CN114739996A - Disposable virus detection device - Google Patents
Disposable virus detection device Download PDFInfo
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- CN114739996A CN114739996A CN202210204216.4A CN202210204216A CN114739996A CN 114739996 A CN114739996 A CN 114739996A CN 202210204216 A CN202210204216 A CN 202210204216A CN 114739996 A CN114739996 A CN 114739996A
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- 238000001514 detection method Methods 0.000 title claims abstract description 83
- 241000700605 Viruses Species 0.000 title claims abstract description 40
- 230000003321 amplification Effects 0.000 claims abstract description 88
- 238000003199 nucleic acid amplification method Methods 0.000 claims abstract description 88
- 238000007789 sealing Methods 0.000 claims abstract description 73
- 239000012528 membrane Substances 0.000 claims abstract description 12
- 239000012530 fluid Substances 0.000 claims description 99
- 239000007788 liquid Substances 0.000 claims description 47
- 239000002699 waste material Substances 0.000 claims description 46
- 238000002347 injection Methods 0.000 claims description 24
- 239000007924 injection Substances 0.000 claims description 24
- 230000003287 optical effect Effects 0.000 claims description 13
- 230000005540 biological transmission Effects 0.000 claims description 8
- 239000003153 chemical reaction reagent Substances 0.000 claims description 6
- VWDWKYIASSYTQR-UHFFFAOYSA-N sodium nitrate Chemical compound [Na+].[O-][N+]([O-])=O VWDWKYIASSYTQR-UHFFFAOYSA-N 0.000 claims description 6
- 239000000243 solution Substances 0.000 claims description 5
- 238000007499 fusion processing Methods 0.000 claims description 3
- 235000010344 sodium nitrate Nutrition 0.000 claims description 3
- 239000004317 sodium nitrate Substances 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 239000011550 stock solution Substances 0.000 abstract description 28
- 238000010586 diagram Methods 0.000 description 8
- 238000000034 method Methods 0.000 description 5
- 230000000694 effects Effects 0.000 description 4
- 238000012545 processing Methods 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000003014 reinforcing effect Effects 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/84—Systems specially adapted for particular applications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
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Abstract
The invention provides a disposable virus detection device, comprising: a piston member, a main housing sealing member, a main housing sealing member, an AMP amplification chamber sealing member, and an AMP flow path member, the bottom end of the piston element is slidably provided with the main shell sealing membrane, compared with the traditional virus detection device, the device can quickly and stably detect the internal virus stock solution when in use, the integral detection mode is simpler, the convenience of the equipment in use is greatly improved, the accuracy of the final detection data is ensured, thereby great improvement the operating mass of equipment self, guaranteed the result of use of whole part, can also detect and control the position of internal part and stoste, it is more convenient when using to let equipment, also can not lead to the condition that the detection data of equipment self appears the mistake because of the existence of other factors to this auxiliary assembly is stable detects.
Description
Technical Field
The invention relates to the technical field of virus detection, in particular to a disposable virus detection device.
Background
Most of viruses are formed by the pollution of the surrounding environment or the spread of harmful substances, the existing virus detection technology is very mature, and can detect various viruses, but the existing virus detection equipment has a complex structure, and needs to be thoroughly cleaned after being used every time, a large amount of working time needs to be consumed, and the equipment is low in utilization rate and popularization rate because the self cost is high, so that the virus detection equipment is very troublesome, and the detection speed and the detection efficiency are influenced.
Therefore, there is a need to provide a new disposable virus detection device to solve the above technical problems.
Disclosure of Invention
In order to solve the technical problem, the invention provides a disposable virus detection device which is convenient to carry and can be used for rapid detection.
The disposable virus detection device provided by the invention comprises: the AMP amplification chamber sealing element is arranged at the bottom end of the main shell sealing element, the AMP amplification chamber sealing element is arranged at the bottom end of the main shell sealing element, the AMP amplification chamber sealing film is arranged at the bottom end of the AMP amplification chamber sealing element, the AMP flow channel element is arranged between the AMP amplification chamber sealing element and the AMP amplification chamber sealing film, the top end of the main shell is fixedly provided with a main shell cover, the side surface of the main shell is fixedly provided with a detection device, the bottom end of the main shell is slidably provided with a control device, the control device is connected with the main shell sealing element in a sliding way, and the bottom end of the AMP amplification chamber sealing element is provided with an amplification device, the amplification device is rotatably connected to the AMP flow channel element.
Preferably, the main housing further comprises an outer case, a fluid reservoir, a fluid outlet, an exhaust hole, a chip mounting groove, a grating window, a sample storage chamber, a cross-shaped taper needle, a waste liquid storage chamber and an extension boss, the bottom end of the main shell sealing film is provided with an outer shell, a fluid storage chamber is arranged in the outer shell, fluid outlets are arranged at the bottom end of the fluid storage chamber at equal intervals, the main shell is provided with an exhaust hole on the side surface of the outer shell, a chip mounting groove is arranged on one side of the inner part of the outer shell far away from the fluid storage chamber, a waste liquid storage chamber is arranged on the side surface of the chip mounting groove in the outer shell, a grating window is arranged on the outer side in the outer shell, the inside sample apotheca of having seted up that is located grating window side of shell, the inside fixed mounting of sample apotheca has the cross awl needle, shell bottom surface equidistance fixed mounting has the extension boss.
Preferably, the fluid reservoirs are divided into three sizes in total: the device comprises a large storage chamber, a medium-sized storage chamber and a small storage chamber, wherein the capacity of the large storage chamber is not less than 4000 mu l, the capacity of the small storage chamber is not less than 2000 mu l, the capacity of the small storage chamber is not less than 200 mu l, and not less than two fluid storage chambers are not less than one large storage chamber and not less than 4000 mu l of super clean water is stored in the large storage chamber; not less than one GE of the large storage chamber stores not less than 4000 μ l of sodium nitrate solution.
Preferably, main casing lid includes main casing lid, perforation, piston injection chamber window, infrared ray sensor window, sample storage window, awl needle, fixture block and draw-in groove, the outside slidable mounting of piston element has main casing lid, the inside piston injection chamber window of having seted up of main casing lid, piston injection chamber window and piston element sliding connection, main casing lid surface equidistance has seted up the perforation, the infrared ray sensor window has been seted up to the inside one side of main casing lid, the inside infrared ray sensor window that is located of main casing lid has seted up the sample storage window to the side, main casing lid bottom equidistance fixed mounting has the awl needle, main casing lid bottom symmetry fixed mounting has the fixture block, the inside draw-in groove of having seted up in the fixture block bottom that is located of main casing, fixture block and draw-in groove cooperation joint.
Preferably, the inside position that corresponds sealed hole of main casing body seal component has seted up the recess, 2mm is no less than to the degree of depth of its recess, and the position fixed mounting that the main casing body seal component bottom back corresponds sealed hole has the boss, 0.2mm is no less than to the height of its boss, in use can cooperate the rotation and the regulation of follow-up equipment internal component, let the frictional force between the part reduce, thereby the life of part has been guaranteed, make the work quality of equipment self more perfect, later utilize inside recess, can effectual reinforcing main casing body seal component self the leakproofness, prevent that external impurity from getting into inside the equipment, make equipment can not appear the condition that detects the data error because of external factor in the testing process, the accuracy of final detection data has been guaranteed.
Preferably, the detection device comprises a detection chip, a detection area channel element, a lens mounting groove, a hexagonal hole inner wall, an optical lens, a reagent reaction area, a waste liquid storage chamber cover, a light transmission window, a waste liquid storage groove and a waste liquid channel switch valve window, wherein the detection chip is slidably mounted on the surface of the main shell, the detection area is fixedly mounted in the detection chip, the detection area channel element is fixedly mounted at the top end of the main shell, the lens mounting groove is formed in the detection area channel element, the hexagonal hole groove is formed in the detection area channel element and is positioned at the bottom end of the lens mounting groove, the hexagonal hole inner wall is provided with the hexagonal hole inner wall, the optical lens is fixedly mounted in the lens mounting groove, the waste liquid storage chamber cover is fixedly mounted at the side surface of the detection area channel element at the top end of the main shell, the inside light transmission window of having seted up of waste liquid storage chamber cap, the inside waste liquid hold up tank that has located the light transmission window side of waste liquid storage chamber cap, the inside waste liquid hold up tank side that is located of waste liquid hold up tank has seted up waste liquid runner ooff valve window.
Preferably, the amplification device comprises a base, an AMP amplification groove fluid inlet, an AMP amplification groove fluid outlet and an AMP amplification groove, the base is arranged at the bottom end of the AMP amplification chamber sealing element, AMP amplification grooves are formed in the base at equal intervals, one side of the AMP amplification groove is fixedly provided with the AMP amplification groove fluid inlet at equal intervals, the other side of the AMP amplification groove is fixedly provided with the AMP amplification groove fluid outlet at equal intervals, and in use, stock solution in the device is conveyed into the AMP amplification groove through the AMP amplification groove fluid inlet.
Preferably, the AMP amplification chamber sealing film has a film thickness of 0.05-0.2mm and is attached to the bottom of the amplification apparatus by a laser fusion process.
Preferably, controlling means includes control valve, piston injection cavity, fluid flow way, the outer port of first fluid, the outer port of second fluid, exhaust passage and rotary joint, main casing body sealing element bottom slidable mounting has the control valve, the inside piston injection cavity of having seted up of control valve, the inside piston injection cavity side that is located of control valve has seted up fluid flow way, the inside fluid flow way top equidistance that is located of control valve has seted up the outer port of second fluid, the inside outer port of first fluid of having seted up of the outer port bottom equidistance of second fluid that is located of control valve, the inside exhaust passage of having seted up of the inboard equidistance of the outer port of second fluid that is located of control valve, the rotary joint is installed in the rotation of control valve top.
Preferably, grating gaps are equidistantly formed in the outer portion of the control valve, the width of each grating gap is 0.2-0.6 mm, 34 groups of grating gaps are arranged, and each grating gap is 10 degrees away.
Preferably, the bottom of each fluid storage chamber is provided with a diversion inclined platform so as to facilitate the concentrated flow of the fluid to the fluid outlet; the surfaces of the first fluid outer port, the second fluid outer port and the port of the exhaust channel are all provided with bulges, the heights of the bulges are not less than 0.2mm, and the bulges are used for being tightly attached to the sealing element of the main shell and the sealing element of the AMP amplification chamber.
Compared with the related art, the disposable virus detection device provided by the invention has the following beneficial effects:
the invention provides a disposable virus detection device:
1. by using the detection device, the internal virus stock solution can be quickly and stably detected, so that the integral detection mode is simpler and more convenient, the convenience of the equipment in use is greatly improved, and the accuracy of final detection data is ensured, so that the working quality of the equipment is greatly improved, and the use effect of integral parts is ensured;
2. through the use of the main shell cover, the amplification device and the control device, the positions of internal parts and stock solution can be detected and controlled, so that the equipment is more convenient to use, and the condition that errors occur in the detection data of the equipment due to the existence of other factors is avoided, thereby stably detecting the auxiliary equipment.
Drawings
FIG. 1 is a schematic view of an overall structure provided by the present invention;
FIG. 2 is a second schematic view of the overall structure provided by the present invention;
FIG. 3 is a third schematic view of the overall structure provided by the present invention;
FIG. 4 is a schematic structural diagram of the main housing provided by the present invention;
FIG. 5 is a schematic view of a main housing cover structure according to the present invention;
FIG. 6 is a second schematic view of the main housing cover structure provided by the present invention;
FIG. 7 is a schematic structural diagram of a detecting device according to the present invention;
FIG. 8 is a second schematic structural diagram of a detecting device according to the present invention;
FIG. 9 is a schematic view of an amplification apparatus according to the present invention;
FIG. 10 is a second schematic view of the amplification apparatus according to the present invention;
FIG. 11 is a schematic structural diagram of a control device according to the present invention;
FIG. 12 is a schematic view of a cross-sectional structure of C-C in the schematic view provided by the present invention.
Reference numbers in the figures: 1. a piston element; 2. a main housing seal film; 3. a main housing; 31. a housing; 32. a fluid reservoir; 33. a fluid outlet; 34. an exhaust hole; 35. a chip mounting groove; 36. a grating window; 37. a sample storage chamber; 38. a cross-shaped conical needle; 39. a waste liquid storage chamber; 310. an extension boss; 4. a main housing seal member; 5. an AMP amplification chamber sealing member; 6. sealing the AMP amplification chamber; 7. an AMP flow channel element; 8. a main shell cover; 81. a main housing cover; 82. perforating; 83. a piston injection chamber window; 84. an infrared sensor window; 85. a sample storage window; 86. a conical needle; 87. a clamping block; 88. a card slot; 9. a detection device; 91. detecting a chip; 92. detecting a region; 93. a detection zone flow channel element; 94. a lens mounting groove; 95. a hexagonal hole groove; 96. the inner wall of the hexagonal hole groove; 97. an optical lens; 98. a reagent reaction zone; 99. a waste liquid storage chamber cover; 910. a light transmissive window; 911. a waste liquid storage tank; 912. a waste liquid channel switch valve window; 10. an amplification device; 101. a base; 102. an AMP amplification chamber fluid inlet; 103. an AMP amplification chamber fluid outlet; 104. an AMP amplification chamber; 11. a control device; 111. a control valve; 112. a piston injection chamber; 113. a fluid flow passage; 114. a first fluid out port; 115. a second fluid outer port; 116. an exhaust passage; 117. a rotating joint; 118. a flow guiding inclined table.
Detailed Description
The invention is further described with reference to the following figures and embodiments.
Please refer to fig. 1, fig. 2, fig. 3, fig. 4, fig. 5, fig. 6, fig. 7, fig. 8, fig. 9, fig. 10 and fig. 11 in combination, wherein fig. 1 is one of the overall structural diagrams provided by the present invention; FIG. 2 is a second schematic view of the overall structure provided by the present invention; FIG. 3 is a third schematic view of the overall structure provided by the present invention; FIG. 4 is a schematic view of the main housing of the present invention; FIG. 5 is a schematic view of a main cover structure according to the present invention; FIG. 6 is a second schematic view of the main housing cover structure provided by the present invention; FIG. 7 is a schematic structural diagram of a detecting device according to the present invention; FIG. 8 is a second schematic structural diagram of a detecting device according to the present invention; FIG. 9 is a schematic view of an amplification apparatus according to the present invention; FIG. 10 is a second schematic view of the amplification apparatus according to the present invention; FIG. 11 is a schematic structural diagram of a control device according to the present invention; FIG. 12 is a schematic view of a cross-sectional structure of C-C in the schematic view provided by the present invention.
A single-use virus detection device comprising: a piston member 1, a main housing sealing film 2, a main housing 3, a main housing sealing member 4, an AMP amplification chamber sealing member 5, an AMP amplification chamber sealing film 6, and an AMP flow path member 7.
In a specific implementation process, as shown in fig. 1, 2 and 3, a main housing sealing film 2 is slidably mounted at a bottom end of a piston element 1, a main housing 3 is disposed at a bottom end of the piston element 1, a main housing sealing element 4 is slidably mounted at a bottom end of the main housing 3, an AMP amplification chamber sealing element 5 is disposed at a bottom end of the main housing sealing element 4, an AMP amplification chamber sealing film 6 is disposed at a bottom end of the AMP amplification chamber sealing element 5, an AMP flow channel element 7 is disposed between the AMP amplification chamber sealing element 5 and the AMP amplification chamber sealing film 6, a main housing cover 8 is fixedly mounted at a top end of the main housing 3, a detection device 9 is fixedly mounted at a side surface of the main housing 3, a control device 11 is slidably mounted at a bottom end of the main housing 3, the control device 11 is slidably connected with the main housing sealing element 4, and an amplification device 10 is disposed at a bottom end of the AMP amplification chamber sealing element 5, the amplification device 10 is rotatably connected to the AMP flow channel element 7.
In use, the equipment is placed at a target position, then the external virus stock solution is quickly adsorbed into the main shell 3 through the use of the main shell cover 8, then the stock solution flows and is controlled through the matching of the components in the main shell 3, and because the control device 11 is used for controlling the flow path of the stock solution, the equipment can be stably controlled, then the internal stock solution is stored and adsorbed through the use of the amplification device 10, and then the internal stock solution is sealed and controlled through the use of the AMP amplification chamber sealing membrane 6, and then the internal virus stock solution is detected through the use of the detection device 9, so that the whole processing flow is more convenient and stable, the internal stock solution can be controlled during detection, the working quality of the equipment and the accuracy of finally detected data are greatly improved, the equipment is more convenient to use in the subsequent process.
Referring to fig. 4, the main housing 3 further includes an outer housing 31, a fluid reservoir 32, a fluid outlet 33, an air vent 34, a chip mounting groove 35, a grating window 36, a sample reservoir 37, a cross-shaped taper pin 38, a waste liquid reservoir 39 and an extension boss 310, the outer housing 31 is disposed at the bottom end of the main housing sealing film 2, the fluid reservoir 32 is disposed inside the outer housing 31, the fluid outlet 33 is disposed at the bottom end of the fluid reservoir 32 in an equal distance, the air vent 34 is disposed at the side of the outer housing 31 inside the main housing 3, the chip mounting groove 35 is disposed at one side of the outer housing 31 away from the fluid reservoir 32, the waste liquid reservoir 39 is disposed at one side of the chip mounting groove 35 inside the outer housing 31, the grating window 36 is disposed at the outside of the outer housing 31, the sample reservoir 37 is disposed at the side of the grating window 36 inside the outer housing 31, the cross-shaped taper pin 38 is fixedly disposed inside the sample reservoir 37, the bottom end surface of the shell 31 is fixedly provided with extending bosses 310 at equal intervals.
In use is through piston element 1's use, draw outside virus stoste, then use through fluid storeroom 32, virus stoste to inside is saved, later use through fluid outlet 33, carry inside stoste, later use through exhaust hole 34 and AMP runner component 7, carry the stoste inside detection device 9, make things convenient for follow-up detection device 9 to detect it, the stoste is producing the reaction rather than behind the chip, the reaction that can observe on the chip reachs this virus kind, and store to waste liquid storeroom 39 after finishing detecting, collect the waste liquid, avoid the pollution to reveal and lead to infecting the risk, make the use of equipment more stable safety.
Referring to fig. 4, the fluid reservoirs 32 are divided into three sizes: the device comprises a large storage chamber, a medium-sized storage chamber and a small storage chamber, wherein the capacity of the large storage chamber is not less than 4000 mu l, the capacity of the small storage chamber is not less than 2000 mu l, the capacity of the small storage chamber is not less than 200 mu l, and not less than two fluid storage chambers are not less than one large storage chamber and not less than 4000 mu l of super clean water is stored in the large storage chamber; not less than one GE of the large storage chamber stores not less than 4000 μ l of sodium nitrate solution.
In use can come adjustment fluid storeroom 32 self size according to the demand of self, guarantees to absorb more stostes and detects, guarantees the stability of the final detected data of equipment, to the used demand of different needs reagent, stores reagent with reasonable size, reducible overall cost and virus detection device size, and makes the equipment to the variety that the pathogen detected, ensures to analyze out the viral species of its infection. Referring to fig. 5 and 6, the main housing cover 8 includes a main housing cover 81, through holes 82, a piston injection chamber window 83, an infrared sensor window 84, a sample storage window 85, a conical needle 86, a latch 87, and a latch 88, the main housing cover 81 is slidably mounted outside the piston element 1, the piston injection chamber window 83 is formed inside the main housing cover 81, the piston injection chamber window 83 is slidably connected to the piston element 1, the through holes 82 are formed on the surface of the main housing cover 81 at equal intervals, the infrared sensor window 84 is formed on one side inside the main housing cover 81, the sample storage window 85 is formed inside the main housing cover 81 on the side of the infrared sensor window 84, the conical needles 86 are fixedly mounted at equal intervals at the bottom end of the main housing cover 81, the latch 87 is fixedly mounted at the bottom end of the main housing cover 81 symmetrically, the latch 88 is formed inside the main housing 3 at the bottom end of the latch 87, the latch 87 is matched and clamped with the clamping groove 88.
In use, external stock solution can be conveyed to the interior of the main shell 3 through the use of the piston injection chamber window 83, and due to the existence of the fluid storage chamber 32, the piston element 1 is more convenient to use, then a sample is stored in the interior of the sample storage window 85, then the sensor is installed at a target position through the use of the infrared sensor window 84, the sensor can be rapidly detected, so that the integral processing quality is ensured, and the device of the main shell cover 8 can be better matched with the main shell sealing film 2.
Referring to fig. 1 and 3, a groove is formed in the main casing sealing element 4 at a position corresponding to the sealing hole, the depth of the groove is not less than 2mm, a boss is fixedly mounted on the back of the bottom end of the main casing sealing element 4 at a position corresponding to the sealing hole, and the height of the boss is not less than 0.2 mm.
In use, the rotation and the regulation of follow-up equipment internal components can be matched, the friction force between the components is reduced, the service life of the components is ensured, the working quality of the equipment is more perfect, then, the internal groove is utilized, the sealing performance of the main shell sealing element 4 can be effectively enhanced, external impurities are prevented from entering the equipment, the condition of data detection errors caused by external factors can be avoided in the detection process of the equipment, and the accuracy of final detection data is ensured.
Referring to fig. 7 and 8, the detecting device 9 includes a detecting chip 91, a detecting area 92, a detecting area flow channel element 93, a lens mounting groove 94, a hexagonal hole groove 95, a hexagonal hole inner wall 96, an optical lens 97, a reagent reaction area 98, a waste liquid storage chamber cover 99, a light-transmitting window 910, a waste liquid storage groove 911, and a waste liquid flow channel switch valve window 912, the detecting chip 91 is slidably mounted on the surface of the main housing 3, the detecting area 92 is fixedly mounted inside the detecting chip 91, the detecting area flow channel element 93 is fixedly mounted at the top end of the main housing 3, the lens mounting groove 94 is formed inside the detecting area flow channel element 93, the hexagonal hole groove 95 is formed inside the detecting area flow channel element 93 at the bottom end of the lens mounting groove 94, the hexagonal hole inner wall 96 is formed on the inner wall of the hexagonal hole groove 95, the optical lens 97 is fixedly mounted inside the lens mounting groove 94, 3 tops of main casing body are located detection zone runner component 93 side fixed mounting has waste liquid storage chamber cap 99, the inside light transmission window 910 of having seted up of waste liquid storage chamber cap 99, waste liquid storage chamber cap 99 is inside to be located light transmission window 910 side and has seted up waste liquid hold up 911, waste liquid storage chamber cap 99 is inside to be located waste liquid hold up 911 side and has seted up waste liquid runner ooff valve window 912.
In use is through carrying detection chip 91 with the stoste, later the stoste forms the reaction on the detection area 92 surface on detection chip 91, detect the composition of stoste, and because optical lens 97's use, can observe detection area 92, make it can more conveniently cooperate optical microscope to observe its reaction degree, because light-transmitting window 910's use again, can guarantee the position of optical lens 97 on equipment, inside can directly carry waste liquid hold up tank 911 behind the stoste through detection area 92, prevent that the stoste from revealing, cause the pollution to surrounding environment and equipment, thereby the operating mass of equipment self has been guaranteed.
Referring to fig. 9 and 10, the amplification device 10 includes a base 101, an AMP amplification chamber fluid inlet 102, an AMP amplification chamber fluid outlet 103, and an AMP amplification chamber 104, the base 101 is disposed at the bottom end of the AMP amplification chamber sealing member 5, the AMP amplification chamber 104 is equidistantly disposed in the base 101, the AMP amplification chamber fluid inlet 102 is equidistantly and fixedly disposed at one side of the AMP amplification chamber 104, and the AMP amplification chamber fluid outlet 103 is equidistantly and fixedly disposed at the other side of the AMP amplification chamber 104.
In use, the original liquid in the equipment is conveyed to the AMP amplification groove 104 by using the fluid inlet 102 of the AMP amplification groove, and when other conditions are met, the original liquid in the equipment can flow out by using the fluid outlet 103 of the AMP amplification groove, so that the purpose of amplifying the internal storage space is achieved, the equipment is more convenient to use, too much original liquid can be collected, and the working quality of the equipment is more perfect.
Referring to FIG. 1, the AMP chamber sealing film 6 has a film thickness of 0.05-0.2mm and is attached to the bottom of the amplification apparatus 10 by a laser fusion process.
It is known through the experiment that once AMP amplifies the room and seals the great back of membrane 6 self thickness, can lead to the fact certain influence to AMP amplifies the room and seals the heating of membrane 6 inside, through continuous adjustment, can guarantee once AMP amplifies the room and seals membrane 6 thickness guarantee when between 0.05-0.2mm, can guarantee that AMP amplifies the room and seal membrane 6 self thickness and can not lead to the fact the influence to the heating effect of amplification device 10 self, guarantee the degree of accuracy of final detection data.
Referring to fig. 11, the control device 11 includes a control valve 111, a piston injection chamber 112, a fluid flow channel 113, a first fluid external port 114, a second fluid external port 115, an exhaust channel 116, and a rotary joint 117, the control valve 111 is slidably installed at the bottom end of the main casing sealing element 4, the piston injection chamber 112 is opened inside the control valve 111, the fluid flow channel 113 is opened inside the control valve 111 at the side of the piston injection chamber 112, the second fluid external port 115 is opened inside the control valve 111 at the top end of the fluid flow channel 113 at an equal distance, the first fluid external port 114 is opened inside the control valve 111 at the bottom end of the second fluid external port 115 at an equal distance, the exhaust channel 116 is opened inside the control valve 111 at the inner side of the second fluid external port 115 at an equal distance, and the rotary joint 117 is rotatably installed at the top end of the control valve 111.
In use, through the use of the piston element 1, the external stock solution directly enters the piston injection chamber 112, then the inside is heated through the use of the bottom end amplification device 10, then the gas in the inside is discharged through the use of the exhaust channel 116, and because of the use of the rotary joint 117, the flow direction of the internal stock solution can be selected, the use effect of subsequent equipment is ensured, and because of the use of the upper end infrared inductor, the position of the internal control valve 111 can be confirmed, so that the use of the device is more stable and convenient.
Referring to fig. 2, grating notches are equidistantly formed in the exterior of the control valve 111, the width of each grating notch is 0.2-0.6 mm, 34 groups of grating notches are arranged, and each grating notch is spaced by 10 degrees.
Referring to fig. 1, 2, 3, 4, 11 and 12, the bottoms of the fluid storage chambers 32 are provided with diversion ramps to facilitate the concentrated flow of fluid to the fluid outlets 33; the port surfaces of the first fluid external port 114, the second fluid external port 115 and the exhaust channel 116 are all provided with protrusions with the height not less than 0.2mm, and are used for being tightly attached to the main casing sealing element 4 and the AMP amplification chamber sealing element 5, and the contact area during rotation can be reduced due to the protrusion arrangement, so that the friction force is reduced.
In use, the grating notch is used, and the position of the internal control valve 111 is detected and controlled in real time by matching with the use of the upper end infrared sensor, so that the equipment is more stable and convenient to use.
The working principle is as follows: when the disposable virus detection device is used, the device is placed at a target position, then external virus stock solution is quickly absorbed into the main shell 3 through the use of the main shell cover 8, the external stock solution can be conveyed into the main shell 3 through the use of the piston injection cavity window 83, the use of the piston element 1 is more convenient because of the existence of the fluid storage chamber 32, then a sample is stored in the sample storage window 85, then the sensor is installed at the target position through the use of the infrared sensor window 84, the detection can be quickly carried out, the integral processing quality is ensured, the device of the main shell cover 8 can be better matched with the main shell sealing film 2, then the stock solution flows and is controlled through the matching of the components in the main shell 3, and through the use of the piston element 1, the external virus stock solution is sucked, then the internal virus stock solution is stored through the use of the fluid storage chamber 32, then the internal stock solution is conveyed through the use of the fluid outlet 33, then the stock solution is conveyed into the detection device 9 through the use of the exhaust hole 34 and the AMP flow channel element 7, the subsequent detection device 9 is convenient to detect, and the waste solution can be collected through the use of the waste solution storage chamber 39 after the detection is finished, the stability of the device is ensured, the pollution caused by exposure is avoided, the use of the device is more convenient and safer, and because the control device 11 is used for controlling the flow path of the stock solution, the device can be stably controlled, the external stock solution directly enters the piston injection chamber 112 through the use of the piston element 1, and then the bottom end amplification device 10 is used, the interior is heated, then the gas in the interior is discharged through the use of the exhaust channel 116, and the flow direction of the interior stock solution can be selected due to the use of the rotary joint 117, so that the use effect of subsequent equipment is ensured, and the position of the interior control valve 111 can be confirmed due to the use of the upper end infrared sensor, so that the use of the device is more stable and convenient, then the interior stock solution is stored and adsorbed through the use of the amplification device 10, the stock solution in the interior of the equipment is conveyed to the interior of the AMP amplification tank 104 through the use of the fluid inlet 102 of the AMP amplification tank, when other conditions are met, the interior stock solution can flow out through the use of the fluid outlet 103 of the AMP amplification tank, so that the purpose of amplifying the interior storage space is achieved, the equipment is more convenient to use, too much stock solution can be collected, and the working quality of the equipment is more perfect, and then through the use of AMP amplification chamber seal membrane 6, seal and control the inside stoste, then through the use of detection device 9, detect the virus stoste inside, through sending the stoste to detect chip 91, then the stoste forms the reaction on detecting area 92 surface on detecting chip 91, detect the composition of the stoste, and because of the use of optical lens 97, can observe detecting area 92, make it can cooperate with the optical microscope to observe its reaction degree more conveniently, make the apparatus more convenient when using, because of the use of the light-transmitting window 910, can guarantee optical lens 97 more convenient when using, after detecting, the inside stoste is carried to the inside of the waste liquid storage tank 911 directly, prevent the stoste from revealing, cause the pollution to surrounding environment and apparatus, thus has guaranteed the working quality of the apparatus itself, the working quality of the equipment and the accuracy of finally detected data are greatly improved, and the equipment is more convenient and faster in subsequent use.
The above description is only an embodiment of the present invention, and not intended to limit the scope of the present invention, and all modifications of equivalent structures and equivalent processes, which are made by using the contents of the present specification and the accompanying drawings, or directly or indirectly applied to other related technical fields, are included in the scope of the present invention.
Claims (10)
1. A single-use virus detection device comprising: piston element (1), main casing seal membrane (2), main casing (3), main casing sealing element (4), AMP amplify room sealing element (5), AMP and amplify room and seal membrane (6) and AMP runner component (7), piston element (1) bottom slidable mounting has main casing sealing membrane (2), piston element (1) bottom is provided with main casing (3), main casing sealing element (4) is installed to main casing (3) bottom slidable mounting, main casing sealing element (4) bottom is provided with AMP and amplify room sealing element (5), AMP amplifies room sealing element (5) bottom and is provided with AMP and amplify room and seal membrane (6), AMP amplifies room sealing element (5) and AMP and amplify and be provided with AMP runner element (7) between room sealing membrane (6), its characterized in that: the utility model discloses a AMP amplification chamber sealing element, including main casing body (3), main casing body (3) top fixed mounting has main cap (8), main casing body (3) side fixed mounting has detection device (9), main casing body (3) bottom slidable mounting has controlling means (11), controlling means (11) and main casing body sealing element (4) sliding connection, AMP amplification chamber sealing element (5) bottom is provided with amplification device (10), amplification device (10) are connected with AMP runner component (7) rotation.
2. The disposable virus detection device according to claim 1, wherein the main housing (3) further comprises an outer housing (31), a fluid storage chamber (32), a fluid outlet (33), an air vent (34), a chip mounting groove (35), a grating window (36), a sample storage chamber (37), a cross-shaped taper needle (38), a waste liquid storage chamber (39) and an extension boss (310), the outer housing (31) is disposed at the bottom end of the main housing sealing film (2), the fluid storage chamber (32) is disposed inside the outer housing (31), the fluid outlet (33) is disposed at the bottom end of the fluid storage chamber (32) with equal distance, the air vent (34) is disposed at the side of the outer housing (31) inside the main housing (3), the chip mounting groove (35) is disposed at one side of the outer housing (31) far from the fluid storage chamber (32), the waste liquid storage chamber (39) is disposed at the side of the chip mounting groove (35) inside the outer housing (31), grating window (36) have been seted up in the inside outside of shell (31), sample storage chamber (37) have been seted up to inside being located grating window (36) side of shell (31), the inside fixed mounting of sample storage chamber (37) has cross awl needle (38), shell (31) bottom surface equidistance fixed mounting has extension boss (310).
3. A single-use virus detection device according to claim 2, wherein the fluid reservoir (32) is divided into three sizes in total: the device comprises a large storage chamber, a medium-sized storage chamber and a small storage chamber, wherein the capacity of the large storage chamber is not less than 4000 mu l, the capacity of the small storage chamber is not less than 2000 mu l, the capacity of the small storage chamber is not less than 200 mu l, and not less than two fluid storage chambers are not less than one large storage chamber and not less than 4000 mu l of super clean water is stored in the large storage chamber; not less than one GE of the large storage chamber stores not less than 4000 μ l of sodium nitrate solution.
4. The disposable virus detection device according to claim 1, wherein the main housing cover (8) comprises a main housing cover (81), a through hole (82), a piston injection chamber window (83), an infrared sensor window (84), a sample storage window (85), a conical needle (86), a fixture block (87) and a fixture groove (88), the main housing cover (81) is slidably mounted outside the piston element (1), the piston injection chamber window (83) is formed inside the main housing cover (81), the piston injection chamber window (83) is slidably connected with the piston element (1), the through holes (82) are formed on the surface of the main housing cover (81) at equal intervals, the infrared sensor window (84) is formed on one side inside the main housing cover (81), the sample storage window (85) is formed on the side of the infrared sensor window (84) inside the main housing cover (81), main casing body lid (81) bottom equidistance fixed mounting has awl needle (86), main casing body lid (81) bottom symmetry fixed mounting has fixture block (87), main casing body (3) inside is located fixture block (87) bottom and has seted up draw-in groove (88), fixture block (87) and draw-in groove (88) cooperation joint.
5. The disposable virus detection device according to claim 1, wherein a groove is formed in the main housing sealing element (4) at a position corresponding to the sealing hole, the depth of the groove is not less than 2mm, a boss is fixedly mounted on the back of the bottom end of the main housing sealing element (4) at a position corresponding to the sealing hole, and the height of the boss is not less than 0.2 mm.
6. The disposable virus detection device according to claim 4, wherein the detection device (9) comprises a detection chip (91), a detection area (92), a detection area flow channel element (93), a lens mounting groove (94), a hexagonal hole groove (95), a hexagonal hole groove inner wall (96), an optical lens (97), a reagent reaction area (98), a waste liquid storage chamber cover (99), a light transmission window (910), a waste liquid storage groove (911) and a waste liquid flow channel switch valve window (912), the detection chip (91) is slidably mounted on the surface of the main housing (3), the detection area (92) is fixedly mounted inside the detection chip (91), the detection area flow channel element (93) is fixedly mounted at the top end of the main housing (3), the lens mounting groove (94) is formed inside the detection area flow channel element (93), the hexagonal hole groove (95) is formed inside the detection area flow channel element (93) at the bottom end of the lens mounting groove (94), hexagonal hole groove (95) inner wall is provided with hexagonal hole inslot wall (96), the inside fixed mounting of lens mounting groove (94) has optical lens (97), main casing body (3) top is located detection zone runner component (93) side fixed mounting has waste liquid storage chamber cap (99), inside light transmission window (910) of having seted up of waste liquid storage chamber cap (99), waste liquid storage chamber cap (99) inside is located light transmission window (910) side and has seted up waste liquid storage tank (911), waste liquid storage chamber cap (99) inside is located waste liquid storage tank (911) side and has seted up waste liquid runner ooff valve window (912).
7. The single-use virus detection device according to claim 1, wherein the amplification device (10) comprises a base (101), an AMP amplification chamber fluid inlet (102), an AMP amplification chamber fluid outlet (103), and an AMP amplification chamber (104), the base (101) is disposed at the bottom end of the AMP amplification chamber sealing member (5), the AMP amplification chamber (104) is disposed in the base (101) at an equal interval, the AMP amplification chamber fluid inlet (102) is fixedly disposed at one side of the AMP amplification chamber (104) at an equal interval, and the AMP amplification chamber fluid outlet (103) is fixedly disposed at the other side of the AMP amplification chamber (104) at an equal interval.
8. The single-use virus detection device according to claim 1, wherein the AMP amplification chamber sealing film (6) has a film thickness of 0.05-0.2mm and is attached to the bottom of the amplification device (10) by a laser fusion process.
9. The disposable virus detection device according to claim 2, wherein the control device (11) comprises a control valve (111), a piston injection chamber (112), a fluid channel (113), a first fluid outer port (114), a second fluid outer port (115), an exhaust channel (116) and a rotary joint (117), the control valve (111) is slidably mounted at the bottom end of the main housing sealing element (4), the piston injection chamber (112) is opened inside the control valve (111), the fluid channel (113) is opened inside the control valve (111) on the side of the piston injection chamber (112), the second fluid outer ports (115) are opened at the top end of the fluid channel (113) at equal intervals inside the control valve (111), the first fluid outer ports (114) are opened at the bottom end of the second fluid outer port (115) inside the control valve (111), exhaust channels (116) are formed in the control valve (111) and are positioned on the inner side of the outer port (115) of the second fluid at equal intervals, and a rotary joint (117) is rotatably installed at the top end of the control valve (111); the grating gaps are formed in the outer portion of the control valve (111) at equal intervals, the width of each grating gap is 0.2-0.6 mm, 34 groups of grating gaps are arranged in the grating gaps, and each grating gap is 10 degrees away.
10. The single-use virus detection device according to claim 9, wherein the fluid storage chambers (32) are each provided at the bottom with a flow-directing ramp (118) to facilitate the concentrated flow of fluid to the fluid outlet (33); the port surfaces of the first fluid external port (114), the second fluid external port (115) and the exhaust channel (116) are all provided with bulges, and the heights of the bulges are not less than 0.2mm, so that the first fluid external port, the second fluid external port and the exhaust channel are tightly attached to the main shell sealing element (4) and the AMP amplification chamber sealing element (5).
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| CN202210204216.4A CN114739996A (en) | 2022-03-02 | 2022-03-02 | Disposable virus detection device |
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| CN202210204216.4A CN114739996A (en) | 2022-03-02 | 2022-03-02 | Disposable virus detection device |
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