CN114736783A - Sample sampler for detecting infant mucosa gene - Google Patents

Abstract

The invention relates to a sample sampler for detecting genes of infant mucosa, which comprises an infant bed, a fixing bandage, a support, an adjusting frame, a sampling device, a cleaning module, a cleaning piece and a sealing layer, wherein the fixing bandage is installed in the middle of the infant bed, the upper end of the infant bed is slidably provided with the support, toys capable of making a bell sound are hung on the front side and the rear side of the upper end of the support, the adjusting frame is installed in the middle of the upper end of the support, the sampling device is installed at the lower end of the adjusting frame, the cleaning module is installed at the upper end of a built-in tank, the rotatable cleaning piece is arranged in the sealing cover, and the sealing layer is arranged at the opening position of a collecting frame.

Description

Sample sampler for detecting infant mucosa genes

Technical Field

The invention relates to the technical field of sampler correlation, in particular to a sampler for detecting infant mucosa genes.

Background

The gene detection is a technology for detecting DNA by blood, other body fluids or cells, which comprises the steps of taking peripheral venous blood or other tissue cells of a detected person, amplifying gene information, detecting DNA molecular information in the cells of the detected person by a specific device, and analyzing various conditions of the gene contained in the cells, so that people can know the gene information of the people, determine the etiology or predict the risk of a certain disease of the body, and the sampling and the detection of oral mucosa are important methods for gene detection.

In the existing sampling process, for example, chinese patent with publication number CN210287346U discloses a cell collector for gene detection, specifically, including an outer shell, which is characterized in that: the utility model discloses a cotton swab, including shell body, installation cavity, recess, pressing assembly, pushing assembly, outer shell, pushing assembly, collecting cavity, pushing assembly, outer shell, the installation cavity has been seted up to shell body inside, installation cavity front side middle part has been seted up in the middle part and has been dodged the groove relatively, the position that the groove below was dodged relatively to shell body front end middle part has been seted up and has been accomodate the groove, the position that the groove was dodged relatively to installation cavity rear side inner wall is provided with the promotion subassembly, it is provided with the pressing assembly to accomodate the inslot side, pressing assembly rear side upper end is connected with the inboard rotation of promotion subassembly lower extreme, through the upper and lower promotion to wood system cotton swab, gathers the oral cavity inside when releasing, inside the collection after-retracting installation cavity, avoids dust pollution.

In the prior art, the inner part of the oral cavity is scraped and then retracted into the mounting cavity through the wooden cotton swab, but the working mode is obviously unsuitable for oral cavity collection of infants, on the one hand, the infants have obvious conflict psychology on foreign matters plugged into the oral cavity, when the cotton swab is plugged into the oral cavity of the infants and stirred, the infants can only resist the foreign matters, but cannot cooperate with collection, and the crying infants bite the cotton swab stick or shake the head, so that collection personnel cannot easily see the condition in the oral cavity, and further normal collection is influenced, on the other hand, collection using a single cotton swab may have the phenomena of insufficient collection amount or collection position deviation, the occurrence of the phenomena can cause inaccurate detected data, and after the wooden cotton swab is retracted, the cotton swab part can scratch and rub with the surrounding mounting cavity, thereby reducing the amount of sample retained by the swab portion, and after the swab portion is retracted, the upper portion of the swab portion remains partially exposed to the environment, thereby causing contamination of the sample, thereby allowing room for improvement over existing collection techniques.

Disclosure of Invention

In order to reduce the conflict of infants during quick sampling, clean a sampler and collect samples in a sealing manner, the application specially provides a sample sampler for detecting infant mucosa genes.

The technical scheme is that the sample sampler for detecting the infant mucosa genes adopts the following technical scheme;

a sample sampler for detecting infant mucosal genes comprises an infant bed, wherein a fixing bandage is installed in the middle of the infant bed, a support is arranged at the upper end of the infant bed in a sliding mode, and toys capable of making small bell sounds are hung on the front side and the rear side of the upper end of the support;

the utility model discloses a sampling device, including support, sampling device, built-in jar, drive actuating cylinder, sampling head, rotation module, sampling layer, collection frame and sealed lid, the mid-mounting of support upper end has the alignment jig, sampling device is installed to the lower extreme of alignment jig, sampling device includes built-in jar, drives actuating cylinder, sampling head, rotation module, sampling layer, collection frame and sealed lid, the middle part of built-in jar is connected with slidable sampling head through driving actuating cylinder, and built-in jar is the feeding bottle shape, and the appearance of sampling head is the nipple shape, the middle part normal running fit of sampling head is provided with the rotation module, evenly be provided with the sampling layer along its circumference in the rotation module, the sampling layer is used for the sampling to the oral mucosa, the collection frame is installed to the lower extreme of built-in jar, and the cover is equipped with sealed lid on the sampling head.

By adopting the technical scheme, when in actual sampling, an infant is placed in an infant bed, the body position of the infant is bound through the fixing bandage, the infant is shaken if necessary, then the bell sound generated by the toy is matched to reduce the discomfort of the infant, the adjusting frame is adjusted to enable the milk bottle-shaped built-in tank to move to the front of the infant, the infant holds the milk bottle and places the nipple-shaped sampling head in the oral cavity for sucking, the rotation of the rotating module drives the sampling layer to synchronously and circumferentially rotate at the moment, so that the oral cavity mucous membrane is scraped and collected, the sampling device is taken out from the mouth of the infant after the collection, the oral cavity of the infant is cleaned, then the driving cylinder drives the sampling head, the rotating module and the sampling layer to integrally retract into the built-in tank, the rotating module rotates again to enable the sampling layer to circumferentially rotate, when the sampling layer rotates right below, sampling layer and the unblock of rotation module, thereby in dropping the collection frame, thereby collect the sample, will collect the frame and take out the back and pour into cell fixing liquid into, the sampling is accomplished, because the infant can produce the conflict psychology to the foreign matter of filling in the oral cavity, consequently earlier through infant's bed, the toy has reduced the uncomfortable sense of infant to the surrounding environment, the rethread feeding bottle, the sampling device of nipple shape makes the infant initiatively put into the mouth with sampling device (can fill in the infant's mouth by its father's mother is supplementary when not initiatively filling in the mouth), compare in compelling filling in, greatly reduced the sense of conflict, for the sampling efficiency has been improved, later evenly scrape the oral cavity mucous membrane liquid with the multiunit sampling layer through circumferential direction's mode, later unlock the whereabouts to these sampling layers again, thereby carry out the concentrated collection of sample.

Preferably, the cleaning module is installed to the upper end of built-in jar, the cleaning module includes air pump, power and switch, the storage chamber has been seted up to the upper end of built-in jar, the spraying hole has been seted up to the upper end of the inner chamber wall of built-in jar, the air pump is installed in the intercommunication between storage chamber and the spraying hole, installs for the electricity to be connected between air pump and power, the switch in the built-in jar, the on & off switch part of switch is towards the right-hand member of sampling head.

Preferably, the inside of sealed lid is provided with rotatable cleaning member, cleaning member is including rotating a section of thick bamboo, butt joint spare, it is connected for normal running fit to rotate between a section of thick bamboo and the sealed lid, the rotation handle is installed to the left end of rotating a section of thick bamboo, the inside joint that rotates a section of thick bamboo has butt joint spare, the inside laminating of butt joint spare has the layer of cleaning, butt joint spare is combined by the semicircle spare of two docks and is constituteed, and the structure between the inside of butt joint spare after combining agrees with mutually with of sampling head.

Through adopting above-mentioned technical scheme, when the sampling head withdrawed into built-in jar and lifted the unblock of sampling layer off (closing sealed lid after the sampling head withdrawal), the sampling head contacts the switch and opens the switch, the air pump circular telegram was spun in carrying the spray orifice with the cleaning solution in storing the chamber this moment, thereby to sampling head clean surface (before the cleaning solution is carried and is not spun, the sampling layer all unloads, and will collect the frame and move to the right and take out, therefore the cleaning solution can not contact with gathering the sample), later drive the sampling head left side through driving actuating cylinder and reset, at this moment, wipe layer and wipe layer surface contact, handheld rotation handle rotates and drives the rotor, the butt joint rotates, synchronous pivoted wipe the layer to the sampling head surface, it is clean to adopt the fog to spout, the dual mode of contact wiping reaches clear purpose, do benefit to subsequent reutilization.

Preferably, the opening position of collecting the frame is provided with the sealing layer, the sealing layer includes closing plate, rubber barrier block, the drawing groove has been seted up to the lower extreme of built-in jar, it slides and sets up in the drawing groove to collect the frame, it is provided with the closing plate to slide on the opening position of collecting the frame, the rubber barrier plate is installed to the right-hand member of closing plate, the rubber barrier plate cooperatees with the rubber barrier block of installing on drawing groove upper end right side, the feed liquor chamber has been seted up on the collection frame, inside the directional collection frame of exit position in feed liquor chamber, the entrance position in feed liquor chamber blocks up there is the sealing plug.

Through adopting above-mentioned technical scheme, drop in the collection frame after sampling layer and the unblock of rotation module, pull out the collection frame right after whole droppings, block the piece at rubber, the flexibility blocks down between the rubber barrier plate, the closing plate is closed the open position of collecting the frame, again because rubber blocks the piece, the rubber barrier plate is the rubber material, follow-up exerting the separation of can warping slightly between the two, thereby lose and block the effect, this moment, the collection frame after sealing takes out, later open the sealing plug, thereby it is full of to collect the frame inside to pour into cell stationary liquid from the feed liquor chamber, make cell stationary liquid fully infiltrate the sampling layer, its inside is in sealed environment when having guaranteed to collect the frame and taking out in the setting of sealing layer, the entering of external foreign matter has been reduced.

Preferably, the sample sampler for detecting the infant mucosal gene is characterized in that: the adjustable support comprises a telescopic rod, a clamping sleeve and a handle, the upper end of the telescopic rod is fixedly connected with the support, the lower end of the telescopic rod is connected with the clamping sleeve of an arc-shaped structure through a pin shaft, a built-in tank is installed inside the clamping sleeve in a clamping mode, and the handle held by an infant is installed on the outer side of the clamping sleeve.

Through adopting above-mentioned technical scheme, through the flexible of telescopic link, the removal of support and the rotation between telescopic link, the joint cover to remove infant with sampling device and with the front, later, infant initiatively grasps the handle and fills in the oral cavity with sampling device.

Preferably, the sampling head comprises a rubber block, a suction pipe, a built-in pipe, a suction head and a cleaning column, the ejection end of the driving cylinder is installed on the rubber block, the suction pipe is installed in the middle of the rubber block, one end, far away from the driving cylinder, of the suction pipe is in threaded fit connection with the built-in pipe, the suction head is sleeved outside the built-in pipe, and the cleaning column corresponding to the position of the suction pipe is installed on the right end face of the inner cavity of the built-in tank.

Preferably, the suction pipe is communicated with a through hole in the middle of the suction head, the suction head is of a cavity structure, and the cleaning column is sleeved with a detachable sponge sleeve.

By adopting the technical scheme, when the sampling head needs to be further sterilized at regular intervals, the built-in pipe and the thread of the suction pipe are unscrewed, and then the rubber block, the suction pipe, the built-in pipe and the suction head are separated for one-to-one sterilization.

Preferably, the rotation module includes the rotating ring, drives the piece, promotes piece, the electronic slider of annular, cover and establishes the piece, be connected for normal running fit between rotating ring and the inner tube, the drive piece is installed to the right-hand member of rotating ring, drive the piece and promote the piece and cooperate, promote the piece and set up at the electronic slider of annular, the electronic slider of annular is installed in the ring channel that the rubber block was seted up, the cover that installs the rubber material is established to the outside cover of rotating ring and is established the piece, constitute complete nipple structure between rubber block, cover and the suction head.

Preferably, the inner wall of the rotating ring is uniformly provided with rolling balls along the circumferential direction, and the balls are attached to the outer surface of the suction pipe.

Preferably, the sampling layer includes the interior inserts, scrapes adnexed layer, elasticity locking piece, extrusion piece, unblock subassembly and spring liftout piece, the cover is established the piece and is evenly seted up embedded chamber along its circumference, and the surface of embedding at the interior inserts of embedded chamber is concave-convex structural plane, and has laid on the convex structural plane and collect scraping adnexed layer of adhesive film liquid, the right-hand member of interior inserts is provided with the elasticity locking piece, elasticity locking piece joint is in the joint inslot of embedded chamber right-hand member, the joint inslot slides and is provided with the extrusion piece, slides with extrusion piece matched with unblock subassembly and sets up some sliding tray at the rubber piece lower extreme, the one end laminating that interior inserts is close to the straw is on spring liftout piece, and the spring liftout piece that sets up on embedded chamber keeps outside ejecting trend to the inserts all the time.

Preferably, be connected with reset spring between unblock subassembly and the sliding tray, the unblock subassembly is corresponding with the position that the built-in jar inner chamber right side supported between the piece, the initial condition of elasticity locking piece is the arc structure of squinting from inside to outside gradually to the right.

By adopting the technical scheme, the annular electric sliding block drives the pushing block to rotate, the driving block, the rotating ring and the sleeved device are driven to rotate after the pushing block is contacted with the driving block, so as to drive the sampling layer to synchronously rotate, the mucous membrane is scraped and attached to be collected by the scraping layer during rotation, after collection, the sampling head, the rotating module and the sampling layer are driven to integrally retract into the built-in tank by the driving air cylinder until the abutting part is contacted with the unlocking component and pushes the unlocking component to the left side, at the moment, the unlocking component pushes the pressing block to the left side, so as to push the elastic locking part to be separated and unlocked from the clamping groove, the corresponding embedded part (unlocked) is ejected out under the elasticity of the spring ejecting part and falls down to the collecting frame, when the locked scraping layer rotates to the right lower side along with the rotation of the sleeved device, the unlocking part can be unlocked and fall down, and the rotating module and the sampling layer are temporarily embedded and locked, carry out interim embedding locking when mucous membrane liquid sampling, guaranteed to scrape that to attach the layer and scrape when attaching the position skew not, not fall, after gathering, through the extrusion unblock for what sampled scrapes and attaches layer unblock whereabouts, whole process need not to contact with the external world, has guaranteed to scrape cleanliness factor and the integrity of attaching layer surface sample, avoids suffering the pollution.

In summary, the present application includes at least one of the following beneficial technical effects:

1. according to the sample sampler for detecting the infant mucosa genes, disclosed by the invention, for the conflict psychology of infants, the adaptation degree of the infants to a strange environment is improved by changing the surrounding collection environment (infant beds and toys capable of making small bell sounds), then the appearance of the sampling device is changed into a milk bottle shape, so that the conflict psychology of the sampling device is reduced, the sampling device can be easily plugged into the mouth for collection, when the infants suck the samples (the collection positions are determined), the samples are collected by rotating a plurality of groups of sampling layers, the error of detection data is reduced due to the improvement of the collection amount, and then the collected samples are subjected to whole-course sealed non-contact conveying, so that the condition that the sample amount is reduced or polluted is avoided;

2. according to the sample sampler for detecting the infant mucosal gene, the conflict psychology of an infant is reduced by changing the appearance of the sampling device, when the sampling head is sucked by the infant, the sampling layer is driven to rotate through the rotating module, so that oral mucosal liquid is collected, the collection amount of the mucosal liquid is further improved through the scraping layer on the convex structural surface and the concave structural groove, the sampling head retracts into the built-in tank after collection, the sealing cover is covered, then the sampling head which rotates in an annular mode is unlocked and extruded one by one in a mode of extrusion unlocking to enable the sampling head to fall into the collection frame, the sampling head is collected in a non-contact whole process and is in a relatively sealed environment, and the pollution of the outside to the sample is reduced;

3. according to the sample sampler for detecting the infant mucosal gene, the sampling head and the rotating module are cleaned by the cleaning module and the cleaning piece, so that secondary utilization is facilitated, and the condition that different samples are infected with each other is reduced;

4. according to the sample sampler for detecting the infant mucosal gene, the sealing layer is arranged to ensure that the opening position of the collecting frame is in sealed storage when the collecting frame is pulled out, so that the pollution of the outside to the sample is reduced.

Drawings

The invention is further illustrated with reference to the following figures and examples.

FIG. 1 is a schematic structural view of the present invention;

FIG. 2 is a schematic structural diagram of the adjusting frame and the sampling device (except for a resisting part and a driving cylinder);

FIG. 3 is a cross-sectional view of the sampling device, cleaning module, cleaning member and sealing layer of the present invention;

FIG. 4 is a schematic structural diagram of the present invention between the internal canister, sampling head, rotation module and sampling layer;

FIG. 5 is a cross-sectional view of the invention of FIG. 4;

FIG. 6 is a schematic structural view of the present invention between the rotating ring, the driving block, the pushing block and the annular electric slider;

fig. 7 is a schematic structural view between the rotary cylinder and the abutment member according to the present invention.

Description of reference numerals: 1. infant beds; 2. fixing a binding band; 3. a support; 4. an adjusting bracket; 41. a telescopic rod; 42. a clamping sleeve; 43. a handle; 5. a sampling device; 51. a built-in tank; 53. a driving cylinder; 54. a sampling head; 541. a rubber block; 542. a straw; 543. a build-in tube; 544. a suction head; 545. cleaning the column; 55. a rotation module; 551. a rotating ring; 552. driving the block; 553. a pushing block; 554. an annular electric slider; 555. sleeving a part; 56. a sampling layer; 561. an inner embedded piece; 562. scraping the adhesion layer; 563. a resilient locking member; 564. extruding the block; 565. an unlocking assembly; 566. a spring ejector; 567. a resisting part; 57. a collection frame; 58. a sealing cover; 6. a cleaning module; 61. an air pump; 62. a power source; 63. a switch; 7. a cleaning member; 71. a rotating cylinder; 72. a docking member; 8. a sealing layer; 81. a sealing plate; 82. a rubber barrier plate; 83. a rubber stopper.

Detailed Description

The present application is described in further detail below with reference to figures 1-7.

The embodiment of the application discloses to infant's mucosa gene detection sample thief, can reduce the infant and contradict simultaneously can be rapidly to the sampling in the oral cavity mucosa and to the sealed collection of sample, improve the practicality of actual sample thief greatly.

The first embodiment is as follows:

referring to fig. 1, a sample sampler for detecting infant mucosa genes disclosed in this embodiment includes an infant bed 1, a fixing band 2 is installed in the middle of the infant bed 1, a support 3 is slidably installed at the upper end of the infant bed 1, and toys capable of generating a bell sound are hung on the front and rear sides of the upper end of the support 3.

Referring to fig. 2-6, in order to quickly sample the oral mucosa while reducing the infant's conflict, an adjusting bracket 4 is installed at the middle of the upper end of the bracket 3 in this embodiment, the lower end of the adjusting frame 4 is provided with a sampling device 5, the sampling device 5 comprises a built-in tank 51, a driving cylinder 53, a sampling head 54, a rotating module 55, a sampling layer 56, a collecting frame 57 and a sealing cover 58, the middle part of the built-in tank 51 is connected with a slidable sampling head 54 through a driving cylinder 53, the built-in tank 51 is in the shape of a feeding bottle, the sampling head 54 is in the shape of a nipple, the middle part of the sampling head 54 is provided with a rotating module 55 in a rotating fit manner, the rotating module 55 is uniformly provided with sampling layers 56 along the circumferential direction, the sampling layers 56 are used for sampling oral mucosa, the lower end of the built-in tank 51 is provided with a collecting frame 57, and the sampling head 54 is sleeved with a sealing cover 58.

During actual sampling, an infant is placed in the infant bed 1, the body position of the infant is bound through the fixing bandage 2, the infant shakes when necessary, the bell sound generated by the toy is matched, the discomfort of the infant is reduced, then the adjusting frame 4 is adjusted to enable the milk bottle-shaped built-in tank 51 to move to the front of the infant, the infant holds the milk bottle-shaped built-in tank and places the nipple-shaped sampling head 54 into the oral cavity for sucking, the sampling layer 56 is driven to synchronously rotate circumferentially through rotation of the rotating module 55, so that the oral cavity mucous membrane is scraped and collected, the sampling device 5 is taken out of the mouth of the infant after collection, the oral cavity of the infant is cleaned, then the sampling head 54, the rotating module 55 and the sampling layer 56 are driven to integrally retract into the built-in tank 51 through the driving cylinder 53, the rotating module 55 rotates again to enable the sampling layer 56 to rotate circumferentially, when the sampling layer 56 is rotated right down, the sampling layer 56 is unlocked from the rotation module 55, thereby falling into the collection frame 57, so as to collect the sample, the collection frame 57 is taken out and injected with the cell fixing liquid, the sampling is completed, because the infant can produce conflict psychology to the foreign matter of filling in the oral cavity, consequently earlier through infant's bed 1, the toy has reduced the uncomfortable sense of infant to the surrounding environment, the rethread feeding bottle, the sampling device 5 of nipple shape makes the infant initiatively put into the mouth with sampling device 5 (can fill in the infant's mouth by its father's mother is supplementary when not initiatively filling in the mouth), compare in compelling filling in, greatly reduced conflict sense, for the sampling efficiency has been improved, later evenly scrape the oral cavity mucus membrane with multiunit sampling layer 56 through circumferential direction's mode, later unlock these sampling layers 56 whereabouts again, thereby carry out the concentrated collection of sample.

Besides, in order to facilitate the sampling device 5 to reach a proper position, the adjusting frame 4 comprises an expansion link 41, a clamping sleeve 42 and a handle 43, the upper end of the expansion link 41 is fixedly connected with the bracket 3, the lower end of the expansion link 41 is connected with the clamping sleeve 42 with an arc structure through a pin shaft, an internal tank 51 is clamped and installed inside the clamping sleeve 42, the handle 43 held by an infant is installed on the outer side of the clamping sleeve 42, the sampling device 5 is moved to the front of the infant through expansion and contraction of the expansion link 41, movement of the bracket 3 and rotation between the expansion link 41 and the clamping sleeve 42, and then the infant actively grasps the handle 43 and plugs the sampling device 5 into the oral cavity.

Referring to fig. 4-5, the sampling head 54 includes a rubber block 541, a suction pipe 542, an internal tube 543, a suction head 544 and a cleaning column 545, the ejection end of the driving cylinder 53 is mounted on the rubber block 541, the suction pipe 542 is mounted in the middle of the rubber block 541, one end of the suction pipe 542 far from the driving cylinder 53 is in threaded fit connection with the internal tube 543, the suction head 544 is sleeved outside the internal tube 543, the cleaning column 545 corresponding to the suction pipe 542 is mounted on the right end face of the inner cavity of the internal tank 51, the suction pipe 542 is communicated with a through hole in the middle of the suction head 544, the interior of the suction head 544 is in a cavity structure, a detachable sponge sleeve is sleeved outside the cleaning column 545, and a part of saliva can enter the suction pipe 542 and the internal tube 543 when an infant sucks, and after the sampling head 54 retracts into the internal tank 51, the cleaning column 545 and the sponge sleeve can enter the suction pipe 542, The tube 543 is provided to absorb the liquid therein.

When the sampling head 54 needs to be sterilized further regularly, the built-in tube 543 and the pipette 542 are unscrewed, and then the rubber block 541, the pipette 542, the built-in tube 543, and the pipette tip 544 are separated to be sterilized one by one.

Referring to fig. 2-6, in order to further ensure the increase of the collection amount, the rotating module 55 includes a rotating ring 551, a driving block 552, a pushing block 553, an annular electric slider 554, and a sleeve member 555, the rotating ring 551 and the inner tube 543 are connected in a rotating fit manner, the driving block 552 is installed at the right end of the rotating ring 551, the driving block 552 is matched with the pushing block 553, the pushing block 553 is arranged on the annular electric slider 554, the annular electric slider 554 is installed in an annular groove formed in the rubber block 541, the sleeve member 555 made of rubber material is sleeved outside the rotating ring 551, the rubber block 541, the sleeve member 555 and the suction head 544 form a complete nipple structure, the nipple structure design reduces the interference psychology of the infant, the inner wall of the rotating ring 551 is uniformly provided with rolling balls along the circumferential direction thereof, and the balls are attached to the outer surface of the suction tube 542, the frictional resistance when the rotating ring 551 rotates is reduced.

Referring to fig. 2-5, the sampling layer 56 includes an inner insert 561, an attaching scraping layer 562, an elastic locking member 563, a squeezing block 564, an unlocking member 565 and a spring ejecting member 566, the sleeve 555 has an embedded cavity along its circumference, the outer surface of the inner insert 561 embedded in the embedded cavity is a concave-convex structure surface, the design of the concave-convex structure surface ensures that a part of the mucus can be scraped into the concave structure while the scraping layer 562 scrapes the mucus, thereby increasing the collection amount, the scraping layer 562 for collecting the mucus is laid on the convex structure surface, the right end of the inner insert 561 is provided with the elastic locking member 563, the elastic locking member 563 is clamped in a clamping groove at the right end of the embedded cavity and is in a temporary locking state, the squeezing block 564 is slidably arranged in the clamping groove, the unlocking member 565 matched with the squeezing block 564 is slidably arranged in a sliding groove formed at the lower end of the rubber block 541, one end of the inner insert 561, which is close to the suction pipe 542, is attached to the spring ejecting piece 566, the spring ejecting piece 566 arranged on the inner embedded cavity always keeps the tendency of ejecting the inner insert 561 outwards, after the inner insert 561 is unlocked, the spring ejecting piece 566 can directly push the inner insert 561 out in an elastic manner, so that the inner insert 561 is guaranteed to be smoothly pushed out from the inner embedded cavity, the scraping layer 562 is made of flocking materials, the inner insert 561 and the elastic locking piece 563 are both made of ABS plastic materials and are non-toxic materials used in sample collection for medical use, a return spring is connected between the unlocking assembly 565 and the sliding groove, the unlocking assembly 565 corresponds to the position between the abutting piece 567 on the right side of the inner cavity of the inner tank 51, the initial state of the elastic locking piece 563 is an arc structure gradually deviated from inside to outside to the right, the elastic locking piece 563 is clamped in the clamping groove in a natural state due to the arrangement of the arc structure, when the extrusion piece 564 extrudees the elastic locking piece 563, the elastic locking piece 563 is in a vertical state, and the elastic locking piece 563 is separated from the clamping groove at the moment, so that the unlocking purpose is achieved.

When the rotating module 55 is matched with the sampling layer 56 for sampling, the annular electric slide block 554 drives the pushing block 553 to rotate, the pushing block 553 is contacted with the driving block 552 and then drives the driving block 552, the rotating ring 551 and the sleeving piece 555 to rotate so as to drive the sampling layer 56 to synchronously rotate, mucous membrane is scraped and collected through the scraping layer 562 during rotation, after collection, the sampling head 54, the rotating module 55 and the sampling layer 56 are integrally retracted into the built-in tank 51 through the driving cylinder 53 until the propping piece 567 is contacted with the unlocking piece 565 and pushed to the left side, at the moment, the unlocking piece 565 pushes the pressing block 564 to the left side so as to push the elastic locking piece 563 to the left side, the propped elastic locking piece 563 is separated and unlocked from the clamping groove, the corresponding internal insert 561 (unlocked) is pushed out under the elasticity of the spring propping piece 566 and then falls to the collection frame 57 along with the rotation of the sleeving piece 555, whenever the locking scrape when attaching layer 562 and rotate to under, all can the unblock whereabouts, rotate and lock for interim embedding between module 55 and the sampling layer 56, carry out interim embedding locking when mucous membrane liquid sampling, guaranteed to scrape that the position does not squint when attaching layer 562 scrapes, do not fall, after gathering, through the extrusion unblock, make what sampled scrape and attach layer 562 unblock whereabouts, whole process need not to contact with the external world, guaranteed to scrape the cleanliness factor and the integrity of attaching layer 562 surface sample, avoid suffering the pollution.

Example two:

referring to fig. 3, on the basis of the first embodiment, in order to clean the sampler after sampling, in the second embodiment, the cleaning module 6 is installed at the upper end of the built-in tank 51, the cleaning module 6 includes an air pump 61, a power source 62 and a switch 63, a storage cavity is opened at the upper end of the built-in tank 51 and is used for storing cleaning liquid, a spraying hole is opened at the upper end of the inner cavity wall of the built-in tank 51, the air pump 61 is installed between the storage cavity and the spraying hole in a communicating manner, the air pump 61 installed in the built-in tank 51 is electrically connected with the power source 62 and the switch 63, and the switch key part of the switch 63 faces the right end of the sampling head 54, so that the sampling head 54 can contact the switch 63 and be turned on when moving to a certain position right.

Referring to fig. 3 and 7, a rotatable cleaning piece 7 is arranged inside the sealing cover 58, the cleaning piece 7 includes a rotating cylinder 71 and a butt joint piece 72, the rotating cylinder 71 and the sealing cover 58 are connected in a rotating fit manner, a rotating handle is installed at the left end of the rotating cylinder 71, the butt joint piece 72 is connected to the inside of the rotating cylinder 71 in a clamped manner, a wiping layer is attached to the inside of the butt joint piece 72, the butt joint piece 72 is formed by combining two butted semicircular pieces, the butt joint piece 72 and the rotating cylinder 71 are detachable, the butt joint piece 72 is detachable, subsequent normal replacement of the wiping layer is guaranteed, and the combined inside of the butt joint piece 72 is matched with a structure between the sampling head 54.

Through the dual mode of mist spraying and hijack type wiping, when the sampling head 54 retracts into the built-in tank 51 and unlocks the sampling layer 56 (the sealing cover 58 is closed after the sampling head 54 retracts), the sampling head 54 contacts the switch 63 and opens the switch 63, the air pump 61 is electrified to convey the cleaning liquid in the storage cavity to the spray holes to be sprayed out, so that the surface of the sampling head 54 is cleaned (before the cleaning liquid is conveyed and is not sprayed out, the sampling layer 56 is unlocked and unloaded, and the collection frame 57 is moved to the right and is taken out, so that the cleaning liquid cannot be contacted with a collected sample), then the left side of the sampling head 54 is driven to reset through the driving air cylinder 53, at the moment, the wiping layer is contacted with the surface of the wiping layer, the rotating cylinder 71 and the butting piece 72 are driven to rotate by rotating the handheld rotating handle, the synchronously rotating wiping layer wipes the surface of the sampling head 54, and the dual mode of mist spraying cleaning and contact wiping is adopted to achieve the cleaning purpose, is beneficial to subsequent secondary utilization.

Example three:

referring to fig. 3, on the basis of the second embodiment, in order to ensure that the opening position of the collection frame is sealed when the collection frame is taken out, in the third embodiment, the opening position of the collection frame 57 is provided with the sealing layer 8, the sealing layer 8 includes a sealing plate 81, a rubber blocking plate 82 and a rubber blocking block 83, the lower end of the built-in tank 51 is provided with a drawing groove, the collection frame 57 is slidably arranged in the drawing groove, the opening position of the collection frame 57 is slidably provided with the sealing plate 81, the right end of the sealing plate 81 is provided with the rubber blocking plate 82, the rubber blocking plate 82 is matched with the rubber blocking block 83 arranged on the right side of the upper end of the drawing groove, the rubber blocking plate 82 and the rubber blocking 83 block mutually block during initial contact, but with the increase of the force, the characteristics of rubber deformation of the two are reflected, when the force is increased to a certain degree, the liquid inlet cavity and the liquid outlet cavity are separated after being deformed, the collecting frame 57 is provided with the liquid inlet cavity, the outlet position of the liquid inlet cavity points to the inside of the collecting frame 57, the inlet position of the liquid inlet cavity is blocked by a sealing plug, and the inlet position of the liquid inlet cavity is sealed or opened by the sealing plug.

Drop in collection frame 57 after sampling layer 56 and rotation module 55 unblock, pull out collection frame 57 right after all fall, block 83 at the rubber, under the flexible blocking between rubber barrier 82, closing plate 81 closes the open position of collecting frame 57, again because rubber blocks 83, rubber barrier 82 is the rubber material, follow-up exert power slightly and say between the two can the deformation separation, thereby lose and block the effect, at this moment, the collection frame 57 after sealing takes out, later open the sealing plug, thereby it is full of to collect frame 57 inside to pour into cell stationary liquid from the feed liquor chamber into, make cell stationary liquid fully infiltrate sampling layer 56, inside when having guaranteed collection frame 57 to take out of sealing layer 8 is in sealed environment, the entering of external foreign matter has been reduced.

The implementation principle of the embodiment is as follows:

s1, putting the infant into the infant bed 1, binding the infant body through the fixing bandage 2, moving the milk bottle-shaped built-in tank 51 to the front of the infant, and inserting the milk bottle-shaped built-in tank into the oral cavity;

s2, the rotation of the rotating module 55 drives the sampling layer 56 to rotate circumferentially, so that the oral mucosa liquid is scraped and collected;

s3, taking out the sampling device 5 from the mouth of the infant after collection, carrying the infant away from the infant bed 1, and cleaning the oral cavity of the infant;

s4, the sampling head 54, the rotating module 55 and the sampling layer 56 are driven to integrally retract into the built-in tank 51 by driving the air cylinder 53, the sealing cover 58 is covered, the abutting piece 567 is in contact with the unlocking component 565 and pushes the unlocking component 565 to the left side, the switch 63 is opened (the cleaning liquid is conveyed after the air pump 61 is electrified), the sampling layer 56 moves circumferentially along with the rotation of the rotating module 55, and when one sampling layer 56 rotates to the right lower side, the sampling layer 56 is extruded from the built-in cavity to fall into the collecting frame 57 for collection, and after the collecting frame 57 is pulled out to the right, the cleaning liquid conveyed at high pressure is sprayed out from the spraying holes, so that the sampling head 54 is cleaned;

s5 the collection frame 57 is sealed and stored when being pulled out completely, and at the moment, cell fixing liquid is injected into the collection frame;

s6, after the sampling head 54 is sprayed for a period of time, the sampling head 54 is driven to move leftwards and reset by the driving air cylinder 53, and at the moment, the surface of the sampling head 54 is wiped by the cleaning piece 7;

and S7, keeping the current sealing state when not used, opening the sealing cover 58 when needing to be used again, and buckling a new sampling layer 56 again for the next round of collection.

While certain exemplary embodiments of the present invention have been described above by way of illustration only, it will be apparent to those of ordinary skill in the art that the described embodiments may be modified in various different ways without departing from the spirit and scope of the invention. Accordingly, the drawings and description are illustrative in nature and should not be construed as limiting the scope of the invention.

Claims (10)

1. The utility model provides a to infant's mucosa gene detection sample thief, includes infant's bed (1), the mid-mounting of infant's bed (1) has fixing bandage (2), the upper end of infant's bed (1) slides and is provided with support (3), both sides hang around the upper end of support (3) and have the toy that can send out small bell sound, its characterized in that: the middle part of the upper end of the support (3) is provided with an adjusting frame (4), the lower end of the adjusting frame (4) is provided with a sampling device (5), the sampling device (5) comprises a built-in tank (51), a driving cylinder (53), a sampling head (54), a rotating module (55), a sampling layer (56), a collecting frame (57) and a sealing cover (58), the middle part of the built-in tank (51) is connected with the slidable sampling head (54) through the driving cylinder (53), the built-in tank (51) is in a milk bottle shape, the sampling head (54) is in a nipple shape, the rotating module (55) is arranged in the middle part of the sampling head (54) in a rotating matching manner, the sampling layer (56) is uniformly arranged on the rotating module (55) along the circumferential direction of the rotating module, the sampling layer (56) is used for sampling oral mucosa, the collecting frame (57) is arranged at the lower end of the built-in tank (51), the sampling head (54) is sleeved with a sealing cover (58).

2. The sample sampler for detecting infant mucosal genes according to claim 1, wherein: the cleaning device is characterized in that a cleaning module (6) is mounted at the upper end of the built-in tank (51), the cleaning module (6) comprises an air pump (61), a power supply (62) and a switch (63), a storage cavity is formed in the upper end of the built-in tank (51), a spraying hole is formed in the upper end of the inner cavity wall of the built-in tank (51), the air pump (61) is mounted between the storage cavity and the spraying hole in a communicating mode, the air pump (61) mounted in the built-in tank (51) is electrically connected with the power supply (62) and the switch (63), and the switch key part of the switch (63) faces the right end of the sampling head (54); the inside of sealed lid (58) is provided with rotatable cleaning member (7), cleaning member (7) are including rotating a section of thick bamboo (71), butt joint spare (72), it is connected for normal running fit between a section of thick bamboo (71) and sealed lid (58) to rotate, the rotation handle is installed to the left end of rotating a section of thick bamboo (71), the inside joint of rotating a section of thick bamboo (71) has butt joint spare (72), the inside laminating of butt joint spare (72) has the layer of wiping, butt joint spare (72) are merged by the semicircle piece of two docks and are constituteed, and the structure between the inside of butt joint spare (72) after merging agrees with mutually with sampling head (54).

3. The sample sampler for detecting infant mucosal genes according to claim 1, wherein: the opening position of collecting frame (57) is provided with sealing layer (8), sealing layer (8) are including closing plate (81), rubber barrier plate (82), rubber stop block (83), the drawing groove has been seted up to the lower extreme of built-in jar (51), it slides and sets up in the drawing groove to collect frame (57), it is provided with closing plate (81) to slide on the opening position of collecting frame (57), rubber barrier plate (82) are installed to the right-hand member of closing plate (81), rubber barrier plate (82) block piece (83) with the rubber of installing on drawing groove upper end right side and cooperate, the feed liquor chamber has been seted up on collecting frame (57), inside directional collection frame (57) in the exit position in feed liquor chamber, the import position in feed liquor chamber blocks up there is the sealing plug.

4. The sample sampler for detecting infant mucosal genes according to claim 1, wherein: the adjustable support (4) comprises an expansion rod (41), a clamping sleeve (42) and a handle (43), the upper end of the expansion rod (41) is fixedly connected with the support (3), the lower end of the expansion rod (41) is connected with the clamping sleeve (42) of an arc-shaped structure through a pin shaft, a built-in tank (51) is installed in the clamping sleeve (42) in a clamped mode, and the handle (43) held by an infant is installed on the outer side of the clamping sleeve (42).

5. The sample sampler for detecting infant mucosal genes according to claim 1, wherein: the sampling head (54) comprises a rubber block (541), a suction pipe (542), a built-in pipe (543), a suction head (544) and a cleaning column (545), wherein the ejection end of the driving cylinder (53) is installed on the rubber block (541), the suction pipe (542) is installed in the middle of the rubber block (541), one end, far away from the driving cylinder (53), of the suction pipe (542 is connected with the built-in pipe (543) in a threaded fit mode, the suction head (544) is sleeved outside the built-in pipe (543), and the cleaning column (545) corresponding to the position of the suction pipe (542) is installed on the right end face of an inner cavity of the built-in tank (51).

6. The sample sampler for detecting infant mucosal genes according to claim 5, wherein: the suction pipe (542) is communicated with a through hole in the middle of the suction head (544), the suction head (544) is internally of a cavity structure, and a detachable sponge sleeve is sleeved outside the cleaning column (545).

7. The sample sampler for detecting infant mucosal genes according to claim 5, wherein: the rotating module (55) comprises a rotating ring (551), a driving block (552), a pushing block (553), an annular electric slider (554) and a sleeving piece (555), the rotating ring (551) is connected with the built-in pipe (543) in a rotating fit mode, the driving block (552) is installed at the right end of the rotating ring (551), the driving block (552) is matched with the pushing block (553), the pushing block (553) is arranged on the annular electric slider (554), the annular electric slider (541) is installed in an annular groove formed in the rubber block (541), the sleeving piece (555) made of rubber materials is installed on the outer portion of the rotating ring (551), and a complete nipple structure is formed between the rubber block (541), the sleeving piece (555) and the suction head (544).

8. The sample sampler for detecting infant mucosal genes according to claim 7, wherein: the inner wall of the rotating ring (551) is uniformly provided with rolling balls along the circumferential direction, and the balls are attached to the outer surface of the suction pipe (542).

9. The sample sampler for detecting infant mucosal genes according to claim 7, wherein: the sampling layer (56) comprises an inner insert (561), a scraping layer (562), an elastic locking piece (563), an extruding block (564), an unlocking assembly (565) and a spring ejecting piece (566), wherein the sleeve (555) is uniformly provided with an embedded cavity along the circumferential direction of the sleeve, the outer surface of the inner insert (561) embedded in the embedded cavity is a concave-convex structural surface, the scraping layer (562) for collecting a viscose solution is paved on the convex structural surface, the right end of the inner insert (561) is provided with the elastic locking piece (563), the elastic locking piece (563) is clamped in a clamping groove at the right end of the embedded cavity, the extruding block (564) is arranged in the clamping groove in a sliding manner, the unlocking assembly (565) matched with the extruding block (564) is arranged in a sliding groove formed in the lower end of the rubber block (541) in a sliding manner, one end of the inner insert (561), close to the suction pipe (542), is attached to the spring ejecting piece (566), a spring ejector (566) disposed on the insert cavity always maintains a tendency to eject the inner insert (561) outward.

10. The sample sampler for detecting infant mucosal genes according to claim 9, wherein: a return spring is connected between the unlocking component (565) and the sliding groove, the unlocking component (565) corresponds to the position between the abutting pieces (567) on the right side of the inner cavity of the built-in tank (51), and the initial state of the elastic locking piece (563) is an arc structure which gradually deviates to the right from inside to outside.

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