CN114795972A - Medical enhanced nano composite material and preparation method thereof - Google Patents
Medical enhanced nano composite material and preparation method thereof Download PDFInfo
- Publication number
- CN114795972A CN114795972A CN202210380353.3A CN202210380353A CN114795972A CN 114795972 A CN114795972 A CN 114795972A CN 202210380353 A CN202210380353 A CN 202210380353A CN 114795972 A CN114795972 A CN 114795972A
- Authority
- CN
- China
- Prior art keywords
- weight
- parts
- nano
- medical
- composite material
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000463 material Substances 0.000 title claims abstract description 32
- 239000002114 nanocomposite Substances 0.000 title claims abstract description 26
- 238000002360 preparation method Methods 0.000 title description 7
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 42
- 239000000945 filler Substances 0.000 claims abstract description 32
- 230000000844 anti-bacterial effect Effects 0.000 claims abstract description 30
- 239000011347 resin Substances 0.000 claims abstract description 22
- 229920005989 resin Polymers 0.000 claims abstract description 22
- 239000002245 particle Substances 0.000 claims abstract description 19
- 235000012239 silicon dioxide Nutrition 0.000 claims abstract description 17
- 239000011159 matrix material Substances 0.000 claims abstract description 13
- 229910052732 germanium Inorganic materials 0.000 claims abstract description 11
- GNPVGFCGXDBREM-UHFFFAOYSA-N germanium atom Chemical compound [Ge] GNPVGFCGXDBREM-UHFFFAOYSA-N 0.000 claims abstract description 11
- 229910052746 lanthanum Inorganic materials 0.000 claims abstract description 11
- FZLIPJUXYLNCLC-UHFFFAOYSA-N lanthanum atom Chemical compound [La] FZLIPJUXYLNCLC-UHFFFAOYSA-N 0.000 claims abstract description 11
- SOQBVABWOPYFQZ-UHFFFAOYSA-N oxygen(2-);titanium(4+) Chemical compound [O-2].[O-2].[Ti+4] SOQBVABWOPYFQZ-UHFFFAOYSA-N 0.000 claims abstract description 9
- 239000000843 powder Substances 0.000 claims abstract description 8
- 238000003756 stirring Methods 0.000 claims description 28
- 239000000203 mixture Substances 0.000 claims description 19
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 12
- 239000000377 silicon dioxide Substances 0.000 claims description 8
- 239000002131 composite material Substances 0.000 claims description 6
- 239000011265 semifinished product Substances 0.000 claims description 6
- 239000004408 titanium dioxide Substances 0.000 claims description 5
- 230000000845 anti-microbial effect Effects 0.000 claims description 4
- 238000000498 ball milling Methods 0.000 claims description 3
- 238000001035 drying Methods 0.000 claims description 3
- 239000000047 product Substances 0.000 claims description 3
- 238000007873 sieving Methods 0.000 claims description 3
- 238000000034 method Methods 0.000 claims 2
- 239000005543 nano-size silicon particle Substances 0.000 abstract description 13
- 239000000805 composite resin Substances 0.000 abstract description 7
- 238000011049 filling Methods 0.000 abstract description 5
- 238000000016 photochemical curing Methods 0.000 abstract description 3
- 241000222122 Candida albicans Species 0.000 abstract description 2
- 241000588724 Escherichia coli Species 0.000 abstract description 2
- 241000191967 Staphylococcus aureus Species 0.000 abstract description 2
- 229940095731 candida albicans Drugs 0.000 abstract description 2
- 230000002401 inhibitory effect Effects 0.000 abstract description 2
- 239000011521 glass Substances 0.000 description 3
- 150000002500 ions Chemical class 0.000 description 3
- 229910000645 Hg alloy Inorganic materials 0.000 description 2
- CBBVHSHLSCZIHD-UHFFFAOYSA-N mercury silver Chemical compound [Ag].[Hg] CBBVHSHLSCZIHD-UHFFFAOYSA-N 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 208000008010 Tooth Avulsion Diseases 0.000 description 1
- 208000004509 Tooth Discoloration Diseases 0.000 description 1
- 206010044032 Tooth discolouration Diseases 0.000 description 1
- 239000000956 alloy Substances 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000001055 chewing effect Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 210000003298 dental enamel Anatomy 0.000 description 1
- 210000004268 dentin Anatomy 0.000 description 1
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- -1 silver ions Chemical class 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000036367 tooth discoloration Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/802—Preparations for artificial teeth, for filling teeth or for capping teeth comprising ceramics
- A61K6/816—Preparations for artificial teeth, for filling teeth or for capping teeth comprising ceramics comprising titanium oxide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/884—Preparations for artificial teeth, for filling teeth or for capping teeth comprising natural or synthetic resins
Landscapes
- Health & Medical Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Plastic & Reconstructive Surgery (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Ceramic Engineering (AREA)
- Dental Preparations (AREA)
Abstract
The invention discloses a medical enhanced nano composite material, which relates to the technical field of dental repair materials and comprises 81-85 parts by weight of a resin matrix, 12-16 parts by weight of an antibacterial filler, 1-2 parts by weight of a germanium-based photoinitiator and 1-2 parts by weight of nano lanthanum, wherein the resin matrix is pre-polymerized resin powder, and the antibacterial filler comprises Ag-Tio2 antibacterial filler particles, nano silicon dioxide and nano titanium dioxide. According to the invention, the antibacterial filler is added into the resin matrix, and the antibacterial filler consists of Ag-Tio2 antibacterial filler particles, nano silicon dioxide and nano titanium dioxide, so that the medical enhanced nano composite material has the functions of inhibiting and killing escherichia coli, staphylococcus aureus and candida albicans, and has hardness higher than that of the existing photocuring composite resin dental filling material.
Description
Technical Field
The invention relates to the technical field of dental prosthetic materials, in particular to a medical enhanced nano composite material and a preparation method thereof.
Background
Teeth are important hard tissues of human body and have functions of chewing and the like. Teeth are composed primarily of dentin, the inner layer, and enamel, the major inorganic component being hydroxyapatite.
If the tooth is damaged, the tooth needs to be filled. The decayed tooth is also called as a carious cavity, which means that the complete tooth surface is damaged and decayed due to bacterial plaque and bacteria, if the tooth is not filled, the carious cavity is enlarged, the decayed tooth reaches the dental nerve and even the tooth generates a residual root and a residual crown, and finally the tooth needs to be pulled out, so the tooth is filled in time, and the materials of the tooth filling at present mainly comprise silver mercury alloy materials, glass ion materials and composite resin materials.
Silver-mercury alloy: is a mixture of silver ions and free mercury, becomes hard after 12 hours, and is a traditional material. Is firmer and has stronger durability, but the color is not beautiful. Is gradually eliminated by the market.
Glass ion type material: glass ions are generally applied to unstressed parts such as buccal sides and root surfaces of teeth, and have good adhesion, but poor color and strength. Therefore, the filling of anterior teeth and occlusal surfaces is not generally used.
Light-cured composite resin material: is a resin material which becomes hard after photo-curing, and is most commonly used at present.
The light-cured composite resin dental filling is mainly used for repairing the symptoms of tooth discoloration, defects, broken teeth, decayed teeth, deformed small teeth, individual tooth dislocation and the like. Although the photo-curable composite resin dental prosthesis is relatively inexpensive and convenient to handle, the photo-curable composite resin dental prosthesis does not have an antibacterial function and has poor hardness.
Therefore, a medical enhanced nano composite material and a preparation method thereof are provided.
Disclosure of Invention
The invention aims to solve the problems in the background art and provides a medical reinforced nano composite material and a preparation method thereof.
In order to achieve the purpose, the invention adopts the following technical scheme:
a medical enhanced nano composite material comprises 81-85 parts by weight of a resin matrix, 12-16 parts by weight of an antibacterial filler, 1-2 parts by weight of a germanium-based photoinitiator and 1-2 parts by weight of nano lanthanum.
Preferably, the resin matrix is a pre-polymerized resin powder having a particle size of 0.8-1 μm.
Preferably, the antimicrobial filler includes Ag-Tio2 antimicrobial filler particles.
Preferably, the antibacterial filler further comprises nano silicon dioxide, and the particle size of the nano silicon dioxide is 2-50 nm.
Preferably, the antibacterial filler also comprises nano titanium dioxide, and the particle size of the nano titanium dioxide is 50-100 nm.
Preferably, the ratio of the Ag-Tio2 antibacterial filler particles to the nano silicon dioxide to the nano titanium dioxide is 3:2: 2.
Preferably, the antibacterial coating comprises 83 parts by weight of resin matrix, 9 parts by weight of antibacterial filler, 1.5 parts by weight of germanium-based photoinitiator, 3 parts by weight of silicon dioxide, 2 parts by weight of titanium dioxide and 1.5 parts by weight of nano lanthanum.
A preparation method of a medical enhanced nano composite material comprises the following steps:
step 1, putting a certain weight part of resin matrix, silicon dioxide and titanium dioxide into a stirrer for stirring, and uniformly stirring to obtain a mixture A;
step 2, adding a certain weight part of germanium-based photoinitiator into the mixture A, stirring, and uniformly stirring to obtain a mixture B;
step 3, adding a certain weight part of antibacterial filler into the mixture B, stirring, and uniformly stirring to obtain a mixture C;
step 4, adding a certain weight part of nano lanthanum into the mixture C, stirring, and uniformly stirring to obtain a composite material semi-finished product;
and 5, performing circular crushing treatment, ball milling treatment, drying treatment and sieving treatment on the composite material semi-finished product to obtain a medical enhanced nano composite material finished product.
Preferably, the stirring treatment in step 1, step 2, step 3 and step 4 is carried out at 5-15 ℃, and the stirring time is 2-7 h.
Compared with the prior art, the invention has the beneficial effects that:
according to the invention, the antibacterial filler is added into the resin matrix, and the antibacterial filler consists of Ag-Tio2 antibacterial filler particles, nano silicon dioxide and nano titanium dioxide, so that the medical enhanced nano composite material has the functions of inhibiting and killing escherichia coli, staphylococcus aureus and candida albicans, and has hardness higher than that of the existing photocuring composite resin dental filling material.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments.
Example one
A medical enhanced nano composite material comprises 82 parts by weight of pre-polymerized resin powder, 14 parts by weight of an antibacterial filler, 2 parts by weight of a germanium-based photoinitiator and 2 parts by weight of nano lanthanum, wherein 6 parts by weight of Ag-Tio2 antibacterial filler particles, 4 parts by weight of nano silicon dioxide and 4 parts by weight of nano silicon dioxide.
Example two
A medical enhanced nano composite material comprises 84 parts by weight of pre-polymerized resin powder, 14 parts by weight of an antibacterial filler, 1 part by weight of a germanium-based photoinitiator and 1 part by weight of nano lanthanum, wherein 6 parts by weight of Ag-Tio2 antibacterial filler particles, 4 parts by weight of nano silicon dioxide and 4 parts by weight of nano silicon dioxide.
EXAMPLE III
A medical enhanced nano composite material comprises 83 parts by weight of pre-polymerized resin powder, 14 parts by weight of an antibacterial filler, 2 parts by weight of a germanium-based photoinitiator and 1 part by weight of nano lanthanum, wherein 6 parts by weight of Ag-Tio2 antibacterial filler particles, 4 parts by weight of nano silicon dioxide and 4 parts by weight of nano silicon dioxide.
In the present invention, more specifically, the particle diameter of the prepolymerized resin powder is 0.8 to 1 μm.
In the invention, more specifically, the particle size of the nano silicon dioxide is 2-50 nm.
In the invention, more specifically, the particle size of the nano titanium dioxide is 50-100 nm.
A preparation method of a medical enhanced nano composite material comprises the following steps:
step 1, putting a certain weight part of resin matrix, silicon dioxide and titanium dioxide into a stirrer for stirring, and uniformly stirring to obtain a mixture A;
step 2, adding a certain weight part of germanium-based photoinitiator into the mixture A, stirring, and uniformly stirring to obtain a mixture B;
step 3, adding a certain weight part of antibacterial filler into the mixture B, stirring, and uniformly stirring to obtain a mixture C;
step 4, adding a certain weight part of nano lanthanum into the mixture C, stirring, and obtaining a semi-finished product of the composite material after uniformly stirring;
and 5, performing circular crushing treatment, ball milling treatment, drying treatment and sieving treatment on the composite material semi-finished product to obtain a medical enhanced nano composite material finished product.
In the present invention, more specifically, the stirring treatment in step 1, step 2, step 3 and step 4 is performed at 5-15 ℃ for 2-7 h.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.
Claims (9)
1. The medical enhanced nano composite material is characterized by comprising 81-85 parts by weight of resin matrix, 12-16 parts by weight of antibacterial filler, 1-2 parts by weight of germanium-based photoinitiator and 1-2 parts by weight of nano lanthanum.
2. The medical reinforced nanocomposite according to claim 1, wherein the resin matrix is pre-polymerized resin powder, and the particle size of the pre-polymerized resin powder is 0.8 to 1 μm.
3. The medical reinforced nanocomposite of claim 1, wherein the antimicrobial filler comprises Ag-Tio2 antimicrobial filler particles.
4. The medical enhancement type nano composite material as claimed in claim 3, wherein the antibacterial filler further comprises nano silica, and the particle size of the nano silica is 2-50 nm.
5. The medical enhancement type nano composite material is characterized in that the antibacterial filler also comprises nano titanium dioxide, and the particle size of the nano titanium dioxide is 50-100 nm.
6. The medical reinforced nanocomposite as claimed in claim 5, wherein the ratio of the Ag-Tio2 antibacterial filler particles to the nano silica to the nano titania is 3:2: 2.
7. The medical reinforced nanocomposite as claimed in claim 1, comprising 83 parts by weight of resin matrix, 9 parts by weight of antibacterial filler, 1.5 parts by weight of germanium-based photoinitiator, 3 parts by weight of silica, 2 parts by weight of titanium dioxide and 1.5 parts by weight of nano lanthanum.
8. The method for preparing the medical reinforced nanocomposite material according to any one of claims 1 to 7, comprising the following steps:
step 1, putting a certain weight part of resin matrix, silicon dioxide and titanium dioxide into a stirrer for stirring, and uniformly stirring to obtain a mixture A;
step 2, adding a certain weight part of germanium-based photoinitiator into the mixture A, stirring, and obtaining a mixture B after uniformly stirring;
step 3, adding a certain weight part of antibacterial filler into the mixture B, stirring, and uniformly stirring to obtain a mixture C;
step 4, adding a certain weight part of nano lanthanum into the mixture C, stirring, and uniformly stirring to obtain a composite material semi-finished product;
and 5, performing circular crushing treatment, ball milling treatment, drying treatment and sieving treatment on the composite material semi-finished product to obtain a medical enhanced nano composite material finished product.
9. The method for preparing the medical reinforced nanocomposite as claimed in claim 8, wherein the stirring treatment in the steps 1, 2, 3 and 4 is performed at 5-15 ℃ for 2-7 h.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210380353.3A CN114795972A (en) | 2022-04-12 | 2022-04-12 | Medical enhanced nano composite material and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210380353.3A CN114795972A (en) | 2022-04-12 | 2022-04-12 | Medical enhanced nano composite material and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114795972A true CN114795972A (en) | 2022-07-29 |
Family
ID=82533744
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210380353.3A Pending CN114795972A (en) | 2022-04-12 | 2022-04-12 | Medical enhanced nano composite material and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114795972A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106823004A (en) * | 2016-12-09 | 2017-06-13 | 桂林加宏汽车修理有限公司 | A kind of composite dental repair materials |
| CN107411974A (en) * | 2017-05-26 | 2017-12-01 | 日照沪鸽生物材料有限公司 | The preparation method of the filler powder with nanostructured of dentistry composite resin filler |
| CN108014021A (en) * | 2016-11-29 | 2018-05-11 | 北京安泰生物医用材料有限公司 | A kind of tooth filling renovation material and preparation method thereof |
| CN113975182A (en) * | 2021-11-17 | 2022-01-28 | 深圳市尚美尔技术研发有限公司 | Antibacterial tooth filling material and preparation method thereof |
-
2022
- 2022-04-12 CN CN202210380353.3A patent/CN114795972A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108014021A (en) * | 2016-11-29 | 2018-05-11 | 北京安泰生物医用材料有限公司 | A kind of tooth filling renovation material and preparation method thereof |
| CN106823004A (en) * | 2016-12-09 | 2017-06-13 | 桂林加宏汽车修理有限公司 | A kind of composite dental repair materials |
| CN107411974A (en) * | 2017-05-26 | 2017-12-01 | 日照沪鸽生物材料有限公司 | The preparation method of the filler powder with nanostructured of dentistry composite resin filler |
| CN113975182A (en) * | 2021-11-17 | 2022-01-28 | 深圳市尚美尔技术研发有限公司 | Antibacterial tooth filling material and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| McLean et al. | Glass-cermet cements. | |
| Park et al. | Current aspects and prospects of glass ionomer cements for clinical dentistry | |
| US20170014206A1 (en) | Dental veneers and methods of manufacture | |
| Zafar et al. | Therapeutic applications of nanotechnology in dentistry | |
| US20030167967A1 (en) | Glass ionomers for enhancing mineralization of hard tissue | |
| Najeeb et al. | Nano glass ionomer cement: Modification for biodental applications | |
| Fink | Materials, chemicals and methods for dental applications | |
| CN114795972A (en) | Medical enhanced nano composite material and preparation method thereof | |
| Tyliszczak et al. | Acrylates in dental applications | |
| Rao et al. | Scope of biomaterials in conservative dentistry and endodontics | |
| US20180333236A1 (en) | Method for duplicating a denture | |
| Wren | Vitreous materials for dental restoration and reconstruction | |
| Mathur et al. | Restorative materials used in pediatric dentistry | |
| KR101689535B1 (en) | Composite Resin | |
| Kerezoudi et al. | Nanobiomaterials in restorative dentistry | |
| Hussaen | Bioactive Restorative Materials A Literature Review | |
| Xu et al. | Nano Structured Materials in Dental Medicine—From Laboratory to Industry: New Opportunities, Challenges and Risks | |
| Poursamad et al. | Studying and Investigating the Capacity of Dental Prostheses to Increase the Bond Strength of Ceramic Restorations (Case Study) | |
| Flucke | Bioactive restorative dental materials hold great promise in terms of function, use | |
| Rinastiti | Biomaterials in dentistry | |
| KR101837721B1 (en) | resin composition for temporary crown and manufacturing method of polymer for temporary crown | |
| SONI et al. | Dental Application of Properties of Smart Materials | |
| Al Wadei | A KNOWLEDGE ATTITUDE AND OPINION TOWARDS BIOMIMETIC MATERIALS USED IN CONSERVATIVE DENTISTRY AND ENDODONTICS AMONG DENTISTS | |
| Melo et al. | BIOACTIVE RESINS: GOING BEYOND ESTHETICS AND FUNCTIONALITY? | |
| Almahamidhi et al. | Composite Materials In Dentistry: A Comprehensive Overview |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20220729 |
|
| RJ01 | Rejection of invention patent application after publication |