CN114732519A - Method for accurate positioning and navigation of individual space transcranial magnetic stimulation based on magnetic resonance imaging - Google Patents
Method for accurate positioning and navigation of individual space transcranial magnetic stimulation based on magnetic resonance imaging Download PDFInfo
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- 238000002599 functional magnetic resonance imaging Methods 0.000 claims abstract description 6
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- A61B34/20—Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
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Abstract
The invention belongs to the field of biomedical image mode identification, and provides a magnetic resonance imaging-based individual space transcranial magnetic stimulation accurate positioning navigation method, which comprises the following steps: acquiring resting state functional magnetic resonance imaging and high-resolution T1 weighted structure imaging of a patient; matching the structural image with the functional image, and searching for the region of the target nucleus; performing whole brain function connection calculation by taking the target nucleus area as a seed point, and searching an area functionally connected with the target nucleus in the cortex area to construct a target point; step four, generating an individual template with a target mark; and fifthly, guiding the individual template with the target mark into an accurate navigation TMS instrument. In the invention, the individual target points are helpful for accurate intervention of TMS according to the characteristics of individuals, and provide clear guidance for clinical use of intervention measures for specified mental diseases.
Description
Technical Field
The invention belongs to the field of biomedical image mode identification, and particularly relates to a magnetic resonance imaging-based individual space transcranial magnetic stimulation accurate positioning navigation method.
Background
Functional magnetic resonance imaging (fMRI) is a noninvasive neuroimaging means that utilizes the different paramagnetic properties of oxygenated hemoglobin and deoxygenated hemoglobin. Numerous studies have found that the process of cooperative changes between different regions of the brain in the resting state, i.e. the intensity and changes of resting state functional connectivity (rsFC), is closely related to demographic variables, mood, memory, cognitive abilities and disease characteristics.
Transcranial Magnetic Stimulation (TMS) is a non-destructive nerve Stimulation technology, which utilizes a pulsed Magnetic field to act on the central nervous system (mainly the brain) to change the membrane potential of cortical nerve cells, so that induced current is generated to influence the metabolism in the brain and the nerve electrical activity, thereby causing a series of physiological and biochemical reactions. In brief, TMS can painlessly and non-invasively generate inductive currents that activate the cortex, thereby altering physiological processes within the brain. Because TMS can stimulate and modulate neural activity in specific brain regions, it is now widely used in the treatment and intervention of various psychiatric disorders. However, traditional TMS only hits the brain subcortically in areas 2-3 cm, and does not provide a good treatment for most patients with mental disorders in the affected deep areas, such as the thalamus, amygdala, etc. In contrast, Deep Brain Stimulation (DBS) is the most commonly used invasive therapy for Deep nuclear mass therapy. DBS has evolved over the past 20 years as an alternative to the destructive surgery commonly used in traditional stereotactic functional neurosurgery. The method has proved to be an effective method, and the disability rate of the operation is greatly reduced due to the characteristics of reversibility and adjustability. The surgical method is initially applied to the treatment of dyskinesia, and the frequently selected target sites are thalamus, globus pallidus and subthalamic nucleus. However, due to the invasive nature of DBS, this approach cannot be used extensively in a wide range of psychiatric disorders.
Although the existing therapeutic measures have relatively fixed target areas, for example, in the therapeutic intervention of autism, the left and right dorsolateral prefrontal lobes are generally adopted as the intervention targets, but due to individual differences and disease heterogeneity, the effect of TMS is often not very satisfactory, and in the related therapy of TMS, more precise individual targets are lacked.
Disclosure of Invention
The invention aims to solve the problems recorded in the background technology and provides a method for accurate positioning and navigation of individual space transcranial magnetic stimulation based on magnetic resonance imaging.
In order to achieve the purpose, the invention adopts the following technical scheme: a method for accurate positioning and navigation of individual space transcranial magnetic stimulation based on magnetic resonance imaging comprises the following steps:
acquiring resting state functional magnetic resonance imaging and high-resolution T1 weighted structure imaging of a patient to acquire a functional image and a structural image of an individual space;
matching the structural image with the functional image, and searching for the region of the target nucleus;
performing whole brain function connection calculation by taking the target nucleus area as a seed point, and searching an area functionally connected with the target nucleus in the cortex area to construct a target point;
generating an individual template with a target mark;
and fifthly, guiding the individual template with the target mark into an accurate navigation TMS instrument.
In a preferred embodiment of the present invention, in step two, the structural image is registered to the corresponding functional image individual space, or the functional image is registered to the individual structural space.
In a preferred embodiment of the present invention, in step two, the matching method is: and selecting a preset standard structure or function partition brain template, carrying out inverse transformation on the brain template, and carrying out inverse registration from a standard MNI space to an individual space.
In a preferred embodiment of the present invention, in step three, the calculation formula of the whole brain function connection calculation is as follows:
wherein xiAnd xjRepresenting the time series of two regions of interest, t denotes the point in time.
The principle and the beneficial effects of the invention are as follows: the invention provides a brain image-based individual space accurate target positioning method for assisting clinical determination of a stimulation target, aiming at the clinical problems that TMS is difficult to stimulate a brain subcutaneous deep nucleus and individual differences are large. The individual targets are helpful for accurate intervention of TMS aiming at the characteristics of individuals, and provide clear guidance for clinical use of intervention measures for specified mental diseases. The method indirectly acts on the deep nucleus area by accurately stimulating the target spot by utilizing the relation of the functional connection loop, and provides more effective individualized treatment navigation for TMS image navigation.
Therefore, based on the current research situation, the invention adopts a method for constructing the individualized target spot based on magnetic resonance imaging, and solves the problems that the conventional TMS can not stimulate deep nuclear groups, DBS is invasive, the individual variability is large, and the like. The method is characterized in that a target nucleus based whole brain function connection is constructed in an individual space, and a cortical region target spot most closely related to the target nucleus is searched. And an accurate target spot which is more in line with the actual situation of each individual is constructed at the individual level, and the accurate target spot indirectly acts on a deep stratum region which is difficult to hit by TMS, so that a new effective method is provided for the designation of individual TMS treatment measures.
Additional aspects and advantages of the invention will be set forth in part in the description which follows and, in part, will be obvious from the description, or may be learned by practice of the invention.
Drawings
The above and/or additional aspects and advantages of the present invention will become apparent and readily appreciated from the following description of the embodiments, taken in conjunction with the accompanying drawings of which:
fig. 1 is a schematic flow chart of a method for accurate positioning and navigation of individual space through cranial magnetic stimulation based on magnetic resonance imaging in the invention.
FIG. 2 is a schematic diagram of the whole brain individualized functional connection with amygdala as the seed point in the present invention.
FIG. 3 is an individual template with a precise target of the present invention.
Detailed Description
Reference will now be made in detail to embodiments of the present invention, examples of which are illustrated in the accompanying drawings, wherein like or similar reference numerals refer to the same or similar elements or elements having the same or similar function throughout. The embodiments described below with reference to the accompanying drawings are illustrative only for the purpose of explaining the present invention, and are not to be construed as limiting the present invention.
In the description of the present invention, it is to be understood that the terms "longitudinal", "lateral", "vertical", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc. indicate orientations or positional relationships based on those shown in the drawings, merely for convenience of description and simplicity of description, and do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, are not to be construed as limiting the present invention.
In the description of the present invention, unless otherwise specified and limited, it is to be noted that the terms "mounted," "connected," and "connected" are to be interpreted broadly, and may be, for example, a mechanical connection or an electrical connection, a communication between two elements, a direct connection, or an indirect connection via an intermediate medium, and specific meanings of the terms may be understood by those skilled in the art according to specific situations.
The application provides a method for accurate positioning and navigation of individual space transcranial magnetic stimulation based on magnetic resonance imaging, and the method is applied to 1 patient with childhood autism by trial clinical research, as shown in the attached figure 1, and comprises the following steps:
the method comprises the following steps: acquiring resting state functional magnetic resonance imaging and high-resolution T1 weighted structure imaging of a patient to acquire a functional image and a structural image of an individual space;
step two: since the structural and functional images are scanned separately and the patient is moving during scanning, although their brains are images of the same individual space, there are some differences, so it is necessary to register the structure and function, i.e. to register the structural image of each person in the corresponding individual space of the functional image (or to register the functional image in the individual structural space), and to match the functional space and the structural space of the brain of each person together. Then, a brain partition template of an individual space is obtained, specifically: and selecting a preset standard structure or function partition brain template. The brain template is inverse-transformed from the standard MNI space into the individual space, for example: and selecting the structural image of the individual space to be matched with the functional image, and then performing inverse registration from the standard MNI space to the structural image of the individual space, and otherwise, selecting the functional image of the individual space to be matched with the structural image, and then performing inverse registration from the standard MNI space to the functional image of the individual space.
Step three: selecting corresponding deep nucleus area from brain partition template of individual space according to clinical requirement, and using the deep nucleus area of individual as seed point to make whole brain function connection. In the experiment, we used the individual amygdala region as the seed point for the calculation of the Functional Connectivity (FC) (as shown in fig. 2):
wherein xiAnd xjRepresenting two Regions of interest, ROI), and t represents a point in time.
According to actual clinical requirements and research hypothesis, selecting corresponding cortical regions in an individual space, and searching regions with strongest functional connection with a target nucleus as target spots. In the experiment, we made a standard template of the dorsolateral prefrontal lobe (DLPFC) according to the actual hypothesis, registered it into the individual space, and searched for the region with the strongest functional connection with amygdala in the DLPFC region for each patient (as shown in fig. 3).
Step four: and selecting the area with the strongest functional connection as a target accurate target point, and making and generating a structural image with a target point mark based on the individual structural imaging.
Step five: and (3) guiding the individual template with the target mark into a TMS instrument with accurate navigation, and providing more accurate and effective target spots for the individual to treat.
In the description herein, reference to the description of the terms "preferred embodiment," "one embodiment," "some embodiments," "an example," "a specific example" or "some examples" or the like means that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, the schematic representations of the terms used above do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.
While embodiments of the invention have been shown and described, it will be understood by those of ordinary skill in the art that: various changes, modifications, substitutions and alterations can be made to the embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the claims and their equivalents.
Claims (4)
1. The method for accurate positioning and navigation of individual space transcranial magnetic stimulation based on magnetic resonance imaging is characterized by comprising the following steps:
acquiring resting state functional magnetic resonance imaging and high-resolution T1 weighted structure imaging of a patient to acquire a functional image and a structural image of an individual space;
matching the structural image with the functional image, and searching for the region of the target nucleus;
performing whole brain function connection calculation by taking the target nucleus area as a seed point, and searching an area functionally connected with the target nucleus in the cortex area to construct a target point;
generating an individual template with a target mark;
and fifthly, guiding the individual template with the target mark into an accurate navigation TMS instrument.
2. The method for accurate positioning and navigation through magnetic resonance imaging based on spatial transcranial magnetic stimulation of an individual according to claim 1, wherein in the second step, the structural image is registered to the corresponding functional image, or the functional image is registered to the structural image.
3. The method for accurate positioning and navigation of individual space through cranial magnetic stimulation based on magnetic resonance imaging as claimed in claim 2, wherein in the second step, the matching mode is: and selecting a preset standard structure or function partition brain template, carrying out inverse transformation on the brain template, and carrying out inverse registration from a standard MNI space to an individual space.
4. The method for accurate positioning and navigation through spatial transcranial magnetic stimulation of an individual based on magnetic resonance imaging as claimed in claim 3, wherein in step three, the calculation formula of the whole brain function connection calculation is as follows:
wherein xiAnd xjRepresenting the time series of two regions of interest, t denotes the point in time.
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Cited By (3)
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| CN116492600A (en) * | 2023-06-28 | 2023-07-28 | 南昌大学第一附属医院 | Regulation and control device, equipment and storage medium based on individuation time-space target |
| CN116504363A (en) * | 2023-05-10 | 2023-07-28 | 中国科学院心理研究所 | Depression TMS individuation target spot positioning method and system based on group level difference statistical diagram |
| CN116543042A (en) * | 2023-05-10 | 2023-08-04 | 中国科学院心理研究所 | Depression TMS individuation target spot positioning method and system based on group level average statistical diagram |
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