclosed in the above embodiment, the sample tube 90 includes a tube body 91 and a self-sealing cover 92, the self-sealing cover 92 is disposed at an opening of the tube body 91, the self-sealing cover 92 is kept sealed in a natural state, and can be opened after the tube body 91 is squeezed, so that a sample detection liquid formed after mixing with a sample to be detected in the sample tube 90 flows out and can be instilled.
As shown in fig. 12, the self-sealing cover 92 includes a body section 921, an elastic member 922 and a piston 923, wherein the body section 921 forms a passage for communicating with the tube 91; in a natural state, the piston 923 seals the channel under the elastic support of the elastic member 922, and when the acting force is applied to the tube 91, the liquid outlet end of the body section 921 abuts against the acting surface, so that the piston 923 overcomes the elastic support of the elastic member 922 to open the channel under the applied acting force. The elastic member 922 may be a spring.
Optionally, the main body part 921 includes a first cover 924, a second cover 925 and a support pillar 929, the first cover 924 forms a channel for communicating with the pipe 91, one end of the support pillar 929 is connected to the piston 923, the other end of the support pillar 929 is connected to the second cover 925, and the elastic member 922 is sleeved on the support pillar 929. When the liquid outlet end of the body 921 abuts against the action surface, the piston 923 overcomes the elastic support of the elastic member 922 to open the channel between the first cover 924 and the tube 91, thereby achieving the dripping. After the acting force is cancelled, the piston 923 can always keep the state of closing the channel under the acting force generated by the elastic piece 922, and the leakage of the liquid which is opened by the self-sealing cover body 92 under the action of the gravity of the sampling tool is avoided.
Referring to fig. 13, fig. 13 is a schematic structural diagram of a third embodiment of the sample tube of the present application. The sample tube 100 of the present application includes a tube body 101 and a self-sealing cover 102, and the self-sealing cover 102 may be the same as the self-sealing cover 82 or the self-sealing cover 92, and will not be described herein again. The bottom of body 101 is equipped with protection architecture 103 to avoid sample pipe 100 to be extruded the sample of being surveyed in the in-process of transport, avoid the sample of being surveyed of sample pipe 100 to leak. The bottom arc of the pipe body 101 applies pressure to press the pipe body 101.
Referring to fig. 14-15, fig. 14 is a schematic structural view of a fourth embodiment of the sample tube of the present application; fig. 15 is a schematic cross-sectional view of the sample tube of fig. 14. The sample tube 130 of the present application is the sample tube disclosed in the above embodiment, and the sample tube 130 includes a tube body 131 and a self-sealing cover 132, and the self-sealing cover 132 is connected to the tube body 131. The connection mode may be that the self-sealing cover 132 is plugged into the tube 131, and the self-sealing cover and the tube are connected by interference fit. Alternatively, the tube 131 and/or the self-sealing cover 132 may be provided with threads, and may be screwed to the tube 131.
The self-sealing cover 132 is kept closed in a natural state and can be opened after the tube 131 is squeezed, so that the sample to be measured of the sample tube 130 can be dripped. The self-sealing cover 132 may be an elastic plug, such as a rubber plug or a silicone plug.
The sample tube 130 further comprises a stopper 133, and the stopper 133 is used for stopping a sampling tool put into the tube body 131 from acting on the self-sealing cover 132, so as to prevent the self-sealing cover 132 from being opened and leaking liquid under the action of gravity of the sampling tool.
Optionally, the stopper 133 is a rib disposed around the opening of the self-sealing cover 132 and extending toward the bottom of the tube 131 to prevent the sampling tool of the sample tube 130 from falling into the opening of the self-sealing cover 132 and avoid plugging the hole.
Referring now to fig. 16-17, fig. 16 is a schematic structural view of a fifth embodiment of the sample tube of the present application; fig. 17 is a schematic cross-sectional view of the sample tube of fig. 16. The sample tube 140 of the present application is the sample tube disclosed in the above embodiments, and the sample tube 140 includes a tube body 141 and a self-sealing cover 142. The self-sealing cover 142 is plugged into the tube 141, or the self-sealing cover 142 is provided with threads and screwed to the tube 141.
The self-sealing cover 142 is kept closed in a natural state and can be opened after the tube body 141 is squeezed, so that the sample to be measured of the sample tube 140 can be dropped.
The self-sealing cover 142 is an elastic body, such as an elastic plug, the self-sealing cover 142 is provided with a self-sealing cut, and the shape of the self-sealing cut can be a straight line shape or a cross shape, so as to avoid hole blocking.
In one possible embodiment, the sample detection device further comprises an information acquisition unit and a processing unit. The information acquisition unit is used for acquiring the personal information of the tested person, the processing unit is used for recording the position information of the sample tube storing the tested sample and placed in the sample tube storage unit, and the processing unit is also used for recording the binding information after the personal information is associated with the position information. Set up like this, make this sample detection device realize gathering the personal information who is surveyed the person, then the position that the distribution sample pipe was placed or the position that the monitoring sample pipe was placed to bind the personal information who is surveyed the person and the position of placing of being surveyed the sample, make final testing result can realize the one-to-one with being surveyed the person, the confusion does not appear, automated inspection reliability is high. The above description is only for the purpose of illustrating embodiments of the present application and is not intended to limit the scope of the present application, and all modifications of equivalent structures and equivalent processes, which are made by the contents of the specification and the drawings of the present application or are directly or indirectly applied to other related technical fields, are also included in the scope of the present application.

Claims (18)

1. A sample testing device, comprising:
the sample tube storage unit is used for storing a sample tube and moving the sample tube to a sample adding position, and the sample tube stores a detected sample;
the reagent card storage unit is used for storing a plurality of reagent cards and moving the reagent cards to the sample adding position so that the tested samples of the sample tubes can be contacted with the reagent cards;
the reagent card reaction unit is used for storing the reagent card added with the tested sample and moving the reagent card added with the tested sample from the sample adding position to the collecting position, wherein the moving distance of the reagent card from the sample adding position to the collecting position is larger than the linear distance from the sample adding position to the collecting position;
and the acquisition unit is used for acquiring the result of the reagent card to obtain detection data.
2. The sample testing device according to claim 1, wherein said reagent cards are arranged in a sheet form, and the reagent cards to which said sample to be tested have been added are stacked on each other in the thickness direction of said reagent cards in said reagent card reaction unit.
3. The apparatus according to claim 2, wherein the reagent card reaction unit includes an endless rotating belt and a plurality of receptacles spaced apart from each other in a circumferential direction of the endless rotating belt, and after the reagent card is placed in one of the receptacles, a thickness direction of the reagent card is directed to another receptacle adjacent thereto.
4. The sample testing device according to claim 3, wherein said reagent card storage unit comprises a first reagent card loading mechanism for loading the reagent card stored in said reagent card storage unit into said loading position along a first direction, and an axial direction of said endless rotary belt is arranged along said first direction.
5. The sample testing device of claim 4, wherein when said first reagent card loading mechanism drives said reagent card, the thickness direction of said reagent card is disposed in a second direction perpendicular to said first direction, and said reagent card reaction unit comprises a second reagent card loading mechanism that inverts said reagent card such that the thickness direction of said reagent card is disposed in a third direction perpendicular to said first and second directions and transfers said reagent card into said receptacle in said first direction.
6. The sample testing device of claim 5, wherein said first and third directions are horizontal and said second direction is vertical.
7. The sample testing device of claim 1, wherein said reagent card storage unit comprises a first reagent cartridge, a first reagent card loading mechanism, and a reagent card transport mechanism, said first reagent cartridge and first reagent card loading mechanism being disposed on one side of said reagent card transport mechanism, said first reagent cartridge storing said reagent cards in a stacked manner, said first reagent card loading mechanism transferring said reagent cards into said reagent card transport mechanism and being transported by said reagent card transport mechanism to said loading location;
the reagent card reaction unit comprises a second reagent card box and a second reagent card loading mechanism, the second reagent card box and the second reagent card loading mechanism are arranged on the other side of the reagent card conveying mechanism, the first reagent card loading mechanism conveys a reagent card added with the tested sample into the second reagent card box through the reagent card conveying mechanism, and the second reagent card box stores the reagent card in a stacking mode.
8. The apparatus according to claim 1, wherein the reagent card reaction unit forms a bent transport path, and the reagent card to which the sample to be measured is applied is transported to the collection site along the bent transport path.
9. The apparatus according to claim 1, further comprising a releasing mechanism disposed at the sample loading position, wherein the releasing mechanism is configured to press the sample tube so that the sample to be tested is dropped on the reagent card.
10. The sample testing device of claim 1, further comprising a dispensing mechanism disposed at the sample application site, wherein the dispensing mechanism dispenses the reagent card into the sample tube, and wherein the reagent card reaction unit is further configured to store the sample tube into which the reagent card has been dispensed.
11. The sample testing device of claim 1, wherein said sample tube storage unit comprises a sample tube storage mechanism for storing said sample tube, a sample tube transport mechanism forming a transport path between said sample tube storage mechanism and said loading position, and a sample tube loading mechanism having a motion path forming a first intersection location and a second intersection location with said motion path, wherein said sample tube loading mechanism is configured to load said sample tube stored by said sample tube storage mechanism onto said sample tube transport mechanism at said first intersection location and to unload said sample tube from said sample tube transport mechanism from said second intersection location.
12. The sample testing device of claim 11, wherein said sample tube loading mechanism comprises a rotatable arm and a grip, said grip being disposed at one end of said rotatable arm and being configured to load or unload said sample tube, said rotatable arm being rotatable about a set center of rotation.
13. The sample testing device of claim 1, further comprising a negative pressure sterilization mechanism for negative pressure sterilization of the sample application site.
14. The sample testing device of claim 1, wherein the sample tube comprises a tube body and a self-sealing cover that remains sealed in a natural state and can be opened after the tube body is squeezed.
15. The sample testing device of claim 14, wherein the sample tube further comprises a stop member for stopping a sampling tool placed in the tube from acting on the self-sealing cover under the force of gravity.
16. The apparatus according to claim 15, wherein the stopper is a filter disposed at a side of the opening of the self-sealing cover facing the bottom of the tube;
or the stop piece is a convex rib which is arranged around the opening of the self-sealing cover body and extends towards the bottom of the tube body.
17. The sample testing device according to claim 14, wherein said self-sealing cover is an elastic body and is provided with a self-sealing cut;
or, the self-sealing cover body comprises a main body part, an elastic part and a piston, wherein the main body part forms a channel for communicating with the tube body, the piston seals the channel under the elastic support of the elastic part in a natural state, and when the internal pressure of the tube body is increased, the piston overcomes the elastic support of the elastic part to open the channel.
18. The sample testing device of any one of claims 1 to 17, further comprising:
the information acquisition unit is used for acquiring personal information of the testee;
the processing unit is used for recording the position information of the sample tube storing the tested sample, which is placed in the sample tube storing unit;
the processing unit is further used for recording binding information after the personal information is associated with the position information.
CN202210352054.9A 2022-04-02 2022-04-02 Sample detection device Pending CN114859030A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202210352054.9A CN114859030A (en) 2022-04-02 2022-04-02 Sample detection device

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202210352054.9A CN114859030A (en) 2022-04-02 2022-04-02 Sample detection device

Publications (1)

Publication Number Publication Date
CN114859030A true CN114859030A (en) 2022-08-05

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN202210352054.9A Pending CN114859030A (en) 2022-04-02 2022-04-02 Sample detection device

Country Status (1)

Country Link
CN (1) CN114859030A (en)

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