CN114834734A

CN114834734A - Platelet specificity autoantibody detection kit

Info

Publication number: CN114834734A
Application number: CN202210226541.0A
Authority: CN
Inventors: 李琼英
Original assignee: Shenzhen Sciarray Biotech Co ltd
Current assignee: Shenzhen Sciarray Biotech Co ltd
Priority date: 2022-03-09
Filing date: 2022-03-09
Publication date: 2022-08-02

Abstract

The invention discloses a platelet specific autoantibody detection kit, which comprises a kit body, lid and base, the lid passes through the hinge and rotates the installation on the box body, carry out closed locking through the hasp between box body and the lid, install the handle on the lid, the handle passes through roating seat movable mounting, the controller is installed to box body front end electricity, install the mounting groove in the box body, demountable installation has the rack in the mounting groove, install the reagent bottle on the rack, the reagent bottle below is provided with the jacking device, it is provided with first closure plate and second closure plate to lie in reagent bottle top both sides on the rack, be provided with the heat preservation around the reagent bottle, install the temperature controller in the heat preservation, the reagent bottle includes the bottle, bottle integrated into one piece all around has first slider, the reagent bottle is in the first spout of seting up on the heat preservation through first slider movable mounting, jacking device fixed mounting is on the shock attenuation board. The invention has better sealing property, can ensure the stability of the reagent and prolong the storage time.

Description

Platelet specificity autoantibody detection kit

Technical Field

The invention relates to the technical field of platelet detection, in particular to a platelet specific autoantibody detection kit.

Background

Platelets are small pieces of cytoplasm that shed from the cytoplasm of mature megakaryocytes in the bone marrow. Although megakaryocytes are the least in hematopoietic cells in the bone marrow, accounting for only 0.05% of the total number of bone marrow nucleated cells, the platelets produced by megakaryocytes are extremely important for the hemostatic function of the body. When blood is lost due to vascular trauma, the functional activity of platelets in the physiological process of hemostasis can be roughly divided into two phases: in the first stage, after the wound is generated, the blood platelets are quickly adhered to the wound and are aggregated into a mass to form a softer hemostatic plug; the second segment is primarily intended to promote blood clotting and form a firm hemostatic plug. Hemorrhagic disease is a very common disease in clinic, and if not treated with timely confirmation, can result in severe pain, severe joint damage and fatal internal bleeding leading to death, while only 30% of patients with hemorrhagic disease are diagnosed worldwide. Immune Thrombocytopenia (ITP) is the most common clinical hemorrhagic disease, accounting for about 30 percent of the total hemorrhagic disease, and the annual incidence rate of European and American countries is 5-10/10 ten thousands of people. It can occur in any age stage, including acute and chronic, with acute occurring in children and chronic occurring in adults, with the incidence of disease increasing in women under 40 years old and older, and in those over 65 years old. The clinical manifestations are characterized by ecchymosis and ecchymosis of the skin, bleeding of mucous membranes and internal organs. According to 2010 world Heyou alliance survey data, the prevalence rate of ITP is about one thousandth, and about 150 thousands of patients exist in China. ITP is an autoimmune hemorrhagic disease with reduced platelet number caused by increased platelet destruction caused by the dysfunction of the immune system of the organism, mainly because the platelet number is reduced caused by platelet destruction mediated by platelet-specific autoantibodies, and the detection of the platelet-specific autoantibodies has important clinical application value for the diagnosis of ITP.

At present, in the detection of platelet-specific autoantibodies, various reagents are commonly used, and the traditional kit has a simple structure, is difficult to ensure the storage environment of the reagents, so that the reagents are easily polluted, and the test result has deviation.

Based on this, the invention designs a platelet-specific autoantibody detection kit to solve the above problems.

Disclosure of Invention

The invention aims to provide a platelet-specific autoantibody detection kit, which aims to solve the problems that various reagents are commonly used in platelet-specific autoantibody detection in the prior art, and the conventional kit has a simple structure, is difficult to ensure the storage environment of the reagents, is easy to pollute and causes deviation of a test result.

In order to achieve the purpose, the invention provides the following technical scheme:

the platelet specificity autoantibody detection kit comprises a kit body, a kit cover and a base, wherein the kit cover is rotatably installed on the kit body through a hinge, the kit body and the kit cover are locked and closed through a lock catch, a handle is installed on the kit cover and movably installed through a rotating seat, a controller is electrically installed at the front end of the kit body, an installation clamping groove is formed in the kit body, a placing frame is detachably installed in the installation clamping groove, a reagent bottle is installed on the placing frame, a jacking device is arranged below the reagent bottle, a first closing plate and a second closing plate are arranged on the placing frame and positioned on two sides of the top end of the reagent bottle, a heat preservation layer is arranged around the reagent bottle, a temperature controller is installed in the heat preservation layer, the reagent bottle comprises a bottle body, a first sliding block is integrally formed on the periphery of the bottle body, the reagent bottle is movably installed in a first sliding groove formed in the heat preservation layer through the first sliding block, the jacking device is fixedly arranged on the damping plate.

As a further scheme of the invention, a sensor is arranged at the bottom of the reagent bottle, a receiver is arranged at the top of the jacking device, and the sensor can be in contact with the receiver for signal transmission.

As a further aspect of the present invention, a protrusion is integrally formed on the first closing plate, a groove adapted to the protrusion is integrally formed on the second closing plate, a second sliding groove is formed on the first closing plate and the second closing plate, and a second sliding block slidably mounted in the second sliding groove is integrally formed on the first closing plate and the second closing plate.

As a further aspect of the present invention, gears driven by a motor are electrically installed at the bottoms of the first closing plate and the second closing plate, tooth grooves meshed with the gears are integrally formed at the bottoms of the first closing plate and the second closing plate, and the gears are driven by the motor to drive the first closing plate and the second closing plate to move back and forth.

As a further scheme of the present invention, the base is rotatably mounted at the bottom of the box body 1 through a rotating base, and the rotating range is 360 °.

As a further scheme of the invention, a sterilization pad is arranged in the box cover.

As a further scheme of the invention, a control key is arranged on one side of the reagent bottle on the placing frame, and the control key controls the lifting of the jacking device.

As a further scheme of the invention, a label box is arranged on one side of the reagent bottle on the placing frame, and label paper is arranged in the label box.

Compared with the prior art, the invention has the beneficial effects that:

the platelet-specific autoantibody detection kit is provided with a box body and a box cover, wherein a placing frame is arranged in the box body, a reagent bottle is arranged in the placing frame, and a lifting device is arranged at the bottom of the reagent bottle and can be controlled by a control key to lift. When the lifting device is lifted, the reagent bottle can be ejected out for sampling and other operations, when the lifting device is recovered, the reagent bottle can be recovered into the box body for storage, and meanwhile, the first closing plate and the second closing plate are closed for sealing. The invention is convenient for storing and taking reagent bottles, has better sealing property, avoids influencing the stability of the reagent and ensures the accuracy of test results.

The heat-insulating layer is arranged around the reagent bottle, and the temperature controller is arranged in the heat-insulating layer and can adjust the temperature of the heat-insulating layer, so that the reagent bottle can be placed at the most suitable temperature, the stability of the reagent is ensured, and the storage time is prolonged.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings used in the description of the embodiments will be briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art that other drawings can be obtained according to the drawings without creative efforts.

FIG. 1 is a schematic overall view of a platelet-specific autoantibody detection kit according to the invention;

FIG. 2 is a schematic front view of a platelet-specific autoantibody detection kit according to the invention;

FIG. 3 is a schematic diagram of the internal structure of the platelet-specific autoantibody detection kit according to the invention;

FIG. 4 is a schematic partial structure view of a platelet-specific autoantibody detection kit according to the present invention;

FIG. 5 is a schematic partial structure view of a platelet-specific autoantibody detection kit according to the present invention;

FIG. 6 is a partial structural view of the platelet-specific autoantibody detection kit according to the invention.

In the drawings, the components represented by the respective reference numerals are listed below:

1. a box body; 2. a box cover; 3. a hinge; 4. locking; 5. a base; 6. placing a rack; 7. installing a clamping groove; 8. a reagent bottle; 9. a control key; 10. a label box; 11. a controller; 12. sterilizing the pad; 13. a handle; 14. rotating the base; 15. a first closure panel; 16. a second closure panel; 17. a heat-insulating layer; 18. a bottle body; 19. a first chute; 20. a first slider; 21. a temperature controller; 22. a jacking device; 23. a damper plate; 24. a rotating seat; 25. a sensor; 26. a receiver; 27. a protrusion; 28. a groove; 29. a gear; 30. a tooth socket; 31. a second chute; 32. a second slider.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

In the description of the present invention, it should be noted that the terms "top", "bottom", "one side", "the other side", "front", "back", "middle part", "inside", "top", "bottom", etc. indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience of describing the present invention and simplifying the description, but do not indicate or imply that the referred device or element must have a specific orientation, be constructed in a specific orientation, and be operated, and thus, should not be construed as limiting the present invention; the terms "first," "second," and "third" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance; furthermore, unless expressly stated or limited otherwise, the terms "mounted," "connected," and "connected" are to be construed broadly, as they may be fixedly connected, detachably connected, or integrally connected, for example; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.

As shown in FIGS. 1 to 6, the present invention provides a platelet-specific autoantibody detection kit, wherein,

FIG. 1 is a schematic overall view of a platelet-specific autoantibody detection kit according to the invention; FIG. 2 is a schematic front view of a platelet-specific autoantibody detection kit according to the invention; FIG. 3 is a schematic diagram of the internal structure of the platelet-specific autoantibody detection kit according to the invention; FIG. 4 is a schematic partial structure view of a platelet-specific autoantibody detection kit according to the present invention; FIG. 5 is a schematic partial structure view of a platelet-specific autoantibody detection kit according to the present invention; FIG. 6 is a partial structural view of the platelet-specific autoantibody detection kit according to the present invention, as can be seen from FIGS. 1 to 6,

a platelet-specific autoantibody detection kit comprises a kit body 1, a kit cover 2 and a base 5, wherein the kit cover 2 is rotatably installed on the kit body 1 through a hinge 3, the kit body 1 and the kit cover 2 are locked and closed through a lock catch 4, a handle 13 is installed on the kit cover 2, the handle 13 is movably installed through a rotating seat 14, a controller 11 is electrically installed at the front end of the kit body 1, an installation clamping groove 7 is formed in the kit body 1, a placing frame 6 is detachably installed in the installation clamping groove 7, a reagent bottle 8 is installed on the placing frame 6, a jacking device 22 is arranged below the reagent bottle 8, a first closing plate 15 and a second closing plate 16 are arranged on the placing frame 6 and positioned at two sides of the top end of the reagent bottle 8, a heat insulation layer 17 is arranged around the reagent bottle 8, a temperature controller 21 is installed in the heat insulation layer 17, the reagent bottle 8 comprises a bottle body 18, the periphery of the bottle body 18 is integrally formed with a first sliding block 20, the reagent bottle 8 is movably mounted in a first sliding groove 19 formed in the heat-insulating layer 17 through the first sliding block 20, and the jacking device 22 is fixedly mounted on a damping plate 23.

The bottom of the reagent bottle 8 is provided with a sensor 25, the top of the jacking device 22 is provided with a receiver 26, and the sensor 25 can be in contact with the receiver 26 for signal transmission. The integrated into one piece has arch 27 on the first closure plate 15, integrated into one piece have on the second closure plate 16 with the recess 28 of protruding 27 adaptation, first closure plate 15 with second closure plate 16 is last to have seted up second spout 32, first closure plate 15 with integrated into one piece has slidable mounting to be in on the second closure plate 16 the second slider 32 in the second spout 31. The bottom of the first closing plate 15 and the bottom of the second closing plate 16 are both electrically provided with a gear 29 driven by a motor, the bottom of the first closing plate 15 and the bottom of the second closing plate 16 are integrally formed with a tooth groove 30 meshed with the gear 29, and the gear 29 is driven by the motor to drive the first closing plate 15 and the second closing plate 16 to move back and forth. The base 5 is rotatably installed at the bottom of the box body 1 through a rotating seat 24, and the rotating range is 360 degrees. The box cover 2 is internally provided with a sterilization pad 12. A control key 9 is arranged on one side of the reagent bottle 8 on the placing frame 6, and the control key 9 controls the lifting of the jacking device 22. A label box 10 is arranged on one side of the reagent bottle 8 on the placing frame 6, and label paper is arranged in the label box 10.

In practical application, the lock catch 4 is opened, the jacking device 22 is controlled to lift through the control button 9, when the jacking device 22 is started, the gear 29 driven by the motor to rotate can drive the first plywood 15 and the second closing board 16 to move towards two sides for opening, the reagent bottle 8 is lifted, and medical staff can take out the reagent. The retraction is controlled by the control button 9 after use is completed. Meanwhile, during the use of the device, the internal temperature controller 21 can detect the temperature of the heat-insulating layer 17 in the device, and the feedback controller 11 and the temperature controller 21 can perform heating or cooling treatment to maintain the internal temperature stable.

The platelet-specific autoantibody detection kit is provided with a box body and a box cover, wherein a placing frame is arranged in the box body, a reagent bottle is arranged in the placing frame, and a lifting device is arranged at the bottom of the reagent bottle and can be controlled by a control key to lift. When the lifting device lifts, the reagent bottles can be ejected out for sampling and other operations, and when the lifting device recovers, the reagent bottles can be recovered into the box body for storage, and meanwhile, the first closing plate and the second closing plate are closed for sealing. The invention is convenient for storing and taking reagent bottles, has better sealing performance and avoids influencing the stability of reagents. The heat-insulating layer is arranged around the reagent bottle, and the temperature controller is arranged in the heat-insulating layer and can adjust the temperature of the heat-insulating layer, so that the reagent bottle can be placed at the most suitable temperature, the stability of the reagent is ensured, and the storage time is prolonged.

The preferred embodiments of the invention disclosed above are intended to be illustrative only. The preferred embodiments are not intended to be exhaustive or to limit the invention to the precise embodiments disclosed. Obviously, many modifications and variations are possible in light of the above teaching. The embodiments were chosen and described in order to best explain the principles of the invention and the practical application, to thereby enable others skilled in the art to best utilize the invention. The invention is limited only by the claims and their full scope and equivalents.

Claims

1. The platelet specificity autoantibody detection kit comprises a kit body (1), a kit cover (2) and a base (5), and is characterized in that the kit cover (2) is rotatably installed on the kit body (1) through a hinge (3), the kit body (1) and the kit cover (2) are locked in a closed manner through a lock catch (4), a handle (13) is installed on the kit cover (2), the handle (13) is movably installed through a rotating seat (14), a controller (11) is electrically installed at the front end of the kit body (1), an installation clamping groove (7) is formed in the kit body (1), a placing frame (6) is detachably installed in the installation clamping groove (7), a reagent bottle (8) is installed on the placing frame (6), a jacking device (22) is arranged below the reagent bottle (8), a first closing plate (15) and a second closing plate (16) are arranged on two sides of the top end of the reagent bottle (8) on the placing frame (6), be provided with heat preservation (17) around reagent bottle (8), install temperature controller (21) in heat preservation (17), reagent bottle (8) are including bottle (18), bottle (18) integrated into one piece all around has first slider (20), reagent bottle (8) pass through first slider (20) movable mounting be in first spout (19) seted up on heat preservation (17), jacking device (22) fixed mounting is on damper plate (23).

2. The platelet-specific autoantibody detection kit according to claim 1, characterized in that a sensor (25) is mounted at the bottom of the reagent bottle (8), a receiver (26) is mounted at the top of the lifting device (22), and the sensor (25) can be in contact with the receiver (26) for signal transmission.

3. The platelet-specific autoantibody detection kit according to claim 1, wherein the first closing plate (15) is integrally formed with a protrusion (27), the second closing plate (16) is integrally formed with a groove (28) adapted to the protrusion (27), the first closing plate (15) and the second closing plate (16) are provided with a second sliding groove (32), and the first closing plate (15) and the second closing plate (16) are integrally formed with a second slider (32) slidably mounted in the second sliding groove (31).

4. The platelet-specific autoantibody detection kit according to claim 1, wherein a motor-driven gear (29) is electrically mounted at the bottom of each of the first closing plate (15) and the second closing plate (16), a toothed groove (30) meshed with the gear (29) is integrally formed at the bottom of each of the first closing plate (15) and the second closing plate (16), and the gear (29) is driven by a motor to drive the first closing plate (15) and the second closing plate (16) to move back and forth.

5. The platelet-specific autoantibody detection kit according to claim 1, characterized in that the base (5) is rotatably mounted to the bottom of the cartridge body (1) by a rotary base (24) over a 360 ° range of rotation.

6. The platelet-specific autoantibody detection kit according to claim 1, characterized in that a sterile pad (12) is mounted in the lid (2).

7. The platelet-specific autoantibody detection kit according to claim 1, characterized in that a control button (9) is provided on the rack (6) on one side of the reagent bottle (8), and the control button (9) controls the lifting of the lifting device (22).

8. The platelet-specific autoantibody detection kit according to claim 1, characterized in that a label box (10) is provided on the rack (6) on one side of the reagent bottle (8), and a label paper is provided in the label box (10).