CN114732851A - 一种通脉散寒止痛丸、制备方法及其应用 - Google Patents

一种通脉散寒止痛丸、制备方法及其应用 Download PDF

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CN114732851A
CN114732851A CN202210450124.4A CN202210450124A CN114732851A CN 114732851 A CN114732851 A CN 114732851A CN 202210450124 A CN202210450124 A CN 202210450124A CN 114732851 A CN114732851 A CN 114732851A
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孟庆威
邢宏艳
孟鹭
曲尧
周野
刘芫君
杜淑娟
王洋
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Bizhigao Pharmaceutical Co ltd
Former Guoshenghe Hospital
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Abstract

本发明公开了一种通脉散寒止痛丸、制备方法及其应用，所述通脉散寒止痛丸以白芍养血平肝、柔筋缓急为君药；配伍威灵仙、槲寄生、伸筋草、葛根以及骨碎补，通达表里、舒筋通络；乳香、没药以及当归，活血化瘀、止痛共为臣药；配伍肉桂，温经散寒，使寒凝得解，经络得通，又可以佐白芍酸寒之弊为佐药，配伍甘草既可调和诸药，又有缓急止痛之效，为使药。诸药相伍，共奏温通经脉，养血散寒止痛之功；该通脉散寒止痛丸，适用于治疗椎间盘突出、椎管狭窄、骨质增生所致的腰腿痛、颈肩臂痛、冷感、麻木等神经症状，在温通经脉，养血散寒止痛等方面疗效显著。

Description

一种通脉散寒止痛丸、制备方法及其应用
技术领域
本发明公开涉及中药的技术领域，尤其涉及一种通脉散寒止痛丸、制备方法及其应用。
背景技术
随着现代生活方式的改变以及生活节奏的加快，人们遭受风寒湿邪侵袭的机会也有所增加，极易引发骨质增生、腰椎盘突出、椎管狭窄类疾病。以往骨质增生、腰椎盘突出、椎管狭窄等病主要发生在老年人身上，而近几年发现，上述疾病的发病年龄不断提前。
骨质增生、腰椎盘突出、椎管狭窄类疾病属于人体组织的退行性改变，通常是持久、顽固、难以终止或逆转的，因此，导致上述疾病的发病、进展、复发等各项指标居高不降，成为医学界公认的一大难题。
因此，如何研发一种治疗骨质增生或腰椎盘突出类疾病的有效药物，成为人们亟待解决的问题。
发明内容
鉴于此，本发明提供了一种通脉散寒止痛丸、制备方法及其应用，以提供一种可有效治疗骨质增生、腰椎盘突出、椎管狭窄类疾病的药物。
一方面，本发明提供了一种通脉散寒止痛丸，按重量计，该通脉散寒止痛丸由以下原料制成：白芍140-160份、威灵仙110-130份、槲寄生90-110份、伸筋草70-90份、葛根70-90份、骨碎补90-110份、醋乳香50-70份、当归80-100份、肉桂70-90份以及甘草80-100份。
优选，所述通脉散寒止痛丸，按重量计，由以下原料制成：白芍150份、威灵仙120份、槲寄生100份、伸筋草80份、葛根80份、骨碎补100份、醋乳香60份、当归90份、肉桂80份以及甘草90份。
另一方面，本发明还提供了一种上述通脉散寒止痛丸的制备方法，该方法包括如下步骤：
将白芍、威灵仙、槲寄生、伸筋草、葛根、骨碎补、醋乳香、当归、肉桂以及甘草粉碎后，过筛备用；
按比例取上述备用原料混匀，用水泛丸，干燥，得成品。
此外，本发明还提供了一种通脉散寒止痛丸的应用，具体而言，将所述通脉散寒止痛丸用于治疗椎间盘突出、椎管狭窄、骨质增生所致的腰腿痛、颈肩臂痛、冷感、麻木神经症状。
本发明提供的通脉散寒止痛丸，以白芍养血平肝、柔筋缓急为君药；配伍威灵仙、槲寄生、伸筋草、葛根以及骨碎补，通达表里、舒筋通络；乳香、没药以及当归，活血化瘀、止痛共为臣药；配伍肉桂，温经散寒，使寒凝得解，经络得通，又可以佐白芍酸寒之弊为佐药，配伍甘草既可调和诸药，又有缓急止痛之效，为使药。诸药相伍，共奏温通经脉，养血散寒止痛之功。
本发明提供的通脉散寒止痛丸，适用于治疗椎间盘突出、椎管狭窄、骨质增生所致的腰腿痛、颈肩臂痛、冷感、麻木等神经症状，在温通经脉，养血散寒止痛等方面疗效显著。
应当理解的是，以上的一般描述和后文的细节描述仅是示例性和解释性的，并不能限制本发明的公开。
具体实施方式
下面结合具体实施方案对本发明进行进一步解释说明，但是并不用于限制本发明的保护范围。
本实施方案提供了一种可有效治疗骨质增生、腰椎盘突出、椎管狭窄类疾病的通脉散寒止痛丸，具体而言，该通脉散寒止痛丸由以下成分制成：白芍140-160g、威灵仙110-130g、槲寄生90-110g、伸筋草70-90g、葛根70-90g、骨碎补90-110g、醋乳香50-70g、当归80-100g、肉桂70-90g以及甘草80-100g；优选的质量配比为：白芍150g、威灵仙120g、槲寄生100g、伸筋草80g、葛根80g、骨碎补100g、醋乳香60g、当归90g、肉桂80g以及甘草90g。
上述通脉散寒止痛丸，以白芍养血平肝、柔筋缓急为君药；配伍威灵仙、槲寄生、伸筋草、葛根以及骨碎补，通达表里、舒筋通络；乳香、没药以及当归，活血化瘀、止痛共为臣药；配伍肉桂，温经散寒，使寒凝得解，经络得通，又可以佐白芍酸寒之弊为佐药，配伍甘草既可调和诸药，又有缓急止痛之效，为使药。诸药相伍，共奏温通经脉，养血散寒止痛之功。
上述通脉散寒止痛丸的具体制备步骤如下：
将白芍、威灵仙、槲寄生、伸筋草、葛根、骨碎补、醋乳香、当归、肉桂以及甘草粉碎后，过筛备用；
按比例取上述备用原料混匀，用水泛丸，干燥，得成品。
采用上述方法制备获得的通脉散寒止痛丸为棕色或棕褐色的水丸，气微香，味微苦。
上述通脉散寒止痛丸主要用于治疗椎间盘突出、椎管狭窄、骨质增生所致的腰腿痛、颈肩臂痛、冷感、麻木的神经症状。
服用方式为：口服，一次6g，一日3次，温水送服。
下面结合具体实施例对本发明进行更进一步的解释说明，但是并不限制本发明的保护范围。
为了验证上述通脉散寒止痛丸的药效，近三年来工治疗3524例，其中，男性1756例，女性1768例，男女比例约为1:1，年龄最小者10岁、最大者72岁，具体见表1。
表1：
10～18岁 19～40岁 41～60岁 61～72岁
781例 1124例 1349例 270例
治疗各种疾病病例数，见表2。
表2：
寒凝经脉骨性关节炎 瘀血阻络骨性关节炎 椎管狭窄 椎间盘突出
193例 1864例 134例 1333例
1)药物配方：
白芍150g、威灵仙120g、槲寄生100g、伸筋草80g、葛根80g、骨碎补100g、醋乳香60g、当归90g、肉桂80g以及甘草90g。
2)制备方法：
将白芍、威灵仙、槲寄生、伸筋草、葛根、骨碎补、醋乳香、当归、肉桂以及甘草粉碎后，过筛备用；按比例取上述备用原料混匀，用水泛丸，干燥，得成品。
3)疗效标准：
根据患者病情，每次服用一袋(6g/袋)，一日3次，治疗21天为一个疗程，一般为1～3个疗程。
治愈：经过1～3个疗程治疗，患者临床症状消失，随访半年未复发。
显效：经过1～3个疗程治疗，临床症状大部分消失或消失后一个月内复发者。
无效：经过3个疗程治疗部分临床症状消失或无改善者。
详细治疗效果数据，见表3-表6。
表3：
Figure BDA0003616907120000041
表4：
Figure BDA0003616907120000042
表5：
Figure BDA0003616907120000043
表6：
Figure BDA0003616907120000044
Figure BDA0003616907120000051
由上述治疗效果数据可知，通脉散寒止痛丸在治疗寒凝经脉、瘀血阻络所致的骨性关节炎，症见关节肿胀、麻木、疼痛、活动受限；椎管狭窄、椎间盘突出见上述证候者等病症中，临床总有效率为99.2％，无效率为0.8％。三年来经过随访未见毒副作用及明显不良反应。
本领域技术人员在考虑说明书及实践这里公开的发明后，将容易想到本发明的其它实施方案。本申请旨在涵盖本发明的任何变型、用途或者适应性变化，这些变型、用途或者适应性变化遵循本发明的一般性原理并包括本发明未公开的本技术领域中的公知常识或惯用技术手段。说明书和实施例仅被视为示例性的，本发明的真正范围和精神由下面的权利要求指出。
应当理解的是，本发明并不局限于上面已经描述的内容，并且可以在不脱离其范围进行各种修改和改变。本发明的范围仅由所附的权利要求来限制。

Claims (4)

1.一种通脉散寒止痛丸，其特征在于，按重量计，由以下原料制成：白芍140-160份、威灵仙110-130份、槲寄生90-110份、伸筋草70-90份、葛根70-90份、骨碎补90-110份、醋乳香50-70份、当归80-100份、肉桂70-90份以及甘草80-100份。
2.一种通脉散寒止痛丸，其特征在于，按重量计，由以下原料制成：白芍150份、威灵仙120份、槲寄生100份、伸筋草80份、葛根80份、骨碎补100份、醋乳香60份、当归90份、肉桂80份以及甘草90份。
3.一种权利要求1或2所述通脉散寒止痛丸的制备方法，其特征在于，包括如下步骤：
将白芍、威灵仙、槲寄生、伸筋草、葛根、骨碎补、醋乳香、当归、肉桂以及甘草粉碎后，过筛备用；
按比例取上述备用原料混匀，用水泛丸，干燥，得成品。
4.一种权利要求1或2所述通脉散寒止痛丸的应用，其特征在于，所述通脉散寒止痛丸用于治疗椎间盘突出、椎管狭窄、骨质增生所致的腰腿痛、颈肩臂痛、冷感、麻木神经症状。
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Citations (1)

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Publication number Priority date Publication date Assignee Title
CN101108210A (zh) * 2006-07-21 2008-01-23 黄振华 一种治疗颈椎病的药物

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101108210A (zh) * 2006-07-21 2008-01-23 黄振华 一种治疗颈椎病的药物

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