CN114746757A

CN114746757A - Method and system for acquiring smear label information and cell image analyzer

Info

Publication number: CN114746757A
Application number: CN201980102716.3A
Authority: CN
Inventors: 姜斌; 邓文华; 艾露
Original assignee: Shenzhen Mindray Bio Medical Electronics Co Ltd
Current assignee: Shenzhen Mindray Bio Medical Electronics Co Ltd
Priority date: 2019-12-18
Filing date: 2019-12-18
Publication date: 2022-07-12
Also published as: WO2021120070A1

Abstract

A method of obtaining smear label information. The smear (100) comprises a first surface (110) and a second surface (120) which extend along the length direction of the smear and are opposite to each other, and a label section which carries label information (130), the first surface (110) or the second surface (120) of the smear (100) carries the label information (130), the smear (100) is placed to a recognition position by a smear clamping device (240), the first surface (110) of the smear (100) is recognized by a recognition device (210), if the recognition device (210) recognizes the label information (130) from the first surface (110), storing the label information (130) of the smear, if the identification means (210) does not identify the label information (130) from the first side (110), the recognition device (210) recognizes the second surface (120), and when the recognition device (210) recognizes the label information (130) from the second surface (120), the label information (130) of the smear is stored. By identifying both sides of the smear (100), the label information (130) of the smear (100) can be ensured to be identified, and the smear (100) can be ensured to be placed on a detection workbench to be detected in a posture that the surface where the label information (130) is located faces the correct direction. The method also relates to a smear recognition system, a cytological image analyzer and a computer-readable storage medium.

Description

Method and system for acquiring smear label information and cell image analyzer

Technical Field

The invention relates to the field of medical instruments, in particular to a method for acquiring smear label information and a method for automatically detecting the smear placement state. The invention also relates to a smear recognition system, a cytological image analyser comprising such a smear recognition system and a computer-readable storage medium.

Background

When a current cytomorphological analyzer (also called as a cytographic analyzer or a digital microscope) detects a sample smear prepared from a sample such as blood, peripheral blood, a disease protozoan, bone marrow, or body fluid, the working distance of an objective lens with high magnification is smaller, especially about 0.2mm for a 100-fold oil lens, in a microscopic imaging process. That is, when the 100-fold objective lens is operated, the lower end surface thereof is spaced apart from the slide to be tested by only about 0.2mm, and is almost in a close contact state, whereas a standard slide has a thickness of about 0.9mm to 1.1 mm. Therefore, the sample smear side surface must be placed toward the lens to ensure that the sample is spaced from the objective lens effectively, otherwise clear imaging is not possible.

For an automatic cytomorphological analyzer, if the sample smear is placed wrongly, namely, the side surface of the sample smear, which is not coated with the sample, faces to the objective lens, the lens may be pressed against the sample smear during the automatic focusing process of the cytomorphological analyzer, so that the sample smear and even the lens are damaged.

Therefore, the user needs to place the smear coated with the sample in a strictly specified manner, which may otherwise cause the cytomorphological analyzer to not work normally and not complete the scanning or shooting function of the pathological smear as expected. In extreme cases, damage to the core optical components of the cellular morphology analyzer (e.g., the microscope objective) can also result.

Disclosure of Invention

The embodiment of the invention provides a method for acquiring smear label information, a method for automatically detecting the smear placement state through the label information, a smear identification system for acquiring the smear label information, a cell image analyzer with the smear identification system and a computer-readable storage medium. By the embodiment of the invention, the labels on two sides or two ends of the smear are identified, so that the identification information of the smear can be ensured, and the placement state of the smear can be further identified, and the smear can be further ensured to be subsequently placed on the detection workbench to be detected in a posture that the side or the end part where the label information is located faces the correct direction.

The present invention provides in a first aspect a method of obtaining information from a smear comprising opposed first and second faces extending lengthwise thereof and including a label section for carrying label information, the first or second face of the smear carrying the label information thereon, the method comprising:

controlling a smear clamping device to place the smear to a recognition position, so that a first side of the smear is in a recognition range of a recognition device;

controlling the identification device to identify the label information of the first surface of the smear;

if the identification device identifies the label information of the smear from the first side of the smear, storing the label information of the smear;

if the identification device does not identify the label information of the smear from the first side of the smear, controlling the identification device to identify the label information of the second side of the smear;

and if the identification device identifies the label information of the smear from the second side of the smear, storing the label information of the smear.

The present invention provides in a second aspect a method of obtaining smear label information, the smear comprising along its length opposed first and second ends and a label section for carrying label information, the smear being provided with the label section at either the first or second end, the method comprising:

controlling a smear clamping device to place a smear to a recognition position so that a first end of the smear is within a recognition range of a recognition device;

controlling the identification device to identify the label information of the first end of the smear;

if the identification device identifies the label information of the smear from the first end of the smear, storing the label information of the smear;

if the identification device does not identify the label information of the smear from the first end of the smear, controlling the identification device to identify the label information of the second end of the smear;

and if the identification device identifies the label information of the smear from the second end of the smear, storing the label information of the smear.

The third aspect of the invention provides a method for automatically detecting the smear placing state, which comprises the following steps:

the smear clamping device clamps a smear to the identification position, and the smear comprises a label section capable of bearing label information;

the identification device identifies the label information of the smear;

and acquiring the placing state of the smear on the identification position according to the identification condition of the identification device on the label information of the smear.

The embodiment of the invention utilizes the characteristics that the front surface of the smear simultaneously bears the label information and is smeared with the sample, and utilizes the identification device to identify the label information of the smear to judge the placement state of the smear at the identification position. Specifically through placing the smear to the discernment position after, according to recognition device is right the state of placing of smear on the discernment position is obtained to the identity information discernment condition of smear, and then can ensure that follow-up smear is placed the workstation of cell image analysis appearance with predetermined gesture and is detected.

The present invention provides in a fourth aspect a smear recognition system for obtaining smear label information, the smear comprising opposed first and second faces extending along its length and including a label section for carrying label information, the smear having the label information carried on either the first or second face, the smear recognition system comprising:

the smear clamping device is used for clamping the smear to the identification position;

the identification device is used for identifying the label information of the smear on the identification position;

a control device electrically connected with the smear gripping device and the recognition device, and configured to:

controlling the smear gripping device to place the smear to a recognition position so that a first side of the smear is within a recognition range of a recognition device;

if the identification device identifies the smear label information from the first side of the smear, storing the smear label information;

The fifth aspect of the present invention provides a cellular image analyzer comprising:

the digital imaging device comprises a lens group and a digital camera and is used for shooting the image of the cells on the smear;

the smear moving device is provided with a detection workbench and is used for adjusting the relative position of the digital imaging device and the smear;

and a smear identification system provided in a fourth aspect of the invention.

The fifth aspect of the present invention also provides a computer-readable storage medium storing executable instructions configured to cause a processor to perform the method according to the first, second and third aspects of the present invention.

By the aid of the method and the device, risks of poor detection effect, damage of the smear or a lens and the like caused by mistaken placement of the smear by a user in a process of detecting the smear by using the cell analyzer can be reduced or even avoided, and orderly work of the cell analyzer is guaranteed.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the drawings without creative efforts.

FIG. 1 is a side view of a smear according to an embodiment of the present invention;

FIG. 2 is a schematic illustration of a smear and tag information according to an embodiment of the present invention;

FIG. 3 is a schematic diagram of a frame of a smear recognition system provided by an embodiment of the present invention;

FIG. 4 is a schematic diagram of a framework of a control device provided by an embodiment of the invention;

FIG. 5 is a flowchart of a method for acquiring smear label information according to an embodiment of the present invention;

FIG. 6 is a schematic view of a working scene of the smear recognition system provided by the embodiment of the invention;

FIGS. 7 and 8 are schematic diagrams illustrating different scenarios of a method for acquiring smear label information according to an embodiment of the present invention;

fig. 9 and 10 are perspective views of a rotating device provided in an embodiment of the present invention;

FIG. 11 is a schematic view of another scene of a method for acquiring smear label information according to an embodiment of the present invention;

FIG. 12 is another flowchart of a method for obtaining smear label information according to an embodiment of the present invention;

FIGS. 13 to 15 are schematic views of different working scenarios of the smear being placed on the inspection bench according to the embodiment of the present invention;

FIGS. 16a-16d are schematic views of a smear gripping apparatus provided in an embodiment of the present invention;

FIG. 17 is another flowchart of a method for obtaining smear label information according to an embodiment of the present invention;

FIG. 18 is a schematic view of another embodiment of a method for acquiring smear label information according to the present invention;

FIG. 19 is another flowchart of a method for obtaining smear label information according to an embodiment of the present invention;

FIGS. 20 and 21 are schematic views of different working scenarios of smear placement on the inspection bench provided by the embodiment of the present invention;

FIGS. 22 to 26 are different flowcharts of the method for automatically detecting the smear placement status according to the embodiment of the present invention;

FIG. 27 is a schematic block diagram of a cellular image analyzer according to an embodiment of the present invention;

FIG. 28 is a perspective view of a cell image analyzer according to an embodiment of the present invention.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

The numbering of the components as such, e.g., "first", "second", etc., is used herein only to distinguish the objects as described, and does not have any sequential or technical meaning. The term "connected" and "coupled" as used herein includes both direct and indirect connections (couplings), unless otherwise specified. In the description of the present invention, it is to be understood that the terms "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", and the like, indicate orientations or positional relationships based on those shown in the drawings, and are only for convenience of description and simplicity of description, but do not indicate or imply that the referenced devices or elements must have a particular orientation, be constructed and operated in a particular orientation, and thus, are not to be construed as limiting the present invention.

The embodiment of the invention provides a method for acquiring the label information of a smear 100, which can be applied to a cell image analyzer. The sample 140 includes, but is not limited to, blood, peripheral blood, protozoa, bone marrow or body fluids, etc. A cytological image analysis apparatus generally comprises an imaging device, a smear moving device and an image analysis device. The imaging device comprises a lens group and a camera and is used for shooting the image of the cells in the sample smeared on the smear. The smear moving device is used for carrying the smear and adjusting the relative position of the smear and the imaging device, so that the imaging device can shoot a cell image of a specific area of the smear. The image analysis device is used for analyzing the image of the cells in the sample smeared on the coating. The cell image analyzer will be described in detail below.

See smear 100 shown in FIG. 1. The smear 100 includes opposing first and

second sides

110, 120 extending lengthwise. The smear 100 also includes first and second ends 101 and 102 opposite in the direction of lengthwise extension. The first side 110 or the second side 120 of the smear 100 is also provided with the label information 130 and the sample 140 coated thereon, i.e., during preparation of the smear 100, the label information 130 of the smear 100 is typically provided on the side of the smear 100 coated with the sample 140. The smear 100 includes a label section for carrying label information 130. The label information 130 is carried on the first side 110 or the second side 120 of the label section. In the embodiment shown in FIG. 1, the first side 110 of the smear 100 is provided with label information 130 and is coated with a sample 140. In other embodiments, the label information 130 of the smear 100 and the sample 140 can also be provided on the second side 120 simultaneously.

Referring to fig. 2, fig. 2(a) shows an overall schematic view of the smear 100, and fig. 2(b) - (c) show different forms of tag information. The label information is provided on a label section of the smear 100 that is provided on either the first end 101 or the second end 102 of the smear 100, such as on the first end 101 of the smear 100 in fig. 2 (a). The tag information includes smear identity information. The identity information may be carried on the label section in the form of a two-dimensional code, a one-dimensional barcode, printed text, handwritten text, or the like. In addition, the label information may also include other printed text information, special indicia, product logo, color or handwritten indicia, and the like.

Fig. 3 illustrates a smear recognition system 200 provided by an embodiment of the present invention. The smear recognition system 200 includes a recognition device 210, a control device 220, and a smear gripping device 240. The smear gripping device 240 is used to grip the smear 100 onto the recognition site 01. The recognition means 210 is used to recognize the tag information of the smear 100 located on the recognition site 01. The control device 220 is electrically connected to the recognition device 210 and the smear gripping device 240, and is configured to control the actions of the recognition device 210 and the smear gripping device 240 and acquire the label information of the smear 100, that is, configured to implement the following steps of the method provided by the embodiment of the present invention.

In an embodiment of the present invention, the Controller 220 may be implemented in one or more Application Specific Integrated Circuits (ASICs), DSPs, Programmable Logic Devices (PLDs), Complex Programmable Logic Devices (CPLDs), Field Programmable Gate Arrays (FPGAs), general purpose processors (gpus), controllers, Micro Controllers (MCUs), microprocessors (microprocessors), or other electronic components.

In an embodiment of the present invention, as shown in fig. 4, the control device 220 at least includes: processing component 221, RAM222, ROM223, communication interface 224, memory 226, and I/O interface 225, where processing component 221, RAM222, ROM223, communication interface 224, memory 226, and I/O interface 225 communicate over bus 227.

The processing component may be a CPU, GPU or other chip with computing capabilities.

The memory 226 stores various computer programs such as an operating system and an application program to be executed by the processor unit 221, and data necessary for executing the computer programs. In addition, data stored locally during the smear identification process, if desired, may be stored in the memory 226.

The I/O interface 225 is constituted by a serial interface such as USB, IEEE1394, or RS-232C, a parallel interface such as SCSI, IDE, or IEEE1284, and an analog signal interface composed of a D/a converter, an a/D converter, and the like. An input device, such as a keyboard, mouse, touch screen, or other control buttons, is connected to the I/O interface 225, and a user can input data directly to the control device 240 using the input device. In addition, a display having a display function, such as: liquid crystal screen, touch screen, LED display screen, etc., the control device 220 may output the processed data to the display as image display data for displaying, for example: analytical data, instrument operating parameters, etc.

Communication interface 224 is an interface that may be any communication protocol currently known. The communication interface 224 communicates with the outside world through a network. Control device 220 may communicate data with any device connected via the network via communication interface 224 using a communications protocol.

FIG. 5 shows a method for acquiring smear label information, which includes:

s10, controlling the smear gripping device 240 to place the smear 100 to the recognition position 01, so that the first side 110 of the smear 100 is in the recognition range of the recognition device 210;

s20, controlling the recognition device 210 to recognize the label information of the first side 110 of the smear 100;

s30, if the identification device 210 identifies the label information 130 of the smear 100 from the first side 110 of the smear 100, storing the label information 130 of the smear 100;

s40, if the identification device 210 does not identify the label information 130 of the smear 100 from the first side 110 of the smear 100, controlling the identification device 210 to identify the label information of the second side 120 of the smear 100;

s50, if the identification device 210 identifies the label information 130 of the smear 100 from the second side 120 of the smear 100, the label information of the smear 100 is stored.

In the embodiment shown in fig. 6, the smear 100 is placed to the recognition site 01 by controlling the smear gripping device 240 so that the first side 110 of the smear 100 is within the recognition range of the recognition device 210. The identification device 210 is then turned on to first identify the first side 110 of the smear 100 to obtain the labeling information of the smear 100. When the identification means 210 has obtained the smear 100 label information from the first side 110 of the smear 100, the smear 100 label information is stored accordingly. But the label information of the smear 100 may also be located on the second side 120 of the smear 100. When the identification device 210 does not acquire the label information of the smear 100 from the first side 110 of the smear 100, the relative position of the identification device 210 and the smear 100 at the identification position 01 can be adjusted, the identification device 210 is controlled to identify the second side 120 of the smear 100, and after the label information is identified on the second side 120 of the smear 100, the label information of the smear 100 is correspondingly stored. The tag information of the smear 100 is stored, for example, in the memory 226 of the control device 220.

In the prior art, only one outer surface of the smear 100 is identified with the label information. If the initial placement of the smear 100 results in the recognition device 210 not being able to recognize the label information from the outer surface of the smear 100, subsequent testing of the smear may be stopped or a temporary identity information assigned to the smear. Without stopping the subsequent testing of the smear, it may result in the smear 100 being subsequently placed in the wrong position on the test station. The embodiment of the invention improves the identification efficiency of the smear 100 on the label information, especially the identity information, by identifying the label information on the first side 110 and the second side 120 of the smear 100, and avoids unnecessarily stopping subsequent detection. In addition, because the label information of the smear 100 and the sample are usually located on the same side of the smear 100, the surface on which the sample is located can be determined by identifying the surface on which the label information is located, and it can be further ensured that the smear 100 is subsequently placed on the detection workbench in a correct posture.

It should be noted that the first side 110 and the second side 120 of the smear 100 are not strictly distinguished during actual use, and are only used for distinguishing the described objects, and do not have any order or technical meaning. For example, the first side 110 and the second side 120 of the smear 100 may be defined relative to the state in which the smear 100 is placed in the recognition bit 01. In an embodiment of the present application, the first side 110 may be defined as one of the opposite sides of the smear 100 initially placed in the recognition site 01 extending in the length direction 001 within the recognition area of the recognition device 210. The embodiment of the application firstly controls the identification device 210 to identify the label information on the first side 110 of the smear 100. Since it is also possible that both the smear's label information and the sample are located on the second side 120, the identification device 210 is unable to identify the smear's label information from the first side 110 of the smear 100. Thus, by adjusting the relative position between the smear 100 and the recognition device 210 such that the second side 120 of the smear 100 is within the recognition area of the recognition device 210, the recognition device 210 can perform tag information recognition on the second side 120 of the smear 100.

In one embodiment, the recognition device 210 may include a camera for recognizing tag information in the form of text, images, special marks, and the like. The first side 110 or the second side 120 of the smear 100 is photographed by a camera, and then the characteristics of the image are recognized, so that the effective label information is extracted from the image and is stored and recorded as the label information of the slide 100. Accordingly, the above steps S20 and S40 may include: the camera is controlled to take a picture of the first side 110 or the second side 120 of the smear 100 to perform feature recognition on the picture taken by the camera and to extract the tag information of the smear.

In another embodiment, the label section of the smear 100 may be printed with a barcode (e.g., a one-dimensional barcode or a two-dimensional code) to carry label information. The identification device 210 may now include a barcode scanner by which the first side 110 or the second side 120 of the smear 100 is barcode scanned for label information. Compared with a camera, the bar code scanner is adopted as the identification device, so that the cost can be reduced. Accordingly, the above steps S20 and S40 include: the bar code scanner is controlled to perform bar code scanning on the first side 110 or the second side 120 of the smear 100 to extract the label information of the smear 100.

It is understood that, in order to ensure the accuracy of the identification of the tag information, the identification device 210 may further include a camera and a bar code scanner to identify the tag information at the same time, so as to improve the identification accuracy of the tag information. Accordingly, steps S20 and S40 may include: controlling the camera to take a picture of the first side 110 or the second side 120 of the smear 100 so as to perform feature recognition on the picture acquired by the camera and extract label information of the smear 100; and controlling the barcode scanner to perform barcode scanning on the first side 110 or the second side 120 of the smear 100 to extract the label information of the smear 100.

In an embodiment of the present invention, the steps S20 and S40 may include:

the bar code scanner is controlled to perform bar code scanning on the first side 110 or the second side 120 of the smear 100 to extract the label information of the smear 100.

And if the bar code scanner does not extract the label information of the smear, controlling the camera to photograph the first side 110 or the second side 120 of the smear 100 so as to perform feature recognition on the photograph acquired by the camera and extract the label information of the smear 100.

As shown in fig. 7, in an embodiment of the invention, before step S40, the method further comprises adjusting the relative position between the recognition device 210 and the smear 100 located at the recognition site 01, for example, controlling the recognition device 210 to rotate around the recognition site 01 so that the second side 120 of the smear 100 is within the recognition range of the recognition device 210.

As shown in fig. 8, the recognition means 210 comprises a first recognition member 2101 and a second recognition member 2102 arranged symmetrically with respect to the recognition bit 01 of the smear 100. Accordingly, step S20 includes: the first recognition component 2101 is controlled to perform the identification of the label information on the first side 110 of the smear 100. Step S40 includes: the second recognition mechanism 2102 is controlled to perform the tag information recognition of the second side 120 of the smear 100. The first 2101 and second 2102 recognition means may simultaneously or sequentially recognize the first side 110 and the second side 120 of the smear 100 under the control of the control means 220.

In one embodiment of the invention, the smear 100 is driven to turn over relative to the recognition device 210 on the recognition position 01, so that the recognition device 210 recognizes the first side 110 and the second side 120 in sequence. Specifically, the smear 100 includes at least two poses on the recognition site 01. When the smear 100 is in a first state, the first side 110 of the smear 100 is within the identification area of the identification device 210. When the smear 100 is in the second state, the second side 120 of the smear 100 is within the identification area of the identification device 210. Preferably, the first side 110 of the applicator 100 faces the identification device 210 when in the first state. And when the coating sheet 100 is in the second state, the second side 120 thereof also faces the identification device 210. Thus, in adjusting the smear 100 from the first state to the second state, the smear 100 needs to be flipped 180 ° around its length. It will be appreciated that in some embodiments, the smear 100 may be rotated at other angles when switching between the first and second states.

In one embodiment, as shown in FIGS. 9 and 10, the smear recognition system 200 further includes a rotation device 230 capable of receiving the smear 100. The rotating device 230 is designed to be rotatable about its central axis 232 in order to be able to rotate the received smear 100, in particular the received smear 100, about its central axis. Accordingly, the step S10 includes: the smear gripping device 240 is controlled to place the smear 100 into the rotating device 230 so that the first side 110 of the smear 100 is within the recognition area of the recognition device 210. Accordingly, prior to step S40, the method includes: the rotating device 230 is controlled to drive the smear 100 contained therein to rotate, so that the second side 120 of the smear 100 is within the identification range of the identification device 210.

In one embodiment, the smear gripping device 240 moves to a specific position in a horizontal direction to grip the smear 100, then moves to above the rotating device 230 in a horizontal direction to grip the smear, and then places the smear on the rotating device 230. In some embodiments, it can be set that after the smear gripper device 240 places the smear 100 onto the rotating device 230, the first side of the smear 100 is within the identification area of the identification device 210. However, it may be set that after the smear gripper device 240 places the smear 100 on the rotating device 230, both sides of the smear 100 are not within the recognition area of the recognition device 210, but the first side of the smear 100 is within the recognition area of the recognition device 210 by the rotation of the rotating device 230.

For example, after the smear gripper device 240 places the smear into the rotator device 230, the rotator device 230 is rotated 90 ° in the direction of Z1 so that the first side of the smear 100 is within the recognition area of the recognition device 210. The identification means 210 reads the label information on the first side of the smear 100 and if the reading is normal, the rotating means 230 returns to the initial position and the smear gripper means 240 takes the smear 100 away again. If the smear 100 cannot be read, the rotating device 230 needs to rotate 180 degrees in the direction of Z1 again, and after the identification device 210 reads the information of the label on the second side of the smear 100, the rotating device 230 needs to rotate 90 degrees in the direction of Z1, and the smear gripper 240 takes the smear 100 again. After the smear 100 is removed, the rotating device 230 returns to the initial position.

Fig. 9 is a schematic structural view of the rotating device 230, and the rotating device 230 includes an accommodating groove 231 with an open top. The receiving groove 231 is used for receiving the smear 100. The containing groove 231 extends along the axis 232 of the rotating device 230, and the top of the containing groove 231 is provided with an opening 233, and the smear 100 is disposed into the containing groove 231 from the opening 233. Referring to fig. 10, the rotation device 230 may be disposed corresponding to the identification bit 01, that is, the identification bit 01 is disposed on the rotation device 230. When the smear 100 is received on the rotating device 230, the rotating device 230 is used to position the smear 100 such that the first side 110 or the second side 120 thereof is within the identification area of the identification device 210, so that the identification device 210 performs the identification of the smear with the tag information. The smear 100 contained in the container 231 needs to be exposed at least for a length at least greater than the length of the label section of the smear 100. Because the containing groove 231 extends along the axis 232, when the smear 100 is contained in the containing groove 231, the smear 100 is also parallel to the axis 232. When the rotating device 230 rotates around the axis 232, the contained smear 100 can be driven to rotate around the axis 232, so that the smear can be overturned under the drive of the rotating device 230.

The rotating device 230 can also be electrically connected with the control device 220, and the control device 220 is used for controlling the rotating device 230 to rotate, so that the smear 100 in the rotating device 230 can be switched between the first state and the second state. The provision of the rotation means 230 facilitates a compact design of the overall structure of the cellular image analyzer, compared to an embodiment in which the recognition means 210 is rotated relative to the recognition site.

In an embodiment of the invention the rotating means 230 is configured to be rotatable at least 180 degrees in a predetermined direction of rotation in order to be able to bring the received smear 100 to rotate at least 180 degrees in the predetermined direction of rotation around an axis extending in the length direction of the smear 100, in particular around the central axis of the smear 100, so that the smear 100 is switched between the first state and the second state on the identification location 01. At this time, the recognition device 210 is preferably set to be stationary.

It will be understood that the rotating means 230 may also be configured to rotate the received smear 100 less than 180 degrees around an axis extending along the length of the smear 100, in particular around the central axis of the smear 100, as long as the rotating means 230 is capable of switching the received smear 100 between the first state and the second state, which is considered to be within the scope of the present application.

Further, the rotating device 230 may be configured to rotate at least 360 degrees in a predetermined rotational direction, such as multiple rotations about its central axis in at least one rotational direction, to rotate the contained smear 100. The rotating device 230 can only rotate at least 360 degrees along one rotation direction at this time, so that the smear 100 is switched between the first state and the second state on the identification position 01, and the embodiment can simplify the control mode of the rotating mechanism.

As shown in fig. 9, the top opening of the rotating means 230 has a guide portion for guiding the smear 100 picked up by the smear gripping mechanism 240 into the receiving groove 231. The rotating device 230 has a gap in the middle to facilitate cleaning of the broken smear 100.

In an embodiment of the present invention, before the step S40, the method includes: the smear gripping device 240 is controlled to adjust the smear 100 from the first state to the second state so that the second side of the smear 100 is within the recognition range of the recognition device 210.

Referring to fig. 11, the smear gripping device 240 is configured to be rotatable. Because the smear gripping device 240 can rotate around its own axis, when the smear gripping device 240 grips the smear 100, its rotation can drive the smear 100 gripped by it to rotate therewith, so that the smear 100 is switched between the first state and the second state on the recognition position 01.

It can be understood that the smear gripping device 240 can also be configured to rotate at least 180 degrees around its own axis to drive the gripped smear 100 to rotate, so that the smear 100 can be switched between the first state and the second state on the recognition site 01. The first side 110 and the second side 120 of the smear 100 can be directly identified to the identification device 210 by rotating 180 degrees. Of course, the smear gripping device 240 may be configured to rotate less than 180 degrees around its axis, and the smear gripping device 240 may be regarded as the scope of the present application as long as it can switch the gripped smear 100 between the first state and the second state. The smear gripping device 240 may also be configured to rotate 360 degrees around its axis so that the smear 100 is switched between the first state and the second state at the recognition site 01, which can simplify the control of the rotating mechanism. In this embodiment, the smear recognition system 200 includes a stationary holder disposed on the recognition station 01 for receiving the smear 100. When the smear 100 needs to be switched between the first state and the second state on the recognition position 01, the smear gripping device 240 lifts the smear 100 out of the fixing seat, then drives the smear 100 to rotate, and puts the smear 100 back on the fixing seat 234 after the rotation action is completed.

One embodiment referring to fig. 12, after the identification device 210 identifies the tag information 130 of the smear 100 from the first side 110 or the second side 120 of the smear 100, the method further comprises:

s60, the smear gripping device 240 is controlled to place the smear 100 on the inspection stage 02 in a posture in which the first side 110 or the second side 120 faces a predetermined direction for inspection.

The identification of the smear 100 on the label information 130 by the identification means 210 also indirectly identifies whether the smear 100 sample 140 is located on the first side 110 or the second side 120 of the smear 100. When the smear 100 is placed on the detection workbench 02 for detection by the smear gripping device 240, the smear gripping device 240 can be used to adjust the placement state of the smear 100, so as to ensure that the smear 100 is placed on the detection workbench 02 with the outer surface of the smear 100 coated with the sample 140 facing a preset direction (usually, an objective lens of a cell image analyzer) for receiving detection.

In step S60, the smear gripping device 240 may place the smear 100 on the inspection stage 02 with its first side 110 facing a preset direction (see fig. 13) or may place the smear 100 on the inspection stage 02 with its second side 120 facing a preset direction (see fig. 14), depending on whether the identification device 210 identifies the smear' S label information from the first side 110 or the second side 120 of the smear 100.

As can be seen from fig. 13 and 14, the smear gripping apparatus 240 may be constructed in the form of a robot arm. When the smear gripping device 240 places the smear 100 from the recognition site 01 onto the inspection table 02, since the smear 100 may be in a vertical state at the recognition site 01 and the smear 100 is generally placed in a horizontal state on the inspection table 02, the smear gripping device 240 is required to be able to drive the smear 100 to switch between the horizontal state and the vertical state. Therefore, in an embodiment of the present application, the smear gripping device 240 is configured to be tiltable with respect to the inspection table 02 to place the smear 100 on the inspection table 02 in a posture in which the first side 110 or the second side 120 thereof faces a preset direction. Preferably, the smear gripping device 240 is configured to be capable of being turned at least 90 degrees, especially 90 degrees, with respect to the inspection table 02.

The smear gripping device 240 includes a jaw 242 and a supporting body 243, and the jaw 242 is mounted on the supporting body 243 and is used to grip the smear 100. The smear gripping device 240 further includes a turning part 241, through which the gripping jaw 242 is mounted on the supporting body 243, so that the gripping jaw 242 can be turned at least 90 degrees with respect to the supporting body 243, and thus the smear 100 gripped by the gripping jaw 242 can also be turned 90 degrees together, and the posture of the smear 100 is switched between the vertical posture and the horizontal posture. That is, the turning section 241 is used to perform the turning operation of the gripping claw 242 with respect to the rotating device 230 or the detection table 02.

FIG. 13 shows one operation of an embodiment of the present invention to place a smear on a detection stage. The smear gripping device 240 first places the smear 100 in the receiving slot of the rotating device 230 so that the smear 100 is on the recognition site 01 in a vertically placed posture. Then, the recognition device 210 recognizes the smear 100 on the recognition site 01. In fig. 13, the smear 100 label information is carried on the first side 110 of the smear 100 and thus the identification device 210 can identify the smear 100 label information 130 from the first side 110 of the smear 100. Next, the smear gripping device 240 horizontally places the smear 100 in a vertically placed posture on the inspection table 02. Specifically, the smear 100 is placed on the inspection stage 02 with its first side 110 facing vertically upward. The smear gripping device 240 takes out the smear 100 from the rotating device 230 and transports it to the inspection work station 02. In the conveying process, the clamping jaw 242 for clamping the smear 100 is turned over by controlling the turning part 241, and the clamping jaw 242 drives the smear 100 clamped by the clamping jaw to turn over relative to the detection workbench 02, so that the smear 100 is turned over from a vertical state to a horizontal state. The first side 110 of the flipped smear 100 is in a vertically upward orientation. The smear gripping device 240 places the smear 100 on the inspection table 02 with its first side 110 facing a first predetermined direction (vertically upward).

FIG. 14 shows another process of placing a smear on a test table according to an embodiment of the present invention. The difference from figure 13 is that in the scenario of figure 14, the label information 130 of smear 100 is carried at the second side 120 of smear 100. At this time, the identification of the first side 110 by the identification device 210 does not result in the tag information 130 of the smear 100. The rotating device 230 is controlled to rotate the smear 100, so that the second side 120 of the smear 100 is located in the identification range of the identification device 210, and the identification device 210 can identify the second side 120 of the smear 100.

FIG. 15 shows another process of placing a smear on a test table according to an embodiment of the present invention. The difference from fig. 14 is that the smear 100 is horizontally placed on a certain buffer device before being picked up to the recognition site 01. Therefore, when the smear gripping device 240 is controlled to take the smear 100 from the buffer device, the gripper 242 is first turned by 90 degrees relative to the buffer device by the turning part 241 to take the smear 100 in a horizontal posture. Then, in the process of sending the smear 100 to the rotating device 230, the clamping jaw 242 drives the smear 100 clamped by the clamping jaw to turn 90 degrees again through the turning part 241, and the smear 100 in the horizontal state is converted into the vertical state to be placed in the rotating device 230 for identification. The remaining steps can be referred to fig. 13 and 14.

As shown in fig. 16, in an embodiment of the present invention, the smear gripping device 240 includes: a support body 243, a horizontal moving assembly 244, a vertical moving assembly 245, a turning moving assembly 241, and a clamping assembly 242. The vertical moving assembly 245, the reverse moving assembly 241, and the clamping assembly 242 are disposed on the support body 243. The horizontal motion assembly 244 is used to drive the support body along with the vertical motion assembly, the invert motion assembly, and the clamp assembly thereon in horizontal motion. The vertical movement assembly 245 is used to drive the vertical movement of the clamping assembly. The flipping motion assembly 241 is used to drive the gripping assembly to flip relative to the support body.

Referring further to fig. 16a to 16d, a smear gripping device 240 according to an embodiment of the present invention is shown. In fig. 16a, the smear gripping device 240 further comprises a horizontal movement component 244 and a vertical movement component 245, wherein the horizontal movement component 244 and the vertical movement component 245 both drive the object to move on the slide rail by a motor, a synchronous pulley and a synchronous belt, so that the clamping jaw 242 moves in the cell image analyzer 400. The horizontal motion assembly 244 drives the supporting body 243 to move horizontally (in the directions of X1 and X2 in fig. 16 a) together with the vertical motion assembly 245, the flipping motion assembly 241 and the clamping jaw 242 thereon, and the vertical motion assembly 245 drives the clamping jaw 242 to move up and down (in the directions of Y1 and Y2 in fig. 16 a) independently.

Referring to fig. 16b, the turning part 241 includes a motor 2411, a timing pulley 2412, a timing belt 2413, and a rotating shaft 2414. Wherein rotation axis 2414 drives clamping jaw 242 and rotates to realize that clamping jaw 242 drives smear 100 and switches between vertical gesture and horizontal gesture.

Referring to fig. 16c and 16d, the clamping jaw 242 may include a tension spring 2421, a positioning block 2422, a guide rail 2423, a motor 2424, a clamping part 2425 and a cam 2426. The motor 2424 is used for driving the cam 2426 to rotate, when the long edge of the cam 2426 is contacted with the positioning block 2422, the two opposite clamping parts 2425 are opened so as to clamp the smear 100, and after the cam 2426 rotates for 90 degrees again, the two clamping parts 2425 clamp the smear 100 under the tension of the tension spring 2421.

In other embodiments, the turning part 241 may be implemented by a cylinder rotation or a rack and pinion rotation. In other embodiments, a linkage or rack and pinion arrangement may be used in place of the cams 2426 on the jaws 242.

In one embodiment of the invention, when the identification device 210 identifies the label information on the first side 110 or the second side 120 of the smear 100, the identification device 210 can be further controlled to identify whether the smear 100 is present in the identification bit 01. When the identification means 210 identifies the tag information 130 of the smear 100 from either the first side 110 or the second side 120 of the smear 100, it can be determined that the smear 100 is present at the identification location 01. Since the identification of the second side 120 of the smear 100 by the identification device 210 is based on the fact that the identification device 210 does not recognize the tag information at the first side 110 of the smear 100, if the identification device 210 does not recognize the tag information 130 of the smear 100 at the second side 120 of the smear 100, it can be concluded that there is no smear 100 at the recognition site 01 or that the smear 100 is abnormal.

When the recognition means 210 comprises a camera, the area of the recognition bit 01 is photographed by controlling the camera, and the picture of the area of the recognition bit 01 is subjected to feature recognition to determine whether the smear 100 exists in the recognition bit 01.

If it is confirmed that the smear 100 does not exist at the recognition bit 01, the method may further include:

and S70, giving an alarm, or controlling the smear gripping device 240 to grip the next smear 100 to the recognition position 01 for tag information recognition.

Specifically, when the identification device 210 does not identify the tag information on the first side and the second side of the smear 100, an alarm prompt may be sent to the user to notify the user to handle the abnormal situation, or the smear gripping device 240 may be controlled to grip the next smear to the identification position 01 to identify the tag information.

The embodiment of the invention also provides another method for acquiring smear label information, which comprises the following steps of:

s10a, controlling the smear gripping device 240 to place the smear 100 to the recognition position 01, so that the first end 101 of the smear 100 is in the recognition range of the recognition device 210;

s20a, controlling the recognition device 210 to recognize the label information of the first end 101 of the smear 100;

s30a, if the identification device 210 identifies the label information 130 of the smear 100 from the first end 101 of the smear 100, storing the label information 130 of the smear 100;

s40a, if the identification device 210 does not identify the label information of the smear 100 from the first end 101 of the smear 100, controlling the identification device 210 to identify the label information of the second end 102 of the smear 100;

s50a, if the identification device 210 identifies the label information 130 of the smear 100 from the second end 102 of the smear 100, the label information 130 of the smear 100 is stored.

This embodiment provides a method for sequential tag information identification of the first end 101 and second end 102 of the smear 100. The first end 101 and the second end 102 of the smear 100 are the opposite ends of the smear 100 extending in the length direction, respectively. When the smear 100 is placed in the recognition site 01, the recognition device 210 may only recognize the area corresponding to the first end 101 of the smear 100 due to the limited recognition area of the recognition device 210. For example, when the recognition bit 01 is disposed on the rotating device 230, the second end 102 of the smear 100 may not be located in the recognition area of the recognition device 210 due to the shielding of the rotating device 230, and the recognition device 210 cannot recognize the second end 102 of the smear 100.

It should also be noted that the first end 101 and the second end 102 of the smear 100 are not strictly differentiated during the implementation of the method, but merely serve to differentiate the depicted objects, without any sequential or technical implication. For example, the first end 101 and the second end 102 of the smear 100 may be defined relative to the state in which the smear 100 is placed in the recognition bit 01. In an embodiment of the present application, the end of the two opposite ends of the smear 100 initially placed in the recognition site 01 in the length direction 001 within the recognition area of the recognition device 210 can be defined as the first end 101. The embodiment of the application firstly controls the identification device 210 to identify the label information of the first end 101 of the smear 100. Since the smear's label information may also be located at the second end 102, the identification device 210 is unable to identify the smear's label information from the first end 101 of the smear 100. Thus, by adjusting the relative position between the smear 100 and the recognition device 210 such that the second end 102 of the smear 100 is within the recognition area of the recognition device 210, the recognition device 210 is able to perform label information recognition of the second end 102 of the smear 100.

In one embodiment of the invention, S20a may include controlling the recognition device 210 to perform the tag information recognition on the first side 110 and the second side 120 of the first end 101 of the smear 100. When it is confirmed that no tag information is recognized on both sides of the first end 101 of the smear 100, the tag information recognition is performed again on the second end 102 of the smear 100. Likewise, S40a can include controlling the recognition device 210 to recognize the first side 110 and the second side 120 of the second end 102 of the smear 100.

Referring to the illustration of fig. 18, prior to controlling the identification device 210 to identify the tag information at the second end 102 of the smear 100, the method further comprises: the smear gripping device 240 is controlled to grip the smear 100 from the recognition site 01 so that the second end 120 of the smear 100 is within the recognition area of the recognition device 210. It can be understood that the simple translation operation of the smear 100 by the smear gripping device 240 enables the recognition of the first end 101 and the second end 102 of the smear 100 by the recognition device 210, and the structure is simple.

In one embodiment of the invention, when the identification device 210 is performing the identification of the label information on the first side 110 or the second side 120 of the smear 100, the first end 101 and the second end 102 of the first side 110 or the second side 120, respectively, may also be identified.

Referring to the embodiment of fig. 19, the method may further include:

s60a, if the identification device identifies the label information 130 of the smear 100 from the first end 101 or the second end 102 of the smear 100, the smear gripping device 240 is controlled to place the smear 100 on the detection workbench 02 for detection with the first end 101 or the second end 102 facing a preset direction.

Since the coated thickness of the sample in different areas of the smear 100 is different when the smear 100 is prepared, for example, in the direction from the first end 101 to the second end 102, the coated thickness of the sample becomes thinner and thinner. In order to obtain better detection effect, it is usually necessary to select a suitable area on the sample coating for cell shooting, and the suitable area is usually a preset area. Therefore, in order to ensure that the imaging device of the cell image analyzer can photograph the cells of the preset area, the smear 100 may be placed on the detection table 02 in a posture in which the end where the label section is located is directed to the preset direction.

FIG. 20 shows one operation of an embodiment of the present invention to place a smear on a detection stage. Wherein the label information of the smear 100 is disposed on the second end 102, and the smear 100 is placed in the rotating device 230 by the smear gripping device 240 in such a manner that the first end 101 thereof is vertically upward. At this moment, press from both sides the cooperation of getting device 240 through recognition device 210 and smear, the state of placing to smear 100 is discerned and is confirmed that the label information of smear 100 is located second end 102 after, the smear is got device 240 and is being transported smear 100 to detection workstation 02 from rotary device 230 on, smear is got device 240 and is driven smear 100 and overturn for detection workstation 02 to place smear 100 on detection workstation 02 from one side of detection workstation 02, on smear strorage device 220 is placed to the gesture of guaranteeing smear 100's second end 102 orientation default direction.

FIG. 21 shows another process of placing a smear on a test table according to an embodiment of the present invention. The difference from fig. 20 is that the smear 100 is horizontally placed on the buffer device before being picked up to the recognition site 01. Therefore, when the smear gripping device 240 is controlled to take the smear 100 from the buffer device, the gripper 242 is first turned by 90 degrees relative to the buffer device by the turning part 241 to take the smear 100 in a horizontal posture. Then, in the process of sending the smear 100 to the rotating device 230, the clamping jaw 242 drives the smear 100 clamped by the clamping jaw to turn over for 90 degrees again through the turning part 241, and the smear 100 in the horizontal state is converted into the vertical state to be placed into the rotating device 230 for identification. The remaining steps can be referred to fig. 20.

The embodiment of the invention also relates to a method for automatically detecting the smear placement state, which comprises the following steps as shown in FIG. 22:

s101, the smear clamping device 240 clamps the smear 100 to the recognition position 01;

s102, the identification device 210 identifies the label information 130 of the smear 100;

s103, acquiring the placing state of the smear 100 on the recognition position 01 according to the recognition condition of the tag information 130 of the smear 100 by the recognition device 210.

Further, the method may further include:

and S104, if the placement state of the smear 100 does not meet the preset condition, prompting that the placement state of the smear 100 is abnormal.

For example, if the identification means 210 identifies the tag information of the smear 100, it indicates that the smear 100 exists at the identification bit 01 and the smear 100 has the tag information. Conversely, if the identification device 210 does not identify the smear 100 for the tag information, it indicates that there may be no smear 100 at the 01 position, no tag information on the smear 100, or an abnormal identification.

As shown in fig. 2, the smear 100 includes a first side 110 and a second side 120, and a first end 101 and a second end 102, and thus, the placement state of the slide 100 at the recognition site can be judged according to the recognition of the label information from one or one of the sides of the smear 100 by the recognition device 210. As mentioned in the foregoing, the smear 100 label information and the sample are typically located on the same surface of the smear, such as the first side 110 or the second side 120. The side on which the label information and the specimen are located is defined as the front side of the smear, and the other side is the back side.

Referring to fig. 23, in an embodiment of the invention, the method includes the following steps:

s101a, the smear gripping device 240 places the smear 100 to the recognition position 01, so that the first side 110 of the smear 100 is in the recognition range of the recognition device 210;

s102a, the recognition device 210 recognizes the first side 110 of the smear 100;

s103a, if the identification device 210 identifies the label information 130 of the smear 100 from the first side 110 of the smear 100, determining the first side 110 of the smear 100 as the front side of the smear 100;

s104a, if the identification device 210 does not identify the smear 100 label information 130 from the first side 110 of the smear 100, then it is suggested that the smear 100 may be placed side by side.

In this embodiment, only one of the sides of the smear 100 is identified and in the event that no label information is identified, the user is prompted that the smear is not placed correctly, the smear may be placed on the reverse side, requiring the user to deal with the anomaly.

In another embodiment of the present invention, as shown in fig. 24, the method comprises the steps of:

s105a, if the identification device 210 does not identify the label information 130 of the smear 100 from the first side 110 of the smear 100, the identification device 210 identifies the second side 120 of the smear 100;

s106a, if the identification device 210 identifies the label information 130 of the smear 100 from the second side 120 of the smear 100, determining the second side 120 of the smear 100 as the front side of the smear 100;

s107a, if the identification device 210 does not identify the label information 130 of the smear 100 from the second side 120 of the smear 100, then the smear 100 is prompted to be a blank slide or the smear 100 is abnormal or the identification bit 01 does not have the smear 100.

In the embodiment of the present invention, the preset placing state of the smear 100 is defined such that the label information 130 is located on the first side 110 of the smear 100 when the smear 100 is placed at the recognition station 01 by the smear gripping device 240. When the identification device 210 does not identify the label information of the smear 100 from the first side 110 of the smear 100, it indicates that the placement state of the smear 100 at the identification place 01 is abnormal. At this point, the label information 130 of the smear 100 may be on the second side 120, i.e., the smear may be placed on the reverse side. Of course, there may be situations where the smear 100 does not have label information.

The identification device 210 may also be caused to identify the identity information of the second side 120 by adjusting the relative position between the smear 100 and the identification device 210 when the identification device 210 does not recognize the label information from the first side 110 of the smear 100. If the identification means 210 identifies the label information 130 from the second side 120 of the smear 100, the second side 120 of the smear 100 is determined to be the front side of the smear 100.

If the identification means 210 does not identify the identity information from the first side 110 and the second side 120 of the smear 100, there may be situations where the smear 100 is missing label information, the smear 100 is a blank slide, and even there is no smear 100 at the current identification position 01.

It will be appreciated that in fig. 23 and 24, after the front of the smear 100 is determined, the method further includes step S108 a: the smear gripping device 240 is controlled to place the smear 100 on the inspection stage 02 in such a manner that the front surface thereof faces a predetermined direction.

In one embodiment of the present invention, as shown in fig. 25, the method includes the following steps:

s101b, the smear gripping device 240 places the smear 100 to the recognition position 01, so that the first end 101 of the smear 100 is in the recognition range of the recognition device 210;

s102b, the identification device 210 identifies the first end 101 of the smear 100;

s103b, if the identification device 210 identifies the label information 130 of the smear 100 from the first end 101 of the smear 100, determining that the first end 101 of the smear 100 is the label section of the smear 100;

s105b, if the identification device 210 does not identify the label information 130 of the smear 100 from the first end 101 of the smear 100, the identification device 210 identifies the second end 102 of the smear 100;

s106b, if the identification device 210 identifies the label information 130 of the smear 100 from the second end 102 of the smear 100, determining the second end 102 of the smear 100 as the label section of the smear 100;

s107b, if the identification device 210 does not identify the label information 130 of the smear 100 from the second end 102 of the smear 100, it is prompted that the smear 100 may be a blank slide or the smear 100 is abnormal or the identification bit 01 does not have the smear 100.

In the present embodiment, the preset placement state of the smear 100 is further defined as the label information 130 located on the first side 110 of the smear 100 and at the first end 101 when the smear 100 is placed at the recognition site 01 by the smear gripping device 240. When the identification means 210 does not identify the tag information of the smear 100 from the first end 101 of the smear 100, it indicates that the placement state of the smear 100 at the identification place 01 is abnormal. At this point, the label information 130 of the smear 100 may be located on the second end 102, i.e., the smear may be placed upside down. Of course, there may be situations where the smear 100 does not have label information.

In another embodiment of the present invention, the method may further include: s104b, if the identification device 210 does not identify the smear 100 label information 130 from the first end 101 of the smear 100, then it is suggested that the smear 100 may be placed upside down.

It will be appreciated that after determining the end of the smear 100 at which the label section is located, the method further comprises: s108b, adjusting the posture of the smear 100 based on the placement state of the smear 100, and controlling the smear gripping device 240 to place the smear 100 on the inspection table 02 with the tab section thereof facing the preset direction.

In some embodiments, the label section has its own label zone characteristics, e.g., the label section has a particular color. In some embodiments, the label area features of the label section are present on both sides of the smear. Thus, the end where the tab section is located can also be identified by identifying whether the first end 101 and the second end 102 of the smear 100 have the tab area features.

In the embodiment of the invention, the identification device 210 is used for identifying the label information 130 of the smear 100 and identifying whether the smear 100 is placed in a positive or negative and/or upside down, namely, the placement state of the smear 100 at the identification position 01 is judged, and the smear gripping device 240 is controlled to place the smear 100 on the detection workbench 02 in a correct posture based on the placement state of the smear 100 in the follow-up process.

FIG. 26 illustrates a method for automatically detecting the smear placement status according to one embodiment of the present invention. The smear 100 is first placed to the recognition site 01 by the smear gripping device 240 so that the first side 110 and the first end 101 of the smear 100 are within the recognition range of the recognition device 210. The first end 101 of the first side 110 of the smear 100 is then barcode scanned and image acquired by a barcode scanner and camera, either sequentially or simultaneously. When the barcode scanner or camera recognizes the label information from the first end 101 of the first side 110 of the smear 100, it indicates that the first side 110 of the smear 100 is the front side. If neither the barcode scanner nor the camera recognizes the label information from the first end 101 of the first side 110 of the smear 100, barcode scanning and image acquisition are performed sequentially or simultaneously by the barcode scanner and the camera on the first end 101 of the second side 120 of the smear 100. When the barcode scanner or camera recognizes the label information from the first end 101 of the second side 120 of the smear 100, it indicates that the second side 120 of the smear 100 is a front side. If neither the barcode scanner nor the camera recognizes the label information from the first end 101 of the second side 120 of the smear 100 and the label zone characteristics of the label section cannot be acquired from the images of the first side 110 and the second side 120 acquired by the camera, this indicates that the smear 100 may be placed upside down or that no smear is present, and vice versa indicates that the smear 100 is a blank slide.

By the method provided by the embodiment of the invention, various placing states of the smear 100 at the recognition position 01 can be recognized, and the placing state of the smear 100 is corrected through subsequent automatic adjustment, so that the smear 100 can be accurately placed on the detection workbench 02 in a preset state for detection; or, the recognized placement state of the smear 100 can be prompted to the user so that the user can check out the abnormal situation, for example, the smear 100 with the placement state being reversed and/or inverted is adjusted accordingly so as to ensure that the smear 100 can be accurately placed on the detection workbench 02 in the preset state for detection. Thereby the risk of a smear 100 being placed incorrectly on the inspection station 02 can be reduced.

As shown in fig. 27, the embodiment of the present invention further provides a cytoimage analyzer 400, which includes an imaging device 410, a smear moving device 420, a smear recognition system 200, and an image analyzing device 440.

The imaging device 410 comprises a lens group 411 and a camera 412 for taking images of the cells in the sample 140 smeared on the smear 100. The smear moving device 420 is used to carry the smear 100 and adjust the relative positions of the smear 100 and the imaging device 410 so that the imaging device 410 takes a cell image of a specific area of the smear 100. The smear recognition system 200 serves to recognize the tag information 130 of the smear 100 and place the smear 100 on the smear moving device 430 in a correct posture for examination, or the smear recognition system 200 serves to place the smear 100 on a smear buffering device (not shown) provided in the cytological image analyzer 400 in a correct posture, the smear buffering device being configured to be movable relative to the smear moving device 420 so that the smear 100 stored on the smear buffering device can be pushed into the smear moving device 420 for examination. The image analysis device 440 is used to analyze images of cells in a sample smeared on the smear 100.

The smear identification system 200 of the cytological image analyzer 400 can refer to the description of the above embodiments, and will not be described in detail here.

The present invention relates to a cell image analyzer 400 which, after reading the tag information 130, particularly the identity information, of the smear 100 to be tested, takes a cell image of the smear 100 to be tested and stores the cell image of the smear 100 in association with the identity information, so that an operator can obtain specific test data corresponding to the identity information.

As shown in fig. 28, the lens group 411 may include a first objective lens 4111 and a second objective lens 4112. The first objective lens 4111 may be, for example, a 10-fold objective lens, and the second objective lens 4112 may be, for example, a 100-fold objective lens. The lens group 411 may further include a third objective lens 4113, and the third objective lens 4113 may be a 40-fold objective lens, for example. Lens group 411 may also include eyepiece 4114.

The embodiment of the invention also relates to a computer readable storage medium which comprises a storage device. Wherein the storage device stores executable instructions and is configured to cause the processor to execute the executable instructions to implement the above-described method for acquiring smear label information and method for automatically detecting a smear placement state.

The storage device may include a volatile memory device (volatile memory), such as a random-access memory (RAM); or a non-volatile memory device (non-volatile memory), such as a flash memory device (flash memory), a solid-state drive (SSD), or the like; or a combination comprising storage means of the kind described above.

The Processor may be a Central Processing Unit (CPU), or other general purpose Processor, a Digital Signal Processor (DSP), an Application Specific Integrated Circuit (ASIC), an off-the-shelf Programmable Gate Array (FPGA) or other Programmable logic device, discrete Gate or transistor logic, discrete hardware components, or the like. A general purpose processor may be a microprocessor or the processor may be any conventional processor or the like.

It should be noted that the development of the embodiments of the present invention in the cytological image analyzer and the computer-readable storage medium can be realized by referring to the explanation of the corresponding embodiments of the above-mentioned smear identification system and the method for acquiring smear label information and the method for automatically detecting the smear placement status.

The features mentioned above in the description, the claims and the drawings can be combined with one another in any way as far as they are meaningful within the scope of the invention, and do not constitute a limitation on the scope of protection of this solution. Any modification, equivalent replacement, and improvement made within the spirit and principle of the above-described embodiments should be included in the protection scope of the technical solution.

Claims

A method of obtaining smear label information, the smear including opposed first and second faces extending lengthwise thereof and including a label section for carrying label information, the smear carrying the label information on either the first or second face, the method comprising:

controlling a smear gripping device to place the smear to a recognition position so that a first side of the smear is within a recognition range of a recognition device;

controlling the identification device to identify the label information of the first surface of the smear;

if the identification device identifies the label information of the smear from the first side of the smear, storing the label information of the smear;

if the identification device does not identify the label information of the smear from the first side of the smear, controlling the identification device to identify the label information of the second side of the smear;

and if the identification device identifies the label information of the smear from the second side of the smear, storing the label information of the smear.
The method of claim 1 wherein the tag information comprises identity information of the smear.
The method according to claim 1 or 2, wherein the identification device comprises a camera or a barcode scanner, and the controlling the identification device to perform the tag information identification on the first side or the second side of the smear comprises:

controlling the camera to take a picture of the first surface or the second surface of the smear so as to perform feature recognition on the picture acquired by the camera and extract label information of the smear; or

And controlling the bar code scanner to perform bar code scanning on the first surface or the second surface of the smear so as to extract the label information of the smear.
The method of claim 1 or 2 wherein the identification device comprises a camera and a barcode scanner, and the controlling the identification device to identify the label information on the first side or the second side of the smear comprises:

controlling the camera to take a picture of the first surface or the second surface of the smear so as to perform feature recognition on the picture acquired by the camera and extract label information of the smear; and

and controlling the bar code scanner to perform bar code scanning on the first side or the second side of the smear so as to extract the label information of the smear.
The method of claim 1 or 2 wherein the identification device comprises a camera and a barcode scanner, and the controlling the identification device to identify the label information on the first side or the second side of the smear comprises:

controlling the bar code scanner to perform bar code scanning on the first surface or the second surface of the smear so as to extract label information of the smear;

and if the bar code scanner does not extract the label information of the smear, controlling the camera to photograph the first surface or the second surface of the smear so as to perform feature recognition on the photo obtained by the camera and extract the label information of the smear.
The method according to any one of claims 1 to 5 wherein said controlling said recognition device to perform a tag information recognition on the second side of said smear comprises:

controlling the smear gripping device to adjust the smear from a first state to a second state so that a second side of the smear is within a recognition range of the recognition device.
The method according to any one of claims 1 to 5 wherein said controlling said recognition device to perform a tag information recognition on the second side of said smear comprises:

controlling the recognition device to rotate around the recognition bit so that the second side of the smear is within a recognition range of the recognition device.
The method according to any one of claims 1 to 5, wherein the controlling the smear gripping device to place the smear to an identification position comprises: controlling the smear gripping device to place the smear into a rotating device rotatable about its central axis such that a first side of the smear is within a recognition area of the recognition device;

before the control of the recognition device to perform the identification of the label information on the second side of the smear, the method comprises the following steps: and controlling the rotating device to drive the smear contained by the rotating device to rotate, so that the second surface of the smear is positioned in the identification range of the identification device.
The method according to any one of claims 1 to 5,

the control the recognition device carries out label information recognition on the first surface of the smear, and the control method comprises the following steps: controlling a first identification mechanism of the identification device to identify the label information of the first surface of the smear;

the control device is used for carrying out label information recognition on the second side of the smear and comprises the following steps: and controlling a second identification mechanism of the identification device to identify the label information of the second side of the smear.
The method according to any one of claims 1 to 9, further comprising:

and if the identification device identifies the label information of the smear from the first surface or the second surface of the smear, controlling the smear clamping device to place the smear on a detection workbench for detection in a posture that the first surface or the second surface of the smear faces to a preset direction.
The method according to any one of claims 1 to 10, wherein when controlling the recognition device to perform the tag information recognition on the first side or the second side of the smear, further comprising:

and controlling the identification device to identify whether the smear exists in the identification position.
The method according to claim 11, wherein the controlling the recognition device to recognize whether the smear is present in the recognition bit comprises:

controlling a camera to photograph the area of the identification position;

and performing feature recognition on the picture of the area of the identification position to determine whether the smear exists in the identification position.
The method according to claim 11 or 12, characterized in that the method further comprises:

and if the identification device identifies that no smear exists in the identification position, alarming for prompting, or controlling the smear clamping device to clamp and take down one smear to the identification position for label information identification.
A method of obtaining smear label information, the smear comprising opposed first and second ends along its length and a label section for carrying label information, the smear being provided with the label section at either the first or second end, the method comprising:

controlling a smear clamping device to place a smear to a recognition position so that a first end of the smear is within a recognition range of a recognition device;

controlling the identification device to identify the label information of the first end of the smear;

if the identification device identifies the label information of the smear from the first end of the smear, storing the label information of the smear;

if the identification device does not identify the label information of the smear from the first end of the smear, controlling the identification device to identify the label information of the second end of the smear;

and if the identification device identifies the label information of the smear from the second end of the smear, storing the label information of the smear.
The method according to claim 14 wherein said controlling said identification device to perform said tag information identification of said second end of said smear comprises:

and controlling the smear gripping device to grip the smear from the identification position, so that the second end of the smear is positioned in the identification area of the identification device.
The method according to claim 14 or 15, characterized in that the method further comprises:

and if the identification device identifies the label information of the smear from the first end or the second end of the smear, controlling the smear clamping device to place the smear on a detection workbench for detection in a posture that the first end or the second end of the smear faces to a preset direction.
A method for automatically detecting the smear placement status, the method comprising:

the smear clamping device clamps a smear to the identification position, and the smear comprises a label section capable of bearing label information;

the identification device identifies the label information of the smear;

and acquiring the placing state of the smear on the identification position according to the identification condition of the identification device on the label information of the smear.
The method of claim 17, further comprising:

and if the placement state of the smear does not meet the preset condition, prompting that the placement state of the smear is abnormal.
The method according to claim 17 or 18 wherein the smear comprises first and second opposed faces extending lengthwise thereof, the smear having a front face bearing label information and applying the sample;

the smear is got the device and is got the smear clamp and get the recognition bit, include: the smear gripping device places the smear to an identification position so that a first side of the smear is within an identification range of the identification device;

the recognition device recognizes the label information of the smear, including: the identification device identifies the first surface of the smear;

and if the identification device identifies the label information of the smear from the first side of the smear, determining that the first side of the smear is the front side of the smear.
The method of claim 19, further comprising:

if the identification device does not identify the label information of the smear from the first side of the smear, the smear is prompted to be possibly placed on the reverse side.
The method of claim 19 or 20,

the recognition device recognizes the label information of the smear, including: if the identification device does not identify the label information of the smear from the first side of the smear, the identification device identifies the second side of the smear;

and if the identification device identifies the label information of the smear from the second side of the smear, determining the second side of the smear as the front side of the smear.
The method of claim 21, further comprising:

if the identification device does not identify the label information of the smear from the second side of the smear, the smear is prompted to be a blank slide or the smear is abnormal or the identification position has no smear.
The method according to any one of claims 17 to 22 wherein the smear comprises first and second opposed lengthwise ends, the smear having either the first or second end provided with the label section;

the smear is got device and is placed the smear and distinguish the position and include: the smear gripping device places the smear to an identification position so that a first end of the smear is within an identification range of the identification device;

the recognition device recognizes the label information of the smear, including: the identification device identifies a first end of the smear;

if the identification device identifies the label information of the smear from the first end of the smear, determining the first end of the smear as a label section of the smear;

if the identification device does not identify the label information of the smear from the first end of the smear, the identification device identifies the second end of the smear;

and if the identification device identifies the label information of the smear from the second end of the smear, determining that the second end of the smear is the label section of the smear.
A smear recognition system for obtaining smear label information, the smear including opposed first and second sides extending along a length thereof and including a label section for carrying label information, the smear carrying the label information on either the first or second side thereof, the smear recognition system comprising:

the smear clamping device is used for clamping the smear to the identification position;

the identification device is used for identifying the label information of the smear on the identification position;

a control device electrically connected with the smear gripping device and the recognition device and configured to:

controlling the smear gripping device to place the smear to a recognition position so that a first side of the smear is within a recognition range of a recognition device;

controlling the identification device to identify the label information of the first surface of the smear;

if the identification device identifies the label information of the smear from the first side of the smear, storing the label information of the smear;

if the identification device does not identify the label information of the smear from the first side of the smear, controlling the identification device to identify the label information of the second side of the smear;

and if the identification device identifies the label information of the smear from the second side of the smear, storing the label information of the smear.
The smear recognition system of claim 24 wherein the recognition device comprises a camera for taking a picture of the smear's tab section to perform feature recognition on the picture taken by the camera and extract the smear's tab information,

and/or the identification device comprises a bar code scanner for performing bar code scanning on the smear so as to extract the label information of the smear.
A smear recognition system according to claim 24 or 25 comprising a rotation device arranged at the recognition site, the rotation device being configured to receive the smear and being configured to be rotatable so as to bring the received smear into rotation.
The smear recognition system of claim 26 wherein the rotation device is configured to be rotatable at least 180 degrees in a predetermined rotational direction.
A smear recognition system according to claim 26 or 27 wherein the rotation means is configured to be rotatable 360 degrees in the predetermined rotational direction.
The smear recognition system according to any one of claims 26 to 28 wherein a receptacle is provided within the rotating means, the receptacle being open at the top so that the smear can be placed into the receptacle from the opening.
The smear recognition system of any one of claims 26 to 29 wherein the control means is further configured to:

controlling the smear gripping device to grip the smear onto the rotating device so that a first side of the smear is within an identification area of the identification device;

if the identification device does not identify the label information of the smear from the first surface of the smear, the rotation device is controlled to drive the smear contained in the rotation device to rotate, so that the second surface of the smear is positioned in the identification area of the identification device, and the identification device can conveniently identify the second surface of the smear.
A smear recognition system according to claim 24 or 25 wherein the smear gripper is further configured to be rotatable along its axis.
The smear recognition system of claim 31 wherein the control device is further configured to:

if the identification device does not identify the label information of the smear from the first surface of the smear, the smear clamping device is controlled to drive the smear clamped by the smear clamping device to rotate, so that the second surface of the smear is located in the identification area of the identification device, and the identification device can conveniently identify the second surface of the smear.
The smear recognition system according to any one of claims 24 to 32, wherein the smear gripping device is further configured to move in vertical and horizontal directions and to place the smear on a detection table in a posture that the first or second side thereof faces a preset direction for detection when the recognition device recognizes the smear's tag information from the first or second side of the smear.
The smear recognition system according to claim 33, wherein the smear gripper comprises: the device comprises a supporting main body, a horizontal movement assembly, a vertical movement assembly, a turnover movement assembly and a clamping assembly;

the vertical motion assembly, the overturning motion assembly and the clamping assembly are arranged on the supporting main body, the horizontal motion assembly is used for driving the supporting main body to move horizontally together with the vertical motion assembly, the overturning motion assembly and the clamping assembly on the supporting main body, the vertical motion assembly is used for driving the clamping assembly to move vertically, and the overturning motion assembly is used for driving the clamping assembly to overturn relative to the supporting main body.
The smear recognition system of claim 34 wherein the reversing motion assembly is configured to drive the gripper mechanism to reverse 90 degrees relative to the support body.
The smear recognition system according to any one of claims 24 to 35 wherein the control means is further adapted to implement the method according to any one of claims 1 to 23.
A cellular image analyzer, comprising:

the digital imaging device comprises a lens group and a digital camera and is used for shooting the image of the cells on the smear;

the smear moving device is provided with a detection workbench and is used for adjusting the relative position of the digital imaging device and the smear;

the smear recognition system of any one of claims 24 to 36.
A computer readable storage medium storing executable instructions configured to cause a processor to carry out the method of any one of claims 1 to 23 when the executable instructions are executed.