CN114778203A

CN114778203A - Acute kidney injury early prediction method and device

Info

Publication number: CN114778203A
Application number: CN202210516903.XA
Authority: CN
Inventors: 刘敏; 上官丹罡; 肖坚; 陈文航; 周明
Original assignee: Xiangya Hospital of Central South University
Current assignee: Xiangya Hospital of Central South University
Priority date: 2022-05-13
Filing date: 2022-05-13
Publication date: 2022-07-22

Abstract

The invention belongs to the technical field of kidney injury, and particularly discloses an acute kidney injury early-stage prediction device which comprises a placing box, wherein an upper cover is rotatably arranged at the upper end of the placing box, a support frame is arranged at the inner bottom of the placing box, an extraction mechanism is clamped at the upper end of the support frame, a positioning device is arranged at the lower end of the extraction mechanism in a threaded manner, and a positioning device is fixedly arranged at the corner of the upper end of the placing box, which is close to the rear side of one side. The compressed reset spring resets under the action of the elastic force of the reset spring, so that the two groups of moving blocks are driven to move towards the approaching direction, the clamping blocks are driven to clamp the collecting pipe between the two groups of clamping blocks, the collecting pipe is clamped and positioned in the mode, the mode is flexible, six groups of urine to be sampled can be stored in the reset spring by using the six groups of sampling cylinders, the aim of sampling multiple groups at one time can be fulfilled, a laboratory is not required to divide the urine of the samples, and the urine sampling device is practical.

Description

Acute kidney injury early prediction method and device

Technical Field

The invention belongs to the technical field of kidney injury, and particularly discloses an early prediction method and device of acute kidney injury.

Background

Acute kidney injury is a group of clinical syndromes, which refer to sudden (within 1-7 d) and sustained (>24h) sudden decline in renal function, defined as at least 0.5mg/dl rise in serum creatinine (SCr), manifested by azotemia, aqueous electrolyte and acid-base balance and systemic symptoms throughout the body, which may be accompanied by oliguria (<400ml/24h or 17ml/h) or anuria (<100ml/24 h);

the conventional early detection of acute kidney injury is mainly to perform routine examination of urine, one urine sample is required to be taken at a time in the urine sampling process and sent to a laboratory, and the laboratory divides one urine sample into a plurality of urine samples to respectively detect urine components including urine sodium, sodium filtration fraction, renal failure index, urine and blood seepage and serum creatinine concentration.

Disclosure of Invention

The invention aims to solve the defects in the prior art and provides an acute kidney injury early prediction method and device.

In order to achieve the purpose, the invention provides an acute kidney injury early-stage prediction device which comprises a placing box, wherein an upper cover is rotatably arranged at the upper end of the placing box, a support frame is arranged at the inner bottom of the placing box, an extraction mechanism is clamped at the upper end of the support frame, a positioning device is arranged at the lower end of the extraction mechanism in a threaded manner, and a positioning device is fixedly arranged at the corner of the upper end of the placing box, which is close to the rear side of one side.

In the above technical scheme, preferably, the extraction mechanism includes an extraction cylinder movably clamped on the inner side of the upper end of the support frame, a piston is slidably arranged in the extraction cylinder, a piston push rod is fixedly arranged at the rear end of the piston, a connecting pipe is fixedly arranged at the front end of the extraction cylinder, and the connecting pipe is communicated with the extraction cylinder.

In the above technical solution, preferably, a containing tube is arranged at the front end of the connecting tube, a position of the lower end of the containing tube close to the rear side is fixedly provided, a liquid outlet is arranged at a position of the lower end of the containing tube close to the front side, the liquid outlet is communicated with the containing tube, a stop block is arranged inside the containing tube close to the bottom of the rear side, the stop block is semicircular, and an outer circular surface of the stop block is attached to an inner circular surface of the containing tube.

In the above technical scheme, preferably, the accommodating mechanism includes a lower end in threaded connection with the liquid outlet, a collecting pipe is fixedly arranged at the lower end of the connecting internal thread pipe, the collecting pipe and the connecting internal thread pipe are in a fixed communicating relation, and six groups of fixing holes arranged in a circular array are formed in the upper end inclined plane of the collecting pipe.

In the above technical scheme, preferably, the accommodating mechanism further includes a supporting disk fixedly disposed at a connection portion between the internal threaded tube and the collecting tube, an alignment clamping groove is formed in the upper end of the supporting disk, a clamping block is disposed inside the alignment clamping groove, the clamping block is adapted to the alignment clamping groove, the clamping block is movably clamped inside the alignment clamping groove, a holding disk is fixedly disposed at the upper end of the clamping block, six sets of clamping grooves arranged in a circular array are disposed inside the holding disk, and a set of clamping block is disposed inside each clamping groove.

In the above technical solution, preferably, the positioning device includes two sets of sliding grooves disposed at the upper end of the upper cover and close to the rear position, the upper end of the upper cover is provided with two placing holes near the rear corner, the two sets of sliding grooves are disposed at two sides of the placing groove, and two sets of fixedly connected limiting sliding rods are disposed inside each placing groove.

In the above technical solution, preferably, the outer side of the limiting slide bar is slidably connected with a moving block, the moving block is adapted to the sliding groove, and the moving block is slidably connected inside the sliding groove.

In the above technical solution, preferably, a clamping block is disposed at an upper end of the moving block, and a guide block is fixedly disposed at an upper end of the clamping block.

In the above technical solution, preferably, one end of the moving block is fixedly connected with a connecting rod, and the upper end of the connecting rod is fixedly provided with a driving ring.

Also provided is a method for early prediction of acute kidney injury, comprising the steps of:

s1: firstly, urine is sampled primarily by an extraction mechanism, and the urine is sampled into a collection pipe by the extraction mechanism to be stored;

s2: secondly, clamping the collecting pipe in the positioning device for fixing by opening the positioning device;

s3: finally, the urine in the collecting pipe can be thinned and separated through a plurality of groups of sampling cylinders.

Compared with the prior art, the invention has the following beneficial effects:

1. by adopting the sampling mode of the extraction mechanism, the sampling mode is firstly similar to that of an injector, the sampling is more stable, in addition, the sampling is carried out by adopting an instrument in the whole sampling process, the hands are not contacted, the sampling device is more sanitary for individuals, and the urine cannot be polluted;

2. the collecting pipe with urine inside is inserted between the two groups of clamping blocks through the guiding action of the guiding blocks, the two groups of driving rings are loosened, the compressed reset spring resets under the self elastic force action, so that the two groups of moving blocks are driven to move towards the approaching direction, the clamping blocks are driven to clamp the collecting pipe between the two groups of clamping blocks, and the collecting pipe is clamped and positioned in the mode, so that the mode is flexible, and the subsequent thinning sampling process is more stable;

3. when refining the sample, can realize six groups of urine of taking a sample through using six sampling barrels and store in reset spring's inside, can realize the purpose of disposable sample multiunit, need not the laboratory and divide the urine of sample again, it is relatively practical, in the time of in order accurately to insert six groups of sampling barrels steadily six groups of fixed orificess of the upper end of collecting pipe in addition, aim at the counterpoint draw-in groove of seting up in the upper end of supporting disk through the fixture block that will hold the lower extreme of dish, vertical direction moves down and holds the dish and can realize inserting six groups of sampling barrels in the fixed orificess, the fixture block can also accurate joint in the inside of counterpoint draw-in groove simultaneously, make the in-process device of sample more stable.

Drawings

FIG. 1 is a schematic diagram of the overall structure of an early acute renal injury prediction device according to the present invention;

FIG. 2 is a schematic diagram of the overall structure of the acute kidney injury early stage prediction device according to the present invention;

fig. 3 is a schematic partial structural view of an early acute renal injury prediction apparatus according to the present invention;

fig. 4 is a schematic view of a partial cutaway structure of an early acute renal injury prediction device provided by the invention;

FIG. 5 is a schematic view of a partial cross-sectional structure of an early acute renal injury prediction device according to the present invention;

FIG. 6 is a sectional view schematically illustrating the structure of the accommodating means of the acute kidney injury early stage prediction device according to the present invention;

FIG. 7 is an enlarged schematic view of the part A of the acute kidney injury early stage prediction device according to the present invention;

fig. 8 is an enlarged structural diagram of part B of the acute kidney injury early prediction device according to the present invention.

In the figure: 1. placing the box; 2. an upper cover; 3. a support frame; 4. an extraction mechanism; 41. an extraction cylinder; 42. a piston push rod; 43. a connecting pipe; 44. accommodating the tube; 45. a grip; 46. a liquid outlet; 47. a stopper; 5. an accommodating mechanism; 51. connecting an internal threaded pipe; 52. a collection pipe; 53. a fixing hole; 54. a support disc; 55. aligning the clamping grooves; 56. holding a plate; 57. a clamping block; 58. a sampling cylinder; 6. a positioning device; 61. a chute; 62. a limiting slide bar; 63. a moving block; 64. a clamping block; 65. a guide block; 66. a connecting rod; 67. a drive ring; 68. a return spring.

Detailed Description

In order that the above objects, features and advantages of the present invention can be more clearly understood, a more particular description of the invention will be rendered by reference to the appended drawings.

In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention, however, the present invention may be practiced in other ways than those specifically described herein, and thus the present invention is not limited to the specific embodiments disclosed below.

The acute kidney injury early-stage prediction device shown in fig. 1-8 comprises a placing box 1, wherein an upper cover 2 is arranged at the upper end of the placing box 1 in a rotating mode, a supporting frame 3 is arranged at the bottom inside the placing box 1, an extracting mechanism 4 is clamped at the upper end of the supporting frame 3, a positioning device 6 is installed at the lower end of the extracting mechanism 4 in a threaded mode, and the positioning device 6 is fixedly installed at the upper end, close to the corner of the rear side of one side, of the placing box 1.

The extraction mechanism 4 comprises an extraction cylinder 41 movably clamped on the inner side of the upper end of the support frame 3, a piston is arranged inside the extraction cylinder 41 in a sliding mode, a piston push rod 42 is fixedly arranged at the rear end of the piston, a connecting pipe 43 is fixedly arranged at the front end of the extraction cylinder 41, the connecting pipe 43 is communicated with the extraction cylinder 41, a containing pipe 44 is arranged at the front end of the connecting pipe 43, the lower end of the containing pipe 44 is fixedly arranged close to the rear side, a liquid outlet 46 is arranged at the lower end of the containing pipe 44 close to the front side, the liquid outlet 46 is communicated with the containing pipe 44, a stopper 47 is arranged at the position, close to the bottom of the rear side, inside of the containing pipe 44, the stopper 47 is in a semicircular shape, and the outer circular surface of the stopper 47 is attached to the inner circular surface of the containing pipe 44.

When the urine collector is used, when urine is sampled, a user holds the handle 45 at the lower end of the extracting barrel 41 with one hand, a conduit at the front end of the accommodating pipe 44 is inserted into a specified urine collecting container, the piston push rod 42 is pulled to drive the piston at one end of the piston push rod 42 to move in the extracting barrel 41, so that the aim of extracting urine is fulfilled, the urine entering the inside of the accommodating pipe 44 is blocked by the stop block 47 and can be discharged into the collecting pipe 52 from the liquid outlet 46 for collection, the sampling mode of the extracting mechanism 4 is adopted, the sampling mode is firstly similar to that of an injector, the sampling is stable, in addition, the sampling is carried out by adopting an appliance in the whole sampling process, the hands are not in contact, the urine collector is sanitary, and cannot be polluted.

Hold mechanism 5 including the 21 of threaded connection at the lower extreme of liquid outlet 46, connect the fixed collecting pipe 52 that is provided with of lower extreme of internal thread pipe 51, be fixed intercommunication relation between collecting pipe 52 and the internal thread pipe 51 of being connected, six sets of fixed orificess 53 that are circular array and arrange are seted up on the upper end inclined plane of collecting pipe 52, hold mechanism 5 still including fixed the supporting disk 54 who sets up in the junction of connecting internal thread pipe 51 and collecting pipe 52, counterpoint draw-in groove 55 has been seted up to the upper end of supporting disk 54, counterpoint draw-in groove 55's inside is provided with fixture block 57, looks adaptation between fixture block 57 and counterpoint draw-in groove 55, fixture block 57 activity joint is in counterpoint draw-in groove 55's inside, fixture block 57's the fixed holding dish 56 that is provided with in the inside of holding dish 56, the inside of every group draw-in groove all is provided with a set of fixture block 57.

When thinning the sample, can realize six groups of urine of sample and store in reset spring 68's inside through using six groups of sampling barrels 58, can realize the purpose of disposable sample multiunit, need not the laboratory and divide the urine of sample again, it is more practical, in addition in order to insert six groups of sampling barrels 58 steadily in the inside of six groups of fixed orifices 53 of the upper end of collecting pipe 52 accurately, align the counterpoint draw-in groove 55 of seting up in the upper end of supporting disk 54 through the fixture block 57 of the lower extreme of holding disk 56, holding disk 56 can realize inserting six groups of sampling barrels 58 in fixed orifices 53 down in the vertical direction, fixture block 57 can also accurate joint in the inside of counterpoint draw-in groove 55 simultaneously, make the in-process device of sample more stable.

The positioning device 6 comprises a sliding groove 61 which is arranged at the upper end of the upper cover 2 and is close to the rear side position, a placing hole is formed in the upper end of the upper cover 2 and is close to the rear side corner, the number of the sliding grooves 61 is two, the two sliding grooves 61 are respectively located at the two side positions of the placing groove, two groups of fixedly connected limiting sliding rods 62 are arranged inside each placing groove, a moving block 63 is connected to the outer side of each limiting sliding rod 62 in a sliding mode, the moving block 63 is matched with the sliding groove 61 in a sliding mode, the moving block 63 is connected inside the sliding groove 61 in a sliding mode, a clamping block 64 is arranged at the upper end of the moving block 63, a guide block 65 is fixedly arranged at the upper end of the clamping block 64, a connecting rod 66 is fixedly connected to one end of the moving block 63, and a driving ring 67 is fixedly arranged at the upper end of the connecting rod 66.

At the moment, the collecting pipe 52 is rotated, so that the connecting internal thread pipe 51 is rotated from the outer side of the liquid outlet 46, at the moment, the two groups of driving rings 67 are hooked by fingers to pull towards the direction away from the connecting rod 66, the connecting rod 66 can move to drive the moving block 63 to slide on the outer side of the limiting slide rod 62, the return spring 68 on the outer side of the limiting slide rod 62 can be compressed to drive the clamping blocks 64 and the guide blocks 65 to move away from each other, so that the aim of opening the two groups of clamping blocks 64 is achieved, at the moment, the collecting pipe 52 filled with urine is inserted between the two groups of clamping blocks 64 through the guide effect of the guide blocks 65, the two groups of driving rings 67 are loosened, the compressed return spring 68 is reset under the self elastic force, so that the two groups of moving blocks 63 are driven to move towards the direction close to drive the clamping blocks 64 to clamp the collecting pipe 52 between the two groups of clamping blocks 64, the collecting pipe 52 is clamped and positioned in the mode, the mode is flexible, and the subsequent thinning sampling process can be more stable.

s1: firstly, urine is sampled primarily by the extraction mechanism 4, and the urine is sampled into the collection pipe 52 by the extraction mechanism 4 to be stored;

s2: then, the collecting pipe 52 is clamped in the positioning device 6 for fixing by opening the positioning device 6;

s3: finally, the urine in the interior of collection tube 52 can be subdivided and sorted by groups of sampling cartridges 58.

The working principle is as follows: when the urine collecting device is used for sampling urine, a user holds the handle 45 at the lower end of the extracting barrel 41 with one hand, a catheter at the front end of the accommodating pipe 44 is inserted into a specified urine collecting container, the piston push rod 42 is pulled to drive the piston at one end of the piston push rod 42 to move in the extracting barrel 41, so that the aim of extracting the urine is fulfilled, the urine entering the accommodating pipe 44 is blocked by the stop block 47 and is discharged into the collecting pipe 52 from the liquid outlet 46 for collection, the sampling mode of the extracting mechanism 4 is adopted, firstly, the sampling mode similar to a syringe is adopted, the sampling is stable, in addition, the sampling is carried out by adopting an appliance in the whole sampling process, the hands are not in contact, the urine is sanitary for individuals, the urine cannot be polluted, at the moment, the collecting pipe 52 is rotated, so that the connecting internal thread pipe 51 is rotated from the outer side of the liquid outlet 46, at the moment, the two groups of driving rings 67 are hooked by fingers and pulled towards the direction of keeping away, so that the purpose of driving the connecting rod 66 to move is achieved, the connecting rod 66 can move to drive the moving block 63 to slide on the outer side of the limiting slide rod 62, the return spring 68 on the outer side of the limiting slide rod 62 can be compressed, the purpose of driving the clamping blocks 64 and the guide blocks 65 to move away is achieved, so that the purpose of opening the two groups of clamping blocks 64 is achieved, at the moment, the collecting pipe 52 filled with urine is inserted between the two groups of clamping blocks 64 through the guiding effect of the guide blocks 65, the two groups of driving rings 67 are loosened, the compressed return spring 68 resets under the elastic force action of the self, so that the two groups of moving blocks 63 are driven to move towards the direction of getting close, the collecting pipe 52 is clamped between the two groups of clamping blocks 64, and the clamping and the collecting pipe 52 is clamped and positioned through the mode, the mode is more nimble, can be so that more stable at subsequent in-process that refines the sample, when refining the sample, can realize six groups of urine of sample and store in reset spring 68's inside through using six groups of sampling barrels 58, can realize the purpose of disposable sample multiunit, need not the laboratory and divide the urine of sample again, it is more practical, in addition in order to insert six groups of sampling barrels 58 steadily to the inside of six groups of fixed orifices 53 of the upper end of collecting pipe 52, through aiming at the counterpoint draw-in groove 55 of seting up in the upper end of supporting disk 54 with the fixture block 57 of the lower extreme of holding disk 56, vertical direction is down holding disk 56 can realize inserting six groups of sampling barrels 58 in the fixed orifices 53, fixture block 57 can also accurate joint in the inside of counterpoint draw-in groove 55 simultaneously, make the in-process device of sample more stable.

In the present invention, the terms "mounting", "connecting", "fixing" and the like are used in a broad sense, for example, "connecting" may be a fixed connection, a detachable connection, or an integral connection; may be connected with each other or indirectly connected with each other through an intermediate medium. The specific meanings of the above terms in the present invention can be understood by those skilled in the art according to specific situations.

In the description herein, the appearances of the phrases "one embodiment," "some embodiments," "a specific embodiment," or the like, in various places throughout this specification are not necessarily all referring to the same embodiment or example, but rather to the same embodiment or example. In this specification, the schematic representations of the terms used above do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.

The foregoing shows and describes the general principles, essential features, and advantages of the invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are merely illustrative of the principles of the invention, but various changes and modifications may be made without departing from the spirit and scope of the invention, which is defined by the appended claims. The scope of the invention is defined by the appended claims and equivalents thereof.

Claims

1. Acute kidney injury early prediction device, including placing box (1), its characterized in that, the upper end of placing box (1) is rotated and is provided with upper cover (2), the inside bottom of placing box (1) is provided with support frame (3), the upper end joint of support frame (3) has and draws mechanism (4), draw the lower extreme screw thread of mechanism (4) and install positioner (6), the upper end of placing box (1) is close to one side rear side corner fixed mounting and has positioner (6).

2. The acute kidney injury early-stage prediction device according to claim 1, characterized in that the extraction mechanism (4) comprises an extraction cylinder (41) movably clamped inside the upper end of the support frame (3), a piston is slidably arranged inside the extraction cylinder (41), a piston push rod (42) is fixedly arranged at the rear end of the piston, a connecting pipe (43) is fixedly arranged at the front end of the extraction cylinder (41), and the connecting pipe (43) is communicated with the extraction cylinder (41).

3. The early acute kidney injury prediction device according to claim 2, characterized in that the front end of the connection tube (43) is provided with a holding tube (44), the lower end of the holding tube (44) is fixedly arranged near the rear side, the lower end of the holding tube (44) is provided with a liquid outlet (46) near the front side, the liquid outlet (46) is communicated with the holding tube (44), the inside of the holding tube (44) is provided with a stopper (47) near the rear bottom, the stopper (47) is semicircular, and the outer circular surface of the stopper (47) and the inner circular surface of the holding tube (44) are attached to each other.

4. The acute kidney injury early-stage prediction device according to claim 3, characterized in that the accommodating mechanism (5) comprises a screw thread connected to the lower end (21) of the liquid outlet (46), the lower end of the connecting internal thread tube (51) is fixedly provided with a collecting tube (52), the collecting tube (52) and the connecting internal thread tube (51) are in fixed communication, and the inclined surface of the upper end of the collecting tube (52) is provided with six groups of fixing holes (53) arranged in a circular array.

5. The acute kidney injury early prediction device according to claim 4, wherein the accommodating mechanism (5) further comprises a supporting disk (54) fixedly arranged at a joint of the connecting internal threaded tube (51) and the collecting tube (52), an alignment clamping groove (55) is formed in the upper end of the supporting disk (54), a clamping block (57) is arranged inside the alignment clamping groove (55), the clamping block (57) is matched with the alignment clamping groove (55), the clamping block (57) is movably clamped inside the alignment clamping groove (55), a holding disk (56) is fixedly arranged at the upper end of the clamping block (57), six groups of clamping grooves arranged in a circular array are arranged inside the holding disk (56), and a group of clamping blocks (57) is arranged inside each group of clamping grooves.

6. The acute kidney injury early prediction device according to claim 1, characterized in that the positioning device (6) comprises two sets of sliding grooves (61) disposed at the upper end of the upper cover (2) near the rear position, the upper end of the upper cover (2) near the rear corner is opened with a placement hole, the number of the sliding grooves (61) is two, the two sets of sliding grooves (61) are respectively disposed at the two side positions of the placement groove, and two sets of fixedly connected limiting sliding rods (62) are disposed inside each set of the placement groove.

7. The early acute kidney injury prediction device according to claim 6, characterized in that a moving block (63) is connected to the outer side of the limit slide bar (62) in a sliding manner, the moving block (63) is matched with the slide groove (61), and the moving block (63) is connected to the inside of the slide groove (61) in a sliding manner.

8. The acute kidney injury early prediction device according to claim 7, characterized in that a clamping block (64) is provided at an upper end of the moving block (63), and a guide block (65) is fixedly provided at an upper end of the clamping block (64).

9. The acute kidney injury early prediction device according to claim 8, characterized in that a connecting rod (66) is fixedly connected to one end of the moving block (63), and a driving ring (67) is fixedly arranged at the upper end of the connecting rod (66).

10. An acute renal injury early prediction method for operating the acute renal injury early prediction device according to any one of claims 1 to 9, comprising the steps of:

s1: firstly, urine is sampled primarily by the extraction mechanism (4), and the urine is sampled into the collection pipe (52) by the extraction mechanism (4) for storage;

s2: secondly, the collecting pipe (52) is clamped in the positioning device (6) for fixing by opening the positioning device (6);

s3: finally, urine in the interior of collection tube (52) can be subdivided and dispensed by multiple groups of sampling cartridges (58).