CN114767718A - 突变型博德特氏菌属菌株及其使用方法 - Google Patents

突变型博德特氏菌属菌株及其使用方法 Download PDF

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Publication number
CN114767718A
CN114767718A CN202210315642.5A CN202210315642A CN114767718A CN 114767718 A CN114767718 A CN 114767718A CN 202210315642 A CN202210315642 A CN 202210315642A CN 114767718 A CN114767718 A CN 114767718A
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pertussis
composition
deficient
prn
bordetella
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Pending
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CN202210315642.5A
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Chinese (zh)
Inventor
路易斯·索兰斯
卡米尔·洛赫特
安妮·蒂斯科普洛斯
萨利哈·艾特雅希亚森迪德
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Institut Pasteur de Lille
Institut National de la Sante et de la Recherche Medicale INSERM
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Institut Pasteur de Lille
Institut National de la Sante et de la Recherche Medicale INSERM
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Publication of CN114767718A publication Critical patent/CN114767718A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/42—Respiratory system, e.g. lungs, bronchi or lung cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/099—Bordetella
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/235—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bordetella (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/36—Adaptation or attenuation of cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K2039/10—Brucella; Bordetella, e.g. Bordetella pertussis; Not used, see subgroups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/543—Mucosal route intranasal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Rheumatology (AREA)
  • Wood Science & Technology (AREA)
  • Pain & Pain Management (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Physiology (AREA)
  • Communicable Diseases (AREA)
  • General Engineering & Computer Science (AREA)
  • Developmental Biology & Embryology (AREA)
CN202210315642.5A 2016-03-29 2017-03-29 突变型博德特氏菌属菌株及其使用方法 Pending CN114767718A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662314843P 2016-03-29 2016-03-29
US62/314,843 2016-03-29
PCT/EP2017/057468 WO2017167834A1 (en) 2016-03-29 2017-03-29 Mutant bordetella strains and methods for use
CN201780021384.7A CN109069535B (zh) 2016-03-29 2017-03-29 突变型博德特氏菌属菌株及其使用方法

Related Parent Applications (1)

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CN114767718A true CN114767718A (zh) 2022-07-22

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CN201780021384.7A Active CN109069535B (zh) 2016-03-29 2017-03-29 突变型博德特氏菌属菌株及其使用方法

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US (4) US10682377B2 (https=)
EP (2) EP4541809A3 (https=)
JP (1) JP6993984B2 (https=)
CN (2) CN114767718A (https=)
AU (2) AU2017242541B2 (https=)
DK (1) DK3436034T3 (https=)
ES (1) ES3027194T3 (https=)
FI (1) FI3436034T3 (https=)
SG (1) SG11201807783UA (https=)
WO (1) WO2017167834A1 (https=)

Families Citing this family (8)

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Publication number Priority date Publication date Assignee Title
US9119804B2 (en) 2006-03-10 2015-09-01 Institut Pasteur De Lille Live attenuated bordetella strains as a single dose vaccine against whooping cough
SG175803A1 (en) 2009-04-28 2011-12-29 Pasteur Institut Vaccine for prophylaxis or treatment of an allergen-driven airway pathology
EP4541809A3 (en) * 2016-03-29 2025-06-25 Institut Pasteur de Lille Mutant bordetella strains and methods of use
SG11202003333WA (en) 2017-10-18 2020-05-28 Pasteur Institut Bordetella strains expressing serotype 3 fimbriae
AU2021325149A1 (en) 2020-08-14 2023-03-02 ILiAD Biotechnologies, Inc. Lyophilized live bordetella vaccines
EP4247397A4 (en) * 2020-11-17 2024-11-06 Iliad Biotechnologies, LLC TREATMENT AND PREVENTION OF NEUROPATHOLOGY ASSOCIATED WITH NEURODEGENERATIVE DISEASES
CA3261556A1 (en) 2022-07-22 2024-01-25 Institut National de la Santé et de la Recherche Médicale USE OF BORDETELLA STRAINS FOR THE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
WO2025257397A1 (en) 2024-06-14 2025-12-18 Institut National de la Santé et de la Recherche Médicale Live attenuated bordetella vaccines capable of producing and secreting heterologous antigens

Citations (6)

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CN1147259A (zh) * 1994-04-28 1997-04-09 武田药品工业株式会社 分离百日咳杆菌保护性组分的方法
US6660261B1 (en) * 1996-10-11 2003-12-09 Institut Pasteur De Lille Bordetella strain expressing the FHA hybrid, liposomes and vaccines
CN101400783A (zh) * 2006-03-10 2009-04-01 巴斯德研究院里尔分院 包特氏菌减毒活菌株作为抗百日咳的单剂量疫苗
WO2010125014A1 (en) * 2009-04-28 2010-11-04 INSERM (Institut National de la Santé et de la Recherche Médicale) Vaccine for prophylaxis or treatment of an allergen-driven airway pathology
CN102793915A (zh) * 2012-07-25 2012-11-28 天津康希诺生物技术有限公司 一种无细胞百日咳疫苗的生产方法
WO2013066272A1 (en) * 2011-11-02 2013-05-10 National University Of Singapore Effect of an attenuated bordetella strain against allergic disease

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US6713072B1 (en) 1987-11-02 2004-03-30 Chiron S.R.L. Immunologically active polypeptides with altered toxicity useful for the preparation of an antipertussis vaccine
GB9115332D0 (en) * 1991-07-16 1991-08-28 Connaught Lab Manipulation of gene copy number in bordetella
FR2718750B1 (fr) 1994-04-19 1996-06-14 Pasteur Institut Protéines recombinantes de l'hémagglutinine filamenteuse de Bordetella, notamment, B. Pertussis, production et application à la production de protéines étrangères ou de principes actifs vaccinants.
FR2840319B1 (fr) 2002-05-30 2004-08-20 Pasteur Institut Souches de bordetella rendues deficientes par attenuation genetique
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US6660261B1 (en) * 1996-10-11 2003-12-09 Institut Pasteur De Lille Bordetella strain expressing the FHA hybrid, liposomes and vaccines
CN101400783A (zh) * 2006-03-10 2009-04-01 巴斯德研究院里尔分院 包特氏菌减毒活菌株作为抗百日咳的单剂量疫苗
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WO2013066272A1 (en) * 2011-11-02 2013-05-10 National University Of Singapore Effect of an attenuated bordetella strain against allergic disease
CN102793915A (zh) * 2012-07-25 2012-11-28 天津康希诺生物技术有限公司 一种无细胞百日咳疫苗的生产方法

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CA3018126A1 (en) 2017-10-05
JP2019513722A (ja) 2019-05-30
US20170283890A1 (en) 2017-10-05
DK3436034T3 (da) 2025-05-12
AU2022221438A1 (en) 2022-10-06
EP4541809A3 (en) 2025-06-25
US20230381224A1 (en) 2023-11-30
AU2017242541A1 (en) 2018-10-11
US20210290667A1 (en) 2021-09-23
FI3436034T3 (fi) 2025-05-08
EP3436034A1 (en) 2019-02-06
WO2017167834A1 (en) 2017-10-05
US10682377B2 (en) 2020-06-16
ES3027194T3 (en) 2025-06-13
AU2022221438B2 (en) 2024-10-03
AU2017242541B2 (en) 2022-06-30
US11065276B2 (en) 2021-07-20
CN109069535B (zh) 2022-03-18
CN109069535A (zh) 2018-12-21
EP4541809A2 (en) 2025-04-23
JP6993984B2 (ja) 2022-02-03
EP3436034B1 (en) 2025-03-26
SG11201807783UA (en) 2018-10-30
US20200323901A1 (en) 2020-10-15

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