CN114746070A - Sunscreen compositions with multiple photoprotective UV filters - Google Patents

Sunscreen compositions with multiple photoprotective UV filters Download PDF

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CN114746070A
CN114746070A CN202080080833.7A CN202080080833A CN114746070A CN 114746070 A CN114746070 A CN 114746070A CN 202080080833 A CN202080080833 A CN 202080080833A CN 114746070 A CN114746070 A CN 114746070A
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filter
broadband
ethylhexyl
sunscreen
sunscreen composition
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马克·皮萨文尼
卡里纳·朱利安
卡里纳·吉耶莱尔米内特
奥利弗·杜塞
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Coty Inc
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35Ketones, e.g. benzophenone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37Esters of carboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4926Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings

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  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Cosmetics (AREA)
  • Optical Filters (AREA)

Abstract

Provided is a UV filter composition comprising: three UV-B filters; a UV-A filter; and UV-A + UV-B broadband filters.

Description

Sunscreen compositions with multiple photoprotective UV filters
RELATED APPLICATIONS
The present application claims the benefit of priority from U.S. provisional patent application serial No. 62/937,989 entitled "SUNSCREEN composition WITH MULTIPLE photoprotective UV FILTERS" (SUNSCREENs composition WITH MULTIPLE photoprotective UV FILTERS) "filed on 20/11/2019, the disclosure of which is incorporated herein by reference in its entirety. This application also claims the benefit of priority from U.S. provisional patent application serial No. 62/948,990 entitled "sunscreen composition with multiple photoprotective UV filters" filed on 2019, 12, month 17, the disclosure of which is incorporated herein by reference in its entirety.
Disclosed herein are novel compositions for use as sunscreens comprising a plurality of photoprotective UV filters. The combination of UV filters provides effective protection from a wide range of UV wavelengths when applied to exposed skin.
Technical Field
Background
Exposure to sunlight poses health risks, the significance of which has increased over the last few decades. Acute exposure to the sun can lead to sunburn, which is characterized by skin irritation and redness. More importantly, prolonged exposure to the sun increases the risk of skin cancer. Among the various subtypes of skin cancer, melanoma has the greatest risk because melanoma is aggressive and difficult to treat if not captured before spreading. The American Cancer Society estimates that nearly 100,000 melanoma cases will be diagnosed in 2019 with about 7,000 deaths. Finally, exposure to sunlight can cause premature skin aging, hair damage, and eye damage (including cataracts).
The ultraviolet region of solar radiation falling between 200nm and 400nm can be classified into three regions: 320nm to 400nm (UV-A), 290nm to 320nm (UV-B) and 200nm to 290nm (UV-C), the latter (UV-C) generally not penetrating the earth's atmosphere. Historically, more concern was the health risk of UV-B exposure; recently, however, there has been much understanding of the damage that potentially could be caused by UV-a, as well as melanoma and other skin cancers. Therefore, protection from excessive UV-A and UV-B radiation is an important part of personal care.
Despite the long history of sunscreen use in the market, the newly discovered health and (especially) environmental issues are promoting the development of new compounds and compositions for improved prophylactic properties and increased consumer acceptance. The need for a method for new sunscreens is significantly unmet. The present disclosure satisfies these and other needs, as evidenced by reference to the following disclosure.
The invention provides a sunscreen cream composition.
Provided is a UV filter composition comprising: three UV-B filters; a UV-A filter; and UV-A + UV-B broadband filters.
Disclosure of Invention
Also provided is a sunscreen composition comprising the UV filter composition described herein.
Also provided is a method for protecting skin from the sun, the method comprising applying to the skin a sunscreen composition described herein.
These and other aspects of the invention will be apparent from and elucidated with reference to the embodiments described hereinafter. To this end, various references are set forth herein which describe in more detail certain background information, procedures, compounds and/or compositions, and are each incorporated by reference herein in its entirety.
Drawings
The drawings illustrate generally, by way of example, but not by way of limitation, various embodiments discussed in this document.
Figure 1 is a graph showing that the in vivo SPF of formulas 1 and 2 is substantially the same as the SPF of the comparative formula according to example 5.
Fig. 2 is a graph showing that PPD of formula 1 is substantially the same as the comparative formula according to example 5.
Figure 3 is a graph showing the SPF/PPD quotient of formula 1 substantially the same as the comparative formula according to example 5.
Fig. 4 is a graph showing the improvement of SPF of equation 3 over the comparative equation according to example 5.
Figure 5 is a graph showing the SPF/PPD quotient of formula 3 substantially the same as the comparative formula according to example 5.
Figure 6 is a graph showing the SPF/PPD quotient of formula 3 substantially the same as the comparative formula according to example 5.
Detailed Description
In the following description, certain specific details are set forth in order to provide a thorough understanding of various embodiments. However, it will be understood by those of ordinary skill in the art that the present invention may be practiced without these details. In other instances, well-known structures have not been shown or described in detail to avoid unnecessarily obscuring the description of the embodiments. Throughout the specification and the claims which follow, unless the context requires otherwise, the word "comprise", and variations such as "comprises" and "comprising", will be interpreted in an open-ended and inclusive sense, i.e., as "including but not limited to". Further, the headings provided herein are for convenience only and do not interpret the scope or meaning of the claimed invention.
Reference throughout this specification to "one embodiment" or "an embodiment" or "some embodiments" or "a certain embodiment" means that a particular feature, structure or characteristic described in connection with the embodiment is included in at least one embodiment. Thus, appearances of the phrases "in one embodiment" or "in an embodiment" or "in some embodiments" or "in an embodiment" in various places throughout this specification are not necessarily all referring to the same embodiment. Furthermore, the particular features, structures, or characteristics may be combined in any suitable manner in one or more embodiments.
Also, as used in this specification and the appended claims, the singular forms "a," "an," and "the" include plural referents unless the content clearly dictates otherwise.
Where applicable, chemicals are specified according to their INCI names. Additional information, including definitions, supplier and commodity names, may be found in the International Cosmetic Ingredient Dictionary and Handbook, published by Personal Care Products Council, Washington d.c., in the Washington, 16 th edition, in the appropriate INCI monograph. It is also available from the Personal Care Products Council On-Line information base (http:// online. Personal Care output. org/jsp/Home. jsp).
When disclosing ranges of values and using "from n1To n2"or" between n1And n2Symbol between, where n1And n2To a number, such notation is intended to encompass the number itself and ranges between the numbers unless otherwise indicated. This range may be an integer or may be between and inclusive of the endpoints. For example, a range of "2 to 6 carbons" is intended to include two, three, four, five, and six carbons, as carbons are present in integer units. For example, 1 μ M to 3 μ M (micromolar) intended to encompass 1 μ M, 3 μ M and each number therebetween is compared to any of the significant figures (e.g., 1.255 μ M, 2.1 μ M, 2.9999 μ M, etc.).
As used herein, the term "about" is intended to quantify what it modifies, thereby indicating that such values are variable within a margin of error. When a specific margin of error is not recited, such as the standard deviation from the mean value given in the data sheet or table, the term "about" should be understood to mean that the range of values recited and the range by rounding to the stated number is intended to be encompassed, thereby taking into account the significant figure.
Unless otherwise indicated, percentages or concentrations refer to percentages or concentrations by weight (i.e.,% (W/W)). Unless otherwise indicated, all ranges are inclusive, e.g., "from 4 to 9" includes the endpoints 4 and 9.
As used herein, the term "cosmetically effective amount" refers to an amount of a physiologically active compound or composition that is sufficient to treat one or more conditions, but low enough to avoid serious side effects. The cosmetically effective amount of the compound or composition will vary with the condition being treated, the age and physical condition of the end user, the severity of the condition being treated/prevented, the duration of the treatment, the nature of the other treatments, the particular compound or product/composition employed, the cosmetically acceptable carrier used, and the like.
As used herein, the term "cosmetically acceptable" means a composition whose ingredients are suitable for use in contact with tissue (e.g., skin) without undue toxicity, irritation, incompatibility, instability, allergic response, or other adverse effect.
The term "sun protection factor", abbreviated "SPF", or "UV protection factor" is determined using a combination of experimental and theoretical absorption data disclosed in US 6,820,014, which is incorporated herein by reference. Other methods for determining SPF are known in the art.
The term "persistent pigment darkening", abbreviated "PPD", is a method of measuring UVA protection, similar to the SPF method of measuring sunburn protection. Instead of measuring erythema, the PPD method uses UVA radiation to cause a sustained darkening or tanning of the skin. Theoretically, a sunscreen with a PPD rating of 10 should allow for 10 times more UVA exposure than without protection. Methods for determining PPD are known in the art.
As used herein, the term "UV-a" refers to electromagnetic radiation having a wavelength between 320nm and 400 nm.
As used herein, the term "UV-B" refers to electromagnetic radiation having a wavelength between 290nm and 320 nm.
As used herein, the term "broad spectrum" UV refers to electromagnetic radiation having wavelengths of 290nm to 400 nm. The "broad spectrum" was determined according to 21c.f.r.201.327(j) (2019).
As used herein, the term "critical wavelength" is a wavelength that is 90% of the integral within the UV spectrum of 290nm to 400nm of the integral of the spectral absorbance curve.
As used herein, the term "photostable" refers to molecules that are capable of remaining intact upon irradiation. Photostability can be quantified later by comparing the degree of protection with the illumination. See, e.g., pissvini et al (2012) "New Method to Reproduce the discovery of the Photostability of In Vitro Cosmetic products" (New Method to reproduction In Vitro Cosmetic Product Cosmetics accessories), "Cosmetics and Toiletries (Cosmetics & Toiletries) 127 (3): 208, 218, which are incorporated by reference for all purposes. Other methods known in the art can also be used to determine photostability.
As used herein, the term "topical application" refers to direct application by spraying, wiping, or coating on the skin or scalp. Topical application can be by hand or using an applicator such as a wipe, roller or spray.
As used herein, the term "cosmetic agent" refers to a substance or formulation that maintains, restores, imparts, simulates or enhances the aesthetic appearance of the body or appears to enhance beauty or youth, particularly as it relates to the appearance of tissue or skin.
As used herein, the term "sunscreen composition" refers to a formulation that absorbs and/or reflects some of the solar Ultraviolet (UV) radiation, including, but not limited to: sprays, oils, lotions, creams, gels, butters, pastes, ointments, sticks, powders, wipes, towels, body washes, shampoos, or other topical products. Sunscreen compositions will therefore provide protection against the negative effects of sun exposure, e.g., sunburn, premature aging, etc.
Provided is a UV filter composition comprising: three UV-B filters; a UV-A filter; and UV-A + UV-B broadband filters. Also provided is a UV filter composition consisting of: three UV-B filters; a UV-A filter; and UV-A + UV-B broadband filters.
In certain embodiments, the UV-a filter is selected from:
butyl methoxydibenzoylmethane or 1- (4-tert-butylphenyl) -3- (4-methoxyphenyl) propane-1, 3-dione;
p-xylylene dicamphor sulfonic acid or 3, 3' - (1, 4-phenylenedimethylene) bis (7, 7-dimethyl-2-oxobicyclo- [2.2.1] hept-1-ylmethanesulfonic acid) and salts thereof;
menthyl anthranilate;
disodium phenyl dibenzoimidazole tetrasulfonate (bisdisullizole Disodium or Disodium phenyl dibenzodizonium tetrasulfonate);
diethylaminohydroxybenzoylbenzoic acid hexyl ester; and
dimethoxyphenyl- [1- (3, 4) ] -4, 4-dimethyl-1, 3-pentanedione.
In certain embodiments, the UV-a filter is selected from butyl methoxydibenzoylmethane, diethylamino hydroxybenzoyl hexyl benzoate, disodium phenyldibenzoyl imidazole tetrasulfonate, and p-xylylene dicamphor sulfonic acid.
In certain embodiments, the UV-a filter is selected from: butyl methoxydibenzoylmethane and menthyl anthranilate.
In certain embodiments, the UV-a filter is butyl methoxydibenzoylmethane.
In certain embodiments, the three UV-B filters are independently selected from:
3-benzylidene camphor;
benzylidene camphor sulfonic acid;
enzacamine (enzacarnene) or 4-methylbenzylidenecamphor or 4-MBC;
2-ethoxyethyl-p-methoxy octanoate;
DEA methoxy cinnamate;
isostearyl alcohol (Iscotrizinol) or diethylhexyl butamido triazone or benzoic acid, 4, 4- { [6- [ [ [ (1, 1-dimethylethyl) amino ] carbonyl ] phenyl ] amino ] -1, 3-5-triazine-2, 4-diyl ] diimino } bis-, bis (2-ethylhexyl) ester;
bisdiacyl trioleate;
diisopropylmethyl cinnamon;
ethyl dihydroxypropyl PABA;
ethylhexyl dimethoxybenzylidenedioxoimidazopropionate;
octyl dimethyl-PABA or 2-ethylhexyl 4- (dimethylamino) benzoate;
octyl methoxycinnamate or 2-ethylhexyl 4-methoxycinnamate;
octyl salicylate or 2-ethylhexyl salicylate;
octyl-or ethylhexyl-triazinone or 2, 4, 6-trianilino- (p-carbo-2 '-ethylhexyl-1' -oxy) -1, 3, 5-triazine;
ferulic acid;
ethyl hexanoate dimethoxycinnamic acid glycerol ester;
glyceryl PABA;
benzoic acid, 2-hydroxy-, 3, 3, 5-trimethylcyclohexyl ester;
isoamyl p-methoxycinnamate or isoamyl-4-methoxycinnamate;
isopentyl trimethoxy cinnamate trisiloxane;
isopropyl benzyl salicylate;
isopropyl methoxycinnamate;
lawsone) + dihydroxyacetone;
4-methylbenzylidenecamphor;
2-ethylhexyl 2-cyano-3, 3-diphenylacrylate;
aminobenzoic acid (PABA);
·PEG-25PABA;
amyl dimethyl PABA;
phenylbenzimidazole sulfonic acid or 2-phenylbenzimidazole-5-sulfonic acid and the potassium, sodium and triethanolamine salts thereof;
polyacrylamidomethylbenzylidenecamphor;
polysiloxane-15 or dimethicone diethylbenzylidene malonate;
salicylic acid; and
salicylic acid TEA (triethanolamine salicylate).
In certain embodiments, the three UV-B filters are independently selected from ethylhexyl dimethyl PABA, ethylhexyl methoxycinnamate, ethylhexyl salicylate, homosalate (homosalate), octocrylene (octocrylene), PABA, and phenylbenzimidazole sulfonic acid. In certain embodiments, any of the compositions described herein may be free of octocrylene.
In certain embodiments, the three UV-B filters are independently selected from the group consisting of 3-benzylidenecamphor, benzylidenecamphor sulfonic acid, camphorbenzazapine methyl sulfate, diethylhexylbutamido triazone, ethylhexyl dimethyl PABA, ethylhexyl methoxycinnamate, ethylhexyl salicylate, ethylhexyl triazone, homosalate, isoamyl p-methoxycinnamate, 4-methylbenzylidene camphor, octocrylene, PABA, PEG-25PABA, phenylbenzimidazole sulfonic acid, polyacrylamidomethylbenzylidene camphor, and polysiloxane-15. In certain embodiments, the three UV-B filters are independently selected from cinoxate (cinoxate), ethylhexyl dimethyl PABA, ethylhexyl methoxycinnamate, ethylhexyl salicylate, homosalate, octocrylene, PABA, phenylbenzimidazole sulfonic acid, and TEA salicylate. In certain embodiments, the three UV-B filters are independently selected from isoamyl p-methoxycinnamate, ethylhexyl triazone, diethylhexyl butamido triazone, and ethylhexyl salicylate. In certain embodiments, the three UV-B filters are independently selected from isoamyl p-methoxycinnamate, ethylhexyl triazone, and octyl salicylate.
In certain embodiments, the broadband UV-a and UV-B filters are selected from:
benzophenone;
benzophenone-1;
benzophenone-2;
benzophenone-3 or 2-hydroxy-4-methoxybenzophenone;
benzophenone-4 or 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid (benzophenone-5) and its sodium salt;
benzophenone-5;
benzophenone-6;
dihydroxybenzone (Dioxybenzone, benzophenone-8);
benzophenone-9;
beta-2-glucopyranosyloxypropylhydroxybenzophenone;
benmotriazinol (Bemotrizinol) or bis-ethylhexyloxyphenol methoxyphenyl triazine or 2, 2' - (6- (4-methoxyphenyl) -1, 3, 5-triazine-2, 4-diyl) bis (5- ((2-ethylhexyl) oxy) phenol);
cresoltrazole (Drometrizole);
cresol troxazole trisiloxane or phenol, 2- (2H-benzotriazol-2-yl) -4-methyl-6- (2-methyl-3- (1, 3, 3, 3-tetramethyl-1- (trimethylsilyl) oxy) -disiloxanyl) propyl;
yooktriazole (Bisoctrizol) or methylenebis-benzotriazolyl tetramethylbutylphenol;
titanium dioxide; and
zinc oxide.
In certain embodiments, the broadband UV-A and UV-B filters are selected from benzophenone-3 and titanium dioxide. In certain embodiments, the broadband UV-a and UV-B filters are selected from benzophenone-3, benzophenone-4, benzophenone-5, bis-ethylhexyloxyphenol methoxyphenyl triazine, cresoltrazol trisiloxane, methylene bis-benzotriazolyl tetramethylbutylphenol, and titanium dioxide. In certain embodiments, the broadband UV-A and UV-B filters are selected from benzophenone-3, benzophenone-4, benzophenone-8, titanium dioxide, and zinc oxide. In certain embodiments, the UV-A + UV-B broadband filter is bis-ethylhexyloxyphenol methoxyphenyl triazine.
Also provided is a UV filter composition comprising isoamyl p-methoxycinnamate, ethylhexyl triazone, octyl salicylate, butyl methoxydibenzoylmethane, and bis-ethylhexyl oxyphenol methoxyphenyl triazine.
Also provided is a UV filter composition consisting of: isoamyl p-methoxycinnamate, ethylhexyl triazone, octyl salicylate, butyl methoxydibenzoylmethane, and bis-ethylhexyl oxyphenol methoxyphenyl triazine.
Also provided is a UV filter composition comprising diethylhexylbutamido triazone, ethylhexyl triazone, octyl salicylate, butylmethoxydibenzoylmethane and bis-ethylhexyloxyphenol methoxyphenyl triazine.
Also provided is a UV filter composition consisting of: diethylhexylbutamido-triazone, ethylhexyl-triazone, octyl salicylate, butylmethoxydibenzoylmethane and bis-ethylhexyloxyphenol methoxyphenyl triazine.
Also provided is a UV filter composition comprising diethylhexylbutamido triazone, isoamyl p-methoxycinnamate, octyl salicylate, butyl methoxydibenzoylmethane, and bis-ethylhexyloxyphenol methoxyphenyl triazine.
Also provided is a UV filter composition consisting of: diethylhexylbutamido triazone, isoamyl p-methoxycinnamate, octyl salicylate, butylmethoxydibenzoylmethane, and bis-ethylhexyloxyphenol methoxyphenyl triazine.
Also provided is a sunscreen composition comprising a UV filter composition comprising isoamyl p-methoxycinnamate, ethylhexyl triazone, octyl salicylate, butyl methoxydibenzoylmethane, and bis-ethylhexyl oxyphenol methoxyphenyl triazine.
Also provided is a sunscreen composition comprising a UV filter composition comprising diethylhexylbutamido triazone, ethylhexyl triazone, octyl salicylate, butylmethoxydibenzoylmethane, and bis-ethylhexyloxyphenol methoxyphenyl triazine.
Also provided is a sunscreen composition comprising a UV filter composition comprising diethylhexylbutamido triazone, isoamyl p-methoxycinnamate, octyl salicylate, butylmethoxydibenzoylmethane, and bis-ethylhexyloxyphenol methoxyphenyl triazine.
In certain embodiments, the sunscreen composition does not include nanoparticles.
In certain embodiments, the sunscreen composition does not include benzophenone-3.
In certain embodiments, the sunscreen composition does not include octyl methoxycinnamate.
In certain embodiments, the composition does not include cinnamates other than isoamyl p-methoxycinnamate.
In certain embodiments, the sunscreen composition does not include 2-ethylhexyl 2-cyano-3, 3-diphenylacrylate.
In certain embodiments, the sunscreen composition does not include 2- (benzotriazol-2-yl) -4, 6-di-tert-butylphenol, 2, 4-di-tert-butyl-6- (5-chlorobenzotriazol-2-yl) phenol, 2- (benzotriazol-2-yl) -4, 6-bis- (1, 1-dimethylpropyl) -phenol, or 2- (benzotriazol-2-yl) -6-butane 2-yl-4-tert-butylphenol.
In certain embodiments, each of the UV filters in the sunscreen composition is present in an amount from about 0.1 w/w% to about 25 w/w%, from about 0.1 w/w% to about 20 w/w%, from about 0.1 w/w% to about 18 w/w%, from 0.1 w/w% to about 15 w/w%, from about 0.1 w/w% to about 12 w/w%, from about 0.1 w/w% to about 10 w/w%, from 0.1 w/w% to about 8 w/w%, from about 0.1 to about 6 w/w%, wherein weight percentages are based on the total weight of the sunscreen composition.
In certain embodiments, the sunscreen composition comprises less than about 35 w/w% UV filter. In certain embodiments, the sunscreen composition comprises between about 5 w/w% and about 25 w/w% of a UV filter. In certain embodiments, the sunscreen composition includes about 20 w/w% of the UV filter.
In certain embodiments, sunscreen compositions include the following: butyl methoxydibenzoylmethane as UV-A filter, ethylhexyl triazone as UV-B filter, octyl salicylate as UV-B filter, isoamyl p-methoxycinnamate as UV-B filter, and bis-ethylhexyl oxyphenol methoxyphenyl triazine as broadband UV-A and UV-B filters.
In certain embodiments, sunscreen compositions include the following: butyl methoxydibenzoylmethane as UV-A filter, ethylhexyl triazone as UV-B filter, octyl salicylate as UV-B filter, diethylhexyl butamido triazone as UV-B filter and bis-ethylhexyl oxyphenol methoxyphenyl triazine as broadband UV-A and UV-B filters.
In certain embodiments, sunscreen compositions include the following: butyl methoxydibenzoylmethane as UV-A filter, isoamyl p-methoxycinnamate as UV-B filter, octyl salicylate as UV-B filter, diethylhexyl butamido triazone as UV-B filter, and bis-ethylhexyloxyphenol methoxyphenyl triazine as broadband UV-A and UV-B filters.
In certain embodiments, sunscreen compositions include the following: butyl methoxydibenzoylmethane as UV-A filter, ethylhexyl triazone as UV-B filter, octyl salicylate as UV-B filter, isoamyl p-methoxycinnamate as UV-B filter and bis-ethylhexyl oxyphenol methoxyphenyl triazine as broadband UV-A and UV-B filters, wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 2: 7: 1.
In certain embodiments, sunscreen compositions include the following: a UV-A filter of butyl methoxydibenzoylmethane, a UV-B filter of ethylhexyl triazone, a UV-B filter of octyl salicylate, a UV-B filter of diethylhexyl butamido triazone and a broadband UV-A and UV-B filter of bis-ethylhexyloxyphenol methoxyphenyl triazine, wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 2: 5.5: 1.
In certain embodiments, sunscreen compositions include the following: butyl methoxydibenzoylmethane as UV-A filter, isoamyl p-methoxycinnamate as UV-B filter, octyl salicylate as UV-B filter, diethylhexyl butamido triazone as UV-B filter and bis-ethylhexyloxyphenol methoxyphenyl triazine as broadband UV-A and UV-B filters, wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 2: 7: 1.
In certain embodiments, sunscreen compositions include the following: butyl methoxydibenzoylmethane as UV-A filter, ethylhexyl triazone as UV-B filter, octyl salicylate as UV-B filter, isoamyl p-methoxycinnamate as UV-B filter and bis-ethylhexyl oxyphenol methoxyphenyl triazine as broadband UV-A and UV-B filters, wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 2: 7: 1.
In certain embodiments, sunscreen compositions include the following: a UV-A filter of butyl methoxydibenzoylmethane, a UV-B filter of ethylhexyl triazone, a UV-B filter of octyl salicylate, a UV-B filter of diethylhexyl butamido triazone and a broadband UV-A and UV-B filter of bis-ethylhexyloxyphenol methoxyphenyl triazine, wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 4: 11: 2.
In certain embodiments, sunscreen compositions include the following: butyl methoxydibenzoylmethane as UV-A filter, isoamyl p-methoxycinnamate as UV-B filter, octyl salicylate as UV-B filter, diethylhexyl butamido triazone as UV-B filter, and bis-ethylhexyloxyphenol methoxyphenyl triazine as broadband UV-A and UV-B filters, wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 1: 3: 1.
In certain embodiments, sunscreen compositions include the following: butyl methoxydibenzoylmethane as UV-A filter, ethylhexyl triazone as UV-B filter, octyl salicylate as UV-B filter, isoamyl p-methoxycinnamate as UV-B filter and bis-ethylhexyl oxyphenol methoxyphenyl triazine as broadband UV-A and UV-B filters, wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 4: 13: 2.
In certain embodiments, sunscreen compositions include the following: a UV-A filter of butyl methoxydibenzoylmethane, a UV-B filter of ethylhexyl triazone, a UV-B filter of octyl salicylate, a UV-B filter of diethylhexyl butamido triazone and a broadband UV-A and UV-B filter of bis-ethylhexyloxyphenol methoxyphenyl triazine, wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 4: 13: 2.
In certain embodiments, the sunscreen composition comprises the following: butyl methoxydibenzoylmethane as UV-A filter, isoamyl p-methoxycinnamate as UV-B filter, octyl salicylate as UV-B filter, diethylhexyl butamido triazone as UV-B filter and bis-ethylhexyloxyphenol methoxyphenyl triazine as broadband UV-A and UV-B filters, wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 4: 13: 2.
In certain embodiments, sunscreen compositions include the following: butyl methoxydibenzoylmethane as UV-A filter, ethylhexyl triazone as UV-B filter, octyl salicylate as UV-B filter, isoamyl p-methoxycinnamate as UV-B filter and bis-ethylhexyl oxyphenol methoxyphenyl triazine as broadband UV-A and UV-B filters, wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 6: 17: 6.
In certain embodiments, the sunscreen composition comprises the following: a UV-A filter of butyl methoxydibenzoylmethane, a UV-B filter of ethylhexyl triazone, a UV-B filter of octyl salicylate, a UV-B filter of diethylhexyl butamido triazone and a broadband UV-A and UV-B filter of bis-ethylhexyloxyphenol methoxyphenyl triazine, wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 6: 17: 4.
In certain embodiments, sunscreen compositions include the following: butyl methoxydibenzoylmethane as UV-A filter, isoamyl p-methoxycinnamate as UV-B filter, octyl salicylate as UV-B filter, diethylhexyl butamido triazone as UV-B filter and bis-ethylhexyloxyphenol methoxyphenyl triazine as broadband UV-A and UV-B filters, wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 6: 17: 6.
In certain embodiments, sunscreen compositions include the following: butyl methoxydibenzoylmethane as UV-A filter, ethylhexyl triazone as UV-B filter, octyl salicylate as UV-B filter, isoamyl p-methoxycinnamate as UV-B filter and bis-ethylhexyl oxyphenol methoxyphenyl triazine as broadband UV-A and UV-B filters, wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 7: 13: 6.
In certain embodiments, sunscreen compositions include the following: a UV-A filter of butyl methoxydibenzoylmethane, a UV-B filter of ethylhexyl triazone, a UV-B filter of octyl salicylate, a UV-B filter of diethylhexyl butamido triazone and a broadband UV-A and UV-B filter of bis-ethylhexyloxyphenol methoxyphenyl triazine, wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 6: 17: 4.
In certain embodiments, the sunscreen composition comprises the following: butyl methoxydibenzoylmethane as UV-A filter, isoamyl p-methoxycinnamate as UV-B filter, octyl salicylate as UV-B filter, diethylhexyl butamido triazone as UV-B filter and bis-ethylhexyloxyphenol methoxyphenyl triazine as broadband UV-A and UV-B filters, wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 7: 13: 6.
In certain embodiments, sunscreen compositions include the following: butyl methoxydibenzoylmethane as UV-A filter, ethylhexyl triazone as UV-B filter, octyl salicylate as UV-B filter, isoamyl p-methoxycinnamate as UV-B filter and bis-ethylhexyl oxyphenol methoxyphenyl triazine as broadband UV-A and UV-B filters, wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 1: 2: 1.
In certain embodiments, sunscreen compositions include the following: a UV-A filter of butyl methoxydibenzoylmethane, a UV-B filter of ethylhexyl triazone, a UV-B filter of octyl salicylate, a UV-B filter of diethylhexyl butamido triazone and a broadband UV-A and UV-B filter of bis-ethylhexyloxyphenol methoxyphenyl triazine, wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 3: 8.5: 2.
In certain embodiments, sunscreen compositions include the following: butyl methoxydibenzoylmethane as UV-A filter, isoamyl p-methoxycinnamate as UV-B filter, octyl salicylate as UV-B filter, diethylhexyl butamido triazone as UV-B filter, and bis-ethylhexyloxyphenol methoxyphenyl triazine as broadband UV-A and UV-B filters, wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 1: 2: 1.
In certain embodiments, sunscreen compositions include the following: butyl methoxydibenzoylmethane as UV-A filter, ethylhexyl triazone as UV-B filter, octyl salicylate as UV-B filter, isoamyl p-methoxycinnamate as UV-B filter and bis-ethylhexyl oxyphenol methoxyphenyl triazine as broadband UV-A and UV-B filters, wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 7: 11: 6.
In certain embodiments, sunscreen compositions include the following: a UV-A filter of butyl methoxydibenzoylmethane, a UV-B filter of ethylhexyl triazone, a UV-B filter of octyl salicylate, a UV-B filter of diethylhexyl butamido triazone and a broadband UV-A and UV-B filter of bis-ethylhexyloxyphenol methoxyphenyl triazine, wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 7: 11: 6.
In certain embodiments, sunscreen compositions include the following: butyl methoxydibenzoylmethane as UV-A filter, isoamyl p-methoxycinnamate as UV-B filter, octyl salicylate as UV-B filter, diethylhexyl butamido triazone as UV-B filter and bis-ethylhexyloxyphenol methoxyphenyl triazine as broadband UV-A and UV-B filters, wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 7: 11: 6.
In certain embodiments, sunscreen compositions include the following: butyl methoxydibenzoylmethane as UV-A filter, ethylhexyl triazone as UV-B filter, octyl salicylate as UV-B filter, isoamyl p-methoxycinnamate as UV-B filter and bis-ethylhexyl oxyphenol methoxyphenyl triazine as broadband UV-A and UV-B filters, wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 9: 24: 8.
In certain embodiments, sunscreen compositions include the following: butyl methoxydibenzoylmethane as UV-A filter, ethylhexyl triazone as UV-B filter, octyl salicylate as UV-B filter, diethylhexyl butamido triazone as UV-B filter and bis-ethylhexyl oxyphenol methoxyphenyl triazine as broadband UV-A and UV-B filters, the mass ratio of UV-A filter to UV-B filter to broadband filter being about 9: 20: 7.
In certain embodiments, sunscreen compositions include the following: butyl methoxydibenzoylmethane as UV-A filter, isoamyl p-methoxycinnamate as UV-B filter, octyl salicylate as UV-B filter, diethylhexyl butamido triazone as UV-B filter and bis-ethylhexyloxyphenol methoxyphenyl triazine as broadband UV-A and UV-B filters, wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 9: 24: 8.
In certain embodiments, sunscreen compositions include the following: butyl methoxydibenzoylmethane as UV-A filter, ethylhexyl triazone as UV-B filter, octyl salicylate as UV-B filter, isoamyl p-methoxycinnamate as UV-B filter and bis-ethylhexyl oxyphenol methoxyphenyl triazine as broadband UV-A and UV-B filters, wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 9: 19: 8.
In certain embodiments, sunscreen compositions include the following: a UV-A filter of butyl methoxydibenzoylmethane, a UV-B filter of ethylhexyl triazone, a UV-B filter of octyl salicylate, a UV-B filter of diethylhexyl butamido triazone and a broadband UV-A and UV-B filter of bis-ethylhexyloxyphenol methoxyphenyl triazine, wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 9: 19: 8.
In certain embodiments, the sunscreen composition comprises the following: butyl methoxydibenzoylmethane as UV-A filter, isoamyl p-methoxycinnamate as UV-B filter, octyl salicylate as UV-B filter, diethylhexyl butamido triazone as UV-B filter and bis-ethylhexyloxyphenol methoxyphenyl triazine as broadband UV-A and UV-B filters, wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 9: 19: 8.
In certain embodiments, sunscreen compositions include the following: butyl methoxydibenzoylmethane as UV-A filter, ethylhexyl triazone as UV-B filter, octyl salicylate as UV-B filter, isoamyl p-methoxycinnamate as UV-B filter, and bis-ethylhexyl oxyphenol methoxyphenyl triazine as broadband UV-A and UV-B filters, wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 9: 17: 8.
In certain embodiments, sunscreen compositions include the following: butyl methoxydibenzoylmethane as UV-A filter, ethylhexyl triazone as UV-B filter, octyl salicylate as UV-B filter, diethylhexyl butamido triazone as UV-B filter and bis-ethylhexyl oxyphenol methoxyphenyl triazine as broadband UV-A and UV-B filters, the mass ratio of UV-A filter to UV-B filter to broadband filter being about 9: 20: 7.
In certain embodiments, sunscreen compositions include the following: butyl methoxydibenzoylmethane as UV-A filter, isoamyl p-methoxycinnamate as UV-B filter, octyl salicylate as UV-B filter, diethylhexyl butamido triazone as UV-B filter and bis-ethylhexyloxyphenol methoxyphenyl triazine as broadband UV-A and UV-B filters, wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 9: 17: 8.
In certain embodiments, sunscreen compositions include the following: butyl methoxydibenzoylmethane as UV-A filter, ethylhexyl triazone as UV-B filter, octyl salicylate as UV-B filter, isoamyl p-methoxycinnamate as UV-B filter and bis-ethylhexyl oxyphenol methoxyphenyl triazine as broadband UV-A and UV-B filters, wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 9: 25: 7.
In certain embodiments, sunscreen compositions include the following: a UV-A filter of butyl methoxydibenzoylmethane, a UV-B filter of ethylhexyl triazone, a UV-B filter of octyl salicylate, a UV-B filter of diethylhexyl butamido triazone and a broadband UV-A and UV-B filter of bis-ethylhexyloxyphenol methoxyphenyl triazine, wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 9: 25: 7.
In certain embodiments, sunscreen compositions include the following: butyl methoxydibenzoylmethane as UV-A filter, isoamyl p-methoxycinnamate as UV-B filter, octyl salicylate as UV-B filter, diethylhexyl butamido triazone as UV-B filter and bis-ethylhexyloxyphenol methoxyphenyl triazine as broadband UV-A and UV-B filters, wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 9: 25: 7.
In certain embodiments, the sunscreen composition comprises the following: butyl methoxydibenzoylmethane as UV-A filter, ethylhexyl triazone as UV-B filter, octyl salicylate as UV-B filter, isoamyl p-methoxycinnamate as UV-B filter and bis-ethylhexyl oxyphenol methoxyphenyl triazine as broadband UV-A and UV-B filters, wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 9: 23: 8.
In certain embodiments, sunscreen compositions include the following: a UV-A filter of butyl methoxydibenzoylmethane, a UV-B filter of ethylhexyl triazone, a UV-B filter of octyl salicylate, a UV-B filter of diethylhexyl butamido triazone and a broadband UV-A and UV-B filter of bis-ethylhexyloxyphenol methoxyphenyl triazine, wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 9: 23: 8.
In certain embodiments, the sunscreen composition comprises the following: butyl methoxydibenzoylmethane as UV-A filter, isoamyl p-methoxycinnamate as UV-B filter, octyl salicylate as UV-B filter, diethylhexyl butamido triazone as UV-B filter, and bis-ethylhexyloxyphenol methoxyphenyl triazine as broadband UV-A and UV-B filters, wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 9: 23: 8.
In certain embodiments, sunscreen compositions include the following: butyl methoxydibenzoylmethane as UV-A filter, ethylhexyl triazone as UV-B filter, octyl salicylate as UV-B filter, isoamyl p-methoxycinnamate as UV-B filter and bis-ethylhexyl oxyphenol methoxyphenyl triazine as broadband UV-A and UV-B filters, wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 9: 18: 8.
In certain embodiments, sunscreen compositions include the following: butyl methoxydibenzoylmethane as UV-A filter, ethylhexyl triazone as UV-B filter, octyl salicylate as UV-B filter, diethylhexyl butamido triazone as UV-B filter and bis-ethylhexyl oxyphenol methoxyphenyl triazine as broadband UV-A and UV-B filters, the mass ratio of UV-A filter to UV-B filter to broadband filter being about 9: 20: 7.
In certain embodiments, sunscreen compositions include the following: butyl methoxydibenzoylmethane as UV-A filter, isoamyl p-methoxycinnamate as UV-B filter, octyl salicylate as UV-B filter, diethylhexyl butamido triazone as UV-B filter and bis-ethylhexyloxyphenol methoxyphenyl triazine as broadband UV-A and UV-B filters, wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 9: 18: 8.
In certain embodiments, sunscreen compositions include the following: butyl methoxydibenzoylmethane as UV-A filter, ethylhexyl triazone as UV-B filter, octyl salicylate as UV-B filter, isoamyl p-methoxycinnamate as UV-B filter and bis-ethylhexyl oxyphenol methoxyphenyl triazine as broadband UV-A and UV-B filters, wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 9: 18: 8.
In certain embodiments, sunscreen compositions include the following: butyl methoxydibenzoylmethane as UV-A filter, ethylhexyl triazone as UV-B filter, octyl salicylate as UV-B filter, diethylhexyl butamido triazone as UV-B filter and bis-ethylhexyl oxyphenol methoxyphenyl triazine as broadband UV-A and UV-B filters, the mass ratio of UV-A filter to UV-B filter to broadband filter being about 9: 20: 7.
In certain embodiments, sunscreen compositions include the following: butyl methoxydibenzoylmethane as UV-A filter, isoamyl p-methoxycinnamate as UV-B filter, octyl salicylate as UV-B filter, diethylhexyl butamido triazone as UV-B filter and bis-ethylhexyloxyphenol methoxyphenyl triazine as broadband UV-A and UV-B filters, wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 9: 18: 8.
In certain embodiments, sunscreen compositions include the following: butyl methoxydibenzoylmethane as UV-A filter, ethylhexyl triazone as UV-B filter, octyl salicylate as UV-B filter, isoamyl p-methoxycinnamate as UV-B filter and bis-ethylhexyl oxyphenol methoxyphenyl triazine as broadband UV-A and UV-B filters, wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 9: 15: 8.
In certain embodiments, sunscreen compositions include the following: a UV-A filter of butyl methoxydibenzoylmethane, a UV-B filter of ethylhexyl triazone, a UV-B filter of octyl salicylate, a UV-B filter of diethylhexyl butamido triazone and a broadband UV-A and UV-B filter of bis-ethylhexyloxyphenol methoxyphenyl triazine, wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 9: 14: 8.
In certain embodiments, sunscreen compositions include the following: butyl methoxydibenzoylmethane as UV-A filter, isoamyl p-methoxycinnamate as UV-B filter, octyl salicylate as UV-B filter, diethylhexyl butamido triazone as UV-B filter and bis-ethylhexyloxyphenol methoxyphenyl triazine as broadband UV-A and UV-B filters, wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 9: 15: 8.
In certain embodiments, sunscreen compositions include the following: butyl methoxydibenzoylmethane as UV-A filter, ethylhexyl triazone as UV-B filter, octyl salicylate as UV-B filter, isoamyl p-methoxycinnamate as UV-B filter, and bis-ethylhexyl oxyphenol methoxyphenyl triazine as broadband UV-A and UV-B filters, wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 9: 16: 8.
In certain embodiments, sunscreen compositions include the following: butyl methoxydibenzoylmethane as UV-A filter, ethylhexyl triazone as UV-B filter, octyl salicylate as UV-B filter, diethylhexyl butamido triazone as UV-B filter and bis-ethylhexyl oxyphenol methoxyphenyl triazine as broadband UV-A and UV-B filters, the mass ratio of UV-A filter to UV-B filter to broadband filter being about 9: 14: 8.
In certain embodiments, sunscreen compositions include the following: butyl methoxydibenzoylmethane as UV-A filter, isoamyl p-methoxycinnamate as UV-B filter, octyl salicylate as UV-B filter, diethylhexyl butamido triazone as UV-B filter and bis-ethylhexyloxyphenol methoxyphenyl triazine as broadband UV-A and UV-B filters, wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 9: 16: 8.
In certain embodiments, sunscreen compositions include the following: butyl methoxydibenzoylmethane as UV-A filter, ethylhexyl triazone as UV-B filter, octyl salicylate as UV-B filter, isoamyl p-methoxycinnamate as UV-B filter and bis-ethylhexyl oxyphenol methoxyphenyl triazine as broadband UV-A and UV-B filters, wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 9: 15: 8.
In certain embodiments, sunscreen compositions include the following: a UV-A filter of butyl methoxydibenzoylmethane, a UV-B filter of ethylhexyl triazone, a UV-B filter of octyl salicylate, a UV-B filter of diethylhexyl butamido triazone and a broadband UV-A and UV-B filter of bis-ethylhexyloxyphenol methoxyphenyl triazine, wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 9: 14: 8.
In certain embodiments, sunscreen compositions include the following: butyl methoxydibenzoylmethane as UV-A filter, isoamyl p-methoxycinnamate as UV-B filter, octyl salicylate as UV-B filter, diethylhexyl butamido triazone as UV-B filter and bis-ethylhexyloxyphenol methoxyphenyl triazine as broadband UV-A and UV-B filters, wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 9: 15: 8.
In certain embodiments, the ratio of UVA/UVB filters in the sunscreen composition is between about 0.6 and about 0.8. In certain embodiments, the ratio of UVA/UVB filters in the sunscreen composition is about 0.7.
In certain embodiments, the sunscreen composition has an average critical wavelength of about 370nm or greater. In certain embodiments, the sunscreen composition has an average critical wavelength of about 375 nm.
In certain embodiments, the sunscreen composition has an SPF of at least about 15, such as about 15. In certain embodiments, the composition has an SPF of at least about 30. In certain embodiments, the composition has an SPF of at least about 50. In certain embodiments, the composition has an SPF of at least about 60.
In certain embodiments, the sunscreen composition further comprises a solubilizing agent. In certain embodiments, the solubilizer acts to solubilize the UV filter. In certain embodiments, the solubilizing agent acts to prevent the formation of solid particles. In certain embodiments, sunscreen compositions include lower levels of solubilizing agents. In certain embodiments, the ratio of UV solubilizer to UV filter is between about 0.5 and about 2.3, such as 0.5, about 0.6, about 0.7, about 0.8, about 0.9, about 1, about 1.1, about 1.2, about 1.3, about 1.4, about 1.5, about 1.6, about 1.7, about 1.8, about 1.9, or about 2.0.
In certain embodiments, the sunscreen composition includes up to about 36 w/w% of a solubilizing agent. In certain embodiments, the sunscreen composition includes about 20 w/w% of a solubilizing agent. In certain embodiments, the sunscreen composition comprises less than about 20 w/w% of a solubilizing agent. In certain embodiments, the sunscreen composition comprises between about 15 w/w% and 20 w/w% of a solubilizing agent.
In certain embodiments, the sunscreen composition includes between about 0.1 w/w% to about 5 w/w% of a solubilizing agent. In certain embodiments, the sunscreen composition includes between about 0.1 w/w% to about 15 w/w% of a solubilizing agent. In certain embodiments, the sunscreen composition includes between about 0.1W/W% to about 25W/W% of a solubilizing agent. In certain embodiments, the sunscreen composition includes between about 0.1 w/w% to about 35 w/w% of a solubilizing agent.
In certain embodiments, the sunscreen composition comprises at least one solubilizing agent selected from the group consisting of: diisopropyl sebacate, dioctyl carbonate, decyl cocoate, diisopropyl adipate, isopropyl lauroyl sarcosinate, dibutyl adipate, butyl octyl salicylate, C12-15 alkyl benzoate, and diethyl ethylhexyl succinate. In certain embodiments, the sunscreen composition comprises at least one solubilizing agent selected from the group consisting of: diisopropyl sebacate, diisopropyl adipate, dioctyl carbonate, dibutyl adipate, butyl octyl salicylate, decyl cocoate, C12-15 alkyl benzoate, diethylhexyl succinate, diethylhexyl carbonate, and isopropyl lauroyl sarcosinate.
In certain embodiments, the sunscreen composition comprises two solubilizing agents selected from the group consisting of: diisopropyl sebacate, diisopropyl adipate, dioctyl carbonate, dibutyl adipate, butyl octyl salicylate, decyl cocoate, C12-15 alkyl benzoate, diethylhexyl succinate, diethylhexyl carbonate, and isopropyl lauroyl sarcosinate. In certain embodiments, the sunscreen composition comprises three solubilizing agents selected from the group consisting of: diisopropyl sebacate, diisopropyl adipate, dioctyl carbonate, dibutyl adipate, butyl octyl salicylate, decyl cocoate, C12-15 alkyl benzoate, diethylhexyl succinate, diethylhexyl carbonate, and isopropyl lauroyl sarcosinate.
In certain embodiments, the sunscreen composition comprises from 0.1 w/w% to 5 w/w% ethylhexyl salicylate and optionally at least one additional solubilizer.
In certain embodiments, the sunscreen composition comprises from 0.1 w/w% to 25 w/w% of at least one solubilizing agent selected from the group consisting of: dibutyl adipate, C12-15 alkyl benzoate, diethylhexyl succinate, diethylhexyl carbonate, and isopropyl lauroylsarcosine, and optionally at least one additional solubilizer.
In certain embodiments, the sunscreen composition comprises from 0.1 w/w% to 25 w/w% of at least one solubilizing agent selected from the group consisting of: diisopropyl sebacate, diisopropyl adipate, dioctyl carbonate and decyl cocoate and optionally at least one additional solubilizer.
In certain embodiments, a sunscreen composition comprises:
the UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter is ethylhexyl triazone;
the second UV-B light filter is octyl salicylate;
the third UV-B light filter is isoamyl p-methoxycinnamate; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 2: 7: 1, and
wherein the composition comprises the solubilizer diisopropyl sebacate, such as about 5% to about 9% diisopropyl sebacate, for example about 6% to about 8% diisopropyl sebacate.
In certain embodiments, a sunscreen composition comprises:
the UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter agent is ethylhexyl triazone;
the second UV-B light filter is octyl salicylate;
the third UV-B filter agent is diethyl hexyl butamido triazone; and is provided with
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of the UV-A filter agent to the UV-B filter agent to the broadband filter agent is about 2: 5.5: 1,
wherein the composition comprises the solubilizer diisopropyl sebacate, such as about 8% to 10% diisopropyl sebacate.
In certain embodiments, a sunscreen composition comprises:
the UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter agent is isoamyl p-methoxycinnamate;
the second UV-B light filter is octyl salicylate;
the third UV-B filter agent is diethyl hexyl butamido triazone; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 2: 7: 1, and
wherein the composition comprises the solubilizer diisopropyl sebacate, such as about 5% to about 9% diisopropyl sebacate, for example about 6% to about 8% diisopropyl sebacate.
In certain embodiments, a sunscreen composition comprises:
the UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter is ethylhexyl triazone;
the second UV-B light filter is octyl salicylate;
the third UV-B light filter is isoamyl p-methoxycinnamate; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 2: 7: 2, and
wherein the composition comprises the solubilizer diisopropyl sebacate, such as from about 5% to about 9% diisopropyl sebacate, for example from about 6% to about 8% diisopropyl sebacate.
In certain embodiments, a sunscreen composition comprises:
the UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter is ethylhexyl triazone;
the second UV-B light filter is octyl salicylate;
the third UV-B filter agent is diethyl hexyl butamido triazone; and is provided with
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 4: 11: 2, and
wherein the composition comprises the solubilizer dibutyl adipate, such as about 8% to about 11% dibutyl adipate, for example about 9% to about 10%.
In certain embodiments, a sunscreen composition comprises:
the UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter agent is isoamyl p-methoxycinnamate;
the second UV-B light filter is octyl salicylate;
the third UV-B filter agent is diethyl hexyl butamido triazone; and is provided with
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 1: 3: 1, and
wherein the composition comprises the solubilizer diisopropyl sebacate, such as about 5% to about 9% diisopropyl sebacate, for example about 6% to about 8% diisopropyl sebacate.
In certain embodiments, a sunscreen composition comprises:
the UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter agent is ethylhexyl triazone;
the second UV-B light filter is octyl salicylate;
the third UV-B light filter is isoamyl p-methoxycinnamate; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 4: 13: 2, and
wherein the composition comprises the solubilizer diisopropyl sebacate, such as about 5% to about 9% diisopropyl sebacate, for example about 6% to about 8% diisopropyl sebacate.
In certain embodiments, a sunscreen composition comprises:
the UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter agent is isoamyl p-methoxycinnamate;
the second UV-B light filter is octyl salicylate;
the third UV-B filter agent is diethyl hexyl butamido triazone; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 4: 13: 2, and
wherein the composition comprises the solubilizer diisopropyl sebacate, such as about 5% to about 9% diisopropyl sebacate, for example about 6% to about 8% diisopropyl sebacate.
In certain embodiments, a sunscreen composition comprises, wherein:
the UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter is ethylhexyl triazone;
the second UV-B filter agent is octyl salicylate;
the third UV-B light filter is isoamyl p-methoxycinnamate; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 6: 17: 4, and
wherein the composition further comprises diisopropyl sebacate and dioctyl carbonate, such as a mixture of diisopropyl sebacate and dioctyl carbonate from about 13% to about 15.5%, for example a mixture of diisopropyl sebacate and dioctyl carbonate from about 13.5% to about 15%.
In certain embodiments, a sunscreen composition comprises:
the UV-A light filtering agent is butyl methoxy dibenzoyl methane;
the first UV-B filter is ethylhexyl triazone;
the second UV-B light filter is octyl salicylate;
the third UV-B filter agent is diethyl hexyl butamido triazone; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 6: 17: 4, and
wherein the composition further comprises diisopropyl sebacate and dioctyl carbonate, such as a mixture of diisopropyl sebacate and dioctyl carbonate from about 13% to about 15.5%, for example a mixture of diisopropyl sebacate and dioctyl carbonate from about 13.5% to about 15%.
In certain embodiments, a sunscreen composition comprises:
the UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter agent is isoamyl p-methoxycinnamate;
the second UV-B light filter is octyl salicylate;
the third UV-B filter agent is diethyl hexyl butamido triazone; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 6: 17: 4, and
wherein the composition further comprises diisopropyl sebacate and dioctyl carbonate, such as a mixture of diisopropyl sebacate and dioctyl carbonate from about 13% to about 15.5%, for example a mixture of diisopropyl sebacate and dioctyl carbonate from about 13.5% to about 15%.
In certain embodiments, a sunscreen composition comprises:
the UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter is ethylhexyl triazone;
the second UV-B light filter is octyl salicylate;
the third UV-B light filter is isoamyl p-methoxycinnamate; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 7: 17: 6, and
wherein the composition further comprises decyl cocoate, isopropyl lauroyl sarcosinate, and dibutyl adipate, such as about 18% to about 20% decyl cocoate, a mixture of isopropyl lauroyl sarcosinate and dibutyl adipate, for example, about from about 18.5% to about 19.5% decyl cocoate, isopropyl lauroyl sarcosinate, and dibutyl adipate.
In certain embodiments, a sunscreen composition comprises:
the UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter is ethylhexyl triazone;
the second UV-B light filter is octyl salicylate;
the third UV-B filter agent is diethyl hexyl butamido triazone; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 6: 17: 4, and
wherein the composition further comprises decyl cocoate, isopropyl lauroyl sarcosinate, and dibutyl adipate, such as about 18% to about 20% decyl cocoate, a mixture of isopropyl lauroyl sarcosinate and dibutyl adipate, for example, about from about 18.5% to about 19.5% decyl cocoate, isopropyl lauroyl sarcosinate, and dibutyl adipate.
In certain embodiments, a sunscreen composition comprises:
the UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter agent is isoamyl p-methoxycinnamate;
the second UV-B light filter is octyl salicylate;
the third UV-B filter agent is diethyl hexyl butamido triazone; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 7: 13: 6, and
wherein the composition further comprises decyl cocoate, isopropyl lauroyl sarcosinate, and dibutyl adipate, such as about 16% to about 18% decyl cocoate, a mixture of isopropyl lauroyl sarcosinate and dibutyl adipate, for example about 16.5% to about 17.5% decyl cocoate, a mixture of isopropyl lauroyl sarcosinate and dibutyl adipate.
In certain embodiments, a sunscreen composition comprises:
the UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter is ethylhexyl triazone;
the second UV-B light filter is octyl salicylate;
the third UV-B filter agent is isoamyl p-methoxycinnamate; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 1: 2: 1, and
wherein the composition further comprises decyl cocoate and diisopropyl sebacate, such as a mixture of about 19% to about 21% decyl cocoate and diisopropyl sebacate, for example, a mixture of about 19.5% to about 20.5% decyl cocoate and diisopropyl sebacate.
In certain embodiments, a sunscreen composition comprises, wherein:
the UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter is ethylhexyl triazone;
the second UV-B light filter is octyl salicylate;
the third UV-B filter agent is diethyl hexyl butamido triazone; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 3: 8.5: 2, and
wherein the composition further comprises decyl cocoate and diisopropyl sebacate, such as a mixture of about 19% to about 21% decyl cocoate and diisopropyl sebacate, for example, a mixture of about 19.5% to about 20.5% decyl cocoate and diisopropyl sebacate.
In certain embodiments, a sunscreen composition comprises:
the UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter agent is isoamyl p-methoxycinnamate;
the second UV-B light filter is octyl salicylate;
the third UV-B filter agent is diethyl hexyl butamido triazone; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 1: 2: 1, and
wherein the composition further comprises decyl cocoate and diisopropyl sebacate, such as a mixture of about 19% to about 21% decyl cocoate and diisopropyl sebacate, for example, a mixture of about 19.5% to about 20.5% decyl cocoate and diisopropyl sebacate.
In certain embodiments, a sunscreen composition comprises, wherein:
the UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter is ethylhexyl triazone;
the second UV-B filter agent is octyl salicylate;
the third UV-B light filter is isoamyl p-methoxycinnamate; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
w wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 7: 11: 6, and
wherein the composition further comprises diisopropyl sebacate, dioctyl carbonate, and decyl cocoate, such as about 19.5% to about 21.5% diisopropyl sebacate, a mixture of dioctyl carbonate and decyl cocoate, for example, about 20% to about 21% diisopropyl sebacate, a mixture of dioctyl carbonate and decyl cocoate.
In certain embodiments, a sunscreen composition comprises, wherein:
the UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter is ethylhexyl triazone;
the second UV-B light filter is octyl salicylate;
the third UV-B filter agent is diethyl hexyl butamido triazone; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 6: 17: 4, and
wherein the composition further comprises diisopropyl sebacate, dioctyl carbonate, and decyl cocoate, such as about 19.5% to about 21.5% diisopropyl sebacate, a mixture of dioctyl carbonate and decyl cocoate, for example, about 20% to about 21% diisopropyl sebacate, a mixture of dioctyl carbonate and decyl cocoate.
In certain embodiments, a sunscreen composition comprises:
the UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter agent is isoamyl p-methoxycinnamate;
the second UV-B light filter is octyl salicylate;
the third UV-B filter agent is diethyl hexyl butamido triazone; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 7: 11: 6, and
wherein the composition further comprises diisopropyl sebacate, dioctyl carbonate, and decyl cocoate, such as about 19.5% to about 21.5% diisopropyl sebacate, a mixture of dioctyl carbonate and decyl cocoate, for example, about 20% to about 21% diisopropyl sebacate, a mixture of dioctyl carbonate and decyl cocoate.
In certain embodiments, a sunscreen composition comprises:
the UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter is ethylhexyl triazone;
the second UV-B light filter is octyl salicylate;
the third UV-B light filter is isoamyl p-methoxycinnamate; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 6: 17: 4, and
wherein the composition further comprises diisopropyl sebacate, decyl cocoate, and isopropyl lauroyl sarcosinate, such as about 16% to about 18% of diisopropyl sebacate, a mixture of decyl cocoate and isopropyl lauroyl sarcosinate, for example, about 16.5% to about 17.5% of diisopropyl sebacate, a mixture of decyl cocoate and isopropyl lauroyl sarcosinate.
In certain embodiments, a sunscreen composition comprises:
the UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter is ethylhexyl triazone;
the second UV-B light filter is octyl salicylate;
the third UV-B filter agent is diethyl hexyl butamido triazone; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 6: 17: 4, and
wherein the composition further comprises diisopropyl sebacate, decyl cocoate, and isopropyl lauroyl sarcosinate, such as about 16% to about 18% diisopropyl sebacate, a mixture of decyl cocoate and isopropyl lauroyl sarcosinate, for example, about 16.5% to about 17.5% diisopropyl sebacate, a mixture of decyl cocoate and isopropyl lauroyl sarcosinate.
In certain embodiments, a sunscreen composition comprises:
the UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter agent is isoamyl p-methoxycinnamate;
the second UV-B light filter is octyl salicylate;
the third UV-B filter agent is diethyl hexyl butamido triazone; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 7: 11: 6, and
wherein the composition further comprises diisopropyl sebacate, decyl cocoate, and isopropyl lauroyl sarcosinate, such as about 16% to about 18% diisopropyl sebacate, a mixture of decyl cocoate and isopropyl lauroyl sarcosinate, for example, about 16.5% to about 17.5% diisopropyl sebacate, a mixture of decyl cocoate and isopropyl lauroyl sarcosinate.
In certain embodiments, a sunscreen composition comprises:
the UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter is ethylhexyl triazone;
the second UV-B light filter is octyl salicylate;
the third UV-B light filter is isoamyl p-methoxycinnamate; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 9: 24: 8, and
wherein the composition further comprises diisopropyl sebacate, dioctyl carbonate, and decyl cocoate, such as about 18% to about 22% diisopropyl sebacate, a mixture of dioctyl carbonate and decyl cocoate, for example, about 19% to about 21% diisopropyl sebacate, a mixture of dioctyl carbonate and decyl cocoate.
In certain embodiments, a sunscreen composition comprises:
the UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter is ethylhexyl triazone;
the second UV-B light filter is octyl salicylate;
the third UV-B filter agent is diethyl hexyl butamido triazone; and is provided with
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 9: 20: 7, and
wherein the composition further comprises diisopropyl sebacate, dioctyl carbonate, and decyl cocoate, such as about 25% to about 29% diisopropyl sebacate, a mixture of dioctyl carbonate and decyl cocoate, for example, about 26% to about 28% diisopropyl sebacate, a mixture of dioctyl carbonate and decyl cocoate.
In certain embodiments, a sunscreen composition comprises:
the UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter agent is isoamyl p-methoxycinnamate;
the second UV-B light filter is octyl salicylate;
the third UV-B filter agent is diethyl hexyl butamido triazone; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 9: 24: 8, and
wherein the composition further comprises diisopropyl sebacate, dioctyl carbonate, and decyl cocoate, such as about 25% to about 29% diisopropyl sebacate, a mixture of dioctyl carbonate and decyl cocoate, for example, about 26% to about 28% diisopropyl sebacate, a mixture of dioctyl carbonate and decyl cocoate.
In certain embodiments, a sunscreen composition comprises:
the UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter agent is ethylhexyl triazone;
the second UV-B light filter is octyl salicylate;
the third UV-B light filter is isoamyl p-methoxycinnamate; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 9: 24: 8, and
wherein the composition further comprises diisopropyl sebacate and diisopropyl adipate, such as about 32.5% to about 35.5% of a mixture of diisopropyl sebacate and diisopropyl adipate, for example about 33% to about 35% of a mixture of diisopropyl sebacate and diisopropyl adipate.
In certain embodiments, a sunscreen composition comprises:
the UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter is ethylhexyl triazone;
the second UV-B filter agent is octyl salicylate;
the third UV-B filter agent is diethyl hexyl butamido triazone; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of the UV-A filter to the UV-B filter to the broadband filter is 9: 20: 7, and
wherein the composition further comprises diisopropyl sebacate and diisopropyl adipate, such as about 32.5% to about 35.5% of a mixture of diisopropyl sebacate and diisopropyl adipate, for example about 33% to about 35% of a mixture of diisopropyl sebacate and diisopropyl adipate.
In certain embodiments, a sunscreen composition comprises:
the UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter agent is isoamyl p-methoxycinnamate;
the second UV-B light filter is octyl salicylate;
the third UV-B filter agent is diethyl hexyl butamido triazone; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 9: 24: 8, and
wherein the composition further comprises diisopropyl sebacate and diisopropyl adipate, such as about 32.5% to about 35.5% of a mixture of diisopropyl sebacate and diisopropyl adipate, for example about 33% to about 35% of a mixture of diisopropyl sebacate and diisopropyl adipate.
In certain embodiments, a sunscreen composition comprises:
the UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter is ethylhexyl triazone;
the second UV-B filter agent is octyl salicylate;
the third UV-B light filter is isoamyl p-methoxycinnamate; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 9: 24: 8, and
wherein the composition further comprises diisopropyl sebacate, decyl cocoate, and isopropyl lauroyl sarcosinate, such as about 22.5% to about 25.5% diisopropyl sebacate, a mixture of decyl cocoate and isopropyl lauroyl sarcosinate, for example about 23% to 25% diisopropyl sebacate, a mixture of decyl cocoate and isopropyl lauroyl sarcosinate.
In certain embodiments, a sunscreen composition comprises:
the UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter is ethylhexyl triazone;
the second UV-B light filter is octyl salicylate;
the third UV-B filter agent is diethyl hexyl butamido triazone; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of the UV-A filter to the UV-B filter to the broadband filter is about 9: the ratio of the raw materials to the mixed materials is 20: 7,
wherein the composition further comprises diisopropyl sebacate, decyl cocoate, and isopropyl lauroyl sarcosinate, such as about 22.5% to about 25.5% diisopropyl sebacate, a mixture of decyl cocoate and isopropyl lauroyl sarcosinate, for example about 23% to 25% diisopropyl sebacate, a mixture of decyl cocoate and isopropyl lauroyl sarcosinate.
In certain embodiments, a sunscreen composition comprises:
the UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter agent is isoamyl p-methoxycinnamate;
the second UV-B filter agent is octyl salicylate;
the third UV-B filter agent is diethyl hexyl butamido triazone; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 9: 24: 8, and
wherein the composition further comprises diisopropyl sebacate, decyl cocoate, and isopropyl lauroyl sarcosinate, such as about 22.5% to about 25.5% diisopropyl sebacate, a mixture of decyl cocoate and isopropyl lauroyl sarcosinate, for example about 23% to 25% diisopropyl sebacate, a mixture of decyl cocoate and isopropyl lauroyl sarcosinate.
In certain embodiments, a sunscreen composition comprises:
the UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter agent is ethylhexyl triazone;
the second UV-B light filter is octyl salicylate;
the third UV-B light filter is isoamyl p-methoxycinnamate; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 9: 24: 8, and
wherein the composition further comprises decyl cocoate, isopropyl lauroyl sarcosinate, and dibutyl adipate, such as about 28% to about 31% decyl cocoate, a mixture of isopropyl lauroyl sarcosinate and dibutyl adipate, for example about 29% to about 30% decyl cocoate, isopropyl lauroyl sarcosinate, and dibutyl adipate.
In certain embodiments, a sunscreen composition comprises:
the UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter is ethylhexyl triazone;
the second UV-B filter agent is octyl salicylate;
the third UV-B filter agent is diethyl hexyl butamido triazone; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 9: 20: 7, and
wherein the composition further comprises decyl cocoate, isopropyl lauroyl sarcosinate, and dibutyl adipate, such as about 28% to about 31% decyl cocoate, a mixture of isopropyl lauroyl sarcosinate and dibutyl adipate, for example about 29% to about 30% decyl cocoate, isopropyl lauroyl sarcosinate, and dibutyl adipate.
In certain embodiments, a sunscreen composition comprises:
the UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter agent is isoamyl p-methoxycinnamate;
the second UV-B light filter is octyl salicylate;
the third UV-B filter agent is diethyl hexyl butamido triazone; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 9: 24: 8, and
wherein the composition further comprises decyl cocoate, isopropyl lauroyl sarcosinate, and dibutyl adipate, such as about 28% to about 31% decyl cocoate, a mixture of isopropyl lauroyl sarcosinate and dibutyl adipate, for example about 29% to about 30% decyl cocoate, a mixture of isopropyl lauroyl sarcosinate and dibutyl adipate.
In certain embodiments, a sunscreen composition comprises:
the UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter is ethylhexyl triazone;
the second UV-B light filter is octyl salicylate;
the third UV-B light filter is isoamyl p-methoxycinnamate; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 9: 19: 8, and
wherein the composition further comprises diisopropyl sebacate, decyl cocooleate, and isopropyl lauroyl sarcosinate, such as about 18% to about 22% diisopropyl sebacate, a mixture of decyl cocooleate and isopropyl lauroyl sarcosinate, for example, about 20% to about 21% diisopropyl sebacate, a mixture of decyl cocooleate and isopropyl lauroyl sarcosinate.
In certain embodiments, a sunscreen composition comprises:
the UV-A light filtering agent is butyl methoxy dibenzoyl methane;
the first UV-B filter agent is isoamyl p-methoxycinnamate;
the second UV-B filter agent is octyl salicylate;
the third UV-B filter agent is diethyl hexyl butamido triazone; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 9: 19: 8, and
wherein the composition further comprises diisopropyl sebacate, decyl cocooleate, and isopropyl lauroyl sarcosinate, such as about 18% to about 22% diisopropyl sebacate, a mixture of decyl cocooleate and isopropyl lauroyl sarcosinate, for example, about 20% to about 21% diisopropyl sebacate, a mixture of decyl cocooleate and isopropyl lauroyl sarcosinate.
In certain embodiments, a sunscreen composition comprises:
the UV-A light filtering agent is butyl methoxy dibenzoyl methane;
the first UV-B filter is ethylhexyl triazone;
the second UV-B filter agent is octyl salicylate;
the third UV-B light filter is isoamyl p-methoxycinnamate; and is provided with
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 9: 19: 8, and
wherein the composition further comprises diisopropyl sebacate, diisopropyl adipate, and decyl cocoate, such as about 29% to about 33% diisopropyl sebacate, a mixture of diisopropyl adipate and decyl cocoate, for example about 30% to about 32% diisopropyl sebacate, a mixture of diisopropyl adipate and decyl cocoate.
In certain embodiments, a sunscreen composition comprises:
the UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter agent is isoamyl p-methoxycinnamate;
the second UV-B light filter is octyl salicylate;
the third UV-B filter agent is diethyl hexyl butamido triazone; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 9: 19: 8, and
wherein the composition further comprises diisopropyl sebacate, diisopropyl adipate, and decyl cocoate, such as about 29% to about 33% diisopropyl sebacate, a mixture of diisopropyl adipate and decyl cocoate, for example about 30% to about 32% diisopropyl sebacate, a mixture of diisopropyl adipate and decyl cocoate.
In certain embodiments, a sunscreen composition comprises:
the UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter agent is ethylhexyl triazone;
the second UV-B light filter is octyl salicylate;
the third UV-B light filter is isoamyl p-methoxycinnamate; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 9: 17: 8, and
wherein the composition further comprises diisopropyl sebacate, diisopropyl adipate, and decyl cocoate, such as about 25% to about 28% diisopropyl sebacate, a mixture of diisopropyl adipate and decyl cocoate, for example, about 26% to about 27% diisopropyl sebacate, a mixture of diisopropyl adipate and decyl cocoate.
In certain embodiments, a sunscreen composition comprises:
the UV-A light filtering agent is butyl methoxy dibenzoyl methane;
the first UV-B filter is ethylhexyl triazone;
the second UV-B filter agent is octyl salicylate;
the third UV-B filter agent is diethyl hexyl butamido triazone; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 9: 20: 7, and
wherein the composition further comprises diisopropyl sebacate, diisopropyl adipate, and decyl cocoate, such as about 25% to about 28% diisopropyl sebacate, a mixture of diisopropyl adipate and decyl cocoate, for example, about 26% to about 27% diisopropyl sebacate, a mixture of diisopropyl adipate and decyl cocoate.
In certain embodiments, a sunscreen composition comprises:
the UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter agent is isoamyl p-methoxycinnamate;
the second UV-B light filter is octyl salicylate;
the third UV-B filter agent is diethyl hexyl butamido triazone; and is provided with
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 9: 17: 8, and
wherein the composition further comprises diisopropyl sebacate, diisopropyl adipate, and decyl cocoate, such as about 25% to about 28% diisopropyl sebacate, a mixture of diisopropyl adipate and decyl cocoate, for example, about 26% to about 27% diisopropyl sebacate, a mixture of diisopropyl adipate and decyl cocoate.
In certain embodiments, a sunscreen composition comprises:
the UV-A light filtering agent is butyl methoxy dibenzoyl methane;
the first UV-B filter is ethylhexyl triazone;
the second UV-B filter agent is octyl salicylate;
the third UV-B light filter is isoamyl p-methoxycinnamate; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 9: 25: 7, and
wherein the composition further comprises diisopropyl sebacate and dioctyl carbonate, such as a mixture of about 17% to about 20% diisopropyl sebacate and dioctyl carbonate, for example a mixture of about 18% to about 19% diisopropyl sebacate and dioctyl carbonate.
In certain embodiments, a sunscreen composition comprises:
the UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter agent is isoamyl p-methoxycinnamate;
the second UV-B filter agent is octyl salicylate;
the third UV-B filter agent is diethyl hexyl butamido triazone; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 9: 25: 7, and
wherein the composition further comprises diisopropyl sebacate and dioctyl carbonate, such as a mixture of diisopropyl sebacate and dioctyl carbonate from about 17% to about 20%, for example a mixture of diisopropyl sebacate and dioctyl carbonate from about 18% to about 19%.
In certain embodiments, a sunscreen composition comprises:
the UV-A light filtering agent is butyl methoxy dibenzoyl methane;
the first UV-B filter is ethylhexyl triazone;
the second UV-B light filter is octyl salicylate;
the third UV-B filter agent is isoamyl p-methoxycinnamate; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 9: 23: 8, and
wherein the composition further comprises diisopropyl sebacate, dioctyl carbonate, and decyl cocoate, such as about 20% to about 23% diisopropyl sebacate, a mixture of dioctyl carbonate and decyl cocoate, for example, about 21% to about 22% diisopropyl sebacate, a mixture of dioctyl carbonate and decyl cocoate.
In certain embodiments, a sunscreen composition comprises:
the UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter agent is isoamyl p-methoxycinnamate;
the second UV-B light filter is octyl salicylate;
the third UV-B filter agent is diethyl hexyl butamido triazone; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 9: 23: 8, and
wherein the composition further comprises diisopropyl sebacate, dioctyl carbonate, and decyl cocoate, such as about 20% to about 23% diisopropyl sebacate, a mixture of dioctyl carbonate and decyl cocoate, for example, about 21% to about 22% diisopropyl sebacate, a mixture of dioctyl carbonate and decyl cocoate.
In certain embodiments, a sunscreen composition comprises:
the UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter agent is ethylhexyl triazone;
the second UV-B light filter is octyl salicylate;
the third UV-B light filter is isoamyl p-methoxycinnamate; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 9: 18: 8, and
wherein the composition further comprises diisopropyl sebacate, dioctyl carbonate, and decyl cocoate, such as about 24% to about 28% diisopropyl sebacate, a mixture of dioctyl carbonate and decyl cocoate, for example, about 25% to about 27% diisopropyl sebacate, a mixture of dioctyl carbonate and decyl cocoate.
In certain embodiments, a sunscreen composition comprises:
the UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter agent is isoamyl p-methoxycinnamate;
the second UV-B light filter is octyl salicylate;
the third UV-B filter agent is diethyl hexyl butamido triazone; and is provided with
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 9: 18: 8, and
wherein the composition further comprises diisopropyl sebacate, dioctyl carbonate, and decyl cocoate, such as about 24% to about 28% diisopropyl sebacate, a mixture of dioctyl carbonate and decyl cocoate, for example, about 25% to about 27% diisopropyl sebacate, a mixture of dioctyl carbonate and decyl cocoate.
In certain embodiments, a sunscreen composition comprises:
the UV-A light filtering agent is butyl methoxy dibenzoyl methane;
the first UV-B filter is ethylhexyl triazone;
the second UV-B light filter is octyl salicylate;
the third UV-B filter agent is isoamyl p-methoxycinnamate; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 9: 18: 8, and
wherein the composition further comprises diisopropyl sebacate, dioctyl carbonate, and decyl cocoate, such as about 23% to about 26% diisopropyl sebacate, a mixture of dioctyl carbonate and decyl cocoate, for example, about 24% to about 25% diisopropyl sebacate, a mixture of dioctyl carbonate and decyl cocoate.
In certain embodiments, a sunscreen composition comprises:
the UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter is ethylhexyl triazone;
the second UV-B light filter is octyl salicylate;
the third UV-B filter agent is diethyl hexyl butamido triazone; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 9: 20: 7, and
wherein the composition further comprises dibutyl adipate and decyl cocoate, such as about 31% to about 34% of a mixture of dibutyl adipate and decyl cocoate, for example, about 32% to about 33% of a mixture of dibutyl adipate and decyl cocoate.
In certain embodiments, a sunscreen composition comprises:
the UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter agent is isoamyl p-methoxycinnamate;
the second UV-B filter agent is octyl salicylate;
the third UV-B filter agent is diethyl hexyl butamido triazone; and is provided with
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 9: 18: 8, and
wherein the composition further comprises diisopropyl sebacate, dioctyl carbonate, and decyl cocoate, such as about 23% to about 26% diisopropyl sebacate, a mixture of dioctyl carbonate and decyl cocoate, for example, about 24% to about 25% diisopropyl sebacate, a mixture of dioctyl carbonate and decyl cocoate.
In certain embodiments, a sunscreen composition comprises:
the UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter is ethylhexyl triazone;
the second UV-B light filter is octyl salicylate;
the third UV-B light filter is isoamyl p-methoxycinnamate; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 9: 18: 8, and
wherein the composition further comprises diisopropyl sebacate, decyl cocoate, and diisopropyl adipate, such as about 25% to about 28% diisopropyl sebacate, a mixture of decyl cocoate and diisopropyl adipate, for example, about 26% to about 27% diisopropyl sebacate, a mixture of decyl cocoate and diisopropyl adipate.
In certain embodiments, a sunscreen composition comprises:
the UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter agent is isoamyl p-methoxycinnamate;
the second UV-B light filter is octyl salicylate;
the third UV-B filter agent is diethyl hexyl butamido triazone; and is provided with
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 9: 18: 8, and
wherein the composition further comprises diisopropyl sebacate, decyl cocoate, and diisopropyl adipate, such as about 25% to about 28% diisopropyl sebacate, a mixture of decyl cocoate and diisopropyl adipate, for example, about 26% to about 27% diisopropyl sebacate, a mixture of decyl cocoate and diisopropyl adipate.
In certain embodiments, a sunscreen composition comprises:
the UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter is ethylhexyl triazone;
the second UV-B light filter is octyl salicylate;
the third UV-B light filter is isoamyl p-methoxycinnamate; and is provided with
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 9: 16: 8, and
wherein the composition further comprises diisopropyl sebacate, dioctyl carbonate, and decyl cocoate, such as about 24% to about 27% diisopropyl sebacate, a mixture of dioctyl carbonate and decyl cocoate, for example, about 25% to about 26% diisopropyl sebacate, a mixture of dioctyl carbonate and decyl cocoate.
In certain embodiments, a sunscreen composition comprises:
the UV-A light filtering agent is butyl methoxy dibenzoyl methane;
the first UV-B filter agent is ethylhexyl triazone;
the second UV-B light filter is octyl salicylate;
the third UV-B filter agent is diethyl hexyl butamido triazone; and is provided with
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 9: 14: 8, and
wherein the composition further comprises dibutyl adipate, such as about 36% to about 39% dibutyl adipate, for example about 37% to about 38% dibutyl adipate.
In certain embodiments, a sunscreen composition comprises:
the UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter agent is isoamyl p-methoxycinnamate;
the second UV-B light filter is octyl salicylate;
the third UV-B filter agent is diethyl hexyl butamido triazone; and is provided with
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 9: 16: 8, and
wherein the composition further comprises diisopropyl sebacate, dioctyl carbonate, and decyl cocoate, such as about 24% to about 27% diisopropyl sebacate, a mixture of dioctyl carbonate and decyl cocoate, for example, about 25% to about 26% diisopropyl sebacate, a mixture of dioctyl carbonate and decyl cocoate.
In certain embodiments, a sunscreen composition comprises:
the UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter is ethylhexyl triazone;
the second UV-B light filter is octyl salicylate;
the third UV-B light filter is isoamyl p-methoxycinnamate; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 9: 16: 8, and
wherein the composition further comprises diisopropyl sebacate, dioctyl carbonate, and decyl cocoate, such as about 25% to about 28% diisopropyl sebacate, a mixture of dioctyl carbonate and decyl cocoate, for example, about 26% to about 27% diisopropyl sebacate, a mixture of dioctyl carbonate and decyl cocoate.
In certain embodiments, a sunscreen composition comprises:
the UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter agent is ethylhexyl triazone;
the second UV-B light filter is octyl salicylate;
the third UV-B filter agent is diethyl hexyl butamido triazone; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 9: 14: 8, and
wherein the composition further comprises dibutyl adipate and decyl cocoate, such as about 31% to about 34% of a mixture of dibutyl adipate and decyl cocoate, for example, about 32% to about 33% of a mixture of dibutyl adipate and decyl cocoate.
In certain embodiments, a sunscreen composition comprises:
the UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter agent is isoamyl p-methoxycinnamate;
the second UV-B filter agent is octyl salicylate;
the third UV-B filter agent is diethyl hexyl butamido triazone; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 9: 15: 8, and
wherein the composition further comprises diisopropyl sebacate, dioctyl carbonate, and decyl cocoate, such as about 25% to about 28% diisopropyl sebacate, a mixture of dioctyl carbonate and decyl cocoate, for example, about 26% to about 27% diisopropyl sebacate, a mixture of dioctyl carbonate and decyl cocoate.
In certain embodiments, the sunscreen composition is an emulsion. In certain embodiments, the composition is an oil-in-water emulsion. In certain embodiments, the composition is a water-in-oil emulsion. In certain embodiments, the sunscreen composition is a spray. In certain embodiments, the sunscreen composition is an oil. In certain embodiments, the sunscreen composition is a lotion. In certain embodiments, the sunscreen composition is a cream. In certain embodiments, the sunscreen composition is a gel. In certain embodiments, the sunscreen composition is a butter. In certain embodiments, the sunscreen composition is a paste. In certain embodiments, the sunscreen composition is an ointment. In certain embodiments, the sunscreen composition is a stick. In certain embodiments, the sunscreen composition is a powder. In certain embodiments, the sunscreen composition is a wipe. In certain embodiments, the sunscreen composition is a towel. In certain embodiments, the sunscreen composition is a body wash. In certain embodiments, the sunscreen composition is a shampoo. In certain embodiments, the sunscreen composition is an aerosol. In certain embodiments, the sunscreen composition is a pour-on compact. In certain embodiments, the sunscreen composition is a solution. In certain embodiments, the sunscreen composition is an ointment. In certain embodiments, the sunscreen composition is a liquid. In certain embodiments, the sunscreen composition is a solid. In certain embodiments, the sunscreen composition is an emulsion. In certain embodiments, the sunscreen composition is a suspension. In certain embodiments, the sunscreen composition is a microemulsion. In certain embodiments, the sunscreen composition is a dispersant. In certain embodiments, the sunscreen composition is a microencapsulated product. In certain embodiments, the sunscreen composition is an ointment. In certain embodiments, the sunscreen composition is a supplement. In certain embodiments, the sunscreen composition is a paste. In certain embodiments, the sunscreen composition is a skin agent. In certain embodiments, the sunscreen composition is a soap. In certain embodiments, the sunscreen composition is an aerosol. In certain embodiments, the sunscreen composition is a mousse. In certain embodiments, the sunscreen composition is a wax. In certain embodiments, the sunscreen composition is a hair cream. In certain embodiments, the sunscreen composition is a spray (spritz). In certain embodiments, the sunscreen composition is a fake lacquer. In certain embodiments, the sunscreen composition is serum. In certain embodiments, the sunscreen composition is a powder. In certain embodiments, the sunscreen composition is a pencil. In certain embodiments, the sunscreen composition is a blusher. In certain embodiments, the sunscreen composition is high gloss. In certain embodiments, the sunscreen composition is a face-lift powder. In certain embodiments, the sunscreen composition is a concealer.
The vehicle may comprise an aqueous phase, an oil phase, an alcohol, a silicone phase, or mixtures thereof. Cosmetically acceptable vehicles may also include emulsions. Non-limiting examples of suitable emulsions include water-in-oil emulsions, oil-in-water emulsions, silicone-in-water emulsions, water-in-silicone emulsions, wax-in-water emulsions, water-in-oil-in-water triple emulsions, and the like, having the appearance of a cream, gel, or microemulsion. The emulsion may comprise an emulsifier, such as a nonionic, anionic or amphoteric surfactant.
In one embodiment, the oil phase of the emulsion has one or more organic compounds, including emollients; humectants (such as butylene glycol, propylene glycol, methyl glucitol-20, and glycerin); other water-dispersible or water-soluble components, including thickeners such as veegum or hydroxyalkyl cellulose; gelling agents, such as high MW polyacrylic acid, CARBOPOL 934; and mixtures thereof. The emulsion may have one or more emulsifiers capable of emulsifying the various components present in the composition.
Suitable compounds for the oil phase include, but are not limited to: a vegetable oil; esters such as octyl palmitate, isopropyl myristate and isopropyl palmitate; ethers, such as dioctyl ether; fatty alcohols such as cetyl alcohol, stearyl alcohol and phenylethyl alcohol; isoparaffins, such as isooctane, isododecane, and isohexadecane; silicone oils such as dimethylsiloxane, cyclic silicones, and polysiloxanes; hydrocarbon oils such as mineral oil, paraffin oil, isoeicosane and polyisobutylene; natural or synthetic waxes; and so on. Suitable hydrophobic hydrocarbon oils may be saturated or unsaturated, aliphatic in character and straight or branched chain or contain aliphatic or aromatic rings. The oleaginous phase may be composed of a single oil or a mixture of different oils.
Hydrogen oils include those hydrocarbon oils having from 6 to 20 carbon atoms, and in one embodiment, more than 10 to 16 carbonsAn atom. Representative hydrocarbons include decane, dodecane, tetradecane, tridecane and C8-20An isoparaffin. Paraffinic hydrocarbons are available from Exxon, Inc. (Exxon) under the ISOPARS trademark, and from Permethyl Corporation. In addition, C is also contemplated8-20Paraffinic hydrocarbons, such as C manufactured by Permethyl corporation under the trade name Permethyl 99A.TM12Isoparaffins (isododecane) are suitable. Commercially available C16Isoparaffins, such as isohexadecane (having the trade name Permethyl) are also suitable. In one embodiment, examples of volatile hydrocarbons include polydecanes such as isododecane and isodecane, including, for example, Permethyl-99A (Presperse Inc.) and C7-C8To C12-C15Isoparaffins such as Isopar series available from exxonmobil chemical company. A representative hydrocarbon solvent is isododecane.
The oil phase may include one or more waxes including, for example, rice bran wax, carnauba wax, ouricury wax, candelilla wax, montan wax, sugar cane wax, ozokerite wax, polyethylene wax, Fischer-Tropsch wax, beeswax, microcrystalline wax, silicone wax, fluorinated waxes, and any combination thereof.
Non-limiting emulsifiers include emulsifying waxes, emulsifying polyols, polyether polyols, polyethers, mono-or di-ester polyols, ethylene glycol monostearate, glycerol distearate, silicone containing emulsifiers, soy alcohol, fatty alcohols such as cetyl alcohol, acrylates, fatty acids such as stearic acid, fatty acid salts and mixtures thereof. In one embodiment, the emulsifier comprises soy sterol, cetyl alcohol, stearic acid, emulsifying wax, acrylates, silicone containing emulsifiers, and mixtures thereof. Other specific emulsifiers that may be used in the compositions of the present invention include, but are not limited to, one or more of the following: c10-30An alkyl acrylate crosspolymer; dimethicone PEG-7 isostearic acid, acrylamide copolymer; mineral oil; sorbitol esters; polyglyceryl-3-diisostearate; sorbitol monostearate, sorbitol tristearate, sorbitol sesquioleate, sorbitol monooleate; glycerides, e.g. glycerol monostearateFatty acid esters and glycerol monooleate; polyoxyethylene phenols such as polyoxyethylene octyl phenol and polyoxyethylene nonyl phenol; polyoxyethylene ethers such as polyoxyethylene cetyl ether and polyoxyethylene stearyl ether; polyoxyethylene glycol esters; polyoxyethylene sorbitol esters; dimethicone copolyol; polyglycerol esters such as polyglycerol-3-diisostearate; lauric acid glyceride; steareth-2, Steareth-10, and Steareth-20, to name a few. Additional emulsifiers are provided in INCI Ingredient Dictionary and Handbook (INCI Ingredient Dictionary and Handbook) 2006, 11 th edition, the disclosure of which is incorporated herein by reference.
These emulsifiers will generally be present in the composition in an amount of about 0.001% to about 10% by weight, specifically about 0.01% to about 5% by weight and more specifically in one embodiment about 0.1% to about 3% by weight.
The oil phase may comprise one or more volatile and/or non-volatile silicone oils. Volatile silicones include cyclic and linear volatile dimethylsiloxane silicones. In one embodiment, the volatile silicone may comprise a cyclomethicone comprising a tetramer (D)4) Pentamer (D)5And hexamers (D)6) Cyclomethicone or mixtures thereof. Volatile cyclomethicone-hexamethylcyclotrisiloxane, octamethyl-cyclotetrasiloxane and decamethyl-cyclopentasiloxane are mentioned in particular. Suitable dimethylsiloxanes are available from Dow Corning under the name Dow Corning 200Fluid and have viscosities ranging from 0.65 to 600,000 centistokes or higher. Exemplary non-polar volatile liquid silicone oils are disclosed in U.S. Pat. No. 4,781,917, which is incorporated herein by reference in its entirety. Additional Volatile Silicone materials are described in Todd et al, "Volatile Silicone fluids for Cosmetics" (Cosmetics and toiletries), 91: 27-32(1976), which is hereby incorporated by reference in its entirety. The viscosity of linear volatile silicones is typically less than about 5 centistokes at 25c, while the viscosity of cyclic silicones is less than about 10 centistokes at 25 c. Examples of volatile silicones of varying viscosity include Dow Corning 200,Dow Corning 244, Dow Corning 245, Dow Corning 344, and Dow Corning 345 (Dow Corning Corp.); SF-1204 and SF-1202 silicone fluids (general electric company silicone), GE 7207 and 7158 (general electric company); and SWS-03314(SWS Silicones Corp). Linear volatile silicones include low molecular weight polydimethylsiloxane compounds such as hexamethyldisiloxane, octamethyltrisiloxane, decamethyltetrasiloxane, and dodecamethylpentasiloxane, to name a few.
The non-volatile silicone oil will typically comprise a polyalkylsiloxane, a polyarylsiloxane, a polyalkylarylsiloxane, or mixtures thereof. In one embodiment, the polydimethylsiloxane is a non-volatile silicone oil. The viscosity of the non-volatile silicone oil is typically between about 10 and about 60,000 centistokes, in one embodiment between about 10 and about 10,000 centistokes, and in one embodiment still more between about 10 and about 500 centistokes at 25 ℃; and its boiling point is greater than 250 ℃ at ambient pressure. Non-limiting examples include dimethylpolysiloxane (dimethylsiloxane), phenyltrimethylsiloxane, and diphenyldimethylsiloxane. The volatile and nonvolatile silicone oils may be optionally substituted with various functional groups such as alkyl, aryl, amine, vinyl, hydroxyl, haloalkyl, alkylaryl, and acrylate groups, to name a few.
The water-in-silicone emulsion may be emulsified with a nonionic surfactant (emulsifier), such as a polydiorganosiloxane-polyoxyalkylene block copolymer, including those disclosed in U.S. Pat. No. 4,122,029, the disclosure of which is incorporated herein by reference. These emulsifiers typically comprise a polydiorganosiloxane backbone, typically a polydimethylsiloxane having side chains comprising- (EO) m-and/or- (PO) n-groups, wherein EO is ethyleneoxy and PO is 1, 2-propyleneoxy, the side chains typically being substituted with hydrogen or lower alkyl (e.g., C.sub.C.) groups1-6Usually C1-3) Capping or end-capping. Other suitable water-in-silicone emulsifiers are disclosed in U.S. Pat. No. 6,685,952, the disclosure of which is incorporated herein by reference. Commercially available water-in-silicone emulsifiers comprise: available from Dow Corning companyThose obtained by the names 3225C and 5225C FORMULATION AID; SILICONE SF-1528 available from general electric; ABIL EM 90 and EM 97 available from Goldschmidt chemical company (Hopewell, Va.); and the SILWET emulsifier series sold by the silicone section of Compton, Inc. (OSI Specialties).
Examples of water-in-silicone emulsifiers include, but are not limited to, dimethicone PEG 10/15 crosspolymer, dimethicone copolyol, cetyl dimethicone copolyol, PEG-15 lauryl dimethicone crosspolymer, lauryl methicone crosspolymer, cyclomethicone and dimethicone copolyol, dimethicone copolyol (and) octyl triglyceride/decyl triglyceride, polyglyceryl-4 isostearate (and) cetyl dimethicone copolyol (and) hexyl laurate, and dimethicone copolyol (and) cyclopentasiloxane. In one embodiment, examples of water-in-silicone emulsifiers include, but are not limited to, PEG/PPG-18/18 dimethicone (Dow Corning company tradename 5225C), PEG/PPG-19/19 dimethicone (Dow Corning company tradename BY25-337), cetyl PEG/PPG-10/1 dimethicone (Goldschmidt Chemical Corporation tradename Abil EM-90), PEG-12 dimethicone (General Electric company tradename SF 1288), lauryl PEG/PPG-18/18 methylsiloxane (Dow Corning company tradename 5200 FORMATION AID), PEG-12 dimethicone crosspolymer (Dow Corning company tradenames 9010 and 9011 silicone elastomer blends), PEG-10 dimethicone crosspolymer (Shin-Etsu Corporation tradename KSG-20), Dimethicone PEG-10/15 Cross-Linked Polymer (shinyle corporation under the trade name KSG-210) and Dimethicone PEG-7 isostearate.
Water-in-silicone emulsifiers will generally be present in the composition in an amount of from about 0.001% to about 10% by weight, specifically from about 0.01% to about 5% by weight and more specifically less than 1% by weight.
The aqueous phase of the emulsion may comprise one or more additional solvents, including lower alcohols, such as ethanol, isopropanol, and the like. The volatile solvent may also be a cosmetically acceptable ester such as butyl acetate or ethyl acetate; ketones such as acetone or ethyl methyl ketone; and so on.
The oil-containing phase will typically comprise from about 10% to about 99%, in one embodiment from about 20% to about 85%, and more in one embodiment from about 30% to about 70%, by weight of the total emulsion, and the aqueous phase will typically comprise from about 1% to about 90%, in one embodiment from about 5% to about 70%, and more in one embodiment from about 20% to about 60%, by weight of the total emulsion, based on the total weight of the emulsion. The aqueous phase will typically comprise from about 25% to about 100%, more typically from about 50% to about 95%, by weight of water.
The composition may comprise liposomes. Liposomes may include other additives or substances, and/or may be modified to more specifically reach or remain at a site after administration.
The composition may optionally include other cosmetic actives and excipients that will be apparent to those skilled in the art including, but not limited to, fillers, emulsifiers, antioxidants, surfactants, film formers, chelating agents, gelling agents, thickeners, emollients, humectants, moisturizers, vitamins, minerals, viscosity and/or rheology modifiers, sunscreen creams, keratins, depigmenting agents, retinol, hormonal compounds, alpha-hydroxy acids, alpha-keto acids, antimycotics, antifungals, antimicrobials, antivirals, analgesics, lipid compounds, antiallergics, H1 or H2 antihistamines, anti-inflammatory agents, anti-irritants, antineoplastic agents, immune system enhancers, immune system inhibitors, anti-glandular agents, anesthetics, antibacterial agents, insect repellents, skin cooling compounds, Skin protectants, skin permeation enhancers, exfoliants, lubricants, fragrances, colorants, depigmenting agents, hypopigmenting agents, preservatives (e.g., DMDM hydantoin/iodopropynyl butyl carbonate), stabilizers, pharmaceutical formulations, light stabilizers, neutralizing agents (e.g., triethanolamine), and mixtures thereof. In addition to the foregoing, the cosmetic compositions of the present invention may contain any other compound useful for treating skin conditions.
Examples of film formers include poly C10-30 alkyl acrylates and triethylpentanediol/adipic acid/glycerol crosspolymer.
In certain embodiments, the sunscreen composition may also include other cosmetic ingredients such as, but not limited to, humectants, emollients, moisturizers, anti-wrinkle ingredients, concealers, matte polishes, pigments, colorants, proteins, antioxidants, cosmetic powders, chelating agents, emulsifiers, Ultraviolet (UV) absorbers, oil absorbers, anti-foaming agents, detackifiers, thickeners, fragrances, preservatives, antimicrobials, fungistats, neutralizers, vitamins, plasticizers, cohesives, alkalizing and acidifying agents, fillers, solvents, and mixtures thereof. It will be appreciated by those skilled in the art that any other cosmetically acceptable ingredients may be used, i.e. those contained in the CFTA cosmetic ingredients dictionary, 3 rd edition.
The composition may contain additional ingredients such as alkalizing agents, emulsifiers, emollients, plasticizers, preservatives, humectants, moisturizers, solvents and tonicity agents or active ingredients suitable for providing anti-aging benefits. An example of a preferred additional ingredient comprises glycerol. Thickeners, such as gelling agents, may also be used. Examples include bentone, triglycerides, aluminum stearate, glycol esters of C18-C36, glyceryl tribehenate, glyceryl monostearate, alginate, carbomer, cellulose, gums, carrageenan, starch or silicates. Fillers may also optionally be added in amounts of about 1% to about 20%, preferably about 1% to about 10%. Examples of fillers include silica, PMMA, nylon, alumina, barium sulfate, or any other filler typically used in such compositions.
The composition may also contain at least one cosmetically active ingredient and/or at least one dermatologically active ingredient, i.e. an agent having a beneficial effect on the skin. The loading of such active ingredients can be achieved in any manner known to those skilled in the art. The composition may include other whitening or brightening agents that further include pigments or other light reflecting materials to hide the cause of or treat the discoloration.
In certain embodiments, the sunscreen composition is substantially stable to sunlight. In certain embodiments, the AUC in the post-illumination spectral absorption spectrum with the solar simulator is at least 80% of the AUC in the pre-illumination spectral absorption spectrum. The AUC in the spectral absorption spectrum after irradiation with the solar simulator is at least 90% of the AUC in the spectral absorption spectrum before irradiation. Solar stability can be measured by methods known to those skilled in the art.
In certain embodiments, the sunscreen composition is substantially waterproof. Water repellency can be measured by methods known to those skilled in the art. In certain embodiments, the composition is water resistant within 40 or 80 minutes, as encoded by the U.S. Food and Drug Administration in section 201.327(i) (7), volume 21 of Code of Federal Regulations (2019).
In certain embodiments, the sunscreen composition is phase stable. As used herein, "phase stability" means maintaining interfacial stability or suspension stability or both at each temperature of 4 ℃, 32-37 ℃, 40-45 ℃, 25 ℃ for at least 4 weeks. "interfacial stability" refers to the stability to coalescence and roughening of discontinuous phases in compositions having two or more phases. By "suspension stability" is meant stability to creaming and/or sedimentation of a discontinuous phase, e.g., solids suspended in a continuous phase.
In certain embodiments, the sunscreen composition maintains interfacial stability and suspension stability for at least 4 weeks at each of a temperature of 4 ℃, 32-37 ℃, 40-45 ℃, 25 ℃. To evaluate such stability conditions, the composition can be filled into an appropriately sized container, such as a clear 4 oz glass jar, in which the composition is fully visible.
The interfacial stability of sunscreen compositions can be visually assessed and considered unstable if at least two different immiscible phases of the composition are observed, as is well known in the art.
In certain embodiments, the sunscreen composition is not phase stable and, for example, is shaken prior to use.
As is also known in the art, the suspension stability of sunscreen compositions can be assessed visually or tactilely and considered unstable if a different separation or gradient of color, opacity, brittleness or other indicator of heterogeneity between different regions of the sample (i.e., top and bottom or other different regions) is observed. Alternatively, the suspension stability of the composition can be evaluated by, but is not limited to, Brookfield viscometry (Brookfield viscometry), and is considered unstable if there is a significant change (e.g., 5% or 10% or 20%) in the viscosity measurement between different regions (i.e., top and bottom or other different regions) in the sample. The brookfield viscosity can be measured with a brookfield laboratory viscometer from AMETEK (AMETEK inc., Middleboro, Mass.) using settings, spindles and speeds appropriate for the viscosity of the composition.
Overall bulk stability can also be assessed by other techniques known in the art, for example, by analyzing the chemical test for significant changes in chemical composition determined between different regions (i.e., top and bottom or other different regions) in a sample.
Sunscreen compositions may be applied by topical application to the skin. The method for applying may comprise spraying, painting, wiping or applying the composition directly onto the skin.
Sunscreen compositions can be prepared using mixing and blending methods well established in the sunscreen and cosmetic arts. In one embodiment, the composition is produced by: preparing an oil phase by mixing a UV absorbing compound with optional oil soluble or oil miscible ingredients; and preparing the aqueous phase by mixing water with the optional water-soluble or water-miscible ingredients. The oil phase and the aqueous phase may then be mixed in a manner sufficient to substantially uniformly disperse the oil phase in the aqueous phase such that the aqueous phase is continuous and the oil phase is not continuous.
The weight percentage of the aqueous phase included in the composition can range from about 30% to about 85%, such as from about 35% to about 75%, such as from about 40% to about 70%. The percentage of water in the aqueous phase by weight may be about 60% or more, such as about 70% or more, such as about 90% or more.
The composition may be combined with a "cosmetically acceptable topical carrier", i.e., a carrier which for topical use is capable of containing other ingredients dispersed or dissolved therein, and which has acceptable properties making it safe for topical use.
The cosmetically acceptable topical carrier may optionally include various additional oil-soluble materials and/or water-soluble materials conventionally used in compositions for skin at levels determined in the art. For example, surfactants, emulsifiers, beading or opacifying agents, thickeners, emollients, conditioning agents, humectants, chelating agents, exfoliants, preservatives, pH adjusters, and additives that enhance the appearance, feel, or fragrance of the composition, such as colorants, fragrances, tactile modifiers, and the like, may be included.
In certain embodiments, the composition comprises a pigment suitable for providing color or hiding power. The pigment may be one suitable in a color cosmetic product comprising a composition for application to hair, nails and/or skin, in particular the face. Color cosmetic compositions include, but are not limited to, foundations, concealers, foundations, blushes, mascaras, eye shadows, eyeliners, lipsticks, nail polishes, and color moisturizers. Pigments suitable for providing color or hiding power may be comprised of iron oxides including red and yellow iron oxides, titanium dioxide, super ocean colors, and chromium or chromium hydroxide colors, and mixtures thereof. The pigment may be a lake pigment precipitated onto an inert binder such as an insoluble salt, for example, organic dyes such as azo, indigo, triphenylmethane, anthraquinone and xanthine dyes designated as D & C and FD & C blue, brown, green, orange, red, yellow and the like. Examples of lake pigments include red #6, red #7, yellow #5, violet #2 and blue # 1. The pigment may be a coherent pigment. Examples of coherent pigments include those comprising: mica substrates, bismuth oxychloride substrates, and silica substrates, such as the mica/bismuth oxychloride/iron oxide pigments commercially available as CHROMALITE pigments (BASF), titanium dioxide and/or iron oxide coated on mica such as the commercially available FLAMENCO pigment (BASF), mica/titanium dioxide/iron oxide pigments comprising the commercially available KTZ pigments (Kobo products), CELLINI pearl pigments (BASF), and borosilicate-containing pigments such as REFLECKS pigments (BASF).
In one embodiment, the composition includes a humectant, such as a glycol, glycerin, or propylene glycol. The composition may include, for example, at least about 1.0 wt% humectant.
The composition may further comprise one or more other cosmetically acceptable active agents including, for example, anti-acne agents, oil control agents, antimicrobial agents, anti-fungal agents, anti-parasitic agents (including anti-monkey toxicants), external analgesics, antioxidants, moisturizers, nutrients, vitamins, energy boosters, antiperspirants, astringents, deodorants, tightening agents, anti-callousing agents and agents for skin conditioning, tanning agents, anti-wrinkle and anti-dark spots.
In certain embodiments, the composition is intended for use as a non-therapeutic treatment. In certain embodiments, the composition is an article intended to be rubbed, poured, sprayed or otherwise sprayed onto, introduced into, or otherwise applied to the human body for cleaning, beautifying, enhancing appeal, or altering appearance, in accordance with the american FD & C Act 201.
Amounts of other cosmetically active agents may range from about 0.001% to about 20% by weight of the composition, for example from about 0.005% to about 10% by weight of the composition, such as from about 0.01% to about 5% by weight of the composition.
According to some aspects, the sunscreen formulations described herein are ecologically comparable compositions. For example, sunscreen formulations are compatible with biological life and are not harmful to marine ecosystems (particularly for tropical environments with coral reefs). Specifically, the sunscreen formulation is free of components that inhibit cell growth or cell replication in a marine environment. In some examples, this may be achieved by the following sunscreen formulation: bis-ethylhexyl-free methoxyphenyltriazine (BEMT), cinnamate, benzophenone, a derivative of camphor, titanium oxide, tea tree essential oil, Eisenia champ extract, Acanthopanax trifoliatus bamboo culm extract (Bambousa Arundinacea extract), shea butter (Karit), animal derived fat, Arleia oil, tocopherol acetate, tocopherol, retinol, polyphenolic compounds extracted from green tea, or a mixture thereof. In some aspects, the sunscreen formulation may comprise diisopropyl sebacate, dimethylmethoxychromanol, gluconolactone, potassium sorbate, dimethylmethoxychromanol, decyl cocoate, pentanediol, dimethicone, hydrolyzed citrus immature fruit extract.
Exemplary aspects are described.
The following exemplary embodiments are provided, the numbering of which should not be construed as specifying the level of importance:
aspect 1 provides a UV filter composition comprising:
three UV-B filters;
a UV-A filter; and
UV-A + UV-B broadband filters.
Aspect 2 provides a sunscreen composition comprising the UV filter composition of aspect 1.
Aspect 3 provides a sunscreen composition according to aspect 2, comprising one or more solubilizers.
Aspect 4 provides the sunscreen composition of aspect 3, wherein the one or more solubilizing agents are selected from the group consisting of: diisopropyl sebacate, dioctyl carbonate, decyl cocoate, diisopropyl adipate, isopropyl lauroyl sarcosinate, dibutyl adipate, butyl octyl salicylate, C12-15 alkyl benzoate, and diethyl hexyl succinate.
Aspect 5 provides the sunscreen composition of any one of aspects 2 to 4, wherein:
the UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter agent is ethylhexyl triazone;
the second UV-B light filter is octyl salicylate;
the third UV-B light filter is isoamyl p-methoxycinnamate; and is
The broadband UV-A and UV-B light filter is bis-ethylhexyl oxyphenol methoxyphenyl triazine.
Aspect 6 provides the sunscreen composition of aspect 5, wherein
The UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter is ethylhexyl triazone;
the second UV-B light filter is octyl salicylate;
the third UV-B filter agent is isoamyl p-methoxycinnamate; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of the UV-A filter to the UV-B filter to the broadband filter is about 2: 7: 1.
Aspect 7 provides the sunscreen composition of aspect 5, wherein
The UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter is ethylhexyl triazone;
the second UV-B light filter is octyl salicylate;
the third UV-B filter agent is isoamyl p-methoxycinnamate; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of the UV-A filter to the UV-B filter to the broadband filter is about 4: 11: 2.
Aspect 8 provides the sunscreen composition of aspect 5, wherein
The UV-A light filtering agent is butyl methoxy dibenzoyl methane;
the first UV-B filter is ethylhexyl triazone;
the second UV-B light filter is octyl salicylate;
the third UV-B light filter is isoamyl p-methoxycinnamate; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of the UV-A filter to the UV-B filter to the broadband filter is about 4: 13: 2.
Aspect 9 provides the sunscreen composition of any of aspects 2-4, wherein:
the UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter is ethylhexyl triazone;
the second UV-B light filter is octyl salicylate;
the third UV-B filter agent is diethyl hexyl butamido triazone; and is
The broadband UV-A and UV-B light filter is bis-ethylhexyl oxyphenol methoxyphenyl triazine.
Aspect 10 provides the sunscreen composition of aspect 9, wherein
The UV-A light filtering agent is butyl methoxy dibenzoyl methane;
the first UV-B filter is ethylhexyl triazone;
the second UV-B filter agent is octyl salicylate;
the third UV-B filter agent is diethyl hexyl butamido triazone; and is provided with
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of the UV-A filter to the UV-B filter to the broadband filter is about 2: 5.5: 1.
Aspect 11 provides the sunscreen composition of aspect 9, wherein
The UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter is ethylhexyl triazone;
the second UV-B light filter is octyl salicylate;
the third UV-B filter agent is diethyl hexyl butamido triazone; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of the UV-A filter to the UV-B filter to the broadband filter is about 4: 11: 2.
Aspect 12 provides the sunscreen composition of aspect 9, wherein
The UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter agent is ethylhexyl triazone;
the second UV-B light filter is octyl salicylate;
the third UV-B filter agent is diethyl hexyl butamido triazone; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of the UV-A filter to the UV-B filter to the broadband filter is about 4: 13: 2.
Aspect 13 provides the sunscreen composition of any one of aspects 2-4, wherein:
the UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter agent is isoamyl p-methoxycinnamate;
the second UV-B light filter is octyl salicylate;
the third UV-B filter agent is diethyl hexyl butamido triazone; and is
The broadband UV-A and UV-B filter agents are bis-ethylhexyl oxyphenol methoxyphenyl triazine.
Aspect 14 provides the sunscreen composition of aspect 13, wherein
The UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter agent is isoamyl p-methoxycinnamate;
the second UV-B light filter is octyl salicylate;
the third UV-B filter agent is diethyl hexyl butamido triazone; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of the UV-A filter to the UV-B filter to the broadband filter is about 2: 7: 1.
Aspect 15 provides the sunscreen composition of aspect 13, wherein
The UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter agent is isoamyl p-methoxycinnamate;
the second UV-B light filter is octyl salicylate;
the third UV-B filter agent is diethyl hexyl butamido triazone; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of the UV-A filter to the UV-B filter to the broadband filter is about 1: 3: 1.
Aspect 16 provides the sunscreen composition of aspect 13, wherein
The UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter agent is isoamyl p-methoxycinnamate;
the second UV-B filter agent is octyl salicylate;
the third UV-B filter agent is diethyl hexyl butamido triazone; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of the UV-A filter to the UV-B filter to the broadband filter is about 4: 13: 2.
Aspect 17 provides the sunscreen composition of any of aspects 2-16, wherein the one or more solubilizing agents is diisopropyl sebacate.
Aspect 18 provides the sunscreen composition of aspect 17, wherein the composition comprises from about 8% to about 10% diisopropyl sebacate.
Aspect 19 provides the sunscreen composition of aspect 18, wherein the composition comprises from about 6% to about 8% diisopropyl sebacate.
Aspect 20 provides the sunscreen composition of aspect 5, wherein
The UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter is ethylhexyl triazone;
the second UV-B light filter is octyl salicylate;
the third UV-B light filter is isoamyl p-methoxycinnamate; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of the UV-A filter to the UV-B filter to the broadband filter is about 6: 17: 4.
Aspect 21 provides the sunscreen composition of aspect 9, wherein
The UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter is ethylhexyl triazone;
the second UV-B light filter is octyl salicylate;
the third UV-B filter agent is diethyl hexyl butamido triazone; and is provided with
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of the UV-A filter to the UV-B filter to the broadband filter is about 6: 17: 4.
Aspect 22 provides the sunscreen composition of aspect 13, wherein
The UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter agent is isoamyl p-methoxycinnamate;
the second UV-B light filter is octyl salicylate;
the third UV-B filter agent is diethyl hexyl butamido triazone; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of the UV-A filter to the UV-B filter to the broadband filter is about 6: 17: 4.
Aspect 23 provides the sunscreen composition of any of aspects 22-24, wherein the one or more solubilizing agents is diisopropyl sebacate and dioctyl carbonate.
Aspect 24 provides the sunscreen composition of aspect 25, wherein the composition comprises from about 13% to about 15.5% of a mixture of diisopropyl sebacate and dioctyl carbonate.
Aspect 25 provides the sunscreen composition of aspect 26, wherein the composition comprises from about 13.5% to about 15% of the mixture of diisopropyl sebacate and dioctyl carbonate.
Aspect 26 provides the sunscreen composition of aspect 5, wherein
The UV-A light filtering agent is butyl methoxy dibenzoyl methane;
the first UV-B filter is ethylhexyl triazone;
the second UV-B filter agent is octyl salicylate;
the third UV-B light filter is isoamyl p-methoxycinnamate; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 7: 13: 6.
Aspect 27 provides the sunscreen composition of aspect 9, wherein
The UV-A light filtering agent is butyl methoxy dibenzoyl methane;
the first UV-B filter agent is ethylhexyl triazone;
the second UV-B filter agent is octyl salicylate;
the third UV-B filter agent is diethyl hexyl butamido triazone; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of the UV-A filter to the UV-B filter to the broadband filter is about 7: 17: 6.
Aspect 28 provides the sunscreen composition of aspect 13, wherein
The UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter agent is isoamyl p-methoxycinnamate;
the second UV-B light filter is octyl salicylate;
the third UV-B filter agent is diethyl hexyl butamido triazone; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of the UV-A filter to the UV-B filter to the broadband filter is about 7: 13: 6.
Aspect 29 provides a sunscreen cream composition according to any one of aspects 26-28, wherein the one or more solubilizers are decyl cocoate, isopropyl lauroyl sarcosinate, and dibutyl adipate.
Aspect 30 provides the sunscreen composition of aspect 29, wherein the composition comprises from about 16% to about 18% of a mixture of decyl cocoate, isopropyl lauroyl sarcosinate, and dibutyl adipate.
Aspect 31 provides the sunscreen cream composition of aspect 30, wherein the composition comprises from about 16.5% to about 17.5% of a mixture of decyl cocoate, isopropyl lauroyl sarcosinate, and dibutyl adipate.
Aspect 32 provides the sunscreen composition of aspect 5, wherein
The UV-A light filtering agent is butyl methoxy dibenzoyl methane;
the first UV-B filter is ethylhexyl triazone;
the second UV-B light filter is octyl salicylate;
the third UV-B light filter is isoamyl p-methoxycinnamate; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of the UV-A filter to the UV-B filter to the broadband filter is about 1: 2: 1.
Aspect 33 provides the sunscreen composition of aspect 9, wherein
The UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter is ethylhexyl triazone;
the second UV-B light filter is octyl salicylate;
the third UV-B filter agent is diethyl hexyl butamido triazone; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of the UV-A filter to the UV-B filter to the broadband filter is about 3: 8.5: 2.
Aspect 34 provides the sunscreen composition of aspect 13, wherein
The UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter agent is isoamyl p-methoxycinnamate;
the second UV-B filter agent is octyl salicylate;
the third UV-B filter agent is diethyl hexyl butamido triazone; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of the UV-A filter to the UV-B filter to the broadband filter is about 1: 2: 1.
Aspect 35 provides the sunscreen cream composition of any of aspects 32-34, wherein the one or more solubilizers are decyl cocoate and diisopropyl sebacate.
Aspect 36 provides the sunscreen cream composition of aspect 35, wherein the composition comprises from about 19% to about 21% of a mixture of decyl cocoate and diisopropyl sebacate.
Aspect 37 provides the sunscreen composition of aspect 36, wherein the composition comprises from about 19.5% to about 20.5% of a mixture of decyl cocoate and diisopropyl sebacate.
Aspect 38 provides the sunscreen composition of aspect 5, wherein
The UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter is ethylhexyl triazone;
the second UV-B light filter is octyl salicylate;
the third UV-B light filter is isoamyl p-methoxycinnamate; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of the UV-A filter to the UV-B filter to the broadband filter is about 7: 13: 6.
Aspect 39 provides the sunscreen composition of aspect 9, wherein
The UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter is ethylhexyl triazone;
the second UV-B light filter is octyl salicylate;
the third UV-B filter agent is diethyl hexyl butamido triazone; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of the UV-A filter to the UV-B filter to the broadband filter is about 7: 11: 6.
Aspect 40 provides the sunscreen composition of aspect 13, wherein
The UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter agent is isoamyl p-methoxycinnamate;
the second UV-B filter agent is octyl salicylate;
the third UV-B filter agent is diethyl hexyl butamido triazone; and is provided with
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of the UV-A filter to the UV-B filter to the broadband filter is about 7: 11: 6.
Aspect 41 provides a sunscreen cream composition according to any of aspects 38-40, wherein the one or more solubilizers are diisopropyl sebacate, dioctyl carbonate, and decyl cocoate.
Aspect 42 provides the sunscreen cream composition of aspect 41, wherein the composition includes from about 19.5% to about 21.5% of a mixture of diisopropyl sebacate, dioctyl carbonate, and decyl cocoate.
Aspect 43 provides the sunscreen cream composition of aspect 42, wherein the composition comprises from about 20% to about 21% of a mixture of diisopropyl sebacate, dioctyl carbonate, and decyl cocoate.
Aspect 44 provides the sunscreen composition of any of aspects 38-40, wherein the one or more solubilizing agents is diisopropyl sebacate, decyl cocoate, and isopropyl lauroyl sarcosinate.
Aspect 45 provides the sunscreen composition of aspect 44, wherein the composition includes from about 16% to about 18% of a mixture of diisopropyl sebacate, decyl cocoate, and isopropyl lauroyl sarcosinate.
Aspect 46 provides the sunscreen composition of aspect 45, wherein the composition comprises from about 16.5% to about 17.5% of a mixture of diisopropyl sebacate, decyl cocoate, and isopropyl lauroyl sarcosinate.
Aspect 47 provides the sunscreen composition of aspect 5, wherein
The UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter is ethylhexyl triazone;
the second UV-B light filter is octyl salicylate;
the third UV-B light filter is isoamyl p-methoxycinnamate; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of the UV-A filter to the UV-B filter to the broadband filter is about 9: 24: 8.
Aspect 48 provides the sunscreen composition of aspect 9, wherein
The UV-A light filtering agent is butyl methoxy dibenzoyl methane;
the first UV-B filter is ethylhexyl triazone;
the second UV-B light filter is octyl salicylate;
the third UV-B filter agent is diethyl hexyl butamido triazone; and is provided with
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of the UV-A filter to the UV-B filter to the broadband filter is about 9: 4: 8.
Aspect 49 provides the sunscreen composition of aspect 13, wherein
The UV-A light filtering agent is butyl methoxy dibenzoyl methane;
the first UV-B filter agent is isoamyl p-methoxycinnamate;
the second UV-B light filter is octyl salicylate;
the third UV-B filter agent is diethyl hexyl butamido triazone; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of the UV-A filter to the UV-B filter to the broadband filter is about 9: 24: 8.
Aspect 50 provides the sunscreen cream composition of any of aspects 47-49, wherein the one or more solubilizers are diisopropyl sebacate, dioctyl carbonate, and decyl cocoate.
Aspect 51 provides the sunscreen composition of aspect 5, wherein the composition comprises from about 25% to about 29% of a mixture of diisopropyl sebacate, dioctyl carbonate, and decyl cocoate.
Aspect 52 provides the sunscreen cream composition of aspect 51, wherein the composition comprises from about 26% to about 28% of a mixture of diisopropyl sebacate, dioctyl carbonate, and decyl cocoate.
Aspect 53 provides the sunscreen composition of any of aspects 47-51, wherein the one or more solubilizing agents is diisopropyl sebacate and diisopropyl adipate.
Aspect 54 provides the sunscreen composition of aspect 53, wherein the composition comprises from about 32.5% to about 35/5% of the mixture of diisopropyl sebacate and diisopropyl adipate.
Aspect 55 provides the sunscreen composition of aspect 54, wherein the composition comprises from about 33% to about 35% of the mixture of diisopropyl sebacate and diisopropyl adipate.
Aspect 56 provides the sunscreen composition of any of aspects 47-49, wherein the one or more solubilizing agents is diisopropyl sebacate, decyl cocoate, and isopropyl lauroyl sarcosinate.
Aspect 57 provides the sunscreen cream composition of aspect 56, wherein the composition comprises from about 22.5% to about 25.5% of a mixture of diisopropyl sebacate, decyl cocoate, and isopropyl lauroyl sarcosinate.
Aspect 58 provides the sunscreen composition of aspect 57, wherein the composition comprises from about 23% to about 25% of a mixture of diisopropyl sebacate, decyl cocoate, and isopropyl lauroyl sarcosinate.
Aspect 59 provides the sunscreen composition of any of aspects 47-49, wherein the one or more solubilizers are decyl cocoate, isopropyl lauroyl sarcosinate, and dibutyl adipate.
Aspect 60 provides the sunscreen composition of aspect 59, wherein the composition comprises from about 28% to about 31% of a mixture of decyl cocoate, isopropyl lauroyl sarcosinate, and dibutyl adipate.
Aspect 61 provides the sunscreen composition of aspect 60, wherein the composition comprises from about 29% to about 3% of a mixture of decyl cocoate, isopropyl lauroyl sarcosinate, and dibutyl adipate.
Aspect 62 provides the sunscreen composition of aspect 5, wherein
The UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter is ethylhexyl triazone;
the second UV-B filter agent is octyl salicylate;
the third UV-B light filter is isoamyl p-methoxycinnamate; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of the UV-A filter to the UV-B filter to the broadband filter is about 9: 19: 8.
Aspect 63 provides the sunscreen composition of aspect 9, wherein
The UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter is ethylhexyl triazone;
the second UV-B light filter is octyl salicylate;
the third UV-B filter agent is diethyl hexyl butamido triazone; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of the UV-A filter to the UV-B filter to the broadband filter is about 9: 19: 8.
Aspect 64 provides the sunscreen composition of aspect 13, wherein
The UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter agent is isoamyl p-methoxycinnamate;
the second UV-B light filter is octyl salicylate;
the third UV-B filter agent is diethyl hexyl butamido triazone; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of the UV-A filter to the UV-B filter to the broadband filter is about 9: 19: 8.
Aspect 65 provides the sunscreen cream composition of any of aspects 62-64, wherein the one or more solubilizers are diisopropyl sebacate, decyl cocoate, and isopropyl lauroyl sarcosinate.
Aspect 66 provides the sunscreen cream composition of aspect 65, wherein the composition includes from about 18% to about 22% of a mixture of diisopropyl sebacate, decyl cocoate, and isopropyl lauroyl sarcosinate.
Aspect 67 provides the sunscreen cream composition of aspect 66, wherein the composition includes from about 20% to about 21% of a mixture of diisopropyl sebacate, decyl cocoate, and isopropyl lauroyl sarcosinate.
Aspect 68 provides the sunscreen cream composition according to any of aspects 62-64, wherein the one or more solubilizers are diisopropyl sebacate, diisopropyl adipate, and decyl cocoate.
Aspect 69 provides the sunscreen composition of aspect 68, wherein the composition comprises from about 29% to about 33% diisopropyl sebacate, a mixture of diisopropyl adipate and decyl cocoate.
Aspect 70 provides the sunscreen cream composition of aspect 69, wherein the composition comprises from about 30% to about 32% diisopropyl sebacate, a mixture of diisopropyl adipate and decyl cocoate.
Aspect 71 provides the sunscreen composition of aspect 5, wherein
The UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter is ethylhexyl triazone;
the second UV-B light filter is octyl salicylate;
the third UV-B light filter is isoamyl p-methoxycinnamate; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of the UV-A filter to the UV-B filter to the broadband filter is about 9: 17: 8.
Aspect 72 provides the sunscreen composition of aspect 9, wherein
The UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter is ethylhexyl triazone;
the second UV-B light filter is octyl salicylate;
the third UV-B filter agent is diethyl hexyl butamido triazone; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 9: 20: 7.
Aspect 73 provides the sunscreen composition of aspect 13, wherein
The UV-A light filtering agent is butyl methoxy dibenzoyl methane;
the first UV-B filter agent is isoamyl p-methoxycinnamate;
the second UV-B light filter is octyl salicylate;
the third UV-B filter agent is diethyl hexyl butamido triazone; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of the UV-A filter to the UV-B filter to the broadband filter is about 9: 17: 8.
Aspect 74 provides the sunscreen cream composition of any of aspects 71-73, wherein the one or more solubilizers are diisopropyl sebacate, diisopropyl adipate, and decyl cocoate.
Aspect 75 provides the sunscreen cream composition of aspect 74, wherein the composition comprises from about 25% to about 2827% of a mixture of diisopropyl sebacate, diisopropyl adipate, and decyl cocoate.
Aspect 76 provides the sunscreen composition of aspect 75, wherein the composition comprises from about 26% to about 27% diisopropyl sebacate, a mixture of diisopropyl adipate and decyl cocoate.
Aspect 77 provides the sunscreen composition of aspect 5, wherein
The UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter is ethylhexyl triazone;
the second UV-B light filter is octyl salicylate;
the third UV-B filter agent is isoamyl p-methoxycinnamate; and is provided with
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of the UV-A filter to the UV-B filter to the broadband filter is about 9: 25: 7.
Aspect 78 provides the sunscreen composition of aspect 9, wherein
The UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter agent is ethylhexyl triazone;
the second UV-B light filter is octyl salicylate;
the third UV-B filter agent is diethyl hexyl butamido triazone; and is provided with
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of the UV-A filter to the UV-B filter to the broadband filter is about 9: 25: 7.
Aspect 79 provides a sunscreen composition according to aspect 13, wherein
The UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter agent is isoamyl p-methoxycinnamate;
the second UV-B light filter is octyl salicylate;
the third UV-B filter agent is diethyl hexyl butamido triazone; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of the UV-A filter to the UV-B filter to the broadband filter is about 9: 25: 7.
Aspect 80 provides the sunscreen composition of any of aspects 77-79, wherein the one or more solubilizers are diisopropyl sebacate and dioctyl carbonate.
Aspect 81 provides the sunscreen composition of aspect 80, wherein the composition comprises from about 17% to about 20% of a mixture of diisopropyl sebacate and dioctyl carbonate.
Aspect 82 provides the sunscreen composition of aspect 81, wherein the composition comprises from about 18% to about 19% of a mixture of diisopropyl sebacate and dioctyl carbonate.
Aspect 83 provides the sunscreen composition of aspect 5, wherein
The UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter agent is ethylhexyl triazone;
the second UV-B light filter is octyl salicylate;
the third UV-B light filter is isoamyl p-methoxycinnamate; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of the UV-A filter to the UV-B filter to the broadband filter is about 9: 23: 8.
Aspect 84 provides the sunscreen composition of aspect 9, wherein
The UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter agent is ethylhexyl triazone;
the second UV-B filter agent is octyl salicylate;
the third UV-B filter agent is diethyl hexyl butamido triazone; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of the UV-A filter to the UV-B filter to the broadband filter is about 9: 23: 8.
Aspect 85 provides the sunscreen composition of aspect 13, wherein
The UV-A light filtering agent is butyl methoxy dibenzoyl methane;
the first UV-B filter agent is isoamyl p-methoxycinnamate;
the second UV-B light filter is octyl salicylate;
the third UV-B filter agent is diethyl hexyl butamido triazone; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of the UV-A filter to the UV-B filter to the broadband filter is about 9: 23: 8.
Aspect 86 provides the sunscreen cream composition of any of aspects 83-85, wherein the one or more solubilizers are diisopropyl sebacate, dioctyl carbonate, and decyl cocoate.
Aspect 87 provides the sunscreen composition of aspect 86, wherein the composition comprises from about 20% to about 23% of a mixture of diisopropyl sebacate, dioctyl carbonate, and decyl cocoate.
Aspect 88 provides the sunscreen cream composition of aspect 87, wherein the composition comprises from about 21% to about 22% of a mixture of diisopropyl sebacate, dioctyl carbonate, and decyl cocoate.
Aspect 89 provides the sunscreen composition of aspect 5, wherein
The UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter agent is ethylhexyl triazone;
the second UV-B light filter is octyl salicylate;
the third UV-B light filter is isoamyl p-methoxycinnamate; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 9: 18: 8.
Aspect 90 provides the sunscreen composition of aspect 9, wherein
The UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter is ethylhexyl triazone;
the second UV-B light filter is octyl salicylate;
the third UV-B filter agent is diethyl hexyl butamido triazone; and is provided with
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of the UV-A filter to the UV-B filter to the broadband filter is about 9: 20: 7.
Aspect 91 provides the sunscreen composition of aspect 13, wherein
The UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter agent is isoamyl p-methoxycinnamate;
the second UV-B light filter is octyl salicylate;
the third UV-B filter agent is diethyl hexyl butamido triazone; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 9: 18: 8.
Aspect 92 provides the sunscreen composition of any of aspects 89-91, wherein the one or more solubilizing agents is dibutyl adipate.
Aspect 93 provides the sunscreen composition of aspect 92, wherein the composition comprises about 36% to about 39% dibutyl adipate.
Aspect 94 provides the sunscreen composition of aspect 93, wherein the composition comprises from about 37% to about 38% dibutyl adipate.
Aspect 95 provides the sunscreen composition of aspect 5, wherein
The UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter is ethylhexyl triazone;
the second UV-B light filter is octyl salicylate;
the third UV-B light filter is isoamyl p-methoxycinnamate; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 9: 18: 8.
Aspect 96 provides the sunscreen composition of aspect 9, wherein
The UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter is ethylhexyl triazone;
the second UV-B light filter is octyl salicylate;
the third UV-B filter agent is diethyl hexyl butamido triazone; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of the UV-A filter to the UV-B filter to the broadband filter is about 9: 20: 7.
Aspect 97 provides the sunscreen composition of aspect 13, wherein
The UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter agent is isoamyl p-methoxycinnamate;
the second UV-B light filter is octyl salicylate;
the third UV-B filter agent is diethyl hexyl butamido triazone; and is provided with
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of UV-A filter to UV-B filter to broadband filter is about 9: 18: 8.
Aspect 98 provides the sunscreen cream composition of any of aspects 94-97, wherein the one or more solubilizers are diisopropyl sebacate, dioctyl carbonate, and decyl cocoate.
Aspect 99 provides the sunscreen composition of aspect 98, wherein the composition includes from about 23% to about 26% of a mixture of diisopropyl sebacate, dioctyl carbonate, and decyl cocoate.
Aspect 100 provides the sunscreen composition of aspect 99, wherein the composition comprises from about 24% to about 25% of a mixture of diisopropyl sebacate, dioctyl carbonate, and decyl cocoate.
Aspect 101 provides the sunscreen cream composition of any of aspects 95-97, wherein the one or more solubilizers are diisopropyl sebacate, decyl cocoate, and diisopropyl adipate.
Aspect 102 provides the sunscreen composition of aspect 101, wherein the composition comprises from about 25% to about 28% of a mixture of diisopropyl sebacate, decyl cocoate, and diisopropyl adipate.
Aspect 103 provides the sunscreen cream composition of aspect 102, wherein the composition comprises from about 26% to about 27% of a mixture of diisopropyl sebacate, decyl cocoate, and diisopropyl adipate.
Aspect 104 provides the sunscreen composition of aspect 5, wherein
The UV-A light filtering agent is butyl methoxy dibenzoyl methane;
the first UV-B filter agent is ethylhexyl triazone;
the second UV-B filter agent is octyl salicylate;
the third UV-B light filter is isoamyl p-methoxycinnamate; and is provided with
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of the UV-A filter to the UV-B filter to the broadband filter is about 9: 155: 8.
Aspect 105 provides the sunscreen composition of aspect 9, wherein
The UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter is ethylhexyl triazone;
the second UV-B light filter is octyl salicylate;
the third UV-B filter agent is diethyl hexyl butamido triazone; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of the UV-A filter to the UV-B filter to the broadband filter is about 9: 14: 8.
Aspect 106 provides the sunscreen composition of aspect 13, wherein
The UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter agent is isoamyl p-methoxycinnamate;
the second UV-B light filter is octyl salicylate;
the third UV-B filter agent is diethyl hexyl butamido triazone; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of the UV-A filter to the UV-B filter to the broadband filter is about 9: 15: 8.
Aspect 107 provides the sunscreen composition of any of aspects 104-106, wherein the one or more solubilizing agents is dioctyl carbonate.
Aspect 108 provides the sunscreen composition of aspect 107, wherein the composition includes from about 26% to about 27% dioctyl carbonate.
Aspect 109 provides the sunscreen composition of aspect 108, wherein the composition comprises from about 24% to about 26% dioctyl carbonate.
Aspect 110 provides the sunscreen composition of aspect 5, wherein
The UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter is ethylhexyl triazone;
the second UV-B light filter is octyl salicylate;
the third UV-B light filter is isoamyl p-methoxycinnamate; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of the UV-A filter to the UV-B filter to the broadband filter is about 9: 16: 8.
Aspect 111 provides the sunscreen composition of aspect 9, wherein
The UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter is ethylhexyl triazone;
the second UV-B light filter is octyl salicylate;
the third UV-B filter agent is diethyl hexyl butamido triazone; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of the UV-A filter to the UV-B filter to the broadband filter is about 9: 14: 8.
Aspect 112 provides the sunscreen composition of aspect 13, wherein
The UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter agent is isoamyl p-methoxycinnamate;
the second UV-B light filter is octyl salicylate;
the third UV-B filter agent is diethyl hexyl butamido triazone; and is provided with
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of the UV-A filter to the UV-B filter to the broadband filter is about 9: 16: 8.
Aspect 113 provides the sunscreen cream composition of any of aspects 110-112, wherein the one or more solubilizers are diisopropyl sebacate, dioctyl carbonate, and decyl cocoate.
Aspect 114 provides the sunscreen cream composition of aspect 113, wherein the composition comprises from about 24% to about 27% of a mixture of diisopropyl sebacate, dioctyl carbonate, and decyl cocoate.
Aspect 115 provides the sunscreen cream composition of aspect 114, wherein the composition comprises from about 25% to about 26% of a mixture of diisopropyl sebacate, dioctyl carbonate, and decyl cocoate.
Aspect 116 provides the sunscreen composition of aspect 5, wherein
The UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter is ethylhexyl triazone;
the second UV-B light filter is octyl salicylate;
the third UV-B light filter is isoamyl p-methoxycinnamate; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of the UV-A filter to the UV-B filter to the broadband filter is about 9: 15: 8.
Aspect 117 provides the sunscreen composition of aspect 9, wherein
The UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter is ethylhexyl triazone;
the second UV-B filter agent is octyl salicylate;
the third UV-B filter agent is diethyl hexyl butamido triazone; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of the UV-A filter to the UV-B filter to the broadband filter is about 9: 14: 8.
Aspect 118 provides the sunscreen composition of aspect 13, wherein
The UV-A light filter is butyl methoxydibenzoylmethane;
the first UV-B filter agent is isoamyl p-methoxycinnamate;
the second UV-B light filter is octyl salicylate;
the third UV-B filter agent is diethyl hexyl butamido triazone; and is
The broadband UV-A and UV-B light filtering agent is bis-ethylhexyl oxyphenol methoxyphenyl triazine,
wherein the mass ratio of the UV-A filter to the UV-B filter to the broadband filter is about 9: 15: 8.
Aspect 119 provides the sunscreen composition of any of aspects 116-118, wherein the one or more solubilizing agents is dibutyl adipate and decyl cocoate.
Aspect 120 provides the sunscreen composition of aspect 119, wherein the composition comprises from about 31% to about 34% of a mixture of diisopropyl sebacate, dioctyl carbonate, and decyl cocoate.
Aspect 121 provides the sunscreen composition of aspect 120, wherein the composition comprises from about 32% to about 33% of a mixture of diisopropyl sebacate, dioctyl carbonate, and decyl cocoate.
Aspect 122 provides a method for protecting skin from the sun, the method comprising applying to the skin a sunscreen composition according to any one of aspects 2 to 121.
Example 1
The following formulations can be prepared using methods known in the art.
Table 1: sunscreen formulations.
Figure BDA0003654442640000691
Example 2
The following formulations can be prepared using methods known in the art.
Table 2: sunscreen formulations.
Figure BDA0003654442640000692
Figure BDA0003654442640000701
Example 3
The following formulations can be prepared using methods known in the art.
Table 3: sunscreen formulations.
Figure BDA0003654442640000702
Example 4
The following formulations can be prepared using methods known in the art.
Table 4: sunscreen formulations.
Figure BDA0003654442640000703
Figure BDA0003654442640000711
Example 5
A facial cream with an SPF of at least 50 is prepared in emulsion form. An oil phase is prepared comprising the UV filter composition as described herein, one or more solubilizers as described herein, a thickener, an emulsifier, and a wax. The oil phase was added to the aqueous phase comprising water and glycerol with mixing. Rheology modifiers, pigments, preservatives, fragrances and active ingredients may be added.
Example 6
And (3) preparing various sunscreen creams by using UV filters with different concentrations. Specifically, three sunscreen creams each comprising a total of five UV filters were developed and compared with sunscreen cream formulations comprising nine UV filters. The formulations are presented below and the types and concentrations of UV filters are listed.
Table 5: comparison type
Figure BDA0003654442640000712
Table 6: formula 1
Figure BDA0003654442640000721
Table 7: formula 2
Figure BDA0003654442640000722
Table 8: formula 3
Figure BDA0003654442640000723
The quotient of Sun Protection Factor (SPF), Persistent Pigment Darkening (PPD) and SPF/PPD was compared between comparative formula, formula 1, formula 2 and formula 3. The results show that formula 1, formula 2, and formula 3 give equal or better performance than the comparative formula. It is noteworthy that equivalent or better performance is achieved by formulas 1, 2, and 3 with less total filter and lower total concentration of filter in wt%. The results are shown in FIGS. 1-6.
Figure 1 shows that the in vivo SPF of formulas 1 and 2 is substantially the same as the comparative SPF. Fig. 2 shows that the PPD of formula 1 is substantially the same as the comparative formula. Figure 3 shows that the SPF/PPD quotient of formula 1 is substantially the same as the comparative formula. Figure 4 shows the SPF of equation 3 is improved over the comparative equation. Fig. 5 shows that the PPD of formula 3 is substantially the same as the comparative formula. Figure 6 shows that the SPF/PPD quotient of equation 3 is substantially the same as the comparative equation.
All references, patents, or applications cited in this application, whether in the united states or in foreign countries, are hereby incorporated by reference as if written herein in their entirety. In creating any inconsistencies, the material actually disclosed herein will prevail.
From the foregoing description, one skilled in the art can easily ascertain the essential characteristics of the present invention, and without departing from the spirit and scope thereof, can make various changes and modifications of the invention to adapt it to various usages and conditions.

Claims (16)

1. A UV filter composition comprising:
three UV-B filters;
a UV-A filter; and
UV-A + UV-B broadband filters.
2. A sunscreen composition comprising the UV filter composition of claim 1.
3. The sunscreen composition of claim 2, further comprising one or more solubilizers.
4. The sunscreen composition of claim 3, wherein the one or more solubilizing agents are selected from the group consisting of: diisopropyl sebacate, dioctyl carbonate, decyl cocoate, diisopropyl adipate, isopropyl lauroyl sarcosinate, dibutyl adipate, butyl octyl salicylate, C12-15 alkyl benzoate, and diethyl ethylhexyl succinate.
5. The sunscreen composition of any one of claims 2-4, further comprising one or more emulsifiers.
6. A sunscreen cream composition according to claim 5, wherein the one or more emulsifiers are selected from polyglycerol 6 stearate, polyglycerol 6 behenate or potassium cetyl phosphate or vinyl acrylate neodecanoate crosspolymers.
7. The sunscreen composition of any one of claims 2-4, wherein
The UV-A filter comprises butyl methoxydibenzoylmethane;
the UV-B filter is selected from ethylhexyl triazone, octyl salicylate and isoamyl p-methoxycinnamate, diethylhexyl butamido triazone; and is
The broadband UV-A and UV-B filters include bis-ethylhexyloxyphenol methoxyphenyl triazine.
8. The sunscreen composition of any one of claims 1-7, wherein the UV filter composition comprises:
three UV-B filters;
a UV-A filter; and
UV-A + UV-B broadband filter.
9. The sunscreen composition according to any one of claims 2 to 4, wherein:
the UV-A light filter is butyl methoxydibenzoylmethane,
the UV-B filter is ethylhexyl triazone, octyl salicylate, diethyl hexyl butamido triazone, and
the broadband UV-A and UV-B light filter is bis-ethylhexyl oxyphenol methoxyphenyl triazine.
10. The sunscreen composition of claim 5, wherein the mass ratio of the UV-A filter to the UV-B filter to the broadband filter is about 2: 7: 1.
11. The sunscreen composition of claim 5, wherein the mass ratio of the UV-A filter to the UV-B filter to the broadband filter is about 4: 11: 2.
12. The sunscreen composition of claim 5, wherein the mass ratio of the UV-A filter to the UV-B filter to the broadband filter is about 4: 13: 2.
13. The sunscreen composition according to any one of claims 2 to 12, wherein the composition comprises from about 8% to about 10% of a solubilizer.
14. The sunscreen composition of any one of claims 2-12, wherein the composition comprises from about 8% to about 10% film former.
15. The sunscreen composition according to any one of claims 2 to 12, wherein the UV-B filter, UV-a filter, and UV-a + UV-B broadband filter together range from about 5 wt% to about 25 wt% of the sunscreen composition.
16. A method for protecting skin from the sun, the method comprising applying to the skin a sunscreen composition according to any one of claims 2-14.
CN202080080833.7A 2019-11-20 2020-11-19 Sunscreen compositions with multiple photoprotective UV filters Pending CN114746070A (en)

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