CN114786669A - 用于1p36缺失综合征的治疗性治疗的加波沙朵 - Google Patents

用于1p36缺失综合征的治疗性治疗的加波沙朵 Download PDF

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Publication number
CN114786669A
CN114786669A CN202080085811.XA CN202080085811A CN114786669A CN 114786669 A CN114786669 A CN 114786669A CN 202080085811 A CN202080085811 A CN 202080085811A CN 114786669 A CN114786669 A CN 114786669A
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CN
China
Prior art keywords
gaboxadol
pharmaceutically acceptable
acceptable salt
day
drug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202080085811.XA
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English (en)
Chinese (zh)
Inventor
马修·杜林
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ovid Therapeutics Inc
Original Assignee
Ovid Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ovid Therapeutics Inc filed Critical Ovid Therapeutics Inc
Publication of CN114786669A publication Critical patent/CN114786669A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
CN202080085811.XA 2019-12-18 2020-12-18 用于1p36缺失综合征的治疗性治疗的加波沙朵 Pending CN114786669A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962949551P 2019-12-18 2019-12-18
US62/949,551 2019-12-18
PCT/US2020/065801 WO2021127308A1 (en) 2019-12-18 2020-12-18 GABOXADOL FOR THERAPEUTIC TREATMENT OF 1p36 DELETION SYNDROME

Publications (1)

Publication Number Publication Date
CN114786669A true CN114786669A (zh) 2022-07-22

Family

ID=76439052

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202080085811.XA Pending CN114786669A (zh) 2019-12-18 2020-12-18 用于1p36缺失综合征的治疗性治疗的加波沙朵

Country Status (10)

Country Link
US (1) US11364228B2 (https=)
EP (1) EP4051272A4 (https=)
JP (1) JP2023507764A (https=)
KR (1) KR20220114572A (https=)
CN (1) CN114786669A (https=)
AU (1) AU2020405060A1 (https=)
CA (1) CA3164635A1 (https=)
IL (1) IL293924A (https=)
MX (1) MX2022007715A (https=)
WO (1) WO2021127308A1 (https=)

Citations (3)

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Publication number Priority date Publication date Assignee Title
US20150352085A1 (en) * 2014-06-06 2015-12-10 Ovid Therapeutics Inc. Methods of increasing tonic inhibition and treating secondary insomnia
US20170037475A1 (en) * 2014-04-09 2017-02-09 Lineagen, Inc. Genetic markers associated with asd and other childhood developmental delay disorders
US20190038606A1 (en) * 2017-08-04 2019-02-07 Ovid Therapeutics Inc. Use of gaboxadol in the treatment of diabetes and related conditions

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US20020165217A1 (en) 2001-05-01 2002-11-07 Pfizer Inc. Combination treatment for anxiety and depression
BRPI0410857A (pt) 2003-06-25 2006-07-04 Lundbeck & Co As H método para o tratamento de depressão, uso de gaboxadol, e, composição farmacêutica
US20050234093A1 (en) 2003-06-25 2005-10-20 H. Lundbeck A/S Treatment of depression and other affective disorders
US20070032553A1 (en) 2003-09-10 2007-02-08 Mckernan Ruth Use of gabaa receptor agonists for the treatment of hearing, vestibular and attention disorders, intention tremor and restless leg syndrome
TW200528098A (en) 2003-12-18 2005-09-01 Lundbeck & Co As H Treatment of insomnia in human patients
US20050137222A1 (en) 2003-12-18 2005-06-23 H. Lundbeck A/S Treatment of insomnia in human patients
GB0402118D0 (en) 2004-01-30 2004-03-03 Merck Sharp & Dohme Polymorphic forms of a GABAA agonist
JP2007530604A (ja) 2004-04-02 2007-11-01 ハー・ルンドベック・アクチエゼルスカベット 呼吸機能障害の治療
GB0417558D0 (en) 2004-08-06 2004-09-08 Merck Sharp & Dohme Novel combination therapy
EP1848420A4 (en) 2005-01-28 2008-01-23 Merck & Co Inc POLYMORPH SHAPES OF A GABAA AGONIST
US20080262029A1 (en) 2005-04-29 2008-10-23 H. Lundbeck A/S Acid and Base Salt Forms of Gaboxadol
DE102005020882A1 (de) 2005-05-04 2006-11-09 Dömling, Alexander, Dr. Verwendung von Gaboxadol und Derivaten zur Behandlung von Kinase-induzierten Krankheiten
US20110046090A1 (en) 2005-10-31 2011-02-24 Braincells Inc. Modulation of neurogenesis with gaba agents and gaba analogs
AU2006308889A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. GABA receptor mediated modulation of neurogenesis
US20090269795A1 (en) 2007-03-09 2009-10-29 The Research Foundation Of State University Of New York Mutant alpha4betadelta GABAA receptor and methods of treating anxiety or irritability
US20090048288A1 (en) 2007-08-13 2009-02-19 H. Lundbeck A/S Method of treating stress-mediated depression
TW200920358A (en) 2007-08-13 2009-05-16 Lundbeck & Co As H Method of treating stress-mediated depression
US20090143335A1 (en) 2007-10-29 2009-06-04 H. Lundbeck A/S Modified absorption formulation of gaboxadol
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WO2014123909A1 (en) 2013-02-05 2014-08-14 University Of Washington Through Its Center For Commercialization Positive allosteric modulators of the gaba-a receptor in the treatment of autism
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EP4541420A3 (en) * 2015-07-17 2025-06-25 Ovid Therapeutics Inc. Methods of treating developmental disorders with gaboxadol
US9399034B1 (en) 2015-08-11 2016-07-26 Ovid Therapeutics Inc Methods of sedation during critical care treatment
EP3481387A4 (en) 2016-08-11 2020-04-08 Ovid Therapeutics Inc METHOD AND COMPOSITIONS FOR TREATING EPILEPTIC DISEASES
US10071083B2 (en) * 2017-02-03 2018-09-11 Ovid Therapeutics Inc Use of gaboxadol in the treatment of tinnitus

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170037475A1 (en) * 2014-04-09 2017-02-09 Lineagen, Inc. Genetic markers associated with asd and other childhood developmental delay disorders
US20150352085A1 (en) * 2014-06-06 2015-12-10 Ovid Therapeutics Inc. Methods of increasing tonic inhibition and treating secondary insomnia
US20190038606A1 (en) * 2017-08-04 2019-02-07 Ovid Therapeutics Inc. Use of gaboxadol in the treatment of diabetes and related conditions

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
M. GRECO等: "Electroclinical features of epilepsy associated with 1p36 deletion syndrome: A review", 《EPILEPSY RESEARCH》, vol. 139, pages 92 - 101 *

Also Published As

Publication number Publication date
WO2021127308A1 (en) 2021-06-24
MX2022007715A (es) 2022-07-19
KR20220114572A (ko) 2022-08-17
EP4051272A4 (en) 2023-01-04
US20210186938A1 (en) 2021-06-24
CA3164635A1 (en) 2021-06-24
US11364228B2 (en) 2022-06-21
IL293924A (en) 2022-08-01
EP4051272A1 (en) 2022-09-07
JP2023507764A (ja) 2023-02-27
AU2020405060A1 (en) 2022-06-09

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Application publication date: 20220722