CN114854189A - High-permeability polyurethane transparent film and preparation method and application thereof - Google Patents
High-permeability polyurethane transparent film and preparation method and application thereof Download PDFInfo
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- CN114854189A CN114854189A CN202210637170.5A CN202210637170A CN114854189A CN 114854189 A CN114854189 A CN 114854189A CN 202210637170 A CN202210637170 A CN 202210637170A CN 114854189 A CN114854189 A CN 114854189A
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- 229920002635 polyurethane Polymers 0.000 title claims abstract description 171
- 239000004814 polyurethane Substances 0.000 title claims abstract description 171
- 238000002360 preparation method Methods 0.000 title claims abstract description 27
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims abstract description 81
- 239000012046 mixed solvent Substances 0.000 claims abstract description 43
- 239000002245 particle Substances 0.000 claims abstract description 40
- 238000001035 drying Methods 0.000 claims abstract description 29
- 238000006243 chemical reaction Methods 0.000 claims abstract description 26
- 239000000126 substance Substances 0.000 claims abstract description 26
- 238000002156 mixing Methods 0.000 claims abstract description 22
- 125000005233 alkylalcohol group Chemical group 0.000 claims abstract description 17
- 238000000034 method Methods 0.000 claims abstract description 16
- 229920006264 polyurethane film Polymers 0.000 claims description 19
- 229940068918 polyethylene glycol 400 Drugs 0.000 claims description 12
- 239000002202 Polyethylene glycol Substances 0.000 claims description 9
- 229920001223 polyethylene glycol Polymers 0.000 claims description 9
- MKRNVBXERAPZOP-UHFFFAOYSA-N Starch acetate Chemical compound O1C(CO)C(OC)C(O)C(O)C1OCC1C(OC2C(C(O)C(OC)C(CO)O2)OC(C)=O)C(O)C(O)C(OC2C(OC(C)C(O)C2O)CO)O1 MKRNVBXERAPZOP-UHFFFAOYSA-N 0.000 claims description 7
- 229940113115 polyethylene glycol 200 Drugs 0.000 claims description 4
- 229940057847 polyethylene glycol 600 Drugs 0.000 claims description 4
- 125000006527 (C1-C5) alkyl group Chemical group 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 230000035699 permeability Effects 0.000 abstract description 32
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 17
- 230000008569 process Effects 0.000 abstract description 12
- 230000000694 effects Effects 0.000 abstract description 10
- 210000000416 exudates and transudate Anatomy 0.000 abstract description 7
- 239000001257 hydrogen Substances 0.000 abstract description 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract description 6
- 238000001179 sorption measurement Methods 0.000 abstract description 5
- 239000000463 material Substances 0.000 abstract description 4
- 239000011148 porous material Substances 0.000 abstract description 4
- 230000002195 synergetic effect Effects 0.000 abstract description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 28
- 206010052428 Wound Diseases 0.000 description 16
- 208000027418 Wounds and injury Diseases 0.000 description 16
- 238000003756 stirring Methods 0.000 description 16
- 238000010998 test method Methods 0.000 description 8
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- 238000007605 air drying Methods 0.000 description 7
- 230000000052 comparative effect Effects 0.000 description 5
- 230000001276 controlling effect Effects 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 230000029663 wound healing Effects 0.000 description 5
- 230000005540 biological transmission Effects 0.000 description 4
- 238000010586 diagram Methods 0.000 description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
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- 229910052710 silicon Inorganic materials 0.000 description 3
- 239000010703 silicon Substances 0.000 description 3
- 238000009825 accumulation Methods 0.000 description 2
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- 230000015572 biosynthetic process Effects 0.000 description 2
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- 241000894006 Bacteria Species 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
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- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
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- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J5/00—Manufacture of articles or shaped materials containing macromolecular substances
- C08J5/18—Manufacture of films or sheets
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2375/00—Characterised by the use of polyureas or polyurethanes; Derivatives of such polymers
- C08J2375/04—Polyurethanes
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2403/00—Characterised by the use of starch, amylose or amylopectin or of their derivatives or degradation products
- C08J2403/04—Starch derivatives
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- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2471/00—Characterised by the use of polyethers obtained by reactions forming an ether link in the main chain; Derivatives of such polymers
- C08J2471/02—Polyalkylene oxides
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- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K5/00—Use of organic ingredients
- C08K5/04—Oxygen-containing compounds
- C08K5/06—Ethers; Acetals; Ketals; Ortho-esters
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- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02W—CLIMATE CHANGE MITIGATION TECHNOLOGIES RELATED TO WASTEWATER TREATMENT OR WASTE MANAGEMENT
- Y02W90/00—Enabling technologies or technologies with a potential or indirect contribution to greenhouse gas [GHG] emissions mitigation
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Abstract
The invention provides a high-permeability polyurethane transparent film and a preparation method and application thereof, belonging to the technical field of biomedical materials. Firstly, mixing polyurethane particles with a mixed solvent, and dissolving polyurethane by using dimethylformamide in the mixed solvent; then mixing with hydrophilic substances, and carrying out chemical reaction to enable the polyurethane to contain hydrophilic groups; finally, drying is carried out, and as the alkyl alcohol in the mixed solvent is incompatible with the polyurethane, pores are separated out and formed during drying, so as to achieve the purpose of moisture permeability; when the high-permeability polyurethane transparent film is used, a hydrophilic group (-OH) in polyurethane and water molecules contained in wound exudate form a hydrogen bond effect, moisture permeability is realized by utilizing adsorption-diffusion-adsorption of the water molecules, the permeability of the polyurethane transparent film is obviously improved by adopting the synergistic effect of micropore moisture permeability and hydrophilic moisture permeability, and the process flow is simplified.
Description
Technical Field
The invention belongs to the technical field of biomedical materials, and particularly relates to a high-permeability polyurethane transparent film, and a preparation method and application thereof.
Background
Researches of british scholars Winter and the like in the last 60 th century show that the wound is kept at a certain humidity, the wound healing is facilitated, the healing quality is improved, and particularly for the protection of a puncture part and the wound care, the wound needs to be covered and protected by a dressing in time. The dressing has the functions of creating a proper wound healing environment, a moist environment and proper oxygen permeability around the wound to ensure the smooth regeneration of epithelial cells, promote cell growth and tissue reconstruction, block external bacteria and prevent wound pollution.
The traditional dressings such as cotton pads, gauzes and the like have a certain wound protection effect due to wide raw material sources, soft texture and strong absorbability, and are a kind of dressings which are clinically used at present. But the limitation is also very obvious, if the dressing has no moisturizing effect, exogenous infection is easily caused when the dressing is permeated, granulation tissues are easily grown into gauze meshes to cause adhesion and scabbing, and the like, so that secondary damage is caused. Research into synthetic dressings has therefore become increasingly important. The polyurethane used as the material of the skin substitute has the advantages of easily available raw materials, simple storage, low cost, good biocompatibility and the like, so that the polyurethane has wide application in the biomedical field. At present, the production and application of medical polyurethane waterproof transparent dressing are reported. The dressing is ultrathin, highly elastic, transparent, waterproof, antibacterial, non-adhesive to wound, low in sensitization and moderate in viscosity. However, as the dressing, the dressing not only needs to have non-toxic antibacterial property, adhesiveness and the like, but also has the key of moisture permeability, so that an environment which is favorable for wound healing can be provided, and the permanent skin guarantee can be waited for the wound epithelization or the transition to the reconstruction. If the dressing has poor moisture permeability, it is easy to cause the accumulation of exudates and induce infection.
The water vapor transmission rate of normal human skin is 240-1800 g/m 2 24h, the higher the moisture permeability of the polyurethane dressing, the less likely it is to cause moisture accumulation, which is important for wound care and comfort of use for the patient. Polyurethane coating on marketThe raw materials are many, such as domestic representative products of Yongning sterile medical polyurethane films, Jiaxing Meisen sterile transparent dressings, Dingding sterile dressings and the like. Although the dressing has a certain waterproof and moisture permeable function, the moisture permeable effect of the dressing does not meet the requirement of an ideal dressing, and the dressing is adhered to the body surface to cause the skin surface to be whitish, so that patients feel uncomfortable. The representative foreign polyurethane dressing products such as Shushi 3000 self-adhesive film dressing and Shilehui IV3000 transparent dressing have high moisture permeability, but the dressing achieves the purpose of improving the moisture permeability by introducing hydrophilic groups through regulating the proportion of hard chain segments and soft chain segments in the synthesis process of polyurethane, and has the disadvantages of complex process, poor controllability and low implementation feasibility for factories. Therefore, how to simplify the process flow on the premise of ensuring the high permeability of the polyurethane transparent film is a difficult problem to be solved in the field.
Disclosure of Invention
The invention aims to provide a high-permeability polyurethane transparent film and a preparation method and application thereof. The preparation method provided by the invention is simple in process, and the prepared polyurethane transparent film has high permeability.
In order to achieve the above object, the present invention provides the following technical solutions:
the invention provides a preparation method of a high-permeability polyurethane transparent film, which comprises the following steps:
(1) mixing polyurethane particles with a mixed solvent to obtain a polyurethane solution; the mixed solvent comprises dimethylformamide and alkyl alcohol;
(2) mixing the polyurethane solution obtained in the step (1) with a hydrophilic substance, and carrying out a chemical reaction to obtain a modified polyurethane solution; the hydrophilic substance is at least one of polyethylene glycol and starch acetate;
(3) and (3) drying the modified polyurethane solution obtained in the step (2) to obtain the high-permeability polyurethane transparent film.
Preferably, the alkyl alcohol in the step (1) comprises at least one of C1-C5 alkyl alcohols.
Preferably, the mass ratio of the dimethylformamide to the alkyl alcohol in the step (1) is 1: (0.25 to 1).
Preferably, the mixing temperature in the step (1) is 60-85 ℃, and the mixing time is 1-6 h.
Preferably, the polyethylene glycol in the step (2) includes at least one of polyethylene glycol 200, polyethylene glycol 400 and polyethylene glycol 600.
Preferably, the mass ratio of the polyurethane particles, the mixed solvent and the hydrophilic substances in the step (1) to the hydrophilic substances in the step (2) is (0.05-0.4): 1: (0.005-0.16).
Preferably, the temperature of the chemical reaction in the step (2) is 60-85 ℃, and the time of the chemical reaction is 0.5-4 h.
Preferably, the drying temperature in the step (3) is 60-90 ℃, and the drying time is 8-12 h.
The invention also provides the high-permeability polyurethane transparent film prepared by the preparation method of the technical scheme.
The invention also provides the application of the high-permeability polyurethane transparent film in the technical scheme in medical dressings.
The invention provides a preparation method of a high-permeability polyurethane transparent film, which comprises the following steps: mixing polyurethane particles with a mixed solvent to obtain a polyurethane solution; the mixed solvent comprises dimethylformamide and alkyl alcohol; mixing the polyurethane solution with a hydrophilic substance, and carrying out a chemical reaction to obtain a modified polyurethane solution; the hydrophilic substance is at least one of polyethylene glycol and starch acetate; and drying the modified polyurethane solution to obtain the high-permeability polyurethane transparent film. Firstly, mixing polyurethane particles with a mixed solvent, and dissolving polyurethane by using dimethylformamide in the mixed solvent; then mixing with hydrophilic substances, and carrying out chemical reaction to enable the polyurethane to contain hydrophilic groups; finally, drying is carried out, and as the alkyl alcohol in the mixed solvent is incompatible with the polyurethane, pores are separated out and formed during drying, so as to achieve the purpose of moisture permeability; when the high-permeability polyurethane transparent film is used, the hydrophilic groups (-OH) in the polyurethane and water molecules contained in wound exudate form hydrogen bond action, and the adsorption-diffusion-adsorption of the water molecules are utilizedThe moisture permeability is improved obviously by adopting the synergistic effect of microporous moisture permeability and hydrophilic moisture permeability, and the process flow is simplified. Experimental results show that the MVTR average value of the transparent polyurethane film prepared by the preparation method is 2432-3003 g/m 2 /24h。
Drawings
FIG. 1 is a schematic side view of a highly transparent polyurethane film provided by the present invention;
FIG. 2 is a schematic structural view of a medical dressing provided by the present invention;
FIG. 3 is a process flow chart of the transparent polyurethane film with high transparency prepared in example 1;
FIG. 4 is a schematic diagram of the transparent polyurethane film prepared in example 1.
Detailed Description
The invention provides a preparation method of a high-permeability polyurethane transparent film, which comprises the following steps:
(1) mixing polyurethane particles with a mixed solvent to obtain a polyurethane solution; the mixed solvent comprises dimethylformamide and alkyl alcohol;
(2) mixing the polyurethane solution obtained in the step (1) with a hydrophilic substance, and carrying out a chemical reaction to obtain a modified polyurethane solution; the hydrophilic substance is at least one of polyethylene glycol and starch acetate;
(3) and (3) drying the modified polyurethane solution obtained in the step (2) to obtain the high-permeability polyurethane transparent film.
According to the invention, polyurethane particles are mixed with a mixed solvent to obtain a polyurethane solution.
In the present invention, the hardness of the polyurethane particles is preferably 75 to 90A. The source of the polyurethane particles is not particularly limited in the present invention, and commercially available products for film formation known to those skilled in the art may be used.
In the present invention, the mixed solvent includes dimethylformamide and an alkyl alcohol; the alkyl alcohol preferably comprises at least one of a C1-C5 alkyl alcohol, more preferably at least one of methanol, ethanol, and propanol. The sources of the dimethylformamide and the alkyl alcohol are not particularly limited in the present invention, and commercially available products known to those skilled in the art may be used. In the present invention, the dimethylformamide is used to dissolve polyurethane particles; because the alkyl alcohol is incompatible with the polyurethane particles, the polyurethane can be separated out to form pores during drying, thereby achieving the purpose of moisture permeation.
In the present invention, the mass ratio of dimethylformamide to alkyl alcohol is preferably 1: (0.25 to 1), more preferably 1: (0.5 to 1). The moisture permeability effect of the polyurethane transparent film can be further improved by controlling the mass ratio of the dimethylformamide to the alkyl alcohol. In the invention, the volatilization speed of the mixed solvent can be controlled by adjusting the proportion of the two solvents in the range, so that the polyurethane transparent film with different microstructures and porosities is obtained, and the moisture permeation effect of the polyurethane transparent film is further improved.
The method for preparing the mixed solvent is not particularly limited in the present invention, and the mixed solvent may be prepared by a method known to those skilled in the art.
In the invention, the mass ratio of the polyurethane particles to the mixed solvent is preferably (0.05-0.4): 1, more preferably (0.1 to 0.3): 1, more preferably 0.2: 1. the invention can control the volatilization speed of the polyurethane solution during drying by controlling the mass ratio of the polyurethane particles to the mixed solvent, thereby further improving the moisture permeability effect of the polyurethane transparent film.
In the invention, the mixing temperature of the polyurethane particles and the mixed solvent is preferably 60-85 ℃, more preferably 70-80 ℃, and more preferably 75 ℃; the mixing time is preferably 1-6 h, more preferably 2-4 h, and even more preferably 2.5 h. In the present invention, the mixing of the polyurethane particles with the mixed solvent is preferably performed under stirring conditions. The stirring rate is not particularly limited in the present invention, and may be a rate that is conventional to those skilled in the art.
After the polyurethane solution is obtained, the polyurethane solution is mixed with hydrophilic substances to carry out chemical reaction, so as to obtain the modified polyurethane solution. The invention mixes the polyurethane solution with hydrophilic substances to carry out chemical reaction, so that the polyurethane contains hydrophilic groups, when the high-permeability polyurethane transparent film is used, the hydrophilic groups (-OH) in the polyurethane and water molecules contained in wound exudate form hydrogen bond action, and the moisture permeability is realized by utilizing the adsorption-diffusion-adsorption of the water molecules.
In the present invention, the hydrophilic substance is at least one of polyethylene glycol and starch acetate; the polyethylene glycol preferably comprises at least one of polyethylene glycol 200, polyethylene glycol 400 and polyethylene glycol 600; when the hydrophilic substances are two, the mass ratio of the two hydrophilic substances is preferably 1: (0.1 to 1). The source of the hydrophilic substance in the present invention is not particularly limited, and commercially available products known to those skilled in the art may be used. In the invention, the hydrophilic substance is used for providing a hydrophilic group (-OH), which can form a hydrogen bond effect with water molecules contained in wound exudate, and moisture permeability is realized by utilizing adsorption-diffusion-adsorption of the water molecules, wherein-OH in polyethylene glycol and/or starch acetate and free-NCO groups in polyurethane undergo a chemical reaction, a polyurethane soft segment structure is partially changed, the flexibility of the polyurethane is increased, molecular chains are easier to turn over, the hydrophilic group is combined with the water molecules in the wound exudate to form a weak hydrogen bond, the steric hindrance is reduced, and the hydrophilicity is enhanced.
In the present invention, the mass ratio of the polyurethane particles, the mixed solvent, and the hydrophilic substance is preferably (0.05 to 0.4): 1: (0.005-0.16), more preferably (0.1-0.3): 1: (0.01 to 0.12), more preferably 0.2: 1: (0.015 to 0.09), most preferably 0.2: 1: (0.02-0.06). According to the invention, the number of hydrophilic groups in polyurethane can be controlled by controlling the mass ratio of the polyurethane particles, the mixed solvent and the hydrophilic substance, so that the moisture permeability effect of the polyurethane transparent film is further improved.
In the present invention, the mixing of the polyurethane solution and the hydrophilic substance is preferably performed under stirring conditions. The stirring rate is not particularly limited in the present invention, and may be a rate that is conventional to those skilled in the art.
In the invention, the temperature of the chemical reaction is preferably 60-85 ℃, more preferably 70-80 ℃, and more preferably 75 ℃; the time of the chemical reaction is preferably 0.5-4 h, more preferably 2-3 h, and even more preferably 2.5 h. The invention can improve the degree of chemical reaction by controlling the temperature and time of the chemical reaction, thereby improving the number of hydrophilic groups in the polyurethane.
After the chemical reaction is finished, the invention preferably carries out defoaming on the product obtained by the chemical reaction to obtain the modified polyurethane solution. In the present invention, the temperature of the de-bubbling is preferably room temperature; the time for removing bubbles is preferably 6-12 h, and more preferably 8-10 h; the de-bubbling is preferably performed in a vacuum drying oven. The type of the vacuum drying oven is not particularly limited in the invention, and instruments and equipment well known to those skilled in the art can be adopted. The invention can remove the bubbles in the polyurethane solution through the bubble removal, and prevent the bubbles in the product from influencing the appearance and the performance of the product.
After the modified polyurethane solution is obtained, the invention dries the modified polyurethane solution to obtain the high-permeability polyurethane transparent film.
In the present invention, the drying is preferably carried out in a forced air drying oven; the drying temperature is preferably 60-90 ℃, and more preferably 70-80 ℃; the drying time is preferably 8-12 hours, and more preferably 9-10 hours. The type of the air-blowing drying box is not particularly limited by the invention, and the air-blowing drying box can be made of instruments and equipment well known to those skilled in the art. The invention adopts drying to remove the moisture in the modified polyurethane solution and realize film forming, thereby obtaining the polyurethane transparent film.
Firstly, mixing polyurethane particles with a mixed solvent, and dissolving polyurethane by using dimethylformamide in the mixed solvent; then mixing with hydrophilic substances, and carrying out chemical reaction to enable the polyurethane to contain hydrophilic groups; finally, drying is carried out, and as the alkyl alcohol in the mixed solvent is incompatible with the polyurethane, pores are separated out and formed during drying, so as to achieve the purpose of moisture permeability; when the high-permeability polyurethane transparent film is used, a hydrophilic group (-OH) in polyurethane and water molecules contained in wound exudate form a hydrogen bond effect, moisture permeability is realized by utilizing adsorption-diffusion-adsorption of the water molecules, the permeability of the polyurethane transparent film is obviously improved by adopting the synergistic effect of micropore moisture permeability and hydrophilic moisture permeability, and the process flow is simplified.
The preparation method provided by the invention has simple process, can be used for preparing the thin and transparent high-permeability polyurethane transparent film in a large scale, has universality and is suitable for polyurethane particles for film forming in the market; the excellent water vapor transmission rate of the polyurethane film is realized based on the synergistic effect of the microporous moisture permeability and the hydrophilic group moisture permeability, and a comfortable microenvironment is provided for wound healing, so that the wound healing is accelerated, and good news is brought to the wound protection and nursing; the mixed solvent has different boiling points and different content ratios, and the polyurethane transparent films with different microstructures and porosities can be obtained by controlling the volatilization speed of the solvent.
The invention also provides the high-permeability polyurethane transparent film prepared by the preparation method of the technical scheme. The polyurethane transparent film provided by the invention has high permeability and the thickness of the polyurethane transparent film is 0.005-0.03 mm.
The side view of the transparent polyurethane film with high permeability provided by the invention is schematically shown in figure 1.
The invention also provides the application of the high-permeability polyurethane transparent film in the technical scheme in medical dressings.
The operation of applying the high-permeability polyurethane transparent film in the medical dressing is not particularly limited, and the application operation known by the technical personnel in the field can be adopted.
The structure schematic diagram of the medical dressing provided by the invention is shown in figure 2. As can be seen from fig. 2, the medical dressing is composed of a silicon paper protective leaf, a window-shaped frame, a polyurethane transparent film, a precut and a recording edge strip, and is convenient for one-hand operation; a pre-cut is designed below the window body frame, so that an operator can safely and accurately fix the pipeline; the fillet design makes the pasting more firm; the window-shaped frame and the silicon paper protecting leaves are designed in a staggered manner, so that the silicon paper protecting leaves can be removed and protected more conveniently; the strip design of the recording strip is convenient for recording the recording time and the illness state.
The technical solution of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. It is to be understood that the described embodiments are merely exemplary of the invention, and not restrictive of the full scope of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
A preparation method of a high-permeability polyurethane transparent film comprises the following steps:
(1) adding 2.5g of polyurethane particles with the hardness of 85A into 50g of mixed solvent of dimethylformamide and ethanol at the temperature of 80 ℃, and stirring for 2 hours to fully dissolve the polyurethane particles to obtain a polyurethane solution; wherein the mass ratio of the dimethylformamide to the ethanol is 1: 0.25;
(2) adding 0.75g of polyethylene glycol 400 into the polyurethane solution obtained in the step (1), stirring for 2 hours for chemical reaction, and then placing the mixture into a vacuum drying oven for normal-temperature defoaming for 8 hours to obtain a modified polyurethane solution; wherein the mass ratio of the polyurethane particles, the mixed solvent and the polyethylene glycol 400 is 0.05: 1: 0.015;
(3) and (3) drying the modified polyurethane solution obtained in the step (2) in a forced air drying oven at 60 ℃ for 12h to obtain the high-permeability polyurethane transparent film.
Example 1 a process flow diagram for preparing a highly transparent polyurethane film is shown in fig. 3. As can be seen from figure 3, the invention firstly adopts dimethylformamide and ethanol to mix with polyurethane particles, then adds hydrophilic substances to obtain a modified polyurethane solution, and then carries out defoaming and drying in sequence to obtain the high-permeability polyurethane transparent film.
FIG. 4 shows a schematic diagram of the transparent polyurethane film prepared in example 1. As can be seen from FIG. 4, the transparent polyurethane film with high transparency prepared in example 1 is thin and transparent, and has a thickness of 0.01 mm.
Comparative example 1
Commercially available conformable 3000 self-adhesive films
According to YY/T0471.2-2004, part 2 of the contact wound dressing test method: 3.2 test in breathable film dressing Water vapor Transmission Rate test the performance of the transparent polyurethane films prepared in example 1 and comparative example 1 was tested, and the test method was as follows:
samples of the test material were cut using the clamped flange (35.7. + -. 0.1mm in internal diameter) as a template. Sufficient water was added at room temperature (20 ℃ minimum) to provide an air gap (5. + -.1 mm) between the surface and the sample after placement. The circular sample is precisely capped on the flange of the test vessel. The sample was clamped without deforming it and a water tight seal was formed between the clamping plate and the cover plate. The mass W1 of the container, sample and liquid was weighed and recorded. The container was placed in a forced air oven with the sample facing upwards and the temperature maintained at (37. + -. 1 ℃ C.), 18 to 24h later, the container was removed from the oven and the test time T was recorded while immediately re-weighing the container, sample and liquid and recording the mass W2. The calculation formula of the water vapor transmission rate (MVTR) is as follows:
MVTR＝(W1-W2)×1000×24/T
the films of example 1 and comparative example 1 were tested in parallel 3 times according to the test method described above, and the transparent polyurethane film prepared in example 1 had an average MVTR value of 2454g/m 2 24h, the film of comparative example 1 had an average MVTR of 2482g/m 2 The result shows that the preparation method provided by the invention has simple process, can achieve the effect similar to 3000 commercially available comfortable skin, and is higher than the MVTR of normal human skin: 240 to 1800g/m 2 /24h。
Example 2
A preparation method of a high-permeability polyurethane transparent film comprises the following steps:
(1) adding 5g of polyurethane particles with the hardness of 80A into 50g of mixed solvent of dimethylformamide and ethanol at the temperature of 75 ℃, and stirring for 2.5 hours to fully dissolve the polyurethane particles to obtain a polyurethane solution; wherein the mass ratio of the dimethylformamide to the ethanol is 3: 2;
(2) adding 1g of polyethylene glycol 600 into the polyurethane solution obtained in the step (1), stirring for 3 hours for chemical reaction, and then placing in a vacuum drying oven for normal-temperature defoaming for 6 hours to obtain a modified polyurethane solution; wherein the mass ratio of the polyurethane particles, the mixed solvent and the polyethylene glycol 400 is 0.1: 1: 0.02;
(3) and (3) placing the modified polyurethane solution obtained in the step (2) in a forced air drying oven at 70 ℃ for drying for 9h to obtain the high-permeability polyurethane transparent film.
The transparent polyurethane film prepared in example 2 and having high transparency was tested in parallel 3 times according to the test method of example 1, and the MVTR average value was 2978g/m 2 /24h。
Example 3
A preparation method of a high-permeability polyurethane transparent film comprises the following steps:
(1) adding 10g of polyurethane particles with the hardness of 90A into 50g of mixed solvent of dimethylformamide and ethanol at 85 ℃, and stirring for 4 hours to fully dissolve the polyurethane particles to obtain a polyurethane solution; wherein the mass ratio of the dimethylformamide to the ethanol is 1: 1;
(2) adding 3g of polyethylene glycol 400 into the polyurethane solution obtained in the step (1), stirring for 2.5h for chemical reaction, and then placing in a vacuum drying oven for normal-temperature defoaming for 8h to obtain a modified polyurethane solution; wherein the mass ratio of the polyurethane particles, the mixed solvent and the polyethylene glycol 400 is 0.2: 1: 0.06;
(3) and (3) drying the modified polyurethane solution obtained in the step (2) in a forced air drying oven at 60 ℃ for 8h to obtain the high-permeability polyurethane transparent film.
The transparent polyurethane film prepared in example 3 and having high transparency was tested in parallel 3 times according to the test method of example 1, and the average MVTR value was 3003g/m 2 /24h。
Example 4
A preparation method of a high-permeability polyurethane transparent film comprises the following steps:
(1) adding 20g of polyurethane particles with the hardness of 85A into 50g of mixed solvent of dimethylformamide and ethanol at the temperature of 80 ℃, and stirring for 2 hours to fully dissolve the polyurethane particles to obtain a polyurethane solution; wherein the mass ratio of the dimethylformamide to the ethanol is 1: 0.25;
(2) adding 6g of polyethylene glycol 200 into the polyurethane solution obtained in the step (1), stirring for 2h for chemical reaction, and then placing in a vacuum drying oven for normal-temperature defoaming for 12h to obtain a modified polyurethane solution; wherein the mass ratio of the polyurethane particles, the mixed solvent and the polyethylene glycol 400 is 0.4: 1: 0.12;
(3) and (3) drying the modified polyurethane solution obtained in the step (2) in a forced air drying oven at 80 ℃ for 10 hours to obtain the high-permeability polyurethane transparent film.
The transparent polyurethane film prepared in example 4 was tested in parallel for 3 times according to the test method of example 1, and the average MVTR value was 2904g/m 2 /24h。
Example 5
A preparation method of a high-permeability polyurethane transparent film comprises the following steps:
(1) adding 5g of polyurethane particles with the hardness of 85A into 50g of mixed solvent of dimethylformamide and ethanol at the temperature of 80 ℃, and stirring for 2 hours to fully dissolve the polyurethane particles to obtain a polyurethane solution; wherein the mass ratio of the dimethylformamide to the ethanol is 1: 0.5;
(2) adding 0.5g of starch acetate into the polyurethane solution obtained in the step (1), stirring for 4 hours to perform chemical reaction, and then placing the mixture into a vacuum drying oven to perform normal-temperature defoaming for 8 hours to obtain a modified polyurethane solution; wherein the mass ratio of the polyurethane particles, the mixed solvent and the polyethylene glycol 400 is 0.1: 1: 0.01;
(3) and (3) drying the modified polyurethane solution obtained in the step (2) in a forced air drying oven at 60 ℃ for 9h to obtain the high-permeability polyurethane transparent film.
The transparent polyurethane film prepared in example 5 and having high transparency was tested in parallel 3 times according to the test method of example 1, and the MVTR average value was 2986g/m 2 /24h。
Example 6
A preparation method of a high-permeability polyurethane transparent film comprises the following steps:
(1) adding 15g of polyurethane particles with the hardness of 75A into 50g of mixed solvent of dimethylformamide and ethanol at 85 ℃, and stirring for 2 hours to fully dissolve the polyurethane particles to obtain a polyurethane solution; wherein the mass ratio of the dimethylformamide to the ethanol is 1: 1;
(2) adding 4.5g of polyethylene glycol 400 into the polyurethane solution obtained in the step (1), stirring for 2 hours for chemical reaction, and then placing the mixture into a vacuum drying oven for normal-temperature defoaming for 12 hours to obtain a modified polyurethane solution; wherein the mass ratio of the polyurethane particles, the mixed solvent and the polyethylene glycol 400 is 0.3: 1: 0.09;
(3) and (3) drying the modified polyurethane solution obtained in the step (2) in a forced air drying oven at 60 ℃ for 12h to obtain the high-permeability polyurethane transparent film.
The transparent polyurethane film prepared in example 6 and having high transparency was tested in parallel 3 times according to the test method of example 1, and the MVTR average value was 2432g/m 2 /24h。
As can be seen from the above examples and comparative examples, the preparation method provided by the invention has simple process, and the prepared polyurethane transparent film has high permeability.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and decorations can be made without departing from the principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.
Claims (10)
1. A preparation method of a high-permeability polyurethane transparent film comprises the following steps:
(1) mixing polyurethane particles with a mixed solvent to obtain a polyurethane solution; the mixed solvent comprises dimethylformamide and alkyl alcohol;
(2) mixing the polyurethane solution obtained in the step (1) with a hydrophilic substance, and carrying out a chemical reaction to obtain a modified polyurethane solution; the hydrophilic substance is at least one of polyethylene glycol and starch acetate;
(3) and (3) drying the modified polyurethane solution obtained in the step (2) to obtain the high-permeability polyurethane transparent film.
2. The method according to claim 1, wherein the alkyl alcohol in the step (1) comprises at least one of C1-C5 alkyl alcohols.
3. The production method according to claim 1 or 2, wherein the mass ratio of dimethylformamide to alkyl alcohol in the step (1) is 1: (0.25 to 1).
4. The preparation method according to claim 1, wherein the mixing temperature in the step (1) is 60-85 ℃ and the mixing time is 1-6 h.
5. The method according to claim 1, wherein the polyethylene glycol in the step (2) comprises at least one of polyethylene glycol 200, polyethylene glycol 400 and polyethylene glycol 600.
6. The preparation method according to claim 1, wherein the mass ratio of the polyurethane particles, the mixed solvent and the hydrophilic substance in the step (1) to the hydrophilic substance in the step (2) is (0.05-0.4): 1: (0.005-0.16).
7. The preparation method according to claim 1, wherein the temperature of the chemical reaction in the step (2) is 60-85 ℃ and the time of the chemical reaction is 0.5-4 h.
8. The preparation method according to claim 1, wherein the drying temperature in the step (3) is 60-90 ℃ and the drying time is 8-12 h.
9. The transparent polyurethane film prepared by the preparation method of any one of claims 1-8.
10. The transparent highly transparent polyurethane film of claim 9, which is used in medical dressing.
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Application publication date: 20220805 Assignee: Henan health Guangji Biotechnology Co.,Ltd. Assignor: Beijing kangyujian Medical Instrument Co.,Ltd. Contract record no.: X2024980000235 Denomination of invention: A high permeability polyurethane transparent film and its preparation method and application Granted publication date: 20230825 License type: Exclusive License Record date: 20240108 |
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