CN114733406A - Shake even device and have this fluorescence immunoassay appearance that shakes even device - Google Patents

Shake even device and have this fluorescence immunoassay appearance that shakes even device Download PDF

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Publication number
CN114733406A
CN114733406A CN202210335175.2A CN202210335175A CN114733406A CN 114733406 A CN114733406 A CN 114733406A CN 202210335175 A CN202210335175 A CN 202210335175A CN 114733406 A CN114733406 A CN 114733406A
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Prior art keywords
driving
pull rod
fixed shaft
shake
drive
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CN202210335175.2A
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Chinese (zh)
Inventor
谢晓东
王颖
郭绪智
唐浩
袁凯
席再军
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Wuhan Easydiagnosis Biomedicine Co ltd
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Wuhan Easydiagnosis Biomedicine Co ltd
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Priority to CN202210335175.2A priority Critical patent/CN114733406A/en
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5302Apparatus specially adapted for immunological test procedures
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531Production of immunochemical test materials
    • G01N33/532Production of labelled immunochemicals
    • G01N33/533Production of labelled immunochemicals with fluorescent label

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  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
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  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
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  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

The invention relates to a shaking-up device and a fluorescence immunoassay analyzer with the shaking-up device, wherein the shaking-up device comprises a driving mechanism and a gripper mechanism, and the driving mechanism comprises a fixed shaft, a pull rod, a first driving component and a second driving component; the end part of the fixed shaft is provided with a through hole, the pull rod is arranged in the through hole in a sliding manner, the output end of the first driving assembly is connected with one end of the pull rod so as to drive the pull rod to slide in the sliding stroke of the pull rod, and the other end of the pull rod is connected with the gripper mechanism so as to drive the gripper mechanism to open or close in the sliding process; the second driving assembly is connected with one end of the fixed shaft, and the other end of the fixed shaft is fixedly connected with the gripper mechanism so as to drive the gripper mechanism to swing in a reciprocating manner. Compared with the prior art, the shaking device provided by the invention has the beneficial effects that: on one hand, the worker can shake the test tube uniformly through the gripper mechanism and the driving mechanism, so that more labor is saved; on the other hand, the structure of the driving mechanism in the device is compact.

Description

Shake even device and have this fluorescence immunoassay appearance that shakes even device
Technical Field
The invention relates to the technical field of medical instrument detection, in particular to a shaking device and a fluorescence immunoassay analyzer with the same.
Background
Because the blood sample can generate component sinking and segregation phenomenon after being placed for a long time, and the component sinking and segregation phenomenon in the blood sample can cause the sample concentration of the blood sample to be not in accordance with the actual situation, the result of detection and analysis is influenced, and misleading is brought to the diagnosis of doctors.
Therefore, before performing the blood sample test, the worker usually shakes the blood sample manually and puts it into a testing device (such as a fluorescence immunoassay analyzer) for testing, which has the following disadvantages: shake even mode through the manual work, not only efficiency is lower, still can increase staff's work burden.
Therefore, a shaking device is needed to solve the problem that the workload of the staff is increased in the existing medical detection equipment.
Disclosure of Invention
In view of the above, it is necessary to provide a shaking device and a fluorescence immunoassay analyzer having the same, so as to solve the problem that the workload of the worker is increased in the conventional medical detection equipment.
The invention provides a shaking device which comprises a driving mechanism and a gripper mechanism, wherein the driving mechanism comprises a fixed shaft, a pull rod, a first driving assembly and a second driving assembly;
the end part of the fixed shaft is provided with a through hole in the axial direction, the pull rod is arranged in the through hole in a sliding manner, the output end of the first driving assembly is connected with one end of the pull rod so as to drive the pull rod to slide in the sliding stroke of the pull rod, and the other end of the pull rod is connected with the driving end of the gripper mechanism so as to drive the gripper mechanism to open or close in the sliding process;
the output end of the second driving component is connected with one end of the fixed shaft, and the other end of the fixed shaft is fixedly connected with the fixed end of the gripper mechanism to drive the gripper mechanism to swing back and forth in the swing stroke of the gripper mechanism.
Furthermore, the first driving assembly comprises a first driving piece and a connecting piece, the output end of the first driving piece is fixedly connected with one end of the connecting piece, and the other end of the connecting piece is rotatably connected with one end of the pull rod so as to drive the pull rod to slide relative to the fixed shaft.
Furthermore, the second driving assembly comprises a second driving piece, a transmission assembly and a control module, the output end of the second driving piece is connected with the fixed shaft through the transmission assembly, and the control module is electrically connected with the second driving piece so as to drive the gripper mechanism to swing around the fixed shaft in a reciprocating manner through the second driving piece.
Further, shake even device and still include the response part, the response part fixed set up in one side of gripper mechanism to when not being provided with the test tube lid on the test tube that gripper mechanism held, produce the sensing signal.
Further, the gripper mechanism comprises a mounting seat, a first sliding block and two groups of gripper assemblies, each gripper assembly comprises a second sliding block and a gripper, and the second sliding blocks are fixedly connected with the grippers;
one side of the mounting seat is fixedly connected with one end of the fixed shaft, the other side of the mounting seat is connected with the two second sliding blocks in a sliding mode, two sides of the first sliding block are connected with the two second sliding blocks in a sliding mode respectively, and the pull rod penetrates through the mounting seat and is fixedly connected with the first sliding block so as to drive the two second sliding blocks to be away from or close to each other.
Furthermore, two second sliders are respectively formed with oblique spout in relative one side, the both sides of first slider are respectively formed with the bellying, first slider set up in two between the second slider, and two the bellying slides respectively and sets up in two in the oblique spout.
Furthermore, the tongs subassembly still includes the cushion, the cushion fixed set up in be used for grabbing the position of test tube in the tongs.
Further, shake even device and still include first mounting panel, second mounting panel and third drive assembly, the fixed axle rotate set up in on the first mounting panel, first drive assembly and second drive assembly all fixed set up in on the first mounting panel, first mounting panel slide set up in on the second mounting panel, third drive assembly's output with first mounting panel is connected, in order to drive first mounting panel carries out elevating movement.
Further, the test tube shakes even device and still includes the slide rail, first mounting panel passes through the slide rail slide set up in on the second mounting panel.
On the other hand, the invention also provides a fluorescence immunoassay analyzer with the shaking device, which comprises the shaking device.
Compared with the prior art, the shaking device provided by the invention has the following beneficial effects:
1. the shaking-up device is provided with the gripper mechanism and the driving mechanism, when the test tube needs to be shaken up, a worker only needs to use the gripper mechanism and the driving mechanism in a matching manner, so that the shaking-up work of the test tube can be completed, and compared with a manual shaking-up mode in the prior art, the automatic degree of the mode is higher, and the labor is saved;
2. the driving mechanism consisting of the fixed shaft, the pull rod, the first driving assembly and the second driving assembly in the shaking device has a compact structure and occupies a small space.
Drawings
FIG. 1 is a schematic structural diagram of a shake-up apparatus according to a preferred embodiment of the present invention;
fig. 2 is a schematic structural diagram of a preferred embodiment of the first mounting plate, the gripper mechanism and the driving mechanism in the shaking device provided by the invention;
FIG. 3 is a cross-sectional view of FIG. 2;
FIG. 4 is a schematic structural view of the gripper mechanism and the driving mechanism of the shaking device provided by the present invention, except for the second driving assembly;
fig. 5 is a schematic structural view of the first mounting plate, the gripper mechanism and the driving mechanism of the shaking device provided by the present invention, except for the first driving assembly;
fig. 6 is a schematic structural view of a preferred embodiment of the fixed shaft, the pull rod and the gripping mechanism in the shaking device provided by the invention.
In the figure: 1. a drive mechanism; 11. a fixed shaft; 12. a pull rod; 13. a first drive assembly; 131. a first driving member; 132. a connecting member; 14. a second drive assembly; 141. a second driving member; 142. a transmission assembly; 2. a gripper mechanism; 21. a mounting seat; 22. a first slider; 221. a boss portion; 23. a gripper assembly; 231. a second slider; 231a, an inclined chute; 232. a gripper; 233. an elastic pad; 3. an inductive component; 4. a first mounting plate; 5. a second mounting plate; 6. a third drive assembly; 7. a slide rail.
Detailed Description
The accompanying drawings, which are incorporated in and constitute a part of this application, illustrate preferred embodiments of the invention and together with the description, serve to explain the principles of the invention and not to limit the scope of the invention.
Referring to fig. 1 to 5, the present invention provides a shaking-up device, which includes a driving mechanism 1 and a gripper mechanism 2, wherein the driving mechanism 1 is used for driving the gripper mechanism 2 to grip a test tube and swing the test tube to shake up a sample in the test tube.
The driving mechanism 1 comprises a fixed shaft 11, a pull rod 12, a first driving assembly 13 and a second driving assembly 14. The test tube testing device is characterized in that a through hole is formed in the end portion of the fixed shaft 11 in the axial direction, the pull rod 12 is arranged in the through hole in a sliding mode, the output end of the first driving assembly 13 is connected with one end of the pull rod 12 to drive the pull rod 12 to slide in the sliding stroke, the other end of the pull rod 12 is connected with the driving end of the gripper mechanism 2 to drive the gripper mechanism to open or close in the sliding process, specifically, when the gripper mechanism 2 clamps a test tube and correspondingly moves or shakes the test tube evenly, the gripper mechanism 2 is in a closed state, and when the gripper mechanism 2 finishes actions such as shaking the test tube evenly and needs to put the test tube back to the test tube rack, the gripper mechanism 2 is in an open state.
In the present embodiment, the gripper mechanism 2 is any clamping device that can be driven by the driving mechanism 1 in the prior art, and the present invention is not limited thereto.
The output end of the second driving assembly 14 is connected with one end of the fixed shaft 11, and the other end of the fixed shaft 11 is fixedly connected with the fixed end of the gripper mechanism 2, so as to drive the gripper mechanism 2 to swing back and forth around the fixed shaft 11, and further shake the test tubes clamped by the gripper mechanism 2 uniformly. It can be understood that the reciprocating swing range of the gripper mechanism 2 is controlled within a preset angle to ensure that the test tube completes the shaking motion, and if the preset angle is set to be not more than 120 degrees in the embodiment, the preset angle can be set by itself according to actual needs.
When the test tubes need to be shaken uniformly, the first driving component 13 can drive the gripper mechanism 2 to open, after the test tubes are placed in the clamping area of the gripper mechanism 2, the first driving component 13 can drive the gripper mechanism 2 to close (namely, clamping work of the test tubes is completed), and then the second driving component 14 can drive the gripper mechanism 2 to swing back and forth, so that shaking-up work of the test tubes is completed.
It should be noted that the shaking device may be used alone, or may be disposed in a medical detection device to be used in combination with other devices, which is not limited in the present invention.
Compared with the prior art, the shaking device provided by the invention has the following beneficial effects:
on one hand, the hand grab mechanism 2 and the driving mechanism 1 are arranged in the shaking-up device, when the test tube needs to be shaken up, a worker can complete the shaking-up work of the test tube only by using the hand grab mechanism 2 and the driving mechanism 1 in a matching manner, and compared with the mode of shaking up the test tube manually in the prior art, the mode has higher automation degree and is more labor-saving;
on the other hand, the driving mechanism 1 composed of the fixed shaft 11, the pull rod 12, the first driving component 13 and the second driving component 14 in the shaking device has a compact structure and occupies a small space.
Referring to fig. 2 to 4, as a preferred embodiment, the first driving assembly 13 includes a first driving member 131 and a connecting member 132, wherein the first driving member 131 is a linear motor, but in other embodiments, the first driving member 131 may also be other linear driving members, such as an air cylinder, a hydraulic cylinder, and the like, which is not limited in the present invention.
The output end of the first driving element 131 is fixedly connected to one end of the connecting element 132, and the other end of the connecting element 132 is rotatably connected to one end of the pull rod 12, so as to drive the pull rod 12 to slide relative to the fixed shaft 11, and further to slide in a sliding stroke.
Referring to fig. 5, as a preferred embodiment, the second driving assembly 14 includes a second driving member 141, a transmission assembly 142 and a control module (not shown in the drawings), wherein the second driving member 141 is a motor, the transmission assembly 142 is a synchronous belt assembly, but in other embodiments, the second driving member 141 may also be another rotary driving device, and the transmission assembly 142 may also be another transmission mechanism, such as a chain wheel, a gear set, etc., which is not limited in the present invention.
The output end of the second driving element 141 is connected to the fixed shaft 11 through the transmission assembly 142, and the control module is electrically connected to the second driving element 141 to drive the gripper mechanism 2 to swing back and forth within a preset swing angle range through the second driving element 141.
It should be noted that, in this embodiment, the control module may be any device capable of implementing the above control in the prior art, such as a PLC module, an industrial personal computer, and the like, which is not limited in this respect.
Referring to fig. 1 and 5, as a preferred embodiment, the shaking-up device further includes a sensing component 3, the sensing component 3 is fixedly disposed on one side of the gripper mechanism 2, so as to generate a sensing signal when no test tube cover is disposed on a test tube held by the gripper mechanism 2, so that a worker can automatically control the action of the second driving component 141 through a control device such as an industrial personal computer, and control the second driving component 141 not to act after the sensing component 3 generates the sensing signal.
Referring to fig. 6, as a preferred embodiment, the gripper mechanism 2 includes a mounting seat 21, a first sliding block 22, and two sets of gripper assemblies 23, the gripper assemblies 23 include a second sliding block 231 and a gripper 232, and the second sliding block 231 is fixedly connected to the gripper 232. One side of the mounting base 21 is fixedly connected with one end of the fixed shaft 11, the other side of the mounting base 21 is slidably connected with the two second sliding blocks 231, two sides of the first sliding block 22 are respectively slidably connected with the two second sliding blocks 231, and the pull rod 12 penetrates through the mounting base 21 and is fixedly connected with the first sliding block 22 so as to drive the two second sliding blocks 231 to be away from each other (at this time, the two grippers 232 are opened) or to be close to each other (at this time, the two grippers 232 are closed).
Referring to fig. 6, in a more specific embodiment, two oblique sliding grooves 231a are respectively formed on opposite sides of the two second sliders 231, two strip-shaped protruding portions 221 are respectively formed on two sides of the first slider 22, a distance between the two strip-shaped protruding portions 221 is sequentially reduced along a length direction of the first slider 22, the first slider 22 is disposed between the two second sliders 231, and the two strip-shaped protruding portions 221 are respectively slidably disposed in the two oblique sliding grooves 231 a.
Referring to fig. 6, as a preferred embodiment, the grip assembly 23 further includes an elastic pad 233, wherein the elastic pad 233 is a silicone sheet, but in other embodiments, the elastic pad 233 may also be another component, such as a rubber pad, which is not limited in the present invention. The elastic pad 233 is fixedly disposed at a position for grasping the test tube in the grip 232, so that the grip 232 can grip the test tube more firmly.
Referring to fig. 1 to 3, the shaking device further includes a first mounting plate 4, a second mounting plate 5 and a third driving assembly 6, wherein the third driving assembly 6 is a driving device composed of a motor and a synchronous belt assembly, and of course, in other embodiments, the third driving assembly 6 may also be other driving devices capable of providing a linear driving force, such as an air cylinder, a hydraulic cylinder, and the like, which is not limited by the present invention.
Fixed axle 11 rotate set up in on the first mounting panel 4, the stiff end of first drive assembly 13 and second drive assembly 14 all fixed set up in on the first mounting panel 4, first mounting panel 4 slide set up in on the second mounting panel 5, third drive assembly 6 is fixed set up in on the second mounting panel 5, third drive assembly 6's output with first mounting panel 4 is connected, with the drive first mounting panel 4 carries out elevating movement.
In this embodiment, after the staff placed the test tube on the test-tube rack, third drive assembly 6 will actuating mechanism 1 and tongs mechanism 2 move to the position of being level with the test tube, after grasping the test tube, third drive assembly 6 will actuating mechanism 1 and tongs mechanism 2 move to the settlement position, later, alright shake even work to the test tube, shake even completion back, third drive assembly 6 will tongs mechanism 2 moves to the position of being level with the test tube, is about to put the test tube back to the test-tube rack, compare in other embodiments, the degree of automation of shaking even device in this embodiment is higher, more laborsaving.
It should be noted that the shaking device may be used alone, or may be disposed in a medical detection device to be used in combination with other devices, which is not limited in the present invention.
With reference to fig. 1, as a preferred embodiment, the shaking up device further includes a slide rail 7, and the first mounting plate 4 is slidably disposed on the second mounting plate 5 through the slide rail 7. The slide rails 7 can make the first mounting plate 4 slide smoothly relative to the second mounting plate 5.
Based on the shaking device, the invention also provides a fluorescence immunoassay analyzer with the shaking device, the shaking device is arranged in the fluorescence immunoassay analyzer to shake test tubes entering the fluorescence immunoassay analyzer, wherein the specific working flow of the shaking device is described in detail above, and the invention is not repeated herein.
In conclusion, the shaking device provided by the invention has the following beneficial effects:
on one hand, the hand grab mechanism and the driving mechanism are arranged in the shaking-up device, when the test tube needs to be shaken up, a worker can complete the shaking-up work of the test tube only by using the hand grab mechanism and the driving mechanism in a matching way, and compared with the mode of shaking up the test tube manually in the prior art, the mode has higher automation degree and is more labor-saving;
on the other hand, the driving mechanism consisting of the fixed shaft, the pull rod, the first driving component and the second driving component in the shaking device has a compact structure and occupies a small space;
on the other hand, the hand grab mechanism composed of the mounting seat, the first sliding block and the two groups of hand grab components in the shaking device is more compact in structure.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any changes or substitutions that can be easily conceived by those skilled in the art within the technical scope of the present invention are included in the scope of the present invention.

Claims (10)

1. A shaking device is characterized by comprising a driving mechanism and a gripper mechanism, wherein the driving mechanism comprises a fixed shaft, a pull rod, a first driving assembly and a second driving assembly;
the end part of the fixed shaft is provided with a through hole in the axial direction, the pull rod is arranged in the through hole in a sliding manner, the output end of the first driving component is connected with one end of the pull rod so as to drive the pull rod to slide in the sliding stroke of the pull rod, and the other end of the pull rod is connected with the driving end of the gripper mechanism so as to drive the gripper mechanism to open or close in the sliding process;
the output end of the second driving component is connected with one end of the fixed shaft, and the other end of the fixed shaft is fixedly connected with the fixed end of the gripper mechanism to drive the gripper mechanism to swing back and forth in the swing stroke of the gripper mechanism.
2. The shake-up device according to claim 1, wherein the first driving assembly comprises a first driving member and a connecting member, an output end of the first driving member is fixedly connected with one end of the connecting member, and the other end of the connecting member is rotatably connected with one end of the pull rod to drive the pull rod to slide relative to the fixed shaft.
3. The shake-up device according to claim 1, wherein the second driving assembly comprises a second driving member, a transmission assembly and a control module, an output end of the second driving member is connected with the fixed shaft through the transmission assembly, and the control module is electrically connected with the second driving member so as to drive the gripper mechanism to swing back and forth around the fixed shaft through the second driving member.
4. The shake-up device according to claim 3, further comprising a sensing component, wherein the sensing component is fixedly arranged on one side of the gripping mechanism so as to generate a sensing signal when no test tube cover is arranged on the test tube held by the gripping mechanism.
5. The shake-up device according to claim 1, wherein the hand gripping mechanism comprises a mounting base, a first slider and two sets of hand gripping assemblies, the hand gripping assemblies comprise a second slider and a hand grip, and the second slider is fixedly connected with the hand grip;
one side of the mounting seat is fixedly connected with one end of the fixed shaft, the other side of the mounting seat is connected with the two second sliding blocks in a sliding mode, two sides of the first sliding block are connected with the two second sliding blocks in a sliding mode respectively, and the pull rod penetrates through the mounting seat and is fixedly connected with the first sliding block so as to drive the two second sliding blocks to be away from or close to each other.
6. The shake-up device according to claim 5, wherein the two second sliders are respectively formed with inclined slide grooves at opposite sides thereof, the first slider is provided between the two second sliders, and the two protrusion portions are respectively slidably provided in the two inclined slide grooves.
7. The shake-up device according to claim 5, wherein the hand grip assembly further comprises an elastic pad fixedly disposed in the hand grip at a position for gripping a test tube.
8. The shake-up device according to claim 1, further comprising a first mounting plate, a second mounting plate, and a third driving assembly, wherein the fixed shaft is rotatably disposed on the first mounting plate, the first driving assembly and the second driving assembly are both fixedly disposed on the first mounting plate, the first mounting plate is slidably disposed on the second mounting plate, and an output end of the third driving assembly is connected to the first mounting plate to drive the first mounting plate to perform an elevating motion.
9. The shake-up device according to claim 8, wherein the test tube shake-up device further comprises a slide rail, and the first mounting plate is slidably disposed on the second mounting plate through the slide rail.
10. A fluoroimmunoassay analyzer having the shaking device, comprising the shaking device according to any one of claims 1 to 9.
CN202210335175.2A 2022-03-31 2022-03-31 Shake even device and have this fluorescence immunoassay appearance that shakes even device Pending CN114733406A (en)

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CN202210335175.2A CN114733406A (en) 2022-03-31 2022-03-31 Shake even device and have this fluorescence immunoassay appearance that shakes even device

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CN202210335175.2A CN114733406A (en) 2022-03-31 2022-03-31 Shake even device and have this fluorescence immunoassay appearance that shakes even device

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CN115445489A (en) * 2022-08-10 2022-12-09 武汉大学 Heparin tube mixing appearance

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Publication number Priority date Publication date Assignee Title
CN115445489A (en) * 2022-08-10 2022-12-09 武汉大学 Heparin tube mixing appearance
CN115366087A (en) * 2022-08-23 2022-11-22 四川微康朴澜医疗科技有限责任公司 Mixing mechanical arm for fluorescence immunoassay analyzer

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