CN114729322A - 用于将细胞重新程序化成浆细胞样树突细胞或i型干扰素产生细胞的组合物、方法及其用途 - Google Patents

用于将细胞重新程序化成浆细胞样树突细胞或i型干扰素产生细胞的组合物、方法及其用途 Download PDF

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CN114729322A
CN114729322A CN202080080049.6A CN202080080049A CN114729322A CN 114729322 A CN114729322 A CN 114729322A CN 202080080049 A CN202080080049 A CN 202080080049A CN 114729322 A CN114729322 A CN 114729322A
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C·F·雷蓓罗勒莫斯佩雷拉
C·弗雷拉皮雷斯
F·弗乌扎洛萨
A·奥特曼
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Abstract

本公开内容涉及用于将细胞重新程序化成浆细胞样树突细胞或I型干扰素产生细胞的组合物、构建体和载体，方法及其用途。本公开内容涉及用于通过引入和表达分离的/合成的转录因子来从分化的、多潜能或多能干细胞制备浆细胞样树突细胞或I型干扰素产生细胞(其促进抗病毒和抗肿瘤免疫应答)的方法的开发。更具体地，本公开内容提供了通过用特定转录因子的组合的惊人应用进行直接细胞重新程序化而获得浆细胞样树突细胞或I型干扰素产生细胞的方法。

Description

用于将细胞重新程序化成浆细胞样树突细胞或I型干扰素产 生细胞的组合物、方法及其用途
技术领域
本公开内容涉及用于将细胞重新程序化成浆细胞样树突细胞或I型干扰素产生细胞的组合物、方法及其用途。
本公开内容涉及用于通过引入和表达分离的/合成的转录因子来从分化的、多潜能或多能干细胞制备浆细胞样树突细胞或I型干扰素产生细胞(其促进免疫抗病毒和抗肿瘤应答)的方法的开发。更具体地，本公开内容提供了通过用特定转录因子的组合的惊人有益应用进行直接细胞重新程序化而获得浆细胞样树突细胞或I型干扰素产生细胞的方法。
背景
细胞重新程序化依赖于将一种细胞状态的表观遗传和转录网络重新连接到不同细胞类型的表观遗传和转录网络。转录因子(TF)-转导实验已强调了成体体细胞或分化的细胞的可塑性，从而提供了生成任何期望细胞类型的新技术。通过TF的强制表达，可能将体细胞或分化的细胞重新程序化为与胚胎干细胞非常相似的诱导型多能干细胞(iPSC)(Takahashi等人,2006；Takahashi等人,2007)。可替换地，还可以将体细胞转化为另一种特化细胞类型(Pereira等人,2012)。使用规定靶细胞身份的TF，已证明直接谱系转化成功地将小鼠和人成纤维细胞重新程序化为几种细胞类型，诸如神经元、心肌细胞和肝细胞(Xu等人,2015)。还在造血系统中证实了谱系转化，其中TF的强制表达诱导了B细胞和成纤维细胞中的巨噬细胞命运(Xie等人,2004)，并且用转录因子Gata2、Gfi1b、cFos和Etv6实现了将小鼠成纤维细胞直接重新程序化为克隆原性的造血祖细胞(Pereira等人,2013)。这四种TF诱导动态的多阶段造血过程，其通过内皮样中间体进展，在体外重演发育血细胞生成(Pereira等人,2016)。
重新程序化的细胞对于再生医学而言是非常有前途的治疗工具，并且已在临床研究中测试了通过iPSC的分化获得的细胞。
细胞重新程序化策略已经强调了细胞命运的灵活性，可能使用细胞类型特异性的TF将体细胞转化为多能性。一种分化的细胞类型向另一种的直接谱系转化也已被证明和探索，以阐明细胞生物学机制和用于再生医学目的。近年来，我们已经证实，抗原呈递树突细胞(DC)可以通过TF的小组合从不相关的细胞类型重新程序化(Rosa等人,2018)。经典地，有人认为，骨髓DC定向祖细胞产生在功能上不同的DC子集：常规DC(cDC)和浆细胞样DC(pDC)。cDC是驱动抗原特异性免疫应答的专业抗原呈递细胞(APC)，而pDC是在病毒感染期间I型干扰素的专业生产者。它们表现出先天性和适应性免疫功能，并可以作为直接影响T细胞应答的APC起作用。在DC发育期间调节不同子集的分歧的时机和确切机制仍有待确定。
文件EP 3 385 373涉及用于细胞诱导或将细胞重新程序化为常规树突细胞状态或抗原呈递细胞状态的组合物、核酸构建体、方法及其试剂盒，其部分基于在该文件中描述的惊人效果：允许将分化的或未分化的细胞诱导或重新程序化为DC或APC的转录因子组合的新型用途。
在文件EP 3 385 373中描述的转录因子的组合诱导具有DC的cDC1子集特有的表面表型、转录标记和功能特性的DC。以前没有描述过分泌I型干扰素例如干扰素α(IFN-α)和β(IFN-β)的能力。
本文描述的诱导的pDC或I型干扰素产生细胞概括了检测核酸和通过分泌I型干扰素作出应答的典型pDC功能特性(Reizis 2019)。
公开这些事实是为了说明本公开内容所解决的技术问题。
发明内容
本发明主题鉴定了几种分离的转录因子，它们令人惊讶地在体外、离体或在体内将分化的细胞、多潜能或多能干细胞重新程序化或诱导成pDC或I型干扰素产生细胞。
令人惊讶的是，通过如本公开内容中所述的重新程序化产生的诱导的pDC或I型干扰素产生细胞固有地能够分泌诱导抗病毒或抗肿瘤应答所需的I型干扰素。
令人惊讶的是，通过如本公开内容中所述的重新程序化产生的诱导的pDC或I型干扰素产生细胞固有地能够通过分泌增加的量的诱导抗病毒应答所需的I型干扰素(例如干扰素α(IFN-α)和β(IFN-β))而对toll-样受体7(TLR7)和TLR9配体做出应答。
DC是遍布全身的专业APC，其在先天性和适应性免疫系统的界面处发挥功能。DC通过其捕获、处理在主要组织相容性复合物(MHC)I类和MHC II类分子上负载的抗原并将其呈递给T细胞从而将它们靶向至不同类型的免疫应答的能力，能够提供外部环境和适应性免疫系统之间的关键联系。首先，DC必须捕获抗原并通过主要组织相容性复合物(MHC)I类和MHC II类处理它们。在其活化后，DC能够向局部引流淋巴结迁移，从而引发多种B细胞和T细胞应答，这是适应性免疫的一个关键特征。早期保护效力主要是通过诱导B淋巴细胞产生的抗原特异性抗体来赋予。针对特定抗原的长期保护需要特异性抗体的持久性和免疫记忆的产生，所述免疫记忆可以在随后的抗原暴露以后提供快速且有效的应答。DC作为专业的APC具有交叉呈递抗原的能力，这意味着，除了其经典的在MHC II类上呈递外源性抗原和在MHCI类上呈递内源性抗原的能力外，它们还能够在MHC I类上呈递外源性抗原，这是产生细胞毒性T淋巴细胞应答(CTL)的关键步骤。
个体发育和/或DC所在的微环境可能导致DC对表面受体的独特组合的表达。例如，表型标准允许将小鼠DC分类为不同的亚群。其中，淋巴组织中的cDC传统上被细分为cDC1和cDC2亚群。有人认为，不同的DC子集可能参与某些病原体的特异性识别和/或调节不同的免疫应答，例如Th1或Th2(免疫)或调节性T细胞(耐受性)。但是，DC的表型和功能行为也受到外部活化刺激的显著调理，表明显著的可塑性。cDC1和cDC2子集在体内不同地引发Th1和Th2应答。癌症的免疫疗法依赖于使用DC以引发Th1或细胞毒性T淋巴细胞应答以促进肿瘤清除。与cDC一起，pDC作为一个独特的DC子集出现，在病毒感染或通过TLR7和TLR9识别自身核酸后专门生产I型干扰素(IFN)。除了有助于抗病毒免疫外，pDC还可以参与免疫原性的和致耐受性的适应性免疫应答的引发，这与自身免疫性疾病和癌症的病理学有关。
pDC具有响应于病毒和/或病毒衍生的核酸产生比任何其它细胞类型更多的I型干扰素的独特特征。TLR7和9在pDC中、在细胞内的胞内体隔室中高度表达。TLR7识别病毒单链RNA，且TLR9检测富含未甲基化的CpG寡核苷酸的病毒双链DNA。在被病毒核酸活化后，它们诱导衔接蛋白MyD88和两种主要的TLR7/9细胞内信号传导途径的刺激和募集。第一个途径导致I型干扰素产生，这需要IRF7易位至细胞核，从而促进IFN-α和IFN-β转录和分泌。I型干扰素(由pDC在被核酸活化后分泌)能够连接先天性和适应性免疫系统，从而促进长期T-细胞存活和记忆,Th1极化、CD8 T-细胞细胞裂解活性、NK细胞介导的细胞毒性和B-细胞生长和分化。可替换地，第二途径的活化导致促炎细胞因子TNF-α和IL-6、以及趋化因子例如CXCL9(MIG)、CXCL10(IP-10)、CCL3(MIP-1a)、CCL4(MIP-1b)和CCL5(RANTES)的表达的NF-kb依赖性诱导。这些进而能够将活化的CD4和CD8 T细胞吸引到炎症部位。
目前，基于DC的免疫疗法依赖于自体DC前体：与效率较低的DC的产生相关的单核细胞，或以非常低的数目分离的造血祖细胞。此外，这些前体细胞通常在患有癌症的患者中受到损害，从而导致功能失调的DC和异质DC的混合物的产生。相反，非造血细胞类型诸如成纤维细胞通常不受影响。人真皮成纤维细胞(HDF)还表现出其它竞争优势；它们容易从小皮肤穿刺活检样品中获得，容易在体外扩增几代(4周后1500-2000万个细胞)，并且可以冷冻保存并按需使用。鉴于DC在先天性和适应性免疫系统的界面上发挥作用的基本作用，临床仍需要寻找替代策略来产生功能性pDC的同质群体以引发抗原特异性应答。
近年来，pDC由于能够产生大量IFN和启动T细胞而引起了特别兴趣。由于CD4+和CD8+T细胞应答受损，pDC-缺陷型小鼠被显示不能高效地清除淋巴细胞性脉络丛脑膜炎病毒(Cervantes-Barragan等人,2012)。类似地，据报告，患者中IRF7的无效突变负面地影响pDC对I型和III型IFN的产生，这导致严重的流感感染(Ciancanelli等人,2015)。这些发现指示，pDC对抵抗病毒感染是重要的，尤其是在早期阶段(Swiecki和Colonna,2015)，此时IFN产生可以限制病毒复制。此外，几个临床试验已经探索了pDC诱导抗肿瘤免疫应答的潜力(Tel等人,2013)。但是，pDC的治疗用途似乎受限于在血液中循环的这些细胞的低数目。因此，需要DC、特别是pDC的替代来源来满足治疗需求。
在一些实施方案中，与具有多肽序列(SEQ.ID.49-SEQ.ID.96)的参考多肽或由序列SEQ.ID.1-SEQ.ID.48编码的多肽具有相同或类似活性的多肽变体或家族成员可以用在本文所述的组合物、方法和试剂盒中。通常，用于本文所述的组合物、载体、构建体、方法和试剂盒中的编码pDC诱导因子的特定多肽的变体将与该特定参考多核苷酸或多肽具有至少约90％、至少约91％、至少约92％、至少约93％、至少约94％、至少约95％、至少约96％、至少约97％、至少约98％、至少约99％或更多序列同一性，如通过本文描述的和本领域技术人员已知的序列比对程序和参数所确定。
用于比较的序列比对方法是本领域众所周知的，这样的方法包括GAP、BESTFIT、BLAST、FASTA和TFASTA。GAP使用Needleman和Wunsch的算法((1970)J Mol Biol 48:443-453)以寻找两个序列的总体(在整个序列中)比对，其使匹配数最大化并使缺口数最小化。BLAST算法(Altschul等人(1990)J Mol Biol 215:403-10)计算序列同一性百分比并执行两个序列之间的相似性的统计学分析。用于执行BLAST分析的软件可以通过国立生物技术信息中心(National Centre for Biotechnology Information，NCBI)公开获得。使用MatGAT软件包中可得到的方法之一，也可以确定相似性和同一性的总体百分比(Campanella等人,BMC Bioinformatics.2003年7月10日；4:29.MatGAT:an applicationthat generates similarity/identity matrices using protein or DNA sequences)。如本领域技术人员显而易见的，可以进行少量手动编辑以优化保守基序之间的比对。使用BLAST和默认参数在整个氨基酸或核苷酸序列上确定在本发明主题中作为百分比指示的序列同一性值。
在一个实施方案中，为了更好的结果，所述转录因子可以由选自以下的多核苷酸编码：IRF8(SEQ.ID.1,SEQ.ID.2)、SPIB(SEQ.ID.3,SEQ.ID.4)、ARID5A(SEQ.ID.5,SEQ.ID.6)、BCL11A(SEQ.ID.7,SEQ.ID.8)、CBFA2T3(SEQ.ID.9,SEQ.ID.10)、CREB3L2(SEQ.ID.11,SEQ.ID.12)、ETS1(SEQ.ID.13,SEQ.ID.14)、HDAC5(SEQ.ID.15,SEQ.ID.16)、HHEX(SEQ.ID.17,SEQ.ID.18)、HOXA5(SEQ.ID.19,SEQ.ID.20)、ID3(SEQ.ID.21,SEQ.ID.22)、IKZF1(SEQ.ID.23,SEQ.ID.24)、IKZF2(SEQ.ID.25,SEQ.ID.26)、IKZF3(SEQ.ID.27,SEQ.ID.28)、IKZF5(SEQ.ID.29,SEQ.ID.30)、IRF7(SEQ.ID.31,SEQ.ID.32)、MEF2C(SEQ.ID.33,SEQ.ID.34)、MYB(SEQ.ID.35,SEQ.ID.36)、RUNX2(SEQ.ID.37,SEQ.ID.38)、STAT3(SEQ.ID.39,SEQ.ID.40)、TCF4(SEQ.ID.41,SEQ.ID.42)、TCF12(SEQ.ID.43,SEQ.ID.44)、STAT1(SEQ.ID.45,SEQ.ID.46)和TSC22D1(SEQ.ID.47,SEQ.ID.48)。
在本公开内容的一个实施方案中，所述转录因子可以选自：IRF8(SEQ.ID.49,SEQ.ID.50)、SPIB(SEQ.ID.51,SEQ.ID.52)、ARID5A(SEQ.ID.53,SEQ.ID.54)、BCL11A(SEQ.ID.55,SEQ.ID.56)、CBFA2T3(SEQ.ID.57,SEQ.ID.58)、CREB3L2(SEQ.ID.59,SEQ.ID.60)、ETS1(SEQ.ID.61,SEQ.ID.62)、HDAC5(SEQ.ID.63,SEQ.ID.64)、HHEX(SEQ.ID.65,SEQ.ID.66)、HOXA5(SEQ.ID.67,SEQ.ID.68)、ID3(SEQ.ID.69,SEQ.ID.70)、IKZF1(SEQ.ID.71,SEQ.ID.72)、IKZF2(SEQ.ID.73,SEQ.ID.74)、IKZF3(SEQ.ID.75,SEQ.ID.76)、IKZF5(SEQ.ID.77,SEQ.ID.78)、IRF7(SEQ.ID.79,SEQ.ID.80)、MEF2C(SEQ.ID.81,SEQ.ID.82)、MYB(SEQ.ID.83,SEQ.ID.84)、RUNX2(SEQ.ID.85,SEQ.ID.86)、STAT3(SEQ.ID.87,SEQ.ID.88)、TCF4(SEQ.ID.89,SEQ.ID.90)、TCF12(SEQ.ID.91,SEQ.ID.92)、STAT1(SEQ.ID.93,SEQ.ID.94)和TSC22D1(SEQ.ID.95,SEQ.ID.96)。
在一个实施方案中，本公开内容的转录因子可以用在兽医或人医学中，特别是在感染性疾病或病毒性疾病或病毒诱导的疾病中，或在癌症或自身免疫性疾病或神经变性疾病中。
在一个实施方案中，为了更好的结果，所述细胞可以选自：多能干细胞、多潜能干细胞、造血干细胞、分化的细胞、肿瘤细胞、癌细胞、细胞系，特别是中胚层衍生的细胞系，诸如单核细胞细胞系，及其混合物。特别是哺乳动物细胞，更特别是小鼠或人细胞。
在一个实施方案中，为了更好的结果，本公开内容的转录因子可以用作选自多能干细胞或多潜能干细胞或分化的细胞、及其混合物的细胞向树突细胞或I型干扰素产生细胞或抗原呈递细胞、优选树突细胞或I型干扰素产生细胞的重新程序化或诱导因子。
在一个实施方案中，为了更好的结果，本公开内容的转录因子可以用作选自多能干细胞、多潜能干细胞或分化的细胞、及其混合物的细胞向树突细胞或I型干扰素产生细胞的重新程序化或诱导因子。
在一个实施方案中，为了更好的结果，本公开内容的转录因子可以用作选自肿瘤细胞、癌细胞、及其混合物的细胞向抗原呈递细胞的重新程序化或诱导因子。
在一个实施方案中，本公开内容的结果显示，在Clec9a报告小鼠中，将pDC用tdTomato荧光蛋白标记，使得该模型适合于筛选pDC诱导因子。IRF8已被描述为对cDC1和pDC规范发挥关键作用，并在两个DC子集上高度表达。因此，本发明将IRF8与单独的24种候选者中的每一种组合，并在Clec9a报告小鼠胚胎成纤维细胞(MEF)中进行渐进加性筛选。
在一个实施方案中，令人惊讶的是，与SPIB组合的IRF8足以诱导报告物活化。此外，当将IRF8和SPIB与BCL11A、CBFA2T3、CREB3L2、ETS1、STAT1、TCF4、TCF12或TSC22D1组合时，报告物活化的效率令人惊讶地增加。对DC功能而言重要的主要组织相容性复合物(MHC)II类分子的表达也由基于IRF8和IRF8+SPIB的pDC诱导TF的组合诱导。
在一个实施方案中，IRF8和SPIB的表达足以诱导造血标志物CD45的表面表达。值得注意的是，当将IRF8和SPIB与IKZF1或IKZF2组合时，CD45的表面表达令人惊讶地增加。
在一个实施方案中，在用TLR7和TLR9配体刺激后，IRF8和SPIB能够诱导分泌I型干扰素(即IFN-α和IFN-β)的能力，而不诱导分泌抗炎性IL-10的能力，这是pDC特有的表型特性。当将IRF8和SPIB与BCL11A、CBFA2T3、CREB3L2、ETS1、STAT1、TCF4、TCF12或TSC22D1组合时，干扰素分泌进一步增加。用PU.1、IRF8和BATF3 TF生成的诱导的DC没有显示分泌I型干扰素的能力。
在一个实施方案中，在用TLR7和TLR9配体刺激后，IRF8和SPIB能够诱导分泌促炎细胞因子、特别是IL-6和TNF-α的能力，这是pDC特有的表型特性。当将IRF8和SPIB与ETS1、STAT1、TCF12或TSC22D1组合时，细胞因子分泌会进一步增加。
在一个实施方案中，在用TLR7和TLR9配体刺激后，IRF8和SPIB能够诱导分泌趋化因子即CCL5和CXCL10的能力，这是pDC特有的表型特性。当将IRF8和SPIB与HOXA5、STAT1、TCF12或TSC22D1组合时，趋化因子分泌进一步增加。
本发明主题的一个方面涉及一种组合物，其包含至少两种转录因子的组合，所述转录因子由分离的或合成的序列编码，所述序列与来自由转录因子组成的列表的序列具有至少90％同一性，所述转录因子选自由以下成员组成的列表：IRF8(SEQ.ID.1,SEQ.ID.2)、SPIB(SEQ.ID.3,SEQ.ID.4)、ARID5A(SEQ.ID.5,SEQ.ID.6)、BCL11A(SEQ.ID.7,SEQ.ID.8)、CBFA2T3(SEQ.ID.9,SEQ.ID.10)、CREB3L2(SEQ.ID.11,SEQ.ID.12)、ETS1(SEQ.ID.13,SEQ.ID.14)、IKZF1(SEQ.ID.23,SEQ.ID.24)、STAT1(SEQ.ID.45,SEQ.ID.46)、TCF4(SEQ.ID.41,SEQ.ID.42)、TCF12(SEQ.ID.43,SEQ.ID.44)、TSC22D1(SEQ.ID.47,SEQ.ID.48)、及其混合物；
所述组合物用于在受试者中将干细胞或分化的细胞或其混合物重新程序化成浆细胞样树突细胞或干扰素产生细胞或抗原呈递细胞，优选浆细胞样树突细胞或I型干扰素产生细胞。
本发明主题的一个方面涉及包含至少两种转录因子IRF8和SPIB的组合物，所述组合物用于在受试者中将干细胞或分化的细胞或其混合物重新程序化成浆细胞样树突细胞或I型干扰素产生细胞。
在一个实施方案中，本公开内容的组合物包含如本文所述的至少两种转录因子，前提条件是，至少两种转录因子(其可以是分离的或合成的转录因子)的组合不是TCF4(SEQ.ID.41,SEQ.ID.42)和IRF8(SEQ.ID.1,SEQ.ID.2)。
在一个实施方案中，本公开内容的组合物进一步包含一种或多种选自以下的转录因子：ARID5A、BCL11A、CBFA2T3、CREB3L2、ETS1、IKZF1、STAT1、TCF4、TCF12和TSC22D1，优选BCL11A、CBFA2T3、CREB3L2、ETS1、IKZF1、TCF4、TCF12和TSC22D1。
在一个实施方案中，本公开内容的组合物可以包含至少两种转录因子的组合，所述转录因子由分离的或合成的序列编码，所述序列与来自选定的TF的序列具有至少95％同一性，优选96％、97％、98％、99％或同一性，所述选定的TF选自：IRF8(SEQ.ID.1,SEQ.ID.2)、SPIB(SEQ.ID.3,SEQ.ID.4)、ARID5A(SEQ.ID.5,SEQ.ID.6)、BCL11A(SEQ.ID.7,SEQ.ID.8)、CBFA2T3(SEQ.ID.9,SEQ.ID.10)、CREB3L2(SEQ.ID.11,SEQ.ID.12)、ETS1(SEQ.ID.13,SEQ.ID.14)、IKZF1(SEQ.ID.23,SEQ.ID.24)、STAT1(SEQ.ID.45,SEQ.ID.46)、TCF4(SEQ.ID.41,SEQ.ID.42)、TCF12(SEQ.ID.43,SEQ.ID.44)、TSC22D1(SEQ.ID.47,SEQ.ID.48)、及其混合物。
在本公开内容的一个实施方案中，所述转录因子与选自以下的序列具有至少90％同一性，优选91％、92％、93％、94％、95％、96％、97％、98％、99％或同一性：IRF8(SEQ.ID.1,SEQ.ID.2)、SPIB(SEQ.ID.3,SEQ.ID.4)、ARID5A(SEQ.ID.5,SEQ.ID.6)、BCL11A(SEQ.ID.7,SEQ.ID.8)、CBFA2T3(SEQ.ID.9,SEQ.ID.10)、CREB3L2(SEQ.ID.11,SEQ.ID.12)、ETS1(SEQ.ID.13,SEQ.ID.14)、IKZF1(SEQ.ID.23,SEQ.ID.24)、STAT1(SEQ.ID.45,SEQ.ID.46)、TCF4(SEQ.ID.41,SEQ.ID.42)、TCF12(SEQ.ID.X,SEQ.ID.X)、TSC22D1(SEQ.ID.47,SEQ.ID.48)、及其混合物。
在一个实施方案中，本公开内容的组合物可以包含选自以下组合的转录因子的组合：
IRF8(SEQ.ID.1,SEQ.ID.2)和SPIB(SEQ.ID.3,SEQ.ID.4)；
IRF8(SEQ.ID.1,SEQ.ID.2)、SPIB(SEQ.ID.3,SEQ.ID.4)和ARID5A(SEQ.ID.5,SEQ.ID.6)；
IRF8(SEQ.ID.1,SEQ.ID.2)、SPIB(SEQ.ID.5,SEQ.ID.6)和BCL11A(SEQ.ID.7,SEQ.ID.8)；
IRF8(SEQ.ID.1,SEQ.ID.2)、SPIB(SEQ.ID.3,SEQ.ID.4)和CBFA2T3(SEQ.ID.9,SEQ.ID.10)；
IRF8(SEQ.ID.1,SEQ.ID.2)、SPIB(SEQ.ID.3,SEQ.ID.4)和CREB3L2(SEQ.ID.11,SEQ.ID.12)；
IRF8(SEQ.ID.1,SEQ.ID.2)、SPIB(SEQ.ID.3,SEQ.ID.4)和ETS1(SEQ.ID.13,SEQ.ID.14)；
IRF8(SEQ.ID.1,SEQ.ID.2)、SPIB(SEQ.ID.3,SEQ.ID.4)和IKZF1(SEQ.ID.23,SEQ.ID.24)；
IRF8(SEQ.ID.1,SEQ.ID.2)、SPIB(SEQ.ID.3,SEQ.ID.4)和STAT1(SEQ.ID.45,SEQ.ID.46)；
IRF8(SEQ.ID.1,SEQ.ID.2)、SPIB(SEQ.ID.3,SEQ.ID.4)和TCF4(SEQ.ID.41,SEQ.ID.42)；
IRF8(SEQ.ID.1,SEQ.ID.2)、SPIB(SEQ.ID.3,SEQ.ID.4)和TCF12(SEQ.ID.43,SEQ.ID.44)；
IRF8(SEQ.ID.1,SEQ.ID.2)、SPIB(SEQ.ID.3,SEQ.ID.4)和TSC22D1(SEQ.ID.47,SEQ.ID.48)，及其混合物。
在一个实施方案中，本公开内容的组合物可以包含选自以下组合的转录因子的组合：
IRF8和SPIB；
IRF8、SPIB和ARID5A；
IRF8、SPIB和BCL11A；
IRF8、SPIB和CBFA2T3；
IRF8、SPIB和CREB3L2；
IRF8、SPIB和ETS1；
IRF8、SPIB和IKZF1；
IRF8、SPIB和STAT1；
IRF8、SPIB和TCF4；
IRF8、SPIB和TCF12；
IRF8、SPIB和TSC22D1；及其混合物。
在一个实施方案中，本公开内容的组合物可以包含转录因子的组合，其中所述组合是IRF8(SEQ.ID.1,SEQ.ID.2)和SPIB(SEQ.ID.3,SEQ.ID.4)，或IRF8(SEQ.ID.1,SEQ.ID.2)、SPIB(SEQ.ID.3,SEQ.ID.4)和TCF12(SEQ.ID.43,SEQ.ID.44)。
在一个实施方案中，本公开内容的组合物可以包含转录因子的组合，其中所述组合是IRF8、SPIB和TCF12。
在一个实施方案中，本公开内容的组合物可以包含转录因子的组合，其中所述组合是IRF8、SPIB和TSC22D1。
在一个实施方案中，本公开内容的组合物可以包含多能干细胞或多潜能干细胞、分化的细胞、及其混合物。
在一个实施方案中，本公开内容的组合物可以用作选自肿瘤细胞、癌细胞、及其混合物的细胞向I型干扰素产生细胞的重新程序化或诱导因子。
在一个实施方案中，本公开内容的组合物可以用作pDC的重新程序化或诱导因子，其中所述抗原是：癌症抗原、自体抗原、变应原、来自病原性和/或感染性生物体的抗原。
在一个实施方案中，通过使用本公开内容的转录因子的组合所得到的细胞具有对TLR7和TLR9刺激做出应答的能力，和/或所述细胞具有分泌I型干扰素细胞因子即IFN-α和IFN-β的能力。
本公开内容的另一个方面涉及本公开内容的组合物在兽医或人医学中的用途，特别是在免疫疗法中的用途，或在神经变性或老化疾病中的用途，或在癌症中的用途，或在感染性疾病中的用途，或作为药物筛选的用途。
本公开内容的另一个方面涉及本公开内容的组合物在癌症的诊断、疗法或治疗、抗病毒免疫应答和免疫病理学中的用途，特别是在自身免疫性疾病和免疫缺陷病况中的用途。
在一个实施方案中，所述多能干细胞、多潜能干细胞或分化的细胞是哺乳动物多能干细胞、多潜能干细胞或分化的细胞，特别是小鼠或人细胞。
在一个实施方案中，本公开内容的组合物可以用在感染性疾病、病毒性疾病或病毒诱导的疾病的治疗、疗法或诊断中。
在一个实施方案中，本公开内容的组合物可以用作抗病毒剂或免疫原性组合物。
本公开内容的另一个方面涉及一种构建体或载体，其编码在本公开内容中描述的至少两种分离的转录因子的组合，优选编码三种转录因子的组合，更优选四种转录因子的组合。
在一个实施方案中，至少两种分离的转录因子的组合从5’至3’具有以下序列顺序：
SPIB(SEQ.ID.3,SEQ.ID.4)和IRF8(SEQ.ID.1,SEQ.ID.2)；
IRF8(SEQ.ID.1,SEQ.ID.2)和SPIB(SEQ.ID.3,SEQ.ID.4)；
SPIB(SEQ.ID.3,SEQ.ID.4)、IRF8(SEQ.ID.1,SEQ.ID.2)和ARID5A(SEQ.ID.5,SEQ.ID.6)；
SPIB(SEQ.ID.5,SEQ.ID.6)、IRF8(SEQ.ID.1,SEQ.ID.2)和BCL11A(SEQ.ID.7,SEQ.ID.8)；
SPIB(SEQ.ID.3,SEQ.ID.4)、IRF8(SEQ.ID.1,SEQ.ID.2)和CBFA2T3(SEQ.ID.9,SEQ.ID.10)；
SPIB(SEQ.ID.3,SEQ.ID.4)、IRF8(SEQ.ID.1,SEQ.ID.2)和CREB3L2(SEQ.ID.11,SEQ.ID.12)；
SPIB(SEQ.ID.3,SEQ.ID.4)、IRF8(SEQ.ID.1,SEQ.ID.2)和ETS1(SEQ.ID.13,SEQ.ID.14)；
SPIB(SEQ.ID.3,SEQ.ID.4)、IRF8(SEQ.ID.1,SEQ.ID.2)和IKZF1(SEQ.ID.23,SEQ.ID.24)；
SPIB(SEQ.ID.3,SEQ.ID.4)、IRF8(SEQ.ID.1,SEQ.ID.2)和STAT1(SEQ.ID.45,SEQ.ID.46)；
SPIB(SEQ.ID.3,SEQ.ID.4)、IRF8(SEQ.ID.1,SEQ.ID.2)和TCF4(SEQ.ID.41,SEQ.ID.42)；
SPIB(SEQ.ID.3,SEQ.ID.4)、IRF8(SEQ.ID.1,SEQ.ID.2)和TCF12(SEQ.ID.43,SEQ.ID.44)；
SPIB(SEQ.ID.3,SEQ.ID.4)、IRF8(SEQ.ID.1,SEQ.ID.2)和TSC22D1(SEQ.ID.47,SEQ.ID.48)。
本公开内容的另一个方面涉及一种构建体或载体，其编码在本公开内容中描述的至少两种分离的转录因子的组合，优选编码三种转录因子的组合，其中所述至少两种分离的转录因子的组合从5’至3’具有以下序列顺序：
SPIB(SEQ.ID.3,SEQ.ID.4)和IRF8(SEQ.ID.1,SEQ.ID.2)；
IRF8(SEQ.ID.1,SEQ.ID.2)和SPIB(SEQ.ID.3,SEQ.ID.4)；
SPIB(SEQ.ID.3,SEQ.ID.4)、IRF8(SEQ.ID.1,SEQ.ID.2)和ARID5A(SEQ.ID.5,SEQ.ID.6)；
SPIB(SEQ.ID.5,SEQ.ID.6)、IRF8(SEQ.ID.1,SEQ.ID.2)和BCL11A(SEQ.ID.7,SEQ.ID.8)；
SPIB(SEQ.ID.3,SEQ.ID.4)、IRF8(SEQ.ID.1,SEQ.ID.2)和CBFA2T3(SEQ.ID.9,SEQ.ID.10)；
SPIB(SEQ.ID.3,SEQ.ID.4)、IRF8(SEQ.ID.1,SEQ.ID.2)和CREB3L2(SEQ.ID.11,SEQ.ID.12)；
SPIB(SEQ.ID.3,SEQ.ID.4)、IRF8(SEQ.ID.1,SEQ.ID.2)和ETS1(SEQ.ID.13,SEQ.ID.14)；
SPIB(SEQ.ID.3,SEQ.ID.4)、IRF8(SEQ.ID.1,SEQ.ID.2)和IKZF1(SED.ID.23,SEQ.ID.24)；
SPIB(SEQ.ID.3,SEQ.ID.4)、IRF8(SEQ.ID.1,SEQ.ID.2)和STAT1(SEQ.ID.45,SEQ.ID.46)；
SPIB(SEQ.ID.3,SEQ.ID.4)、IRF8(SEQ.ID.1,SEQ.ID.2)和TCF4(SEQ.ID.41,SEQ.ID.42)；
SPIB(SEQ.ID.3,SEQ.ID.4)、IRF8(SEQ.ID.1,SEQ.ID.2)和TCF12(SEQ.ID.43,SEQ.ID.44)；
SPIB(SEQ.ID.3,SEQ.ID.4)、IRF8(SEQ.ID.1,SEQ.ID.2)和TSC22D1(SEQ.ID.47,SEQ.ID.48)。
在一个实施方案中，所述载体是病毒载体；特别是逆转录病毒、腺病毒、慢病毒、疱疹病毒、痘病毒、副粘病毒、棒状病毒、甲病毒、黄病毒或腺相关病毒载体。
在一个实施方案中，所述载体或构建体是合成的mRNA、裸甲病毒RNA复制子或裸黄病毒RNA复制子。
在本公开内容的一个方面，一种或多种载体包含编码至少两种转录因子IRF和SPIB的至少两种多核苷酸序列，其用于在受试者中将干细胞或分化的细胞或其混合物重新程序化成浆细胞样树突细胞或I型干扰素产生细胞。
在本公开内容的一个实施方案中，所述一种或多种载体进一步编码一种或多种选自以下的转录因子：ARID5A、BCL11A、CBFA2T3、CREB3L2、ETS1、IKZF1、STAT1、TCF4、TCF12和TSC22D1，优选BCL11A、CBFA2T3、CREB3L2、ETS1、IKZF1、TCF4、TCF12和TSC22D1。
在本公开内容的一个实施方案中，一种或多种载体的转录因子各自与选自以下的序列具有至少90％同一性：IRF8(SEQ.ID.49,SEQ.ID.50)、SPIB(SEQ.ID.51,SEQ.ID.52)、ARID5A(SEQ.ID.53,SEQ.ID.54)、BCL11A(SEQ.ID.55,SEQ.ID.56)、CBFA2T3(SEQ.ID.57,SEQ.ID.58)、CREB3L2(SEQ.ID.59,SEQ.ID.60)、ETS1(SEQ.ID.61,SEQ.ID.62)、IKZF1(SEQ.ID.71,SEQ.ID.72)、TCF4(SEQ.ID.89,SEQ.ID.90)、TCF12(SEQ.ID.91,SEQ.ID.92)、STAT1(SEQ.ID.93,SEQ.ID.94)和TSC22D1(SEQ.ID.95,SEQ.ID.96)。
在本公开内容的一个实施方案中，所述一种或多种载体的转录因子的组合选自以下组合：
IRF8和SPIB；
IRF8、SPIB和ARID5A；
IRF8、SPIB和BCL11A；
IRF8、SPIB和CBFA2T3；
IRF8、SPIB和CREB3L2；
IRF8、SPIB和ETS1；
IRF8、SPIB和IKZF1；
IRF8、SPIB和STAT1；
IRF8、SPIB和TCF4；
IRF8、SPIB和TCF12；和
IRF8、SPIB和TSC22D1。
在本公开内容的一个实施方案中，所述一种或多种载体的转录因子的组合是IRF8、SPIB和TCF12的组合。
在本公开内容的一个实施方案中，所述一种或多种载体的转录因子的组合是IRF8、SPIB和TSC22D1的组合。
在本公开内容的一个实施方案中，用于使用一种或多种载体进行重新程序化的细胞选自：多能干细胞、多潜能干细胞、分化的细胞、肿瘤细胞、癌症细胞及其混合物。
在本公开内容的一个实施方案中，所述一种或多种载体用在兽医或人医学中，特别是在抗病毒免疫应答和免疫病理学的诊断、疗法或治疗中，尤其是自身免疫性疾病和免疫缺陷病况、瘤形成、特别是癌症(即实体或血液学肿瘤)、良性肿瘤、恶性肿瘤、早期癌症、基底细胞癌、宫颈发育不良、软组织肉瘤、生殖细胞肿瘤、视网膜母细胞瘤、年龄相关性黄斑变性、霍奇金淋巴瘤、血癌、前列腺癌、卵巢癌、子宫颈癌、子宫癌、阴道癌、乳腺癌、鼻咽癌、气管癌、喉癌、支气管癌、细支气管癌、肺癌、中空器官癌、食管癌、胃癌、胆管癌、肠癌、结肠癌、结肠直肠癌、直肠癌、膀胱癌、输尿管癌、肾癌、肝癌、胆囊癌、脾癌、脑癌、淋巴系统癌症、骨癌、胰腺癌、白血病、皮肤癌或骨髓瘤、感染性疾病、病毒性疾病或病毒诱导的疾病、中枢和周围神经系统病症、真菌性、病毒性、衣原体性、细菌性、纳米细菌性或寄生性感染性疾病或病毒性疾病或病毒诱导的疾病的诊断、疗法或治疗中，用作抗病毒剂或用作免疫原性组合物，免疫疗法，或在神经变性疾病的治疗或疗法中，在癌症的治疗或疗法中，或在感染性疾病的治疗或疗法中，真皮内和透皮疗法中，HIV、SARS冠状病毒感染、亚洲流感病毒、单纯疱疹、流感病毒、带状疱疹、肝炎、人乳头瘤病毒、爱泼斯坦-巴尔病毒、人嗜T淋巴细胞病毒或病毒性肝炎、淀粉样蛋白疾病、尤其是淀粉样蛋白A淀粉样变性、阿尔茨海默氏病、轻链(AL)淀粉样变性、2型糖尿病、甲状腺管道样癌、帕金森病、多神经病或海绵状脑病-Creutzfeldt Jakob疾病的治疗或疗法中，或用于药物筛选。
本公开内容的另一个方面涉及一种用于将细胞重新程序化或诱导成浆细胞样树突细胞或I型干扰素产生细胞的方法，所述方法包括下述步骤：
用一种或多种载体转导选自干细胞或分化的细胞、及其混合物的细胞，所述载体包含至少两种核酸序列，所述核酸序列编码与选自以下的序列具有至少90％同一性、优选至少95％同一性的序列：IRF8(SEQ.ID.1,SEQ.ID.2)、SPIB(SEQ.ID.3,SEQ.ID.4)、ARID5A(SEQ.ID.5,SEQ.ID.6)、BCL11A(SEQ.ID.7,SEQ.ID.8)、CBFA2T3(SEQ.ID.9,SEQ.ID.10)、CREB3L2(SEQ.ID.11,SEQ.ID.12)、ETS1(SEQ.ID.13,SEQ.ID.14)、IKZF1(SEQ.ID.23,SEQ.ID.24)、TCF4(SEQ.ID.41,SEQ.ID.42)、TCF12(SEQ.ID.43,SEQ.ID.44)、STAT1(SEQ.ID.45,SEQ.ID.46)、TSC22D1(SEQ.ID.47,SEQ.ID.48)、及其混合物；
在细胞培养基中培养转导的细胞，所述细胞培养基支持浆细胞样树突细胞或I型干扰素产生细胞的生长。
本公开内容的另一个方面涉及用于将细胞重新程序化或诱导成浆细胞样树突细胞或I型干扰素产生细胞的体外方法，所述方法包括下述步骤：
用一种或多种载体转导选自干细胞或分化的细胞、及其混合物的细胞，所述载体包含至少两种转录因子IRF8和SPIB，
在细胞培养基中培养转导的细胞，所述细胞培养基支持浆细胞样树突细胞或I型干扰素产生细胞的生长。
在一个实施方案中，所述序列选自以下组合
IRF8(SEQ.ID.1,SEQ.ID.2)和SPIB(SEQ.ID.3,SEQ.ID.4)；
IRF8(SEQ.ID.1,SEQ.ID.2)、SPIB(SEQ.ID.3,SEQ.ID.4)和ARID5A(SEQ.ID.5,SEQ.ID.6)；
IRF8(SEQ.ID.1,SEQ.ID.2)、SPIB(SEQ.ID.5,SEQ.ID.6)和BCL11A(SEQ.ID.7,SEQ.ID.8)；
IRF8(SEQ.ID.1,SEQ.ID.2)、SPIB(SEQ.ID.3,SEQ.ID.4)和CBFA2T3(SEQ.ID.9,SEQ.ID.10)；
IRF8(SEQ.ID.1,SEQ.ID.2)、SPIB(SEQ.ID.3,SEQ.ID.4)和CREB3L2(SEQ.ID.11,SEQ.ID.12)；
IRF8(SEQ.ID.1,SEQ.ID.2)、SPIB(SEQ.ID.3,SEQ.ID.4)和ETS1(SEQ.ID.13,SEQ.ID.14)；
IRF8(SEQ.ID.1,SEQ.ID.2,SPIB(SEQ.ID.3,SEQ.ID.4)和IKZF1(SEQ.ID.23,SEQ.ID.24)；
IRF8(SEQ.ID.1,SEQ.ID.2,SPIB(SEQ.ID.3,SEQ.ID.4)和STAT1(SEQ.ID.45,SEQ.ID.46)；
IRF8(SEQ.ID.1,SEQ.ID.2)、SPIB(SEQ.ID.3,SEQ.ID.4)和TCF4(SEQ.ID.41,SEQ.ID.42)；
IRF8(SEQ.ID.1,SEQ.ID.2)、SPIB(SEQ.ID.3,SEQ.ID.4)和TCF12(SEQ.ID.43,SEQ.ID.44)；
IRF8(SEQ.ID.1,SEQ.ID.2)、SPIB(SEQ.ID.3,SEQ.ID.4)和TSC22D1(SEQ.ID.47,SEQ.ID.48)，及其混合物。
在一个实施方案中，所述序列选自以下组合：
IRF8和SPIB；
IRF8、SPIB和ARID5A；
IRF8、SPIB和BCL11A；
IRF8、SPIB和CBFA2T3；
IRF8、SPIB和CREB3L2；
IRF8、SPIB和ETS1；
IRF8、SPIB和IKZF1；
IRF8、SPIB和STAT1；
IRF8、SPIB和TCF4；
IRF8、SPIB和TCF12；
IRF8、SPIB和TSC22D1，及其混合物。
在一个实施方案中，所述方法可以包括将转导的细胞培养至少2天、优选至少5天、更优选至少8天、甚至更优选至少9天的步骤。
在一个实施方案中，所述转导步骤进一步包含至少一种载体，其选自：编码IL-12的核酸序列；编码IL-4的核酸序列；编码IFN-α的核酸序列；编码IFN-β的核酸序列；编码IFN-γ的核酸序列；编码TNF的核酸序列；编码GM-CSF的核酸序列；编码靶向IL-10RNA的siRNA的核酸序列，及其混合物。
在一个实施方案中，所述转导步骤进一步包含至少一种载体，所述载体包含编码免疫刺激性细胞因子的核酸。
在一个实施方案中，所述细胞选自：多能干细胞、多潜能干细胞或分化的细胞、及其混合物；特别是哺乳动物细胞。
在一个实施方案中，所述多能干细胞、多潜能干细胞或分化的细胞选自：内胚层衍生的细胞、中胚层衍生的细胞、外胚层衍生的细胞、多潜能干细胞，包括间质干细胞、造血干细胞、肠干细胞、多能干细胞和细胞系。
在一个实施方案中，所述细胞是人的或非人的。在另一个实施方案中，所述细胞是小鼠细胞。
本公开内容的另一个方面涉及通过在本公开内容中描述的体外方法得到的诱导的浆细胞样树突细胞或I型干扰素产生细胞或抗原呈递细胞，优选诱导的浆细胞样树突细胞或I型干扰素产生细胞。
本公开内容的另一个方面涉及一种组合物，其包含治疗有效量的在本公开内容中描述的浆细胞样树突细胞或I型干扰素产生细胞或抗原呈递细胞，优选诱导的浆细胞样树突细胞或I型干扰素产生细胞，和药学上可接受的赋形剂。
在一个实施方案中，所述组合物可以用在兽医或人医学中。
在一个实施方案中，所述组合物可以用在免疫疗法中，或在神经变性疾病的治疗或疗法中，或在癌症的治疗或疗法中，或在感染性疾病的治疗或疗法中。
在一个实施方案中，所述组合物可以进一步包含镇痛剂、抗炎剂、化疗剂、放疗剂、抗生素、利尿剂或其混合物。
在一个实施方案中，所述组合物可以进一步包含填充剂、粘合剂、崩解剂或润滑剂或其混合物。
在一个实施方案中，所述组合物可以用在真皮内和透皮疗法中。
在一个实施方案中，所述组合物可以用在可注射制剂、优选原位注射剂中。
在一个实施方案中，所述组合物可以用在兽医或人医学中，或在药物筛选中。
在一个实施方案中，所述组合物可以用在中枢和周围神经系统病症的治疗、疗法或诊断中。
在一个实施方案中，所述组合物可以用在瘤形成、特别是癌症诸如实体或血液学肿瘤的治疗、疗法或诊断中。
在一个实施方案中，所述组合物、载体或构建体可以用在良性肿瘤、恶性肿瘤、早期癌症、基底细胞癌、宫颈发育不良、软组织肉瘤、生殖细胞肿瘤、视网膜母细胞瘤、年龄相关性黄斑变性、霍奇金淋巴瘤、血癌、前列腺癌、卵巢癌、子宫颈癌、子宫癌、阴道癌、乳腺癌、鼻咽癌、气管癌、喉癌、支气管癌、细支气管癌、肺癌、中空器官癌、食管癌、胃癌、胆管癌、肠癌、结肠癌、结肠直肠癌、直肠癌、膀胱癌、输尿管癌、肾癌、肝癌、胆囊癌、脾癌、脑癌、淋巴系统癌症、骨癌、胰腺癌、白血病、皮肤癌或骨髓瘤的治疗、诊断或疗法中。
在一个实施方案中，所述组合物、载体或构建体可以用在真菌性、病毒性、衣原体性、细菌性、纳米细菌性或寄生性感染性疾病或病毒性疾病或病毒诱导的疾病的治疗、疗法或诊断中。
在一个实施方案中，所述组合物、载体或构建体可以用在HIV、SARS冠状病毒感染、亚洲流感病毒、单纯疱疹、流感病毒、带状疱疹、肝炎、人乳头瘤病毒、爱泼斯坦-巴尔病毒、人嗜T淋巴细胞病毒或病毒性肝炎的治疗、疗法或诊断中。
在一个实施方案中，所述组合物、载体或构建体可以用在淀粉样蛋白疾病、尤其是淀粉样蛋白A淀粉样变性、阿尔茨海默氏病、轻链(AL)淀粉样变性、2型糖尿病、甲状腺管道样癌、帕金森病、多神经病或海绵状脑病诸如Creutzfeldt Jakob疾病的治疗、疗法或诊断中。
本公开内容的另一个方面涉及疫苗或可注射制剂，其包含在本公开内容中描述的组合物、载体或构建体，和/或在本公开内容中描述的诱导的浆细胞样树突细胞或I型干扰素产生细胞，或所描述的抗原呈递细胞，或其混合物。
本公开内容的另一个方面涉及一种试剂盒，其包含下述组分中的至少一种：
本公开内容的诱导的浆细胞样树突细胞或I型干扰素产生细胞或抗原呈递细胞；
在本公开内容中描述的组合物；
在本公开内容中描述的一种或多种载体或构建体；或其混合物。
本公开内容的另一个方面涉及一种试剂盒，其包含下述组分中的至少一种：
本公开内容的诱导的浆细胞样树突细胞或I型干扰素产生细胞；
在本公开内容中描述的组合物；
在本公开内容中描述的一种或多种载体或构建体；或其混合物。
在一个实施方案中，本公开内容提供了当与SPIB组合时IRF8在成纤维细胞中启动pDC程序的证据。这些发现为pDC规范提供了有价值的见解。未来，通过直接重新程序化来产生pDC开辟了用自体工程改造的细胞诱导抗病毒免疫应答的途径。
附图描述
以下附图提供了用于说明本公开内容的优选实施方案并且不应被视为限制本发明的范围。
图1.树突细胞的主要子集的个体发育。虽然常规树突细胞1型(cDC1)和2型(cDC2)来自于源自常见树突细胞祖细胞(CDP)的前-DC群体，但浆细胞样树突细胞(pDC)可以源自常见淋巴细胞祖细胞(CLP)或CDP。pDC作为独特的DC子集出现，该子集在病毒感染后专门产生I型干扰素(IFN)。cDC1在执行交叉呈递、诱导细胞毒性T细胞应答和优先极化T辅助细胞1应答的能力方面表现出色。cDC2在将抗原呈递给T辅助细胞、从而极化T辅助细胞2或17应答方面表现出色。
图2.通过直接细胞重新程序化产生pDC或I型干扰素(IFN)产生细胞。观察本发明主题中公开的转录因子(TF)组合对从多能干细胞、多潜能干细胞和体细胞(诸如成纤维细胞)诱导pDC的效果。pDC专门生产I型IFN，并因此将应用于个性化免疫疗法的背景下。诱导的pDC或诱导pDC的TF组合将用于在不同的患病背景(包括病毒感染和癌症)下诱导免疫。
图3.Clec9a、Irf8、Tlr7和Tlr9的表达限于pDC。显示Clec9a、Irf8、Tlr7和Tlr9在pDC和个体发育接近的其它免疫细胞(特别是cDC1和cDC2、巨噬细胞和单核细胞)中的表达水平的热图。从免疫基因组计划(Immunological Genome Project)(www.immgen.com)中可用的数据获得表达概况。
图4.诱导pDC的TF候选物。与cDC1和cDC2相比，22种候选TF在pDC中高度富集。显示从免疫基因组计划中可用数据中提取的基因表达概况的热图。
图5.Clec9a在pDC中表达。tdTomato在92％的从双转基因Clec9a-Cre x Rosa26-停止-tdTomato的脾中分离的pDC(门控为CD11c低BST2+B220+Siglec-H+细胞)上的表达。
图6.与SPIB组合的IRF8诱导Clec9a报告物活化。将从双转基因Clec9a-tdTomato小鼠分离的小鼠胚胎成纤维细胞(MEF)用诱导型慢病毒载体的合并物转导，所述慢病毒载体编码单独的IRF8或与另外pDC诱导TF组合的IRF8，并在添加Dox后5天通过流式细胞计量术进行分析。用单独的IRF8或与单一pDC诱导候选TF组合的IRF8转导后tdTomato+细胞的定量。包括M2rtTA转导的细胞作为对照。
图7.诱导的pDC在细胞表面表达抗原呈递分子。在第8天在IRF8和SPIB过表达后产生的tdTomato+细胞的主要组织相容性复合物II类(MHC-II)表达的流式细胞计量术分析。
图8.另外pDC诱导TF与IRF8和SPIB的组合增加了Clec9a报告物活化的效率。用单独的IRF8和SPIB或与各个pDC诱导因子组合的IRF8和SPIB转导双转基因Clec9a-tdTomatoMEF后tdTomato+细胞的定量。在第8天进行流式细胞计量术分析。包括M2rtTa转导的细胞作为对照。
图9.另外pDC诱导TF与IRF8和SPIB的组合增加了MHC-II在细胞表面的表达。在第8天，用M2rtTA、单独的IRF8+SPIB或与各个pDC诱导因子组合的IRF8+SPIB转导的MEF的MHC-II表达的流式细胞计量术分析。对于tdTomato阴性(tdT-)和阳性(tdT+)群体，显示了MHC-II水平的定量。
图10.诱导的pDC在TLR7和TLR9刺激后分泌I型干扰素。用M2rtTA、PIB(PU.1、IRF8和BATF3)、单独的IRF8+SPIB或者与ARID5A、BCL11A、CBFA2T3、ETS1、HOXA5、TCF4和TCF12组合的IRF8+SPIB转导MEF，并在添加多西环素后第9天分选tdTomato+细胞。将纯化的tdTomato+细胞与TLR7(R848)和TLR9(CpG ODN 1668)一起温育过夜，并使用细胞计量术珠子阵列对上清液定量IFN-α(A)、IFN-β(B)和IL-10(C)细胞因子分泌。
图11.诱导pDC的另外TF候选物。当与cDC1和cDC2相比时，Stat1(A)和Tsc22d1(B)在pDC中富集。从免疫基因组计划中可用的数据中提取的基因表达概况。
图12.另外pDC诱导TF与IRF8和SPIB的组合增加了Clec9a报告物活化和MHC-II表面表达的效率。用M2rtTA(M2)、单独的IRF8+SPIB或者与STAT1或TSC22D1组合的IRF8+SPIB转导的MEF的(A)Clec9a报告物活化和(B)MHC-II表达的流式细胞计量术分析。在第5天进行流式细胞计量术分析。包括M2rtTa转导的细胞作为对照。
图13.诱导的pDC在TLR7和TLR9刺激后分泌I型干扰素。将MEF用M2rtTA、单独的IRF8+SPIB或者与STAT1和TSC22D1组合的IRF8+SPIB转导，并在添加多西环素后第9天分选tdTomato+细胞。将纯化的tdTomato+细胞与TLR7(R848)和TLR9(CpG ODN 1668)的触发剂一起温育过夜，并使用细胞计量术珠子阵列对上清液定量IFN-α(A)、IFN-β(B)和IL-10(C)细胞因子分泌。
图14.诱导的pDC在细胞表面表达CD45。在第5天，用M2rtTA、PIB(PU.1、IRF8和BATF3)、单独的IRF8+SPIB或与单独pDC诱导TF组合的IRF8+SPIB转导的MEF的CD45表达的流式细胞计量术分析。包括M2rtTa(M2)转导的细胞作为对照。
图15.诱导的pDC在TLR7和TLR9刺激后分泌促炎细胞因子和趋化因子。将MEF用M2rtTA、单独的IRF8+SPIB或与ARID4A、BCL11A、CBFA2T3、ETS1、HOXA5、STAT1、TCF4、TCF12和TSC22D1组合的IRF8+SPIB转导，并在添加多西环素后第9天分选tdTomato+细胞。将纯化的tdTomato+细胞与TLR7(R848)和TLR9(CpG ODN 1668)一起温育过夜，并使用细胞计量术珠子阵列对上清液定量IL-6(A)、TNF-α(B)、CCL5(C)和CXCL10(D)细胞因子分泌。
详细描述
本公开内容涉及用于将细胞重新程序化成pDC或I型干扰素产生细胞的组合物、核酸构建体、载体、方法及其试剂盒。目的是通过引入和表达分离的/合成的转录因子，从分化的、多潜能或多能干细胞产生具有诱导抗病毒和抗肿瘤应答能力的pDC和I型干扰素产生细胞。更具体地，本公开内容提供了用于通过用特定转录因子的组合的惊人使用进行直接细胞重新程序化而得到pDC或I型干扰素产生细胞的方法。
天然DC是接种在所有组织中的骨髓衍生的细胞。DC准备好对环境进行采样并将收集到的信息传输给适应性免疫系统的细胞(T细胞和B细胞)。在抗原吞噬后，DC通过将处理过的抗原(以肽-主要组织相容性复合物(MHC)分子复合物的形式)呈递给淋巴组织中的原初(也就是说，未经历过抗原的)T细胞来启动免疫应答。DC可以分为2个主要子集：浆细胞样DC(pDC)，以及可以进一步细分为cDC 1型(cDC1)和2型(cDC2)的常规或经典DC(cDC)(图1)。pDC的典型特征是圆形形态和低水平MHC-II的表达，所述MHC-II在活化后上调。在活化后，pDC通常过表达共刺激分子和MHC分子，此外还会分泌负责启动和/或增强许多T和B淋巴细胞应答的各种细胞因子和趋化因子，即肿瘤坏死因子(TNF)-α、IFN-α、IFN-β、IL-12、IL-6和趋化因子诸如CCL5和CXCL10。pDC表达高水平的核酸感知toll-样受体(TLR)TLR7和TLR9。TLR7或TLR9刺激允许pDC对病原体衍生的核酸的检测和大量I型干扰素(即IFN-α和IFN-β)的产生。尽管活化的pDC可以活跃地产生细胞因子并执行抗原呈递和交叉呈递，但仍不清楚这些功能特征是由相同的细胞执行还是由不同的功能特化pDC子集执行。通常通过其对主要组织相容性复合物II类分子(MHC-II)、共刺激分子(诸如CD80/86和CD40)和整联蛋白CD11c的高表达以及它们从非淋巴样器官迁移到淋巴样器官并刺激原初T细胞的优异能力来鉴定cDC。DNGR-1(也被称作CLEC9A)是坏死细胞的受体，其有利于小鼠中对死细胞相关抗原的细胞毒性T淋巴细胞应答(CTL)的交叉引发。DNGR-1由小鼠cDC1、cDC2和pDC选择性地高水平表达，负责识别细胞死亡后暴露的细胞内配体。近年来，显示Clec9a的表达允许鉴定定型为常规或浆细胞样DC谱系及其在淋巴组织中的后代的DC前体(CDP)(Schraml等人,2015)。
如本文所述，能够将分化的细胞重新程序化为诱导的pDC的pDC诱导因子的成功鉴定可以以多种方式促进我们对pDC生物学的基本理解。这项工作将提供对pDC最小转录网络的深入洞察。此外，pDC诱导因子的鉴定为理解pDC状态如何建立以及关键调节机制如何实施提供了前所未有的机会。
转录因子(TF)在发育期间所有细胞类型的规范中都发挥着关键作用。使用TF介导的重新程序化的直接重新程序化策略的成功表明，使用这样的因子将多能ES/iPS细胞或多潜能干细胞的分化引导至特定命运是同样似乎合理的。因此，使用本文鉴定的pDC诱导因子，可以实现通过DC富集的TF的表达将ES/iPS细胞定向分化为确定的DC命运。此外，使用本文鉴定的pDC诱导因子，可以实现通过DC富集的TF的表达将多潜能造血干细胞和祖细胞定向分化为确定的DC命运。
通常，使用病毒载体或不使用病毒载体，通过一次或重复的转导或转染，将编码pDC诱导因子的核酸(例如，DNA或RNA或其构建体)引入细胞中，并且基因产物的表达和/或RNA分子的翻译产生在形态学上、在生物化学上和在功能上与pDC相似的细胞，如本文中所述。在用适当的抗原引发后，这些诱导的pDC能够将它们捕获、处理并呈递给免疫系统的效应细胞(巨噬细胞、T-细胞、B-细胞、NK细胞)并分泌I型IFN，从而引发针对病毒感染和癌症的抗原特异性免疫应答(图2)。
本公开内容的一个方面是在癌细胞(原位或离体)中使用TF或使用TF的组合以迫使它们分泌I型IFN、将它们自己的抗原呈递给免疫细胞并分泌在肿瘤微环境内的其它促炎细胞因子和化学引诱物。这种方法代表了一种可行的策略以增加抗癌免疫疗法的临床结果，因为它绕过了癌症逃避机制并增加了肿瘤免疫原性。
当与cDC1和cDC2以及其它相关的单核细胞相比时，浆细胞样DC特异性地表达Tlr7和Tlr9(图3)。TLR7和TRL9受体允许pDC感知病毒DNA并通过分泌I型IFN做出应答。浆细胞样DC、以及cDC1表达Clec9a和Irf8。
在一个实施方案中，选择了22种候选TF，这是由于当与cDC1和cDC2相比时它们在浆细胞样DC中的特异性富集基因表达(图4)。将22种候选TF单独克隆到重新程序化验证的多西环素(Dox)诱导型慢病毒载体中。
在一个实施方案中，为了通过细胞重新程序化筛选pDC诱导TF和pDC诱导TF组合的效果，使用携带DC-特异性报告物(Clec9a-Cre X R26-停止-tdTomato)的小鼠胚胎成纤维细胞(MEF)来筛选pDC诱导TF的活化DC-特异性的Clec9a-tomato报告物的能力(图4)。在Clec9a-tomato报告小鼠中，tdTomato荧光蛋白仅由CDP、前-DC、cDC和pDC表达(Schraml等人,2015)。在培养中的巨噬细胞、其它免疫谱系或单核细胞衍生的DC不表达Clec9a，且因此不会活化报告物或tdTomato蛋白的表达(图3)。分析了从Clec9a报告物小鼠分离的脾细胞，证实92.4％的pDC细胞(在CD11c低BST2+B220+SiglecH+细胞中门控)表达tdTomato荧光蛋白(图5)。
从E13.5胚胎分离出双转基因Clec9a-tdTomato报告物MEF，并将其通过荧光活化的细胞分选(FACS)排除可能已经定型为造血谱系的任何污染性tdTomato+或CD45+细胞。
在一个实施方案中，SPIB和IRF8足以活化Clec9a。
在一个实施方案中，将Clec9a报告物MEF用单独的IRF8或2种与IRF8加上其它21种候选TF之一的组合进行转导，并评价tdTomato表达。在单独使用2种候选TF或IRF8的21种组合转导后，在添加Dox后5天观察到tdTomato+细胞的出现(图6)。IRF8和SPIB的组合产生了5％的tdTomato+细胞，从而提示，IRF8和SPIB是诱导报告物活化所需的最小因子组合。在用对照M2rtTA载体转导后，没有检测到TdTomato+细胞，用单独的IRF8也没有检测到。
在一个实施方案中，抗原呈递细胞标志物MHC-II在大约60％的用IRF8和SPIB转导的MEF中表达(图7)。
在一个实施方案中，评价了与IRF8和SPIB一起表达剩余20种候选TF的影响(图8)。从测试的20种TF观察到，HHEX、ID3、MEF2C和RUNX2对生成的tdTomato+细胞的数目产生负面影响。ARID5A、HDAC5、HOXA5、IKZF1、IKZF2、IKZF3、IKZF5、IRF7、MYB和STAT3的添加没有影响生成的tdTomato+细胞的数目。BCL11A、CBFA2T3、CREB3L2、ETS1、TCF12和TCF4的添加对产生的tdTomato+细胞的数目产生积极影响，从而提高了报告物活化效率。
在一个实施方案中，评价了Clec9a-tdTomato报告物的活化是否反映在MHC-II(抗原呈递机制的一种关键组分)的表面表达中。值得注意的是，观察到在第8天tdTomato+细胞在表面表达MHC-II(图9)。
在一个实施方案中，除了MHC-II表面分子之外，pDC还分泌具有促炎功能的细胞因子，其对于T-细胞应答的发展而言是重要的。这些应答可以通过触发至少11种不同的Toll-样受体(TLR)来启动，从而允许特异性识别不同的保守微生物或病毒结构。在DC隔室内，pDC特异性地对TLR7和TLR9触发做出响应(图3)。研究了当用TLR7(使用瑞喹莫德或R848)和TLR9(使用ODN 1668)刺激攻击时，诱导的pDC是否向培养基分泌细胞因子(图10)。在诱导的pDC的TLR攻击后，当将每种TF组合产生的经刺激的细胞与非刺激细胞进行对比时，观察到用以下TF重新程序化的tdTomato+细胞对IFN-α的分泌的增加：IRF8和SPIB(16.6倍)；IRF8、SPIB和ARID5A(3.9倍)；IRF8、SPIB和BCL11A(14.8倍)；IRF8、SPIB和CBFA2T3(3.5倍)；IRF8、SPIB和ETS1(3.7倍)；IRF8、SPIB和TCF4(3.6倍)；IRF8、SPIB和TCF12(8.3倍)；和IRF8、SPIB和HOXA5(7.7倍)。诱导的pDC的TLR攻击也增加了用以下TF重新程序化的tdTomato+细胞对IFN-β的分泌：IRF8和SPIB(1.5倍)；IRF8、SPIB和ARID5A(2.3倍)；IRF8、SPIB和BCL11A(2.3倍)；IRF8、SPIB和CBFA2T3(1.9倍)；IRF8、SPIB和ETS1(1.6倍)；IRF8、SPIB和TCF4(1.3倍)；IRF8、SPIB和TCF12(1.9倍)；和IRF8、SPIB和HOXA5(2.6倍)。在诱导的pDC的TLR刺激后，没有观察到抗炎细胞因子IL-10的分泌增加。重要的是，用TF的PU.1、IRF8和BATF3(PIB)组合转导后获得的tdTomato+细胞对TLR7和TLR9没有应答，并且不分泌IFN-α和IFN-β。总之，这些数据表明，通过将Clec9a报告物活化与干扰素分泌能力相组合，我们成功地鉴定了能够通过直接细胞重新程序化诱导pDC或I型干扰素分泌细胞的TF组合。
在一个实施方案中，由于与cDC1和cDC2相比它们在浆细胞样DC中特异性富集基因表达，因此选择了两种另外候选TF：STAT1和TSC22D1(图11)。这两种TF分别克隆在相同的重新程序化证明的多西环素(Dox)诱导型慢病毒载体中，并与IRF8和SPIB联合测试以了解它们诱导Clec9a-tdTomato报告物活化的能力(图12)。令人感兴趣的是，与单独的IRF8和SPIB相比，STAT1或TSC22D1向IRF8和SPIB组合的添加增加了Clec9a报告物活化(图12A)。由IRF8、SPIB和STAT1以及IRF8、SPIB和TSC22D1产生的诱导的pDC也在细胞表面表达MHC-II分子(图12B)，从而支持pDC命运的获得。
在一个实施方案中，将诱导的pDC用TLR7/9攻击，此时观察到与由IRF8和SPIB产生的诱导的pDC相比，用IRF8、SPIB和STAT1(1.3倍)以及IRF8、SPIB和TSC22D1(4.8倍)重新程序化的tdTomato+细胞对IFN-α的分泌增加(图13A)。与IRF8和SPIB诱导的细胞相比，STAT1或TSC22D1的添加也增加了用IRF8、SPIB和STAT1(1.3倍)以及IRF8、SPIB和TSC22D1(4.1倍)重新程序化的tdTomato+细胞对IFN-β的分泌(图13B)。由IRF8、SPIB和STAT1、以及IRF8、SPIB和TSC22D1产生的诱导的pDC不能分泌抗炎细胞因子IL-10。这些数据支持IRF8、SPIB和STAT1、以及IRF8、SPIB和TSC22D1能够诱导朝向诱导的pDC命运的重新程序化和分泌I型干扰素的能力。
在一个实施方案中，造血标志物CD45的表面表达也是pDC的一个显著特征。研究了pDC诱导因子的组合是否能够诱导CD45的表面表达。CD45在1.79±0.33％的用IRF8和SPIB产生的诱导pDC中表达。令人惊讶的是，如果将IKZF1与IRF8和SPIB组合，CD45+群体增加直到10.16±0.91％(5.6倍增加)。
在一个实施方案中，在pDC中TLR7和TLR9对病毒或自身核酸的识别诱导了两种旁路途径，这取决于TLR7和TLR9遇到它们的配体时所在的隔室的类型。MYD88-IRF7途径导致I型干扰素分泌，而MYD88-NF-κB途径导致促炎细胞因子和趋化因子的产生。然后研究了在TLR7/9刺激后，诱导的pDC是否分泌另外的细胞因子(图15)。事实上，经纯化的由IRF8和SPIB的过表达产生的tdTomato+细胞分泌促炎细胞因子IL-6和TNF-α和趋化因子CCL5和CXCL10。重要的是，STAT1、TCF12或TSC22D1向IRF8和SPIB组合的添加以TLR依赖性的方式增加了IL-6、TNF-α、CCL5和CXCL10的分泌。诱导的pDC的TLR攻击增加了用IRF8、SPIB和STAT1(5.6倍)、IRF8、SPIB和TCF12(7.5倍)以及IRF8、SPIB和TSC22D1(3.5倍)重新程序化的tdTomato+细胞对IL-6的分泌，而对于TNF-α观察到类似的增加(分别为1.8、3.1、1.3倍)。用IRF8、SPIB和STAT1(2.5倍)、IRF8、SPIB和TCF12(3.1倍)以及IRF8、SPIB和TSC22D1(2.4倍)重新程序化的tdTomato+细胞对趋化因子CCL5的分泌在TLR攻击后增加。至于CXCL10，由IRF8、SPIB和TCF12、以及IRF8、SPIB和TSC22D1的过表达产生的诱导的pDC在TLR刺激后也将它们的分泌分别增加了2.8和1.7倍。总之，该数据支持我们成功地鉴定足以在不相关细胞类型中诱导pDC的TF组合，它们能够通过两种细胞内途径对TLR7和9刺激作出应答，从而导致I型干扰素分泌和促炎细胞因子和趋化因子。
在一个实施方案中，将每种候选TF的编码区单独克隆到诱导型慢病毒pFUW-TetO载体中，其中TF的表达是在四环素操纵子和最小CMV启动子的控制下。组合使用先前描述的含有在组成活性的人泛素C启动子的控制下的反向四环素反式激活因子M2rtTA的慢病毒载体(FUW-M2rtTA)。用编码TF的质粒、包装构建体和VSV-G包膜蛋白的混合物转染人胚胎肾(HEK)293T细胞。在36、48和60小时后收获病毒上清液，过滤(0.45μm,Corning)并新鲜使用或用Amicon超离心过滤器(Millipore)浓缩40倍。
在一些实施方案中，与由序列表中提供的序列所编码的参考多肽具有相同或类似活性的多肽变体或家族成员可以用在本文所述的组合物、方法和试剂盒中。通常，用于本文所述的组合物、方法和试剂盒中的编码pDC诱导因子的特定多肽的变体将与该特定参考多核苷酸或多肽具有至少约95％、至少约96％、至少约97％、至少约98％、至少约99％或更多序列同一性，如通过本文描述的和本领域技术人员已知的序列比对程序和参数所确定的。
在一个实施方案中，智人干扰素调节因子8(IRF8)、mRNA(SEQ.ID.1)和优化的密码子，或编码相同氨基酸的不同密码子，自然也考虑被对本文所述的核酸的提及涵盖。
在一个实施方案中，智人Spi-B(SPIB)、mRNA(SEQ.ID.3)和优化的密码子，或编码相同氨基酸的不同密码子，自然也考虑被对本文所述的核酸的提及涵盖。
在一个实施方案中，智人AT富集相互作用结构域5A(ARID5A)、mRNA(SEQ.ID.5)和优化的密码子，或编码相同氨基酸的不同密码子，自然也考虑被对本文所述的核酸的提及涵盖。
在一个实施方案中，智人BAF染色质重塑复合物亚基(BCL11A)、mRNA(SEQ.ID.7)和优化的密码子，或编码相同氨基酸的不同密码子，自然也考虑被对本文所述的核酸的提及涵盖。
在一个实施方案中，智人CBFA2/RUNX1配偶体转录辅阻遏物3(CBFA2T3)、mRNA(SEQ.ID.9)和优化的密码子，或编码相同氨基酸的不同密码子，自然也考虑被对本文所述的核酸的提及涵盖。
在一个实施方案中，智人CAMP应答元件结合蛋白3样2(CREB3L2)、mRNA(SEQ.ID.11)和优化的密码子，或编码相同氨基酸的不同密码子，自然也考虑被对本文所述的核酸的提及涵盖。
在一个实施方案中，智人ETS原癌基因1(ETS1)、mRNA(SEQ.ID.13)和优化的密码子，或编码相同氨基酸的不同密码子，自然也考虑被对本文所述的核酸的提及涵盖。
在一个实施方案中，智人同源框A5(HOXA5)、mRNA(SEQ.ID.19)和优化的密码子，或编码相同氨基酸的不同密码子，自然也考虑被对本文所述的核酸的提及涵盖。
在一个实施方案中，智人IKAROS家族锌指1(IKZF1)、mRNA(SEQ.ID.23)和优化的密码子，或编码相同氨基酸的不同密码子，自然考虑被对本文所述的核酸的提及涵盖。
在一个实施方案中，智人信号转导蛋白和转录活化剂1(STAT1)、mRNA(SEQ.ID.45)和优化的密码子，或编码相同氨基酸的不同密码子，自然考虑被对本文所述的核酸的提及涵盖。
在一个实施方案中，智人转录因子4(TCF4)、mRNA(SEQ.ID.41)和优化的密码子，或编码相同氨基酸的不同密码子，自然也考虑被对本文所述的核酸的提及涵盖。
在一个实施方案中，智人转录因子12(TCF12)、mRNA(SEQ.ID.43)和优化的密码子，或编码相同氨基酸的不同密码子，自然也考虑被对本文所述的核酸的提及涵盖。
在一个实施方案中，智人TSC22结构域家族蛋白1(TSC22D1)、mRNA(SEQ.ID.47)和优化的密码子，或编码相同氨基酸的不同密码子，自然考虑被对本文所述的核酸的提及涵盖。
在本文提供的组合物、载体、构建体、方法和试剂盒的一些实施方案中，被使用或被选择从起始体细胞(诸如成纤维细胞或造血谱系细胞、多潜能干细胞、诱导的多能干细胞、癌症或肿瘤细胞)产生pDC的pDC诱导因子的数目是至少两种。在一些实施方案中，被使用或被选择的pDC诱导因子的数目是至少3种、至少4种、至少5种、至少6种、至少7种、至少8种、至少9种、至少10种、至少11种、至少12种、至少13种、至少14种、至少15种、至少16种、至少17种、至少18种、至少19种、至少20种、至少30种、至少33种、至少35种、至少40种或更多种。
在本文所述的组合物、载体、构建体、方法和试剂盒的一些实施方案中，将编码pDC诱导因子诸如IRF8、SPIB、ARID5A、BCL11A、CBFA2T3、CREB3L2、ETS1、HOXA5、IZKF1、TCF4、TCF12和TSC22D1的核酸序列或构建体插入或可操作地连接到合适的表达载体中，用于使用标准的分子生物学技术转染细胞。本文中使用的“载体”表示核酸分子，诸如为插入的核苷酸序列提供有用的生物学或生化特性的dsDNA分子，诸如本文所述的核酸构建体或替换盒。例子包括质粒、噬菌体、自主复制序列(ARS)、着丝粒和能够在体外或在宿主细胞中复制或被复制、或者将期望的核酸区段运送到宿主细胞内期望位置的其它序列。载体可以具有一个或多个限制性内切核酸酶识别位点(无论是I、II、IIs、III和IV型)，在所述位点处可以以可确定的方式切割序列，而不丧失载体的基本生物学功能，并且可以向其中剪接或插入核酸片段以实现其复制和克隆。载体还可以包含一个或多个重组位点，其允许两个核酸分子之间的核酸序列的交换。载体可以进一步提供引物位点(例如用于PCR)、转录和/或翻译起始和/或调节位点、重组信号、复制子、另外的选择标志物等。载体可以进一步包含一种或多种选择标志物，其适用于鉴定用该载体转化的细胞。
在本文所述的组合物、载体、构建体、方法和试剂盒的一些实施方案中，所述表达载体是病毒载体。一些病毒介导的表达方法采用逆转录病毒、腺病毒、慢病毒、副粘病毒、棒状病毒、甲病毒、黄病毒、疱疹病毒、痘病毒和腺相关病毒(AAV)载体，且这样的表达方法已用于基因递送并且是本领域众所周知的。
在本文所述的组合物、载体、构建体、方法和试剂盒的一些实施方案中，所述病毒载体是逆转录病毒。逆转录病毒为基因递送提供了方便平台。使用本领域已知的技术，可以将选择的基因插入载体中并包装在逆转录病毒颗粒中。然后可以将重组病毒分离并在体内或离体递送给受试者的靶细胞。已经描述了许多逆转录病毒系统。参见，例如，美国专利号5,219,740；Miller和Rosman(1989)BioTechniques 7:980-90；Miller,A.D.(1990)HumanGene Therapy 1:5-14；Scarpa等人(1991)Virology 180:849-52；Burns等人(1993)Proc.Natl.Acad.Sci.USA 90:8033-37；Boris-Lawrie和Temin(1993)Curr.Opin.Genet.Develop.3:102-09。在本文所述的组合物、载体、方法和试剂盒的一些实施方案中，所述逆转录病毒是复制缺陷的。逆转录病毒载体系统利用以下事实：含有5′和3′LTR和包装信号的最小载体足以允许载体包装、感染和整合到靶细胞中，前提条件是，病毒结构蛋白在包装细胞系中以反式供给。用于基因转移的逆转录病毒载体的基本优势包括在大多数细胞类型中的有效感染和基因表达、精确的单个拷贝载体向靶细胞染色体DNA中的整合以及逆转录病毒基因组的易于操作。
在本文所述的组合物、载体、构建体、方法和试剂盒的一些实施方案中，所述病毒载体是基于腺病毒的表达载体。与整合到宿主基因组中的逆转录病毒不同，腺病毒在染色体外持续存在，因此将与插入诱变相关的风险降至最低(Haj-Ahmad和Graham(1986)J.Virol.57:267-74；Bett等人(1993)J.Virol.67:5911-21；Mittereder等人(1994)HumanGene Therapy 5:717-29；Seth等人(1994)J.Virol.68:933-40；Barr等人(1994)GeneTherapy 1:51-58；Berkner,K.L.(1988)BioTechniques 6:616-29；和Rich等人(1993)Human Gene Therapy4:461-76)。腺病毒载体感染多种细胞，具有广宿主范围，表现出高感染效率，指导异源基因的高水平表达，并实现那些基因在体内的长期表达。该病毒作为无细胞病毒粒子具有完全感染性，因此不必需注射生产细胞系。就安全性而言，腺病毒与严重的人病理学无关，并且源自该病毒的重组载体可以通过病毒基因组的早期区域1(“E1”)中的缺失而使得复制缺陷。也可以相对容易地大量生产腺病毒。用于本文所述的组合物、载体、方法和试剂盒中的腺病毒载体可以衍生自各种腺病毒血清型中的任一种，包括、但不限于腺病毒的超过40种血清型毒株(诸如血清型2、5、12、40和41)中的任一种。本文使用的腺病毒载体优选地是复制缺陷的并且含有可操作地连接至合适启动子的感兴趣的pDC诱导因子。
在本文所述的组合物、载体、构建体、方法和试剂盒的一些实施方案中，使用一种或多种诱导型慢病毒载体引入或递送编码pDC诱导因子诸如IRF8、SPIB、ARID5A、BCL11A、CBFA2T3、ETS1、HOXA5、IKZF1、STAT1、TCF4、TCF12和TSC22D1的核酸序列。在一些实施方案中，通过使细胞(所述细胞在处于诱导型启动子的控制下或可操作地连接至诱导型启动子的表达载体中具有至少一种pDC诱导因子)与调节剂(例如，多西环素)或其它诱导剂接触，可以实现使用一种或多种诱导型慢病毒载体递送的pDC诱导因子的表达的控制。当使用一些类型的诱导型慢病毒载体时，使这样的细胞与诱导剂接触诱导pDC诱导因子的表达，而调节剂的撤去抑制表达。当使用其它类型的诱导型慢病毒载体时，调节剂的存在抑制表达，而调节剂的除去允许表达。本文中使用的术语“表达的诱导”表示，在例如诱导剂存在的情况下，或在一种或多种造成基因在细胞中的内源性表达的试剂或因子存在的情况下，基因的表达，诸如由诱导型病毒载体编码的pDC诱导因子的表达。
在本文描述的方面的一些实施方案中，使用多西环素(Dox)诱导型慢病毒系统。与逆转录病毒不同，慢病毒能够转导静止细胞，使其适合转导更广泛种类的造血细胞类型。例如，pFUW-tetO慢病毒系统已被显示以高效转导原代造血祖细胞。
在本文所述的方法的一些实施方案中，使用非整合载体(例如，腺病毒)引入或递送编码pDC诱导因子、诸如IRF8(SEQ.ID.1、SEQ.ID.2)、SPIB(SEQ.ID.3、SEQ.ID.4)、ARID5A(SEQ.ID.5、SEQ.ID.6)、BCL11A(SEQ.ID.7、SEQ.ID.8)、CBFA2T3(SEQ.ID.9、SEQ.ID.10)、CREB3L2(SEQ.ID.11、SEQ.ID.12)、ETS1(SEQ.ID.13、SEQ.ID.14)、HDAC5(SEQ.ID.15、SEQ.ID.16)、HHEX(SEQ.ID.17、SEQ.ID.18)、HOXA5(SEQ.ID.19、SEQ.ID.20)、ID3(SEQ.ID.21、SEQ.ID.22)、IKZF1(SEQ.ID.23、SEQ.ID.24)、IKZF2(SEQ.ID.25、SEQ.ID.26)、IKZF3(SEQ.ID.27、SEQ.ID.28)、IKZF5(SEQ.ID.29、SEQ.ID.30)、IRF7(SEQ.ID.31、SEQ.ID.32)、MEF2C(SEQ.ID.33、SEQ.ID.34)、MYB(SEQ.ID.35、SEQ.ID.36)、RUNX2(SEQ.ID.37、SEQ.ID.38)、STAT3(SEQ.ID.39、SEQ.ID.40)、TCF4(SEQ.ID.41、SEQ.ID.42)、TCF12(SEQ.ID.43、SEQ.ID.44)、STAT1(SEQ.ID.45、SEQ.ID.46)和TSC22D1(SEQ.ID.47、SEQ.ID.48)的核酸序列。虽然整合载体(诸如逆转录病毒载体)整合到宿主细胞基因组中并可能破坏正常基因功能，但是非整合载体通过染色体外转录控制基因产物的表达。由于非整合载体不会成为宿主基因组的一部分，因此非整合载体倾向于在细胞群中瞬时表达核酸。这部分地由于非整合载体经常使得复制缺陷的事实。因此，非整合载体具有胜过逆转录病毒载体的几个优点，包括、但不限于：(1)不会破坏宿主基因组，和(2)瞬时表达，以及(3)没有剩余的病毒整合产物。用于与本文所述方法一起使用的非整合载体的一些非限制性例子包括腺病毒、杆状病毒、甲病毒、小RNA病毒和痘苗病毒。在本文所述的方法的一些实施方案中，所述非整合病毒载体是腺病毒。非整合病毒载体的其它优点包括以高滴度生产它们的能力、它们在体内的稳定性以及它们对宿主细胞的有效感染。
在一些实施方案中，用于在本文所述的组合物、载体、构建体、方法和试剂盒中产生诱导的pDC的核酸构建体和载体可以进一步包含一种或多种编码用于细胞的阳性和阴性选择的选择标志物的序列。这样的选择标志物序列通常可以提供对抗生素的抗性或敏感性特性，所述特性在没有引入核酸构建体的情况下通常不会在细胞中发现。选择标志物可以与选择剂诸如抗生素结合使用，以在培养物中选择表达插入的核酸构建体的细胞。编码阳性选择标志物的序列通常提供抗生素抗性，即，当阳性选择标志物序列存在于细胞的基因组中时，所述细胞对抗生素或试剂是敏感的。编码阴性选择标志物的序列通常提供对抗生素或试剂的敏感性，即，当阴性选择标志物存在于细胞的基因组中时，细胞对抗生素或试剂是敏感的。
在一些实施方案中，用于制备在本文所述的组合物、载体、构建体、方法及其试剂盒中的诱导的pDC的核酸构建体和载体可以进一步包含用于构建体或其它载体遗传元件的调节、表达、稳定化的其它核酸元件，例如，本领域普通技术人员已知的启动子、增强子、TATA盒、核糖体结合位点、IRES、2A-样自切割序列。
用于制备在本文所述的组合物、载体、构建体、方法和试剂盒中的诱导的pDC的核酸构建体和载体可以进一步包含2A-样自切割序列。自切割的18-22个氨基酸长的2A肽介导脯氨酸和甘氨酸残基之间的“核糖体跳跃”并抑制肽键形成，而不影响下游翻译。这些肽允许将多种蛋白编码为多蛋白，所述多蛋白在翻译后解离成组分蛋白。可以根据本发明使用的2A-样自切割序列的例子包括、但不限于来自细小RNA病毒科的那些，包括口蹄疫病毒属诸如口蹄疫病毒(FMDV)、马甲型鼻炎病毒(ERAV)、Thosea asigna病毒(TaV)和猪捷申病毒-1(PTV-1)和心病毒属诸如Theilovirus(例如，Theiler氏鼠脑脊髓炎)和脑心肌炎病毒。
在本文所述的组合物、载体、构建体、方法和试剂盒的一些实施方案中，所述pDC诱导因子诸如IRF8(SEQ.ID.1,SEQ.ID.2)、SPIB(SEQ.ID.3,SEQ.ID.4)、ARID5A(SEQ.ID.5,SEQ.ID.6)、BCL11A(SEQ.ID.7,SEQ.ID.8)、CBFA2T3(SEQ.ID.9,SEQ.ID.10)、CREB3L2(SEQ.ID.11,SEQ.ID.12)、ETS1(SEQ.ID.13,SEQ.ID.14)、HOXA5(SEQ.ID.19,SEQ.ID.20)、IKZF1(SEQ.ID.23,SEQ.ID.24)、TCF4(SEQ.ID.41,SEQ.ID.42)、TCF12(SEQ.ID.43,SEQ.ID.44)、STAT1(SEQ.ID.45,SEQ.ID.46)和TSC22D1(SEQ.ID.47,SEQ.ID.48)作为合成的、修饰的RNA提供，或者作为合成的、修饰的RNA引入或递送到细胞中，如美国专利公开2012-0046346-A1中所述，其内容通过引用整体并入本文。在其中根据本文所述的方法使用合成的、修饰的RNA将细胞重新程序化为诱导的pDC的那些实施方案中，所述方法可以涉及细胞的重复接触或涉及编码pDC诱导因子的合成的、修饰的RNA的重复转染，诸如例如，至少2次、至少3次、至少4次、至少5次、至少6次、至少7次、至少8次、至少9次、至少10次、至少11次、至少12次、至少13次、至少14次、至少15次、至少16次、至少17次、至少18次、至少19次、至少20次、至少25次、至少30次或更多次转染。
除了一种或多种修饰的核苷之外，用于本文所述的组合物、载体、构建体、方法和试剂盒中的修饰的mRNA还可以包含本领域技术人员已知的和如在美国专利公开2012-0046346-A1和20120251618A1以及PCT公开WO2012/019168中描述的任何另外修饰。这样其它组分包括，例如，5'帽(例如，抗反向帽类似物(ARCA)帽，其含有5′-5′-三磷酸鸟嘌呤-鸟嘌呤键，其中一个鸟嘌呤含有N7甲基基团以及3′-O-甲基基团；使用重组痘苗病毒加帽酶和重组2′-O-甲基转移酶产生的帽，其可以在mRNA的最5′侧核苷酸和鸟嘌呤核苷酸之间产生规范的5′-5′-三磷酸键，其中鸟嘌呤含有N7甲基化，且最终的5′-核苷酸含有2′-O-甲基，从而产生Cap1结构)；聚腺苷酸尾巴(例如，大于30个核苷酸长度、大于35个核苷酸长度、至少40个核苷酸、至少45个核苷酸、至少55个核苷酸、至少60个核苷酸、至少70个核苷酸、至少80个核苷酸、至少90个核苷酸、至少100个核苷酸、至少200个核苷酸、至少300个核苷酸、至少400个核苷酸、至少500个核苷酸、至少600个核苷酸、至少700个核苷酸、至少800个核苷酸、至少900个核苷酸、至少1000个核苷酸或更长的聚-A尾巴)；Kozak序列；3′非翻译区(3′UTR)；5′非翻译区(5′UTR)；一种或多种能够从核酸中切除的内含子核苷酸序列，或它们的任意组合。
用于本文所述的组合物、载体、构建体、方法和试剂盒中的修饰的mRNA可以进一步包含内部核糖体进入位点(IRES)。IRES可以充当唯一的核糖体结合位点，或可以充当mRNA的多个核糖体结合位点之一。含有多于一个功能性核糖体结合位点的mRNA可以编码几种肽或多肽，诸如本文所述的pDC诱导因子，它们由核糖体(“多顺反子mRNA”)独立翻译。当给核酸提供IRES时，进一步任选地提供第二可翻译区。可以根据本发明使用的IRES序列的例子包括、但不限于来自小RNA病毒(例如FMDV)、害虫病毒(CFFV)、脊髓灰质炎病毒(PV)、脑心肌炎病毒(ECMV)、口蹄疫病毒(FMDV)、丙型肝炎病毒(HCV)、经典猪瘟病毒(CSFV)、鼠白血病病毒(MLV)、猿猴免疫缺陷病毒(SW)或蟋蟀麻痹病毒(CrPV)的那些。
在本文所述的组合物、载体、构建体、方法和试剂盒的一些实施方案中，所述合成的、修饰的RNA分子包含至少一种修饰的核苷。在本文所述的组合物、载体、方法和试剂盒的一些实施方案中，所述合成的、修饰的RNA分子包含至少两种修饰的核苷。
在本文所述的组合物、载体、构建体、方法和试剂盒的一些实施方案中，所述修饰的核苷选自：5-甲基胞嘧啶(5mC)、N6-甲基腺苷(m6A)、3,2′-O-二甲基尿苷(m4U)、2-硫代尿苷(s2U)、2′氟代尿苷、假尿苷、2′-O-甲基尿苷(Um)、2′脱氧尿苷(2′dU)、4-硫代尿苷(s4U)、5-甲基尿苷(m5U)、2′-O-甲基腺苷(m6A)、N6,2′-O-二甲基腺苷(m6Am)、N6,N6,2′-O-三甲基腺苷(m62Am)、2′-O-甲基胞苷(Cm)、7-甲基鸟苷(m7G)、2′-O-甲基鸟苷(Gm)、N2,7-二甲基鸟苷(m2,7G)、N2,N2,7-三甲基鸟苷(m2,2,7G)和肌苷(I)。在一些实施方案中，所述修饰的核苷是5-甲基胞嘧啶(5mC)、假尿嘧啶或它们的组合。
修饰的mRNA不需要沿分子的整个长度进行均匀修饰。不同的核苷酸修饰和/或主链结构可以存在于核酸中的不同位置。本领域普通技术人员将理解，核苷酸类似物或其它修饰可以位于核酸的任何位置，使得核酸的功能不会显著降低。修饰也可以是5'或3'末端修饰。核酸可以含有最少一个且最多100％的修饰的核苷酸，或任何中间百分比，诸如至少50％修饰的核苷酸、至少80％修饰的核苷酸或至少90％修饰的核苷酸。
在本公开内容的一些实施方案中，所述载体或构建体是复制病毒载体或颗粒，诸如副粘病毒载体、棒状病毒载体、甲病毒和/或黄病毒颗粒，或非病毒载体或颗粒，诸如裸甲病毒或黄病毒RNA复制子。
在一些实施方案中，优选但并非绝对必要的是，给定的核苷在分子中的每次出现都被修饰(例如，每个胞嘧啶是修饰的胞嘧啶，例如5-甲基胞嘧啶，每个尿嘧啶是修饰的尿嘧啶，例如，假尿嘧啶，等)。例如，修饰的mRNA可以包含修饰的嘧啶诸如尿嘧啶或胞嘧啶。在一些实施方案中，核酸中至少25％、至少50％、至少80％、至少90％或100％的尿嘧啶被修饰的尿嘧啶替代。还考虑到相同核苷的不同出现可以在给定的合成的、修饰的RNA分子中以不同的方式修饰。修饰的尿嘧啶可以被具有单一独特结构的化合物替代，或者可以被具有不同结构(例如，2、3、4种或更多种独特结构)的多种化合物替代。在一些实施方案中，核酸中至少25％、至少50％、至少80％、至少90％或100％的胞嘧啶可以被修饰的胞嘧啶替代。修饰的胞嘧啶可以被具有单一独特结构的化合物替代，或者可以被具有不同结构(例如，2、3、4种或更多种独特结构)的多种化合物替代(例如，一些胞嘧啶修饰为5mC，其它修饰为2′-O-甲基胞嘧啶或其它胞嘧啶类似物)。这样的多修饰的合成RNA分子可以通过使用包含所有期望的修饰核苷的核糖核苷共混物或混合物来产生，使得当合成RNA分子时，仅期望的修饰核苷被掺入所得编码pDC诱导因子的RNA分子中。
在某些实施方案中，期望的是，在细胞内降解引入细胞中的修饰核酸，例如如果期望精确的蛋白产生时机。因此，在本文所述的组合物、载体、方法和试剂盒的一些实施方案中，本文提供了修饰的核酸，其包含能够在细胞内以定向方式被起作用的降解结构域。
虽然应理解诱导的pDC可以通过以核酸(DNA或RNA)或氨基酸序列的形式递送pDC诱导因子来产生，但是在本文所述的组合物、载体、方法和试剂盒的一些实施方案中，诱导的pDC可以使用其它方法来诱导，例如，通过用试剂(诸如小分子或小分子混合物，其诱导一种或多种pDC诱导因子的表达)处理细胞。
使用本文所述的组合物、载体、方法和试剂盒检测引入细胞中或在细胞群中诱导的pDC诱导因子的表达，可以通过本领域技术人员已知的几种技术中的任一种来实现，所述技术包括、例如Western印迹分析、免疫细胞化学和荧光介导的检测。
为了区分pDC诱导因子的给定组合是否已产生诱导的pDC，可以测量一种或多种DC活性或参数，诸如，在一些实施方案中，表面抗原的差异表达。使用本文所述的组合物、载体、方法和试剂盒产生诱导的DC，例如优选造成内源性pDC特有的细胞表面表型(诸如CD45和MHC-II)的出现。
DC通过其功能行为最可靠地与其它免疫细胞区分开。DC表型或DC活性的功能方面，诸如诱导的pDC分泌细胞因子的能力，可以由本领域技术人员使用本领域已知的常规方法容易地确定。在本文描述的方面的一些实施方案中，可以使用鉴定重新程序化因子的功能测定。例如，在一些实施方案中，细胞因子分泌可以用于证实使用本文所述的组合物、载体、方法和试剂盒产生的诱导pDC的免疫调节特性。特别是，通过TLR7和TLR9途径对细胞内DNA做出响应和分泌I型干扰素的能力与表征pDC功能特别相关。
本文中使用的“细胞参数”、“DC参数”或“细胞因子分泌”表示内源或天然DC的可测量组分或质量，特别是可以准确测量的组分。细胞参数可以是与细胞的表型、功能或行为相关的任何可测量参数。这样的细胞参数包括DC或DC群体的特征和标志物的变化，包括、但不限于活力、细胞生长、一种或多种标志物或标志物组合的表达的变化，所述标志物诸如细胞表面决定簇诸如受体、蛋白(包括其构象或翻译后修饰)、脂质、碳水化合物、有机或无机分子、核酸(例如mRNA、DNA)、总基因表达模式等。使用本领域技术人员已知的多种测定中的任一种，可以测量这样的细胞参数。例如，通过测定诸如锥虫蓝排除、CFSE稀释和3H-胸苷掺入，可以测量活力和细胞生长。例如，使用流式细胞计数测定、Western印迹技术或显微术方法，可以测量蛋白或多肽标志物的表达。例如，使用RNA-测序方法和定量或半定量实时PCR测定，可以测定基因表达概况。细胞参数还可以表示功能参数或功能活性。虽然大多数细胞参数将提供定量读出值，但在一些情况下，半定量或定性结果可以是可接受的。读出值可以包括单个确定值，或可以包括平均值、中位值或方差等。特有地，可以从多个相同测定中为每种参数获得一系列参数读出值。预见到变异性，并且将使用标准统计方法和用于提供单个值的通用统计方法来获得每组测试参数的一系列值。
在本文所述的组合物、载体、方法和试剂盒的一些实施方案中，可以使用另外的因子和试剂来增强诱导的pDC重新程序化。例如，修饰表观遗传途径的因子和试剂可以用于促进重新程序化为诱导的pDC。
根据本文描述的组合物、载体、方法和试剂盒，基本上任何原代体细胞类型都可以用于产生诱导的pDC或将体细胞重新程序化为诱导的pDC。这样的原代体细胞类型还包括其它干细胞类型，包括多能干细胞，诸如诱导的多能干细胞(iPS细胞)；其它多潜能干细胞；寡能干细胞；和单能干细胞。可用于本文所述方法的各个方面和实施方案中的原代体细胞的一些非限制性例子包括、但不限于成纤维细胞、上皮细胞、内皮细胞、神经元细胞、脂肪细胞、心脏细胞、骨骼肌细胞、造血细胞或免疫细胞、肝细胞、脾细胞、肺细胞、循环血细胞、胃肠细胞、肾细胞、骨髓细胞和胰腺细胞，以及衍生出那些细胞的干细胞。所述细胞可以是从任何体组织分离的原代细胞，所述体组织包括、但不限于脾、骨髓、血液、脑、肝、肺、肠道、胃、肠、脂肪、肌肉、子宫、皮肤、脾、内分泌器官、骨骼等。在一些实施方案中，术语“体细胞”进一步涵盖在培养物中生长的原代细胞，前提条件是，体细胞不是永生化的。当将细胞维持在体外条件下时，可以使用常规的组织培养条件和方法，并且它们是本领域技术人员已知的。各种原代体细胞的分离和培养方法完全是在本领域技术人员的能力范围内。
在本文描述的这些方面和所有这样的方面的一些实施方案中，所述体细胞是成纤维细胞。
在本文描述的这些方面和所有这样的方面的一些实施方案中，所述体细胞可以是造血谱系细胞。
在本文描述的这些方面和所有这样的方面的一些实施方案中，所述体细胞可以是癌细胞或肿瘤细胞。
在本文所述的组合物、载体、构建体、方法和试剂盒的一些实施方案中，待重新程序化或制成诱导的pDC细胞的体细胞是造血来源的细胞。本文中使用的术语“造血衍生的细胞”、“造血的衍生的分化细胞”、“造血谱系细胞”和“造血来源的细胞”表示衍生自或分化自多潜能造血干细胞(HSC)的细胞。因此，用于与本文所述的组合物、载体、构建体、方法和试剂盒一起使用的造血谱系细胞包括多潜能、寡能和谱系限制的造血祖细胞、粒细胞(例如，早幼粒细胞、嗜中性粒细胞、嗜酸性粒细胞、嗜碱性粒细胞)、红细胞(例如，网织红细胞、红细胞)、凝血细胞(例如，幼巨核细胞、产生血小板的巨核细胞、血小板)、单核细胞(例如，单核细胞、巨噬细胞)、树突细胞和淋巴细胞(例如，T-淋巴细胞(其携带T-细胞受体(TCR))、B-淋巴细胞或B细胞(其表达免疫球蛋白并产生抗体)、NK细胞、NKT细胞和先天性淋巴细胞)。本文中使用的术语“造血祖细胞”表示能够分化为造血系统的两种或更多种细胞类型的多潜能、寡能和谱系限制的造血细胞，包括、但不限于，粒细胞、单核细胞、红细胞、巨核细胞和淋巴细胞B-细胞和T-细胞。造血祖细胞涵盖多能祖细胞(MPP)、共同髓样祖细胞(CMP)、共同淋巴样祖细胞(CLP)、粒细胞-单核细胞祖细胞(GMP)和前巨核细胞-红细胞祖细胞。谱系限制的造血祖细胞包括巨核细胞-红细胞祖细胞(MEP)、原B细胞、前B细胞、前原B细胞、原T细胞、双阴性T细胞、原-NK细胞、前粒细胞/巨噬细胞、粒细胞/巨噬细胞祖(GMP)细胞和原-肥大细胞(ProMC)。
用于本文所述的组合物、载体、方法和试剂盒中的造血来源的细胞可以获得自已知包含这些细胞的任何来源，诸如胎儿组织、脐带血、骨髓、外周血、动员的外周血、脾、肝、胸腺、淋巴液等。从这些来源获得的细胞可以使用本领域技术人员可接受的任何方法离体扩增，然后与本文描述的用于制备诱导的pDC的组合物、载体、构建体、方法和试剂盒一起使用。例如，使用本领域技术人员可接受的任何程序，可以对细胞进行分选、分级分离、处理以除去特定细胞类型，或以其它方式操作以获得用于本文所述的方法中的细胞群体。可以收集单核淋巴细胞，例如，通过如美国专利号4,690,915中所述使用连续流动室分离器的重复淋巴细胞除去法，或使用CLP方法的亲和纯化步骤分离，诸如使用细胞计数器的流式细胞计量术、磁性分离、使用抗体或蛋白包被的珠子、亲和色谱法或固体支持亲和分离(其中根据细胞对特定蛋白或蛋白类型的表达或表达缺乏将细胞保留在基质上)、或批式纯化(使用一种或多种针对目标细胞类型特异性表达的一种或多种表面抗原的抗体)。造血来源的细胞也可以从外周血获得。在从外周血收获细胞之前，可以用细胞因子诸如例如粒细胞-集落刺激因子治疗受试者，以促进细胞从骨髓向血液隔室的迁移和/或促进目标群体的活化和/或增殖。例如，可以采用适用于鉴定表面蛋白的任何方法从异质群体分离造血来源的细胞。在一些实施方案中，获得造血来源的细胞(诸如淋巴细胞)的克隆群体。在一些实施方案中，造血来源的细胞不是克隆群体。
此外，关于本文所述的组合物、载体、构建体、方法和试剂盒的各个方面和实施方案，可以从任何哺乳动物物种获得体细胞，非限制性例子包括鼠、牛、猿猴、猪、马、羊或人细胞。在一些实施方案中，所述体细胞是人细胞。在一些实施方案中，所述细胞来自非人生物体，诸如非人哺乳动物。
一般而言，本文所述的制备诱导的pDC的方法涉及在本领域普通技术人员可获得和众所周知的任何培养基中培养或扩增体细胞，诸如造血来源的细胞。这样的培养基包括、但不限于Dulbecco氏改良的
Figure BDA0003647639210000371
Figure BDA0003647639210000372
(DMEM)、DMEM
Figure BDA0003647639210000377
Figure BDA0003647639210000378
Iscove氏改良的
Figure BDA0003647639210000376
RPMI-1640
Figure BDA0003647639210000375
以及用于培养和扩增DC的无血清培养基。许多培养基也可作为含钠或不含钠的低葡萄糖制剂获得。在一些实施方案中，可以给与本文所述的方法一起使用的培养基补充一种或多种免疫刺激性细胞因子。常用生长因子包括、但不限于G-CSF、GM-CSF、TNF-α、IL-4、IL-3、Flt-3配体和kit配体。另外，在优选的实施方案中，所述免疫刺激性细胞因子选自白介素(例如，IL-1α、IL-1β、IL-2、IL-3、IL-4、IL-6、IL-8、IL-9、IL-10、IL-12、IL-18、IL-19、IL-20)、干扰素(例如，IFN-α、IFN-β、IFN-γ)、肿瘤坏死因子(TNF)、转化生长因子-β(TGF-β)、粒细胞集落刺激因子(G-CSF)、巨噬细胞集落刺激因子(M-CSF)、粒细胞-巨噬细胞集落刺激因子(GM-CSF)、Flt-3配体和kit配体。
例如，可以将培养中的细胞维持在悬浮液中或附着至固体支持物(诸如细胞外基质组分)，或铺板在饲养细胞上。在本文所述的方法中使用的细胞可以需要促进它们附着到固体支持物的额外因子，在一些实施方案中，诸如I型和II型胶原、硫酸软骨素、纤连蛋白、“超纤连蛋白”和纤连蛋白样聚合物、明胶、聚-D和聚-L-赖氨酸、凝血酶敏感蛋白和玻璃体结合蛋白。在一些实施方案中，细胞适合在悬浮培养物中生长。适合悬浮的宿主细胞通常是单分散的或以松散聚集体形式生长而没有大量聚集。适合悬浮的宿主细胞包括适用于悬浮培养而无需适应或操作的细胞(例如，造血来源的细胞，诸如淋巴样细胞)和通过附着依赖性细胞(例如，上皮细胞、成纤维细胞)的改变或适应而成为适合悬浮的细胞。
在本文描述的这些方面和所有这样的方面的一些实施方案中，所述分离的诱导的pDC进一步包含药学上可接受的载体以施用给有需要的受试者。
在一些方面，本文还提供了使用pDC诱导组合物和载体治疗需要治疗的受试者以诱导抗原特异性免疫应答以消除癌细胞或传染原的方法，以及制备本文所述的诱导的pDC的方法，或使用用pDC诱导因子、pDC诱导组合物和载体的任何组合或本文描述的制备诱导的pDC的方法产生的分离的诱导的pDC及其细胞克隆。在这样的治疗方法中，可以首先从受试者中分离体细胞，诸如成纤维细胞或造血谱系细胞，并且如本文所述用分别包含表达载体或合成mRNA的pDC诱导组合物转导或转染分离的细胞。然后可以将使用pDC诱导因子、pDC诱导组合物和载体的任何组合或本文描述的制备诱导的pDC的方法产生的分离的诱导的pDC施用给受试者，诸如通过将诱导的pDC全身注射给受试者。
在一些方面，本文还提供了使用本文描述的pDC诱导组合物和载体以及pDC诱导因子的任何组合治疗需要治疗的受试者以诱导抗原特异性免疫应答以消除癌细胞或传染原的方法。在这样的治疗方法中，如本文所述，用包含表达载体的pDC诱导组合物转导癌细胞。可以首先将癌细胞从受试者中分离，用包含表达载体的pDC诱导组合物转导，并且然后施用给受试者，诸如通过全身注射。可替换地，可以用包含病毒表达载体的pDC诱导组合物原位或在体内转导癌细胞。
在本文所述的治疗方法的一些实施方案中，可以将使用本文所述的组合物、载体、构建体、方法和试剂盒产生的重新程序化的诱导的pDC直接使用或施用给需要免疫疗法的受试者。因此，本文所述方法的各个实施方案涉及将有效量的使用本文所述的组合物、载体、方法和试剂盒中的任一种产生的诱导的pDC或诱导的pDC群体施用给需要细胞疗法的个体或受试者。被施用的细胞或细胞群体可以是自体群体，或衍生自一种或多种异源来源。此外，可以以允许它们迁移到淋巴结并活化效应T细胞的方式施用这样的诱导的pDC。
本领域技术人员已知多种将细胞施用给受试者的方法。这样的方法可以包括全身注射，例如，静脉内注射，或者将细胞植入进受试者的靶部位。可以将细胞插入递送装置中，该递送装置有助于通过注射或植入进受试者而引入。这样的递送装置可以包括用于将细胞和流体注射到接受受试者的身体中的管子，例如导管。在一个优选的实施方案中，所述管子还另外具有针头，例如，通过该针头可以将细胞在期望的位置处引入受试者中。细胞可以以多种不同的形式制备用于递送。例如，当被包含在这样的递送装置中时，可以将细胞悬浮在溶液或凝胶中或嵌入支持基质中。可以将细胞与细胞在其中保持活力的药学上可接受的载体或稀释剂混合。
因此，通过本文所述的方法产生的细胞可以用于制备细胞以治疗或减轻几种癌症和肿瘤，包括、但不限于乳腺癌、前列腺癌、淋巴瘤、皮肤癌、胰腺癌、结肠癌、黑素瘤、恶性黑素瘤、卵巢癌、脑癌、原发性脑癌、头颈癌、神经胶质瘤、胶质母细胞瘤、肝癌、膀胱癌、非小细胞肺癌、头或颈癌、乳腺癌、卵巢癌、肺癌、小细胞肺癌、威尔曼瘤、宫颈癌、睾丸癌、膀胱癌、胰腺癌、胃癌、结肠癌、前列腺癌、生殖泌尿癌、甲状腺癌、食管癌、骨髓瘤、多发性骨髓瘤、肾上腺癌、肾细胞癌、子宫内膜癌、肾上腺皮质癌、恶性胰腺胰岛素瘤、恶性类癌、绒毛膜癌、蕈样肉芽肿病、恶性高钙血症、宫颈增生、白血病、急性淋巴细胞白血病、慢性淋巴细胞白血病、急性髓性白血病、慢性髓性白血病、慢性粒细胞白血病、急性粒细胞白血病、毛细胞白血病、神经母细胞瘤、横纹肌肉瘤、卡波西氏肉瘤、真性红细胞增多症、原发性血小板增多症、霍奇金病、非霍奇金淋巴瘤、软组织肉瘤、成骨性肉瘤、原发性巨球蛋白血症和视网膜母细胞瘤等。
除了上述之外，本发明的方法可以用于预防或消除已知会诱发某些癌症的病原体的感染。用于本文提供的癌症疫苗中的特别感兴趣的病原体包括乙型肝炎病毒(肝细胞癌)、丙型肝炎病毒(肝细胞瘤)、爱泼斯坦-巴尔病毒(EBV)(伯基特淋巴瘤、鼻咽癌、免疫抑制个体中的PTLD)、HTLVL(成体T细胞白血病)、致癌人乳头瘤病毒16、18、33、45型(成人宫颈癌)和细菌幽门螺杆菌(Helicobacter pylori)(B细胞胃淋巴瘤)。在文献中广泛描述了可以在哺乳动物和更特别是人类中充当抗原的其它医学相关微生物，例如，C.G.A Thomas,Medical Microbiology,Bailliere Tindall,(1983)。
除了上述之外，本发明的方法可以用于病毒感染。示例性的病毒病原体包括、但不限于感染哺乳动物和更特别是人类的感染性病毒。感染性病毒的例子包括、但不限于：逆转录病毒科(例如，人免疫缺陷病毒，诸如HIV-I(也被称作HTLV-III，LAV或HTLV-III/LAV，或HIV-III；和其它分离株，诸如HIV-LP)；细小RNA病毒科(例如脊髓灰质炎病毒、甲型肝炎病毒；肠道病毒、人柯萨奇病毒、鼻病毒、埃可病毒)；杯状病毒科(例如引起胃肠炎的毒株)；披膜病毒科(例如马脑炎病毒、风疹病毒)；黄病毒科(例如登革热病毒、脑炎病毒、黄热病病毒)；冠状病毒科(例如冠状病毒诸如SARS冠状病毒)；弹状病毒科(例如水疱性口炎病毒、狂犬病病毒)；纤丝病毒科(例如埃博拉病毒)；副粘病毒(例如副流感病毒、腮腺炎病毒、麻疹病毒、呼吸道合胞体病毒)；正粘病毒科(例如流感病毒)；布尼亚病毒科(例如汉坦病毒、bunga病毒、白蛉病毒和Nairo病毒)；沙粒病毒科(出血热病毒)；呼肠孤病毒科(例如里奥病毒、环状病毒和轮状病毒)；双RNA病毒科；嗜肝病毒科(乙型肝炎病毒)；细小病毒科(细小病毒)；乳多空病毒科(乳头状瘤病毒、多瘤病毒)；腺病毒科(大多数腺病毒)；疱疹病毒科单纯疱疹病毒(HSV)1和2、水痘带状疱疹病毒、巨细胞病毒(CMV)、疱疹病毒；痘病毒科(天花病毒、痘苗病毒、痘病毒)；和虹彩病毒科(例如非洲猪瘟病毒)；和未分类的病毒(例如海绵状脑病的病原体、丁型肝炎的病原体(被认为是乙型肝炎病毒的缺陷卫星)、非甲非乙型肝炎的病原体(1类＝血液(interaally)传播；2类＝胃肠外传播(即丙型肝炎)；诺瓦克病毒(Norwalk)和有关的病毒和星状病毒)。
除了上述之外，本发明的方法可以用于靶向脊椎动物中的革兰氏阴性和革兰氏阳性细菌。这样的革兰氏阳性细菌包括、但不限于巴斯德氏菌属种(Pasteurella sp.)、葡萄球菌属种(Staphylococci sp.)和链球菌属种(Streptococcus sp.)。革兰氏阴性细菌包括、但不限于大肠杆菌(Escherichia coli)、假单胞菌属种(Pseudomonas sp.)和沙门氏菌属种(Salmonella sp.)。感染性细菌的具体例子包括、但不限于：幽门螺杆菌(Helicobacter pyloris)、伯氏疏螺旋体(Borella burgdorferi)、嗜肺军团菌(Legionella pneumophilia)、分枝杆菌属种(例如结核分枝杆菌(M.tuberculosis)、鸟分枝杆菌(M.avium)、胞内分枝杆菌(M.intracellulare)、堪萨斯分枝杆菌(M.kansaii)、戈登分枝杆菌(M.gordonae))、金黄色葡萄球菌(Staphylococcus aureus)、淋病奈瑟球菌(Neisseria gonorrhoeae)、脑膜炎奈瑟球菌(Neisseria meningitidis)、单核细胞增生李斯特菌(Listeria monocytogenes)、酿脓链球菌(Streptococcus pyogenes)(A群链球菌)、无乳链球菌(Streptococcus agalactiae)(B群链球菌)、链球菌属(viridans group)、粪链球菌(Streptococcus faecalis)、牛链球菌(Streptococcus bovis)、链球菌属(厌氧消化种)、肺炎链球菌(Streptococcus pneumoniae)、病原性弯曲杆菌属种(Campylobactersp.)、肠球菌属种(Enterococcus sp.)、流感嗜血杆菌(Haemophilus infuenzae)、炭疽芽孢杆菌(Bacillus antracis)、白喉棒杆菌(Corynebacterium diphtheriae)、棒杆菌属种(Corynebacterium sp.)、猪红斑丹毒丝菌(Erysipelothrix rhusiopathiae)、产气英膜梭菌(Clostridium perfringers)、破伤风梭菌(Clostridium tetani)、产气肠杆菌(Enterobacter aerogenes)、肺炎克雷伯氏菌(Klebsiella pneumoniae)、多杀巴斯德氏菌(Pasturella multocida)、拟杆菌属种(Bacteroides sp.)、具核梭杆菌(Fusobacteriumnucleatum)、念珠状链杆菌(Streptobacillus moniliformis)、苍白密螺旋体(Treponemapallidium)、极细密螺旋体(Treponema pertenue)、钩端螺旋体属(Leptospira)、立克次氏体属(Rickettsia)和以色列放线菌(Actinomyces israelii)。
除了上述之外，本发明的方法可以用于靶向病原体，所述病原体包括、但不限于感染哺乳动物和更特别是人类的感染性真菌和寄生虫。感染性真菌的例子包括、但不限于：新型隐球菌(Cryptococcus neoformans)、荚膜组织胞浆菌(Histoplasma capsulatum)、粗球孢子菌(Coccidioides immitis)、皮炎芽生菌(Blastomyces dermatitidis)、砂眼衣原体(Chlamydia trachomatis)和白色假丝酵母(Candida albicans)
除了上述之外，本发明的方法可以用于靶向寄生虫，诸如细胞内寄生虫和专性细胞内寄生虫。寄生虫的例子包括、但不限于恶性疟原虫(Plasmodium falciparum)、卵形疟原虫(Plasmodium ovale)、三日疟原虫(Plasmodiummalariae)、间日疟原虫(Plasmdodiumvivax)、诺氏疟原虫(Plasmodium knowlesi)、果氏巴贝虫(Babesia microti)、分歧巴贝虫(Babesia divergens)、克氏锥虫(Trypanosoma cruzi)、刚地弓形虫(Toxoplasmagondii)、旋毛形线虫(Trichinella spiralis)、硕大利什曼原虫(Leishmania major)、杜氏利什曼原虫(Leishmania donovani)、巴西利什曼原虫(Leishmania braziliensis)、热带利什曼原虫(Leishmania tropica)、冈比亚锥虫(Trypanosoma gambiense)、罗德西亚锥虫(Trypanosoma rhodesiense)、班氏吴策线虫(Wuchereria bancrofti)、马来布鲁线虫(Brugia malayi)、帝汶布鲁线虫(Brugia timori)、人蛔虫(Ascaris lumbricoides)、旋盘尾丝虫(Onchocerca volvulus)和曼森血吸虫(Schistosoma mansoni)。
如果经修饰，诱导的pDC可以用于诱导对一种或多种靶抗原的致耐受性应答，包括未来或现有的免疫应答的抑制。因此，诱导的pDC可用于治疗或预防不期望的免疫应答，包括例如移植排斥、移植物抗宿主病、变态反应、寄生虫疾病、炎性疾病和自身免疫性疾病。可以根据本发明治疗或预防的移植排斥的例子包括与骨髓和器官(诸如心脏、肝、胰腺、肾、肺、眼、皮肤等)的移植相关的排斥。变态反应的例子包括季节性呼吸变态反应；对气源性变应原的变态反应诸如花粉热；通过减少血清IgE可治疗的变态反应和嗜酸性粒细胞增多症；哮喘；湿疹；动物变态反应、食物变态反应；胶乳变态反应；皮炎；或通过变应性脱敏可治疗的变态反应。可以通过本发明治疗或预防的自身免疫性疾病包括例如银屑病、系统性红斑狼疮、重症肌无力、僵人综合征、甲状腺炎、西德纳姆舞蹈病、类风湿性关节炎、糖尿病和多发性硬化。炎性疾病的例子包括克罗恩氏病、慢性炎性眼疾病、慢性炎性肺疾病和慢性炎性肝疾病、自身免疫性溶血性贫血、特发性白细胞减少症、溃疡性结肠炎、皮肌炎、硬皮病、混合性结缔组织病、肠易激综合征、系统性红斑狼疮(SLE)、多发性硬化、重症肌无力、Guillan-Barre综合征(抗磷脂综合征)、原发性粘液性水肿、甲状腺毒症、恶性贫血、自身免疫性萎缩性胃炎、阿狄森氏病、胰岛素依赖型糖尿病(IDDM)、古德帕斯彻氏综合征、贝赫切特综合征、舍格伦综合征、类风湿性关节炎、交感性眼炎、桥本氏病/甲状腺功能减退症、乳糜泻/疱疹样皮炎和脱髓鞘病、原发性胆汁性肝硬化、混合性结缔组织病、慢性活动性肝炎、格雷夫斯病/甲状腺机能亢进、硬皮病、慢性特发性血小板减少性紫癜、糖尿病性神经病和脓毒性休克。
药学上可接受的载体和稀释剂包括盐水、缓冲水溶液、溶剂和/或分散介质。这样的载体和稀释剂的应用是本领域众所周知的。溶液优选地是无菌的和流体。优选地，在引入细胞之前，溶液在制造和储存条件下是稳定的，并且通过使用例如对羟基苯甲酸酯、三氯叔丁醇、苯酚、抗坏血酸、硫柳汞等针对微生物诸如细菌和真菌的污染作用进行防腐。
优选的是，细胞施用模式是相对非侵袭性的，例如通过静脉内注射、通过吸入的肺部递送、局部或鼻内施用。但是，细胞施用途径将取决于待治疗的组织，并且可能包括植入。用于细胞递送的方法是本领域技术人员已知的，并且可以由医学领域的技术人员外推以与本文所述的方法和组合物一起使用。
在一些方面，本文还提供了用于制备诱导的pDC的试剂盒，所述试剂盒包含本文描述的含有一种或多种表达载体组分的任何pDC诱导组合物。
在一些方面，本文还提供了包含本文所述的一种或多种pDC诱导因子作为组分的试剂盒，其用于本文描述的制造诱导的pDC的方法。
因此，在一些方面，本文提供了用于制备诱导的树突细胞的试剂盒，其包含以下组分：(a)一种或多种表达载体，其编码至少1、2、3、4、5、6、7、8种或更多种选自以下的pDC诱导因子：IRF8(SEQ.ID.1,SEQ.ID.2)、SPIB(SEQ.ID.3,SEQ.ID.4)、ARID5A(SEQ.ID.5,SEQ.ID.6)、BCL11A(SEQ.ID.7,SEQ.ID.8)、CBFA2T3(SEQ.ID.9,SEQ.ID.10)、CREB3L2(SEQ.ID.11,SEQ.ID.12)、ETS1(SEQ.ID.13,SEQ.ID.14)、HDAC5(SEQ.ID.15,SEQ.ID.16)、HHEX(SEQ.ID.17,SEQ.ID.18)、HOXA5(SEQ.ID.19,SEQ.ID.20)、ID3(SEQ.ID.21,SEQ.ID.22)、IKZF1(SEQ.ID.23,SEQ.ID.24)、IKZF2(SEQ.ID.25,SEQ.ID.26)、IKZF3(SEQ.ID.27,SEQ.ID.28)、IKZF5(SEQ.ID.29,SEQ.ID.30)、IRF7(SEQ.ID.31,SEQ.ID.32)、MEF2C(SEQ.ID.33,SEQ.ID.34)、MYB(SEQ.ID.35,SEQ.ID.36)、RUNX2(SEQ.ID.37,SEQ.ID.38)、STAT3(SEQ.ID.39,SEQ.ID.40)、TCF4(SEQ.ID.41,SEQ.ID.42)、TCF12(SEQ.ID.43,SEQ.ID.44)、STAT1(SEQ.ID.45,SEQ.ID.46)、TSC22D1(SEQ.ID.47,SEQ.ID.48)，和(b)其包装和说明书。
在一些实施方案中，本文所述的试剂盒可以进一步提供合成的mRNA或一种或多种编码pDC诱导因子的表达载体，其呈混合物或作为单独等分试样。
在一些实施方案中，所述试剂盒可以进一步包含增强重新程序化效率的试剂。在一些实施方案中，所述试剂盒可以进一步包含一种或多种抗体或引物试剂以检测细胞类型特异性标志物以鉴定被诱导到pDC状态的细胞。
在一些实施方案中，所述试剂盒可以进一步包含缓冲液。在一些这样的实施方案中，所述缓冲液是pH 7.0的无RNA酶的TE缓冲液。在一些实施方案中，所述试剂盒进一步包含含有细胞培养基的容器。
本文描述的所有试剂盒可以进一步包含缓冲液、细胞培养基、转导或转染培养基和/或培养基补充剂。在优选的实施方案中，所述缓冲液、细胞培养基、转染培养基和/或培养基补充剂不含DNA酶和RNA酶。在一些实施方案中，在所述试剂盒中提供的合成的、修饰的RNA可以呈特定量或质量(例如，20μg)的非溶液形式，诸如低压冻干的粉末形式，使得最终用户添加合适量的缓冲液或培养基以使组分达到期望的浓度，例如，100ng/μl。
本文描述的所有试剂盒可以进一步包含装置以促进使用本文描述的试剂盒组分生成的细胞的单次施用或重复或频繁输注，诸如不可植入的递送装置，例如，针头、注射器、笔式装置，或可植入递送装置，例如，泵、半永久性支架(例如，静脉内、腹膜内、脑池内或囊内)或蓄池。在一些这样的实施方案中，所述递送装置可以包括机构以分配单位剂量的包含诱导的pDC的药物组合物。在一些实施方案中，所述装置连续地释放组合物，例如，通过扩散。在一些实施方案中，所述装置可以包括监测受试者体内的参数的传感器。例如，所述装置可以包括例如泵和任选的相关电子元件。
在一个实施方案中，通过例如修饰体细胞、多能细胞、祖细胞或干细胞的至少一种本文所公开因子的基因表达，或通过使这些细胞类型中的任一种暴露于至少一种蛋白或产生至少一种如本文所公开蛋白的RNA，人工制造诱导的pDC。可以进一步通过使其暴露于开启至少一种本文所公开因子的小分子来制造所述细胞。在一些方面，使用至少2、3、4、5、6、7或8种因子来制造诱导的pDC。
在一个实施方案中，Clec9a、Tlr7、Tlr9和候选TF在DC子集和其它髓样细胞(单核细胞、巨噬细胞和小胶质细胞)中的表达数据获得自Immgen数据库(www.immgen.org)。通过cluster 3.0(对数转换数据；居中基因；居中、聚集和标准化细胞类型)分析表达数据，并通过Treeview显示。可替换地，使用GraphPad Prism展现表达值。
在一个实施方案中，以如下方式分离并纯化小鼠胚胎成纤维细胞(MEF)：使Clec9aCre/Cre动物(10)与Rosa26-stopflox-tdTomato报告物小鼠(The JacksonLaboratory)杂交以生成双重纯合的Clec9aCre/Cre RosatdTomato/tdTomato(Clec9A-tdTomato)小鼠。将所有动物圈养在受控温度(23±2℃)下，经历固定的12-h光照/黑暗周期，自由获得食物和水。
在一个实施方案中，从Clec9A-tdTomato或C57BL/6小鼠的E13.5胚胎分离MEF的原代培养物(6,10)。移除头、胎儿肝脏和所有内部器官，并将剩余组织机械解离。将解剖的组织使用0.12％胰蛋白酶/0.1mM乙二胺四乙酸(EDTA)溶液(3mL/胚胎)进行酶消化，并在37℃温育15min。每个胚胎另外添加3mL相同溶液，随后是另外15min温育时段。获得单细胞悬浮液并铺板于0.1％明胶包被的10-cm组织培养皿中的生长培养基中。使细胞生长2-3天直到汇合为止，用Tryple Express解离并在胎牛血清(FBS)+10％二甲亚砜(DMSO)中冷冻。在铺板用于慢病毒转导之前，分选MEF以移除残留的CD45+和tdTomato+细胞，其可以代表具有造血潜力的细胞。
在一个实施方案中，将HEK293T细胞和MEF维持在生长培养基[补充有10％(v/v)FBS、2mM L-谷氨酰胺和抗生素(10μg/ml青霉素和链霉素)的Dulbecco氏改良的伊格尔培养基(DMEM)]中。将所有细胞维持在37℃和5％(v/v)CO2下。除非另有说明，否则所有组织培养试剂均来自Thermo Fisher Scientific。
在一个实施方案中，以如下方式进行病毒转导和重新程序化实验：将Clec9A-tdTomato MEF以40,000个细胞/孔的密度接种于0.1％明胶包被的6-孔平板上。将细胞以1:1FUW-TetO-TF和FUW-M2rtTA慢病毒颗粒的比率在补充有8μg/mL聚凝胺的生长培养基中温育过夜。在测试TF的组合时，应用相等MOI的每种单独病毒颗粒。将细胞在连续几天中转导两次，并且在过夜温育后，用新鲜的生长培养基更换培养基。在第二次转导后，向生长培养基中补充多西环素(1μg/mL)-第0天。每2-3天更换培养基，持续培养的持续时间。在转导后5-8天分析新出现的tdTomato+细胞。
在一个实施方案中，以如下方式进行流式细胞计量术分析：将转导的Clec9A-tdTomato MEF用TrypLE Express解离，重新悬浮于200μL PBS 5％FBS中并保持在4℃，然后在BD FACS LSR II(BD Biosciences)中进行分析。为了分析MHC-II细胞表面标志物表达，将解离的细胞与在PBS 5％FBS中稀释的APC-缀合的大鼠抗-小鼠I-A/I-E抗体(Biolegend)或APC-Cy7-缀合的抗-CD45抗体(Biolegend)一起在阻断非特异性结合的大鼠血清(1/100,GeneTex)存在的情况下在4℃温育30分钟。将细胞用PBS 5％FBS洗涤，重新悬浮于PBS 5％FBS中并在BD FACS LSR II中进行分析。使用FlowJo软件(FLOWJO,LLC，版本7.6)分析流式细胞计量术数据。
在一个实施方案中，以如下方式进行荧光激活细胞分选术(FACS)：为了纯化Clec9A-tdTomato MEF，将细胞与在PBS 5％FBS中稀释的APC-Cy7-缀合的抗-CD45抗体(Biolegend)一起在4℃温育30分钟。随后，将MEF用PBS 5％FBS洗涤，重新悬浮在PBS 5％FBS中，并将tdTomato-CD45-MEF在BD FACSAria III中纯化。当描述时，使用BD FACSAriaIII纯化tdTomato+细胞。在FlowJo软件中处理FACS数据。
在一个实施方案中，使用2个无菌载玻片的磨砂末端对来自Clec9a-tdTomato小鼠的新鲜分离的脾进行匀浆化。将细胞收获在补充有5％FBS的PBS中，并通过70μm细胞过滤网(BD Biosciences)过滤。将红血细胞在室温下用BD Pharm Lyse(BD Biosciences)裂解8分钟。通过添加≥5个体积的PBS 5％FBS来停止裂解。将脾细胞洗涤一次以获得单细胞悬浮液，将其与在PBS 5％FBS中稀释的FITC-缀合的抗-CD11c抗体(Biolegend)、APC-缀合的抗-Bst2抗体(Biolegend)、APC-Cy7-缀合的抗-B220抗体(Biolegend)和BV605-缀合的抗-Siglec-H抗体(Biolegend)的混合物一起在大鼠血清存在的情况下在4℃温育30分钟。包括单染色和荧光减一对照以进行适当的补偿和门控。在4℃保持30分钟后，将细胞洗涤并用PBS 3％FBS重新悬浮，并在BD FACSAria III(BDiosciences)中进行分析。使用FlowJo软件处理由此分析产生的数据。脾pDC被鉴定为活单细胞CD11c低Bst2+B220+Siglec-H+。
在一个实施方案中，以如下方式进行炎性细胞因子测定：将tdTomato+细胞在第9天进行FACS分选，并与1μg/mL R848(Invivogen)和0.5μM CpG ODN 1668(Invivogen)一起培养以分别进行TLR 7和TLR9过夜刺激。在第10天评估细胞因子干扰素-α(IFN-α)、干扰素-β(IFN-β)、白介素-10(IL-10)、白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、C-C基序趋化因子配体5(CCL5)和C-X-C基序趋化因子配体10(CXCL10)的水平。收集50μL来自96孔板孔的培养物上清液，并根据生产商的说明书通过带有V板的LEGENDplexTMMouse Anti-VirusResponse Panel(13-plex)(Biolegend)进行分析。使用BD FACS LSR II进行采集，并使用LEGENDplexTMData Analysis 8.0版(Biolegend)分析数据。
本领域技术人员将认识到或仅仅使用例行实验就能够确定许多与本文所述的本发明的具体实施方案等效的方案。本发明的范围无意限于上面的描述，而是如所附权利要求所述。
如果没有特别排除，当在权利要求的说明书中使用单数形式的要素或特征时，也包括复数形式，反之亦然。例如，术语“一种转录因子”或“所述转录因子”还包括复数形式的“多种转录因子”或“所述转录因子”，反之亦然。在权利要求中，冠词诸如“一个/种(a)”、“一个/种(an)”和“所述”可以是指一个/种或超过一个/种，除非指示相反情形或以其它方式从上下文显而易见。如果组成员中的一个、超过一个或所有成员存在于给定的产品或过程中、在给定的产品或过程中使用、或以其它方式与给定的产品或过程相关，则认为满足了在一组的一个或多个成员之间包括“或”的权利要求或描述，除非指示相反情形或以其它方式从上下文显而易见。本发明包括这样的实施方案，其中所述组的刚好一个成员存在于给定产品或方法中、用于给定产品或方法中或者以其它方式与给定产品或方法相关。本发明还包括这样的实施方案，其中所述组成员中的超过一个或全部都存在于给定产品或方法中、用于给定产品或方法中或者以其它方式与给定产品或方法相关。
此外，应当理解，本发明涵盖所有变体、组合和排列，其中将来自一项或多项权利要求或来自说明书的相关部分的一个或多个限制、要素、条款、描述性术语等引入另一项权利要求中。例如，从属于另一项权利要求的任何权利要求可以修改为包括在从属于同一基本权利要求的任何其它权利要求中发现的一个或多个限制。
此外，当权利要求叙述一种组合物时，应当理解，包括为了本文中公开的任何目的而使用所述组合物的方法，并且包括根据本文中公开的任意制备方法来制备所述组合物的方法或本领域已知的其它方法，除非另外指出或除非本领域的普通技术人员明白会出现矛盾或不一致。
在给出范围的情况下，包括端点。此外，应当理解，除非另外指出或以其它方式从上下文和/或本领域普通技术人员的理解显而易见，否则被表达为范围的值可以采用在本发明的不同实施方案中的所述范围内的任何具体值，其精确至该范围的下限单位的十分之一，除非上下文另外清楚地指明。还应当理解，除非另外指出或以其它方式从上下文和/或本领域普通技术人员的理解显而易见，否则被表达为范围的值可以采用在给定范围内的任何子范围，其中将所述子范围的端点表达至与所述范围的下限单位的1/10相同的精确度。
本公开内容不应以任何方式被视为限于所描述的实施方案，并且本领域普通技术人员将预见到对其修改的许多可能性。
上述实施方案是可组合的。
下表提供了在本公开内容中包括的序列的概述。
表1.在本公开内容中包括的SEQ.ID.
Figure BDA0003647639210000471
Figure BDA0003647639210000481
Figure BDA0003647639210000491
以下权利要求进一步阐述了本公开内容的特定实施方案。
序列表
<110> 阿斯加德治疗有限公司
<120> 用于将细胞重新程序化成浆细胞样树突细胞或I型干扰素产生细胞的组合物、方法及其用途
<130> P5666PC00
<160> 96
<170> PatentIn 3.5版
<210> 1
<211> 2669
<212> DNA
<213> 智人
<400> 1
gtgaggtcat ggaggccagc attgccttct catggcaggt gtcccggagt ccctgaatct 60
gatgtgtgac cggaatggtg gtcggcggct tcgacagtgg ctgatcgagc agattgacag 120
tagcatgtat ccaggactga tttgggagaa tgaggagaag agcatgttcc ggatcccttg 180
gaaacacgct ggcaagcaag attataatca ggaagtggat gcctccattt ttaaggcctg 240
ggcagttttt aaagggaagt ttaaagaagg ggacaaagct gaaccagcca cttggaagac 300
gaggttacgc tgtgctttga ataagagccc agattttgag gaagtgacgg accggtccca 360
actggacatt tccgagccat acaaagttta ccgaattgtt cctgaggaag agcaaaaatg 420
caaactaggc gtggcaactg ctggctgcgt gaatgaagtt acagagatgg agtgcggtcg 480
ctctgaaatc gacgagctga tcaaggagcc ttctgtggac gattacatgg ggatgatcaa 540
aaggagccct tccccgccgg aggcctgtcg gagtcagctc cttccagact ggtgggcgca 600
gcagcccagc acaggcgtgc cgctggtgac ggggtacacc acctacgacg cgcaccattc 660
agcattctcc cagatggtga tcagcttcta ctatgggggc aagctggtgg gccaggccac 720
caccacctgc cccgagggct gccgcctgtc cctgagccag cctgggctgc ccggcaccaa 780
gctgtatggg cccgagggcc tggagctggt gcgcttcccg ccggccgacg ccatccccag 840
cgagcgacag aggcaggtga cgcggaagct gttcgggcac ctggagcgcg gggtgctgct 900
gcacagcagc cggcagggcg tgttcgtcaa gcggctgtgc cagggccgcg tgttctgcag 960
cggcaacgcc gtggtgtgca aaggcaggcc caacaagctg gagcgtgatg aggtggtcca 1020
ggtcttcgac accagccagt tcttccgaga gctgcagcag ttctataaca gccagggccg 1080
gcttcctgac ggcagggtgg tgctgtgctt tggggaagag tttccggata tggccccctt 1140
gcgctccaaa ctcattctcg tgcagattga gcagctgtat gtccggcaac tggcagaaga 1200
ggctgggaag agctgtggag ccggctctgt gatgcaggcc cccgaggagc cgccgccaga 1260
ccaggtcttc cggatgtttc cagatatttg tgcctcacac cagagatcat ttttcagaga 1320
aaaccaacag atcaccgtct aagtgcgtcg cttgggcgcc ccaccccgtc tgcgtcctgc 1380
atccatctcc ctgttacagt ggcccgcatc atgattaaag aatgtggatc cctctgtctg 1440
gggtgggatg ccttactttg cacttaattt aataagggca ttctcggagg agtagacgtt 1500
taatacgaag tggcggcata gccctgccga gatgtcggtg atggcctgga tgctgtaacc 1560
acaacctgtg gctaaaaatt ttattttcta tcctttaccc gtcattatca ttagttgcta 1620
tgattctttc tgcattttcg gttaactatc atttccaaag acttgtcatt cagtaatatt 1680
agcagatagc tgcttcgata aaggaatttg gagtttaaaa atcaacttgt gaaaacaagg 1740
ttgtttttgt ctttatcgtt tgttagagtt atagatttat gatttcatag gcttgattct 1800
atgtgaaata tctttttact tttatgcatt ttaataagat ttaaaaatat ttagattaaa 1860
gcccccttta atgagtacaa gaaaaactct tggcttgtta gaagaaagta tattctttct 1920
agaatttggt gcaggaatat gtgttcatat ccaggcaaac gggtgtgttt ttatcttcag 1980
acaatgaaac cttctcctct ggggctttgt tgccaggaag attagaacta aatttatttt 2040
tttcatttct gtcatgaaat cattccagat acctcttttc ttctttccaa atggttttca 2100
catgtgtttg aaatatttgt acttcgaatt gtcggatttt ccatgtcctc ctttctcctt 2160
tgtgcccagc ctgagtcagc accaatcccg cattcagaac ctcccagtga aagggcagcc 2220
ttcattttga gaaggtggaa ggtgttaggg tttgggagac agctcatcca atctcccaag 2280
tctcatggtg gatttgtgac tgtgagagtt tccggtttaa aatctgaaaa gccagatatg 2340
cctgtttcct tttcccagca ccatgcctgt ggaggggaca gtcagaccca gaggtccttt 2400
acgtgtggat ggagttcaca ggcgaataga ggagaggacc aggggacgtg gcttgtccct 2460
tttgtccaac aaagcattat atttttaaga atggcagacc tgtttgctga agtgttcata 2520
agataacaat aggcttgaat ctccaattca aatgaatgtc aaagcacata tctttaatat 2580
gctgaatgaa tatttatttt tgtatccatt aaaacagtat attgatctct tttattcttt 2640
attaaaataa aatgctcttt tttaaagct 2669
<210> 2
<211> 3391
<212> DNA
<213> 小家鼠
<400> 2
ttccaagccc actggtggca gttagggctg ctgtgtggct aaaaccagcc ctggagagac 60
ctcatctccc tcctctcagg ctgctgccgt ctttcctggc cccactacca cctgcaagcg 120
gcctggagtt tctgaccctc aggcctcttt ccagcaatcc tgactttgtg ggacatgctg 180
gctctggatg tgactatgtt cttggggata tcttgacttc tcactgatga taacttcttt 240
tttttttttt tttccctacc ccaagaggtc attttagttg gaagactaga agtgctgtgt 300
tctggttttc agggtgggcg tctgtccaac tgctttgggg atttccaggc tgttctagta 360
aatgctggct gcaagtccct gtgcacaaat gccctctctc cccacgctgt aggaaaagca 420
gacccgagag tgtccaagtg tgccattagg tgtctgggga tggcgggcct ggatatggag 480
tccctgagct ggctttgtac tgtccctttg ttctcactga gggctgattg taagagggac 540
tccctgtgtt gttggaggag tcctctagga tacaggctct gattgcagga tgtgtgaccg 600
gaacggcggg cggcggctgc ggcagtggct gatcgaacag atcgacagca gcatgtaccc 660
ggggctgatc tgggaaaatg atgagaagac catgttccgt atcccctgga agcatgccgg 720
caagcaggat tacaatcagg aggtggatgc ttccatcttc aaggcctggg cagtttttaa 780
agggaagttt aaagagggag acaaagctga accagccacg tggaagacga ggttacgctg 840
tgctctgaac aagagcccag attttgaaga agtgactgac cggtcccagc tggacatttc 900
tgagccatat aaagtttacc gaattgtccc cgaggaagaa caaaaatgca agctgggcgt 960
ggcacctgca ggctgcatga gcgaagttcc tgagatggag tgtggccgct cagagattga 1020
ggagctgatc aaggaacctt ctgtggatga gtacatgggt atgaccaaga ggagcccatc 1080
cccaccagag gcctgcagga gccagatcct ccctgactgg tgggtccagc agcccagtgc 1140
aggcctgcca ctggtgaccg gatatgccgc ctatgacaca caccattcag ctttctccca 1200
gatggtcatc agcttctact acgggggcaa gctggtgggc caggccacca ccacctgcct 1260
tgaaggctgc cgtctctccc tgagccagcc ggggctgcct aagttgtatg ggccggatgg 1320
cctggaaccc gtgtgctttc cgacggccga caccatcccc agtgagcggc agaggcaggt 1380
gacccggaag ctgtttgggc acctggaacg tggcgtgcta ctgcacagca accgcaaggg 1440
cgtgttcgtg aagcggctgt gccagggccg cgtgttctgc agcggcaacg cggtggtgtg 1500
caagggcagg cccaacaagc tggagcggga cgaggtggtg caggtctttg acaccaacca 1560
gttcatccga gagctgcagc aattctacgc cacccagagc cgcctacctg acagcagggt 1620
ggtcctgtgc ttcggggagg agtttccgga cactgtgccc ttgcgctcca aactcattct 1680
ggtgcaggta gagcagctgt atgccaggca gctggtggag gaagcgggca agagctgcgg 1740
tgctggctcc ctgatgccag ccctggagga gccccagccg gaccaggctt tccgcatgtt 1800
tccggatatc tgtacctcac accagagacc cttttttaga gaaaatcaac agatcaccgt 1860
ctaagcctca gtccgggcac cccacctcgc ctgagctcaa gcttcaagag tctgtgacta 1920
agagaattcc gaaaggatgt ggagccctct gactggggtg ggcgggtgtc ctccaagggg 1980
cctccggaag cccacagagg gatgcgctcc tgctcaggca ggtgtcagaa gcttgcaggg 2040
gctgtggccg caacctgtga ttaaagcatt cctttcctgc gtttccccct tcaccactaa 2100
tggctggcct ttctgtgtgc tgaggtcttt cgacagttca aatcatctgg tggcagcaga 2160
ctcgcctttg cccttctgcg gccgagggcg gagatttatg actttctctg cttggttgga 2220
gaagaagaat ctttactatt cagcttcttt tctttttggc cagaactctg aaaaaaaaaa 2280
aaactctttt taagacaata tttgtattct cacaggctca gctgtcaatc acttgagacc 2340
ttccctgtaa agtggggcag attttaaata tgggtgtaga tactgcttgc agccttcgca 2400
ggaattttgg ttgtggttca ttgattcaca cagactctgt gtcagctgac agggctgtgt 2460
ggggcatcaa aggaggacca ggcactgtgg agaagaccca ttcactggca tctcaccctt 2520
ccttgtccag ctccataccc agtcctaaga cccagtgaaa agccacgtcc aaactgtgct 2580
ctgggctcat cagtgcccac ccacgtacca gggaaaggca cacaccctac ccagtgggca 2640
cagagcggaa tgtcccccta ccgcaccatt tgcgccccca atctggctgt ccaacctagt 2700
ttgtaagtaa tctaaatcag tgactatagc cccgcctaag ggacacttcc cggaggaggg 2760
agccgctgaa aaggagttag tttgagggtc agtacacaac aggggcagaa agccaagcag 2820
atgtgggggc agggagagtc atcatctgct tttgtctgag agaaggagag cttctccgtt 2880
tgttcaactt tgtaacaagc tgggttacat gctccacgca gctagagaag cctaggtgct 2940
ctgcattccc tggggaactg caggaaagcc ttacctgctg actgttgctc tggggaaaag 3000
cctgagggtc cagagcagct acaagctaca ggccatacct tacaacctga aaagctaagg 3060
accacggtga ccttcccggc tactgtgtga aggtgctggg tggggcctgc tcaacagaca 3120
gggtcgacag agtgtgtgat acatgcaaac agaatccttg gagtgtgtga tacatgcaaa 3180
cagaatcctg ggcccctgct tctccccctc agtcaaagca ggagtgtccc ttccgaagcc 3240
aggacaacct gttcacaagg ccccttgtca catgtcacct tccacctgcc tcaaggagtg 3300
ctagtgtcca aatatttatt tttgtattct cttaagaagt attgatttca tcctttatta 3360
aaaaaagttg ctctttcaca aaaaaaaaaa a 3391
<210> 3
<211> 3792
<212> DNA
<213> 智人
<400> 3
ggcaaacagc ccgcccggca ccaccatgct cgccctggag gctgcacagc tcgacgggcc 60
acacttcagc tgtctgtacc cagatggcgt cttctatgac ctggacagct gcaagcattc 120
cagctaccct gattcagagg gggctcctga ctccctgtgg gactggactg tggccccacc 180
tgtcccagcc accccctatg aagccttcga cccggcagca gccgctttta gccaccccca 240
ggctgcccag ctctgctacg aaccccccac ctacagccct gcagggaacc tcgaactggc 300
ccccagcctg gaggccccgg ggcctggcct ccctgcatac cccacggaga acttcgctag 360
ccagaccctg gttcccccgg catatgcccc gtaccccagc cctgtgctat cagaggagga 420
agacttaccg ttggacagcc ctgccctgga ggtctcggac agcgagtcgg atgaggccct 480
cgtggctggc cccgagggga agggatccga ggcagggact cgcaagaagc tgcgcctgta 540
ccagttcctg ctggggctac tgacgcgcgg ggacatgcgt gagtgcgtgt ggtgggtgga 600
gccaggcgcc ggcgtcttcc agttctcctc caagcacaag gaactcctgg cgcgccgctg 660
gggccagcag aaggggaacc gcaagcgcat gacctaccag aagctggcgc gcgccctccg 720
aaactacgcc aagaccggcg agatccgcaa ggtcaagcgc aagctcacct accagttcga 780
cagcgcgctg ctgcctgcag tccgccgggc ctgagcacac ccgaggctcc cacctgcgga 840
gccgctgggg gacctcacgt cccagccagg atccccctgg aagaaaaagg gcgtccccac 900
actctaggtg ataggactta cgcatcccca ccttttgggg taaggggagt gctgccctgc 960
cataatcccc aagcccagcc cgggcctgtc tgggattccc cacttgtgcc tggggtcctc 1020
tgggatttct ttgtcatgta cagactccct gggatcctca tgttttgggt gacaggacct 1080
atggaccact atactcgggg aggcagggta gcagttcttc cagaatccca agagcttctc 1140
tgggattttc ttgtgatatc tgattcccca gtgaggcctg ggacgttttt aagatcgctg 1200
tgtgtctgta aaccctgaat ctcatctggg gtgggggccc tgctggcaac cctgagccct 1260
gtccaaggtt ccctcttgtc agatctgaga tttcctagtt atgtctgggg ccctctggga 1320
gctgttatca tctcagatct cttcgcccat ctatggctgt gttgtcacat ctgtcccctc 1380
atttttgaga tcccccaatt ctctggaact attctgctgc ccctttttat gtgtctggag 1440
ttccccaatc acatctaggg ctcctccaag atccttttgt catgtctgaa atcactcttg 1500
agaggtctgg ggtggaggat ggggagtcag tgaaatgtgt catgtctggg ccctgtcagg 1560
gacacccttg ttatatctgg gatcctccaa tcacatctga gacctcctag gctctccatc 1620
tgatatgccc tttcagggac cccacaaaga ctgagttctc atggggatcc tacccttcct 1680
agtgccactc cctatggcca tgctgaagac cactctggcc acgcgactga ttttgggtga 1740
tcatggcagc tccccaccca tgtcatttct aaccagaagt ctcaaggtcg tcacccccct 1800
gccccccaac cgaggccccg gtcgctggtg gtggtctctt tagtgcactg tagcacttgg 1860
tggtggaggt gtgagggatc cacattaaca gcaggccatc agctgggcaa tggctcacac 1920
ctgtaatccc agcactttgg gaggcgaggc agggggaatg gcttgaaccc aggcattcaa 1980
gaccagcctg ggcaacataa tgagacctcg tctctacaaa acataacaaa aacaattagc 2040
cgagcgtggg ggtgaacacc tgtggtccca gctgctcagg aggctgaggt gggaggatct 2100
cttgagccca ggaagtagga ggctgtagtg agctgtaatc gtgccactgc actccagcct 2160
gggcgacaga gtgagacacc gtcttaaaaa caaaaacaag gccgggcacg gtggctcatg 2220
cctgttgtcc cagcactttg ggaggccgag gcaggcggat cacgaggtcg agagatcgag 2280
accatcctgg ccaacatggt gaaaccctgt ctctactaaa aatacagaaa ttagctgggc 2340
gtggtggcac gtgcctgtag tcccagctac tcgggaggct gaggcaagag aatcgcttga 2400
acgtgggagg cagaggttgc agtgagccta gattgtgcca ctgcactcca gcctggggga 2460
cagagcgaga ctccgtctga aaataaaaac aacaaaaaca gcagaccatt caaaataggg 2520
agactttgca taatccagat ttctgccttc acttaaaact ttggacggtc tggagagagt 2580
cggccagttt tcggtggggg gtggggagct ggaacaggac agtagccttt cctaatgagg 2640
catttgttct ccaatctgcc ccagtcgctg ccatccctgg ctatctcacc ctagcagctt 2700
ctcaagcctg ttggctttag accactgtat aaacccagct ggaactgaag cctgggtgga 2760
ctatggagcc ctggttggga cccccaggga gtcaaaggct gcgggccaag aggccagagg 2820
tccttgagcc tgggtgggca ggtggatcta gggtgcatga cttgctgctt cccaacctta 2880
gtttgtccct tctgtgaaaa agggagagaa ggaggaggaa gatctcaaaa agactttcca 2940
gcccagtgcg gtggctcacg cctgtaatcc cagcactttg ggaggccgat gcaggtggat 3000
cacctgaggt aggagttcaa gaccagcctg accaacatag tgaagcccct tctctactaa 3060
aaatacaaaa ttagctgggc gtggtggcat gtgcctgtac tcccagctac ttgggaggct 3120
gaggcaggag aatcgcttga acctgggagg cggaggttgt agtgagctga gatcacacca 3180
ctgcacacca gcctgggcga caagagcgaa actccgtctc aaaaaaaaaa aactgttgca 3240
gccccgttga gcctttgaca ccgcctgaaa tccaccccac tcccaggagg aggaggagga 3300
aggaatgcca atgacctaga gacacgagaa gtccatgtgg aggcacacag cagctgatgg 3360
cagagcccag gctgggacct gcccttaaga gaatgagtgg gaagggggag ggaggaaggg 3420
caggtaaaac gtcctcccca gggccccctg caacggggaa ggtacttttt acaaaagcta 3480
tcattgtcac cctaaatgtg gaataaaata agatgcatcg acgtagacaa acctcctggg 3540
accttttgtc agggactgca atcctgcccc tccactgagg ccgctggctc tcagagacac 3600
cgtgacatca cgggtgatga tgagaggagt tcaaagagag aattatatgc tggcgcggtg 3660
gctctgtaat cccaacactt tggggggcca aggcaggagg atcgcttgag tacaggagtt 3720
tgaaaccagc ctgggcaaga tagtgagatc cccttcccac ccgtctacaa aaaaaataaa 3780
aaattagcgg gg 3792
<210> 4
<211> 2786
<212> DNA
<213> 小家鼠
<400> 4
agcctgctct gaaccaccat gcttgctctg gaggctgcac agctggatgg cccacactta 60
agctgtttgt acccagaagg agtcttctac gacctggaca gctgcaagcc cttcagttac 120
ccagattcag atgggggcct tgactctaca tggggctgga cagaggcccc gcctgctcct 180
gccatcgctc cctatgaagc cttcgatcct gctactgctg cctttagcca ctcccaaact 240
gttcagctct gttatagcca tggtcctaac ccctccacct atagccccat ggggaccctc 300
gacccagccc ccagcttgga ggccccaggg cctggcctcc aggtgtaccc cccagaggac 360
ttcaccagcc agaccctggg ctccttggct tatgctccgt accccagccc tgtgctatca 420
gaggaagaag acattatgct ggacagcccc gccctggagg tctcggacag tgagtcagac 480
gaggccctct tggctggctc cgaggggagg ggatctgagg caggtgcacg caagaagctg 540
cgcctgtacc agttcttgct ggggttgctc ctacgcgggg acatgcgcga gtgcgtgtgg 600
tgggtggagc caggtgccgg cgtcttccag ttctcctcca agcacaagga gttgttggct 660
cgccgctggg gccagcagaa gggcaaccgc aagcgcatga cgtatcagaa gctggcccga 720
gcgctgcgca actatgccaa gacaggcgaa atccgcaagg tcaaacgcaa actcacctac 780
cagtttgaca gcgcgctgct gccagcctcc cggcatgtct gagcactccg ctaaggaccc 840
ctttctggcc cctaagtccc atggagcccc atatgagggc agtcagggtt ctcagctctc 900
cctagagcct ccccagagtt tcctgtgccg tgtataggat tccaatctag gatggtcgtg 960
tttgagggag cactggccat tctacacggt ttcagaatgg caggtttctc gggggggggg 1020
gggatggggg agccctgatg tcgtctacgg ttccagaaac cgcagttctt gcgagtcctg 1080
tgagctcaca tgacatctca ccagcaggtg gcgctgtcta cagccccccc caaacccttg 1140
ttttgttggc cagataggtc ggtccctctg tactccccct gaagcccttg ttagatctga 1200
ggtctagtta tgtttggagc tctctgagaa ccctgtgcca cctgtgtgtg acttttctct 1260
gcgtccgttt atgacttttg tttgtttgag acagggtctc attatgtagc tcaggctggc 1320
cccccaactt ttaacaatcg tcctgcctcg gcctcctgag tgctgggatg acaagggtgc 1380
accatcacac caggtttttt ccttttttga gagattttac tatgtaaccc gggctgggct 1440
attctcaagc tagtggcagt cctcttgcct caggctcctc ttgcctcagg caccccttgg 1500
gaccctctgg gacctatgtc cgagatgaat ggctgggtaa ggtagggtgg gaggttcagt 1560
gaaccttata ggttgggccc ttccttctgg gatcccttga tcatatggga agttctctag 1620
gctctcagca gccctgcatt cacacactga ctgaggcgcg acctgtatgt tgtgtttgag 1680
ggggatgtgt ggcagaggta tggctgtggc aaggccggtg ccttttattc ttgagattga 1740
gtcttatgta gctcaggctg gtcttgaact cactctcact gtgtagctag ggaagacctt 1800
gagcccttgc ctcagccaga atgctcagat gtcaggcagc gcaccacgtg actgtttctt 1860
tccattgtct tgtctttttg ttgttgttgt tttcgagaca gggtttctct gtgtagccct 1920
ggccgttctg gaactcactc tgtagaccag gctggcctta aactcagaaa tccacctgcc 1980
tctgcctctc aaatgctggg attaaaggcg tgcaccacca cgcccttttt cctttttctt 2040
aagtcaaggt ctatttgtgt agcccaggct ggcttcaagc tcatgacact cttcctgcct 2100
ctgcgtctgg aactatgaac ataccttact actctgtgct tacccacgcc atgggtagac 2160
agacttctag acttggtcaa cccccaccca caaggcaggc aaattaagtc cctgcaggtg 2220
ctttctttgg aggaaagccc gctttcatag tgatctgtca agctagaaag cactcccgcc 2280
acccagatat ctaagtgtga atctttggac aactggtgac ttctggccag cttttctggg 2340
gccggcctct gtccaggtgt ctgcccagga ccctgctcag tgcctgtctg tctcacacca 2400
gtgacttcct cacacccgcc tgttcaggcc cagtcttttc cgttcaagtg ctacaggcca 2460
agtaggctca aactgtgggt ttgtcttggg catccacagc agaatcagaa cccagagctt 2520
tgaagcctga gtgaggggag gggggcactc aggcttccgt ctctctgaga aacagacgat 2580
gaagaggccc ttaaaactct ttgcaacccc atgagcctcc ccaatgagcc tgtgacacac 2640
cggaactcac ctctgtgggt ggccgggagg gggaacaggg tcatggaaga tccagatgtc 2700
catgtggtca aggctaaact gtactaaata aaattatttc tcatcaccac tatacatgca 2760
taataaataa agtgtacatc aaaatt 2786
<210> 5
<211> 2343
<212> DNA
<213> 智人
<400> 5
atctcagaga gcgcggggtc cggacagccg cgcgctgagg gtctcggggc gggcgccgcg 60
ggacctctcc gggccatggc agcccctgtc aaagggaaca ggaagcagtc cacggagggt 120
gacgccctag acccacctgc atcccccaaa cctgctggca agcagaacgg aatccagaac 180
cccatctcgc tggaggactc ccccgaggca ggcggggagc gggaggagga gcaggagcgg 240
gaggaggagc aggccttcct ggtcagcctc tacaagttca tgaaggagcg acacacgccc 300
atcgagaggg tgccccatct cggcttcaag cagattaacc tgtggaagat ctacaaagca 360
gtggagaagc tgggggccta tgagctgcag tccatggccc taggagagag aatcggctgg 420
ccgctgctgg agccgcagag cagctgccaa actgcagtcc ttcgagtccc tgcgagggcg 480
gccggagctg caaggacccc gccgccaggg ggcgcccgcc ggccgcgccc tcacgaggtg 540
cccttgcagg tgaccgggcg ccgcctctgg aagaacgtgt acgacgagct ggggggcagc 600
ccaggcagca ccagcgcggc cacgtgcacg cgccgccact acgagaggct ggtcctgcca 660
tacgtgcggc acctgaaggg ggaggatgac aagccgctgc ccacctccaa gcccaggaaa 720
cagtacaaga tggctaagga gaacaggggg gatgatgggg ccaccgagag gccgaagaag 780
gccaaggagg agcggcgcat ggaccagatg atgccaggaa agaccaaagc agatgctgct 840
gacccagcac cacttcccag ccaggagccc cccaggaaca gcacagaaca gcagggcctg 900
gcctctgggt cttctgtgtc ctttgtgggt gccagcggct gtcctgaggc ctacaagcgg 960
ctcctatcca gcttctactg caaggggaca cacggcatca tgtcaccact ggccaaaaag 1020
aagctcctgg cccaggtgag caaggtggag gccttgcagt gccaggagga gggctgccgc 1080
catggggcag agccccaggc gtccccagct gttcacctcc cagagagtcc ccagagcccc 1140
aaagggctga ctgagaactc caggcaccgg ctgacccctc aggagggatt gcaggcccca 1200
ggtggcagcc tcagagagga ggcgcaggca ggcccctgcc cggcagcccc catcttcaag 1260
ggctgcttct acacccaccc caccgaggtg ctgaagcctg tcagccagca ccccagggac 1320
ttcttctcta gacttaaaga tggggtgcta ttggggcctc ctggcaaaga ggggctgtca 1380
gtgaaagagc cccagctggt gtggggcgga gacgctaacc gcccttctgc gttccataaa 1440
ggtggctcca gaaagggcat cctctacccc aagcccaaag cctgctgggt gtcccccatg 1500
gccaaggtcc cagccgagag ccccacgctc ccgcccacct tccccagtag cccaggcctg 1560
ggcagcaagc gcagcctgga ggaagagggt gctgcccaca gtgggaagag actgcgggcc 1620
gtgtctccct ttcttaagga ggcggatgcc aagaagtgtg gggccaaacc tgcagggtcc 1680
ggcctggtct cctgccttct gggcccagcc ctggggcctg tgcccccaga ggcctacagg 1740
ggcaccatgc tgcactgccc gctgaacttc actggcaccc cgggcccctt gaagggccag 1800
gctgcactcc ccttcagccc cctggtcatc ccggccttcc cggcccactt cctggccacc 1860
gcaggcccct cgcccatggc cgctggcctg atgcacttcc ccccaacgtc cttcgacagt 1920
gccctccgcc acagactttg cccggcctca tctgcctggc acgcaccacc agtcacaacc 1980
tatgcagcgc cccacttctt ccacctcaac accaagctgt aggccagccc atggtgttgt 2040
gtacactgtg gagtcgacag gggcctacaa caggcaggta ctgctgccag ggggctctga 2100
actagtgcct gctacccagg acacccgggc catgcccctg gctgggcagc ctggcacaag 2160
tgaagaagaa ggcagtggga aaactgggtt tatctcaagg cagcagcctg agcccaggag 2220
cagaggaccc agttgttata aggcgctggg agaggatggg cagctcccac tgccccagag 2280
cggagctcga agcacccagg ttgcccacgg aaaatccaat aaaaagacac cagtgtgaat 2340
cca 2343
<210> 6
<211> 5699
<212> DNA
<213> 小家鼠
<400> 6
agtcgagcgg cgccggtagt cagtcgcgcc gagagcgctg ggacaggacg gctgtgcgtg 60
tagagggtct ctgcatagcg acgcgcgctc tcgctgggcc atggcagcac ctccggccaa 120
agggaacaca gagcagtcag aagaaggtga cctcccgcag cttcctgtat cccccaagcc 180
agatgatgag cagagcagga gccagagccc cacccagctc caggactccc ctgaggcagg 240
tggggagcag gaggaggaac aggccttcct ggtcagcctc tacaagttca tgaaggagcg 300
acacacgccc atcgagaggg tgccccatct tggcttcaag cagattaacc tgtggaagat 360
ctacaaggca gtggagaagc tgggggccta tgagctggtg acaggccgcc gcctctggaa 420
gaacgtgtat gatgaacttg gcggtagccc aggcagcacc agtgcggcca catgcacacg 480
ccgccactat gagaggctgg tcctcccata tgtgcggcat ctgaaggggg aggacgacaa 540
gccactgcct cctaccaagc ccaggaagca atacaagatg gccaaggagc tgaggggaga 600
cgatgggacc actgagaagc tgaagaaggc caaggactca gaggagaggc gggtggagca 660
gaccacgcca ggaaagacca aatcagatgc cactggccag acacagcttc cctgccaggg 720
atcctcgagg gacagcacag aacagctggg cccagtatct ggaccctctc caccactcac 780
gggtgctagt agctgccctg aggcctacaa gcggctcttg tcaagctttt actgcaaagg 840
ggcgcatggc atcatgtcac cactggccaa aaagaaactc ctggcccagg tcagcaaggc 900
agaggccttg cagtgccaag aagagggctg tcgccatgga gcaaggagcc ccaacaagga 960
cattcaagac agtccccaga acctaagagg gccggctgag aactctgaac accagctaac 1020
cccccgggaa ggattgcagg cccctggtgg gagcaccagg atggaggccc aagtgggccc 1080
ctgccctaca gcccccatgt tctcaggctg ttttcatgcg taccccaccg aggtgctgaa 1140
acctgtcagc cagcacccta gggacttctt ctccggcctt aaagacaggg tgctgttggg 1200
accacctggt aaagaagaag gtccgacaac caaagagtcc catctggtgt ggggtgggga 1260
tgccaaccac ccctctgcat tccataaagg cagcacaaga aaaagaagtt tctaccccaa 1320
acccaaagcc tgctgggtgt ctcccatggc caaggtccct actgagaggc ctggagcccc 1380
atcccctcat cccagtagcc caggtcttgg cagtaagcgc ggcttggaag aagagggatt 1440
cgctcatggt ggcaagaaac tgagggcagt gtctcccttt ctgaaggagg tggattccaa 1500
ggagactggg ggcaagcctg cagcccctgg cttggctgta tcctgtctac tgggcccaac 1560
cccggggccc actcctccag aggcctacag gggcaccatg ctgcggtgtc ctctaaactt 1620
caccggtagc gcagaccctc tgaagggcca ggcctcactc cccttcagcc ccctggtcat 1680
ccctgctttc ccagcccacc ttctggctac aacaggctcc tcacctatgg ctgccagcct 1740
gatgcatttc cctcccacgc cctatgacgc tgtcctacgc aacagactgg gtccagcttc 1800
gtctgcctgg cacatgccac ccgtcacaac ctatgcggca cctcacttct tccacctcaa 1860
caccaaactg taggccagag cctatcctgc tatgctgtgg aggatttgat gggcagctgc 1920
cgccattatc tcaggcctga gccgactacc cagattccca ggccagtgag gctccccgag 1980
tctgtgtctc tctggtacag acagcaggga ggcagtgggg cttgtctgaa tgaagcagcc 2040
cgggcccaaa gccaggggac caagttgtgg taagatcatg aaagtacctg agctggtatt 2100
ttctctccac tgagaggccg gggagctagt tggcagctca aggcatccag gttggccatg 2160
aaagacccaa taaaaagaca ctggtgtgat tgcactcagc cctggggtgt acagcactgg 2220
atgtttgcaa ggggaggtga ggcaggagca agtgtgtagg tgtggtgacc aatgtgcgag 2280
caaagatgaa aggaggccac tctggcctgg ctgccatcac cccactggaa gggtggcagg 2340
gccagagcca aactcagcct ctggtgcaca gatgaacagc tgtgattcct ttcgctccag 2400
ctccagcctc ggggcacctg actgttgagg ttgccacggt gccaaagccc agagcacact 2460
ggtgacctgt gagacaagat ggaggggctg tgtcactgca accctctgag ctgagccaca 2520
cgcccccatc ccagaaggcc tcgggtcttt cagtgaacgg catcacttgc tctgagaggt 2580
tcttgctgtg ttgctcaggt tagtctcgga ctcccgacct aaagaattcc tgctgcggcc 2640
ttctcagtag ctggaactac tggtgtgaac ctgtgaagag gggatttgtg ggagctcaca 2700
taaaacccaa gtgaatctgt cctggtagtg ggcagacctg tgagcccagc tgcctagtgt 2760
tcccagtgag cgacctgtca cattcacacc tactttcctg ttctacatac tgggtgaagg 2820
gtagagggga cccatctcta cctgtgaatc tgttgccaag tcacagtgat atttacctgt 2880
ggttgctcca ggtgcccaca cagaaatccc atggcttggc acccattcct accttggaca 2940
tggcttgctc tgccagtccc aaggagactg tcagtacagc ttcacactgt tcctggaaag 3000
gcagtgccac tgtggaccag agatgccagg atgccagtga gccaagtcaa cagatggtta 3060
ctgacctaca tcatgggaac tcaccctgtt cctgacctca ggccatgggt aggagggcaa 3120
gtttttatgg cccccttagt tcacaggcgg aatggccaag gccagagaca gcaggtgtca 3180
ttgaggatgt ctggctctgg gaaacgggtg gccagggaaa gcagctgcct gtggaaaaga 3240
gctgggacac aggtgtcctc caagaccagg tagctagagg gtaagggtcc cactgatgca 3300
tcttgcaact ccccaccttc cttctggaga taccaggatg ccagcctgag tattcagatg 3360
acaagccctg agctcctggc taccccactg cacccatgtg ctacctgtct gggagctttt 3420
acagccccgt gaggagggat tctaggctag caaatgccct ggctgttggg ctgtacactg 3480
tggggtcagg tcccaggata gacagagggt accttcgtgc gtgcgtggaa ggatcccctt 3540
catctacaaa gtaacactag tctcaacctg ctcaaaggtg gcgtatgaca gacagcctga 3600
taatggtagc ttgttccaag ctgcaggaac ggagccctct gcaggttcat ctggagaata 3660
cacagctggg agggtagggt gtgtggcttt ctgggttgta ctccactctg cttcagcaaa 3720
aactctagaa atgaatgcac atcaggcttc ctgggaaatc ttgggacttt gcacccatgc 3780
gctagcccca catgattctc cttccttctg tgaatgagag aactcagctc agaggtgact 3840
ccaaacactg tggtacacac accttcctat gttcacttgt gtccctaaca ggttccccca 3900
gaggacccac aggccagcaa agctcttggc gtctgtgtcc agggcataac ttgtggtctg 3960
agcctacttc caaatcattc gtgacatttg agctaataat ggtgggagga ggcagaggcc 4020
actctggtat ttgtgctgac cccacccctg tccgtggtcc tggctcattt ccctggaaac 4080
agcttaagtg tgatgagttg ggcattcagt gggaaatacc tttgtttgcc ttgggtgtca 4140
aagcatgctg cccctgtaac tgtcttaggt ggcattggtt agcattacat gtgcatctcc 4200
cacacgaggc aagtatcacc accgccatag ttgtttggtt ggttggtttt cttggcttct 4260
ttttaagaca ggatttctct gtgtagccct ggctgacctg gaacttactc tgtagaccag 4320
gctggtctct aatagaggtc caccctctgc ctctacttgg attaaagata tgcaccacca 4380
tgcccagcaa ccacctcgcc cagcaaccat cagagtttta aaccgaatgg ctgggaattt 4440
tcctttgaag accttgcgaa tggctacagg aggtgatgga gaaacagcag caagtccccg 4500
agggagtggc gagagagtgg ggccaggagc caggggggct gttgggcagg gacggaggaa 4560
gccagagatg acttaggctg catttagaac cttctagtcc aggaggcagt tgggctttta 4620
tgtgaaataa agaaagatgg aagagagtcc tggctcccag atttggttgt ttgctttatg 4680
gtgctaggga tggaaccctg gacatttttt atgctcagca agctctgatc acttgctgca 4740
tcccagccct ggactctggc aagtggtagg tgtggacact ggagactaga acagagtagg 4800
gaacgtatcc ttggagatgg cagagtcaac atctggacac aggtctggag atgctgcgga 4860
cacatctggc cagcgtgtct gtttatactg tgagcagagt gagtgtgggg gctgggcttg 4920
gagaagggaa gcgagctagg cagtgatcac agtagagcaa agccgtccaa gggcacagcc 4980
agggcacaag agctcgggtt tccacttgac cttagcagcg tgagtatcat tgcacctagg 5040
aggccggctg gacacaatct caaggcaagg gacaactaag caccactcca gtgggagccg 5100
aagtggctgc atgaagggca tcaacagaga accagggaat gaagtgggga tggggggagg 5160
gagttgggaa cagtgggtaa gatctctaga ctgcagatct tggtgtgctg tggggacttg 5220
atggggtggg tgcacatgag aggcttggct gaatcagcag ctattggttg ctggatgagc 5280
tagagcaaga aggggtcaac agagctcagg catgggggac tttgaaacaa gggcagcggg 5340
catgctgggt gggcacagcc gccagggtaa ggtgtgtagg cacaggaaag gaggtgatgg 5400
ggcctcagca aaaaacacag cacaggaggc aagaagcaaa ggttaccttc cacatgaagt 5460
tgctgggctg gccagagcct tagactggca gaatagacat tagagaaggc cagaggcaat 5520
gaaaaacttc atggctttaa aggaatttta aatcaagagc agaggctgcc tggcatgttt 5580
agatgtgttt gttttctagt gtgctggatg gaacccagag ccttgggtat gctgggcaag 5640
tatccaacac tgagctatat catttggtgt tttttaaaaa aaagaattaa caatatttg 5699
<210> 7
<211> 6102
<212> DNA
<213> 智人
<400> 7
gtctctgtcc atccagactc ctgacgttca agttcgcagg gacgtcacgt ccgcacttga 60
acttgcagct caggggggct tttgccattt ttttcatctc tctctctctc tctccctcta 120
tctctcttct ctctctctcc ctcttttttt tttttttttt tttttttttt ttgcttaaaa 180
aaaagccatg acggctctcc cacaattcat cttccctgcg ccatctttgt attatttcta 240
atttattttg gatgtcaaaa ggcactgatg aagatatttt ctctggagtc tccttctttc 300
taacccggct ctcccgatgt gaaccgagcc gtcgtccgcc cgccgccgcc gccgccgccg 360
ccgccgcccg ccccgcagcc caccatgtct cgccgcaagc aaggcaaacc ccagcactta 420
agcaaacggg aattctcgcc cgagcctctt gaagccattc ttacagatga tgaaccagac 480
cacggcccgt tgggagctcc agaaggggat catgacctcc tcacctgtgg gcagtgccag 540
atgaacttcc cattggggga cattcttatt tttatcgagc acaaacggaa acaatgcaat 600
ggcagcctct gcttagaaaa agctgtggat aagccacctt ccccttcacc aatcgagatg 660
aaaaaagcat ccaatcccgt ggaggttggc atccaggtca cgccagagga tgacgattgt 720
ttatcaacgt catctagagg aatttgcccc aaacaggaac acatagcaga taaacttctg 780
cactggaggg gcctctcctc ccctcgttct gcacatggag ctctaatccc cacgcctggg 840
atgagtgcag aatatgcccc gcagggtatt tgtaaagatg agcccagcag ctacacatgt 900
acaacttgca aacagccatt caccagtgca tggtttctct tgcaacacgc acagaacact 960
catggattaa gaatctactt agaaagcgaa cacggaagtc ccctgacccc gcgggttggt 1020
atcccttcag gactaggtgc agaatgtcct tcccagccac ctctccatgg gattcatatt 1080
gcagacaata acccctttaa cctgctaaga ataccaggat cagtatcgag agaggcttcc 1140
ggcctggcag aagggcgctt tccacccact ccccccctgt ttagtccacc accgagacat 1200
cacttggacc cccaccgcat agagcgcctg ggggcggaag agatggccct ggccacccat 1260
cacccgagtg cctttgacag ggtgctgcgg ttgaatccaa tggctatgga gcctcccgcc 1320
atggatttct ctaggagact tagagagctg gcagggaaca cgtctagccc accgctgtcc 1380
ccaggccggc ccagccctat gcaaaggtta ctgcaaccat tccagccagg tagcaagccg 1440
cccttcctgg cgacgccccc cctccctcct ctgcaatccg cccctcctcc ctcccagccc 1500
ccggtcaagt ccaagtcatg cgagttctgc ggcaagacgt tcaaatttca gagcaacctg 1560
gtggtgcacc ggcgcagcca cacgggcgag aagccctaca agtgcaacct gtgcgaccac 1620
gcgtgcaccc aggccagcaa gctgaagcgc cacatgaaga cgcacatgca caaatcgtcc 1680
cccatgacgg tcaagtccga cgacggtctc tccaccgcca gctccccgga acccggcacc 1740
agcgacttgg tgggcagcgc cagcagcgcg ctcaagtccg tggtggccaa gttcaagagc 1800
gagaacgacc ccaacctgat cccggagaac ggggacgagg aggaagagga ggacgacgag 1860
gaagaggaag aagaggagga agaggaggag gaggagctga cggagagcga gagggtggac 1920
tacggcttcg ggctgagcct ggaggcggcg cgccaccacg agaacagctc gcggggcgcg 1980
gtcgtgggcg tgggcgacga gagccgcgcc ctgcccgacg tcatgcaggg catggtgctc 2040
agctccatgc agcacttcag cgaggccttc caccaggtcc tgggcgagaa gcataagcgc 2100
ggccacctgg ccgaggccga gggccacagg gacacttgcg acgaagactc ggtggccggc 2160
gagtcggacc gcatagacga tggcactgtt aatggccgcg gctgctcccc gggcgagtcg 2220
gcctcggggg gcctgtccaa aaagctgctg ctgggcagcc ccagctcgct gagccccttc 2280
tctaagcgca tcaagctcga gaaggagttc gacctgcccc cggccgcgat gcccaacacg 2340
gagaacgtgt actcgcagtg gctcgccggc tacgcggcct ccaggcagct caaagatccc 2400
ttccttagct tcggagactc cagacaatcg ccttttgcct cctcgtcgga gcactcctcg 2460
gagaacggga gtttgcgctt ctccacaccg cccggggagc tggacggagg gatctcgggg 2520
cgcagcggca cgggaagtgg agggagcacg ccccatatta gtggtccggg cccgggcagg 2580
cccagctcaa aagagggcag acgcagcgac acttgtgagt actgtgggaa agtcttcaag 2640
aactgtagca atctcactgt ccacaggaga agccacacgg gcgaaaggcc ttataaatgc 2700
gagctgtgca actatgcctg tgcccagagt agcaagctca ccaggcacat gaaaacgcat 2760
ggccaggtgg ggaaggacgt ttacaaatgt gaaatttgta agatgccttt tagcgtgtac 2820
agtaccctgg agaaacacat gaaaaaatgg cacagtgatc gagtgttgaa taatgatata 2880
aaaactgaat agaggtatat taatacccct ccctcactcc cacctgacac cccctttttc 2940
accactcccc ttccccatcg ccctccagcc ccactccctg taggattttt ttctagtccc 3000
atgtgattta aacaaacaaa caaacaaaca gaagtaacga agctaagaat atgagagtgc 3060
ttgtcaccag cacacctgtt ttttttcttt ttctttttct tttttctttt tccttttttt 3120
tttttttcct ttatgttctc accgtttgaa tgcatgatct gtatggggca atactattgc 3180
attttacgca aactttgagc ctttctcttg tgcaataatt tacatgttgt gtatgttttt 3240
ttttaaactt agacagcatg tatggtatgt tatggctatt ttaaattgtc cctaattcgt 3300
tgctgagcaa acatgttgct gtttccagtt ccgttctgag agaaaaagag agagagagag 3360
aaaaagacca tgctgcatac attctgtaat acatatcatg tacagtttta ttttataacg 3420
tgaggaggaa aaacagtctt tggattaacc ctctatagac agaatagata gcactgaaaa 3480
aaaatctcta tgagctaaat gtctgtctct aaagggttaa atgtatcaat tggaaaggaa 3540
gaaaaaaggc cttgaattga caaattaaca gaaaaacaga acaagtttat tctatcattt 3600
ggttttaaaa tatgagtgcc ttggatctat taaaaccaca tcgatggttc tttctacttg 3660
ttataaactt gtagcttaat tcagcattgg gtgaggtaat aaaccttagg aactagcata 3720
taattctata ttgtatttct cacaacaatg gctacctaaa aagatgaccc attatgtcct 3780
agttaatcat catttttcct ttagtttaat tttataaaca aaactgatta taccagtata 3840
aaagctactt tgctcctggt gagagcttaa aagaaatggg ctgttttgcc caaagtttta 3900
ttttttttaa acaatgatta aattgaatgt gtaatgtgca aaagccctgg aacgcaatta 3960
aatacactag taaggagttc attttatgaa gatatttgct ttaataatgt ctttttaaaa 4020
atactggcac caaaagaaat agatccagat ctacttggtt gtcaagtgga caatcaaatg 4080
ataaacttta agaccttgta taccatattg aaaggaagag gctgacaata aggtttgaca 4140
gaggggaaca gaagaaaata atatgattta ttagcacaac gtggtactat ttgccattta 4200
aaactagaac aggtatataa gctaatattg atacaatgat gattaactat gaattcttaa 4260
gacttgcatt taaatgtgac attcttaaaa aaagaagaga aagaatttta agagtagcag 4320
tatatatgtc tgtgctccct aaaagttgta cttcatttct tttccataca ctgtgtgcta 4380
tttgtgttaa catggaagag gattcattgt ttttattttt atttttttaa ttttttcttt 4440
tttattaagc tagcatctgc cccagttggt gttcaaatag cacttgactc tgcctgtgat 4500
atctgtatct tttctctaat cagagataca gaggttgagt ataaaataaa cctgctcaga 4560
taggacaatt aagtgcactg tacaattttc ccagtttaca ggtctatact taagggaaaa 4620
gttgcaagaa tgctgaaaaa aaattgaaca caatctcatt gaggagcatt ttttaaaaac 4680
taaaaaaaaa aaaactttgc cagccattta cttgactatt gagcttactt acttggacgc 4740
aacattgcaa gcgctgtgaa tggaaacaga atacacttaa catagaaatg aatgattgct 4800
ttcgcttcta cagtgcaagg atttttttgt acaaaacttt tttaaatata aatgttaaga 4860
aaaatttttt ttaaaaaaca cttcattatg tttagggggg aactgcattt tagggttcca 4920
ttgtcttggt ggtgttacaa gacttgttat ccatttaaaa atggtagtgg aaattctatg 4980
ccttggatac acaccgctct tcaggttgta aaaaaaaaaa acatacattg gggaaaggtt 5040
taagattata tagtacttaa atataggaaa atgcacactc atgttgattc ctatgctaaa 5100
atacatttat ggtctttttt ctgtatttct agaatggtat ttgaattaaa tgttcatcta 5160
gtgttaggca ctatagtatt tatattgaag cttgtatttt taactgttgc ttgttctctt 5220
aaaaggtatc aatgtacctt ttttggtagt ggaaaaaaaa aagacaggct gccacagtat 5280
atttttttaa tttggcagga taatatagtg caaattattt gtatgcttca aaaaaaaaaa 5340
aaagagagaa acaaaaaagt gtgacattac agatgagaag ccatataatg gcggtttggg 5400
ggagcctgct agaatgtcac atggatggct gtcatagggg ttgtacatat ccttttttgt 5460
tcctttttcc tgctgccata ctgtatgcag tactgcaagc taataacgtt ggtttgttat 5520
gtagtgtgct ttttgtccct ttccttctat caccctacat tccagcatct taccttcata 5580
tgcagtaaaa gaaagaaaga aaaaaaaagg aaaaaaaaaa aaaaaccaat gttttgcagt 5640
ttttttcatt gccaaaaact aaatggtgct ttatatttag attggaaaga atttcatatg 5700
caaagcatat taaagagaaa gcccgcttta gtcaatactt ttttgtaaat ggcaatgcag 5760
aatattttgt tattggcctt ttctattcct gtaatgaaag ctgtttgtcg taacttgaaa 5820
ttttatcttt tactatggga gtcactattt attattgctt atgtgccctg ttcaaaacag 5880
aggcacttaa tttgatcttt tatttttctt tgtttttatt ttttttttta tttagatgac 5940
caaaggtcat tacaacctgg ctttttattg tatttgtttc tggtctttgt taagttctat 6000
tggaaaaacc actgtctgtg tttttttggc agttgtctgc attaacctgt tcatacaccc 6060
attttgtccc tttattgaaa aaataaaaaa aattaaagta ca 6102
<210> 8
<211> 6122
<212> DNA
<213> 小家鼠
<400> 8
gacgttcaag ttcgcaggga cgtcacgtcc gcacttgaac ttgcagctca ggggggcttt 60
tgccattttt ttcatctctc tctctccctc tatccctctt ctctcttcct ctctctcttt 120
tttttcctta aaaaaaaaaa agccatgacg gctctcccac aattcatctt ccctgcgcca 180
tctttgtatt atttctaatt tattttggat gtcaaaaggc actgatgaag atattttctc 240
tggagtctcc ttctttctaa cccggctctc ccgatgtgaa ccgagccgtc gtccgcacgc 300
cgccgccgcc gccgccgccc gccccgcagc ccaccatgtc tcgccgcaag caaggcaaac 360
cccagcactt aagcaaacgg gaattctcgc ccgaacctct tgaagccatt cttacagatg 420
atgaaccaga ccatggcccg ttgggagctc cagaagggga ccacgacctt ctcacctgtg 480
ggcagtgcca gatgaatttc ccactggggg acattcttat ttttatcgag cacaaacgga 540
aacaatgcaa tggcagcctc tgcttagaaa aaggtgtgga taagccgcct tccccttctc 600
ccatcgagat gaaaaaggca tccaatcctg tggaggttgg catccaggtc acgccagagg 660
atgacgattg tttatcaacg tcatctagag gaatttgccc caaacaggaa cacatagcag 720
ataaacttct gcactggagg ggcctgtcct ctcctcggtc tgcacacgga gctctaatcc 780
ccacgcccgg gatgagtgca gaatatgccc cgcagggtat ttgtaaagat gagcccagca 840
gctacacatg tacaacttgc aaacagccat tcaccagtgc atggtttctc ttgcaacacg 900
cacagaacac tcatggatta agaatctact tagaaagtga acacggaagt cccctgaccc 960
cgcgggttgg tatcccttca ggactaggtg cagaatgtcc ttcccagcca cctctccatg 1020
ggattcatat tgcagacaat aaccccttta acctgctaag aataccagga tcagtatcga 1080
gagaggcttc cggcctggca gaagggcgct ttccacccac tccccccctg tttagtccac 1140
caccgagaca tcacttggac ccccaccgca tagagcgcct gggggcggaa gagatggccc 1200
tggccaccca tcacccgagt gcctttgaca gggtgctgcg gttgaatcca atggctatgg 1260
agcctcccgc catggatttc tctaggagac ttagagagct ggcagggaac acgtctagtc 1320
caccgctgtc cccaggccgg cccagtccta tgcaaaggtt actgcaacca ttccagccag 1380
gtagcaagcc acccttcctg gcgacgcccc ccctccctcc tctgcaatcc gcccctcctc 1440
cctcccaacc cccggtcaag tccaagtcat gcgagttctg cggcaagacg ttcaaatttc 1500
agagcaactt ggtggttcac cgacgcagcc atactggtga gaagccctat aagtgcaacc 1560
tgtgcgacca cgcgtgcaca caggccagca agctgaagcg tcacatgaag acacacatgc 1620
acaaatcgtc ccccatgaca gtcaagtccg acgatggcct ctccacagcc agctccccgg 1680
aacctggtac cagcgacctg gtgggcagcg ccagcagtgc gctcaagtca gtggtggcca 1740
agttcaagag tgagaacgac cccaacttga tcccagagaa cggggatgag gaggaagagg 1800
aggacgacga ggaagaagaa gaagaggagg aagaggagga ggaggagctg acggagagcg 1860
agagggtgga ctacggcttc gggctgagcc tggaggctgc acgccaccat gagaacagct 1920
ctcggggcgc agtggtgggc gtgggcgacg agggccgcgc cctgcccgat gtcatgcagg 1980
gcatggtgct cagctccatg cagcacttca gcgaggcctt ccaccaggtc ctgggcgaaa 2040
agcataagcg tagccacctg gccgaggccg agggccatag ggacacttgt gatgaagact 2100
cggtggccgg tgagtcagac cgcatagacg atggcactgt taatggtcgt ggctgctccc 2160
ccggcgaatc ggcttcgggg ggtctgtcca aaaagctgct gctgggtagc cccagctcgc 2220
tgagcccctt ctccaagcgc atcaagctgg agaaggagtt tgacctgccc ccggccgcga 2280
tgcctaacac ggagaacgtg tattcgcagt ggctcgctgg ctatgcggcc tccaggcagc 2340
tcaaagatcc cttccttact ttcggagact ccagacaatc gccttttgcc tcctcatcag 2400
agcactcctc ggagaacggg agcttgcgct tctccacacc gcccggggag ctggacggag 2460
ggatctcagg gcgcagcggc acaggaagtg gagggagcac gccccatatt agtggtccgg 2520
gcccgggcag gcccagctca aaagagggca gacgcagcga cacttgtgag tactgtggga 2580
aagtcttcaa gaactgtagc aatctcactg tccacaggag aagccacacg ggcgaaaggc 2640
cttataaatg cgagctgtgc aactatgcct gtgcccagag tagcaagctc accaggcaca 2700
tgaaaacgca tggccaggtg gggaaggacg tttacaaatg tgaaatttgt aagatgcctt 2760
ttagcgtgta cagtaccctg gagaaacaca tgaaaaaatg gcacagtgat cgagtgttga 2820
ataatgatat aaaaactgaa tagaggtata ttaataccct ccctcactcc cacttgatgc 2880
cccccttcca ccccttcccc attgtccttc cagccctact ccctgtagga tttttctagt 2940
cccatgtgat caaacaaaca aacaaacaaa caacagaggt aatggaagct aagaatatga 3000
atgagtgctt gtcaccagca cacctggttt tttgttttgt ttttcctttt ttttttcttt 3060
ttcttcttct tttttttaaa ttttaaattc tttatgttct caccgtttga atgcatgttt 3120
ggggcaatac tattgcattt tacgcaaact ttgagccttt ctcttgtgca ataatttaca 3180
tgttgtgtat gtttttcccc ccttaactta gacagcatgt atggtatgtt acggctattt 3240
taaattgtcc ctaattcatt atgagcaaac atgttgttgc tgtttccagt tccattctga 3300
gagtgtgagg gagggagggt agaaaacaac gcatgctgca tacataattc tgtaatacag 3360
atcatgtgca gctttatttt ataacacgag gagggaaacg gtgtctgggt tgactaaccc 3420
tctgcagaca gagcagatag cagtgaaaaa aaggtgctaa atgtctgtct ctaaagggtt 3480
acatgtatta attggagagg gaaaaaaggc cttgaattga caaattaaca gaagaacaag 3540
tttattctat catttggctt ttaaaatgag tgccttggat ctattcaaac catgttgatg 3600
gttttttttc tgcttgttat aaacttgtag tttaatctag cattgggtga ggtaataaac 3660
tttaggacct agcatgtaat tctgtgttgt atttctcaca acaatggcta cctaaaaata 3720
tgacccatta tgtcctagtt aatcattgat ttttgccttt aactttgtga acaaaactga 3780
ttataccagt ataaaagcta ctttgctcct tgtgagagca taaaagaaat gggctgtttc 3840
gcctaaagtt ttattttatt ttatttttaa atggttatca aattgaatgt gaaatgtgca 3900
aaggccctgg aatgtgatga aatacattag caagaagttc atcttgtgac aatacttgtt 3960
taaaatgatg catttaatga aattctggcg ccaaaagaag tagatccggc tctagttggt 4020
tgttgagtgg acaataaaat gataaagccc tttagaggac atttgaaaga acaggctgat 4080
atgatgagag agagagagag agacagaaaa cggtagtgat tggttagcac gatgtagtac 4140
tgtttgccat ttgaaactag aacaggtgta taaggggcca gcgatacaat gatgattaac 4200
tctgaagctc taagacttgc atttaatgtg acagtcttca aaaagaagag gaagaccttt 4260
aagagcagca gtatctatgt ctgtgctccc tggaagttgt acttcatttc ttttccatac 4320
actgtgtgct atttgtgtta acattgaaga ggatttgttt ttattttgtt ttattctttc 4380
tttctttctt ttttcttcct tctttgtttt aagctagcat ctgccccagt tggtgttcaa 4440
atagcacttg actctgccta tgatacctgt atcttttctc taatcagaga tacagaggtt 4500
gagtataaaa taaacctgct cagataggac aattaagtgc actgtacagt tttcccagtt 4560
tacaggtctt tattaaggga aacgttgcaa gaatgctgaa aacaattgaa cacaatctca 4620
atgatgagca ttaaaaaata ataaaaaaaa acaagcaaac ctaaaaaaaa ctaagacaga 4680
cgttgccagc cattgacttg actattgagc ttcctcactt ggatgcaaca ttgcaagcgc 4740
tgtggatgga aacaacacac ttaacataga aacgaatgac tcctttgctt ctacagtgca 4800
aggatttttg tacaaaactt ttttaagtat aaatgttaag aaaagaattt ttaaaaagac 4860
acttcattat gtttaggggg gaacagcatt ttagggttcc attgtcttgg tggtgttaca 4920
agacctgtta tccatttaaa aatggtagtg gaaattctat gccttggatc acacaccgct 4980
cttcaggttg taaaaaaaaa tgaaaacaaa acaaaacaaa aaaaaaacat acatggggaa 5040
aggtttaaga ttatatagta cttaaaaata ggaaaacgca cactcatgtt gattcctatg 5100
ctaaaacaca gttatggtct tctttctgta tttctagaat ggtatttgaa ttaaatgttc 5160
atctagtgtt aggcactata gtatttatat tgaagcttgt atttttaact gttgcttgtt 5220
cactcaaaag gtatcaatgt acctttttgt tagtagaaaa aaaaagacag gctgccacag 5280
tatatttttt taatttggca ggataatata gtgcaaatta tttgtatgct gagagagaga 5340
gagagagaga gagagagaga gagagaggtg tgacattgta cagagaagcc atataatggc 5400
ggtttgggga gcctgctaga atgtcacatg gatggctgtc ataggggttg tacatatcct 5460
tttccccctt tcctgctgcc atgctgtacg cagcactgca agctaatagc gttggtttgt 5520
tatgtagtgt gctttggccc ctcctccccg ctcacccgac attccagcat cttaccttca 5580
tatgcagtaa aagaaagaaa gaaaaaaaaa aaggaaaaaa aaaacaacaa caatgttttg 5640
cagttttttt cattgccaaa aactaaatgg tgctttatat ttagattgga gagaatttct 5700
tatgcaaagc atattaaaga gaaagcccgc tttagtcaat acttttttgt aaatggcaat 5760
gcagaatatt ttgttattgg ccttttctat tcctgtaatg aaagctgttt gtcgtaactt 5820
gaaattttat cttttactat gggagtcact atttattatt gcttatatgc cctgttcaaa 5880
acagaggcac ttaatttgat cttttatttt tctctgtttt tattattatt ttttttaatt 5940
tggatgacca aaggtcattg caacctggct ttttactgta tttgtttctg gtctttgtta 6000
agttctattg gaaaaaccac tgtctgtgtt tttttggcag ttgtctgcat taacctgttc 6060
atacacccat tttgtccctt tattgaaaaa aaataaaaaa attaaagtac taaaaaaaaa 6120
aa 6122
<210> 9
<211> 4480
<212> DNA
<213> 智人
<400> 9
aaaccggaat ggcccgaggg aaggccgcgc agggcagggc cccagatggt tcctgtcagg 60
gaagtggcgg gcgcagctgc aggcctccgg ccccggcatt atcacgggga cacagctggc 120
tgcctcaccc gcaggctgca gggagacctt ccccagcctg cagccccagg cccgccccgc 180
gtcacatgag ccccagggct cccaccccct ccccagggca gaggacaccc agttggtggc 240
cgggagggcc tcggctttcc agggacagag gcccaactcc aggacgcccc agctggccca 300
gcccctcctc tttccctcaa ggctgcagga ggtcgggaaa ggcagtcctg gtagaggcct 360
gtcctgggct ccaggttggc ccctgagggt ggccctcctc atgccggctt caagactgag 420
ggacagggca gccagttcag cctcgggatc cacctgtggc tccatgtccc agacgcaccc 480
tgtgctggag agcggcctcc tggcatctgc cggctgctcc gcaccccggg gtcccaggaa 540
gggcggccca gccccagtgg acaggaaagc taaggcctca gcgatgccgg actccccagc 600
ggaggtgaag acgcagcccc ggtccacacc ccccagcatg ccgcccccac cgcctgccgc 660
atcccagggg gccacacgcc ccccctcctt cacgccacac acacatcgag aggacgggcc 720
tgcgacgctg ccccacggcc gttttcatgg ctgcttaaaa tggtctatgg tctgtctctt 780
gatgaacggc agcagccact caccaacagc catcaatggt gcaccgtgca cacccaacgg 840
cttcagcaat ggcccggcca cctcgtccac agcctccttg tccacacagc acctgccccc 900
agcctgcggg gcccggcagc tcagcaagct caagcgcttc ctcaccacac tgcagcagtt 960
tggcagcgac atctccccag agattgggga gcgcgtgcgc acactggtgc tgggcctggt 1020
gaactcgaca ttgacgatcg aggagtttca ttccaagctt caggaggcca ccaacttccc 1080
tctgcggccg tttgtcattc ccttcctgaa ggcaaacctg cccttgctgc agcgggagct 1140
cctgcactgt gcacgcctgg ccaagcagac gcccgcccag tacttggccc agcatgagca 1200
gctcctgctg gacgccagcg cctcctcccc catcgactcc tcagagctgc tactggaagt 1260
caacgagaac ggcaagagga ggacgcccga caggaccaaa gagaacgggt cagaccgcga 1320
cccgctgcac cccgagcacc tcagcaaacg gccatgcacc ctgaaccctg cccagcgcta 1380
cagccccagc aacgggccac cgcagcccac accgccgccg cactaccgcc tggaggacat 1440
agccatggcc caccacttcc gagatgccta ccgccaccca gacccccggg agctacgaga 1500
gcgccatcgg ccgcttgtgg tgcctgggtc ccggcaggaa gaagtgatcg accacaagct 1560
cacagagcgt gagtgggcag aagagtggaa gcacctcaac aacctcctga actgcatcat 1620
ggacatggtg gagaagacgc ggcgctcgct cacggtgctg cgcaggtgcc aggaggccga 1680
ccgcgaggag ctcaaccact gggcgcggcg ctacagcgac gccgaggaca caaagaaggg 1740
ccccgctccc gccgcggccc ggccccgcag cagctccgcc ggtcccgaag ggcctcagct 1800
agacgtgcct cgcgagttcc tgccgaggac cctcaccggc tacgtgcctg aggacatctg 1860
gaggaaggct gaagaggccg tgaatgaggt gaagcggcag gccatgtcgg agctgcagaa 1920
agccgtgtcg gacgcggagc gcaaagcgca cgagctcatc accacggagc gtgccaagat 1980
ggagcgggcc ctggccgagg cgaagcggca ggcctccgag gacgccctga cggtcatcaa 2040
ccagcaggag gactccagcg agagctgctg gaactgcggg cggaaagcca gtgagacgtg 2100
cagcggctgc aacgcggcac gctactgcgg gtccttctgc cagcatcggg actgggagaa 2160
gcatcaccac gtgtgtggcc agagcctgca gggccccaca gccgtggtgg ccgacccggt 2220
gcctggaccg cccgaagccg cccacagcct gggcccctcc ctgcctgtgg gtgctgccag 2280
ccccagcgaa gccggctctg cggggccttc tcgccccggc tcccccagcc cacctggccc 2340
actggacacc gtgccccgct gaccccactg gcccctggcc tgccggacac agcaccgtgc 2400
caaccccacc cagctccagg cccaccggat gctgtgcctg gcctccgatg cctggcctgc 2460
cagacactgc gccccgcctg acctggggga gccgaccaat tagtcactgc tgctactgcc 2520
cctctccgaa agaagacaca gaaccaacaa aaccgcattc agtgcacctg cctcagctac 2580
ctaatgattc cgcgcggaga cctcctgaca acgtctcttc aagcatcctc agaagcctcg 2640
actgagcttt agacagcaga gcagatgccg caggcgcggc ggctctgccc acctctcttt 2700
tcctctctgt ctgtctctcc ccctctgtct tctctatcct ctctctctct atgactatca 2760
cacactttct cttcaatgaa aaaatcgaat tggtggctta tattttcagc aaagaatttt 2820
ggggggtttt gtgtgttggc aaaagagcta ctcagaaatg gacaaagaaa acgggggggt 2880
tctccccctc ctgattaaaa agggagaaag aaaactgcga ttttatagct ggagatctga 2940
acccagctgt gcccctcccc caggggcgtg aggctgatca gcgaagacgg gaggaaagat 3000
ttcgatttct gactcaagat gcatttttgg tttcagattt ttttttcctg taatgttaaa 3060
ctctttggct ttaagtaaaa atccaaaaag tttttttaaa aaagcaaagg aagcatactt 3120
gtgaactacc ttgctagcta gccagccaag gataccggac acacctctgc tccaaaggaa 3180
atccaaaaaa gcaaacacaa gaaatcaaaa tccaaaattt gtttgtcact gccaaagtat 3240
ttttttcact gtttcacttg ctcttgggtt tgtttggatg tgggtctttt tctcttctgt 3300
tctgattttg tttgtgggtg tcgggatatt tgggtgcaga gggtttgtgc ccagttagaa 3360
gcgacttttg ttctcttctg cgtaggcgtt ggtgcgtccg ccgcgtgtgc gtggtccgtg 3420
tgccgttgct ccggcctgcg tctccatatg tgtaggaaag gacacgccgt ctgtcctcac 3480
gccccctgtg acttttcata tttccgtttt ccacttgtgg aaaaaaagtg ctaaagtttt 3540
cttcccagag agagcataat tccgaaacaa aactgtgaca atcttttggg ttgattctcg 3600
actgcttttc gagcatgcgg agccagcagg cctccctgaa acactgcttc tcggccagcc 3660
cgtcctcctc tacctctctc ctctccgcgc cctccgacct ctctcggccc cctcacccca 3720
gctccgacct ctctcagccc catcgcccca actccaacct ctcggcccca tcgccccacc 3780
gcagctactc ccctttcttc caaacttttg cagaaaaaac aaaaaaacta caaacaaaag 3840
cagccctctg cctcctcccc agggaagacc ctgaccgtgt acatagccct ggtgctcctg 3900
cccagccacc cctcagatgc gttcgcctct ggccctgggg tgtgtctcgg tgacgttttc 3960
tatcagacgt gctccctccc atcctccagc cctgcccacc ctccctccac tcctctcaac 4020
tgcctcagcg atttcaagaa ggaaataaag ggataaagaa attcatgctt gcaccgagta 4080
caaggacaga cagcaggcac ggcccgcagc ctggcatctg tgcgtgtggc gtggcccgtg 4140
gcttggcatc tgtgtgcgtg gtgtggcccg tggcctggca tctgtgtgcg tggcgtggcc 4200
cgtggcctgg catctgtgtg tgtggcgtgg cccgtggcct ggcatctgtg cgcgtggcgt 4260
ggcccgtggc ctggcatctg tgtgcgtggc tatcaggagt tctaggaact cagtgcaata 4320
cgggagtgac ccagctactg aaccagccac gaacagcccg ccagaggcct gaagctgagc 4380
gtgtacgtta atgtgaatgt atatagtctt tgcagaggtc caaatgatat tcatgatggt 4440
aataaacgag atgtttgcca aataaaaaac agaaaccgca 4480
<210> 10
<211> 7659
<212> DNA
<213> 小家鼠
<400> 10
agggccacaa cccagctctg ccggctgtag tgactagaaa ggcctggagc ctccaaggaa 60
cagaggcacg ggctccgaga cgccaaagct cctccagccc tcctgttctc tccagacccc 120
acgaaatcag aaaaggtgct tcagggtggg ctctggaggc cggccagctc cctccagccc 180
caggtaccat caatctccgg ctccatctgc agctccatgt cccaggcatc caccaccact 240
ctggagagtg gggcactcct ctcgggaccc cggggtcttc agaatggaag cccagctcac 300
aggaaggaga aggctgcagc aatgccagac tccccggctg aagtgaagac gcagccccgg 360
tccacacccc ccagcatgcc gcccccacct cccacctcat cccagggagc cacacgacca 420
ccctccttca cacctcacac acatggcgag gatggacctg cgacgtctct tccccatggc 480
cgtttccacg gctgcttaaa gtggtccatg gtctgtctct tgatgaacgg cagcagccac 540
tcacccacgg ccatccacgg tgccccatct acacccaatg gcttcagcaa cggcccagcc 600
acctcatcca cggcctcgct ctccacacag cacctgcccc cggcgtgcgg ggcacggcag 660
ctcagcaagc ttaagcgttt cctcaccacc ctacagcagt ttggcagtga catctcacct 720
gagatcgggg agcgcgtgcg cacactggtg ctgggcctgg tgaactcaac tctgacgatc 780
gaagagtttc atgccaagct ccaggaagcc accaactttc cactgaggcc gtttgttatc 840
ccttttctga aggctaatct tccactgctg cagcgtgagc tcctgcactg tgcccgcctg 900
gccaaacaga cacctgccca gtacctggcc cagcacgaac agctgctgct ggacgccagc 960
gccacctccc ctgtcgactc gtctgagctc ctgctggaag tcaacgagaa cggcaaaagg 1020
agaacacctg acaggaccaa agagaatgga tcagaccggg accctctgca ccccgaccac 1080
ctcagtaagc ggtcctgcac cctgagcccc gcccagcgct gcagccccag caatgggctg 1140
ccccacccga cgccaccccc acccccgcac tatcgcctgg aggacatggc catggcccac 1200
catttccggg actcctaccg ccatcctgat ccccgagagc tacgggaacg ccaccggccc 1260
ctggccatac ctgggtctcg acaagaagaa gtgattgatc acaggctcac agaacgcgag 1320
tgggcagaag aatggaagca cctcaacagt cttctgaact gcatcatgga catggtggag 1380
aagacccggc gatccctcac cgtcctgcgc cggtgtcagg aggccgaccg tgaggaactc 1440
aaccactgga tccggtgcta cagtgactct gaggagggga agaagggccc tacccccatc 1500
tctgcccggt ccctcaacag ctgcagtggc cctgaggggt ctcagctaga tgttcaccgg 1560
gacttcacgc ccaggaccct gtctggctac atgcctgaag agatctggag gaaggctgaa 1620
gaagctgtga atgaggtgaa gcgccaggcc atgtcagaac tacagaaagc tgtgtctgat 1680
gcggagcgca aagcccatga actcatcacc acagagcgtg ccaagatgga acgagccctg 1740
gcggaggcca agcgacaggc ctcggaggat gccctgactg tcatcaacca gcaagaggac 1800
tccagcgaga gctgctggaa ctgcgggcgc aaggccagcg agacgtgcag tggctgtaac 1860
gccgcccgct actgcgggtc cttctgtcag cacaaagact gggagaaaca ccatcacgtg 1920
tgcggccaga gtctgcaggg ccccgcggct gcagtggctg acccactacc tggacagcct 1980
gacgccactg ccagccccag cgaagccggc tcggcagggc cctctcgtcc ctgctctccg 2040
gggccgccag gcccgctgga cgctgctgtg ccccgctgac ctccagatct gacacccagc 2100
ccatggacgc catgccctgc caacctcctg gccccaccgt ggcccaccag ttgcctggag 2160
ccattgctgc tactgcttct ctccaaaaga aaacacagat ccaacagaac tgcatccgtg 2220
cagccccagc tacctgacaa ggtctgccgg gacctctaca gcctctcgtc catcgcaagc 2280
accctcagaa agcatcgcag agcgtcagac agtggcacca gcaggagtgt ggccagctcc 2340
gccgctgtct gtcccctctg tgtccgtctc tctgtgtccg tctgtctttc tgcgtctgcc 2400
tctctctgtg tgtctctccg tgtctttgtc tcctgccgtt tccctgactc tccggcgtct 2460
ctgtctttgt aaagtccaca tgatctctct gtcatcagag aaacctagtt ggtagctttt 2520
cttttccatg aagaactttt ggagattttg ttttgttttg ttggcaaaca agctacttag 2580
aaatggacaa agaagactgt ggggttctcc ccattcctca tgagtaaggg aagaaactgt 2640
gatttttcta tccagagttg ctgtatcgcc cagccagccc caggggcatc agcgagcaca 2700
cagcagagat aatgagagca actgcaattt ccaacttaag aagcagcttt tgtttcaggt 2760
tttactcctt taatgtcaaa ctctttggct ttaagtgaaa aaaaaaaaaa ggaaaaaaaa 2820
atccaaaaag tttttttttt ttttaagcaa aagaaacaca cctgtaaact accttgccag 2880
ctagccagcc aaggatgcca gacacacctc gctccaaagg aagcccaaaa aagcaaactc 2940
aagaaattga aatccaaaat ttatttttat cactgccaaa gtattttctt catggtctct 3000
ccgccctggg ttggtttgca tgtcagtctt tgatttgggt tttgattttg ttcagggggt 3060
gttgggatgc tgggatttgg tgggtggggc caagaagaaa ccttttgttc ctttttgact 3120
agtaggcagc atccttgctg ggcagagcca tcggcagcaa ggccacgtga ccctcagcac 3180
cgcatccaga agccccagtc agcgtgagcc tgagcgttgt gtgccctagg gctccgtcca 3240
tgcgttccct acatgcaagg gaggcacctc cttccatcgg tccccacacc ttcctgggac 3300
ttctcataag tcatttccac ttgtgaaaaa aaaaaaagtg ctaaagtgct cttcccagag 3360
agagcacact tcctaaacga aactgtgaca atctttttgg ttgattcttg actgcttttg 3420
agagcataag gagacagcaa atcacgcttt ctcagttttc cctcctctac ctctctgctc 3480
ttccatccca ccctacctcc atctcggccc catcaccctg cccccagtgt cttgctgtgg 3540
ctaccctcat ttctttcaaa cttttacaga aaaaaaggaa aaagaaaaaa aaaaaacacg 3600
aaagccagca gccacccgca cctcacccgg aagactccag cccggctgta catatccctg 3660
tgttgtatcc ccaatgttgg tctccagtcc tgggggtgac ggtgatgctt gcccatctac 3720
actctagccc ctgcccaccc tgcccttcgc ccgctcgact ccctcaagga ttcaaggagg 3780
aaatgaagga agaaggctca tgcctgtacc aaacaaaaag agacagcaga ctcagtccag 3840
gtctgcacct ctgttgtggc tgcagcaagc cgcaggccta gcgtgcaata tgggggattg 3900
ctcctgaacc ctgggcccgg gggggccctg cccagagcaa ggtgtgcagc gtgtgttaat 3960
gtgaatgtac atagtctcca cagaggtccc aaaccgtggc atcagtaccg aggagatgtt 4020
tgccaaataa aaagaaatta agacaaacca cggaagtctg tgaggtttag gaaacgcttt 4080
ggaaggagtc tgagtcctat aggcttcttt ggtggctggt gtttcttcac agctgtatga 4140
ccattgttta acagaacgtt ctatggattc tgttgggtag cccggaatgg agcctgacag 4200
caacccttgc tcggaaggct ggggtagatc tcattccctg gaaggttccc gcggccgcag 4260
ccctccaagg ccgcagagat gtattcttgt gggtttcaga gaagccagga cacaaggcgg 4320
cctcctgcct gcccgccctt ctctagtgga ccagtcctcc tgagcgtctg cctgcaaaca 4380
ctgagtctgt gtgctggtag agcgagacct gcctcccgtc gcaaggagca tcactggatt 4440
ccattcccaa ctgtacccca tgcggtactt cttgtctctg ctactccact gcatgcagca 4500
accttggccc ttccagaagg gcaggccagt gaccactggt aggaaagagc tctgggtgat 4560
ggggtggtga gcaccatgtt gggggggggg gggaacaaag ctaagcccct caggttgtgc 4620
ttaagagctg tagtctctag aagtccgggc caggagtcct gaggtggcat tcctgatgac 4680
ctacgtccct ggtgtcagga cttcggagca cctgctccta tgtggtccag atattctgag 4740
gtaggtccca aagggtcacc agtttgcttt agttcaaata cctcctttct tacccttacc 4800
agccttaccc accttttagg aacagagggc ccaccacaga caacaaaatg ctgcccagcc 4860
aaattcatct ccatgagcca ggttacatat ttagggttta gcagagacac caccccccca 4920
tctatactct agccgttggg agcgacagcc cctcaaggcg gctgtcagat ggcattggac 4980
cacagtgagt ctcctgtgca tgggatttga ctagcaattg tagacatcga gggtgagatg 5040
ccatgtctgc taggcagagc tcaggagtca aggcaagtgc agaatcaggg tggcagggag 5100
atggggctgg aaagggttag gtgtcgcctg aggcaaggag gctggaggat aaggtggggt 5160
tgctaagccg ggcaccgagg ccctggctaa gctgtgagtt gtgctttgac cccagctacc 5220
cagagacctc acagcacaac cagacaacct cacagctttg aagggacagg gaccatgggt 5280
gttctttatt gggaggtata ccctgggtgg ccataaccgc agcctaccct tggtttcaac 5340
ctacagtctg cctggggctc tccacagagc tgggggcggg gcatggtact ccatccccat 5400
ccctgctacc tttctctggt tcacacacca tggacccagg ccctgcctcc tgggaaccac 5460
agccaagcat gaaccaaacc ccctaggcga tgtggctctc acagagcctt gctcccccag 5520
agcctccaac tcagaatacc actttacttc ctgttctgtg gccaaagcta aaccaggaag 5580
gctgagtagg gagggcaggt agcaggcaga gctctccaac ccccaaggcc cagcccagat 5640
cccatctcat gaccttatgg cttcttggca caagtcctgt gtgtcccagc cctgcctcag 5700
acccagactg gcctttccgt gaggactacc caagagacta ctttccagct cagtcctaag 5760
ctctgctcag gagcggaggc cagtgtttct cctcccaggt gtggtcacag ctggatagga 5820
actggctgaa tgacaccaca gctcaggtcc cacccactgc ctgacaagtg agaggagcca 5880
gcccccaggg gagcacccag aaggattcag ttaacaggga catctgtcag aagacctgag 5940
agggttagct ggggatggag aaggccaaga atgggaggcg gggcctctgt gggcagtgtc 6000
accttaaggc cacagtgggc agggatcagg atgggaccca aagtttagtt tctccaaata 6060
aatcattagg ctgacaccaa agtatcatcc cggcacccat ctgtcctggc atccatctgt 6120
ccactcttgt actcctcagc ctaacggaca gatcaacgct ttcctgagct cctccttctg 6180
acacgtgcag ccatcttccc atgaacccgt ttgcctctga ccattcatca tcctctgcct 6240
cccttccagc caactacccc catctatcta tcttgaccca ttggcaaatc catctttcca 6300
cctgtccatt gctccatcca aactgtctct ccaccccacc atcccagcat actataccta 6360
cgcccttaca ccttccagcc ccatgcacac aaccatgttc cctatcatct ctctattcac 6420
tgtactcaga gttctgtcag ctccatcagt gtaccaaaga caccaggtcc tcctacgccc 6480
tctactctgc ttggcctaaa ctgtccaggg ctgctctagg aatatctacc catgaggcaa 6540
caggcgtctc ccacccctgg cactctgccc caccatggtg ttcagatacc tccagaaata 6600
tgagttctta ccgtaggcat cgtgggcagg ttggatacat tcttgtggca gctgtgacac 6660
atctggagct gcttggggag agaagggaac aagaattgtg ctgtggggtg ggtctgtacg 6720
cctgctcacg agctctggaa gcctgggtta ggcagccacg ttccctgaaa ttagggcaaa 6780
gtccttgttt ccaggagtct gtccagaaga gagcaagcca gggctggcct cccttgacac 6840
cggggtgctc ttagtcccct gtgcccctgg acttttgtgc accattccca tcttctctgt 6900
taggatcccg aggagctcag agttggacct gtccggtctg cccctcctca atccacggat 6960
ggaaaggagt atttgctggg tgtttgggac cattcacaag tccccctggg aactccttgc 7020
tcatcctgaa gctcctacta tgtagggaag cttctgaaat gaggctgggc agagacccct 7080
gggtacccat catgctggca agaggaagag aagataggga gagaagcctg aggcgagctg 7140
ggctcagggg gactgtctat tcctggagac agctcacaga taaagcccag gacagtcaac 7200
caacaactcg cacaagtccc caaatcctag aaacctctgt cttgtgttct gttccttttc 7260
cttccgttca gctggccctt agggtaccaa gccagactgg gagacaggaa tgcagcatct 7320
gagtcaaagc atggcctgct cagcacatcc tcctgctccc aacccagaca agaggcccag 7380
gagccctcag ctcacaccat acctggggtg agcatagcat cacacagcct gcctggggag 7440
ccactgcttc tccccctaca ggagctggga ggagagtact ggatgttttg ttcatgaaaa 7500
gctgtgttcc atgccctaca catctatctg ggtgctgggt cccgccaccc acctctatct 7560
actgctgtcc tatatgtttg ccctgtgggc cacggatgtg gcgatcaggt taattacatc 7620
tgtgtaataa agtaagcatt tgctacgacg aaaaaaaaa 7659
<210> 11
<211> 7441
<212> DNA
<213> 智人
<400> 11
agagccgagg agccctgggg tccctcaaag tttgtgtctg gagccgtagc ggcaagtggg 60
cttgcggcta agggattttc ctgggatgag agcgggtctt ctgccttcat tttggatgca 120
catcccgctt tagccccggc agcctttggt ccggctcgtg tccctgggga ttctcggatc 180
tccgaggaca ccggacggga gcgcttggcc atcctctctc cggcagagga gcagacgttt 240
gctttccaag tgcaaaacta cagacacgcg cgcgcacaca cgcaagcaca cgcggagaga 300
gaggaacctt gccggtccga ggcagctctg cgcgtcccct cctgcgctta gcatcctcgg 360
cccagcgcgg cccgcaccgc catggaggtg ctggagagcg gggagcaggg cgtgctgcag 420
tgggaccgca agctgagcga gctgtcagag cccggggacg gcgaggccct catgtaccac 480
acgcacttct cagaacttct ggatgagttt tcccagaacg tcttgggtca gctcctgaat 540
gatcctttcc tctcagagaa gagtgtgtca atggaggtgg aaccttcccc gacgtccccg 600
gcgcctctca tccaggctga gcacagctac tccctgtgcg aggagcctcg ggcccagtcg 660
cccttcaccc acattaccac cagtgacagc ttcaatgacg atgaggtgga aagtgagaaa 720
tggtacctgt ctacagactt cccttcaaca tccatcaaga cagagccagt tacagacgaa 780
ccacccccag gactcgttcc gtctgtcact ctgaccatca cagccatctc caccccgttg 840
gaaaaggagg aacctcctct ggaaatgaac actggggttg attcctcgtg ccagaccatt 900
attcctaaaa ttaagctgga gcctcatgaa gtggatcagt ttctaaactt ctctcctaaa 960
gaagccccag tggaccacct gcatttgccg cccacccctc cgagcagtca cggcagtgac 1020
tcagagggca gcctgagtcc caacccacgc ctgcacccct tcagcctgcc tcagacccac 1080
agcccctcca gagctgcacc ccgggccccc tccgccctct ccagctcccc tctcctcacg 1140
gctcctcata aactgcaggg atcaggccct ctggtcctga cagaggagga gaagaggacc 1200
ctgatcgctg agggctatcc catccccacc aaattgcccc tgtcaaaatc agaggagaag 1260
gccctgaaga aaattcggag gaagatcaag aataagattt ctgctcagga aagtaggaga 1320
aagaagaaag aatacatgga cagcctggag aaaaaagtgg agtcttgttc aactgagaac 1380
ttggagcttc ggaagaaggt agaggttcta gagaacacta ataggactct ccttcagcaa 1440
ctccagaagc ttcagacttt ggtgatgggc aaggtttctc gaacctgcaa gttagctggc 1500
acgcagactg gcacctgcct catggttgtg gtgctgtgct ttgccgttgc attcggcagc 1560
ttctttcaag gctacgggcc ctatccttct gccaccaaga tggctctgcc cagccagcat 1620
tccctgcagg agccctacac agcctccgtg gtgagatcca gaaacctgct gatctacgag 1680
gaacattctc ccccagagga gtcatccagc ccgggctcgg ctggggagct ggggggctgg 1740
gatagaggtt cctccctgct cagggtgtca gggctggagt ccaggccgga tgtggatctt 1800
ccccatttca ttatctcgaa tgagaccagc ctggagaagt cagtgctttt ggagctgcag 1860
cagcacctgg tcagcgccaa actggagggg aatgaaacac taaaagttgt agaactcgac 1920
agaagagtga acaccacttt ctaaagaggc tgcctgcacc ccctcccttt cccttaactc 1980
tacttttaca tccccaaacc acctttgtca tcagcttttc ctctttgcca ctggatcttc 2040
atggagacat gggcaagcat tagtggcttc agattggaga ccagcctggg acttccctgc 2100
agtgagagag catctccccc tggtccatgc ccctcctgtg cagaagggag cctgcatccc 2160
tcccttcctt tctcttactg ccataggaaa ttattttagg ggttggaggt gggacaagca 2220
ggcttgtttc caccaatagt gccaaaaaga tattgcctaa tgtgcacctg tgaggtgtaa 2280
ccccccgctt tggagacgag atggctcttg ttcagtcaag accccagact ctggccacaa 2340
aaatgccata atgcctgttg gtatttggca aagcactgac ccgtgtcctc cgttgctcgc 2400
actggggtct ctggtgtgaa cacccccgac agcagccctc cgcccactct gccccctggg 2460
agccctcgct ggatcgtctc gtctcctgca gcagcactgg caggcgaggg ctctcgttca 2520
tattctcagg ccgcaagtgc aatgcctgag gggatcaggc ttttctactc caggcaaacc 2580
tgccccatct tgtcgctttt aggacctccc acaacctggt tccccacaca tccatagttc 2640
tgcctcccca gcttctcctc cccagttgta aatagtattt attagcttgc cgaggcttcc 2700
tgctagcaac cacactgaag agatcgatgc ctcctttcaa gctagccaag ttttctgcga 2760
gccttcagag ctaggagggc accctaggct ctgggatccc gtgtctttcc agacaatgtt 2820
ttgtttcctt tcctttgttt tttcttttaa ctggaataat taccattgaa aaagaagttc 2880
ctttgagcat gtatgtgtct gcctctagga tgagctcaga gcgagagatg acacaatgcc 2940
tcactcaggc cccgggctcc ctggccacaa gctttttcta tcctgttttc atgacagaga 3000
aggggaagcc ctgttctgac aacagacatt tcagacaacc ttgctggctt tccacacctg 3060
cctggccccc tcctccctcc acacttccac tttgtcctcc tcgtccccta cctcaacaaa 3120
gcagggtggg gtaggtgaca tttgtgtatc cacattctta cctttggtag tcaggtttgg 3180
ctactttgca gctcgcccaa agagatacaa cctaatcccc aacctacttt tagttttttt 3240
gttttttttt tatggttaaa agtaactttt gtagtttaaa aaaatctttc ctctttcata 3300
taaataagaa gtggaaattg cctttttatt gtgtaatgta gaaaaccctc aagtgttttt 3360
tccgagcttg ggaaagattt tgtgtaggaa atgtgcatag agtttgtatt ttatttttat 3420
tagcagctga aatgcctttg gttttggctt ctctctctcc ctctctctct ctgtctctcc 3480
ttctctctct ccccccacca cccaccccca cacacgtcat ctgcattgtt attggagcct 3540
gtacttagag ggattaagcc cacaccctgg cttccattcc atatcaggta caggatttga 3600
tgttattaac atttgtcgtc atacctcata agtcggtccc tgccttgtct gtctaggccc 3660
atttggggct ccctgtgagt gattcccctc tctctgctat gctggagacg gttccagcct 3720
ggaaagcggc caagttcatc ttctcactgt gagtggaagc tggatcgggc ccccgtagtc 3780
ctggcagccc tgttgtctgg agggttcttg ttgtccctcc cattagccag ggcggagact 3840
gtctgagctg tgcaggagga gggttgctag taggttctgc ttctgcttct ctctgctcca 3900
ctgtctgcag cccagatcct gttgggcctg gctggtgtct ggtaaccatg ggcctccact 3960
gacccatccc tctcttttaa actgtcaggt cattatcagg cataggcagc ctatagggcc 4020
caaagaaggc aaaaagataa gatttactca agtagcattt gggcaatgag gaaggaaagg 4080
tttcaaattt aggggcagaa gtgagagaat gagccaaccc atgtacctgc tgcaactgaa 4140
ccagactggg ttttcaaggc tcccagacgt agagtaggaa acgtgctctt ctaaatgagg 4200
agggagaaga taaaggaaac ttctagcccc tgtccttagt gctttgagga ttttattttc 4260
tcccttacta cgcttgcttg acgtcactct ctctcgacct ccaaacagca ggactctttc 4320
tctgggaaac catccttcca aaacggaatc tatgtagaca atgggacgtt aggcagagag 4380
ctcagatggc ccttttaagg gggctccaag aaccaacatc actgctcttt tagataaacc 4440
tctgccctcc actccttgct tgagtgggtt aaaggaacta acagttgtcc ctttaggagg 4500
acaaaatggg gtcaagagga cacagaagag ttgtatagca ccagattggt tccaaatagt 4560
taatggatgt gtgcacattt tctgttcagg gattaagacc agaatatcag tggatttgtt 4620
ttccccacca agtggcctct tagactagtc attaacttat gattagctct aaagatttca 4680
aatagtggca gacagtgtct tctgaatgta agttttgaga aatacgagtc tgtcagagcg 4740
gccataagcc ataaagagtc aatctcttaa ttatattttt catcatgtaa acaagtttcc 4800
catttccctt tcttagattg caccagtgaa ggagatgttt tgcaaagatt cagagaacta 4860
atttttcact ggataagacc tgagtaaccc agacccccca ccgtggttct tttcacagcc 4920
ctcgactttg cacttaaaaa gggatattgt aaatgaaagg ctgcagtgcc agttttaaga 4980
aagaatttct gtgaagtgtg aggactctgg agtctagctc acataaagag agtgttatat 5040
aaaaatccga cagctgaact aggttgctct tttttggcag ggagtgggga tgagatttga 5100
caccaatatg ggcaaaatta gataaccttt tggttaatat aaatgatttt gatttggagg 5160
cctaatttgt agattgtgaa agcagctttt agtttaactt attcacagac cccttataat 5220
taccatgttt ttttttttct tcctaaatct cttggttcag cttgtgaatc ttacgtgccc 5280
gtaaagttgg gatgttgaat tggctcttct ttgttctggc agtgagtcaa gtgtccagca 5340
ttttttcata agtgtttttt aaaattgttc tccagcattt tatggctcct ccctcccatg 5400
tcctcagacc cagcaaaagc gtagaggcag aattagaggc ctctccaggc cagctcctct 5460
gcccacatgt catacaaggt gtgaatttga gcacagtcca gaaatggaga catcccaccc 5520
ccagttgaat aatggcccat tcatgccaac cttgccaaca cggagagggc agagatgcac 5580
tagaagacct tcatcctccc cttcctctgc cccaagtcac tacagttggt tctattgaag 5640
ccagtcttta agaaacctgg gttaaagaca ccagcacttc tgcttgctgg gctggctgga 5700
cctgtgaagc catgggcagg tagtgccctc ttgagagtca ttttatttgg ccaccttcag 5760
gtgagactat ccatagacac atgctaggat aggccccgct gggagggcag ttacaggaga 5820
gagtaggtgg tggtgacgtg agggctgtga aggatccaga gacaagactt agatgtttcg 5880
ttcattcact cactcattca gttactccta agacttttca gtttcataag gaagagtgtt 5940
gcctgaggcc ctagggaata ttggggaata gaagggattg aggaaacatt aataatagtt 6000
attcaaaaga cccaaatgct tatacttctc tctcccttct tctctctctg acacacacac 6060
acacacacac acacacacac acacacacgt gcacattcct cccttacatg ctcatttgtg 6120
ccttaaatgt gccttatagg taaatccagg atgactgagg aatccctcgt cactgggaga 6180
ttttgtatat attcttttat tattagattg agttgggtgt ggggaaaaat ttttttctga 6240
aggctcaaaa gtggtttcct aaaagtgagc cactatcaga tttgcacatc aggagaaaag 6300
aaatagggtt acgtccatta ggaaaatccc agtttgcagg agtgcaatca catcaaaaaa 6360
acaaccagcc aggattaaag gtattataaa tcctcatagc ggaacatttc tcagggcaaa 6420
ggaacctggc tcatttgaag attaatgttc catgcctttg tggtcaaagg gtcagcactt 6480
aacacaggaa aaaactaggt gttgttttgt tttgttattt tggacaacat aaaattcagg 6540
aatgttttat ttagccttgg tttctagaag gaagggaaat aatatttctt gagcatttac 6600
tagggtgttg cgtgctgtgc taagtaaatt ttaagtcttt cagttttata gatacggaaa 6660
acaagggtga ctctttacca caggatgaat aaagaactaa gtaatatggg aaatgcagca 6720
atttctggac tagctgagcc gattccttcc tgtgagcaca ctgtaagctt tcaagttctc 6780
tgggcaggaa ttacagcacc tgtcccctgc aatggccctg ctgtgtgatg ctcatcgctt 6840
cccttcgtgc tggagcagtc ccccaggtgt ccatctccta tctttttgtt ccaatcttct 6900
gtgagttcca gctagcaggc tttacatctg gggaaaggaa aaccaggggt tttagctctg 6960
ttctctgctc ccatccttcg ctcaccagct gagtgagaac atgaactttt tgcaccatgt 7020
acccatggct tacactactt agaaaatcac cttttcagat aaaacagttt atgagttcat 7080
agagaacacc agcactcttt gacaaaactg tgagtgaccc tttttaaaca atgctgagca 7140
ggccctgagc tataatcaac ggtgagcttt aatgtctatg ctgacagtta ggttttgctc 7200
tcttttgtaa caggttacgt agaccagcag tgtttaaatc taaatacgtt gtgagtctgt 7260
tatctgtcct atcgcgtttt ttaaatgact ttttattctt tatcatagct aagtaaatac 7320
caaaaaaaaa aaaaagcttt gtaggacact tgtacttagt ttgggaaaaa aaaataaatt 7380
gaaattgtta tgcttttgta tttccatttc ttgcaaataa atattttttc ttaaatagta 7440
a 7441
<210> 12
<211> 3318
<212> DNA
<213> 小家鼠
<400> 12
gggagtctca aagtttgtct ggagccctag tggggagtgg gcttgttgcg cgaggacttt 60
cttgggatga gcgctgcctt tttgccttcc ttttggatgc acagcccgat ttaacccctg 120
caccttccgc ccgatcccag caggcttgtc ctccccgggg agtcacagat ttccgaggac 180
aagggtcgcg tagccttcgg cagggctctc ccgagttcct gctccagtgc ataagttcca 240
cgcgcgcaca cgccaagtac acggggagaa gcgtctcacc ggcccgcggc ggctctgcgc 300
ggtcccctcc tgcctcagca tcctcggccc tgcgcggcgc ccaccgccat ggaggtgctg 360
gagagcgggg agcagagcgt cctgcagtgg gaccgcaagc tgagcgagct gtcagagccc 420
ggagagactg aggccctcat gtaccacacg cacttctcgg agctcctaga cgagttttcc 480
cagaacgtcc tgggtcagct cctgagtgac cctttcctct cagagaagag cgagtcaatg 540
gaggtggagc catctccaac atcaccagcg cctctcatcc aggctgaaca cagctactct 600
ctgagcgagg agccccggac tcagtcacca tttacccatg cggctaccag cgacagcttc 660
aatgacgagg aggtggagag tgaaaaatgg tacctgtcta cagagtttcc ttcagctacc 720
atcaagacag agccaatcac agaggagcag cccccgggac ttgtcccttc tgtcactctg 780
accatcacag ccatttccac tccttttgaa aaagaagagt cccctctgga tatgaatgct 840
gggggggact cctcatgcca gacgcttatt cctaagatta agctggagcc gcacgaagtg 900
gatcagttct taaacttctc cccgaaagaa gcctccgtgg atcaactgca cttaccacca 960
acaccaccca gtagtcacag cagtgactct gagggcagct tgagccccaa cccacgcctg 1020
catcccttca gcctgtctca ggcccacagc cctgccagag ccatgccccg gggcccctct 1080
gccttgtcca catctcctct cctcacagct ccacataagc tgcagggatc gggccccctg 1140
gtcctgacag aagaggagaa gaggaccctg gttgccgagg gctatcccat tcccaccaag 1200
ctgcctctga caaaatctga ggagaaggcc ctgaagaaaa tccggagaaa gatcaagaat 1260
aagatttctg cccaagaaag caggagaaag aagaaagaat acatggacag cctggagaaa 1320
aaagtggagt cttgttcaac tgagaacttg gagcttcgga agaaggtgga ggtgctggag 1380
aacaccaata ggactctcct tcagcaactt cagaagcttc agactttggt gatggggaag 1440
gtctctcgaa cctgcaagtt agctggcaca cagactggca cctgcctcat ggtcgttgtg 1500
ctttgctttg ctgttgcatt tggaagcttc tttcaaggct atgggcctta tccttctgcc 1560
accaagatgg ctctgcccag ccagcatcct ctgtcagagc catacacagc ctccgtggtg 1620
agatccagga acctgctaat ctatgaggaa cacgctcccc tggaagagtc gtcgagccca 1680
gcctcagccg gggagctggg gggctgggac agaggctcct ctctgctcag ggcatcgtcg 1740
gggcttgagg ccctgccaga ggtggatctt ccccatttcc ttatctccaa tgagacgagc 1800
ttggagaagt cagtactgtt ggagcttcag cagcacctgg tcagcagcaa actggaaggg 1860
aacgaaacac tcaaggttgt agagctggag aggagagtga acgccacctt ctgaggagag 1920
ctccaccctc ctcttctcct aactccatct gatcgtcctt tcagtttccc cttcaccact 1980
ggatctcgag gaggagatgg cctagtgtta cggctcgaga caggaggcca gcccaggggg 2040
ttctgcttat gtgtccccgt ggctctccac aaaagggagc tagcacctct ccatcccttt 2100
ctcttactgc cattggaaat tattttaggg ctgagatagg ggtggaacga gcaggcttgt 2160
ttccaccaat agtgccaaga agacactgcc tgattcttcc ccgggaggag tgactcctct 2220
gaagaagaca tgactcatgt tcagttgaga ccccagactc tagccacaca catgccacag 2280
acatgccagg gagtggcaaa gcactgactc ctgagctccc ttcctcacta ggactccagt 2340
gtgaccctgc actgagagga ccaaagcgtc attgcagtct tctctccacc ctgtaccccg 2400
gagtcctgat tggatgtctg cagaggcaga tggggctccc accatatttt caggccgcaa 2460
gtgcaattcc tgaaggcatc aggctcttct ctcccaggct ctcctgccca ctgtgttgtt 2520
tgtaggacac ccccacaccc actcatacac agcctgcatc tccacaggac aatagctctg 2580
tctccctggc ctcccctccc catttgtaaa tagtatttat tagcttgctc aagctcccag 2640
ctggccatag tgaaaagatt tcccctttca accagcaaag tcttctgttg gcctttggaa 2700
caggagagtc cccggaatct aggaccctag tctttgtact tgatgccttg tttcccccct 2760
tttcttcttt aaaattgggg acctataaca tcatcgctgt tgcggaatcc acttaggcat 2820
gtgtcccctg atggatgaat acatgggaat ggtggatact gtcttctgac tcaggctcta 2880
ggctccatgg cttcctctct ctggtcctgc cacacagaag gaaagccctg tccaggataa 2940
tgagcgttgc tgacaccctt gctagcttgt cctgcctacc tgcttacccc actccctcac 3000
cttcctcctt cccttctgcc ctccatccac ctgccttaac taattggggc tggagttggt 3060
catttttgta cacccacagt ggtacctttt acagtcaggt ttggatactt tgcagctcat 3120
ccaaagagac ataactaaac cctaaactct ttttttgttg ttgttgttgt tgtttttttt 3180
ttttatgatt aaaaagtaaa aattgtagtt taaaaaatcc tttcctcttt catacaaata 3240
agaaatggaa attgctcgtt tattgtataa gatagaagat tcgtttaaag tgtttcccca 3300
cccccacccc cagcttgt 3318
<210> 13
<211> 5139
<212> DNA
<213> 智人
<400> 13
agttggaaag agaccacaga ctttgaggga agctcactca ggatctgctc tccggcaaag 60
tagtaagtga ggtgctgaga gcagaatgag ctactttgtg gattctgctg ggagcagccc 120
cgtcccttac tcagcgcctc gtcctgcagt ggtgaggcaa ggacctagca acacttatga 180
agatcctcga atgaactgtg gtttccagtc caattatcac cagcaaagac cttgctaccc 240
cttttgggat gagatggcaa ctcaggaagt tcctactggt cttgaacact gtgtctcaga 300
tatggaatgt gcagatgtcc cactattaac tccaagcagc aaagaaatga tgtctcaagc 360
attaaaagct actttcagtg gtttcactaa agaacagcaa cgactgggga tcccaaaaga 420
cccccggcag tggacagaaa cccatgttcg ggactgggtg atgtgggctg tgaatgaatt 480
cagcctgaaa ggtgtagact tccagaagtt ctgtatgaat ggagcagccc tctgcgccct 540
gggtaaagac tgctttctcg agctggcccc agactttgtt ggggacatct tatgggaaca 600
tctagagatc ctgcagaaag aggatgtgaa accatatcaa gttaatggag tcaacccagc 660
ctatccagaa tcccgctata cctcggatta cttcattagc tatggtattg agcatgccca 720
gtgtgttcca ccatcggagt tctcagagcc cagcttcatc acagagtcct atcagacgct 780
ccatcccatc agctcggaag agctcctctc cctcaagtat gagaatgact acccctcggt 840
cattctccga gaccctctcc agacagacac cttgcagaat gactactttg ctatcaaaca 900
agaagtcgtc accccagaca acatgtgcat ggggaggacc agtcgtggta aactcggggg 960
ccaggactct tttgaaagca tagagagcta cgatagttgt gatcgcctca cccagtcctg 1020
gagcagccag tcatctttca acagcctgca gcgtgttccc tcctatgaca gcttcgactc 1080
agaggactat ccggctgccc tgcccaacca caagcccaag ggcaccttca aggactatgt 1140
gcgggaccgt gctgacctca ataaggacaa gcctgtcatt cctgctgctg ccctagctgg 1200
ctacacaggc agtggaccaa tccagctatg gcagtttctt ctggaattac tcactgataa 1260
atcctgtcag tcttttatca gctggacagg agatggctgg gaattcaaac tttctgaccc 1320
agatgaggtg gccaggagat ggggaaagag gaaaaacaaa cctaagatga attatgagaa 1380
actgagccgt ggcctacgct actattacga caaaaacatc atccacaaga cagcggggaa 1440
acgctacgtg taccgctttg tgtgtgacct gcagagcctg ctggggtaca cccctgagga 1500
gctgcacgcc atgctggacg tcaagccaga tgccgacgag tgatggcact gaaggggctg 1560
gggaaaccct gctgagacct tccaaggaca gccgtgttgg ttggactctg aattttgaat 1620
tgttattcta ttttttattt tccagaactc attttttacc ttcaggggtg ggagctaagt 1680
cagttgcagc tgtaatcaat tgtgcgcagt tgggaaagga aagccaggac ttgtggggtg 1740
ggtgggacca gaaattcttg agcaaatttt caggagaggg agaagggcct tctcagaagc 1800
ttgaaggctc tggcttaaca gagaaagaga ctaatgtgtc caatcatttt taaaaatcat 1860
ccatgaaaaa gtgtcttgag ttgtggaccc attagcaagt gacattgtca catcagaact 1920
catgaaactg atgtaaggca attaatttgc ttctgttttt aggtctggga gggcaaaaaa 1980
gaggtgggtg ggatgaaaca tgttttgggg ggggatgcac tgaaaatctg agaactattt 2040
acctatcact ctagttttga agcaaagatg gacttcagtg gggaggggcc aaaaccgttg 2100
ttgtgttaaa atttatttta ttaaattttg tgccagtatt ttttttctta aaaatcgtct 2160
taagctctaa ggtggtctca gtattgcaat atcatgtaag tttgttttta tttgccggct 2220
gaggattctg tcacaatgaa agaaaactgt ttatatagac cccattggaa aagcaaaacg 2280
ctctcactga gatcagggat cccaaattca tgggacttat ataagaagga caattaatgc 2340
tgatttgggt acaggggaat tatgtgtgtg aatgtcatct acaattaaaa aaaattagca 2400
catcccttta cttacttgtt atcagtggat tctcggggtt tggacttaat gttgagctaa 2460
gaagcattaa gtctttgaac tgaatgtatt ttgcatccct ggttttggac gacagtaaac 2520
gtaggagcac tgttgaagtc ctggaaggga gatcgaagga ggaagattga cttggttctt 2580
tcttagtcct atatctgtag catagatgac ttggaataaa agctgtatgc atgggcatta 2640
cccctcaggt cctaagaaat aagtcctgaa tgcatgtcgt tccaaactaa cactctgtaa 2700
tttttctttt atgtcttatt ttccaagagt cctccatttt ttgcaccccc tcaccgccaa 2760
ctctgttatt cagtagagag aagtgtacgg ctttctgatt ggtgagtgaa aaagtaactt 2820
gagacacgac ctaagttgaa gagtttagac ttgctgagtt ttagaagtga tggaaattaa 2880
gagagcattt caataaaatg tgacttggct gtctttggaa gagaagtgca aggctttcct 2940
ttgaagaatt taaattagtc cggtaggatg tcaggtgaga ctgtgtatgc aaaatgaatg 3000
gcacaggtga tgccagggcc tcttgcttgg gtctgatgtc ttggcacagg gtaagtgaag 3060
gttaattcca gaagagagga atgacttgaa ggcaaaggaa actaaggaag gaggttcagt 3120
gaggaaaata aggttgtcca tgagatttga atagattttt agttccccca aggtttaaat 3180
acaaacatag tcaagcaagg tagtcatctt tctgctggtt gtgaggggga atctgaaaat 3240
ggagttttag aggaaaagtc aacatctaac tagtgaggaa aagtgcctaa tacaattaga 3300
atctccctca ctctatagtt gcccagttga aaggataagg aggaggggtg gcttttatgg 3360
acttccatga gagaaggaaa gaaatatttc aggtaagctt ctcagggctg gccctttttg 3420
ggatttggat gagaaattgg aagtactaac tactttctag catatcttta agaaaattga 3480
ttgttattta ctcccagatc ctcttgcaga cccagaatta tcaggaacat agctctgtga 3540
ttcatgagtg tccccatact gatgaattgg agcatccata tggaaagcaa aggcagaatt 3600
atcccagctg tattattttg atcttttgga tgcaggtgcc ttaatgaagc tctcaaaata 3660
ttttaggagc tgctcaggga gtgttgggtg gaactgtttg gactacattg ttttctctta 3720
gattatgtga tttttgttgg gcactggcaa aaggtgtgtg tgtgaatgtg tgcatgtgtg 3780
tgaatgttgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtttgcagac 3840
atgcaaaact gcagctgaaa taatacctta gatttctagg taagtctttc cacatttcaa 3900
taatgggtaa gagtagaacc agggccgggt atcaattatt gcttgctgtt tgcaaccagg 3960
cataaaatca ctttctcaaa tcatccaccg ttcctattaa atttatgccg gaaactctcc 4020
ttctgtgagt ataactcctg cagttcctat agcagataag atataagaaa gtgcctccta 4080
gtgctcctcc gcccgcttgt ttgctaaaat tccctttctc tctaagtcca ccattttcaa 4140
gatttgtaga tagtgtatta gttaagacag ctttgtcgat ctggccagat gttttttctc 4200
ctttgtccaa aggccagaga ccatcccagg aagagtggtg ggtggtttat acactggaaa 4260
tgttgcgttt atgcttttta aaaacacacg ttaacttcag aggaaggatg ggcaaatctg 4320
gtctagctgg gtgaaaccct tattttccca gagatgcctt aacctttgtt ggttttggct 4380
ttagggttca gagtcacttt tgttcccttc tccattctgg agagggactt cccctacata 4440
gagccctgat ttttgtggct gtggggattg gaggtagcat tcaaagatca gatgtgcttt 4500
tcctcacttt ggagatgaac actctgggtt ttacagcatt aacctgccta accttcatgg 4560
tgagaaatac accatctctc ttctagtcat gctgtgcatg ccgcttactc tgttggggtc 4620
tatataaatt tgttgaactc ttacctacat tccaaagaag tttcaaggaa ccataaatat 4680
atgtatacat atacatatat aaaatatata tattaaaata aaattatcag gaatactgcc 4740
tcagttattg aacttttttt tttaagaata cttttttttt aagctgagaa gtatagggat 4800
gaaaaagatg ttatattgtg tttgactatt ttccaacttg tattttcata taatttatat 4860
tttttaaaag ctgaaaattt agaagcaaga tgaaaaaaag gaaaagcagg tgctttttaa 4920
aaatcagaac tgaggtagct tagagatgta gcgatgtaag tgtcgatgtt tttttaaaaa 4980
aaaatgcaaa aaaattctta tggcggagtt ttttgtttgt ttattttagt agctgatgct 5040
ggcacatcat tttgctggag agttttttat atactgtagc ctgatttcat attgtatttt 5100
aaactgtgtg aaattaaaaa caaagaattt cattcataa 5139
<210> 14
<211> 5065
<212> DNA
<213> 小家鼠
<400> 14
taaagcggag gcgagctgca ctgcgccagc gccggccagc cgtgcgagcg agcaagggag 60
cgagcgcccc ggacggagga gggagcgagc gcccgggaca gaggagcgag cgggcgggcg 120
aggcgcgggc gaggctggga cctaagcgcg ctctctgctc cgccaagtgc caacttcgcg 180
cggactggct gggcgcgcac cttcccgcgg ggcggtcagc gggaatttga gattttaggg 240
ttgcgctctg tccccttcca ctgggttcaa aaatccccat taaaaagcaa aacaacagtt 300
acagcaaact tactctcatc ccgccggccc cctcaactcc gggcaccatg aaggcggccg 360
tcgatctcaa gccgactctc accatcatca agacagaaaa agtggatctc gagcttttcc 420
cttccccgga catggaatgt gcagatgtcc cgctgttaac tccgagcagc aaagaaatga 480
tgtcccaagc cttgaaagct actttcagtg gtttcacaaa agaacagcag cgactgggaa 540
tccccaaaga cccccggcag tggacagaaa cccacgtccg ggactgggtg atgtgggctg 600
tgaatgagtt cagcctgaaa ggtgtggact tccagaagtt ctgtatgagt ggagcagcac 660
tgtgtgccct gggtaaagaa tgcttcctcg agctggctcc agactttgtt ggggatatcc 720
tgtgggagca tctagagatc ctgcagaaag aggatgtgaa accatatcag gttaatggag 780
ccaaccctac ctacccagaa tcctgttaca cctcggatta cttcatcagc tacggtatcg 840
agcatgctca gtgtgttcct ccctcagagt tctcagagcc cagcttcatc acagagtcct 900
atcagacgct gcatcctatc agctcggaag aactcctgtc cctcaagtat gagaacgact 960
acccttctgt cattctccag gaccctctcc agacagacac cttgcagaca gactactttg 1020
ccatcaagca agaggtgtta actccagaca acatgtgcct ggggagagcc agtcgtggta 1080
aactcggggg ccaggactct tttgagagcg tagagagcta cgatagttgt gaccgcctca 1140
cccagtcctg gagcagccag tcatccttca acagcctgca gcgggtcccc tcctatgaca 1200
gcttcgacta cgaggattat cccgctgccc tgcccaacca caagcccaag ggcaccttca 1260
aggactatgt gcgtgaccgt gctgacctca acaaggacaa gcctgtcatt cctgctgctg 1320
ccctggctgg ctacacagga agtgggccga tccagctgtg gcagtttctt ctggaattac 1380
tcactgataa gtcttgtcag tcctttatca gctggacagg agatggctgg gaattcaagc 1440
tttctgaccc agatgaggtg gccaggagat ggggaaagag gaaaaacaaa cctaagatga 1500
attatgagaa actgagccgt ggccttcgct actattatga caaaaatatc atccacaaga 1560
cggcgggcaa gcgctacgta taccgctttg tgtgcgacct gcagagcctg ctgggataca 1620
cccctgaaga gctgcacgcc atgctggatg taaagccgga tgctgactag tcatggacag 1680
acgcgcagaa ggaaggggct gggggaaccc tgctgagacc tttcaaagag caaccctgtt 1740
ggttggactc ttcattttta attgttattc aatgttttat tttccagaac tcatttttca 1800
cattcagggg tgggagctga gggagcgccg ctgtattcca ttggccattg gtgggccgga 1860
aagaggaggt caggacctgc ggggtgggcg gggcaatagc tcctgagcag actttcagaa 1920
gggagaggtc ttctcagaag cctgttggac ctggcttgca gaggaaaaaa aaacttaagt 1980
gtccgttttt tttttttttt tttttaaatc aaagaaaaaa aaattcatct tgagttgtgg 2040
atctactagt gggaggaatg atcacattga gatgaaagag attgatgaaa gccagtcagt 2100
tttgtgggtg ggctgaaaac agtttcttca ggggattact aaactcaaga attattaacc 2160
tttctacttt ttgaaacaat gatggacttt gattgaaggg gtccaaaact gtttttatgt 2220
tgaagtttat tttattaaat tttgtgccag tatttttttt tccttaaaaa aatatcgtct 2280
taagctctaa ggtggtctca gtattgcagt attgtgagtt tgttgttatt tgctggctga 2340
ggactcttgt cacagtgaaa gacaactgtt tatatagacc ccattggaaa aatcccagtt 2400
ctgtactgag atcagagacc ccaaactctt acagctaaag gaaacgaatg ctgatctggg 2460
gacaggggga ctgtgcgtgt gacttccacc tgcggtttgt aaaaactgtt ttcctttgat 2520
tcactgtcag gctttggact tagtgttagt tacggggcgt taagtctctg cactgaatgt 2580
attctgcagc tcttctatgg aatcgtcggc atcatagcac agttcaagtc ttggaaacga 2640
aatccaagga gcaggattaa cctgggtttt ggttaaaccg ctacccgaaa catggaagac 2700
tcagaataaa agccgtttgc atgggcatta ccccgagggt cttaaggcct caatgcatgc 2760
cattccaaac taacattctc agttctcctc tactttgtct tatgttcccc ccggcatccc 2820
tcattgctgc ccctccctca tcactgatca gtgaaagtgg agtgtaatgc atcctgacac 2880
gtgactgaaa gtgtagtttc agccatcaca acacaaatcc aagagtccag acttgctagg 2940
gctcggaggc cacggcagtg gagagggtat ttcagtagca tgtgactcgg cctcctttga 3000
agacttggtg ctcgtcaggt aggatttcag gtgagactgc ttgccgggaa gtggcaggga 3060
gcactggcac ttgacctgtt accacctcag cagagggcaa gcccaggtca actgcggtga 3120
gagggagacg gagaaaatac aagggaaggc gcttaggtaa ggaaaataag gtggcccgag 3180
acagttagat agatgtttag tttcctccaa gtttaaactc agacttaatt gaggcagcca 3240
tcatcctgcc tgatgggaga ggagacctga aaataagcca ttgtgggtta aaaaaaaaag 3300
taaggagaca tgcctgggat cattagaatc ccttccactg tatagctgcc tagttaagac 3360
agtgacagtg acatccctga gagaagagag gcaattggct gaggtgggcc tctccaggct 3420
cacccttcgg ggtttgtagc tccctggtat catcttccag gagagttgat ggctgactcc 3480
cacattccct tgaagactct gaattactaa gactataact cttgtccgtg ggtgttctgt 3540
actgactgag tggagcatcc ccacaaggaa gcaaaggcca aacattccag ctatatattt 3600
tgatcttaca aatgcaggtg ccttaatgaa gctctcaaaa tatttaggag ctgctcaggg 3660
agtgttaggt gggatcattt ggattatgct gttttctctt atgttatgtg atctttgttg 3720
ggcactgaca gtgtgagtgt gtgtgtgtgt gtgtgtgtac atttgtataa agttgcagct 3780
gaaatagtac tgaattttct acttagagtc tgttcacatt tccataatgg tgaatgaaag 3840
agtacagccg gggctggtat tgttgtttgc tctttgcaac agggcttaaa aaaatcactt 3900
ccccaagtct tcacccttct ccatattggg ttcctgctgg gaatgcccct cctgagagcc 3960
taccacctgc agtcccctag cagagaagac ataagaaagt gtctcccaca ctcctcagcg 4020
tgctgacttg cctgccttga tgccctttct ccctaggtcc accacttttc aggatttgta 4080
gatagtatat tagtcagaca gctttgttgt ccatctggcc agatgctttc ccccatctcc 4140
tccgaaggcc agagaccatc ccaggaagag tggcgggtgg tttatacact ggaaatgtag 4200
cagcattgct gcattgatgc tcttttaaaa cacgttcact tcacaggaag gatgaacaga 4260
tctgacctag ctgggcgact ccatcatttt cccagagaaa tgctttaacc tgtgtggctg 4320
gctttgggct cagaggcggg gctaaggatg ctccctgcgg agagctctga tggtgtggcc 4380
atggagacct tgtaagcatt caggatcaga gatgctcttc ctcactttgg agaccagcac 4440
tctgggtttt aaagcattaa ccttcatggt gaaatcacac cttctctctc ctagccatgc 4500
tgtgcatgcg gccttctctg ttggggtcta tataaacctg ttgaactctt acgtacattc 4560
caaagacgtt tcaaggaacc acaagtatat gtatacaaat acatatatga agtatatatg 4620
ttaaagtgaa tttatctcta tcaggaatac tgcctcagtt attgaatttt ttttaaggat 4680
actttttttt ttaaagctga gaattattga ggtgaaaaag atgttatatt gtgtttgact 4740
ttttccaact tgtattttca tataatttat attttttaaa tgctgaaaat ttaaaagcaa 4800
gatttaaaaa ggaaaagcag gtgcttttta aaaatcagaa ctgaggtagc ttagagatgt 4860
agcgatgtaa gtgtcttaaa tgttttttgt ttttttttta aaaacaaatg caaaaaattc 4920
ttatggggga gtttttggtt tgtttcattt aagtagctga tgctggcaca tcattttgct 4980
ggaaaatttt ttatatactg taggctgatt tcatattgta ttttaaactg tgtgaaatta 5040
aagaaacaaa gaaattcatt cataa 5065
<210> 15
<211> 5322
<212> DNA
<213> 智人
<400> 15
gttgttgttg gtggcggcgg cgagcggagc cggaggagcc gccgcaaaga tggaggagcc 60
gtcgaggagg tgctgccgcc gctgccgccg ccgctgctgc cgccgccgcc cgcgaagccg 120
gagctcgagc cgcagcgggg atgccgttct gagtgcctga ctgcctcgcc ccgaaggatg 180
gcctcggatg ggcattagag gcacggcggc cccgggctcc cgtcccgtcc gtctgtctgt 240
tatcgtctgt ctctcttgac atcaccgcag ctccaccccc tcccgtccca gcccccaacg 300
ccagcttcct gcaggcccag agccggcatg aactctccca acgagtcggc agatgggatg 360
tcaggtcggg aaccatcctt ggaaatcctg ccgcggactt ctctgcacag catccctgtg 420
acagtggagg tgaagccggt gctgccaaga gccatgccca gttccatggg gggtgggggt 480
ggaggcagcc ccagccctgt ggagctacgg ggggctctgg tgggctctgt ggaccccaca 540
ctgcgggagc agcaactgca gcaggagctc ctggcgctca agcagcagca gcagctgcag 600
aagcagctcc tgttcgctga gttccagaaa cagcatgacc acctgacaag gcagcatgag 660
gtccagctgc agaagcacct caagcagcag caggagatgc tggcagccaa gcagcagcag 720
gagatgctgg cagccaagcg gcagcaggag ctggagcagc agcggcagcg ggagcagcag 780
cggcaggaag agctggagaa gcagcggctg gagcagcagc tgctcatcct gcggaacaag 840
gagaagagca aagagagtgc cattgccagc actgaggtaa agctgaggct ccaggaattc 900
ctcttgtcga agtcaaagga gcccacacca ggcggcctca accattccct cccacagcac 960
cccaaatgct ggggagccca ccatgcttct ttggaccaga gttcccctcc ccagagcggc 1020
ccccctggga cgcctccctc ctacaaactg cctttgcctg ggccctacga cagtcgagac 1080
gacttccccc tccgcaaaac agcctctgaa cccaacttga aagtgcgttc aaggctaaaa 1140
cagaaggtgg ctgagcggag aagcagtccc ctcctgcgtc gcaaggatgg gactgttatt 1200
agcaccttta agaagagagc tgttgagatc acaggtgccg ggcctggggc gtcgtccgtg 1260
tgtaacagcg cacccggctc cggccccagc tctcccaaca gctcccacag caccatcgct 1320
gagaatggct ttactggctc agtccccaac atccccactg agatgctccc tcagcaccga 1380
gccctccctc tggacagctc ccccaaccag ttcagcctct acacgtctcc ttctctgccc 1440
aacatctccc tagggctgca ggccacggtc actgtcacca actcacacct cactgcctcc 1500
ccgaagctgt cgacacagca ggaggccgag aggcaggccc tccagtccct gcggcagggt 1560
ggcacgctga ccggcaagtt catgagcaca tcctctattc ctggctgcct gctgggcgtg 1620
gcactggagg gcgacgggag cccccacggg catgcctccc tgctgcagca tgtgctgttg 1680
ctggagcagg cccggcagca gagcaccctc attgctgtgc cactccacgg gcagtcccca 1740
ctagtgacgg gtgaacgtgt ggccaccagc atgcggacgg taggcaagct cccgcggcat 1800
cggcccctga gccgcactca gtcctcaccg ctgccgcaga gtccccaggc cctgcagcag 1860
ctggtcatgc aacaacagca ccagcagttc ctggagaagc agaagcagca gcagctacag 1920
ctgggcaaga tcctcaccaa gacaggggag ctgcccaggc agcccaccac ccaccctgag 1980
gagacagagg aggagctgac ggagcagcag gaggtcttgc tgggggaggg agccctgacc 2040
atgccccggg agggctccac agagagtgag agcacacagg aagacctgga ggaggaggac 2100
gaggaagacg atggggagga ggaggaggat tgcatccagg ttaaggacga ggagggcgag 2160
agtggtgctg aggaggggcc cgacttggag gagcctggtg ctggatacaa aaaactgttc 2220
tcagatgccc agccgctgca gcctttgcag gtgtaccagg cgcccctcag cctggccact 2280
gtgccccacc aggccctggg ccgtacccag tcctcccctg ctgcccctgg gggcatgaag 2340
agccccccag accagcccgt caagcacctc ttcaccacag gtgtggtcta cgacacgttc 2400
atgctaaagc accagtgcat gtgcgggaac acacacgtgc accctgagca tgctggccgg 2460
atccagagca tctggtcccg gctgcaggag acaggcctgc ttagcaagtg cgagcggatc 2520
cgaggtcgca aagccacgct agatgagatc cagacagtgc actctgaata ccacaccctg 2580
ctctatggga ccagtcccct caaccggcag aagctagaca gcaagaagtt gctcggcccc 2640
atcagccaga agatgtatgc tgtgctgcct tgtgggggca tcggggtgga cagtgacacc 2700
gtgtggaatg agatgcactc ctccagtgct gtgcgcatgg cagtgggctg cctgctggag 2760
ctggccttca aggtggctgc aggagagctc aagaatggat ttgccatcat ccggccccca 2820
ggacaccacg ccgaggaatc cacagccatg ggattctgct tcttcaactc tgtagccatc 2880
accgcaaaac tcctacagca gaagttgaac gtgggcaagg tcctcatcgt ggactgggac 2940
attcaccatg gcaatggcac ccagcaggcg ttctacaatg acccctctgt gctctacatc 3000
tctctgcatc gctatgacaa cgggaacttc tttccaggct ctggggctcc tgaagaggtt 3060
ggtggaggac caggcgtggg gtacaatgtg aacgtggcat ggacaggagg tgtggacccc 3120
cccattggag acgtggagta ccttacagcc ttcaggacag tggtgatgcc cattgcccac 3180
gagttctcac ctgatgtggt cctagtctcc gccgggtttg atgctgttga aggacatctg 3240
tctcctctgg gtggctactc tgtcaccgcc agatgttttg gccacttgac caggcagctg 3300
atgaccctgg cagggggccg ggtggtgctg gccctggagg gaggccatga cttgaccgcc 3360
atctgtgatg cctctgaggc ttgtgtctcg gctctgctca gtgtagagct gcagcccttg 3420
gatgaggcag tcttgcagca aaagcccaac atcaacgcag tggccacgct agagaaagtc 3480
atcgagatcc agagcaaaca ctggagctgt gtgcagaagt tcgccgctgg tctgggccgg 3540
tccctgcgag aggcccaagc aggtgagacc gaggaggccg agactgtgag cgccatggcc 3600
ttgctgtcgg tgggggccga gcaggcccag gctgcggcag cccgggaaca cagccccagg 3660
ccggcagagg agcccatgga gcaggagcct gccctgtgac gccccggccc ccatccctct 3720
gggcttcacc attgtgattt tgtttatttt ttctattaaa aacaaaaagt cacacattca 3780
acaaggtgtg ccgtgtgggt ctctcagcct tgcccctcct gctcctctac gctgcctcag 3840
gcccccagcc ctgtggcttc cacctcagct ctagaagcct gctccctctg cagggggtgg 3900
tggtgtcttc ccagccctgt cccatgtgtc cctcccccca ttttcctgca ttctgtctgt 3960
ccttttcctc cttggagcct gggccagctc aaggtgggca cgggggccca gacagtactc 4020
tccagttctg gggccccccg agtgaggagg gaacgggaag tcggtgcctt ggtttcagct 4080
gatttggggg gaaatgcctt aatttcactc tcctcccttc tccagcctca ggggaggatc 4140
tggaggatcc actactgtct ttaagatgca gagtggaggg gaggtgggca cccaccctgc 4200
gattctccac cctttcccct tctttcgtcc tcaccatctc tgcagacccc tctcctcctc 4260
cttcctcttg gtctcagcac tgatgggagg ctggtgccca agctgtggcc tgcagtctgt 4320
gaggagggct gtcttgcctc acactcctca cagcctactt ccccttcccc ggggctgaga 4380
gggtgaaagt gtgtggggaa ggagaggact ggtttcctgg gttctcaggg gccaggagga 4440
gtaacagaac caggtctgct ccccacctta ctcggatggc ctccctgccc ctctgctggc 4500
acagcctggg caaggggaga aggtggtccc tgcagagggg ctccaggctg gtgagagccc 4560
ccctgctgtc aggaccagat tttcccagcc atccagcatg ctgcggggag aaggggcaga 4620
ggctcacctc cctcctgggg ccttttgttt tggatcctgg ggatggtgag aatggaggtt 4680
ctagaagggg taaggccaga acccagggat ccaggagtcg gctctcagct ggagcttcca 4740
taccttctgg gctccctttg ctgaccacca gcccaaggga gctaagacca ggagggggct 4800
gggcgctgtc ccttctcttt cccaggagcc ctgccagggg ctgtgggcct acaaggcttc 4860
caggggatgc catccagcct gtaggaaacc aaagatggga agtggctcct agggggctga 4920
ctcttccttc ctcctcctcc ccagtaccac atatactttc tctccttcta tctccagggc 4980
cccaccaatc tgtttacata tttattatcc tatgggggcc tgagcaggat tgagggagcc 5040
aggggagggg caggagtccc agcaccatcg gttcatagtg tgcttgtgtg tttgttttag 5100
atcctcctgg gggatgggga tggggccagg ctcagtgtac taggcctctc tgtgctgagc 5160
cccaggctcc cggcccctta cccactctct ccctgtggct ggtctggttc tcatgtaaac 5220
ccactccttg ctttgtctcc ctggatatgg atttcagtta agtattttgt aacccgttac 5280
actgtgtgtc cttgtgtaaa taaacttgtt tctggcagtg cc 5322
<210> 16
<211> 4332
<212> DNA
<213> 小家鼠
<400> 16
ggtcacgtga cgagagtgac gtctccgaat gttgttgttg gtggcggcgg cgagcggagc 60
cggaggagcc gccgcaaaga tggaggagcc gtcgaggagg cgctgccgct gctgttgccg 120
ccgctgctgc cgccgccgcc cgcgaagccg gagctcgagc cgcagcgggg atgccgttct 180
gagtgcctga ctgcctcgcc ccgccccgaa ggatggcctt ggatgggcat tagaggcact 240
gcggccctgg gctcgggctc ctgtcccgtc cgtctgtctg ttatcgtctg tctctcttga 300
catcacagca gctccgcccc ctcccgtccc agcccccaac gtcagcttcc tgcaggccca 360
gagccggcat gaactctccc aacgagtcgg cttccttcca gagggattgg aggctcagga 420
ctggctggtg aggagaggca gtatcaaccc agagaggaag tagaagatga caaaaaaggg 480
ggaagagaga agatccaggc tggctgcttg gtgtccagtc cgttgtttgc ccccagcagt 540
ggccaaagct gaccccagat gcatgggtcc tctgcctgca cccttctcta gtccagccac 600
tggccaccca gactttggtc cacgctcctg gagcggagag caggcccttc agcctcatta 660
gcctccctgc gtctgctgcc tccggagcgc gcccaggccg gatgaggtgc ctccttgcct 720
cgtgggtccc agcggcagtg gcctgaggga gtccttgagc agccagctgg ccccgctgac 780
caccttttcc ctcaccggct tccgcctcgg gcggcccctc cctggcatgc tgctggtgcc 840
caaggcacag gggcttgtgg agatgctgca gaccatctat gagaccgagt cctgtttctc 900
agcagatggc atgtcaggcc gggaaccatc cttggaaatc ctgccacgga ctcctctgca 960
cagcatccct gtggcagtgg aggtgaagcc ggtgctgcca ggagccatgc ccagctccat 1020
ggggggtgga ggtggaggta gccccagccc cgtggagctt cggggggctc tggcgggccc 1080
catggaccct gcgctacggg agcagcaact gcagcaggag ctcctggtcc tcaagcagca 1140
gcagcagctc cagaagcagc tcctgttcgc cgagttccag aagcagcacg accacttgac 1200
gcggcagcac gaggtccagc tgcagaagca cctcaagcag cagcaggaga tgctggcggc 1260
taagaggcag caggagctgg agcagcagcg gcagcgggag cagcagcggc aggaggagct 1320
ggagaaacag cggctggagc agcagctgct catcctgcgc aacaaggaga agagcaaaga 1380
gagtgccatc gccagcaccg aggtaaagct gaggctccag gaattcctgt tgtccaagtc 1440
aaaggagccc acgccaggcg gcctcaacca ttccctccca cagcacccca aatgctgggg 1500
agcccaccac gcttctttgg accagagttc ccctccccag agcggccctc ctgggacgcc 1560
tccctcctac aaattgcctt tgcttgggcc ctatgacagc cgtgatgact ttcccctccg 1620
taaaacggcc tcggaaccca acttaaaagt acgttcgagg ctaaaacaga aggtagccga 1680
gaggagaagc agtcccctcc tgcgtcgaaa ggatggcact gttattagta cttttaagaa 1740
gagagcagtt gagatcaccg gcacggggcc tggggtgtcg tccgtgtgta acagtgcgcc 1800
cggctctggc cccagctctc ccaacagttc ccacagcacc atcgctgaga acggctttac 1860
tggctcagtc cccaacatcc ccactgagat gatcccccag caccgggccc tccctctgga 1920
cagttcccca aaccagttca gcctctatac gtctccttct ctgcccaaca tctccctagg 1980
gctgcaggcc actgtcactg tcaccaactc gcacctcacc gcctccccga agctgtcaac 2040
acagcaggag gctgagaggc aggcccttca gtccctgcgg cagggcggca cactgaccgg 2100
caagttcatg agcacatcct ccatccctgg ctgcctgttg ggagtggcac tggagggtga 2160
cacaagcccc cacgggcacg cttccctgct gcagcacgtt ttgctcctgg agcaggcccg 2220
gcaacagagc acgctcatag cagtgccgct ccatgggcag tccccactgg tgacgggtga 2280
acgtgtggcc accagcatga ggacggtggg taagctcccg aggcaccgac ctctgagccg 2340
cactcagtcc tccccgctgc cgcagagtcc ccaggccctg cagcagctgg tcatgcagca 2400
gcagcaccag cagttcctgg agaagcagaa gcagcagcag atgcagctgg gcaagatcct 2460
taccaaaact ggggagctgt caaggcagcc caccactcac ccggaggaga cagaagagga 2520
gctgacggag cagcaggagg ccttgctggg agagggggcc ctgaccattc cccgggaagg 2580
ctctacagaa agtgagagca cccaggaaga cctagaagag gaggaggagg aggaggagga 2640
ggaagaggag gactgcattc aggtcaagga tgaggatggc gagagtggtc ctgatgaagg 2700
ccctgactta gaagagtcca gtgctggtta caaaaagttg ttcgcagatg cccagcagtt 2760
acagcccctc caggtgtacc aggcacccct cagcctggcc actgtgcctc atcaggccct 2820
gggccgcacc cagtcctcac ctgctgctcc tgggagcatg aagagcccca cagaccaacc 2880
cactgtggtg aagcacctct tcaccacagg tgtggtctat gacacgttca tgctgaagca 2940
ccagtgtatg tgcggaaaca cacacgtgca cccagagcac gccggccgca tccagagcat 3000
ctggtcccgg ctgcaggaaa ctggtctgct cggcaagtgt gagcggatcc ggggtcgtaa 3060
agccacactg gatgaaatcc agaccgtgca ctctgagtac cacaccctgc tctatgggac 3120
cagccccctt aaccggcaga agctggacag caagaagctg cttggcccca tcagccagaa 3180
gatgtacgcc atgctgccct gtgggggcat tggggtggac agtgacacgg tgtggaatga 3240
gatgcactcc tcaagtgccg tgcgaatggc agtgggctgc ctggtggagc tggccttcaa 3300
ggtggctgca ggagagctca agaatggatt tgctatcatc cggcccccag gacaccatgc 3360
tgaggagtcc acagccatgg gattctgctt cttcaactcc gtagccatca cagctaaact 3420
cctgcagcag aagctgagcg tgggcaaggt cctcatcgtg gactgggata ttcaccatgg 3480
caacggcacc cagcaagcat tctacaacga tccctctgtg ctctacatct ccctgcatcg 3540
ctacgacaac gggaacttct ttccaggctc tggggctcct gaagaggttg gtggagggcc 3600
aggtgtgggg tacaacgtaa atgtggcgtg gacaggaggt gtggatcccc ccattggaga 3660
tgtggaatac ctgacagcct tcaggacagt ggtgatgccc attgcccagg agttctcacc 3720
tgacgtcgtc ctagtctccg ctgggtttga tgctgttgaa ggacatctgt ctccactggg 3780
tggctattct gtcaccgcca gatgttttgg ccacttgacc aggcagctca tgacactggc 3840
tgggggccgg gtggtgctgg ccctggaggg aggccatgac ttgaccgcca tctgtgatgc 3900
ctctgaggcc tgtgtctcgg ctctgctcag cgtggagctg cagcccttgg atgaagcagt 3960
cttgcagcaa aagcccagcg tcaatgcggt tgccacacta gagaaagtca tcgagatcca 4020
gagcaaacac tggagctgtg tacagaggtt tgccgctggt ctgggctgct cgctgcggga 4080
ggctcagaca ggtgagaaag aggaggccga gactgtgagc gccatggccc tgctttccgt 4140
gggggctgag caggcccagg ctgttgccac tcaagagcac agccccaggt aagccagcag 4200
aggagcccat ggagcaggag cctgccctgt gacaccctgg cccccatccc tctgggcttc 4260
atcattgtga ttttgtttat tttttctatt aaaaacaaaa agtcacacat tcaaaaaaaa 4320
aaaaaaaaaa aa 4332
<210> 17
<211> 1724
<212> DNA
<213> 智人
<400> 17
agctctgcga ggggccggag cgcggcggag ccatgcagta cccgcacccc gggccggcgg 60
cgggcgccgt gggggtgccg ctgtacgcgc ccacgccgct gctgcaaccc gcacacccga 120
cgccctttta catcgaggac atcctgggcc gcgggcccgc cgcgcccacg cccgccccca 180
cgctgccgtc ccccaactcc tccttcacca gcctcgtgtc cccctaccgg accccggtgt 240
acgagcccac gccgatccat ccagccttct cgcaccactc cgccgccgcg ctggccgctg 300
cctacggacc cggcggcttc gggggccctc tgtacccctt cccgcggacg gtgaacgact 360
acacgcacgc cctgctccgc cacgaccccc tgggcaaacc tctactctgg agccccttct 420
tgcagaggcc tctgcataaa aggaaaggcg gccaggtgag attctccaac gaccagacca 480
tcgagctgga gaagaaattc gagacgcaga aatatctctc tccgcccgag aggaagcgtc 540
tggccaagat gctgcagctc agcgagagac aggtcaaaac ctggtttcag aatcgacgcg 600
ctaaatggag gagactaaaa caggagaacc ctcaaagcaa taaaaaagaa gaactggaaa 660
gtttggacag ttcctgtgat cagaggcaag atttgcccag tgaacagaat aaaggtgctt 720
ctttggatag ctctcaatgt tcgccctccc ctgcctccca ggaagacctt gaatcagaga 780
tttcagagga ttctgatcag gaagtggaca ttgagggcga taaaagctat tttaatgctg 840
gatgatgacc actggcattg gcatgttcag aaaactggat ttaggaataa tgttttgcta 900
cagaaaatct tcatagaaga actggaaggc tatataagaa agggaatcaa ttctctggta 960
ttctggaaac ctaaaaatat ttggtgcact gctcaattaa caaacctaca tggagacctt 1020
aattttgact taacaaatag tttatgtact gctcttaggt tgttttgata aagtgacatt 1080
atagtgatta aattcttccc cctttaaaaa aacagttagt ggttttcact atttataaaa 1140
aattaatttt gaactttttg ttaaattttt aagttatagc tttaaaggtt ttaataggac 1200
cttcttgaac gacttttctg taatctgttt atctcccact taatggaaag gcaaaggggt 1260
accccaaatc cagaggtgcc tacatttcag gcagccttgg agtattttaa aaggaaaaca 1320
ttctttactt ttatatgaca ttcttatact gctgtctcaa atccaaaaac atttcagagc 1380
tcttgtctca gagatgtgtg ttctttttgt cagagatatg gttgatgaga atcttaaatg 1440
cttgttttgc actatcactt agtacctgtt tgaccaaggt gttaagggga tagtacctcc 1500
caattcaagc agagaaactg acctgactaa agttaatcgc agatgaacta gaagtcacag 1560
gttaattaaa tgtaagtaga ttgtagatac tgttttatat caaacaatgt ttataatgtg 1620
tatatagaat tgttcactgt aaaaaaaatg gccaaaatgt gttttttttt taataagtaa 1680
cttgactata aaataaagcc gtccgtggga cgactgacct cgtt 1724
<210> 18
<211> 1771
<212> DNA
<213> 小家鼠
<400> 18
agctctctgc gaggggctgc ggagcggcca tgcagttccc gcacccgggg cccgcggctg 60
cgcccgccgt gggagtcccg ctgtatgcgc ccacgccgct gctgcagccc gctcacccga 120
cgcccttcta catcgacgac atcttgggtc gcgggcccgc cgcccccacg cccactccca 180
cgctgccgtc ccccaactcc tccttcacca gcctcgtgtc ctcctaccgg accccggtgt 240
acgagcccac gccggtccac cccgccttct cgcaccaccc ggccgccgcg ctggccgccg 300
cctacggccc cagtggcttc ggaggccctc tgtacccgtt cccgcggacg gtgaacgact 360
acacgcacgc cctactccgc cacgaccccc tgggcaagcc cttgctctgg agccccttcc 420
tccagcgacc tctgcacaaa aggaaaggcg gtcaagtgag gttctccaac gaccagaccg 480
tcgagctgga gaagaagttc gagactcaga aatacctctc cccacccgag agaaagcgtc 540
tggccaagat gttacagctc agtgagagac aggtcaaaac ctggtttcag aatcgccgag 600
ctaaatggag aagactgaaa caggagaatc ctcaaagcaa caaaaaggat gcgttggaca 660
gtttggacac ttcctgtgag cagggtcaag acttgcccag tgaacagaat aaaggtgcct 720
ctttggatcg ttcgcagtgt tcaccctccc cagcctctca ggaagacccc gactcggaga 780
tctcagagga ttccgaccag gaggtggaca tcgaggggga taaaggctac tttaatgctg 840
gatgacagtc atcggccatg tttagagacc ggactttaga ataatgtttt gctacagacc 900
aactggaaaa ttcgggggga gagagagaga gagaaagaga gagagagaga gagagagaga 960
gagagataac aattcttgta gagttttgaa aatgtttggt gcactggcta attaacaaac 1020
atgcattgcg ttgagacctt aactttggtt taacatacgg tatctatacc agtttttaag 1080
ttgttttgat aaagtgacta aatgtgacct cattttttaa aaagtgaatt tatttctatt 1140
tatgagaggt aatttgaact tttgtctaaa gcttaaatta tgactttaaa ggttttaagt 1200
tttaggaggc tgatcttgac tgactttcct aagtctgtag ctattccctc gactttagag 1260
gtgcacttag gtgggggcaa catttgggga atccatggaa cactttgaaa gggtataccc 1320
aacttttaca tggcatctta cattgctgcc ttaactccaa agccatttca gagcacttgg 1380
ctcccggtgt ctgttcttac aagcaagata gttgataaga ttctaaaaat cttgttttgc 1440
tcagccagtg cctctgaccc tggtgttaag ggatgacgca gtccctacag gcagggaaac 1500
tgactcattt gagactgatc tcacacgaac tagaaatagc aggacaattc aatgtaagta 1560
gattgtagat agtgtgtttt atagaaactg tgtctataac atgtatatag cattacttct 1620
tgtaaaaact ctgccaaaat gatgtttgtt tgtttggttg gttttttgta atttaatgaa 1680
ttaactttca tatacattca tcatcagatg aacgaccctg tttgaattct cattctttgg 1740
ttaaaatacc taaacatgac acctaaagag c 1771
<210> 19
<211> 1670
<212> DNA
<213> 智人
<400> 19
ataaattgtg caagggtgct atagacgcac aaacgaccgc gagccacaaa tcaagcacac 60
atatcaaaaa acaaatgagc tcttattttg taaactcatt ttgcggtcgc tatccaaatg 120
gcccggacta ccagttgcat aattatggag atcatagttc cgtgagcgag caattcaggg 180
actcggcgag catgcactcc ggcaggtacg gctacggcta caatggcatg gatctcagcg 240
tcggccgctc gggctccggc cactttggct ccggagagcg cgcccgcagc tacgctgcca 300
gcgccagcgc ggcgcccgcc gagcccaggt acagccagcc ggccacgtcc acgcactctc 360
ctcagcccga tccgctgccc tgctccgccg tggccccctc gcccggcagc gacagccacc 420
acggcgggaa aaactcccta agcaactcca gcggcgcctc ggccgacgcc ggcagcaccc 480
acatcagcag cagagagggg gttggcacgg cgtccggagc cgaggaggac gcccctgcca 540
gcagcgagca ggcgagtgcg cagagcgagc cgagcccggc gccgcccgcc caaccccaga 600
tctacccctg gatgcgcaag ctgcacataa gtcatgacaa cataggcggc ccggaaggca 660
aaagggcccg gacggcctac acgcgctacc agaccctgga gctggagaag gagttccact 720
tcaaccgtta cctgacccgc agaaggagga ttgaaatagc acatgctctt tgcctctccg 780
agagacaaat taaaatctgg ttccaaaacc ggagaatgaa gtggaaaaaa gataataagc 840
tgaaaagcat gagcatggcc gcggcaggag gggccttccg tccctgagta tctgagcgtt 900
taaagtactg agcagtatta gcggatcccg cgtagtgtca gtactaaggt gactttctga 960
aactcccttg tgttccttct gtgaagaagc cctgttctcg ttgccctaat tcatctttta 1020
atcatgagcc tgtttattgc cattatagcg cctgtataag tagatctgct ttctgttcat 1080
ctctttgtcc tgaatggctt tgtcttgaaa aaaaatagat gttttaactt atttatatga 1140
agcaagctgt gttacttgaa gtaactataa caaaaaaaga aaagagaaaa aaaaacacac 1200
aaaaagtccc ccttcaatct cgtttagtgc caatgttgtg tgttgcactc aagttgttta 1260
actgtgcatg tgcgtggaag tgttcctgtc tcaatagctc caagctgtta aagatatttt 1320
tattcaaact acctatattc cttgtgtaat taatgctgtt gtagaggtga cttgatgaga 1380
cacaacttgt tcgacgtgta gtgactagtg actctgtgat gaaaactgtg actccaagcg 1440
gtgtgtccct gcgtgccttt ataggaccct ttgcacgaac tctggaagtg gctcttataa 1500
gcgcagcttc agtgatgtat gtttttgtga acaaagttac aaatattgtc caagtctggc 1560
tgttttaagc aaactgtgat cagctttttt tttttttttt ttttttttgt atttgttttt 1620
aaggaaaaaa tactgactgg aacaaaaaat aaactttcta ttgtaagttc 1670
<210> 20
<211> 1877
<212> DNA
<213> 小家鼠
<400> 20
ctccacccaa ctcccccatt agtgcacgag tttacctcta gaggtcatca ggcaggattt 60
acgactggac aacaaaagca cgtgattcga agtcgtaccc catatttggg tgcctacgta 120
ggagggaacc gagtacatgt cccagtcatt tccataattc atcataaatt gtgcaagggt 180
gctatagacg cacaaacgac cgcgagccac aaatcaagca cacatatcaa aaaacaaatg 240
agctcttatt ttgtaaactc attttgcggt cgctatccaa atggcccgga ctaccagttg 300
cataattatg gagatcatag ttccgtgagc gaacaattca gggactcggc gagcatgcac 360
tccggcaggt acggctacgg ctacaatggc atggatctca gcgtcggccg ttcgggttcc 420
ggccactttg gctccggcga gcgcgcccgc agctacgcgg ctggggccag tgcggcgccc 480
gccgagccca ggtacagcca gccggccacg tccacgcact cgccaccgcc cgacccgctg 540
ccctgctcag cggtggcccc ctcgcccggc agcgacagcc accacggcgg gaaaaactcc 600
ctgggcaact ccagcggcgc ctcggccaac gccggcagca cccacatcag cagcagagag 660
ggggttggca cggcgtccgc agccgaggag gacgcccctg ccagcagcga gcaggcgggc 720
gcccagagcg agccgagccc ggcgccgccc gctcagcccc agatctaccc ctggatgcgc 780
aagctgcaca ttagtcacga caatataggt ggcccagaag gcaaaagggc ccggacggcc 840
tacactcgct accagaccct ggagctggag aaagaattcc acttcaaccg ctacctgacc 900
cgccgaagaa ggatcgaaat agctcatgcc ctttgcctct ccgagagaca aattaaaatc 960
tggttccaaa acaggaggat gaagtggaaa aaagataata agctgaaaag catgagtatg 1020
gccgcggcag ggggggcttt ccgcccctga gcatctgagc ggccaaagta ctgagcagta 1080
gtagccgggc agctctctgt agtgtcagta ctaaggtgac tttctgaaac tccccttgtg 1140
ttccttctgt gaagaagccc tgttctcgtt gccctaattc atcttttaat catgagcctg 1200
tttattgcca ttatagcgcc tgtataagta gatctgcttc tgttcatctc tttgtcctga 1260
atggctttgt cttgaaaaaa aaatagatgt tttaacttat ttatatgaag caagctgtgt 1320
tacttgaagt aactaaaaca aaaaaaaaaa aaaaagaaaa gagaaaaaaa aactacacac 1380
acaaaaagcc cccccacctc gtttagtgcc aatgttgtgt gttgcacttg agttctttaa 1440
tgtgcatgta cgtggaagtg ttcctgtctc aatagctcca agctgttaaa gatattttta 1500
ttcaaactac ctatattcct tgtgtaatta atgctgttgt agaggtgact tgataagaca 1560
caaattaact tgttcaacgt gtagtggcta gtggctctgt gacgaaaact gtgactccaa 1620
gcggtgtgtc cctgcgtgcc tttgtaggac cctttgcacg aactctggaa gtggctctta 1680
taagcgcagc ttcagtgatg tatgtttttg tgaaaaagtt acaaatattg tccaagtctg 1740
gctgtttaag caaactgtga tcagcttttt tttttttttg tatttgtttt taaggaaaaa 1800
aaacactgac tggaaacaaa acaaaataaa ctttctattg taagttctct tggtctgatt 1860
tatgccaaat agcaagc 1877
<210> 21
<211> 950
<212> DNA
<213> 智人
<400> 21
gcgttgcagg tcactgtagc gggacttctt ttggttttct ttctctttgg ggcacctctg 60
gactcactcc ccagcatgaa ggcgctgagc ccggtgcgcg gctgctacga ggcggtgtgc 120
tgcctgtcgg aacgcagtct ggccatcgcc cggggccgag ggaagggccc ggcagctgag 180
gagccgctga gcttgctgga cgacatgaac cactgctact cccgcctgcg ggaactggta 240
cccggagtcc cgagaggcac tcagcttagc caggtggaaa tcctacagcg cgtcatcgac 300
tacattctcg acctgcaggt agtcctggcc gagccagccc ctggaccccc tgatggcccc 360
caccttccca tccagacagc cgagctcact ccggaacttg tcatctccaa cgacaaaagg 420
agcttttgcc actgactcgg ccgtgtcctg acacctccag aacgcaggtg ctggcgcccg 480
ttctgcctgg gaccccggga acctctcctg ccggaagccg gacggcaggg atgggcccca 540
acttcgccct gcccacttga cttcaccaaa tcccttcctg gagactaaac ctggtgctca 600
ggagcgaagg actgtgaact tgtggcctga agagccagag ctagctctgg ccaccagctg 660
ggcgacgtca ccctgctccc accccacccc caagttctaa ggtctcttca gagcgtggag 720
gtgtggaagg agtggctgct ctccaaacta tgccaaggcg gcggcagagc tggtcttctg 780
gtctccttgg agaaaggttc tgttgccctg atttatgaac tctataatag agtatatagg 840
ttttgtacct tttttacagg aaggtgactt tctgtaacaa tgcgatgtat attaaacttt 900
ttataaaagt taacattttg cataataaac gatttttaaa cacttgtgta 950
<210> 22
<211> 964
<212> DNA
<213> 小家鼠
<400> 22
gcactgtttg ctgctttagg tgtctctttt cctccctctc tatctctact ctccaacatg 60
aaggcgctga gcccggtgcg cggctgctac gaggcggtgt gctgcctgtc ggaacgtagc 120
ctggccattg cgcgaggccg cggtaagagc ccgtcgaccg aggagcctct tagcctcttg 180
gacgacatga accactgcta ctcgcgcctg cgggaactgg tgccgggagt cccgcgaggc 240
actcagctta gccaggtgga aatcctgcag cgtgtcatag actacatcct cgaccttcag 300
gtggtcctgg cagagccggc gcctggaccc ccggacggtc cgcatctccc gatccagaca 360
gctgagctca ctccggaact tgtgatctcc aaggacaaga ggagcttttg ccactgaccc 420
ggtcgtcctg gcacctcccg aacgcaggtg ctggcgcccg ttccgcttgg gaccctggga 480
ctctgggacc ctctctccag ccggaagcct gagggcatgg atgagcttcg atcttaaccc 540
agccctcttc acttaccctg aactcaacgc ctcgaggctg gacctggagc ccgagagaag 600
gactgaactt gggtggcctg aagagctagc acacgctggt cagcagctgg gcaacgtcac 660
tctgtcccca ccctgactca agtctaaaag actggctttt ccgagaatgg ggtgtcgaga 720
gggtgtgggg ggatgcgagt ggctgccctg cgcactctgc caaggcagca taagagctgt 780
tcttctggtt tccttggaga aaagctctgc tgccctgatt atgaactcta taatagagta 840
tatagctttt gtaccttttt tacaggaagg tgactttctg taatcatgtg atgtatatta 900
aactttttat aaaagttaac attttgcata ataaaccatt tttgaacact ttgaaaaaaa 960
aaaa 964
<210> 23
<211> 6255
<212> DNA
<213> 智人
<400> 23
actctaacaa gtgactgcgc ggcccgcgcc cggggcggtg actgcggcaa gccccctggg 60
tccccgcgcg gcgcatccca gcctgggcgg gacgctcggc cgcggcgagg cgggcaagcc 120
tggcagggca gagggagccc cggctccgag gttgctcttc gcacccgagg atcagtcttg 180
gccccaaagc gcgacgcaca aatccacata acctgaggac catggatgct gatgagggtc 240
aagacatgtc ccaagtttca gggaaggaaa gcccccctgt aagcgatact ccagatgagg 300
gcgatgagcc catgccgatc cccgaggacc tctccaccac ctcgggagga cagcaaagct 360
ccaagagtga cagagtcgtg gccagtaatg ttaaagtaga gactcagagt gatgaagaga 420
atgggcgtgc ctgtgaaatg aatggggaag aatgtgcgga ggatttacga atgcttgatg 480
cctcgggaga gaaaatgaat ggctcccaca gggaccaagg cagctcggct ttgtcgggag 540
ttggaggcat tcgacttcct aacggaaaac taaagtgtga tatctgtggg atcatttgca 600
tcgggcccaa tgtgctcatg gttcacaaaa gaagccacac tggagaacgg cccttccagt 660
gcaatcagtg cggggcctca ttcacccaga agggcaacct gctccggcac atcaagctgc 720
attccgggga gaagcccttc aaatgccacc tctgcaacta cgcctgccgc cggagggacg 780
ccctcactgg ccacctgagg acgcactccg ttggtaaacc tcacaaatgt ggatattgtg 840
gccgaagcta taaacagcga agctctttag aggaacataa agagcgctgc cacaactact 900
tggaaagcat gggccttccg ggcacactgt acccagtcat taaagaagaa actaatcaca 960
gtgaaatggc agaagacctg tgcaagatag gatcagagag atctctcgtg ctggacagac 1020
tagcaagtaa cgtcgccaaa cgtaagagct ctatgcctca gaaatttctt ggggacaagg 1080
gcctgtccga cacgccctac gacagcagcg ccagctacga gaaggagaac gaaatgatga 1140
agtcccacgt gatggaccaa gccatcaaca acgccatcaa ctacctgggg gccgagtccc 1200
tgcgcccgct ggtgcagacg cccccgggcg gttccgaggt ggtcccggtc atcagcccga 1260
tgtaccagct gcacaagccg ctcgcggagg gcaccccgcg ctccaaccac tcggcccagg 1320
acagcgccgt ggagaacctg ctgctgctct ccaaggccaa gttggtgccc tcggagcgcg 1380
aggcgtcccc gagcaacagc tgccaagact ccacggacac cgagagcaac aacgaggagc 1440
agcgcagcgg tctcatctac ctgaccaacc acatcgcccc gcacgcgcgc aacgggctgt 1500
cgctcaagga ggagcaccgc gcctacgacc tgctgcgcgc cgcctccgag aactcgcagg 1560
acgcgctccg cgtggtcagc accagcgggg agcagatgaa ggtgtacaag tgcgaacact 1620
gccgggtgct cttcctggat cacgtcatgt acaccatcca catgggctgc cacggcttcc 1680
gtgatccttt tgagtgcaac atgtgcggct accacagcca ggaccggtac gagttctcgt 1740
cgcacataac gcgaggggag caccgcttcc acatgagcta aagccctccc gcgcccccac 1800
cccagacccc gagccacccc aggaaaagca caaggactgc cgccttctcg ctcccgccag 1860
cagcatagac tggactggac cagacaatgt tgtgtttgga tttgtaactg ttttttgttt 1920
tttgtttgag ttggttgatt ggggtttgat ttgcttttga aaagattttt atttttagag 1980
gcagggctgc attgggagca tccagaactg ctaccttcct agatgtttcc ccagaccgct 2040
ggctgagatt ccctcacctg tcgcttccta gaatcccctt ctccaaacga ttagtctaaa 2100
ttttcagaga gaaatagata aaacacgcca cagcctggga aggagcgtgc tctaccctgt 2160
gctaagcacg gggttcgcgc accaggtgtc tttttccagt ccccagaagc agagagcaca 2220
gcccctgctg tgtgggtctg caggtgagca gacaggacag gtgtgccgcc acccaagtgc 2280
caagacacag cagggccaac aacctgtgcc caggccagct tcgagctaca tgcatctagg 2340
gcggagaggc tgcacttgtg agagaaaata ctatttcaag tcatattctg cgtaggaaaa 2400
tgaattggtt ggggaaagtc gtgtctgtca gactgccctg ggtggaggga gacgccgggc 2460
tagagccttt gggatcgtcc tggattcact ggctttgcgg aggctgctca gatggcctga 2520
gcctcccgag gcttgctgcc ccgtaggagg agactgtctt cccgtgggca tatctgggga 2580
gccctgttcc ccgctttttc actcccatac ctttaatggc ccccaaaatc tgtcactaca 2640
atttaaacac cagtcccgaa atttggatct tctttctttt tgaatctctc aaacggcaac 2700
attcctcaga aaccaaagct ttatttcaaa tctcttcctt ccctggctgg ttccatctag 2760
taccagaggc ctcttttcct gaagaaatcc aatcctagcc ctcattttaa ttatgtacat 2820
ctgtttgtag ccacaagcct gaatttctca gtgttggtaa gtttctttac ctaccctcac 2880
tatatattat tctcgtttta aaacccataa aggagtgatt tagaacagtc attaattttc 2940
aactcaatga aatatgtgaa gcccagcatc tctgttgcta acacacagag ctcacctgtt 3000
tgaaaccaag ctttcaaaca tgttgaagct ctttactgta aaggcaagcc agcatgtgtg 3060
tccacacata cataggatgg ctggctctgc acctgtagga tattggaatg cacagggcaa 3120
ttgagggact gagccagacc ttcggagagt aatgccacca gatcccctag gaaagaggag 3180
gcaaatggca ctgcaggtga gaaccccgcc catccgtgct atgacatgga ggcactgaag 3240
cccgaggaag gtgtgtggag attctaatcc caacaagcaa gggtctcctt caagattaat 3300
gctatcaatc attaaggtca ttactctcaa ccacctaggc aatgaagaat ataccatttc 3360
aaatatttac agtacttgtc ttcaccaaca ctgtcccaag gtgaaatgaa gcaacagaga 3420
ggaaattgta cataagtacc tcagcattta atccaaacag gggttcttag tctcagcact 3480
atgacatttt gggctgacta cttatttgtt aggcgggagc tctcctgtgc attgtaggat 3540
aattagcagt atccctggtg gctacccaat agacgccagt agcaccccga attgacaacc 3600
caaactctcc agacatcacc aactgtcccc tgcgaggaga aatcactcct gggggagaac 3660
cactgaccca aatgaattct aaaccaatca aatgtctggg aagccctcca agaaaaaaaa 3720
tagaaaagca cttgaagaat attcccaata ttcccggtca gcagtatcaa ggctgacttg 3780
tgttcatgtg gagtcattat aaattctata aatcaattat tccccttcgg tcttaaaaat 3840
atatttcctc ataaacattt gagttttgtt gaaaagatgg agtttacaaa gataccattc 3900
ttgagtcatg gatttctctg ctcacagaag ggtgtggcat ttggaaacgg gaataaacaa 3960
aattgctgca ccaatgcact gagtgaagga agagagacag aggatcaagg gctttagaca 4020
gcactccttc aatatgcaat cacagagaaa gatgcgcctt atccaagtta atatctctaa 4080
ggtgagagcc ttcttagagt cagtttgttg caaatttcac ctactctgtt cttttccatc 4140
catccccctg agtcagttgg ttgaagggag ttattttttc aagtggaatt caaacaaagc 4200
tcaaaccaga actgtaaata gtgattgcag gaattctttt ctaaactgct ttgccctttc 4260
ctctcactgc cttttatagc caatataaat gtctctttgc acaccttttg ttgtggtttt 4320
atattgtaac accatttttc tttgaaacta ttgtatttaa agtaaggttt catattatgt 4380
cagcaagtaa ttaacttatg tttaaaaggt ggccatatca tgtaccaaaa gttgctgaag 4440
tttctcttct agctggtaaa gtaggagttt gcatgacttc acactttttt tgcgtagttt 4500
cttctgttgt atgatggcgt gagtgtgtgt cttgggtacc gctgtgtact actgtgtgcc 4560
tagattccat gcactctcgt tgtgtttgaa gtaaatattg gagaccggag ggtaacaggt 4620
tggcctgttg attacagcta gtaatcgctg tgtcttgttc cgccccctcc ctgacacccc 4680
agcttcccag gatgtggaaa gcctggatct cagctccttg ccccatatcc cttctgtaat 4740
ttgtacctaa agagtgtgat tatcctaatt caagagtcac taaaactcat cacattatca 4800
ttgcatatca gcaaagggta aagtcctagc accaattgct tcacatacca gcatgttcca 4860
tttccaattt agaattagcc acataataaa atcttagaat cttccttgag aaagagctgc 4920
ctgagatgta gttttgttat atggttcccc accgaccatt tttgtgcttt tttcttgttt 4980
tgttttgttt tgactgcact gtgagttttg tagtgtcctc ttcttgccaa aacaaacgcg 5040
agatgaactg gacttatgta gacaaatcgt gatgccagtg tatccttcct ttcttcagtt 5100
ccagcaataa tgaatggtca acttttttaa aatctagatc tctctcattc atttcaatgt 5160
atttttactt taagatgaac caaaattatt agacttattt aagatgtaca ggcatcagaa 5220
aaaagaagca cataatgctt ttggtgcgat ggcactcact gtgaacatgt gtaaccacat 5280
attaatatgc aatattgttt ccaatacttt ctaatacagt tttttataat gttgtgtgtg 5340
gtgattgttc aggtcgaatc tgttgtatcc agtacagctt taggtcttca gctgcccttc 5400
tggcgagtac atgcacagga ttgtaaatga gaaatgcagt catatttcca gtctgcctct 5460
atgatgatgt taaattattg ctgtttagct gtgaacaagg gatgtaccac tggaggaata 5520
gagtatcctt ttgtacacat tttgaaatgc ttcttctgta gtgatagaac aaataaatgc 5580
aacgaatact ctgtctgccc tatcccgtga agtccacact ggcgtaagag aaggcccagc 5640
agagcaggaa tctgcctaga ctttctccca atgagatccc aatatgagag ggagaagaga 5700
tgggcctcag gacagctgca ataccacttg ggaacacatg tggtgtcttg atgtggccag 5760
cgcagcagtt cagcacaacg tacctcccat ctacaacagt gctggacgtg ggaattctaa 5820
gtcccagtct tgagggtggg tggagatgga gggcaacaag agatacattt ccagttctcc 5880
actgcagcat gcttcagtca ttctgtgagt ggccgggccc agggccctca caatttcact 5940
accttgtctt ttacatagtc ataagaatta tcctcaacat agccttttga cgctgtaaat 6000
cttgagtatt catttaccct tttctgatct cctggaaaca gctgcctgcc tgcattgcac 6060
ttctcttccc gaggagtggg gtaaatttaa aagtcaagtt atagtttgga tgttagtata 6120
gaattttgaa attgggaatt aaaaatcagg actggggact gggagaccaa aaatttctga 6180
tcccatttct gatggatgtg tcacaccttt tctgtcaaaa taaaatgtct tggaggttat 6240
gactccttgg tgaaa 6255
<210> 24
<211> 5451
<212> DNA
<213> 小家鼠
<400> 24
gtcagggtcc cgaagccgcg tgccgtgcgc gcaggccggg tgggctgtgg gacaagccga 60
gcgggaggcg agtcgcaagc gccaacccaa agtttgcacg gtgcggggcg aggggcgcgc 120
gctccgggct gccgcaggtg gcggcgcggt gagcccgggc caggtgcccc ggcagcgggg 180
cggcgctgtc gtgcgggaca gccgggctgc caggggctcg gagccgggtc ggagcccgcg 240
gggggcgggg agtgtggcga gaaatgggga acaatgcgag tgagcaactt gaggaagtca 300
ttgtgaaaga aagctgggaa ttgctccgca gccaacttag cagggcactc taacaagtgc 360
ctgcgcggcc gcgcccgggc cggggacagg ggcagcccgg cgcagtacag cccatcccgg 420
gacgctcggc cgcggctgcc ggagacccgg taggtcccgc ggggtgcagg agcccccaga 480
tccccggctg ctcttcgcgc cccaggatca ttcttggccc ccaaagcgcg gcgcacaaat 540
ccacataacc tgaagacaat ggatgtcgat gagggtcaag acatgtccca agtttcagga 600
aaggagagcc ccccagtcag tgacactcca gatgaagggg atgagcccat gcctgtccct 660
gaggacctgt ccactacctc tggagcacag cagaactcca agagtgatcg aggcatggcc 720
agtaatgtta aagtagagac tcagagtgat gaagagaatg ggcgtgcctg tgaaatgaat 780
ggggaagaat gtgcagagga tttacgaatg cttgatgcct cgggagagaa aatgaatggc 840
tcccacaggg accaaggcag ctcggctttg tcaggagttg gaggcattcg acttcctaac 900
ggaaaactaa agtgtgatat ctgtgggatc gtttgcatcg ggcccaatgt gctcatggtt 960
cacaaaagaa gtcatactgg tgaacggcct ttccagtgca accagtgtgg ggcctccttt 1020
acccagaaag gcaacctcct gcggcacatc aagctgcact cgggtgagaa gcccttcaaa 1080
tgccatcttt gcaactatgc ctgccgccgg agggacgccc tcaccggcca cctgaggacg 1140
cactccgttg gtaagcctca caaatgtgga tattgtggcc ggagctataa acagcgaagc 1200
tctttagagg agcataaaga gcgatgccac aactacttgg aaagcatggg ccttccgggc 1260
atgtacccag tcattaagga agaaactaac cacaacgaga tggcagaaga cctgtgcaag 1320
ataggagcag agaggtccct tgtcctggac aggctggcaa gcaatgtcgc caaacgtaag 1380
agctctatgc ctcagaaatt tcttggagac aagtgcctgt cagacatgcc ctatgacagt 1440
gccaactatg agaaggagga tatgatgaca tcccacgtga tggaccaggc catcaacaat 1500
gccatcaact acctgggggc tgagtccctg cgcccattgg tgcagacacc ccccggtagc 1560
tccgaggtgg tgccagtcat cagctccatg taccagctgc acaagccccc ctcagatggc 1620
cccccacggt ccaaccattc agcacaggac gccgtggata acttgctgct gctgtccaag 1680
gccaagtctg tgtcatcgga gcgagaggcc tccccgagca acagctgcca agactccaca 1740
gatacagaga gcaacgcgga ggaacagcgc agcggcctta tctacctaac caaccacatc 1800
aacccgcatg cacgcaatgg gctggctctc aaggaggagc agcgcgccta cgaggtgctg 1860
agggcggcct cagagaactc gcaggatgcc ttccgtgtgg tcagcacgag tggcgagcag 1920
ctgaaggtgt acaagtgcga acactgccgc gtgctcttcc tggatcacgt catgtatacc 1980
attcacatgg gctgccatgg ctttcgggat ccctttgagt gtaacatgtg tggttatcac 2040
agccaggaca ggtacgagtt ctcatcccat atcacgcggg gggagcatcg ttaccacctg 2100
agctaaaccc agccaggccc cactgaagca caaagatagc tggttatgcc tccttcccgg 2160
cagctggacc cacagcggac aatgttggga gtggatttgc aggcagcatt tgttctttta 2220
tgttggttgt ttggcgtttg atttgcgttg gaagataagt ttttaatgtt agtgacagga 2280
ttgcattgca tcaggaacat tcacaacatc catccttcta gccagttttg ttcactggta 2340
gctgaggttt cccggatatg tggcttccta acactctccc cacccacccc accccccaaa 2400
acagagcctg aatcttcatg aagtgaataa aacaattatc caagaaggag taaggtggat 2460
cttgccctaa gcagagttta tgccacaaag attctccaaa tcccccaaga cagcacagcc 2520
actggggttg agccatctca gggagctctg caggtgagcc agaggaccag atataaggca 2580
gctggggagg agcagggaca tcagcctgtg cagagaccaa ggccaaaggt tgaactttga 2640
aagactatta agtcatatat tgtatggcaa tatggtgtct ggacaagttg tgcaatgtgc 2700
tgaagggaag ggattggaga gccttgaaga ctcttcttca tttgcctgat caacccgacc 2760
tccagagggt ttgttgccca gtaagacgag ctcagtgctc ttgtgatcat ttttctctta 2820
tcgtttccat gccgttgatg gccctgaagc tcatcactgc attttagaac ccaatcctga 2880
aattgggacc ttttttttaa acttctgata ctgtaaaact tcttggaagc caaagctttc 2940
ttccaagccc catcctcagt tatcctggtt cctgttcttc cccgagctga tagtaccagg 3000
acctgttatt ccacaaaagc acaggcatcc gtcacttcaa ttcaatccct gttcagatta 3060
tagatatgga ctttgctatc ttgataaatg tcttctctat gttattttgt ctgaaaaacc 3120
tataaaacca ttattaagaa tgaccatttt tagatggaag aaatgagccc agcatctcag 3180
tggctaaaac acaaaatatc catgctttta aacaaaattg ttaaatattc cgaagctctc 3240
tagtataaac accaagtagc atgtgttttc acataaagaa gacaggggcc atgcaacctt 3300
tatcaagtgg aggtattaga atgttgtaat gtttggagac acagtgtgac cagtacaggt 3360
tcccagagag gaatgcccac catatcacag aaaggtagag gtgggatctg gtatagccag 3420
accaagacag ggatgtcacg ctgaagccaa gtcagttagc tgaagattct caacaggaag 3480
gcctctctta agagtcagta atagggttgt taccatccac cacctcaaca aaacaaaaag 3540
cttataattg taaatgttta cagcactgtc ttcgcagaaa ctttctgagg tgattccaaa 3600
gaactagagg ggagatggtc tataacagct cttgaagtaa acgaggttct tagtctcagc 3660
tctcctgaca tatagggctt gatcattact ggtagggatt gttctgtgaa ttgcttacta 3720
ctacccctgg tctctcccca gtagatgcca ggaacattct agctgatacc taactgtctt 3780
cccaggtgtt cgagggagca aaccactgat ctaaactcta aacgctgaag tacgcaggtt 3840
ttctaaaaat gacaagccct tgaaaccttt cccagtaggc agcctcgagc tggacttgtg 3900
tctttggaat gctgatgaat tctatagatc agcattgcaa atacacttca aatacgtctg 3960
agttcaagtg cagggactga gttcaccaag gtgtgaaatg tgctcaaaaa gttcaaaagt 4020
gtgtgtttct ttgtttctaa aacattgtgg catctttttc atttgtttct aaaacttttt 4080
ttttagaaac aaatgaagca cttggaaagt gaaagtaaaa ttacaaatat aaggatttac 4140
actgaagaga gaaaaatttt aggaactata gctgtgaaaa gattttgttc aaaaggcagg 4200
ctagccttac ccaaattcat atatggcagg tgtcaacctc ccaagcttac agttagcagg 4260
cagcttttgc tcactcatcc ttagccatga gagccattaa gtgtggtcca agaaagatgg 4320
ctccaaaccc tacccccgac ccaccagtgg tattcagaga ttaaagcaga attgtaaata 4380
gtggcttcag gagctctttt ttagaatgct ttgccccttc ctctcactgc cttttttagc 4440
caatataaat gtcaatttgc acaccttttg ttgtggtttt atattgtaac agcatttttt 4500
tgaaactatt gtatttaaga taaggtttca tattatgtcc acaagtaatt aaattatgtt 4560
tgaaggtggc tatatgctgt atcagaagtt gatgatgttt ttctttagct ggtaaaggag 4620
ggttttgcat gacctcactg tttgttctgt ggtttgttct gttgtatgat gtgtgtcttg 4680
agttttgctg tgtgatgaag tgcgctgaga ttccagtgcc ctcaagttgt gttttaagta 4740
gctatcagag gcaagagggt tcctaagagc aggttgacct gttggcgaca gatggcaatc 4800
accatttctc attccttctt ctccctgtta ccccagcttc ctgtcccagg tcccttctgt 4860
gattcttacc ttagtgtgca tgtgtgtctg tcctggtgag agtcaggagc atcgatatgt 4920
tatcattgca ttatcaccaa gggcacgcac agcctagcac ctgttgcttc agataccgtc 4980
acactctgtt tccaatttag atacaaccac ataataaaat gttagagtct tcaatgggaa 5040
gcagaggtgc ttgttataaa gatgggggct tatgcttgtg tcacattttg tgttcttttc 5100
ttcttttgtt tggttttaac ttaattgtga cccttgtaac atcatcttgc caaaaaaaaa 5160
aaaaaagttg aactggattt atgtagacat gtcaagacgt actatctatt tctttgtcag 5220
ttatagcaat aagagtggat aaactctaaa atccagatct cccacaatga acatccgtgt 5280
tctttctatg atttttcttt ctttatggtg agccacaatt aaacttgaga tgtacagcca 5340
cccaaaccca ggaagctcat gtgcatctgg tgctatggca ctcactgtga ataagtgtga 5400
ccagatatta atatgcaata ttgtttccaa tcctttctaa tacatttttt c 5451
<210> 25
<211> 9515
<212> DNA
<213> 智人
<400> 25
atttcttggt tttgtttatc agccgatctg tttgctggat ttgggcttgg aatgacccac 60
ctgtaaagtg cttttccttc ctcctcccct tgaactctgc agggggcttg gcttggaggg 120
ggcaagggag ggaaagagag aagggggaaa cacaaaaaac ttctttcttt ctccctccgt 180
ttatcttcag cccgacattg tcacctcctc tttgaggggt tagaagaagc tgagatctcc 240
cgacagagct ggaaatgcat tgcactttga ctatggaaac agaggctatt gatggctata 300
taacgtgtga caatgagctt tcacccgaaa gggagcactc caatatggca attgacctca 360
cctcaagcac acccaatgga cagcatgcct caccaagtca catgacaagc acaaattcag 420
taaagctaga aatgcagagt gatgaagagt gtgacaggaa acccctgagc cgtgaagatg 480
agatcagggg ccatgatgag ggtagcagcc tagaagaacc cctaattgag agcagcgagg 540
tggctgacaa caggaaagtc caggagcttc aaggcgaggg aggaatccgg cttccgaatg 600
gtaaactgaa atgtgacgtc tgtggcatgg tttgcattgg gcccaatgtg cttatggtac 660
ataaaaggag tcacactggt gaacgcccct tccactgtaa ccagtgtgga gcttctttta 720
ctcagaaggg caaccttctg agacacataa agttacactc tggagagaag ccgttcaaat 780
gtcctttctg tagctacgcc tgtagaagaa gggacgccct cacaggacac ctcaggaccc 840
attctgtggg taaacctcac aagtgcaact actgtggacg aagctacaag cagcgcagtt 900
cactggagga gcacaaggaa cgctgccaca actatctcca gaatgtcagc atggaggctg 960
ctgggcaggt catgagtcac catgtacctc ctatggaaga ttgtaaggaa caagagccta 1020
ttatggacaa caatatttct ctggtgcctt ttgagagacc tgctgtcata gagaagctca 1080
cggggaatat gggaaaacgt aaaagctcca ctccacaaaa gtttgtgggg gaaaagctca 1140
tgcgattcag ctacccagat attcactttg atatgaactt aacatatgag aaggaggctg 1200
agctgatgca gtctcatatg atggaccaag ccatcaacaa tgcaatcacc taccttggag 1260
ctgaggccct tcaccctctg atgcagcacc cgccaagcac aatcgctgaa gtggccccag 1320
ttataagctc agcttattct caggtctatc atccaaatag gatagaaaga cccattagca 1380
gggaaactgc tgatagtcat gaaaacaaca tggatggccc catctctctc atcagaccaa 1440
agagtcgacc ccaggaaaga gaggcctctc ccagcaatag ctgcctggat tccactgact 1500
cagaaagcag ccatgatgac caccagtcct accaaggaca ccctgcctta aatcccaaga 1560
ggaaacaaag cccagcttac atgaaggagg atgtcaaagc tttggatact accaaggctc 1620
ctaagggctc tctgaaggac atctacaagg tcttcaatgg agaaggagaa cagattaggg 1680
ccttcaagtg tgagcactgc cgagtccttt tcctagacca tgtcatgtac accattcaca 1740
tgggttgcca tggctaccgg gacccactgg aatgcaacat ctgtggctac agaagccagg 1800
accgttatga gttttcatca cacattgttc gaggggagca cacattccac taggcctttt 1860
cattccaaag gggaccccta tgaagtaaag aactgcacat gaagaaatac tgcacttaca 1920
atcccacctt tcctcaaatg ttgacatacc ttttattttt tttaatatta ttactgttga 1980
taattcttat tttgtggagg cagtgtcatt tgctctgcct aattacgata aggaagaaac 2040
agaagagaga aggggcggga atattgtttc tttatcacct ggcttgttta ttttgtggga 2100
atttaagagc agtccatttc taccaaggca tatcatgctt tgaaaaatca cttgattcat 2160
aaagattcac ctaagagatt ctgatttgcc actgatattc agaattatga tggaagacag 2220
gaaagttcag agttttctgg gtaggacttt ggtggtttaa aaatggtata agtaacttta 2280
ttcttgaaag aagaatgtgt ttcaaactgt aaaccaattt tttgttcttc agagatcatg 2340
gaacacaaac acattgttat tttcagtgat aactcctaag aggagctgag ttgttgtggg 2400
ttctatgttt acttccccta tggaatttat aattcagtat gttttacact gtaccatata 2460
gcaaaacttt taaactacag gtagttaagg gccacctaca atacatctga ggtcctgtga 2520
tcttattttt ctaaacgtaa gcactgtttt tccatagttt tgatgactgg cattttatag 2580
acaccctggc agccttactt ttaacacctt taaggaatag tatttttatg tagttttcag 2640
aataacatat ggtctaagag tggataaaag gcagtcaata atttctggga gggacttcta 2700
ctttcataaa tttgtttgag aggttttctt ttaaagttgt aatgtgatgg cagcatagta 2760
tatgtatttg tttctaaaag tatgcttacg attgtcactt tatcagcatt taatcagtgt 2820
taaccagtca gcagaaaaat ataattatgc taacagtagg gggagaaaac ccacttagaa 2880
atcccttttc tggtatttct cttttcacta gtttttttca agatgtgacc tcccggtgtt 2940
ctgtccatag ttcattcatc ctttactctt cgagtagaag gtcttaaaag tcttcctgtc 3000
ggctgtttct ttcaaaatct cctcagagca attgctaatt tggcctgaat ctggtaactt 3060
gaaccctgta aggttacaga actagggcta tttattttag catttcttca gtagtattta 3120
ctactcttgt tgcaaagaaa agggaatggg acttctttgt aacctgtacc ttggacaaca 3180
gataaaagaa acaaaaaaat aagaaagttt acttttaccc ttcttggagt ctagaatgtg 3240
acagaacccc caaaggaaag tcctgcacat ttttctgttt ccaaaacatt taattgtgta 3300
agtccttgtc agaaatgaat ctcaatccct tagtatagaa ttccccttac atggtatagg 3360
ttgccatatt tcatgtgcag attttaattt catttatgtg ggcgctctgt tttttctttg 3420
cagtccagcc acattagagg ggaggaaccg agtgatattg attcaagtca ttttaggggg 3480
acatacttgg aaggcagaac ttgctgcttc tgtttgggga ggacagacct gactgtgact 3540
ggattatctg ataaccattt gtgaatactg aaattctgtt aggcagtaac tgataactgc 3600
tctaaaggat cattaaatag gatgctgaaa ttatgtatct taatacagtg tggtatgaga 3660
attaccaagt caagagaatt gtggacataa gcaagtttgg ccccaatact gctcttaact 3720
cattttccag cttactattt gctatttaaa tggtaggcac cagctaagca cttctaagca 3780
ctaacacagc tagaactagg caaaaatggt tagaactcag ctctcttcta ctagtccctg 3840
tcataattat ttttgggaaa atgtccaaac tgcccccttt aaatctaagg gaatgcacca 3900
aaacagagat atatagaatg tcaaccattt catttttttt tttctgcatg ccttggtaca 3960
tagtgaacat acaacctatt taaagataaa gcatgttttt gagactcgct cacccccccc 4020
cacccaacca ctcccaaata ataattggga tgccattttt tttccttttg gatgaggtaa 4080
ataattttaa ggttcacaat tttgtctttt actgcaattt aaggaaacat ttggatgtca 4140
gtcaatatgt tcataatttt ggctgtgtgc gaatttctgc tggcattatc tatgaatttt 4200
cttcctactt attttttttt cagtatatga acaatcatgt atctacctgc cccaggatga 4260
aactaaattt aggtggaccc taaaccttat gaagacagtg ctgaggcact ttccttttct 4320
gatttcatct ttttgggaat ctgttttatt gaaggtagtt agtagttgag agtgcatttg 4380
ctacaagcat atacttgtat cttcctagct tcatgaggaa cagaaagagg tggatatggc 4440
tcagggtgtg gcagggacaa ttgaggacaa agtcaattca aatttgtggg tcagaaagaa 4500
tttttgtgga cgtagtgttt ttggagaaac tctggatggt tatatgtgca tgccttttct 4560
tcaaaaggaa atacgcaagg ttgtagcatc taaaaataaa cataagagtc agacaccaaa 4620
taaatcaagt tttacataac agttgtatgc ccagtttgtt taggtgagat ttcacattac 4680
agaaagtatt tgaggagcat gaaaatgggt tatcttctgt attttccagt ttggcaaaag 4740
ttcagaattt catcacattg ctttgcccta attttgccca gaattttatc ttagcctctc 4800
tctgacagtg atgaatcatg ctcaaaagcc attctaattg gaccttttta agacagggaa 4860
agggatcagt aggcggattg gaagaaattt caagtcattg aaatattcca ttgagatttc 4920
ctaaagggac aaaattggga aaataagaaa ctacgactta gatttggcta cgtagtagaa 4980
agtatctccc ctacatacat acaggcaatt gtatgtatga atcatagggt atatgtgtgt 5040
gtatactaca cacacattct tttaaagaga attcatggaa aaaaaagcag ttggagtgat 5100
cagatgtatt gcaaaaacat acagagaatt taaatgacag ttaataccaa gaaattagtt 5160
gggtttactt tatcaggtcg taataggaat cactaaagaa gttactagtg tgtctttagg 5220
accagtggca actcttaaac taaaactttg ggtccttatt atctacttac agaacaaagt 5280
gaaacaaaca atgattaagc tgattggata tacattcaaa gatatttaat gtaaagtttt 5340
ttggaatacg aagaaaattc agaaaataaa tattatcaac agttacttat tggcaaatag 5400
agaaagacaa gaatagttta gtgagcccgg tattttgttt ttatagtttt tatctcagtt 5460
gtacaactca caaaaccatg aagtctttgg tattttataa atgtttaaca aaatttacat 5520
cagattaagg catttagatg aaaattatta tgttctcact atcttccaaa ttttatttca 5580
tcctatctcc aaaatgattt cttagggtac aaaaagagca gacggggctg taaaaataca 5640
agcaaaaaac tgtgtgcccc tagtttcagg cagaacttaa actgtcagag gtactagcta 5700
catgatttgt tttttaactt tggattgttc acgtccaaaa atggataaat tacatttgtg 5760
tttatcatca gttgcatttt atgtattatt ttaataaata ctatctgaat gaagactatt 5820
ctaaaccaga aaattcccca aatccaaaag aaaaaaaaag tgggaagagg tgaaattgaa 5880
gtttgtgtat atgaaagtta tcttagacat atttttaatt ctccagtttc tgcaaaataa 5940
ttaaaatata cagtaactgg tctcctaaat cctgaattta atgtattaaa tacttatgtt 6000
ctttatattg gtgccttttt aaaatgcatt gagagtgttg gttagctgtt gcagctgtac 6060
aacactttta atatgcattt ttaaaaatca cttaaaattg agtactatat aattcatctc 6120
tgcattttta gtgcaaatct ttagagcaat ttctaataga gaaattttca gctcagctgt 6180
taaaaggaaa aggaaacttt gaaactagac tttactacct ttttagtttc atagtatttc 6240
tgaatatgat tacaagatta tgcaggtaaa atatagagtg aaactttacc tgtgaattga 6300
attataattt gtgtttttgt tttgttttta aggaagaata agttctgtat caaacaagaa 6360
tttattagat aattttttgg tcaataaaat acagtattca tttggatttt catctccaga 6420
ctagtattgt tctagtcttg gaatctgtat tttctaatct gttagaaaat agagattgaa 6480
aattgatgga ataatgtgaa aaagcaggta attaattctc cttgaacaaa gcaaaactga 6540
acagtcatat cacattgcta ttctccaaag cataatctca aatggtttca tatcatggtt 6600
gtgtattact tgcaatgggt gtgttaggat atgacagctt tttaaaaaaa tgagctgctg 6660
gttatacaaa gcaaatggca tatgaccaag aagctgtgat atgctagtgt ttctttttat 6720
catagtgtat tactaggcca aataatgaca ccttgaatat ttttacattt attgcagaaa 6780
ccttaaactt tggaatttcc ataaggtttt tatgtaatat tctatttcta gctttttagt 6840
tttatcttgc tgtactgtaa gtttgaggat atttttcacc tgcactctta ggaataagtt 6900
cataattctg tttatggggc tttcctccca taacactgca tttgtatatt ttctgtataa 6960
aatatgtgtt gtgtattaac ctttatccca tacagagagt ggtacatgaa tgactagttt 7020
tctaagatgt cctttttatt gtgaataaaa tataaaagtt aaaggccctc tgctaagtca 7080
cataaagtac agcatataag ttcatatagg tacaaataaa tgagtttgca gtgaattggg 7140
ccttcaaatt acctcaagtg acagatagta agaaaagctt cttgagcagg tggaggtcac 7200
tgaatcccct actatgcact taccaagatt ttacttactt taatttactg gaaattgatt 7260
ttttaaaaaa tgactacact gtaacaaggg aagggatctg ggtttttttg ttgttttatt 7320
cttgtttttt ttaagtagtt caaattctga aactgtgatt taaaaatttt ttacagtcaa 7380
gcattctgat tttgaacata actcccttcc ctttctgtgt aacaaaggtc tctctgttat 7440
ctcttaaatt ttgttacatc tccctcagcc tctttctttg tccgtctccc ttctgtcatt 7500
gtctatggat gtttacctct ctgttctcct aaaagtttga agattaggtc aactcttatt 7560
tctagttcat tggtaattta atcttaattt ttttttcgtg atttttgttg gttgtataat 7620
ctgctgacgt atttttatac tcaagtgtag ttttctatta aaaagaaaag tggttggatt 7680
aaaaatagta agctatgtaa ccctcatgtt actttcactt tcaaatattg ggtacctaaa 7740
acattacttc agagattatg taatcctatt atagtatgtt tgctttcctt tattgttgga 7800
ttttacattc tgatttggct ttcctccaaa aaatgtatat catgaaagac tagacagtta 7860
tttgcaagtg tttagaaagg tgttaaaaat gtaaagcaaa gagtcttaac tttctcctaa 7920
ttgggagaaa aatgctttaa cattactata ataatattcc aggtttggag ggggtctcca 7980
ggccccatat ttgctgttaa tagttggacc ttttagacca tgtgttattt gcaatcccag 8040
aatgattgct tctgctatta gttaaaaaga tactattctt ttctttctgt acaagtgcaa 8100
tactcccctt gaagtcttaa aaactatggt gatttttttt tcttttctga cctattcttc 8160
ctttagctaa tgacaaaaag aaactcataa aagtcatagt atgttaaagg acacaacaag 8220
caaagagaaa aacactccac aatcaaaaga ttacagaatg tggaaaccac tagtctgatc 8280
tcatggtatc tttatttaag ctaaatttcc atggaaatta gtaatctttt gcttgaaaaa 8340
tgtgtcctaa agttgaactt tttacagatt gaatcttctt agaccctcgc ccaatgctct 8400
aaattaagaa cctaatactt aatattttta ttttacttct ccccttttag aaataaactt 8460
ttaaataaaa gcaaagcact tagctgagtt ttaaacactt acatatcacc tattggagaa 8520
atttttttta aaaatatttg gagcagtcct gttttcatac aaatttaagt aagaggtatt 8580
tttcttatac atatttatat gtagtgtgct aattttcttt ttttatacct gtgtccctgt 8640
agtaaaactg ctgtaatata aatacatgtt ttgttaaaag ataacatttc tttggcattt 8700
cttttaaagg cagttactgc atttctgcat ttgtacagta tgtgtcttgg ccattttaga 8760
tattctttct ttaacaatac caaaggtaat tagactattt taaagactaa ttgcttgaca 8820
gtttctaggg tattttgtgt tttagaagca aaaaaagaaa aaaaaatagg tcaaaccagt 8880
aaacctcatt ttttttcaaa ctaataattt ggggaaataa aaactattgt ttaaaaaaga 8940
aatatatata tatatatata aatatatatg taaagttaaa attccatacc ttgtatgtca 9000
ggtttgctaa gtgtaatgta gtttttttaa ggctcaaata ccatacctca gaaaatgagg 9060
tttactatgg aaatactgaa acagtctttg cagctgtgtg acaagtcact ctactacata 9120
ctgatttgga gacctccgct aaatagtttt atcactgcag actaaaatgt gggacttgta 9180
tcttctttgt ttttaatgca cacacataca tgttctgtgc atgtatgtgg ttactgtgta 9240
tatgtgtatg agtgttgtat atgcatgtgt gagtgtgtgt ctgtatgtgt gtacaactaa 9300
agaagctgca gaaactttgt aatactttgt gaaaaggatt atattataaa ggtttgtact 9360
gtctgagtgc acagctactg gaataaattt agggaatctc aggaacaagc atataatttg 9420
tccaagattt atttcttctc agaagtgtaa gtgcagtttt taattctgta tattatttaa 9480
tattttacca ataaaataaa cttctgacat aaaaa 9515
<210> 26
<211> 9457
<212> DNA
<213> 小家鼠
<400> 26
tgtttgctgg attcggtctt ggaatgaccc acctgtaaag tgctttccct cctcctcggc 60
ttcaactctg cagggggctt tgcctggagg gggcagggag ggaagggggg ggggacacaa 120
aaaacttctt tctttctttc tttctttctc cgtttctctt cagcccgaca ttgtcacctc 180
ctccttgagg ggttagaaga agctgggagc tcccgacaga gctggaaatg gtgatgactg 240
ttttttaatc agaggacaat ttcttttcac tgcactttga ctatggaaac agacgcaatt 300
gatggctata taacatgtga caatgagctt tcacccgaag gggaacacgc caatatggcc 360
attgacctca cctcaagcac acccaatgga cagcacgcct cgccaagtca catgacaagc 420
acaaattctg taaagctgga aatgcagagt gatgaagagt gtgacaggca gcccctgagc 480
cgtgaggatg agatcagggg ccacgatgag gggagcagcc tagaagaacc cctaattgag 540
agcagcgagg tggccgacaa caggaaagtc caggaccttc aaggcgaggg aggaatccgg 600
cttccgaatg gtaaactgaa atgtgacgtc tgtggcatgg tttgcattgg gcccaatgtg 660
cttatggtac ataaaaggag tcacactggt gagcggccct tccactgtaa ccagtgcgga 720
gcttctttta cccagaaggg caaccttctg agacacataa agttacactc tggagagaag 780
cccttcaaat gtcctttctg tagctatgct tgtagaagaa gggacgctct cacaggacac 840
ctcaggaccc attctgtggg taaacctcac aagtgtaact actgtggccg aagctacaag 900
cagcgcagct cactggagga acacaaggaa cgctgtcaca actatctcca gaatgtcagc 960
atggaggctg ccgggcaggt catgagtcac catgtaccgc ctatggaaga ttgtaaggaa 1020
caagagccta tcatggacaa caatatttct ctggtgcctt ttgagagacc tgctgtcata 1080
gagaagctca cggcaaatat gggaaagcgc aaaagctcca ctcctcagaa gtttgtgggg 1140
gaaaagctta tgcgattcag ctacccagat attcattttg atatgaactt aacatatgag 1200
aaggaggctg agctgatgca gtctcatatg atggaccaag ccatcaacaa tgcaatcacc 1260
taccttggag ctgaggccct tcaccctctg atgcagcatg caccaagcac aatcgctgag 1320
gtggccccag ttataagctc agcttattct caggtctatc atccaaacag gatagaaaga 1380
cccattagca gggaaacatc tgatagtcac gaaaacaaca tggatggccc catctctctc 1440
atcagaccaa agagtcgacc ccaggaaaga gaggcctcgc ccagcaatag ctgcctcgat 1500
tctactgact cagaaagtag ccatgatgac cgccagtcct accaaggaaa ccctgcctta 1560
aatcccaaga ggaaacaaag cccagcttac atgaaggagg atgtcaaggc tttggatgct 1620
accaaggccc ccaagggctc tctgaaggac atctataagg ttttcaatgg agaaggagaa 1680
cagataaggg ccttcaagtg tgagcactgc cgagtccttt ttctagacca tgtcatgtac 1740
accattcaca tgggttgcca tggctaccgg gacccactgg aatgcaacat ctgtggctac 1800
agaagccagg accgctacga attttcatca cacattgttc gaggggagca cacattccac 1860
taggcctttt cattccaaag gggaccccta tgaagaactg cacatgaaga aatactgcac 1920
ttacagtccc accttccctc ggatggcgac atgctgtctt ctggatgctg tcactgtcta 1980
taattcttat tttgtggaca aaatgtcatt tgctctgcct aactacaatg aggaagaaac 2040
aaaagaaaag ggatgggatg ttcaatgata acttggcttg tttatttcgt gagcatttaa 2100
agcagttcat tgcagccatg catccttgtt aaggcctatc ataatttagg agatcattca 2160
gttcatagag gttcatccaa gagattctga tctgccattc atattcagga ttgtgataga 2220
aggcaggaaa gttgagagtt ttctgggtag gatgcttggc aatttaaaat ggtctaagtc 2280
attttactct caaagaagtt tcaaaatgta aaccgatttt attttctgtt cgttagagat 2340
catggaacac aaaaacaatg ttattttcca taactactag gatgagttga attgttgtgg 2400
gttctgtgtt tacctcccct acggaattta taattgagta tgttttacac tgtatcatat 2460
agcaaaaatt ttaaactaca ggtagtcaag ggccgctacg atacatctga ggtcctttga 2520
tcttattttt ctaaacttgg cgcactgttt ttccatagtt ttgatgactg gcattttata 2580
gacaccctgg cagccttact tttaacacct gtaacaaata gtatttttta tgtagttttc 2640
agaataacat atggtctcaa gagtgggtaa gaggcagtca gtaatttcca ggaagaattc 2700
tgcttttcac aatttgagat ttttttttaa gctgtaatat gatggcagct tagtatacat 2760
gtttgcttct aaaggtgtgt ttacgatcgt cactttatca gcattcaatc agtgttaaca 2820
agtcagcaga aaagtgtaat taggcgaaca gtagggggaa ttcccactct aagaaccctt 2880
ttctggtatt tctcttcaag ctgtgaccac tcagtgttct gtccacagtc cattcctctt 2940
tgactcttgg aatagaaggt cttaaaaagc cttgctagca gttgcttctt ttaaaatctt 3000
ggagcaactg ttaattggac ctgaaagtgg taacttgaac cctggaaggt cttttattta 3060
ctagggctat ttattccact atttcttcag taataagagt tactaccttt gctggagaca 3120
aaagggaact tctttgttac ctgaataaca tagtgcaggt caaacaaaca agcaaaaagt 3180
tttctttcag ccttcccgga gttgagaatg tgaccatctt taggagaagg tcccgcactt 3240
taaaaataaa aacaaaaaat ccaactctag agttccttat cagaaatgaa tctcaacccc 3300
ttagtcaaga attttctgtc gtctcttaat ttgcacgtga gaaatacttc catatctcat 3360
gctcaggttt taatctgatc tttgtgagtt ctcaattgtt tttttttttt tttttctttt 3420
tcttttctga acttgacttg catttgtggg taggattgga gcacactgtt atcaaggcat 3480
tcgggggaat caacttggca gacataactt gctgcttgtg tttgaggaaa acaaacctga 3540
ccataactgg attatttgac agtcatttgt aaatgctgag aggtctgctg tgtggtaaca 3600
catcgctgct ccaacagtcc cttgagtgac atgcccaaac catgtcactg cactttgcct 3660
tgggaagtac cacgactgga gaagtaccca cggatgagca gtgtgctccg aactcgcttt 3720
gcaggtttct gtctgatcat ttaaggaact tcttagctct tccatagcca gagcgaggta 3780
gttctgactt gcctctttta ctaatcctta tcttagttct ttctggagaa atatccaact 3840
ggttccttaa catgtaagag aatgcaccaa accagagcta tatcaaatgc caattgttgg 3900
ttttgttttt ttttttttgg cggggggggg ggggggggtt gtatcccttg gtacatttta 3960
aaaacatagc ttcctcgggg atgaaacatc tcatcatgcc ttccctatcc ccacttaccc 4020
tacacactct ggaatcacag tgaaaaggat atttatttct gaatgaggta aataagttta 4080
aggctcctga cttctttgtt ttaactgcaa cttgaggaag catctggatg tctgtcagtg 4140
tgtccctttc ggctctttgt gaacacctgc aggcatctgc tatctcttcc ttctctctgc 4200
tagcacctgc tctattaaca atcatgtacc tacctgccct gggatgacac tgaatttagg 4260
tgtactggaa gagttgtgtc cttcccctac gaaggtggta ccgatgtgct ctgcctttct 4320
gatcccattt tattggaaaa cctgatgtac tcaaaggcgt gaactataag ggtagattgg 4380
ctgtacatat gcacttagcc ttttctttct ttttcagctg catggcacaa gatacagaaa 4440
aaaaagtaga tagctctgct gtgacaggga caaatgggga caagctgaat tcaagatttg 4500
tgggttacga taaactttgt ggacatagtg ctgtctgagg gaccctcaat gactgtattt 4560
gcctcttttt caccaaagag aataggagac atggtagcac ctaaaaatag gtatgaaggc 4620
cagataccaa ataaatcaaa tttacataac cgttacaaga ccagtttatt taggtgacat 4680
tttacagttg agagagaatt tgaggggcac gaaaatgggt tatcctctgt gttttccagt 4740
ttgtcaggaa tttatcagat ggctctgccc taattttgcc cagatttttt tttttttatc 4800
accagttcct tctggagaaa catgctgcgt ctctatagta gtgattgatt gcttgttata 4860
aaggcttttt agaacagtga gagccgccag cccaatgagc ggtagaggga agtgtgaaac 4920
actgtcattc aaacattccg ttaataattc tctggataaa atggggatgt gagggccaac 4980
cattaagatt tagaatgaag ttggctgcct ggctggcata catacaggtc agtgtttgaa 5040
tgcagtacag tttgcatgca catgcatatt gcacattctt ttaatgaaaa ttcacagaaa 5100
agaagcaatt agcattgcca gttgtattac aaaagcttag agttagaagt acagtacagt 5160
tactacgcca gcagttgggt ctaattcagc aggttgtatt aagaaagccc catgttgtca 5220
gtgtgtcttt aaggctaatg gcaatttaaa tcacaaatct ccattgtctg catccagaaa 5280
aacaaacaaa gcaaggcaaa aaacaatgaa acaatgaaaa gatattgagt tgactggaga 5340
atatttgaag aaatatagat tttttttgtg agaggaagaa gttgcaggaa gtaatttagc 5400
aaccttggct tgtgtttgtg cttctctgac ccagttgcac acctcacaag tttggtcttt 5460
ccaaaccttc atcttctctc ctaaatgaca agttagggta gaaagattca tggaagaggc 5520
tggagaggac aaggagagct gtctgcccct agattcagga ctgcgcctta cactgtccaa 5580
gtcacctgcc acatactgtc ttagccttga aattgtagat tggtggtgat cgtcagttgt 5640
acttcatgtt attttaataa ctactgtctg tataattatt ctacagcaaa agctccccca 5700
aatccaaaag gggaaaaaag tgagggatga attgaaactt tgtatatata aaagttattt 5760
tataaatgtt ttagtcttcc agtttctgca aaataattaa aatatacagt aactggtctc 5820
ttaaaccctg aacttaatgt attaaatact tataaaattt tatattggtg ccttttaaaa 5880
atgcattgag agtgttggtt agctctttag ctctaccaca cttttactgt gtatttttta 5940
agaaaaaaaa aaatcacata aaatctaagt actctctaat tcacctttgt gttcttagaa 6000
gaagaagaaa aaaactgcta aaagaatttc cagactttta gctgagctgg caaaagtgac 6060
aaaaaaaaaa aaaaaaaaaa caaactttga aaccagattt taatcttttt agcttgatga 6120
tatttctgga cattattcta tggtagaggc aaaatagaag gtagactcac atatcagcaa 6180
tgaattggat tatgctatat gttttgattt cttcttgagg aagaatatgt tttgcatcac 6240
acaggggttt ctttgtataa tttggagtca gtaattacag tattgctttg ctttgtttta 6300
aatacccgac tgatgttact ctagtcttgg gtcttctgtc tcttctgtct tctaacctgt 6360
ggttgttttg tgaaatggcg tgggaatgca gatcattgtc tcctcttgaa caagacaaag 6420
ctcagcacac tagtcccgtg actggtctcc aaaatgtcat ctcagatgtg tagtctgggg 6480
tcgtctgtca cttctaaggg gtgtcttcaa ctatgacagc tttttaaaaa cgagctgctg 6540
gctgggtaaa gcagacatca tatgaccaag aagctgtgat acgctagtgt ttccttctgt 6600
catcgtgttg tactcttagg ccaaataatg acaccttgac tgtttttaca tttactacag 6660
aaacctaaac ttttggaatt ttcaaaggtt tttatgtaat gttctatttc acagcggttt 6720
ccttttctct tgctgtactg agtctgtgag tatttttttt ttcagatgca ctcttggaaa 6780
taagttctga attctgttta tggcgtttct ctcgcttgac actccgtgta tagatgttct 6840
gtataagttt gttatgaatc cacctttctc atgtatggac agtgagaagt acatgaacaa 6900
ctagtttcct aagatgactt ttatattatg aattaatatg aaatttacag gtcatgtgca 6960
ccttaagtgc agaatcaaaa cttcctatag gtccacataa gcagttctca gtgaaccggg 7020
ccttcagttt acctcaagtg acatgtagta aggaaagccc gggaacatgg aggtcactct 7080
ctgcagcaca gtgcacttag tagcatgttg ctgaatctca gttacagaaa atggatattt 7140
aaaggaacac actggaagga tgcaagggat tgagggactg ctgatatttt cgttgttgct 7200
gttgctttgt gcttttcaaa aagttgttca aattatggaa ctgtgatcta aaaacggttt 7260
gacagtggag caccagagag gatgtccacc actcacttgc ccttcggtac gactaagctc 7320
tgagtttgcg tcttcaactc taccttcctc tcccctcctc atccctactc tgtctgtggc 7380
cctcctctcg gtgtcatttc ctcttggtgg ctctcttgac actcctacta gttaggaggt 7440
caactctgaa cttctgactc attaaatctt aatttttgtc tcagtggttt tagttagctg 7500
tgtagtctgc tggcgtattt ttatacccac gtgtagtttt atatttttaa agcgtggttg 7560
agttgacatg gtgcactccg tagtccttat tttgcttcac tctcaagtag gaggcaccta 7620
acgtgactcc agaaattctg taatcagagt atccgtctgg ctcctttgtg cttggatttt 7680
gatttgtttg gctttcttct taaatacaaa tcatacaaga gtagactttc cccccaccat 7740
agaggataaa aatgtaaagc aaagagtctt aactttctcc caaccggggg gcggggcgag 7800
tgctgtccca cttctgcagt gatgttccag gctcagaggg gtctccagac cccaggcttg 7860
cctgtcatcg ggtctcttcg accctgttat ttgcagcttt gggatggttt cttttgctat 7920
ggagtttaac agctcttctt ttttccataa aagtgcaata cccctcttga agtcttaaaa 7980
actatggtaa ttttcttctt ttctttctct gacatttgtc tcattagcca atgatgaaaa 8040
gaaatctttg gaaattctaa catgtcatag gacataggca aatatggaaa ccactctgct 8100
atgaaaagtt gaaaaaaaaa acgtattaac aaacgactcc tctgactttc tagaaacttc 8160
gtttagacta aattttcttt gaaatcatga atgaaagttt atcctgaggc tgaaatataa 8220
tttttctccc actcttgtct aatgctctta agttaaataa ctaatattta atgttttcat 8280
ttctctcatt ttggaaaata aatatcaaag cacttaggtc aggtttaaat caatattacc 8340
tgttggaaaa aaattttttt acatatttaa agcagacctg tttcaatgca gatggagaag 8400
tatcttttgt attattcata tttatatgta gtgtgttctt ttcttttttt aatacctgtg 8460
tttctgtagt aagactgctg taatgtaaat acacgtttta ttaaaaagta acatttcttt 8520
ggcatttctt ttgatggcac atactgtatt tttacagtat atgtcttggc tacttaactt 8580
ttttttcttt aataatacca aaggtaatta gactatttta aggactaatt gcttgacagt 8640
ttctagacta ctttgatttt tttagaagaa aaaagaaaaa aggataaaaa aaagtcaaac 8700
cagtgaacct cattttttca aactaataat ttggggaaat aaaaactatt gtttaaaaag 8760
aaatatatat aaatatatat ataaatatct gtaaaattaa aatcccagac cttgtatgtc 8820
aggtttgctc agtgtaatgt agggtttttt tttgttttgt ttttgttttt gtttttaaag 8880
gctcaaatac ctcagaaaat ggggtttact atggaaatac tgcgacagtc tctgcagctg 8940
tgtgagctgt cattctgctg catactgatt gggagacctc cactaaacag ttttatcact 9000
gcagactaaa atgtgggact tgtattttct ttgtttttaa tgcacacacg tgcatgctct 9060
gtgcgtgtat gtgggtaccg tgtatatgtg tgtgagtgtt gtatatgcat gtgtgaatgt 9120
gtgtgtgtgt gcgtgcttgt gtgtgtgtgt gcgtgcttgt gtgtgtgtgt gtgtgtgtgt 9180
gtgtgtgtac aactgaagaa gctgcaaaaa ctttgtaata ctttgtgaaa gggttatatt 9240
ataaaggttt gtactgtctg agtgcacagc tactggaata aacttagcca atctcaggaa 9300
caagcatata atttgtccaa gatttatttc ttctcagaag tgtaagtgca gtttttaatt 9360
ctgtatatta tttaatattt taccaataaa ataaacttct gacagaaatt atttggtaca 9420
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa 9457
<210> 27
<211> 9788
<212> DNA
<213> 智人
<400> 27
aaccccgcgc accggcaggt cgccggctcc tgcccttttc agtctgcgcc gacgcggctg 60
ccggatcccg gggactcccc gcgccgggaa tctcccgcca gctgcgcgct gagtccaggc 120
gacggcagga gcacgtggag aggccgagta gccacagcgg cagctccagc ccggcccggc 180
agcgacatgg aagatataca aacaaatgcg gaactgaaaa gcactcagga gcagtctgtg 240
cccgcagaaa gtgcagcggt tttgaatgac tacagtttaa ccaaatctca tgaaatggaa 300
aatgtggaca gtggagaagg cccagccaat gaagatgaag acataggaga tgattcaatg 360
aaagtgaaag atgaatacag tgaaagagat gagaatgttt taaagtcaga acccatggga 420
aatgcagaag agcctgaaat cccttacagc tattcaagag aatataatga atatgaaaac 480
attaagttgg agagacatgt tgtctcattc gatagtagca ggccaaccag tggaaagatg 540
aactgcgatg tgtgtggatt atcctgcatc agcttcaatg tcttaatggt tcataagcga 600
agccatactg gtgaacgccc attccagtgt aatcagtgtg gggcatcttt tactcagaaa 660
ggtaacctcc tccgccacat taaactgcac acaggggaaa aaccttttaa gtgtcacctc 720
tgcaactatg catgccaaag aagagatgcg ctcacggggc atcttaggac acattctgtg 780
gagaaaccct acaaatgtga gttttgtgga aggagttaca agcagagaag ttcccttgag 840
gagcacaagg agcgctgccg tacatttctt cagagcactg acccagggga cactgcaagt 900
gcggaggcaa gacacatcaa agcagagatg ggaagtgaaa gagctctcgt actggacaga 960
ttagcaagca atgtggcaaa acgaaaaagc tcaatgcctc agaaattcat tggtgagaag 1020
cgccactgct ttgatgtcaa ctataattca agttacatgt atgagaaaga gagtgagctc 1080
atacagaccc gcatgatgga ccaagccatc aataacgcca tcagctatct tggcgccgaa 1140
gccctgcgcc ccttggtcca gacaccgcct gctcccacct cggagatggt tccagttatc 1200
agcagcatgt atcccatagc cctcacccgg gctgagatgt caaacggtgc ccctcaagag 1260
ctggaaaaga aaagcatcca ccttccagag aagagcgtgc cttctgagag aggcctctct 1320
cccaacaata gtggccacga ctccacggac actgacagca accatgaaga acgccagaat 1380
cacatctatc agcaaaatca catggtcctg tctcgggccc gcaatgggat gccacttctg 1440
aaggaggttc cccgctctta cgaactcctc aagcccccgc ccatctgccc aagagactcc 1500
gtcaaagtga tcaacaagga aggggaggtg atggatgtgt atcggtgtga ccactgccgc 1560
gtcctcttcc tggactatgt gatgttcacg attcacatgg gctgccacgg cttccgtgac 1620
cctttcgagt gtaacatgtg tggatatcga agccatgatc ggtatgagtt ctcgtctcac 1680
atagccagag gagaacacag agccctgctg aagtgaatat ctggtctcag ggattgctcc 1740
tatgtattca gcatcgtttc taaaaaccaa tgacctcgcc taacagattg ctctcaaaac 1800
atactcagtt ccaaacttct tttcatacca tttttagctg tgttcacagg ggtagccagg 1860
gaaacactgt cttccttcag aaattattcg caggtctagc atattattac ttttgtgaaa 1920
cctttgtttt cccatcaggg acttgaattt tatggaattt aaaagccaaa aaggtatttg 1980
gtcattatct tctacagcag tggaatgagt ggtcccggag atgtgctata tgaaacattc 2040
tttctgagat atatcaacca cacgtggaaa agcctttcag tcatacatgc aaatccacaa 2100
agaggaagag ctgaccagct gaccttgctg ggaagcctca cccttctgcc cttcacaggc 2160
tgaagggtta agatctaatc tccctaatct aaatgacagt ctaagagtaa gtaaaagaac 2220
agccataaaa taagtatctg ttacgagtaa ctgaagaccc cattctccaa gcatcagatc 2280
catttcctat cacaacattt ttaaaaaatg tcatctgatg gcacttctgc ttctgtcctt 2340
taccttccca tctccagtga aaagctgagc tgctttgggc taaaccagtt gtctatagaa 2400
gaaaatctat gccagaagaa ctcatggttt taaatataga ccatcatcga aactccagaa 2460
atttatccac tgtggatgat gacatcgctt tcctttggtc aaggttggca gagcaagggt 2520
ataaaggggg aaattgtttg gcagcaccaa cagaaaacaa acaaacaaaa aacagctacc 2580
taaaacttct tgaaagagtt catggagaat tggtgataca gacccaaagc aaatttgcca 2640
atgatatttt ccacaaaaaa agtccaaaaa gtatggctca gcctccccct ccccacagga 2700
gaggaattgg agatagatgg catgtgtgtt tagatcggag ttgagctccg gaatggggtg 2760
aggagggaca cctctattga gaggttctcc ttgatcaggc aggcttcggc cctttttttc 2820
ccatttaaat ggaactgctg tattccatga aaattcctga aagtctgatc acggttctgc 2880
agatgtataa gtcatccttg tcactcataa tatgtacata ctatcaggag gagtgctgtt 2940
atcatggtaa aattagcact ggaataggag gtcacaaaat gctggctaat tagctatgtg 3000
actttgagaa atcgtttaac tttttttttt tttttttttt tgagacagga tctcactctg 3060
ttgcccaggc tggagtgcag tggtgcaatc atggctcagt gcagcctcga cctccccagg 3120
ctcaggtgat cctcccacct cagcctcttg agtactggga caacaagtgc acaccaccat 3180
gtctggctac attttgttct ttttgtagag ataggggtct cactatgttg cccatgctgg 3240
tcttgaactc ctgggctcaa gcaatcagcc cgcctcagcc tcctaaagtg ctgggattac 3300
aggtgtgagc caccacaccc agccttattt aactcttaaa actcagtttc cggccaggct 3360
cggtggctca cacctgtaat cccaacactt tgggaagccg aggcaggcgc atcatttgag 3420
gtcaggagtt cgagaccagc ctgacccaca tggtgaaacc ctgtctctac taaaaataca 3480
aaaattagct gggcagtagt ggcacatgcc tgtaatccca gctactccgg aggctgaggc 3540
agaaaaatcg cttaagcctg ggaggttgag gttgcggtga gtggagatca cactactgca 3600
ctccagtctg ggcgacagag tgagaccctg tctcaaacaa aacaaaacaa aaacaaacaa 3660
acaaaaacaa aaaaaactca gtttcctcat ccataaaata ggaattagat ttcaatgttc 3720
tcttaggtcc cttctagctt taattcatat gtgattatgc agtaaccaca aggtattttt 3780
taaacctcct aatgtatgga tattaagcag aagagtattt atatgaatac atgtttcaca 3840
ttcctttggt atgaaaatgg tgtgttaagt ttttccttta accactgagt tgtgaatgtg 3900
aagaaggtgg tggagaggaa caaaaaacag aaaggtattt tgatcttgcc acaaagcata 3960
cacacaaatt ggcacatgca gctgtttgcc aaagccttct tttttttttt actttttaag 4020
aaattatgtt agggaaaata aattctgctt ccagggacaa cttcatggag cctatttaca 4080
aattaagagt cagcttaatt tgtaacattt ctaccagagc caagaatccc aaattcctgg 4140
tagattagtg ttttatttct aaggggctta tgcattcggc tccaactcaa ctcgtctatg 4200
tgctgccagt aattaaaatg ttccacctca gactgcacaa atggcttatc cttctttgtg 4260
gcatggcgtc tgtctcagga aaaaaggttt tatgaaattc catggcaaca gtcccaacat 4320
gtttgagact tcagctaaag gaatggatgt attttggtgt gtagtcttca gtatatcact 4380
gtatttccgt aatactagac tccaagctat gccagattgc ttattccctt tgtgaaagag 4440
gagttgctca ttacgttctt gaaatatcgc acatcctgtt ggttcttcaa gggacaagag 4500
aaagagaatt tggaagcagg gattagtaga agagaaaacg agggaaagga agcctttcca 4560
ccagattagt gttcaagtct ttgcagagga gaccaacttt ttttgttttc ttttgttttg 4620
agacagtctc tcgctctgtt gcccaggctg gagtgcagtg gcgcgatctc ggctcacggc 4680
aacctccgcc tcccgggttc aagcaattct cctgcctcag cctcccaagt agctgggatt 4740
acaggtgctc accaccaagc ccggctaatt tttgtatttt tagtagagac aaggtttcac 4800
catgttggcc aggccagtct caaactcctg acctcaggtg atctgcccgc cttggcctcc 4860
cacagtgctg ggattacagg catgagctac cgcacccagc ctgagaccac cttttgcatc 4920
tcaagattgt gaaaccaagg cccattccac cagcctgggg actcttttta tagatatgat 4980
cctccttttt cctgtgacta atgaatttgc tgcatgattt ctattcttct gaggttagtt 5040
ttctgagtaa ggtgaccact cacaaaggca ctttctttgt ggcattctga gcctagattg 5100
gggcccatca attccagaaa aaatttatgt gtggaaactc tgcatcctta agtcttgaag 5160
ttgaaccaga tatgcagtgg ttaccatcac acagataaac gctgccttct gtacataccc 5220
cttatgctgt actaattaac aaaccccttg ccagggctgg ggaggtgagg gtgaaggaga 5280
atcttagcag aagggcagag tcaggacttg catctgccac tgctgggcac tgaagccctg 5340
gagcagcttc agatagtacc tgtactttct catgcagact ccctctgaac aagagccttg 5400
taggcccctc tccttcattt cccaccagcc tcttatcagg cgggctttcc accatacacc 5460
caggaggcca cggtctgagg aacaaccaaa cccatgcaaa gggccgggcg cgatagctca 5520
cgcctgtaat gccagcactt tgggaggctg gggcaggcag atcacctgag gttgggagtt 5580
cgagacctgc ctgaccaaca tggagaaacc cccatctcta ctaaaaatac aaaattagcc 5640
gggcgtgatg gcacatgcct gtaatcccag ctactcagga ggctgaggca ggagaatcgc 5700
ttgaacccgg gaggcggagg ttgcggtgag ccgagatggc accactgcac tccagcctcg 5760
gcaacaagag cgaaactctg tctaaaacaa aaacaaacaa acaaacaaaa aaacccaggc 5820
aaagtttcct tgcagccaag gtgacagaac tgggctgagg gtggaaaaga aacagaacca 5880
gtgctccagg tgttttttaa ttttttaatt tatttttatt ttttttgtat atgtatatat 5940
atgtatgtat attttagagg accagggtct cactatgttg cctaggccag actcaaactc 6000
ctgtgctcaa gcaatcctgc ctcagcctcc caagtagctg ggattacagg catgcacaaa 6060
caatgcccag ctctccaaat gttttctgtc actacctgaa gtgttgcatc ggtacttcct 6120
acggaaagaa aactaaatag aagtgtctct cccgtgagcc cccaccacta ccaccagaaa 6180
aaaaaaagag agaaaatgaa ctcatcagtc tttagtttcc tcaagttatt ctcccaaaaa 6240
gacattcgcc ttggcacaga taagccagct aatcttatgc tttatgaccc actgtgagct 6300
gttcctgaca cagcttctga ctttgtcagt gacaaaattt ctcacctttt aaatgcagtg 6360
cttaacattt tgttaggccc atactcaaaa tcggccagat ataaaatgac ctcagatttt 6420
gatctcctag gctcaaacaa tcctcctacc tcagcctccc aagtagctgg gactataggc 6480
acaccaccat gcacagctaa ttttttttgt atttttctgc agagatggcg tttcgccata 6540
ctgcccaggc tagtctcaaa atcctgggct caagcaatct gcccacctca gcctcccaaa 6600
gtgctggaac tacaggcaag agccactgcg cccagccaca acctcagatt tctttggcaa 6660
acagaaatgt ttaaaaacac aaaattttgc tcaggtgaaa cactgtgtta ctatcaaatc 6720
tcacatccac ataaagtttt tcttttcggc tttgtttcgt gaggaacaga cagaacaaag 6780
tttttccagg tagcatctgt atcactatta ttctcctatt tcctgtacca cccccacctc 6840
cccaagccct actgaatgtg aggtttagaa tgttttaagg agggtcaggt gcggtggctc 6900
acgcctgtaa tcccagcact ttgggaggcc aaggcgggcg gatcacctga gtttgggagt 6960
tcgagaccag cctgaccaac atggagaaac cctgtctcta ctaaaaatac aaaattagcc 7020
aggcgtggtg gcacatgcct gtaatcccag ctacttagga ggctgaggca ggagaatcgc 7080
ttgaacccag gaggaggagg ttgtggtgag ccgagatcgt gccattgcac tccagcctgg 7140
gtgacagagt gagactccat ctcgaaaaaa aaaatacaaa aattagctgg gtgtggtggt 7200
gcacacctgt aatcccagct actcgggagg ctgacgcagg agaattgctt gaacctggga 7260
ggtggaggtt gcagtgagcc gagatcgcgc cattgcaatc cagcctggac aacagagtga 7320
gactccatct caaaaaaaaa aaaaaaaaga atgttttaag gaaaaaaata gtactgttac 7380
atataatccc aggtgataag accacaatgg aaatgtttaa gtcctcactt taaagagtac 7440
cccactgaga agaggtatgt tggactctag cagagatttg gaaactctgg gacactcaag 7500
atgtgaaaga gcctggctat ctgaggactc aaagagtcag catcgggact tgtgagctca 7560
agaagagaaa agggagtggt gaaactttgt cctaaaagtt agcaccagga acagaagaaa 7620
aaaacccgat atatagtgat acctcatctt ttagagaatg ggaagctatt tttgtgttca 7680
cacagaaagt atagttcaaa aaacctctat atccagagtt cagacaagga gaatgatttg 7740
agatataagt gccgatgaag gaggtcaatt ttgatctgaa accagcagct ggacctgggc 7800
cacctcagga aaaggactct gttctccaag gcagcacgac tgaatggttc tgagaataag 7860
ccagggttca ggactcctga ccctttagga ccatggactc agaagagcct gaaggacaat 7920
tgtgggcttt aaacttctga gagcttgtaa agtaacacaa gactgtgcct ctcccttgcc 7980
ccagctgtag atagtctttg ccccaccatt gttatgaaga tacacagggt tttgcagttt 8040
gaataaattg gatacaagtt tcctcttttt ttttttcttt ttgagacaaa gtctcgctct 8100
gtttccccag gctgagtgca gtggcacaat caaggcttac ttgccgcctc aacctcctgg 8160
gctcaagcaa cgagccatcc tcccgtctta gcctcccaac tagctgagac tacaggcgtg 8220
ggtcaccaca cccagctaat ttttgtactt tttgtagaga cagggtctca ccatgttgcc 8280
caggctggtc ctgaactcct gggctcaagt aatctgccca cctcagcctc ccaaagtgtt 8340
ggggttacag gcgtgaggca ccgcggctgg cctgagtttc ttcttaatac tgtatcacaa 8400
ttgtgggctg tcttatgtgt tgatatcgat tgagctattt gaaataggaa tgttaatggg 8460
tgtattaaat ttttgtaagg atataacaat atctaccttc caaggatgtt gtgaggtttt 8520
ccatgatttt gtatatgagc taatgttacc tttgaggggt ggtgtgcatt atgttggatg 8580
attgtaaatt ttcagtggaa aatgtaccgt gtcctaaatt taaagacatg aaaaatatcc 8640
caagatcata ctagatcata atagcaattc ctttacaaat gaattatgga ggtaactgat 8700
ctctaacagt ttccttcatg ttgttttaat gcacaagggc agaggatctg ctgacccttg 8760
gaaccagcgt gagctaacca cgtgctatag acacttcatg gtgtcgcacc cagggaagtc 8820
aaagcgcttt gctccctcac tgtctgtgag tcctcagcca ttagtacccc accccccgct 8880
gctccaaaac ttgagttatt tcaaatgttt ctcactgttc atctctccac tgaccccact 8940
ccagaaagcc tggagagagt cccaagatgc cacccacctt ccccaatccc tcgccacaga 9000
tctgtgtcta tctcacactc tgtaagtgcc gctttgcttc ttcctctctt gaaaagactg 9060
agaacacaca ttttaacatg ttaggaaaat ggggcagcct aaaaaatgac tgatcccacc 9120
gccagtgact catgtatact ccaggctagc agacaaggcc ctttttggtg ggcctgcttc 9180
tgtgggttca cagaaaccaa attactgtgg gttgcaaaga attagcaggt catttacaaa 9240
gcagacatcc cttcacccag actgtggttt tgcatgctca ggttctcagt ctatgagctt 9300
tggtgcagga tcattttggc tactggaaaa accatagctt attttaaatt tctggttgcc 9360
aaagccacca cacgtgtggt ctgtggatga ccattgtctg cagaatgacg aggaaggaac 9420
agaatgtggt ttggggctca gggtggcctt cccactggga gggaaggcgg gagggagccc 9480
ttgccctggg ttttgacaca gcctgtgctc acagcctctc ctctcatctg catttctcag 9540
aaatgccctc cctgcccagt ggtgactttc cctcgtcact cctatggagt tctacctgga 9600
gcccagccat gtgtggaact gtgaagttta ctcctctgta aagatggttt aaagaaagtc 9660
agcttctgaa atgtaacaat gctaaccctt gctggaaccc tgtaagaaat agccctgctg 9720
atagttttct aggtttatca tgtttgattt ttacactgaa aaataaaaaa atcctggtat 9780
gtttgaaa 9788
<210> 28
<211> 4098
<212> DNA
<213> 小家鼠
<400> 28
ttccacgcga tcagggttcc tcaggcttga cattcaaaag tgggtgcgga acccgcggca 60
ctcggagcgt gctttaaagc ggccgccagc cagcgccgct ctaacctcgc gccccggctg 120
ccggcggctc ccgccctgca tctgcgccga cgcgaccgag cgatcccggg gcctccctgc 180
gcccggaatc tcccgccagc cgcgcgggtc cccacggcag cagcacgtgg agcggccgcg 240
gagcctgagc gacagctgca gcccgcgcgg cccgcggcga catggaagat atacaaccga 300
ctgtggagct gaaaagcacg gaggagcagc ctctgcccac agagagccca gacgctctga 360
atgactacag cttgcccaaa cctcatgaga tagaaaacgt ggacagtaga gaagccccag 420
ccaatgaaga cgaagatgca ggagaagatt cgatgaaagt gaaagatgaa tacagcgaca 480
gagatgagaa cattatgaag ccggagccca tgggagatgc agaagagagt gaaatgcctt 540
acagctatgc aagagaatac agcgactatg aaagcattaa gctggagaga cacgtgccct 600
atgacaacag cagaccaacc ggtgggaaga tgaactgcga cgtgtgcggg ttatcctgca 660
ttagcttcaa cgtcttgatg gttcataagc gaagccatac cggcgaacgc ccgttccagt 720
gtaatcagtg cggggcatct tttactcaga aaggtaacct cctccgtcat attaaactgc 780
acacggggga aaaacctttt aagtgtcacc tctgcaacta cgcatgccaa aggagagatg 840
cgctcacggg acaccttagg acacattctg tggagaagcc gtacaagtgt gagttctgcg 900
gaagaagcta caagcagaga agctccctgg aggagcacaa ggaacgctgc cgagcttttc 960
ttcagaaccc tgacctgggg gacgctgcaa gtgtggaggc aagacacatc aaagccgaga 1020
tgggaagtga gagagctctc gtcctggaca gattagcaag caatgtggct aagcgaaaaa 1080
gctcgatgcc tcagaaattc atcggtgaga agcggcactg cttcgatgcc aactacaatc 1140
ccggctacat gtacgagaag gagaacgaga tgatgcagac ccggatgatg gaccaagcca 1200
tcaataacgc catcagctat ctaggggctg aagcccttcg ccccttagtc cagactccgc 1260
ctgctcccac ctctgagatg gtcccagtca tcagcagtgt gtaccccata gcacttactc 1320
gggccgatat gcccaatggg gccccgcagg agatggaaaa gaaacggatc ctcctgccag 1380
agaagatctt gccttctgaa cgaggtctgt cccccaataa cagtgcccag gactccacag 1440
acaccgacag caaccacgag gatcgccaac atctctacca gcaaagccac gtggtcctcc 1500
cccaggcccg caatgggatg cctcttctga aggaggtccc tcgctctttt gaactcctca 1560
agccccctcc catctgcctg agggactcca tcaaagtgat caacaaagaa ggggaggtga 1620
tggatgtgtt tcgatgtgac cactgccacg tcctcttcct agattatgtg atgttcacca 1680
tccacatggg gtgccatggt ttccgtgatc cctttgagtg taacatgtgt ggctatcgaa 1740
gccacgatcg ctatgagttc tcctctcaca tcgccagagg agagcacaga gccatgttga 1800
agtgagcatc tgtcctcaat gcgagggtca acattgtttt ttaaagctga tggtagcctt 1860
atccagtaga ctgaactcaa acccacagtc ccacccagtt ctgttagctc tcaatcatgt 1920
ccacatgaac agtcagggaa ataactgtct tcattcagaa actgtttgca gagctatcat 1980
gttactctgt gaaacctccc ttcccatcag ttgagtttga tgggatttaa aagccaaaga 2040
agtatctggt tcattatctt ttgtagcaat agacagccat ctactggagc tcccggccaa 2100
ttggaacagt cctccgtggg ccgcaggagt cattcactgg aatacagcag ccatatgtgg 2160
aaaagccctt tgatcctatg cccagatcca cacagcggaa gagccgccca gctgcccttg 2220
ctcttgggca ccaacacaag gcagaagcct tagcgtgtag tccccctccc ttcacgttct 2280
aacagcaagg aagaggtggc cgtacagtaa ggacctgctg atagtaatgg aagaccctat 2340
tcttggagca tcaacccact tcctatcaaa caaaactgaa gccacctgag caaggaccct 2400
tctcctttac ctacggtcac aagggtgaac ctcagatgat ttggcctgag ccagaccctg 2460
atcctcctgc ctccgtctgg aggaaaattc tactccagaa gaactgatgc gtttaaatat 2520
tgggtatcat tgaaaccgca gagtcatgca ccgaggggtg gtatttgtct cctttgattg 2580
ggattggtag agcaagtggt ggggacatag tttaagggta cagtgcctgc caggtacaac 2640
caccacacca gggggcaaag agggaagaaa gaaaatggag ggaagagagg ttggctgagt 2700
agagcgtgta aggttgactg gttggcaacc cttgtcacct tggtggagta ctggctgaaa 2760
ccccaaagaa catttgaaaa gtgatttttg gcaaaggagc caaaatgtgc tgcttagttc 2820
cccaccacct cccaccccac aggcgtgaga tcagggacag aaccacagat gttctctcag 2880
gacggtgtga catcacactc tcctgggtta gaaatgcatg gtttttatta tattactcta 2940
ttttcaaaac agggtctcct ggtgccccgg caagcctcaa actcattgct ggctgaagct 3000
gcccagcact ctgagcctcc tgcctcagcc tacagagtgc tgggttgaga gggttatcag 3060
caccgtggtg ttgggcttct gctgtcctaa agaggagctg ccacatccca ctgagagtct 3120
gggaaggctg atcttgttct gtagatagac caggtagtca cctttgtcac acaggcacca 3180
agacatcaag attcttggaa aaatgctcca taaacaagca ctggaatcga ggccaccaac 3240
cgtgcttgcc aagctcatat ttgcaactaa ttggttaact ctaaaagaca aatggcctca 3300
accataaaat aagagtagca tccaaaccct cttgatggtc acttctggct ttgatacatg 3360
attattcaat agccacaggt tttttgcttt tgtttttgtt tttttaactt cttgatgtgt 3420
gggcattaag cagacaagtc tgcgtgtgag aatgtgtttc atatgtcttt gatgtgaaaa 3480
tatagttgtg ttaagttttt ccttcagcta ctgagtcatg accatgaagg aggcgatgag 3540
gggggactaa ggacaggaag ggttttgatc atgcagtcgt gtatacacga gctggcatct 3600
gcagcagccg tgtacacacg agctggcatc tacagcttct tgccggagcc cttttcttcc 3660
tttcctttta aaagaacttg tgttagggaa aaataagttc tgcttacagg gacggcttca 3720
tggagcctat ttacaaatta agagcttagc ttttatgaac atttctgcca gagccaggaa 3780
tcccaaattc ccggtatgtt agcattttcc ttctaagggg cttatggatt cggctcttac 3840
tcattcatgt atacgatgcc agtaattaaa acattcctcc tcaaacacac aaatagctta 3900
gcctgccttg tagcatggtg tctgtctcag ggtaaggggg gtgggttatg agattccgtg 3960
gcaacaattc tgtggcaaca atcccgtgtc agcttaaggg ctaggtgtct tcagcacatc 4020
tctgcatctc agcagaatcg gatgtgagct gcaccacatt gttcatgccc actgtgaaag 4080
aggacctgcc tagtctag 4098
<210> 29
<211> 4553
<212> DNA
<213> 智人
<400> 29
agcaggctgc cggctcggac ggcggcgacg cggcaggaca gggcggataa gaaggagcgg 60
ccggagactg gagctgggtt cgtggcgggc cggctgatcc ggacggagac tcaacctctg 120
tatggctttt caattttagt tgaaattctc tctccatggc cttttggagt cccttgctgt 180
atctccgaag taaatttcaa ttactctaca tttcatcaat gttggagtgg caagaaaaag 240
gaggaacaga tttggggtga aaagttttgt tttctaggtc taacaaactg taaatgttaa 300
aaaagcaaag atgggtgaaa aaaaaccaga gcctttggac ttcgtgaaag attttcagga 360
atacctgact cagcagaccc atcacgtgaa catgatttct ggatcagtta gtggggacaa 420
agaagcagag gctcttcagg gagctggaac agatggtgat caaaatggac ttgatcaccc 480
atctgttgaa gtttccttgg atgaaaactc aggaatgtta gtagacgggt ttgaaaggac 540
ctttgatggg aagcttaagt gtcggtactg caactatgcc agcaaaggaa cagcccggct 600
tattgaacac atcagaatcc acacaggtga aaaacctcat cgatgtcatc tttgtccatt 660
tgcatctgct tatgagcgtc atctggaagc ccatatgcgt tctcatactg gagaaaaacc 720
atacaaatgt gaattatgtt ccttccgctg cagtgatcga agtaacttgt cccatcatcg 780
aaggcgcaag cataaaatgg taccaattaa aggtactagg tcttccttaa gcagcaagaa 840
aatgtggggg gttttacaga agaaaacaag caatctgggc tatagcagaa gagcactaat 900
caacttaagt ccaccttcca tggtggttca gaaaccagac taccttaacg attttaccca 960
cgaaatccca aatatccaga ctgactccta tgaaagtatg gcaaaaacca caccaactgg 1020
tggccttcca agggaccccc aagaactcat ggttgataac cctttgaatc agctctcgac 1080
tctagcaggg cagttgtcca gtctgccacc cgaaaaccaa aaccctgcat cccctgatgt 1140
agttccctgc cctgatgaaa agcctttcat gattcagcag ccctctaccc aagcagtagt 1200
ttctgccgta tcagcaagta ttcctcagag ctcctctccc acaagcccag aacctcggcc 1260
atcccatagt caaaggaact atagtccagt ggcaggtcca agcagtgagc caagtgccca 1320
cacgagcact cccagcatag gaaacagcca gccaagcacc ccagccccag ccctgccggt 1380
ccaggaccct cagcttctgc accactgcca gcactgtgat atgtactttg cagacaacat 1440
cctttacact attcatatgg gatgtcatgg gtatgaaaat ccttttcagt gtaatatatg 1500
tggatgcaaa tgtaaaaaca agtatgattt tgcctgtcat tttgcaagag ggcaacataa 1560
ccaacattga ttgaaaatag tcatatttta cttagttttg ctgtttttgt ggtttggttt 1620
tttttgtttt ttgttttggt catccctaat aaagtgtctg ctaattcaag gcttatacat 1680
tatatttata gaatataaat ttgtcagtgg aataaaattt cccctttttt tcataaaaat 1740
ctggtcaggg tcatttatat attagaacag ttagacacat tggtgtctct tttttccttt 1800
cctttcgaca ttggagaatt ggagtgcagt cataatctta caagatgttc atttgaattt 1860
ctcacattta tggtccataa aaacttcaag gcttatccat acttttgatg tttcaatatg 1920
cattgaactg gatgttattt ctgccatatt tcaaaatggt agaataaatt acagaattta 1980
ttactactca tttcagtgtt tagtacagaa attgccttaa aaattgctat taattgaaat 2040
atcatttagt tcacattcct taagttgaat cggtagtttc atttcaactg ataatagtaa 2100
agctatttca gtttagtaaa aattttcttt tttccacaag aggaaatgta aaacagttaa 2160
gacttgaaat tgaaaattct tttaatattt aaaataactt gtttattcaa tgtctaaaca 2220
catgtcagtt ttccactgga tttttatttt cacaggtaaa tacactagag tgctagatgc 2280
ctttttcccc tgtcagtttg actttcattt aaatccttca ttctgatatc attactgtta 2340
ggtgaggtgg ataactataa tgagaatctc ttattcttcc tattcctttg atgaccaaag 2400
agataaagtg aagtcatcct tattattaaa atgcagcctc caaacaaatt tctcaagatt 2460
ccttttcctt ccttctatcc attttctgcc cataatttcc aagaaaaggt gggtatggaa 2520
acacatgaga gaatgtgata gtgaagtcat atttacaaaa ctgagaacat gtccaaaatg 2580
gattcttgtc tcctcttcag aattagccat ttaaaatatt ttctgtgact tcaaattgta 2640
attcttattt gcagttttac cagtcttcat gtacagtgac gaaactgtgt agaaactaaa 2700
tcatcgcttt agtaagaaag gataaaaagg tgtggaagtg aatataaaat gcatctaaac 2760
atgacattta atttgtttat aaaaataaga cttactaaat atagagtaat tcattttgaa 2820
taggaggcta ttgtttttat attgtgtaat aactcacgta ctctgaagag agcttggtca 2880
aacaataaaa tacattgtta ctaacttggt ttcttttctg tgtactttgc aaaaattcta 2940
tttttaattt tgttcatatg ttgaatgtgc ccctaattgg catcttaaag agaatagtaa 3000
gcatctatta accaaaaaag aactctaata gtaaaggaaa gggaaatatt ggtggtatgt 3060
acccacaaaa cccccaagtg ccaagttaat ggaatctctg ctttcccttt cagatgctag 3120
aaagccactg taatgagttc ttgcagttta gcatccagtc taagctactg cattgtttaa 3180
agagcagcat caaggacact ttctccaaac tggaactctc ttctttgtca aatcttgtac 3240
tttaaaattc tacaattctg ttacattgtt gtttaaatca cagactgctc agatccattt 3300
tactgcagta gtttccaagt gtgtaacttg gctttagtat ttatcagttg ccagaaagaa 3360
acaggttgtc atttggaagt ttttgtggtt attttttccc atttttattc ttcagataaa 3420
agcagtaccc caaaatagaa aatgaaaatt ttcatgaaac aaagagaact cccttgttaa 3480
aaccagctta ttaactctgt attctgtcaa atgcattttt ttctaacaac tgaccatgga 3540
tgttgtgaag gtgcatttta atttaaacat ggaaaagatt tttttcataa ttacatacta 3600
gaatgtaaaa ttataatttt gccatgactt aaagagcaca gttgatatcc caaaggtttt 3660
gatgctaaga agctacagtt attctaaatg cactaaaatg tttgaggcaa atctacctta 3720
gaggcttttt tggtatggta ttttttaaaa tatttagatt ttatttaaat ttcctgtgag 3780
ttattctgta tttgaaaaga tgttcgtgtc ttcccctctg tattgaatgt ttcactcatt 3840
ttatttttaa tcaaatattt tatagaaatg agttgttggg aagagtttaa catgcactat 3900
ttatagtact ttgccgttaa caggcaatgt tctgaaacta aatttatttt tgttcagtga 3960
acataagttt agatttttaa agttggtaga taatttatct ccactaatat ttttttaaga 4020
aactgtgaag agattaactg ggaataattt tatttcagat tttactaatg tagtatgtag 4080
ctacaacttc ttgaacttca agttaaggct agacatttac tttgaaaaaa ttccactggg 4140
tgtttccagg gctatttcat tttagaaata agtgtttgcc attcttctgc aaaaactgga 4200
caaggggaat actacaaaaa atactcagag ataaaatcct catttcaagt tctacaaaat 4260
atttatcaaa tgaatgttaa ttttttttta attccctgct aaagacgttt tcattagtct 4320
tagagggtat atgctttcta gaacttgttt ttgttaacat gtgctttgat gtaaagaaca 4380
tattttgtat gcaaaacata acttgcatta tggttgtaca atacactata ttgtttaggg 4440
attccggaaa gcagtttaat gcagaaataa ctatatctag tatgcagttc atattgtgaa 4500
tgaagctttg cttttgtaat aaataaataa gactttctaa tgacaaaaaa aaa 4553
<210> 30
<211> 4440
<212> DNA
<213> 小家鼠
<400> 30
cagctgcgac gctgacgaac gctgaggcgg tggcggtggc ggcgacggca gtgaaaaggg 60
ctgtggggat tcctcggtgc ggttgtcagg agatataaca gactttcaac ttaaagaaag 120
aaagaaaaaa aaaagcacca agatgggtga aaagaaacca gagcctttgg actttgtaaa 180
agatttccag gaatacctga cccagcagac gcatcatgtg aacatgattt cgggatcagt 240
tagtggggac aaagaagcag agactcttca gggagctgga acagatggcg atcagaatgg 300
ccttgatcac ccgtctgttg aagtttccct ggatgaaaac tcaggaatgt tagtagacgg 360
gtttgagagg accttcgatg ggaagctcaa gtgtcggtac tgcaactatg ccagcaaagg 420
aacggccagg ctcattgagc acatcaggat ccacacaggc gagaagcctc acaggtgtca 480
cttatgtcca tttgcatctg cttacgagcg ccacctggaa gcccatatgc gctctcacac 540
tggggaaaaa ccatacaaat gtgaattgtg ctccttccgc tgcagtgacc gaagtaacct 600
gtcccaccat cgaaggcgca aacataaaat ggtaccaatt aaaggtacca ggtcttcctt 660
aagcagcaag aaaatgtggg gggttttaca aaagaaaaca agcaatctgg ggtatagcag 720
aagagcacta atcaacttaa gtccaccttc catggtggtc cagaaaccag actaccttaa 780
tgattttaca cacgaaatcc caaatattca gactgactcc tatgaagcta tggctaaaac 840
tacaccaact ggtggcctgc caagggaccc ccaagaactc atggttgaca accctttgaa 900
tcagctctct actttagcag gacagttgtc cagcttgcca ccagaaaacc aaaaccctgc 960
ctctcctgat gtagatgcct gccctgatga aaagcctttc atgattcagc aaccctctgc 1020
ccaagcagtt gtctctgctg tgtcagcaag tattcctcag agctcctccc ccacaagtcc 1080
ggaaccgcgg ccatcgcata gtcagaggaa ctacagtcca gtggcagggc ccagcagtga 1140
accaagtgcc cacaccagta ctcccagcat aggaaacagc cagccaagca ctccagctcc 1200
aaccctgccg gtgcaggatc ctcagcttct acaccactgc cagcactgtg acgtgtactt 1260
tgcagacaac gtcctttaca ctgtccacat ggggtgccat gggtatgaca gcccctttca 1320
gtgtaacgta tgtgggtgca aatgtaaaga caagtacgat tttgcctgtc attttgcaag 1380
agggcaacac aaccagcact gaacacaatc aacattgttc tcacttggtt tggccttttg 1440
ggagtttgta gtttggtttt tagtttgatc atccctaata aggtatatgc taatttaaaa 1500
tttatacatt ctagtctata aaatagaagt ttgatagtga aaaagggttt tgttaacttt 1560
tcataaaagt ctggtcaggg ttatttatgc attagatagt tagatgcatt gctgtctttt 1620
tcatttacac ctatgagagt taaagtacag ttgtaatcag tttcctacac ttgtccataa 1680
ggattcccag ggttatctgt actcctgatg cttcaggata tacattacag ctaatgttct 1740
ttctgccata tgtcaaaatg gcacacttct cataaaatct tttataacat ttcagtgttt 1800
atagacaaac tgcctttaag tttgctccta attaaaatac tattttcatt cacataactt 1860
aagttgaatt agtttcatta caaccaaaac cagtagttat ttcagtgtaa taaatatttc 1920
tcttcaagga gaagcataaa acagttcttt caaatttaaa ttataaaatg aaaatcttgg 1980
aagttgaaat ttggggctaa attgaaaatt gtgtttggta tttgagatat ctgttcattt 2040
aatgtgtaaa catgttagtt tttagctttt catttatata tgtatttata tattttgagt 2100
attattttaa agccacaggt aaatatacta gagtgctaga tgcctttttt caatctgatc 2160
tttcatgtaa attctgcatt cacctgttac tggtgtcagg taagattgac agccacactg 2220
attattttat tcttcccagt ctttgatgac caaagaggaa gtgagcgcat catcccactg 2280
agatgcttcc agagcctccg aggctccttt cctgccctct gtgcataatt gcccgtaatg 2340
tccacgaagg gttggtctag aaacccagag acgtaataag tgaggaaaca gctacaaacc 2400
cagagcatgc ccagacagag cctccttgcc tctccagagc agagcaggcc atggaaagtc 2460
ctccctgtga gtctttatgg acagagacgg tgggatcgtc accacagtgg gaaaggataa 2520
atagagttat tatgaagcac atttaaatgt gtcatttaac ttacttagaa ttagagtggt 2580
tcattttata taggaagcca ttatttttgt attgtgtaat aagtagctta ctctgaagag 2640
agcctggcaa aacaataaaa cattgtcact tactattggt ttctgtgtac cttgcaaatt 2700
tttcattttt atttggttaa tagcttgaaa atattctcaa ttggcttctt aaagaaatac 2760
cctgtcaagc atttattaac caaaaaatag cctcttacag taaataagag ggaactatga 2820
gagtgtctac ccgtgaagcc ccaagtgccc tggtaatgga cctgctctcc ctccctgtgc 2880
tggaaagcca ttccgagggt gcctgtgcgt acacagccag tcttggctcc tcccaactgc 2940
actgttaaag cgcagccccg aagacacttt ctagtgattt tggtctgttg cttaaatcat 3000
ttactagatt agttttaggg caacactttc caaatacata acttgactgt tgtgcttatc 3060
agctgccaga aagaaacagg ttattgttgg gaaaccttgc tgtttttaaa gtttgattca 3120
attaaaagca atacttccaa atagacagtg aaaacttccc aaaagaggaa gaagcccagt 3180
gtactgccgc acatctgtag tcccagctgc ttgaagcaga ggcgggaaga gtgctagagc 3240
ccaggaggtc cctgccaggc cgggcaacac tgcaagacac agtctcaaag gccaagcagc 3300
cgaaagggct ctcctcacag ccagctttat cacctctacg ttctgggcca aacagtgaca 3360
tgggcatttt ggttttccta acaactaacg atgaatgttc tgaaggtaca tttcatttta 3420
aatacggaaa aaacttttca taattacaga caagaaggaa aaacccccga ttttccaata 3480
atataaagag cacagttggt cttccaaagg tgtccatgtg tgaagctaca agtacttcga 3540
aatgcactaa aattttgaag caaatctacc ttaggaactt ttttgaaatt gtacttttaa 3600
aggtttaggc ttttgcttaa atattctgag ttaaattctg tactaggaaa gatgttggat 3660
tctttcctta aatactaaat aagttcctca tcttattttt aatcaaatgt tttatagaaa 3720
tgagttgaga aaagttgacc atgcactatt tatagtactt tgccataaca ggcaatgttc 3780
taaaactaaa tttatttttg tttagtgaac atgagtttag atttttaaag ttggtaattt 3840
atctccacta atattttttt aaagaaactg tgaagagatt aacagaataa ttttatttca 3900
gattttacta atgtagtgtg tagctacaac ttgacattca agtgaagact agacttctgt 3960
tttgaaattt ttccatcagg tagtttcagt ggtttcattt tagaaatgtg tttgcagatg 4020
tttgacaaag ggaatattac taaaaaagaa aagcaaaaaa aaaaaaaact tatcaaatga 4080
agaattgtta gaaaaattta aattccctgc taaagacatt tttgttagtc ttagggggta 4140
ggtatttgct ttctagaact tgtttttgtt gatagtattt gctttctaga acttgttttt 4200
gttgatagct ggatgtatgg aacctgtttt ctatgcgagg tgcaagtctt gcactacagt 4260
tgtaagatat attatattgt ttagggatca agaaagcaat ctatgctgaa gtaactatag 4320
tatgtagttc ctattgtgaa taatgctttg cttttgtaat gtattaataa aaagtaacac 4380
tttctaatga aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 4440
<210> 31
<211> 2008
<212> DNA
<213> 智人
<400> 31
gagacgaaac ttcccgtccc ggcggctctg gcacccaggg tccggcctgc gccttcccgc 60
caggcctgga cactggttca acacctgtga cttcatgtgt gcgcgccggc cacacctgca 120
gtcacacctg tagccccctc tgccaagaga tccataccga ggcagcgtcg gtggctacaa 180
gccctcagtc cacacctgtg gacacctgtg acacctggcc acacgacctg tggccgcggc 240
ctggcgtctg ctgcgacagg agcccttacc tcccctgtta taacacctga ccgccaccta 300
actgcccctg cagaaggagc aatggccttg gctcctgaga ggtaagagcc cggcccaccc 360
tctccagatg ccagtccccg agcgccctgc agccggccct gactctccgc ggccgggcac 420
ccgcagggca gccccacgcg tgctgttcgg agagtggctc cttggagaga tcagcagcgg 480
ctgctatgag gggctgcagt ggctggacga ggcccgcacc tgtttccgcg tgccctggaa 540
gcacttcgcg cgcaaggacc tgagcgaggc cgacgcgcgc atcttcaagg cctgggctgt 600
ggcccgcggc aggtggccgc ctagcagcag gggaggtggc ccgccccccg aggctgagac 660
tgcggagcgc gccggctgga aaaccaactt ccgctgcgca ctgcgcagca cgcgtcgctt 720
cgtgatgctg cgggataact cgggggaccc ggccgacccg cacaaggtgt acgcgctcag 780
ccgggagctg tgctggcgag aaggcccagg cacggaccag actgaggcag aggcccccgc 840
agctgtccca ccaccacagg gtgggccccc agggccattc ctggcacaca cacatgctgg 900
actccaagcc ccaggccccc tccctgcccc agctggtgac aagggggacc tcctgctcca 960
ggcagtgcaa cagagctgcc tggcagacca tctgctgaca gcgtcatggg gggcagatcc 1020
agtcccaacc aaggctcctg gagagggaca agaagggctt cccctgactg gggcctgtgc 1080
tggaggccca gggctccctg ctggggagct gtacgggtgg gcagtagaga cgacccccag 1140
ccccgggccc cagcccgcgg cactaacgac aggcgaggcc gcggccccag agtccccgca 1200
ccaggcagag ccgtacctgt caccctcccc aagcgcctgc accgcggtgc aagagcccag 1260
cccaggggcg ctggacgtga ccatcatgta caagggccgc acggtgctgc agaaggtggt 1320
gggacacccg agctgcacgt tcctatacgg ccccccagac ccagctgtcc gggccacaga 1380
cccccagcag gtagcattcc ccagccctgc cgagctcccg gaccagaagc agctgcgcta 1440
cacggaggaa ctgctgcggc acgtggcccc tgggttgcac ctggagcttc gggggccaca 1500
gctgtgggcc cggcgcatgg gcaagtgcaa ggtgtactgg gaggtgggcg gacccccagg 1560
ctccgccagc ccctccaccc cagcctgcct gctgcctcgg aactgtgaca cccccatctt 1620
cgacttcaga gtcttcttcc aagagctggt ggaattccgg gcacggcagc gccgtggctc 1680
cccacgctat accatctacc tgggcttcgg gcaggacctg tcagctggga ggcccaagga 1740
gaagagcctg gtcctggtga agctggaacc ctggctgtgc cgagtgcacc tagagggcac 1800
gcagcgtgag ggtgtgtctt ccctggatag cagcagcctc agcctctgcc tgtccagcgc 1860
caacagcctc tatgacgaca tcgagtgctt ccttatggag ctggagcagc ccgcctagaa 1920
cccagtctaa tgagaactcc agaaagctgg agcagcccac ctagagctgg ccgcggccgc 1980
ccagtctaat aaaaagaact ccagaaca 2008
<210> 32
<211> 1876
<212> DNA
<213> 小家鼠
<400> 32
tgagataaaa cccgtcccgg cggctccggt accagggtcc agcctgtgac agcccatcca 60
ggctcggacg ctggattaac acctgtgaca tcacgtgtgc gctcccgcta catctgtagt 120
cacatctaca gccaccttgg cagaggaatc tacactgagt tctgaaccta ggtgaccaca 180
agttctcaaa cctcatctgt gaccctcaac accctaatac ctgggtcaca cttgtgaaac 240
tgaaattcct acctgttacc aacacttgta acgtttaaaa cacatttgtg aaacttggtc 300
acactatctg tggctacaac ctaaaaccat agaggcaccc aaggggcctt atttgcaata 360
gctgactgct ccagtgacta caaggcatca cagagtagta gcatctactt tgattctccc 420
agactgcctg tgtagacgga gcaatggctg aagtgagggg ggtccagcga gtgctgtttg 480
gagactggct attgggggag gtcagcagcg gccagtacga ggggctgcag tggctgaacg 540
aggctcgcac agtcttccgc gtaccctgga agcatttcgg tcgtagggat ctggatgaag 600
aagatgcaca gatcttcaag gcctgggctg tggcccgagg gaggtggcca cctagtggag 660
ttaacctgcc acccccagag gctgaggctg ctgagcgaag agagcgaaga ggctggaaga 720
ccaacttccg ctgtgcactc cacagcacag ggcgttttat cttgcgccaa gacaattcag 780
gggatccagt tgatccgcat aaggtgtacg aacttagccg ggagcttgga tctactgtgg 840
gcccagccac ggaaaatagg gaagaagtga gcctcagcaa tgctctgccc acacagggtg 900
tgtccccagg atcatttctg gcaagagaaa atgctgggct ccaaacccca agccctctgc 960
tttctagtga tgccggggac ctcttgcttc aggttctgca gtacagccac atactggaat 1020
ccgagtctgg ggcagacccc gtcccaccac aggctcctgg ccaggagcaa gaccgtgttt 1080
acgaggaacc ctatgcagca tggcaggtgg aagctgtccc cagtcccagg cctcaacagc 1140
cagctctcac cgagcgcagc cttgggttcc tggatgtgac catcatgtac aagggccgca 1200
cagtgctaca ggcagtggtg gggcacccca gatgcgtgtt cctgtacagc cccatggccc 1260
cagcagtaag aacttcagag ccccagccgg tgatctttcc cagtcctgct gagctcccag 1320
atcagaagca gctgcactac acagagacgc ttctccagca tgtgtctccc ggccttcagc 1380
tggagcttcg aggaccgtca ctgtgggccc tgcgtatggg caagtgcaag gtgtactggg 1440
aggtaggcag ccctatgggc actaccggcc cctccacccc accccagctg ctggagcgca 1500
accgccacac ccccatcttc gacttcagca ctttcttccg agaactggag gagtttcggg 1560
ctcggaggcg gcaagggtca ccacactaca ccatctacct gggttttggg caagacttgt 1620
cagcagggag gcccaaggag aagaccctga tcctggtgaa gctggagcca tgggtatgca 1680
aggcatacct ggagggcgtg cagcgtgagg gtgtgtcctc cctggacagc agcagtctcg 1740
gcttgtgctt gtctagcacc aacagtctct acgaagacat cgaacacttc ctcatggacc 1800
tgggtcagtg gccttgactc agaatcccaa ctcccaataa atagttcaaa atcagtggaa 1860
aaaaaaaaaa aaaaaa 1876
<210> 33
<211> 7281
<212> DNA
<213> 智人
<400> 33
gcagtcacag acacttgagc acacgcgtac acccagacat cttcgggctg ctattggatt 60
gactttgaag gttctgtgtg ggtcgccgtg gctgcatgtt tgaatcaggt ggagaagcac 120
ttcaacgctg gacgaagtaa agattattgt tgttattttt tttttctctc tctctctctc 180
ttaagaaagg aaaatatccc aaggactaat ctgatcgggt cttccttcat caggaacgaa 240
tgcaggaatt tgggaactga gctgtgcaag tgctgaagaa ggagatttgt ttggaggaaa 300
caggaaagag aaagaaaagg aaggaaaaaa tacataattt cagggacgag agagagaaga 360
aaaacgggga ctatggggag aaaaaagatt cagattacga ggattatgga tgaacgtaac 420
agacaggtga catttacaaa gaggaaattt gggttgatga agaaggctta tgagctgagc 480
gtgctgtgtg actgtgagat tgcgctgatc atcttcaaca gcaccaacaa gctgttccag 540
tatgccagca ccgacatgga caaagtgctt ctcaagtaca cggagtacaa cgagccgcat 600
gagagccgga caaactcaga catcgtggag acgttgagaa agaagggcct taatggctgt 660
gacagcccag accccgatgc ggacgattcc gtaggtcaca gccctgagtc tgaggacaag 720
tacaggaaaa ttaacgaaga tattgatcta atgatcagca ggcaaagatt gtgtgctgtt 780
ccacctccca acttcgagat gccagtctcc atcccagtgt ccagccacaa cagtttggtg 840
tacagcaacc ctgtcagctc actgggaaac cccaacctat tgccactggc tcacccttct 900
ctgcagagga atagtatgtc tcctggtgta acacatcgac ctccaagtgc aggtaacaca 960
ggtggtctga tgggtggaga cctcacgtct ggtgcaggca ccagtgcagg gaacgggtat 1020
ggcaatcccc gaaactcacc aggtctgctg gtctcacctg gtaacttgaa caagaatatg 1080
caagcaaaat ctcctccccc aatgaattta ggaatgaata accgtaaacc agatctccga 1140
gttcttattc caccaggcag caagaatacg atgccatcag tgtctgagga tgtcgacctg 1200
cttttgaatc aaaggataaa taactcccag tcggctcagt cattggctac cccagtggtt 1260
tccgtagcaa ctcctacttt accaggacaa ggaatgggag gatatccatc agccatttca 1320
acaacatatg gtaccgagta ctctctgagt agtgcagacc tgtcatctct gtctgggttt 1380
aacaccgcca gcgctcttca ccttggttca gtaactggct ggcaacagca acacctacat 1440
aacatgccac catctgccct cagtcagttg ggagcttgca ctagcactca tttatctcag 1500
agttcaaatc tctccctgcc ttctactcaa agcctcaaca tcaagtcaga acctgtttct 1560
cctcctagag accgtaccac caccccttcg agatacccac aacacacgcg ccacgaggcg 1620
gggagatctc ctgttgacag cttgagcagc tgtagcagtt cgtacgacgg gagcgaccga 1680
gaggatcacc ggaacgaatt ccactccccc attggactca ccagaccttc gccggacgaa 1740
agggaaagtc cctcagtcaa gcgcatgcga ctttctgaag gatgggcaac atgatcagat 1800
tattacttac tagttttttt ttttttcttg cagtgtgtgt gtgtgctata ccttaatggg 1860
gaaggggggt cgatatgcat tatatgtgcc gtgtgtggaa aaaaaaaaag tcaggtactc 1920
tgttttgtaa aagtactttt aaattgcctc agtgatacag tataaagata aacagaaatg 1980
ctgagataag cttagcactt gagttgtaca acagaacact tgtacaaaat agattttaag 2040
gctaacttct tttcactgtt gtgctccttt gcaaaatgta tgttacaata gatagtgtca 2100
tgttgcaggt tcaacgttat ttacatgtaa atagacaaaa ggaaacattt gccaaaagcg 2160
gcagatcttt actgaaagag agagcagctg ttatgcaaca tatagaaaaa tgtatagatg 2220
cttggacaga cccggtaatg ggtggccatt ggtaaatgtt aggaacacac caggtcacct 2280
gacatcccaa gaatgctcac aaacctgcag gcatatcatt ggcgtatggc actcattaaa 2340
aaggatcaga gaccattaaa agaggaccat acctattaaa aaaaaatgtg gagttggagg 2400
gctaacatat ttaattaaat aaataaataa atctgggtct gcatctctta ttaaataaaa 2460
atataaaaat atgtacatta cattttgctt attttcatat aaaaggtaag acagagtttg 2520
caaagcattt gtggcttttt gtagtttact taagccaaaa tgtgtttttt tccccttgat 2580
agcttcgcta atattttaaa cagtcctgta aaaaaccaaa aaggactttt tgtatagaaa 2640
gcactaccct aagccatgaa gaactccatg ctttgctaac caagataact gttttctctt 2700
tgtagaagtt ttgtttttga aatgtgtatt tctaattata taaaatatta agaatctttt 2760
aaaaaaatct gtgaaattaa catgcttgtg tatagctttc taatatatat aatattatgg 2820
taatagcaga agttttgtta tcttaatagc gggagggggg tatatttgtg cagttgcaca 2880
tttgagtaac tattttcttt ctgttttctt ttactctgct tacattttat aagtttaagg 2940
tcagctgtca aaaggataac ctgtggggtt agaacatatc acattgcaac accctaaatt 3000
gtttttaata cattagcaat ctattgggtc aactgacatc cattgtatat actagtttct 3060
ttcatgctat ttttattttg ttttttgcat ttttatcaaa tgcagggccc ctttctgatc 3120
tcaccatttc accatgcatc ttggaattca gtaagtgcat atcctaactt gcccatattc 3180
taaatcatct ggttggtttt cagcctagaa tttgatacgc tttttagaaa tatgcccaga 3240
atagaaaagc tatgttgggg cacatgtcct gcaaatatgg ccctagaaac aagtgatatg 3300
gaatttactt ggtgaataag ttataaattc ccacagaaga aaaatgtgaa agactgggtg 3360
ctagacaaga aggaagcagg taaagggata gttgctttgt catccgtttt taattatttt 3420
aactgaccct tgacaatctt gtcagcaata taggactgtt gaacaatccc ggtgtgtcag 3480
gacccccaaa tgtcacttct gcataaagca tgtatgtcat ctattttttc ttcaataaag 3540
agatttaata gccatttcaa gaaatcccat aaagaacctc tctatgtccc tttttttaat 3600
ttaaaaaaaa tgactcttgt ctaatattcg tctataaggg attaattttc agacccttta 3660
ataagtgagt gccataagaa agtcaatata tattgtttaa aagatatttc agtctaggaa 3720
agattttcct tctcttggaa tgtgaagatc tgtcgattca tctccaatca tatgcattga 3780
catacacagc aaagaagata taggcagtaa tatcaacact gctatatcat gtgtaggaca 3840
tttcttatcc attttttctc ttttacttgc atagttgcta tgtgtttctc attgtaaaag 3900
gctgccgctg ggtggcagaa gccaagagac cttattaact aggctatatt tttcttaact 3960
tgatctgaaa tccacaatta gaccacaatg cacctttggt tgtatccata aaggatgcta 4020
gcctgccttg tactaatgtt ttatatatta aaaaaaaaaa atctatcaac catttcatat 4080
atatcccact actcaaggta tccatggaac atgaaagaat aacatttatg cagaggaaaa 4140
acaaaaacat ccctgaaaat atacacactc atacacacac acgcacaggg gaataaaata 4200
agaaaatcat tttcctcacc atagacttga tcccatcctt acaacccatc cttctaactt 4260
gatgtgtata aaatatgcaa acatttcaca aatgttcttt gtcatttcaa aatactttag 4320
tatatcaata tcagtagata ccagtgggtg ggaaagggtc attacatgaa aatatgaaga 4380
aatagccata ttagtttttt aacctgcaat ttgcctcagc aacaaagaaa aagtgaattt 4440
ttaatgctga agataaagta agctaaagta ccagcagaag ccttggctat ttatagcagt 4500
tctgacaata gttttataag aacatgaaga gaacagaatc acttgaaaat ggatgccagt 4560
catctcttgt tcccactact gaattcttat aaagtggtgg caagataggg aagggataat 4620
ctgagaattt ttaaaagatg atttaatgag aagaagcaca attttgattt tgatgagtca 4680
ctttctgtaa acaatcttgg tctatcttta cccttatacc ttatctgtaa tttaccattt 4740
attgtatttg caaagctagt atggttttta atcacagtaa atcctttgta ttccagactt 4800
tagggcagag ccctgaggga gtattatttt acataacccg tcctagagta acattttagg 4860
caacattctt cattgcaagt aaaagatcca taagtggcat tttacacggc tgcgagtatt 4920
gttatatcta atcctatttt aaaagatttt tggtaatatg aagcttgaat actggtaaca 4980
gtgatgcaat atacgcaagc tgcacaacct gtatattgta tgcattgctg cgtggaggct 5040
gtttatttca acctttttaa aaattgtgtt ttttagtaaa atggcttatt ttttcccaaa 5100
ggtggaattt agcattttgt aatgatgaat ataaaaatac ctgtcatccc cagatcattt 5160
aaaagttaac taaagtgaga atgaaaaaac aaaattccaa gacacttttt aaaagaatgt 5220
ctgccctcac acacttttat ggatttgttt ttcttacata cccatctttt aacttagaga 5280
tagcattttt tgccctcttt attttgttgt ttgtttctcc agagagtaaa cgctttgtag 5340
ttctttcttt aaaaaacatt ttttttaaag aagaagaagc cacttgaacc ctcaataaag 5400
gctgttgcct aagcatggca tacttcatct gttctcattt gtgccatctg ccgtgatgtc 5460
gtcactttta tggcgttaat ttcctgccac tacagatctt ttgaagattg ctggaatact 5520
ggtgtctgtt agaatgcttc agactacaga tgtaattaaa ggcttttctt aatatgtttt 5580
aaccaaagat gtggagcaat ccaagccaca tatcttctac atcaaatttt tccattttgg 5640
ttattttcat aatctggtat tgcattttgc cttccctgtt catacctcaa attgattcat 5700
acctcagttt aattcagaga ggtcagttaa gtgacggatt ctgttgtggt ttgaatgcag 5760
taccagtgtt ctcttcgagc aaagtagacc tgggtcactg taggcatagg acttggattg 5820
cttcagatgg tttgctgtat catttttctt ctttttcttt tcctggggac ttgtttccat 5880
taaatgagag taattaaaat cgcttgtaaa tgagggcata caagcatttg caacaaatat 5940
tcaaatagag gctcacagcg gcataagctg gactttgtcg ccactagatg acaagatgtt 6000
ataactaagt taaaccacat ctgtgtatct caagggactt aattcagctg tctgtagtga 6060
ataaaagtgg gaaattttca aaagtttctc ctgctggaaa taaggtataa tttgtatttt 6120
gcagacaatt cagtaaagtt actggctttc ttagtgatgc agtgtccgtg gtgcattttt 6180
ttaaattaat gttttgctgt ttaaatttat tcaattttat tgtgtttttt aaaaagcagc 6240
ttatgccaca agcacaaatg agctttctca gttttcaact caaaatatta tatgaaaaga 6300
tggatatgtg tgtctgtgtg ggaggggtgt gaattggatg acggttctta gggtattaca 6360
gaattcagcc agtggtggaa gtctaaggtt cttattgaat ggttcaactt ctttatcaaa 6420
gaagttccat gaagatcttt gataacctgt ttaaatgtac agaatttttc aaaagccact 6480
gtgaaaagca gtaccataag ttatttttta actaaaatct gtagaaagtg tttccaaaag 6540
agttcctttt ttcttcttcg aagtaatttc taaaagttga aaacataggc ttataaatct 6600
gaataaatta gtgaattcat acattttaga gactatcaaa tatatccatt attaacattc 6660
aataataatc tctaaagggg aatgtcctta aaaagattga tagaaagatt aatttaaaaa 6720
ctgaaaagga aaacaagaca ccaccagtta gccagctgga gaacttggac ttttgcatta 6780
gtagtgatat ctgctccaaa aagaatgcag ttcgaggaaa tgttgcatgt ggcttcaaaa 6840
tagcagtgct ttctgctttg ttctcttgta ttcattttca gcaaacatgt attaagcaat 6900
tattatatgt aactcatgtg gtgattccag gatgaatgaa gttgtagccc tttctcttag 6960
gaaacttata aactaatagg agataaaagg cattctcagg gaagtctaca aagtgctatg 7020
agggagccac tttggccatc ctggggcaga gcagaccaga ggctcagagc atggacactt 7080
cctcatccac ccagcagaag cctttcactt gattttgaag gtgggcagga ttgagaaagg 7140
cccagaaggg gatgagttca aagctgtttg tgggcatgtg acccctgcag tcacatatgg 7200
ccctagcttg tgtttcgttt agtgttctgc tatcattatc ctgataatat cctgataata 7260
aaattatcct taataatttt a 7281
<210> 34
<211> 6451
<212> DNA
<213> 小家鼠
<400> 34
gagcagttct gtgttctttt gccagcactg acaaaggtct ggttgtcaat gataccttta 60
cagctaaatt tactccagag tgacatgaac aggtgcaccc tggcctgcca gacacttgtg 120
cagagggatc acgcatctca ccgcttgacg atcaaggggg caaagcttcg gtgttcatag 180
aaaaggagag gaggcgagcg cagcccaaac tggggggttt ctcttcaaag ccagctggtc 240
tggctttatt ctacaggaat ttttttacct gtcagagttt ggacaacaaa gccctcagca 300
ggtgctgacg ggaacaactt cctggagaag cagaaaggca ctggtgccaa caaaagcatt 360
gaaaactgtg aagtaacctc tggagagatg aagtgaagcg tggaaggcca atggctgtgg 420
cagtgaagaa gtgcagaggg aacgaatgca gggatttggg aactgagctg tgcgcgtgct 480
gaagaaggaa acgtgtttga aggaaacagg aaagagaaag aaaaggaagg aaaaaataca 540
taatttcagg gacgagagag agaagaaaca cggggactat ggggagaaaa aagattcaga 600
ttacgaggat aatggatgag cgtaacagac aggtgacttt tacgaagagg aaatttggat 660
tgatgaagaa ggcttatgag ctgagcgtgc tgtgcgactg tgagattgca ctgatcatct 720
tcaacagcac caacaagctg ttccagtacg ccagcactga catggataag gtgttgctca 780
agtacaccga gtacaacgag ccgcacgaga gccggacaaa ctcagacatt gtggagacat 840
tgagaaagaa gggcctcaat ggctgtgaca gcccagatcc cgatgcagac gattcagtag 900
gtcacagccc tgagtctgag gacaagtaca ggaaaattaa cgaagatatt gatctaatga 960
tcagcaggca aagattgtgt gctgttccac ctcccagctt tgagatgcca gttaccatcc 1020
cagtgtccag ccataacagt ttggtgtaca gcaatcctgt cagcacactg ggaaacccca 1080
atcttctgcc actggcccac ccgtctctgc agaggaatag tatgtctcct ggtgtaacac 1140
atagacctcc aagtgcaggt aacacaggcg gtctgatggg cggagatctg acatccggtg 1200
caggcaccag cgcagggaat ggatacggca acccccggaa ctcaccaggc ctgctggtct 1260
cacctggtaa cctgaacaag aatatacaag ccaaatctcc tccccctatg aatctaggaa 1320
tgaataatcg taagccagat ctccgcgttc ttatcccacc tggcagcaag aacacgatgc 1380
catcagtgtc tgaggatgtg gatctgctgt tgaatcaaag gataaataac tcccagtcgg 1440
ctcagtcatt ggctaccccg gtggtttccg tagcaactcc tactttacca ggacaaggaa 1500
tgggaggata tccatcagcc atttcaacaa catatggtac tgagtactct ctgagtagcg 1560
cagatctgtc atctctgtct ggcttcaaca ctgccagtgc gctccacctc ggctctgtaa 1620
ctggctggca gcagcagcac ctacataaca tgccgccatc tgccctcagt cagttgggag 1680
cttgcactag cactcattta tctcagagtt caaatctctc cctgccttct actcaaagcc 1740
tcagcatcaa gtcagaacct gtttctcctc ctagagaccg taccaccacc ccttcgagat 1800
acccacaaca caccacgcgc cacgaggcgg ggaggtctcc tgttgacagc ttgagcagct 1860
gtagcagttc ctacgatggg agcgaccgag aggatcaccg gaacgaattc cactccccca 1920
ttggactcac cagaccttcg ccggacgaaa gggaaagtcc ttcagtcaag cgcatgcgac 1980
tctctgaagg atgggcaaca tgatcacatt attacttaat agtttttttt tttcttgcag 2040
tgtgtgtgtg tgctatacct taatggggaa gggggggtcg atatgcatta tatgtgccgt 2100
gtgtggaaaa aaaaaaaaaa gtcaggtact ctgttttgta aaagtacttt taaattgcct 2160
cagtgataca gtataaagat aaacagaaat gctgagatac gcttagcact tgagttgtac 2220
aacagaacac ttgtacaaaa tagattttaa ggctaacttc ttttcactgt tgtgaccctt 2280
tgcaaaatgt atgttacaat agatagtgtc atgttgcagg ttcaacgtta tttacatgta 2340
aatagacaaa aggaaacatt tgccaaaagc ggcagatctt tactgaaaga gagagcagct 2400
gttatgcaac atatagaaaa atgtatagag gtttggacag acccggcaag tggtgactac 2460
cggtaattgt aggaacacgc ctgtcaccta acatccaagc acgctcacaa acctgcaggc 2520
atatcattgg cgtatggcac tcattcaaaa ggatcagaaa ccattcagag aggaccatac 2580
ctaccttaaa agaaaagaga agaaaggaaa ggaaaggaaa gggaaaaaaa agtgtggcgt 2640
ttgagagcta acatatttaa ttaaataaat aaatctgggt ctgcatctct tattaaataa 2700
aaatataaaa atatgtacat tacattttgc ttattttcat ataaaaggta agaaagagtt 2760
tgcaaagcat ttgtggcttt ttgtagttta cttaagccaa aatgtgtttt tccctcaata 2820
gcttcgctaa tattttaaac agtcctgtaa aaacccacca aggacttttt gtatagaaag 2880
cactacccta agccatgagg atctccatgc tttgctaacc aagataactg ttttctcttt 2940
gtagaagttt tgtttttgaa atgtgtattt ctaattatat aaaatattaa gaatctttta 3000
aaaatctgtg aaattaacat gcttgtgtat agctttctaa tatatataat attatggtaa 3060
tggcagaagt tttgttttct taatagcggg aggggggtat atttgtgcag ttgcacattt 3120
gagtaactat tttctttctg atttctttta ctctgcatac attttataag ttcaaggtca 3180
gctgtcaaaa ggataagctg tggggttaga acatattaca ttgcaacatc ctaaattgtt 3240
tttaaaacgt cagcaaacta ttgggtcaac tgacatccat tgtatatact aattggtttc 3300
tttcaaacta tttttttttt tggtttggtt ttgaattgtt ggtttctttt cattttatca 3360
aaagcagggc ccctttcaga tctctcttca tttcaccata catcttggaa ttctgtaagt 3420
ttgtatccta acttgcccat attctaaatt tacatagttt attttcagcc ttgagttgga 3480
tgttttttag aaatatgccc agagtaagaa gctgtgttgg agcctaagtc ctgcaagctg 3540
ggtcctgggg gcgaccgacc tgctttactt gatggataag ttacagagtt ctggaggaga 3600
acaaggtgaa agcctgggtg ctggagagga aggaaacagt taaagggtag ttacttggta 3660
tccaccttca tgattttaac tgacccataa caatgttgtc agcagtatag gactgttgaa 3720
cagcctggtg tgtcaggacc cccaaatgtc acttctgcct aaagcatgta tgtcacctat 3780
ttttttcttc aataaagaaa tttaacagcc atttcaagaa atcccacttt aaaaaaaaaa 3840
aaaaacaaac ctttctctat gtcccccccc ctttttttta attttcaaga taatttaact 3900
cttgtctaat attcttgtgt aagggattaa ttttcagacc cctttaaaag tgagtgccat 3960
aaagagtcaa tatatagtgt tgaagtggta tttcaggcta ggaattattc ccttctcttg 4020
gaatgtgaag atctgtcgat tcatcctgtc attaatcctg acatacagaa caaagaatgc 4080
agtaacatta gccctgccag gtcacgtgta ggacgtgctt atccagtttt ttcccccttt 4140
acctgcatag ttgctacata catgtttctc actgtaaaag gctgccgctg ggtggcagaa 4200
gccaaaagac cttattaacg aggctatatt tttcttaact tgatctgcaa tccagaatta 4260
gaccacaatg cacctttggt ggtatccata taggatgcta gcctgccttg tagtaatgtt 4320
ttatatgtta aaaacaaaat aaagacatca accatttcac atatattcta ctactaaagg 4380
tatcaatgga acatgaagac gagtatttag gcagaagcaa aacaggaaac catccttaca 4440
aacatgctta cctgcacatc tgtttgcatg gtcatgtgta cattcaaaca tgcacataaa 4500
gtgaacaaga aagtcagcca ttatttcacg ccagacttga ttccatcctg agaattcatg 4560
tttataatta aatgtgtgtt aaatatgcaa gcatatcaca aatgttcctt gtcctttcaa 4620
agtgcatttg ttcatcaaga tcaatagaat cttaccagtg ggtaggaaag gatcatataa 4680
aatatgaaga aatagccata ttaaattttt tgctgtcatt tgcctccgca acaaagcgag 4740
tgtaagtgtc taatgctgaa gctagagtga actcatgtgc cagcagaggc ctcctctctt 4800
tatagcaatt ctgacaatag gtttgtttgt ttgtttgttt gtttttacaa actcaagaaa 4860
aacagactca cttgaaaaaa tggatgccag tcacctggtt cccactactg tcgtagcaga 4920
tagcgaaggg acaatctgag acttgtagag atgatttaat gagaagcaca atttttattg 4980
tgaccagtca cgttctatca ccaggcactg tcttgtcttt gcccttgcct tttctgtaac 5040
tcaccattta ttgtatttac aaatctagta agggttttga tcacaccaag ttctttgtat 5100
tgagaagtct agggcagagc tctgggggat tgttatttta cattacctgg cctagagtag 5160
catattagac aacagtcatc attgcaagta ggaggaccgt aaatggcatt ttacatgact 5220
gcaagtattg ttataccgaa tcctatttta aaagagtttt agtaacggtg agctgagaaa 5280
ttctggtcat ggtgagcagc aggcgcaagc catgcagcct gtggactgtg cgcattgata 5340
tgtggaggct gttgatttca acctttttta aacttgtgtt ttttagtaaa attgcttatt 5400
tttttcccaa aggtggaatt taatgttttg tagtgatgaa tatgaaaatg cctgtcatct 5460
ttagatcatt gaaaggttaa ctaacatgag aatttcagag caaattccaa tactctttta 5520
aaaagcgtgt ctgccctctc ttacttctat gtatttgttt atcgacacac tcaccctttc 5580
tgagatagca ttttgctccc ttgatccccc cctttttttg tcccttcgaa gagtaaatgc 5640
tttgtatttc tttctttaaa aaatttactt taaagaagaa gccacttgaa ccttcaataa 5700
aggctgttgc ctaaacatgg cgtacttcat ctgttcccgc ctctgccatc tgctacggtg 5760
tcgtcagttg tatggcatta atttcctgcc actagagata ttttgaagat tgcttgaatg 5820
ctggtgtctg ttagaatgct tctgactaca gatgtaatta aaggcttttc ttactatgtt 5880
ttaaccaaag atgtggagca atccaagccg catatctact gcattaaatt tgtccatttg 5940
gttattcata atcgggtatt gcattttgcc ttccctgtcc atacctcaaa ttgattgata 6000
cctcagttta attcagagag gttcgctaag tgttggattc tagttgtggt ttgaatgcag 6060
cagtgtactc ttgaagtaag caggcaaggg tcactgcagg catgaagctt ggattgcttc 6120
agatggtttg ccgtatcgtt tttcttcctt ttccttttct ggggacttgt ttccattcaa 6180
tgacaattaa aatagcttgt aaatgagggc atacaagcat ttgcaacaag tattcaaata 6240
gaggctcaca gcggcataag ctggactttg tcgccactag atgacaagat ggtataccta 6300
agctaaccac acgtgtgtat ctcaagggac ttaaattcag ctgtctgtag tgaattcaag 6360
tgggaaattt tcaaaagttt ctcctgctgg aaataaggta taatttgtat tttgcagaca 6420
attcagtaaa gttactggct ttcttagtga t 6451
<210> 35
<211> 3684
<212> DNA
<213> 智人
<400> 35
acactttaat atcaacctgt ttcctcctcc tccttctcct cctcctccgt gacctcctcc 60
tcctctttct cctgagaaac ttcgccccag cggtgcggag cgccgctgcg cagccgggga 120
gggacgcagg caggcggcgg gcagcgggag gcggcagccc ggtgcggtcc ccgcggctct 180
cggcggagcc ccgcgcccgc cgcgccatgg cccgaagacc ccggcacagc atatatagca 240
gtgacgagga tgatgaggac tttgagatgt gtgaccatga ctatgatggg ctgcttccca 300
agtctggaaa gcgtcacttg gggaaaacaa ggtggacccg ggaagaggat gaaaaactga 360
agaagctggt ggaacagaat ggaacagatg actggaaagt tattgccaat tatctcccga 420
atcgaacaga tgtgcagtgc cagcaccgat ggcagaaagt actaaaccct gagctcatca 480
agggtccttg gaccaaagaa gaagatcaga gagtgataga gcttgtacag aaatacggtc 540
cgaaacgttg gtctgttatt gccaagcact taaaggggag aattggaaaa caatgtaggg 600
agaggtggca taaccacttg aatccagaag ttaagaaaac ctcctggaca gaagaggaag 660
acagaattat ttaccaggca cacaagagac tggggaacag atgggcagaa atcgcaaagc 720
tactgcctgg acgaactgat aatgctatca agaaccactg gaattctaca atgcgtcgga 780
aggtcgaaca ggaaggttat ctgcaggagt cttcaaaagc cagccagcca gcagtggcca 840
caagcttcca gaagaacagt catttgatgg gttttgctca ggctccgcct acagctcaac 900
tccctgccac tggccagccc actgttaaca acgactattc ctattaccac atttctgaag 960
cacaaaatgt ctccagtcat gttccatacc ctgtagcgtt acatgtaaat atagtcaatg 1020
tccctcagcc agctgccgca gccattcaga gacactataa tgatgaagac cctgagaagg 1080
aaaagcgaat aaaggaatta gaattgctcc taatgtcaac cgagaatgag ctaaaaggac 1140
agcaggtgct accaacacag aaccacacat gcagctaccc cgggtggcac agcaccacca 1200
ttgccgacca caccagacct catggagaca gtgcacctgt ttcctgtttg ggagaacacc 1260
actccactcc atctctgcca gcggatcctg gctccctacc tgaagaaagc gcctcgccag 1320
caaggtgcat gatcgtccac cagggcacca ttctggataa tgttaagaac ctcttagaat 1380
ttgcagaaac actccaattt atagattctg attcttcatc atggtgtgat ctcagcagtt 1440
ttgaattctt tgaagaagca gatttttcac ctagccaaca tcacacaggc aaagccctac 1500
agcttcagca aagagagggc aatgggacta aacctgcagg agaacctagc ccaagggtga 1560
acaaacgtat gttgagtgag agttcacttg acccacccaa ggtcttacct cctgcaaggc 1620
acagcacaat tccactggtc atccttcgaa aaaaacgggg ccaggccagc cccttagcca 1680
ctggagactg tagctccttc atatttgctg acgtcagcag ttcaactccc aagcgttccc 1740
ctgtcaaaag cctacccttc tctccctcgc agttcttaaa cacttccagt aaccatgaaa 1800
actcagactt ggaaatgcct tctttaactt ccacccccct cattggtcac aaattgactg 1860
ttacaacacc atttcataga gaccagactg tgaaaactca aaaggaaaat actgttttta 1920
gaaccccagc tatcaaaagg tcaatcttag aaagctctcc aagaactcct acaccattca 1980
aacatgcact tgcagctcaa gaaattaaat acggtcccct gaagatgcta cctcagacac 2040
cctctcatct agtagaagat ctgcaggatg tgatcaaaca ggaatctgat gaatctggaa 2100
ttgttgctga gtttcaagaa aatggaccac ccttactgaa gaaaatcaaa caagaggtgg 2160
aatctccaac tgataaatca ggaaacttct tctgctcaca ccactgggaa ggggacagtc 2220
tgaataccca actgttcacg cagacctcgc ctgtggcaga tgcaccgaat attcttacaa 2280
gctccgtttt aatggcacca gcatcagaag atgaagacaa tgttctcaaa gcatttacag 2340
tacctaaaaa caggtccctg gcgagcccct tgcagccttg tagcagtacc tgggaacctg 2400
catcctgtgg aaagatggag gagcagatga catcttccag tcaagctcgt aaatacgtga 2460
atgcattctc agcccggacg ctggtcatgt gagacatttc cagaaaagca ttatggtttt 2520
cagaacactt caagttgact tgggatatat cattcctcaa catgaaactt ttcatgaatg 2580
ggagaagaac ctatttttgt tgtggtacaa cagttgagag cagcaccaag tgcatttagt 2640
tgaatgaagt cttcttggat ttcacccaac taaaaggatt tttaaaaata aataacagtc 2700
ttacctaaat tattaggtaa tgaattgtag ccagttgtta atatcttaat gcagattttt 2760
ttaaaaaaaa cataaaatga tttatctgta ttttaaagga tccaacagat cagtattttt 2820
tcctgtgatg ggttttttga aatttgacac attaaaaggt actccagtat ttcacttttc 2880
tcgatcacta aacatatgca tatattttta aaaatcagta aaagcattac tctaagtgta 2940
gacttaatac catgtgacat ttaatccaga ttgtaaatgc tcatttatgg ttaatgacat 3000
tgaaggtaca tttattgtac caaaccattt tatgagtttt ctgttagctt gctttaaaaa 3060
ttattactgt aagaaatagt tttataaaaa attatatttt tattcagtaa tttaattttg 3120
taaatgccaa atgaaaaacg ttttttgctg ctatggtctt agcctgtaga catgctgcta 3180
gtatcagagg ggcagtagag cttggacaga aagaaaagaa acttggtgtt aggtaattga 3240
ctatgcacta gtatttcaga ctttttaatt ttatatatat atacattttt tttccttctg 3300
caatacattt gaaaacttgt ttgggagact ctgcattttt tattgtggtt tttttgttat 3360
tgttggttta tacaagcatg cgttgcactt cttttttggg agatgtgtgt tgttgatgtt 3420
ctatgttttg ttttgagtgt agcctgactg ttttataatt tgggagttct gcatttgatc 3480
cgcatcccct gtggtttcta agtgtatggt ctcagaactg ttgcatggat cctgtgtttg 3540
caactgggga gacagaaact gtggttgata gccagtcact gccttaagaa catttgatgc 3600
aagatggcca gcactgaact tttgagatat gacggtgtac ttactgcctt gtagcaaaat 3660
aaagatgtgc ccttatttta ccta 3684
<210> 36
<211> 3777
<212> DNA
<213> 小家鼠
<400> 36
gggagtgtcc aaacctcttt gtttgatggc atctgtttac agagttacac tttaatatca 60
acctgtttcc tcctcctcct tctcctcctt ctcctcctcc tcctcggtga cctccttctc 120
ctcccctttc tccggagaaa cttcgccccg gcggtgcgga gcgccgctgc gcagccgggg 180
gaggacgcag gcaaggcgga gggcagcggg aggcggcaac cggtgcggtc cccggggctc 240
ttggcggagc cccggcccgc ctcgccatgg cccggagacc ccgacacagc atctacagta 300
gcgatgaaga tgatgaagac attgagatgt gtgaccatga ctacgatggg ctgctgccca 360
aatctggaaa gcgtcacttg gggaaaacta ggtggacaag ggaagaggat gagaagctga 420
agaagctggt ggaacagaac ggaacagacg actggaaagt cattgccaat tatctgccca 480
accggacaga tgtgcagtgc caacaccggt ggcagaaagt gctgaaccct gaactcatca 540
aaggtccctg gaccaaagaa gaagatcaga gagtcataga gcttgtccag aaatatggtc 600
cgaagcgttg gtctgttatt gccaagcact taaaagggag aattggaaag cagtgtcggg 660
agaggtggca caaccatttg aatccagaag ttaagaaaac ctcctggaca gaagaggagg 720
acagaatcat ttaccaggca cacaagcgtc tggggaacag atgggcagag atcgcaaagc 780
tgctgcccgg acggactgat aatgctatca agaaccactg gaattccacc atgcgtcgca 840
aggtggaaca ggaaggctac ctgcaggagc cttccaaagc cagccagacg ccagtggcca 900
cgagcttcca gaagaacaat catttgatgg ggtttgggca tgcctcacct ccatctcagc 960
tctctccaag tggccagtcc tccgtcaaca gcgaatatcc ctattaccac atcgccgaag 1020
cacaaaacat ctccagtcac gttccctatc ctgtcgcatt gcatgttaat atagtcaacg 1080
tccctcagcc ggctgcggca gccatccaga gacactataa cgacgaagac cctgagaagg 1140
aaaagcgaat aaaggagctg gagttgctcc tgatgtcaac agagaacgag ctgaagggac 1200
agcaggcatt accaacacag aaccacactt gcagctaccc cgggtggcac agcacctcca 1260
ttgtggacca gaccagacct catggggata gtgcacctgt ttcctgtttg ggagaacacc 1320
atgccacccc atctctgcct gcagatcccg gctccctacc tgaagaaagt gcctcaccag 1380
caaggtgcat gatcgtccac cagggcacca ttctggacaa tgttaagaac ctcttagaat 1440
ttgcagaaac actccagttt atagattctg attcttcgtg gtgtgatctc agcagttttg 1500
aattctctga agaagcggca gctttttcac ctagccagca gcccacaggc aaagccttcc 1560
agcttcagca aagagagggc catgggacta gatctgcagg agagcctagc ctgagggtga 1620
ccaggcgagt gctgagcgag gcatccctcg gcccagactc accccaagcg aggcacagca 1680
aggttccgct ggtcgtccta cgaaaaaggc ggggccaggc cagcccccta gccgctggag 1740
agcctagccc ctccctcttt gctgacgtca tcagctcaac tctcaagcgt tcccctgtca 1800
aaagcctacc cttctctccc tcgcagttct tgaacacttc cagcaaccat gaaagctcgg 1860
gcttagatgc acctacctta ccctccactc ctctcattgg tcacaaactg acaccatgtc 1920
gagaccagac tgtgaaaacc cagaaggaaa attccatctt tagaactcca gctatcaaaa 1980
ggtcaatcct cgaaagctct cctcgaactc ccacaccatt caaacatgcc cttgcagctc 2040
aagaaattaa atacggtccc ctgaagatgc tacctcagac cccctcccat gcagtggagg 2100
acctacaaga tgtgattaag caggaatcgg atgaatctgg aattgtggct gagtttcaag 2160
agagtggacc accgttactg aaaaaaatca agcaggaggt ggagtcgcca actgagaaat 2220
cgggaaactt cttctgctca aaccactggg cagagaacag cctgagcacc cagctgttct 2280
cgcaggcgtc tcctgtggca gatgccccaa atattcttac aagctctgtt ttaatgacac 2340
ctgtatcaga agatgaagac aatgtcctca aagcctttac cgtacctaag aacaggcccc 2400
tggtgggtcc cttgcagcca tgcagtggtg cctgggagcc agcatcctgt gggaagacag 2460
aggaccagat gacggcctcc ggtccggctc ggaaatacgt gaacgcgttc tcagctcgaa 2520
ctctggtcat gtgagacatt tccagaaaag cattatggtt ttcagaacac ttaaaagttg 2580
actttcgaca catggctcct cagcgtggag cgctccatgg ctgagagaag agcctgattt 2640
tgttgtggta caacagttga gagcagcacc aagtgcattt ttagttgctt gagatctcac 2700
ttgatttcac acaactaaaa aggatttttt tttttaaaaa taataataat gaataacagt 2760
cttacctaaa ttattaggta atgaattgtg accatttgtt aatatcataa tcagattttt 2820
taaaaaaaat aaaatgattt atttgtattt tagaggatac aacagatcag tatttttgac 2880
tgtggtgaat ttaaaaaaaa aatttacaca aagaaatatc ccagtattcc atgtatctca 2940
gtcactaaac atacacagag agatttttaa aaaccaggag aagcattatt ttgaatgtta 3000
gctaaatccc aagtaatact taatgcaacc ctctaggagc tcatttgtgg ctaataatct 3060
tggaaatatc tttattatac taaaccattt catgaggaga attttgttgt cagcttgctt 3120
gaaaagttat tactgtatga aatagtttta ttgaaaaaat tatattttta ttcagtaatt 3180
taattttgta aatgccaaat ggagaaatgt gttcgctgct atggttttag cctgtagtca 3240
tgctgctagc tagtgtcagg gggcaataga gcttagatgg aaaaaagaga aagagactcg 3300
gtgttagata acggactatg cactagtatt ccagactttt ttatttttat atatatgtac 3360
cttttccttt tgtaattgga aaacttattt gggagaattt tgcatttgtt gtacattttt 3420
gttttttagg attttttttt tttgttgtta ttgtcgattt ataaaagcat tgcacttctt 3480
tttctttttt tgggagattt gtgttgttta tgtcatatgt tttgttttga gttcagcctg 3540
aatgttcatc cgtttgggcg tttttctgac ttggaagaac attctctgta ggtttctaag 3600
tgtacagagc cggaactgcc tcgtggttcc tgggcttcag ggaagacaaa tatggaagtc 3660
aacagccagt ttctgccttg agagcatttg caagaatgct ggccttgaat tctgaaatga 3720
cagtgtatct actgccttgt agcaaaataa agctatcctc ttattttaca tacttcc 3777
<210> 37
<211> 5540
<212> DNA
<213> 智人
<400> 37
attcgcctca caaacaacca cagaaccaca agtgcggtgc aaactttctc caggaggaca 60
gcaagaagtc tctggttttt aaatggttaa tctccgcagg tcactaccag ccaccgagac 120
caacagagtc atttaaggct gcaagcagta tttacaacag agggtacaag ttctatctga 180
aaaaaaaagg agggactatg gcatcaaaca gcctcttcag cacagtgaca ccatgtcagc 240
aaaacttctt ttgggatccg agcaccagcc ggcgcttcag ccccccctcc agcagcctgc 300
agcccggcaa aatgagcgac gtgagcccgg tggtggctgc gcaacagcag cagcaacagc 360
agcagcagca acagcagcag cagcagcagc aacagcagca gcagcagcag gaggcggcgg 420
cggcggctgc ggcggcggcg gcggctgcgg cggcggcagc tgcagtgccc cggttgcggc 480
cgccccacga caaccgcacc atggtggaga tcatcgccga ccacccggcc gaactcgtcc 540
gcaccgacag ccccaacttc ctgtgctcgg tgctgccctc gcactggcgc tgcaacaaga 600
ccctgcccgt ggccttcaag gtggtagccc tcggagaggt accagatggg actgtggtta 660
ctgtcatggc gggtaacgat gaaaattatt ctgctgagct ccggaatgcc tctgctgtta 720
tgaaaaacca agtagcaagg ttcaacgatc tgagatttgt gggccggagt ggacgaggca 780
agagtttcac cttgaccata accgtcttca caaatcctcc ccaagtagct acctatcaca 840
gagcaattaa agttacagta gatggacctc gggaacccag aaggcacaga cagaagcttg 900
atgactctaa acctagtttg ttctctgacc gcctcagtga tttagggcgc attcctcatc 960
ccagtatgag agtaggtgtc ccgcctcaga acccacggcc ctccctgaac tctgcaccaa 1020
gtccttttaa tccacaagga cagagtcaga ttacagaccc caggcaggca cagtcttccc 1080
cgccgtggtc ctatgaccag tcttacccct cctacctgag ccagatgacg tccccgtcca 1140
tccactctac caccccgctg tcttccacac ggggcactgg gcttcctgcc atcaccgatg 1200
tgcctaggcg catttcagat gatgacactg ccacctctga cttctgcctc tggccttcca 1260
ctctcagtaa gaagagccag gcaggtgctt cagaactggg ccctttttca gaccccaggc 1320
agttcccaag catttcatcc ctcactgaga gccgcttctc caacccacga atgcactatc 1380
cagccacctt tacttacacc ccgccagtca cctcaggcat gtccctcggt atgtccgcca 1440
ccactcacta ccacacctac ctgccaccac cctaccccgg ctcttcccaa agccagagtg 1500
gacccttcca gaccagcagc actccatatc tctactatgg cacttcgtca ggatcctatc 1560
agtttcccat ggtgccgggg ggagaccggt ctccttccag aatgcttccg ccatgcacca 1620
ccacctcgaa tggcagcacg ctattaaatc caaatttgcc taaccagaat gatggtgttg 1680
acgctgatgg aagccacagc agttccccaa ctgttttgaa ttctagtggc agaatggatg 1740
aatctgtttg gcgaccatat tgaaattcct cagcagtggc ccagtggtat ctgggggcca 1800
catcccacac gtatcaatat atacatatat agagagagtg catatatatg tatatcgatt 1860
agctatctac aaagtgccta ttttttagaa gatttttcat tcactcactc agtcatgatc 1920
ttgcagccat aagagggtag atattgagaa gcagaaggct caagagagac aattgcaatc 1980
gagcttcaga ttgtttacta tttaagatgt acttttacaa aggaacaaag aagggaaaag 2040
gtatttttgt ttttgttgtt tggtctgtta tcatcaataa cctgttcata tgccaattca 2100
gagaggtgga ctccaggttc aggagggaga agagcaaagc cgcttcctct ctgtgctttg 2160
aaacttcaca ccctcacggt ggcagctgtg tatggaccag tgccctccgc agacagctca 2220
caaaaccagt tgaggtgcac taaagggaca tgaggtagaa tggatgcttc catcacagta 2280
ccatcattca gaataactct tccaatttct gctttcagac atgctgcagg tcctcatctg 2340
aactgttggg ttcgtttttt tttttttttt tcctgctcca agaaagtgac ttcaaaaata 2400
actgatcagg atagattatt ttattttact ttttaacact ccttctcccc ttttcccact 2460
gaaccaaaaa gaaatcccat ccctaaaacc tgccttctcc ttttatgcaa aactgaaaat 2520
ggcaatacat tattatagcc ataatggtat agatagtgat tgcgtttggc tatgtgttgt 2580
tttctttttt tttaaattat gaatatgtgt aaaatctgag gtaacttgct aacgtgaatg 2640
gtcatataac tttaaagata tatttataat tatttaatga catttggacc cttgaaacat 2700
ttcttagtgt attgatatgt tgacttcggt ctctaaaagt gctctttatt aaataacaaa 2760
tttcttcagt ggtctagagc catatctgaa atattgctaa gcaatttcag ttcatccagg 2820
cacaatgtga ttttaaaaaa tacttccatc tccaaatatt ttagatatag attgtttttg 2880
tgatgtatga aggaaatgtt atgtttagtt ctttcagatc tttgaatgcc tctaacacag 2940
ctttgccttc taaagcggta attagggatt taaaaaacaa cctttagccc tttatcagca 3000
tgaaatgctg gagtgatgtg gttttctaat ttctttgggg taattatgac tcttgtcata 3060
ttaaaaagac aagcacaagt aaatcattga actacagaaa aatgttctgt ggtttcatag 3120
ttaagcaaaa ctctaaatcg ccaggcttca tagcaaagac atagtcagct aaaagccgca 3180
catgtggata gagggttcaa ttatgagaca cctagtacag gagagcaaaa ttgcaccaga 3240
gattcttaac caaccagcct taccaaacaa cacaacaggg gaaccccaat ctgccttacc 3300
caaggcccca ctggcagctt tccacagaat ttgcatttag aggagcagaa tgacatcact 3360
gtcctttggg agtaggtcct ctgaaaaggc agcaggttcc agcaggtagc tgagctgaga 3420
ggacatatgg cccacgggga cctacagaca gcctttgaca tttgtatttc ttacaatgga 3480
gggccaagga gggcaagggg ctgtggagtt tggtgtctac tagtgtgtat gaatttgagc 3540
tagagtcctt ctgtggcatg cactttgacc actcctggca gtcacatggc agatttccaa 3600
gtgcaaatcc ttaatccaaa caaggatcat ctaatgacac caccaggcca atccctgctc 3660
tcctccccga aaagtcaggg tcccttcatt ggaatcctcc acccacccaa gcagaattta 3720
gcagagattt gccttcaaac cctaacggcc cccttgttct ctggtccttc tcaaacccac 3780
ctttgtaggc cacccagcat tgcaggacag cgtgtggggc agctggacct gtgcttcctg 3840
cctgggagtc tcccttggaa ttcatcctga ctccttctaa taaaaatgga tgggaaagca 3900
aaacactttg ccttctaaag gccgtatacc aagtatgctt agataaataa gccacttttc 3960
tattacttaa gtaagaagga agtagtaatt gatactattt attgtttgtg tgtggtagct 4020
tgaagcacac cactgtccat ttatttgtaa gtgtaaaata tgtgtgtttg tttcagcagc 4080
acttaaaaaa gccagtgtct ggttacacat ttcaatttta attaattgac ataaaaatgc 4140
taccgccagt gccagctgca tcctatttaa ttaaaaaggt actatatttg tacattattt 4200
tttaatgtta aaagggcttt tttaagttta cagtacacat accgagtgac tttagggatg 4260
cttttgtgtt gaaatgttac tatagtggct gcaggcagca acccagaaac actttagaag 4320
ctttttttcc ttgggaaaaa ttcaagcact tcttccctcc accctcactc caaccacccc 4380
aatgggggta attcacattt cttagaacaa attctgccct tttttggtct agggattaaa 4440
attttgtttt tctttctttc tttttttttt tttttcactg aacccttaat ttgcactggg 4500
tcatgtgttt gatttgtgat ttcaagacca aagcaaagtc ttactactac tgtggaacca 4560
tgtactagtt cctgggaatt aaaatagcgt ggttctcttt gtagcacaaa cattgctgga 4620
atttgcagtc ttttcaatgc agccacattt ttatccattt cagttgtctc acaaatttta 4680
acccatatca gagttccaga acaggtacca cagctttggt tttagattag tggaataaca 4740
ttcagcccag aactgagaaa ctcaacagat taactatcgt ttgctcttta gacggtctca 4800
ctgcctctca cttgccagag ccctttcaaa atgagcagag aagtccacac cattagggac 4860
catctgtgat aaattcagaa gggaggagat gtgtgtacag ctttaaggat tccctcaatt 4920
ccgaggaaag ggactggccc agaatccagg ttaatacatg gaaacacgaa gcattagcaa 4980
aagtaataat tatacctatg gtatttgaaa gaacaataat aaaagacact tcttccaaac 5040
cttgaatttg ttgtttttag aaaacgaatg catttaaaaa tattttctat gtgagaattt 5100
tttagatgtg tgtttacttc atgtttacaa ataactgttt gctttttaat gcagtacttt 5160
gaaatatatc agccaaaacc ataacttaca ataatttctt aggtattctg aataaaattc 5220
catttctttt ggatatgctt taccattctt aggtttctgt ggaacaaaaa tatttgtagc 5280
attttgtgta aatacaagct ttcattttta ttttttccaa ttgctattgc ccaagaattg 5340
ctttccatgc acatattgta aaaattccgc tttgtgccac aggtcatgat tgtggatgag 5400
tttactctta acttcaaagg gactatttgt attgtatgtt gcaactgtaa attgaattat 5460
ttggcatttt tctcatgatt gtaatattaa tttgaagttt gaatttaatt ttcaataaaa 5520
tggctttttt ggttttgtta 5540
<210> 38
<211> 5740
<212> DNA
<213> 小家鼠
<400> 38
atgcttcatt cgcctcacaa acaaccacag aaccacaagt gcggtgcaaa ctttctccag 60
gaagactgca agaaggctct ggcgtttaaa tggttaatct ctgcaggtca ctaccagcca 120
ccgagaccaa ccgagtcagt gagtgctcta accacagtcc atgcaggaat atttaaggct 180
gcaagcagta tttacaacag agggcacaag ttctatctgg aaaaaaaagg agggactatg 240
gcgtcaaaca gcctcttcag cgcagtgaca ccgtgtcagc aaagcttctt ttgggatccg 300
agcaccagcc ggcgcttcag ccccccctcc agcagcctgc agcccggcaa gatgagcgac 360
gtgagcccgg tggtggctgc gcagcagcag caacagcagc agcagcagca gcaacagcag 420
cagcaacaac agcaacagca acaacagcag cagcagcagc agcagcagga ggcggccgca 480
gcagcagcgg cggcagcggc ggcggcagca gcggcggcgg ccgcagtgcc ccgattgagg 540
ccgccgcacg acaaccgcac catggtggag atcatcgcgg accacccggc cgaactggtc 600
cgcaccgaca gtcccaactt cctgtgctcc gtgctgccct cgcactggcg gtgcaacaag 660
accctgcccg tggccttcaa ggttgtagcc ctcggagagg taccagatgg gactgtggtt 720
accgtcatgg ccgggaatga tgagaactac tccgccgagc tccgaaatgc ctccgctgtt 780
atgaaaaacc aagtagccag gttcaacgat ctgagatttg tgggccggag cggacgaggc 840
aagagtttca ccttgaccat aacagtcttc acaaatcctc cccaagtggc cacttaccac 900
agagctatta aagtgacagt ggacggtccc cgggaaccaa gaaggcacag acagaagctt 960
gatgactcta aacctagttt gttctctgat cgcctcagtg atttagggcg cattcctcat 1020
cccagtatga gagtaggtgt cccgcctcag aacccacggc cctccctgaa ctctgcacca 1080
agtcctttta atccacaagg acagagtcag attacagatc ccaggcaggc acagtcttcc 1140
ccaccgtggt cctatgacca gtcttacccc tcctatctga gccagatgac atccccatcc 1200
atccactcca ccacgccgct gtcttccaca cggggcaccg ggctacctgc catcactgac 1260
gtgcccaggc gtatttcaga tgatgacact gccacctctg acttctgcct ctggccttcc 1320
tctctcagta agaagagcca ggcaggtgct tcagaactgg gccctttttc agaccccagg 1380
cagttcccaa gcatttcatc cctcactgag agccgcttct ccaacccacg aatgcactac 1440
ccagccacct ttacctacac cccgccagtc acgtcaggca tgtccctcgg catgtccgcc 1500
accactcact accacacgta cctgccacca ccctaccccg gctcttccca aagccagagt 1560
ggacccttcc agaccagcag cactccatat ctctactatg gtacttcgtc agcatcctat 1620
cagttcccaa tggtacccgg gggagaccgg tctccttcca ggatggtccc accatgcacc 1680
accacctcga atggcagcac gctattaaat ccaaatttgc ctaaccagaa tgatggtgtt 1740
gacgctgacg gaagccacag cagttcccca actgttttga attctagcgg cagaatggat 1800
gagtctgttt ggcggccata ttgaaattcg tcaaccatgg cccagtggca tgggggccac 1860
atcccgcatg tgttaatata tacatatata aagagagtgc ctatatatgt atattgatta 1920
gctaactaga agatttctca ttcaatccct agtcatgatc ttgcaaccct aagagggtgg 1980
gggcagtcat aactgggttt catattgttt actatttaag atgtcccctt taccaaggaa 2040
caaaccgtca aaggtgttgt ctggtctgtt ttcataagtg acctgttccc acgccggttc 2100
agagaggtgg actctgggtc tgggaggaag gagagacact tcctctctgt gctttgaaac 2160
cacagcctct gctgtgtggc agccggtaca ctctgcagac ccgcttacag agtcagatgt 2220
ggtgcactca gaaagggaca agaggcagag tggctgcttc tgtccgctgc cgtccactct 2280
gccgtccacc tgttccaaag ttttccttca gacttgctgc aggtactcat ttgaactttt 2340
gagttcactt tttttttttc ctattctaag aaagtgactt caaaaatact gatcaggaca 2400
gataatttta ttttaccttt tatattttct cacttccccc atttaaccaa aaagaaatcc 2460
cgttccccct cccccgttcc ttctgcttct ccctttatgc aaactgaaaa tggcaatgcc 2520
ttattattat agccataatg gtatagtgtt tgagttggct gtgtgttatg tgtttttttc 2580
tttttttttc ttttttaaat tatgaatatg tgtaaaatct gaagtaactt gctaacgtga 2640
atggtcatat aactttaaag atatatttat aattatttaa tgacatttgg acatttggaa 2700
catttcttag tgtaatgata tgttgacttc ggtctctaaa agtgtgcttc ttcttcaata 2760
ccaagtttct tcagtgggct agagccatat cggaaatatt gctaagcaat ctcaattcct 2820
tcaggcataa tgtgattttt tttttttttt gaagataact cccatctcca aatagtttag 2880
atgtagtttg ttttcacgat gtatgaagga gatgctctgt ttctttcttt caggcatttg 2940
attgcctctg acacagcttt gccttttaaa gcaataatta gggattaaaa taacaaaaac 3000
aaaacaaaag ccacctatag ccctttaaca cttaacgtgg cccctttact agcatgaaat 3060
gctggagaca tgtggtttcc taatttctcc attttggggg tggtgggagg ggggagggtg 3120
gccattatga ctcttatcat attaaaaagc caagcacaag tgattggttg aactgcagaa 3180
aagtgttctg tggtctctga gttgagcaaa actctaaatt gcaggcttcg tggttgaggg 3240
cctagtcagc tgaaagccac gcgtgtggta aaggctcagg catggcttgg agaacctagg 3300
aacacattag gagcctgcac ctaccagcct caccatacag ccattcaggg gaacccaaaa 3360
agtgccttac ccaaggaggg cccccagcag ctttccagga agtcgaatga agtcgctgtc 3420
ctcggggaac tggtcagctg aagtagcaac cggtagctga tgtcagtaga caacagaacc 3480
tgtggggacc tccaggaaac ctttgacatt ggaggctttc attaggcagg gccaacaaga 3540
gcagggaagg ccatgtaccc attggtatct gccattgtgt gtgagtttga gatccagccc 3600
tccttggagg atgtactgtg atcattcctg gtaccttagg gccaatccct aagtgtggct 3660
tcctaatcca ggccagggat cattcagtga taccaccagg ccaatcccag cattcctcct 3720
gcacaaagtg tttgtgtgtg gggggataga ttggggtggg gccaccttca tttgaatcct 3780
gagtcattct aagagttctg caagcttttg ccttcagcac cctatacccc ctcgctctct 3840
gttccttctc aggttgacct ttgtcccaat gcgggacagt ccagaggcag atggggacct 3900
atgtgtgcct ccaacctgcg ttttcctcag aattcatcct gactccctct gacacagatt 3960
gagggggggg ggaagaaacc caacccgcac caaagcaaaa cactttgcct tctaaaggct 4020
gtgcaccaag tagacgcaga tggtcagccc acctttgtgt ttccttaaga tggaaattgt 4080
aactgatgct atttattgtt tgtgtgtggt agcttgaagc acaccacggt ccatgtgttt 4140
gtctgatacc tatttcagca gcatttacaa aagccagtgt ctggttacac ttttcagttt 4200
tcattaatca acatgaaaat gttaccattg gtgccagctg caccctattt aattttttta 4260
agggcactat atttgtacat ttcgttttta atgttaaagg gcttcttaaa gtttacagta 4320
cagttatcaa gggaatagag gggatgcatt agtgcctaaa tgttattcta gtggctgcag 4380
gcagcaaccc agaagcagtt ttgaaaacag gttgtttccc tctgtcctcc cttatttggg 4440
aaaattcaag tgctttcttc acctttcagg cacctcacgg tgactcccgt tacttagagc 4500
agtctgtcgt cgtcttcttc ttcttcctct tcctcttcct cttcctcttc ctcttcctct 4560
tcctcttcct cttcctcttc ctcttcttct tcttcttctt cttcttcttc ttcttcttct 4620
tcctcctagg gtttaaaatc ccccttcctc ttcccttatc tcttaaactc ttcatttgca 4680
ctgggtcaca cgtatgattt gtggttttaa gaccaaagca atgtcttatt actcttctgg 4740
agccgtttat gtgtactaac caacccttcc ctccacttcc ctgggtttag atgcacacgg 4800
ttctcaaagg agcacaaaca tggccagatt cacagtggga cccacacagc catgttaaaa 4860
aaaaaaacaa aaaaaaacct cttcacttgt ctgagaattt taacctgggc cccaattgct 4920
aacgggcacc atggcttggg tttcaggtta gggaacgttg cccagtgagt aacagaaaga 4980
cttaactgat ttaattagtt tgccctcatc cttcactcca agaccctaag aaaccgatca 5040
gagaaacatc tccacaccat tagaggttga gaagggagga gccatgtggg ggttccctcc 5100
gctcggagga aaggcactga ctgacctagt tagagtggta gcagaagcac ccatggtatc 5160
tgagagagca ataaacaata aaagatgatc ctcccaagct tagaatttgt tgttcttaaa 5220
gaagacgatg catctaaaac aaagaatttt tttttctatg tgggaacttt cttcgttgtc 5280
tgtttacttc atgtttacaa ataattgttt gctttttaat gcagtacttt aaaaaatata 5340
tcagccaaaa ccataactta cagtaatttt tttaggtatt ctgaataaaa ttccatgtct 5400
tttgatatgt ctactgttct taggtttctg tggaacaaca acaacaacaa caacaaaatt 5460
gtagcatttt gtgtaaatac agctttcgtt cttatttttt atttttctga ttgctattgc 5520
ccaagatttg ctttctatgc acgtattgta caaattgtgc tttgtgccac aggtcatgat 5580
cgtggatgag tttactctga acttcaaagg gactatttgt attgtatgtt gcaactgtaa 5640
attgaattat ttggcatttc cccctctcat gattgtaata ttaatttgaa gtttgaattt 5700
aattttcaat aaaaaggctt tttttttcct tttggttttg 5740
<210> 39
<211> 4978
<212> DNA
<213> 智人
<400> 39
ggtttccgga gctgcggcgg cgcagactgg gagggggagc cgggggttcc gacgtcgcag 60
ccgagggaac aagccccaac cggatcctgg acaggcaccc cggcttggcg ctgtctctcc 120
ccctcggctc ggagaggccc ttcggcctga gggagcctcg ccgcccgtcc ccggcacacg 180
cgcagccccg gcctctcggc ctctgccgga gaaacagttg ggacccctga ttttagcagg 240
atggcccaat ggaatcagct acagcagctt gacacacggt acctggagca gctccatcag 300
ctctacagtg acagcttccc aatggagctg cggcagtttc tggccccttg gattgagagt 360
caagattggg catatgcggc cagcaaagaa tcacatgcca ctttggtgtt tcataatctc 420
ctgggagaga ttgaccagca gtatagccgc ttcctgcaag agtcgaatgt tctctatcag 480
cacaatctac gaagaatcaa gcagtttctt cagagcaggt atcttgagaa gccaatggag 540
attgcccgga ttgtggcccg gtgcctgtgg gaagaatcac gccttctaca gactgcagcc 600
actgcggccc agcaaggggg ccaggccaac caccccacag cagccgtggt gacggagaag 660
cagcagatgc tggagcagca ccttcaggat gtccggaaga gagtgcagga tctagaacag 720
aaaatgaaag tggtagagaa tctccaggat gactttgatt tcaactataa aaccctcaag 780
agtcaaggag acatgcaaga tctgaatgga aacaaccagt cagtgaccag gcagaagatg 840
cagcagctgg aacagatgct cactgcgctg gaccagatgc ggagaagcat cgtgagtgag 900
ctggcggggc ttttgtcagc gatggagtac gtgcagaaaa ctctcacgga cgaggagctg 960
gctgactgga agaggcggca acagattgcc tgcattggag gcccgcccaa catctgccta 1020
gatcggctag aaaactggat aacgtcatta gcagaatctc aacttcagac ccgtcaacaa 1080
attaagaaac tggaggagtt gcagcaaaaa gtttcctaca aaggggaccc cattgtacag 1140
caccggccga tgctggagga gagaatcgtg gagctgttta gaaacttaat gaaaagtgcc 1200
tttgtggtgg agcggcagcc ctgcatgccc atgcatcctg accggcccct cgtcatcaag 1260
accggcgtcc agttcactac taaagtcagg ttgctggtca aattccctga gttgaattat 1320
cagcttaaaa ttaaagtgtg cattgacaaa gactctgggg acgttgcagc tctcagagga 1380
tcccggaaat ttaacattct gggcacaaac acaaaagtga tgaacatgga agaatccaac 1440
aacggcagcc tctctgcaga attcaaacac ttgaccctga gggagcagag atgtgggaat 1500
gggggccgag ccaattgtga tgcttccctg attgtgactg aggagctgca cctgatcacc 1560
tttgagaccg aggtgtatca ccaaggcctc aagattgacc tagagaccca ctccttgcca 1620
gttgtggtga tctccaacat ctgtcagatg ccaaatgcct gggcgtccat cctgtggtac 1680
aacatgctga ccaacaatcc caagaatgta aactttttta ccaagccccc aattggaacc 1740
tgggatcaag tggccgaggt cctgagctgg cagttctcct ccaccaccaa gcgaggactg 1800
agcatcgagc agctgactac actggcagag aaactcttgg gacctggtgt gaattattca 1860
gggtgtcaga tcacatgggc taaattttgc aaagaaaaca tggctggcaa gggcttctcc 1920
ttctgggtct ggctggacaa tatcattgac cttgtgaaaa agtacatcct ggccctttgg 1980
aacgaagggt acatcatggg ctttatcagt aaggagcggg agcgggccat cttgagcact 2040
aagcctccag gcaccttcct gctaagattc agtgaaagca gcaaagaagg aggcgtcact 2100
ttcacttggg tggagaagga catcagcggt aagacccaga tccagtccgt ggaaccatac 2160
acaaagcagc agctgaacaa catgtcattt gctgaaatca tcatgggcta taagatcatg 2220
gatgctacca atatcctggt gtctccactg gtctatctct atcctgacat tcccaaggag 2280
gaggcattcg gaaagtattg tcggccagag agccaggagc atcctgaagc tgacccaggt 2340
agcgctgccc catacctgaa gaccaagttt atctgtgtga caccaacgac ctgcagcaat 2400
accattgacc tgccgatgtc cccccgcact ttagattcat tgatgcagtt tggaaataat 2460
ggtgaaggtg ctgaaccctc agcaggaggg cagtttgagt ccctcacctt tgacatggag 2520
ttgacctcgg agtgcgctac ctcccccatg tgaggagctg agaacggaag ctgcagaaag 2580
atacgactga ggcgcctacc tgcattctgc cacccctcac acagccaaac cccagatcat 2640
ctgaaactac taactttgtg gttccagatt ttttttaatc tcctacttct gctatctttg 2700
agcaatctgg gcacttttaa aaatagagaa atgagtgaat gtgggtgatc tgcttttatc 2760
taaatgcaaa taaggatgtg ttctctgaga cccatgatca ggggatgtgg cggggggtgg 2820
ctagagggag aaaaaggaaa tgtcttgtgt tgttttgttc ccctgccctc ctttctcagc 2880
agctttttgt tattgttgtt gttgttctta gacaagtgcc tcctggtgcc tgcggcatcc 2940
ttctgcctgt ttctgtaagc aaatgccaca ggccacctat agctacatac tcctggcatt 3000
gcacttttta accttgctga catccaaata gaagatagga ctatctaagc cctaggtttc 3060
tttttaaatt aagaaataat aacaattaaa gggcaaaaaa cactgtatca gcatagcctt 3120
tctgtattta agaaacttaa gcagccgggc atggtggctc acgcctgtaa tcccagcact 3180
ttgggaggcc gaggcggatc ataaggtcag gagatcaaga ccatcctggc taacacggtg 3240
aaaccccgtc tctactaaaa gtacaaaaaa ttagctgggt gtggtggtgg gcgcctgtag 3300
tcccagctac tcgggaggct gaggcaggag aatcgcttga acctgagagg cggaggttgc 3360
agtgagccaa aattgcacca ctgcacactg cactccatcc tgggcgacag tctgagactc 3420
tgtctcaaaa aaaaaaaaaa aaaaaagaaa cttcagttaa cagcctcctt ggtgctttaa 3480
gcattcagct tccttcaggc tggtaattta tataatccct gaaacgggct tcaggtcaaa 3540
cccttaagac atctgaagct gcaacctggc ctttggtgtt gaaataggaa ggtttaagga 3600
gaatctaagc attttagact tttttttata aatagactta ttttcctttg taatgtattg 3660
gccttttagt gagtaaggct gggcagaggg tgcttacaac cttgactccc tttctccctg 3720
gacttgatct gctgtttcag aggctaggtt gtttctgtgg gtgccttatc agggctggga 3780
tacttctgat tctggcttcc ttcctgcccc accctcccga ccccagtccc cctgatcctg 3840
ctagaggcat gtctccttgc gtgtctaaag gtccctcatc ctgtttgttt taggaatcct 3900
ggtctcagga cctcatggaa gaagaggggg agagagttac aggttggaca tgatgcacac 3960
tatggggccc cagcgacgtg tctggttgag ctcagggaat atggttctta gccagtttct 4020
tggtgatatc cagtggcact tgtaatggcg tcttcattca gttcatgcag ggcaaaggct 4080
tactgataaa cttgagtctg ccctcgtatg agggtgtata cctggcctcc ctctgaggct 4140
ggtgactcct ccctgctggg gccccacagg tgaggcagaa cagctagagg gcctccccgc 4200
ctgcccgcct tggctggcta gctcgcctct cctgtgcgta tgggaacacc tagcacgtgc 4260
tggatgggct gcctctgact cagaggcatg gccggatttg gcaactcaaa accaccttgc 4320
ctcagctgat cagagtttct gtggaattct gtttgttaaa tcaaattagc tggtctctga 4380
attaaggggg agacgacctt ctctaagatg aacagggttc gccccagtcc tcctgcctgg 4440
agacagttga tgtgtcatgc agagctctta cttctccagc aacactcttc agtacataat 4500
aagcttaact gataaacaga atatttagaa aggtgagact tgggcttacc attgggttta 4560
aatcataggg acctagggcg agggttcagg gcttctctgg agcagatatt gtcaagttca 4620
tggccttagg tagcatgtat ctggtcttaa ctctgattgt agcaaaagtt ctgagaggag 4680
ctgagccctg ttgtggccca ttaaagaaca gggtcctcag gccctgcccg cttcctgtcc 4740
actgccccct ccccatcccc agcccagccg agggaatccc gtgggttgct tacctaccta 4800
taaggtggtt tataagctgc tgtcctggcc actgcattca aattccaatg tgtacttcat 4860
agtgtaaaaa tttatattat tgtgaggttt tttgtctttt tttttttttt ttttttttgg 4920
tatattgctg tatctacttt aacttccaga aataaacgtt atataggaac cgtaaaaa 4978
<210> 40
<211> 4520
<212> DNA
<213> 小家鼠
<400> 40
aattatgcat ggaggcgtgt cttggccagt ggcggctggg tggggattgg ctggaggggc 60
tgtaattcag cggtttccgg agctgcagtg tagacaggga gggggaacct ggggttccga 120
cgtcgcggcg gagggaacga gccctaaccg gatcgctgag gtacaacccc gctcggtgtc 180
gcctgaccgc gtcggctagg agaggccagg cggccctcgg gagcccagca gctcgcgcct 240
ggagtcagcg caggccggcc agtcgggcct cagccccgga gacagtcgag acccctgact 300
gcagcaggat ggctcagtgg aaccagctgc agcagctgga cacacgctac ctggagcagc 360
tgcaccagct gtacagcgac agcttcccca tggagctgcg gcagttcctg gcaccttgga 420
ttgagagtca agactgggca tatgcagcca gcaaagagtc acatgccacg ttggtgtttc 480
ataatctctt gggtgaaatt gaccagcaat atagccgatt cctgcaagag tccaatgtcc 540
tctatcagca caaccttcga agaatcaagc agtttctgca gagcaggtat cttgagaagc 600
caatggaaat tgcccggatc gtggcccgat gcctgtggga agagtctcgc ctcctccaga 660
cggcagccac ggcagcccag caagggggcc aggccaacca cccaacagcc gccgtagtga 720
cagagaagca gcagatgttg gagcagcatc ttcaggatgt ccggaagcga gtgcaggatc 780
tagaacagaa aatgaaggtg gtggagaacc tccaggacga ctttgatttc aactacaaaa 840
ccctcaagag ccaaggagac atgcaggatc tgaatggaaa caaccagtct gtgaccagac 900
agaagatgca gcagctggaa cagatgctca cagccctgga ccagatgcgg agaagcattg 960
tgagtgagct ggcggggctc ttgtcagcaa tggagtacgt gcagaagaca ctgactgatg 1020
aagagctggc tgactggaag aggcggcagc agatcgcgtg catcggaggc cctcccaaca 1080
tctgcctgga ccgtctggaa aactggataa cttcattagc agaatctcaa cttcagaccc 1140
gccaacaaat taagaaactg gaggagctgc agcagaaagt gtcctacaag ggcgacccta 1200
tcgtgcagca ccggcccatg ctggaggaga ggatcgtgga gctgttcaga aacttaatga 1260
agagtgcctt cgtggtggag cggcagccct gcatgcccat gcacccggac cggcccttag 1320
tcatcaagac tggtgtccag tttaccacga aagtcaggtt gctggtcaaa tttcctgagt 1380
tgaattatca gcttaaaatt aaagtgtgca ttgataaaga ctctggggat gttgctgccc 1440
tcagagggtc tcggaaattt aacattctgg gcacgaacac aaaagtgatg aacatggagg 1500
agtctaacaa cggcagcctg tctgcagagt tcaagcacct gacccttagg gagcagagat 1560
gtgggaatgg aggccgtgcc aattgtgatg cctccttgat cgtgactgag gagctgcacc 1620
tgatcacctt cgagactgag gtgtaccacc aaggcctcaa gattgaccta gagacccact 1680
ccttgccagt tgtggtgatc tccaacatct gtcagatgcc aaatgcttgg gcatcaatcc 1740
tgtggtataa catgctgacc aataacccca agaacgtgaa cttcttcact aagccgccaa 1800
ttggaacctg ggaccaagtg gccgaggtgc tcagctggca gttctcgtcc accaccaagc 1860
gggggctgag catcgagcag ctgacaacgc tggctgagaa gctcctaggg cctggtgtga 1920
actactcagg gtgtcagatc acatgggcta aattctgcaa agaaaacatg gctggcaagg 1980
gcttctcctt ctgggtctgg ctagacaata tcatcgacct tgtgaaaaag tatatcttgg 2040
ccctttggaa tgaagggtac atcatgggtt tcatcagcaa ggagcgggag cgggccatcc 2100
taagcacaaa gcccccgggc accttcctac tgcgcttcag cgagagcagc aaagaaggag 2160
gggtcacttt cacttgggtg gaaaaggaca tcagtggcaa gacccagatc cagtctgtag 2220
agccatacac caagcagcag ctgaacaaca tgtcatttgc tgaaatcatc atgggctata 2280
agatcatgga tgcgaccaac atcctggtgt ctccacttgt ctacctctac cccgacattc 2340
ccaaggagga ggcatttgga aagtactgta ggcccgagag ccaggagcac cccgaagccg 2400
acccaggtag tgctgccccg tacctgaaga ccaagttcat ctgtgtgaca ccaacgacct 2460
gcagcaatac cattgacctg ccgatgtccc cccgcacttt agattcattg atgcagtttg 2520
gaaataacgg tgaaggtgct gagccctcag caggagggca gtttgagtcg ctcacgtttg 2580
acatggatct gacctcggag tgtgctacct cccccatgtg aggagctgaa accagaagct 2640
gcagagacgt gacttgagac acctgccccg tgctccaccc ctaagcagcc gaaccccata 2700
tcgtctgaaa ctcctaactt tgtggttcca gatttttttt tttaatttcc tacttctgct 2760
atctttgggc aatctgggca ctttttaaaa tagagaaatg agtgagtgtg ggtgataaac 2820
tgttatgtaa agaggagagc acctctgagt ctggggatgg ggctgagagc agaagggagc 2880
aaggggaaca cctcctgtcc tgcccgcctg ccctcctttt tcagcagctc ggggttggtt 2940
gttagacaag tgcctcctgg tgcccatggc atcctgttgc cccactctgt gagctgatac 3000
cccaggctgg gaactcctgg ctctgcactt tcaaccttgc taatatccac atagaagcta 3060
ggactaagcc cagaggttcc tctttaaatt aaaaaaaaaa aaaataagaa ttaaagggca 3120
aaacacactg acacagcata gcctttccat atcaaggaat actcagttaa cagcctctcc 3180
agcgctgtct tcaggctgat catctatata aaccctggaa tggttgcaga tcaaatctgt 3240
aaaagagatc cgagagctgt ggcttggcct ctggttcaaa cacaaaggct agagagaacc 3300
tagatatccc tgggttttgt ttacccagta tgcttgtcgg ttggaggtgt gaggtaggcc 3360
aagggcactg gaaagccttt gtcatcaccc tactccctcc ccaacccaga ctccagaccc 3420
tgtttcaggg tcagcctgcc ctgtgggtgc cttactgggc ctagggtcaa cctgccttcc 3480
tttcccactt gaccttgctg gtagtatgtc cccttcccat gtccaaaggc cctctgtcct 3540
gcttctattg ggaatccctg cctcaggacc ttgtgtcgag agggattgcc ttacaggttt 3600
gaacctgcct cagactacag gccctcagca aagctcaggg agtatggtcc ttattctatg 3660
cgcttggttc ccagggatat ctgtaaccac agggcaaaag ctgacatata ctccaggtct 3720
gccctcatat gagtggtgta ttcttggcct cccctgagac tggcaactgt ctgctcccca 3780
ttgggtctcc caggtgaggt ggaacacagt tcctgcacct actgtggcct ccatgtcgct 3840
tgcttgcttc gctcactcag cttactggaa cactgagtgt tcaaggcaag cctttcctga 3900
cagaggcatg gctagattca gtgactcaaa gccacctcat tcagctgatc agtgtctgtg 3960
gaattgtttc cttccagtta accagtgtct gaattaaggg cagtgaggac attgtctcca 4020
agacgaactg cttgccttga ccaccccagc cttctgcttc gagacagtta ctgctctccc 4080
accccatcaa tgttctttag ttatacaata agctgaactt ataaactgaa agggtattta 4140
ggaaggcaag gcttgggcat ttttatggct ttcaatcctg gggacccagg aacaaggtga 4200
gggcttctct ggggctggtg ttgtacctca ggggctctgg gaagtctgtg tgcctgggtt 4260
aaccacccat agtgagcccc tggaactgcc cactttccct ctccttggcc ccacttggcc 4320
ccagcctcac ccagcctgca gactgcttag cctttcagtg cagtggcttg tgttctggcc 4380
actgcactca gattccaatg taaactttct agtgtaaaaa tttatattat tgtgggttgt 4440
tttttgttgt tgtttgtttt tgtatattgc tgtaactact ttaacttcca gaaataaaga 4500
ttatatagga actgtctggc 4520
<210> 41
<211> 8232
<212> DNA
<213> 智人
<400> 41
gatgtctaca gtatcacctt tcttgtagat tggcacttat gcggccaaag gaacaacacc 60
atgttttcta aaaggctgga gaaaatacca caggtgcctc tcctctttcc cttcatcttc 120
atcattttga caaattactc aaagatggag ggtgcagttg aaagccagcc atcatttttt 180
aaaacttctc aggacattgt aacatgcact tgggttgaga actgctactc gagcttctcc 240
aggaggccct tggagcaaat gttttgtaaa caccaatcta agaacattat ctcttggacg 300
ggcatggtgg ctcacacctg taatcccagc actttgggag gccaaggttt gtgtgatttt 360
gctaaaatgc atcaccaaca gcgaatggct gccttaggga cggacaaaga gctgagtgat 420
ttactggatt tcagtgcgat gttttcacct cctgtgagca gtgggaaaaa tggaccaact 480
tctttggcaa gtggacattt tactggctca aatgtagaag acagaagtag ctcagggtcc 540
tgggggaatg gaggacatcc aagcccgtcc aggaactatg gagatgggac tccctatgac 600
cacatgacca gcagggacct tgggtcacat gacaatctct ctccaccttt tgtcaattcc 660
agaatacaaa gtaaaacaga aaggggctca tactcatctt atgggagaga atcaaactta 720
cagggttgcc accagcagag tctccttgga ggtgacatgg atatgggcaa cccaggaacc 780
ctttcgccca ccaaacctgg ttcccagtac tatcagtatt ctagcaataa tccccgaagg 840
aggcctcttc acagtagtgc catggaggta cagacaaaga aagttcgaaa agttcctcca 900
ggtttgccat cttcagtcta tgctccatca gcaagcactg ccgactacaa tagggactcg 960
ccaggctatc cttcctccaa accagcaacc agcactttcc ctagctcctt cttcatgcaa 1020
gatggccatc acagcagtga cccttggagc tcctccagtg ggatgaatca gcctggctat 1080
gcaggaatgt tgggcaactc ttctcatatt ccacagtcca gcagctactg tagcctgcat 1140
ccacatgaac gtttgagcta tccatcacac tcctcagcag acatcaattc cagtcttcct 1200
ccgatgtcca ctttccatcg tagtggtaca aaccattaca gcacctcttc ctgtacgcct 1260
cctgccaacg ggacagacag tataatggca aatagaggaa gcggggcagc cggcagctcc 1320
cagactggag atgctctggg gaaagcactt gcttcgatct attctccaga tcacactaac 1380
aacagctttt catcaaaccc ttcaactcct gttggctctc ctccatctct ctcagcaggc 1440
acagctgttt ggtctagaaa tggaggacag gcctcatcgt ctcctaatta tgaaggaccc 1500
ttacactctt tgcaaagccg aattgaagat cgtttagaaa gactggatga tgctattcat 1560
gttctccgga accatgcagt gggcccatcc acagctatgc ctggtggtca tggggacatg 1620
catggaatca ttggaccttc tcataatgga gccatgggtg gtctgggctc agggtatgga 1680
accggccttc tttcagccaa cagacattca ctcatggtgg ggacccatcg tgaagatggc 1740
gtggccctga gaggcagcca ttctcttctg ccaaaccagg ttccggttcc acagcttcct 1800
gtccagtctg cgacttcccc tgacctgaac ccaccccagg acccttacag aggcatgcca 1860
ccaggactac aggggcagag tgtctcctct ggcagctctg agatcaaatc cgatgacgag 1920
ggtgatgaga acctgcaaga cacgaaatct tcggaggaca agaaattaga tgacgacaag 1980
aaggatatca aatcaattac taggtcaaga tctagcaata atgacgatga ggacctgaca 2040
ccagagcaga aggcagagcg tgagaaggag cggaggatgg ccaacaatgc ccgagagcgt 2100
ctgcgggtcc gtgacatcaa cgaggctttc aaagagctcg gccgcatggt gcagctccac 2160
ctcaagagtg acaagcccca gaccaagctc ctgatcctcc accaggcggt ggccgtcatc 2220
ctcagtctgg agcagcaagt ccgagaaagg aatctgaatc cgaaagctgc gtgtctgaaa 2280
agaagggagg aagagaaggt gtcctcagag cctccccctc tctccttggc cggcccacac 2340
cctggaatgg gagacgcatc gaatcacatg ggacagatgt aaaagggtcc aagttgccac 2400
attgcttcat taaaacaaga gaccacttcc ttaacagctg tattatctta aacccacata 2460
aacacttctc cttaaccccc atttttgtaa tataagacaa gtctgagtag ttatgaatcg 2520
cagacgcaag aggtttcagc attcccaatt atcaaaaaac agaaaaacaa aaaaaagaaa 2580
gaaaaaagtg caacttgagg gacgactttc tttaacatat cattcagaat gtgcaaagca 2640
gtatgtacag gctgagacac agcccagaga ctgaacggca atctttccac actgtggaac 2700
aatgcatttg tgcctaaact tcttttggaa aaaaaaaata taattaattt gtaagtctga 2760
aaaaaaaata tttaatttaa aaaaaattgt aaacttgcaa taatgaaaaa gtgtacttct 2820
gaagaaaact acatgaacgt ttttgttggt attcaagtca gctagtgttt ataattactg 2880
gatattgaat taggggaagc tcggctgccc tagtaacaaa accagcaaac gtcctgatga 2940
caacgaagtg atgacattag ccattcctta gggtaggagg aacagatgga tcttatagac 3000
ctatgacaaa tatatatata aatatatata taaatatata ttaaaaattt agtgactatg 3060
gtaagctttt gttcatttgt ttcagacttt tttctcctgt aaaaaaatag tactgattaa 3120
cttttttaaa agaaagattt tactgtaaat atggattttt ttttttttgg tcttatttct 3180
gtccctttcc ctggtttgtt atcgtaacct gtagtgccaa ctctgcttcc agaggggtag 3240
tgcaggatga aatgctgacc ctgatgttgc ttctcattca taaataagta gaaagttgtt 3300
tctccagtct tttgggaaca caggacttaa aagtcacatc atgtgtagat attacaagca 3360
gcattaccaa gacatggcaa aaagagtttg tctgaattgt aatgttgcgt ttgtgaacct 3420
attctgggat tttcagaggt acaaggttag aatgctacaa tgttaccact gtgccttcca 3480
atgtttatat catcggaaac ataacataat caaagtggct gtgatttaac aaaatgatta 3540
aagtgttacc tacctgtgta gccgaagtag tgtgcagtga ggcgtttctg aatacatggt 3600
cagatttttg gaaaaaaaca aaaacaaaaa aaacaagtaa agttcaaaaa ccgtcaaatg 3660
agaaaattgc aagtagtgtg acagagctga ttgattttgt tgctttcttg attttttttt 3720
tcaaaatggg tttactaaaa tgtagatgac ttaactgcct cctccttcgt ctgaaaaatg 3780
ccaatattca atcatcatgc agcattataa caagccttat aagtcctaaa gcattaagtt 3840
gcactttttt gaggaggggt agtgcagtat ttctctggcc agtatgaatg aagtttatac 3900
ttaccatatt tgatagaaac atagatcaag ctatggcaca gcgactcatc agatagctag 3960
ctttgacgtc tgggcacaat tgaaccaact tccatcgtga atctttataa tgattgactt 4020
tggtgtatag tgcagtaaac aaatagtgct cctagttaag tatttgtcag catccttttg 4080
tctctaactt gtttctattt ttacagccac acaattcttg gcatgtatta agaaaaaaaa 4140
aaatccctgt tcaagtagtt tttccaccta tcagcactga gtaaatgcca taaatccatt 4200
gaaatggtct aaatgttcca tctgttctcc tgttttgcca gttatatagt aatgaaatac 4260
atttgtaaat tttatgcaac aaatggcaaa cgtatcatta ttttgaaatt gtgtatgtaa 4320
aagttatatt tttacatgta gactcttgtt attatgtgtt ttaatacatt gtatcagttt 4380
ttgttttttt ttaaaaactg tggtttaaaa agaagtctca tttaaatgaa atagctacaa 4440
gaatcagaat tttatgttca tttctgaaaa tgtaagaaca aataagatag ttaccacgtg 4500
gtcatctttt acaaacccat aaacattttg attagctgtg tgtgtgttga aaaactgtaa 4560
atatgttcag tagcgataaa actaaaataa ctttgatttg ttgataagtt cctaaaatgt 4620
ggaggtggat taaaacctta ggagaatagc agaaatcaaa cttcatgaaa agttattttg 4680
gggctttcct gtgaaatgta tgaacaaaga ggctcagaga aggacatgga agacaataat 4740
gtatactctc tcctcctccc tgaataatga aaaccatgtg tatttgttcc ctccgtatgt 4800
taaagatttc cttttagtgg tacattctgc actcattttg tatagtctac caaggcgggt 4860
atccctagga acaatattat ataggaagca ggtatactct gatcacattc aggataagtg 4920
tacagaagaa aatacggtgt ttactcttta gggaactgga aacactccct gcattgatgt 4980
acattttaag aatggcactt ttgatacatg ttatcataaa ggtgcttaat agagctgaat 5040
taaagttttt caaatctgta aacaaagcaa aaaagtaaat tgtagtcatt tgattatttt 5100
ttaaattggt gctttatatt ttgttctcac tcagagtaaa agctgcaatt tattgttcac 5160
cagctttgat gtattcatta ctcagtaatg caatacctct attgttgaat tccctttgga 5220
aataagtgaa aattctaacg gccactgaaa gctgctcgct aggttttgct tggtggagaa 5280
acataatctg cacctatcca tattaattgg gttgtatccc cattaaaaaa gaaaaaaagg 5340
gaatgtggcc tttttagtgt gttttttatt gttgttgttt tgtaattatc aaacccaggt 5400
aagatattgg tatcctgcac tggattttca aatgaagttc agcagaagac agttaagatt 5460
aaagtactat acaaaaattt caaaagggtc catactacgc tatctgtatg acgacactta 5520
ggctggggat ctctttcaga aactcggact ttaaaagcaa cttggagcag ttgatccacc 5580
tccacattca agtaatttat gaatatgcag aatagggatc tgttcatcta gaaattttta 5640
ccatttgtct tctgtgtagc tgcaaggaac actaatgttt atacaactgt cagtccaccc 5700
agtggtgcaa ctggttctga ttcagtcttc cgattccttt ttatttttca ctttttccta 5760
tttctgaatt ttttttttta tttgtgatct tgattttgat gaggggttgg ggagtgggga 5820
gggagtcgaa ccaagacttg gagttaagag gattttcatc ttttgcatcc aacaggcaga 5880
atatgatctg tgtccaaaag tgaacttgag tcaggaatga atcaatttca gcataaacaa 5940
gcacaaaaat ttagtctgct ggctgactgg aagcaaaaaa gtcaagatgg aatatgatga 6000
attccaacac aatggggcac caaggccttt aggcctctct ttttattttg ctttggtttt 6060
gtttgttttt ctttagagac atgctctttc tcatgggact tgaagtggac tcatctttgt 6120
gcagtgctgg ttttgccata ctcatttcaa gtattataga catatgtaat ggtgaaaata 6180
tatgaactgt ggcctttttc attcttgtta cttgtgatgc aattaagtga agataagaaa 6240
aaaaaaaaaa aagcagagat ttaccatgta tcagtgcctg gctttttgtt ataaagcttt 6300
gtttgtctag tgctcttttg ctataaaata gactgtagta caccctagta ggaaaaaaaa 6360
aaaactaaat ttaaaaataa aaaatatatt tggcttattt ttcgcaggag caatcctttt 6420
ataccatgaa tattacaaaa aaattgtcag attctgaata tttcttcttt gtagattttt 6480
ggaatcatta tgagtaaaag tttgttactt tattttacta tttaaaagat gttattttac 6540
catgtgttac caagatgaaa ctgtatgggt agcttttttg tttgtttttt gttttgtttt 6600
tgtttttgtt tttgttttta gttgtaggtc gcagcgggga aattttttgc gactgtacac 6660
atagctgcag cattaaaaac ttaaaaaaat tgttaaaaaa aaaaaaaggg aaaacatttc 6720
aaaaaaaaaa aaaaagataa acagttacac cttgttttca atgtgtggct gagtgcctcg 6780
attttttcat gtttttggtg tatttctgat ttgtagaagt gtccaaacag gttgtgtgct 6840
ggagttcctt caagacaaaa acaaacccag cttggtcaag gccattacct gtttcccatc 6900
tgtagttatt cgatgaagtc atgtacatga ccgttctgta gcaataaatg tgccattttt 6960
ataaactgtt tctgacactt gtttcatttc attttgcatt gtccatatag ctatgattct 7020
cttctgtaag taaaacgcat ctatatttca ttttccaagt gttggaggta ttgacagctt 7080
aacaaacaaa acatacaaaa aaaatcacaa aaacaaattg aaaagcaaag cacatgattg 7140
atcaaggaag agatgccctt aatgaaaatg gaacgggatg catgcaaaac aaaaagaaaa 7200
ctgtctagag gattaactaa ttgaaggaat ataattaatg tgtgtgtaac actgaagcta 7260
tgcatttgaa gagctctgaa ctgcaccagt gttttcggtt gtgctgcagg ttgctaagtc 7320
aagtcagcct taaccttttg caccagttgg tcggctgttt ggcagaacat tctcagatct 7380
tttcagtcaa aaatctaaga tgatttattt tgtatcactt tgttaaaagc tgaatattgt 7440
taactacagt taatattaac actgtattta tactttctca aactacatcc gccccaccac 7500
ttctggttgc ctctgttgac tattaatcca gatgtaaaca accagatgtt tttttctaac 7560
ttgtacaaac tgacgtgtgt caactatcat ggaaggaaaa aaatgtacag attaaaatta 7620
ttcagtgtta tgtactgtaa gttaatattt ttgtagaatg gacatcaatc tactttgcaa 7680
aatttggagg ctatttcaac attgcactgt agaaatgtaa agtaatgtat gcaatgtaaa 7740
ggaaagcccg cggtagctga gcgcttcata acagaatgtt ctaatcaagt acgtggtatt 7800
tggggatgtc tccaatattg ctcttgtatt ctttctaatt gggtttagtg actagttgaa 7860
ggaaaatgtt ataacgccat ttggttcaca tgtgaagtgc cctccatagc caaatgttgg 7920
gatttttttt tttttcgttt ttggttggac tgtttgcaga tatttaaatt ttatgaaatt 7980
tccaaagatt ttggttgata accccctttt accttctaaa tgatttgaga tgttcttatg 8040
ttcttactgt gtgttttaaa tatatataaa agagccacaa gcatttagtc ttttagtatt 8100
atatttgatc atataactac tactgaaaag gggtgggggg gaatgtgcct gtgcacccct 8160
acagtatctt gtgtagtgtc tattaacatt gttctctttt agaggaccac attaaaaggt 8220
acattaatct ta 8232
<210> 42
<211> 7462
<212> DNA
<213> 小家鼠
<400> 42
ggagcagccg cggccgcagc gccttctctt tataagccgc agtgcccgga tgtgaatgga 60
ttacaatgta tctttcaggg aaacctatta ttatcaatgt gactcctcgg gggagtcaat 120
gatggtgttg gggaggagga tgatgatgag acgcctctaa acttggaaca agtttaggac 180
tttgaaagag aagagaaaaa aaaatacaac caacaagacc gaagaacaat tataactatc 240
cagtgttgat tatttttata aacaatacga aaaagttgtc ggattttttt ttttaatgat 300
tactttttgg ggggagggaa ttttgttaca gtttgatgat ggaaaatgca aaaaccgagc 360
caggtgcata atcttgtaat ctgtggctaa ccctggaaca ggactgactt ctatttaaaa 420
tactcttttg ggggaacact catgtgagac actaagttct tgcagaagat ttttgtctct 480
ctttttaaag tctctttcct tggaatattg tgagcatatt tgtggccatt gaaggtttgt 540
gtgattttgc taaaatgcat caccaacagc gaatggctgc cttagggacg gacaaagagc 600
tgagtgattt actggatttc agtgcgatgt tttcgcctcc tgtaagcagt gggaaaaatg 660
gaccaacttc tttggcgagt ggacatttca ctggctcaaa tgtagaagac agaagtagct 720
cagggtcctg gggaactgga ggccatccaa gcccgtccag gaactatgga gatgggactc 780
cctatgacca catgactagc agggatcttg ggtcacatga caatctctct ccaccttttg 840
tcaattccag aatacaaagt aaaacagaaa ggggctcata ctcatcttat gggagagaaa 900
acgttcaggg ttgccaccag cagagtctcc tcggagggga catggatatg ggcaatccag 960
gaaccctttc gcccaccaaa cctggctccc agtactatca gtattcaagc aataatgccc 1020
gccggaggcc tcttcacagt agtgccatgg aggtacagac aaagaaagtc cgaaaagttc 1080
ctccgggttt gccgtcttca gtctacgctc cttcagccag cactgccgac tacaacaggg 1140
actcgccagg ctatccttcc tccaagccag cagccagcac tttccctagc tccttcttca 1200
tgcaagatgg ccatcacagc agcgaccctt ggagctcctc cagcgggatg aatcagcccg 1260
gctacggagg gatgctgggc aattcttctc atatcccaca gtccagcagc tactgtagcc 1320
tgcatccaca tgaacgtttg agctatccat cccactcctc ggcagacatc aactccagtc 1380
ttcctccgat gtccacgttc catcgtagtg gcacaaacca ttacagcacc tcttcctgca 1440
caccccctgc caacggaaca gacagtataa tggcaaacag aggaactggg gcagcaggca 1500
gctcgcagac tggagacgct ctagggaaag ccctagcttc gatctattct cctgaccaca 1560
cgaacaacag cttttcctcc aatccttcaa ctcctgtggg ctcccctcct tcactctcag 1620
caggcacagc tgtttggtct agaaatggag gacaggcctc gtcatctccc aattatgaag 1680
gacccttgca ctcactgcaa agccgaatcg aagaccgttt ggaaagactg gacgatgcga 1740
ttcatgttct ccggaaccac gcagtgggcc cgtccacagc tgtgcctggt ggccatgggg 1800
acatgcatgg gatcatggga ccctcccaca acggagcgat gggtagcctg ggctcagggt 1860
acggaactag tcttctctca gccaacagac actcgctcat ggttggggcc caccgtgaag 1920
atggcgtggc tctgagaggc agccattctc tcctgccaaa ccaggttccg gtcccacaac 1980
ttccggtcca gtctgcaact tcccctgact tgaacccacc ccaagaccct tacagaggga 2040
tgccaccagg cctccagggc cagagcgtgt cttctggtag ctctgagatc aaatccgacg 2100
acgagggcga tgagaacctg caagacacaa aatcttctga ggacaagaaa ttagatgacg 2160
acaagaagga tatcaaatca attactaggt caagatctag caataacgat gatgaggacc 2220
tgaccccaga gcagaaggct gagcgcgaga aggaacggag gatggccaat aatgcccgtg 2280
agcgcctgag ggtccgagat atcaacgagg ctttcaagga gcttggccgt atggtgcagc 2340
tccacctgaa gagcgacaag ccccagacca agctcctgat tctccaccag gccgtggctg 2400
tcatcctcag cctggagcag caagttcgag aaaggaatct gaacccgaaa gctgcctgtc 2460
tgaaaagaag ggaggaagag aaggtgtcct cagagcctcc cccactctcc ttggctggcc 2520
cacaccctgg gatgggagac gcagcgaatc acatgggaca gatgtgaaaa ggtccaagtt 2580
gctaccttgc ttcattaaac aagagaccac ttccttaaca gctgtattac cctaaaccca 2640
cataaacact gctccttaac cccgtttttt tttgtaatat aagacaagtc tgagtagtta 2700
tgaatcgcag acgcaagagg tttcagcatt cccaattatc aaaaaacaga aaaacaaaca 2760
aaaaaatgaa tgaaagaaag aaagaaagaa aaaaatgcaa cttgagggac gacttcttta 2820
acatatcact ctgaatgtgc gaagcggtat gtacaggctg agacacagcc cagagactga 2880
atggcaatcc tcccacactg tggagcaatg catttgtgcc taaacttctt ttggaaaaaa 2940
aaaatataat taatttgtaa gtctgaaaaa aatatttaat ttaaaaaaaa attgtaaact 3000
tgcaataatg aaaaagtgta cttctgaaga aaacgacatg aacgtttttg ttggtattca 3060
cgtcagctag tgtttctaat taccggatat tgaatagggg aagcccggct gccctcgtaa 3120
caaaaccagc aaacgtcctg atggcaacga agtgatgaca ttagccattc cttagggtag 3180
gagggacaga tggatgttat agacctatga caaatatata tataaatata tatataaata 3240
tatattaaaa atttagtgac tatggtaagc ttttgttgat ttgtttcaga cttttttctc 3300
ctgtaaaaaa atagtactga ttaacttttt taaaagaaag attttactgt aaatatggat 3360
tttttttttt gtctgatttt tgtcccttcc cccggtttgt tatcgtaacc tgtagtgcca 3420
actctgcttc cggaggggca gtgcaggacg aaatgctgac cctgaagttg cttctcattc 3480
acaaatagta aaaagttgtt tctccagtct tttgggaaca caggacttaa aagtcacatc 3540
atgtgtagga attacatgca gcattgcccg ggcgaggcaa aaagcgtttg tctggcttgt 3600
ggcgctgccc ttgttaccct cccctgggat tttcagaggt acacggttag aatgctacaa 3660
tgttaccact gtgccttcca atgtttatat catcggaaac ataacataat caaagtggct 3720
gtgatttaac aaaaaaaacg attcaagtgt tacctacctg tgtagccgaa gtagtgtgca 3780
gtgaccgaga cgtttctgaa tacatggtca gatttttttt ggaaaaaata caaaaattaa 3840
aaaaaaaaaa aaaaaagaaa aaaagaaaaa aaaactaaaa aagaaagtca agttcaaaaa 3900
ccgtcaaatg agaaaattgc aaggagtgtg acagagctga ttgatttttg ttgctttctt 3960
gatttttttt tcaaaatggg tttactaaaa agtagatgac ttacctgcct cctccttcgt 4020
ctgaaaaaaa aaaaaaatgc caaccaatca tgcagcatta taacaagcct tataagccct 4080
aaagcattaa gttgcacttt tgtgaggagg ggtaacgcag tattctctct ggccagtatg 4140
agtgaagttt atacttaaca tttgatagaa acatagatca aactacggca cagcaactca 4200
tcagatagct agcgttgact ctgggcacaa ttgaaccaat tcccatcgta agtctttcca 4260
acaatggact ttggtgtgta gtgcagtgaa cacataggac tcctacgtaa gcatttgtca 4320
gcatcctttt gtctctaact cggttctgtt ttgacagcca cacaatcttg gcatgtatta 4380
aggaaaaaaa aaatccctgt tgaagtagtt tttccaccta tcagcactga gtaaatgcca 4440
taactccgcg gaaatggtct aaatacccca tttgttgtcc tgaactacca gttacatagt 4500
gacgaaacac atctgtaaat tttatgcaac caatggcaaa cctatcatta ttttgaaact 4560
gtgtatgtaa aagttatatt tttacatgta gactcttgtt attatgtgtt ttaatacatt 4620
gtatcagttt tttgtttttt tttaaactgt gtggttttaa aaagtcattt aaatgaaata 4680
gtgagctaca agaatctgaa atttatgttc atttctgaaa atgtaagaac aaataagata 4740
gttaccacgt ggtcaccttt tacaaaccca tgaacatttt gattagctgt gtgcatgtgt 4800
gtgcgtgtgt gctcttgcgc gtgtgtgtgt gtgtgtgtgt gtgtgtatgt gtgtgtgttg 4860
aaaattgtaa atatgttcag tagcgataaa actaaaatgc tttgatttgt tgagaagttc 4920
ctaaaatgtg gaggtggatt gaaaatgtag gggaatagca ggaatcaaat ctcataaaaa 4980
gttcttcggg gactttgctg tgatgcggtg gcacaaaggt gctccaagaa gggcaaagaa 5040
gaaagacagt aacttcccct cctccctgaa cgatggaaaa catgtgtacg tggtctctca 5100
ccatgttaaa gattttcttt ccgtgataca ttctgcactc attttgtata gtctgccaag 5160
gcgggtatcc ctaggaacaa tattattata taggaaacag gtatcgtccg atcacattca 5220
ggagaagcgt atagaaaaga atatggtgtt tactctttag ggaactggaa atcctccccg 5280
cattgatgga tatcttcaga gtggcacttt tgatacatgt tatcataaag gtgcttacta 5340
aagcagaatc aaagtttttc aactctgtaa acaaagcaaa aaattaaatt tttaaattaa 5400
atcatttgag attttttttt tcaattggtg cttttatatt ttgttctcac tcggacagag 5460
aaaaagctgc aatttcatgt tctcaccagc tttgatgtat tcattacttg gtaatgtaat 5520
atggctattg tcaaattcct tttggaaata agcaaaagac tccccaaagg ccagcagcag 5580
ctgctggcta ctttctgctt ggtgcggaaa cctgatctga ccctctttgt agtaatcagg 5640
tgtatctcca gttttaaaaa gaaggagaaa ggaaatgtgg ccgttttaac gtgttggttt 5700
tgttttgttt tgttttgttt tgttttcctt gttgttattt tgtaattatc aaacccaggt 5760
aagatattgg tattcctgca ctggattttt gaaagaaact tagcagaagt caggattaaa 5820
atactacaca aacatttcat aagtgttcat cctatactag acatacacga aggcggtgag 5880
gcttaggtgc aggatcggtt taagagactt tgaaagcaac ttggaacagt tgatccacct 5940
ccacattaaa gtaaattatg aatatgcaga attagggatc tgtccatctt ggagttgtta 6000
ctctttttgt cttctgtatg gcagtgatga acactaatgc tttgacagct ttcagcccac 6060
ccagtggtcc aactgattcc aattcagtct tccgattcct ggttttgttt tgtctttcca 6120
cttttttttt cctatcttga ttttattgtt attgttattg ttattattat tattattatt 6180
attattaata ttcatgatgt ttgttttgat gagggattgg gaagtgggag ggagtcgaac 6240
tgagactagg ggctgagagg attttttttt ttccatcttt gcatccaaca ggcagaatat 6300
ggtctgtgtc caaaacggaa cttaagtcag gaaggaaacc attcagcata aacaagcaca 6360
acatgtagtc tgccggctga ctggaagcat aaataaataa ataaataaca catacggagg 6420
tgaagatgga atgtgctgga ttccaagaca atggggcacc aaggcctgag ggcctcctct 6480
tgactttgct ttggttatgt ttgttttctt tagagatgtc ttttctcatg ggacttgaag 6540
tgactcatct ctgtgcagta ctggtttcgc catatgctca tttcaagtat tatagacata 6600
tgtaatggtg aaatatatga actgtggcct ttttcattct tgttacttgt gatgcaatta 6660
agtgaagata agaaaaaaaa aaagcagaga tttaccatgt atcagtgcct ggctttttgt 6720
tataaagctt cgtctgtcta gtgctctttt tgctataaaa aatagactgt agtacaccct 6780
agtaggaaaa aaaaactaaa tttaaaaata aaaaaatata tttggcttat ttttcgcagg 6840
agtaatcctt ttataccatg gatattacaa aaaaaaatgt cagattctga gtatttcttc 6900
tttgtagatt tttggaatca ttatgagtaa aagtttgtta ctttattttg ctatttaaaa 6960
gatgttattt taccatgtgt tactgaaagg aaactgtatg gtagagcttc tgtttgtttt 7020
tgttttcagg ttttttttgt ttgtttgttt ttagttgtag gtcgcagtat gaactttttt 7080
tttgtttctc gttatgtttt gttttgtttt tgcgactgta cacatagctg cagcattaaa 7140
aacttttaaa aaattgttta aaaaaaaaga aaaaaaggga aaacgtttta aaaaaaaaga 7200
taaacagtta caccttgttt tcaatgtgtg gctgagtgcc tcaatttttt catgtttttg 7260
gtgtatttct gatttgtaga agtgtccaaa caggttgtgt gccggacttc cttcaagagg 7320
cccacagccc agcttggtct agacctgttc ccatctgtag ttactcgatg aagtcatgta 7380
catgaccgtt ctgtagcaat aaatgtgcca tttttataaa ctgtctctga cacttttttc 7440
atttcacctc tcgtgcacat ag 7462
<210> 43
<211> 6104
<212> DNA
<213> 智人
<400> 43
gagccgagcg cggtggtgag gccgcctcag cgaaaaaaat gtccgcctga agagacccac 60
aagttctatt cggggggacc gacagcccgc cccgggagga aggggcggcc aggcccgaaa 120
gccgcctccc cctcccagac ccgagagctc gtgcggggca aagtgaaccg agccgctggg 180
cggtgcaagg ggaagcccaa gcccgttctc ccggccaaag tgaactttaa tcggggtggt 240
tggatgcgga gacggggcgg cagaagtggc cgaagatgaa tccccagcaa caacgcatgg 300
ccgctatagg gaccgacaag gagctgagcg acctactgga cttcagtgcg atgttttccc 360
cacctgttaa tagtgggaaa actagaccaa ctacactggg aagcagtcaa ttcagtggat 420
caggtattga tgaaagagga ggtacaacat cttggggaac aagtggtcaa ccaagtcctt 480
cctatgattc atctagaggt tttacagaca gccctcatta cagtgatcac ttgaatgaca 540
gtcgattagg agcccatgaa ggcttgtccc caacaccttt catgaactca aatctgatgg 600
gaaaaacatc agagagaggc tcattttccc tgtacagcag agatactgga ttaccaggct 660
gtcaatctag tctcctgaga caagatctgg ggcttgggag cccagcacag ctatcttctt 720
caggaaaacc tgggacagca tactattcat tctctgctac aagttccagg aggagaccac 780
tccatgactc tgcagcgctt gatcccttgc aagcaaaaaa agtcagaaag gtgcctcctg 840
gtttgccttc ttctgtatat gcaccatccc caaattcaga tgatttcaac cgtgaatctc 900
ctagttatcc atctcctaag ccaccaacca gtatgttcgc tagcactttc tttatgcaag 960
atgggaccca caattcttct gacctttgga gttcatcaaa tgggatgagc cagcctggtt 1020
ttggtggaat tctggggacc tccacttccc acatgtctca atccagtagt tatggcaacc 1080
ttcattcaca tgaccgcttg agttatcctc cacactcagt ttcaccaaca gacataaaca 1140
cgagtcttcc accaatgtcc agctttcatc gcggcagtac cagcagttca ccttacgttg 1200
ctgcctcaca cactcctccc atcaatggat cagacagcat tctaggaacc agagggaatg 1260
ctgctggaag ctcacagaca ggtgatgcac ttggaaaggc tttggcatct atttattctc 1320
ctgaccatac cagcagtagt tttccgtcaa atccatcaac accagttgga tcaccttcac 1380
ctctcacagg taccagtcag tggccaagac ctggagggca agcaccttca tccccaagct 1440
atgaaaactc actccactcc ctgaaaaatc gagttgagca gcaacttcac gagcatttgc 1500
aagatgcaat gtccttctta aaggatgtct gtgagcagtc tcgaatggag gatcgtttag 1560
acagactgga tgatgcaatc catgtgctgc ggaaccatgc tgtgggacct tccaccagtt 1620
tgcctgctgg tcacagtgat atacatagtt tattgggacc atcccataat gcaccaattg 1680
gaagcctcaa ttcaaactat ggaggatcaa gccttgttgc aagcagtcga tcagcttcaa 1740
tggttggaac tcatcgggaa gactctgtca gtctcaatgg caatcattca gtcctgtcta 1800
gtacagtcac tacttcaagc acagacctga accataaaac acaagaaaat tatagaggtg 1860
gcttgcaaag tcagtctgga actgttgtta caacagaaat caagactgaa aacaaagaaa 1920
aggatgaaaa ccttcatgaa cctccttcat cagatgacat gaagtcagat gatgaatcct 1980
cccaaaaaga tatcaaggtt tcatctagag gcagaacaag cagtactaat gaagatgagg 2040
atttgaaccc tgaacagaag atagaaaggg agaaggagag gcggatggct aacaatgcca 2100
gagaacgctt acgcgtgcgg gatattaatg aagcattcaa agagcttggc cgaatgtgtc 2160
agcttcactt gaagagtgaa aaaccccaaa caaaactcct tattcttcat caagccgtgg 2220
cagtcatcct tagtctagaa cagcaagtca gagagaggaa ccttaacccc aaagcagcct 2280
gccttaagag aagggaagaa gaaaaagttt ctgccgtatc ggcagagccg ccaaccacac 2340
tgccaggaac ccatcctggg cttagtgaaa ctaccaaccc tatgggtcat atgtaaacat 2400
cagccagttc cagagttatc agtaggctag atagaaggtg acctctcctc ataaggactt 2460
ggacaactca gattatctga agacacaaac ctgacaggag ggagaagaaa aaacaaaaca 2520
cttgaaccaa gaaactcaaa tgtaatccta cgatcaaagc aactggtcaa cacttccatc 2580
agaagtgaag ataggaagct catcagatag aacatcagcc catgagatgt ttgcaacaaa 2640
tcttttgttg caagcagtgt gtcgcttctg cacaatcaga gactgtctcg atctctccac 2700
tcaccgtgga agttgccttg tgcctaaact gaattgacaa atgcattgta actacaaatt 2760
ttatttattg ttatgaaact gtaaggtcta catataaagg gaaaaagtta atgtggaaag 2820
ctgatctaca ctcagctgat gccagcatac attaaagcgg ttcacgtgca gagaacaaag 2880
cagtgacaac cattggccct tagcattccc ggcataccta ttagtgtctt aaaaaggaag 2940
ggaaaagtct tttgttgccc tctcctatcc tcttgccata tgaatagcgt tttccatgaa 3000
ataggaaaat attacttggt atagcatttc tcttgctctc attttttgat ttatttttat 3060
tttctctttg tgggtgttat atttgatctc taaatctgaa cagtttatgg tcacagtcca 3120
gcctcctccg tgcagccctg tgtgctttgc acatttacct tacagtggta agcagagacc 3180
atctgtgacc atagcctagc tagcatttta aaaggggaaa ttttgttctc taggttttcc 3240
cccaaataaa cattgcttta tttctaataa taaccaagac ttttcaagct tctagatctc 3300
ataggaaagc ttgtaatagc aaaattgtaa attacaaggg aagaatctac tttttagaaa 3360
tcgctttgtt ttccaagcag taagtactac atacagtact tgtaaagtgt tagctgtaag 3420
taagcacaaa atacatttaa aatacaaaga cgattttttc aggctgtgat tatggtgaac 3480
ataacaaaac ccagtagtca ccaaggcagg tagtgtgata aatgaacaca ccactctgag 3540
gctaattacc taatggaata caagagcaat ggtcacccgt atttccttat cctagccttt 3600
atttctctgt catttggatg gctggtcaat ggggaagaat tgagtgggtg atttaatcaa 3660
ctgcaaacca tctgcccctg tcccaaaatg atgagccaga ttagcattaa accagtactt 3720
gtcagtccat cttaatactg ttcattaagg cactctctgt ctctaatcct taggagttgt 3780
tttaaaagac ataatcactt tgaacttcca tgaaacctgt cttccaccac aacaaccctg 3840
ggagagaaaa acatgctaaa ggaggtatct tggcttaata attccttata gccaatatca 3900
acagtggcaa tcagcacaca gaggaaagga cccaaatcac tatgtagctt aaagatttct 3960
gttaatttga aagaacaaaa acaagacaga acttctggta ctctaatcag gatgattcct 4020
aacaagtcag tcatttgtga acttagtgga ctttttggtt actttaattt gcatatattc 4080
tccagttaca tcggactcta tctgtggcct tgttcttcat ttcagtgtta atcagctaaa 4140
cagaagttgt tgcttatgat gtgtgagtga acatatgcca ctgcctggcc tttttttctt 4200
cagagcttgt tgtctttttc gctatattag actttgcagt atgcccagaa gctttccttc 4260
ataaaataga aagaaaaaaa catttggctt atttttcact gtagctagtc ttttatacaa 4320
taatcttgta agaaaatttc ttgaattcta aatattactc tttctagatt tttgaaatca 4380
aaaagttttc agtaaaaagt ttcttacttt attttattat attaggtagt aaaaaatgta 4440
gggttattta ccataacctg ttcattaata tcagaaattt acaatagcat tttaagacca 4500
tagtaggatt ctagcatacc gtgtagtacc tatggagtat tgtaagagct aattgttgga 4560
gatgaattgc ttctcatctt gttctccagt ttccattgtt ggtttattgc agatttgtat 4620
cctgtgtcaa attcaaggta ttattgataa accttttcaa ccagcagcaa gaagttcaaa 4680
tttttttctg tcactgtaac agaaaacaca atatgtatat aacatttatg tagcaataaa 4740
tgtgccatct tttttttaac acagtaaaat agtgagtttt ttacatttct ctttctcaaa 4800
taataatgta ttttgtttta ttttctccat ctcattcgtc ccagaaacac tcacactgct 4860
tttcctaact gcattaccga cattatctgg gaaacccttc aggacagaat caggcttgtg 4920
gagctaagtt ggcaatctgg tctagagctt ctctagcttg tgcttttctc ctcttgccct 4980
cactactgac ggtggccttt taaccttttc ctaaagattg accaaacagc aactagtagt 5040
tatagaaaat ctactcattt gtagatacag agaaaaatga agaagatgga aaaagactca 5100
aaagaggctt tttaagttat tcttcaaagc acttttcaca tttccccata ccctttctca 5160
caaaaaaagt gtcataatta agtaatggta ttgtttactg tttaaaagtt aaaagatcaa 5220
aaatttgctt ttatcccagt ttttaaccac aaaaaaaagc gtagggatta tccatgagga 5280
cttcatgcca agcaagaacc tcaaacaaac tagacaaact ttttttttga cagtgaatga 5340
ctttttgtag gacctgtgcg tgcgaaaccc atggcaattg tcacatcctc ttggtatgct 5400
ggcagattgc ttctcttggt gaattatgaa atccactgtt cacattgggt gcctaacaga 5460
acattttgct tcttgtggga tttagtgaaa actattaaac ttgttaagtt gattttatac 5520
aaaacgataa ataaaaagct ctaagaagaa aatgtataat cttagagctg aaataaaata 5580
tagagaccat ctagtaaatg acctcattaa tatatctgtg aaaactgaga ctcagattgt 5640
atgtctctaa gaacacataa ttagtaacag atcaagacac ttaaaacttt ccctacaaaa 5700
cctccctgcc ttgactttct ctttctcttt gcagatttct aggccgcttc tgctcagtgt 5760
cttcattttc ttccatattt gttttatttc atttttcttt tctatagttc atgttttctt 5820
tttccttgga aactcaaaat ttaaacacac gtcgtgtgtg tgtgtgtgtg tgtgtctgtg 5880
tgtgtgtgac ttaaagaatc ttaagctttg gcattaaata gtcctcgatt caaatctaag 5940
ctcaacatct gattaacttc attttcctat ctgaaaaatg gagataacat tagaattgtg 6000
taagtattga atgaaacaat gtatggaaag ctcttatggt tcttgtcacc taagaagtac 6060
ttaataaatg ataaatattt ttaaataaat aatattataa ccaa 6104
<210> 44
<211> 4707
<212> DNA
<213> 小家鼠
<400> 44
ggaaaaaaaa aaaaatgtcc gcctgaggag acccacaagt tctatcgggg ggacagccag 60
cccgcccggg gagccacggg cggctaagcc cgagagccgc ccgagtcgcg ccgactcaag 120
cactcgcggg ggcccgaggc aacgcagccg ccggcggcgc gtggggaggg ggaaagcctg 180
agcccgcgct cccggccaaa gtgaacttta atcgggaagg ttggatgcgg agcccgggcg 240
gcaggacctg ctagaagtgg ctgaagatga atccccagca gcagcgcatg gccgcgatag 300
ggaccgacaa ggagctgagc gacctgctgg acttcagtgc gatgttttct ccacctgtta 360
atagtgggaa aacgagacca acaacactgg gaagtagtca gttcagcggg tcaggtatgg 420
atgagcgtgg aggaacaaca tcttggggaa caagtggtca accaagcccc tcctatgatt 480
catctagagg ttttacagac agccctcatt acagtgatca cttgaatgac agtcgattag 540
gaacccacga aggcttgtcc ccaacacctt tcatgaactc aaatctgata gggaaaacat 600
cagagagagg ctcattttcc ctgtacagca gagactctgg actctcaggc tgtcagtcta 660
gtctcctgag acaagatcta ggacttggga gcccggcaca gctgtcttct tcaggaaagc 720
ctggaacacc atactactca ttctctgcca caagttcgag aagaagaccg ctccatgatt 780
ctgtagccct agatccttta caagcgaaga aagtaagaaa ggtgcctcct ggcctacctt 840
cttctgtata tgcaccatcc ccaaattctg acgatttcaa ccgtgaatct cctagttacc 900
catctcccaa gccaccaacc agtatgttcg ctagcacttt ctttatgcaa gatgggaccc 960
acagttcttc tgacctttgg agttcatcga atgggatgag ccagcctggt tttggtggaa 1020
ttctggggac ctccacatcc cacatgtctc agtccagtag ttatggcagc cttcattcac 1080
atgaccgctt gagttatcct ccacactcag tgtcaccaac agacataaac acaagtcttc 1140
cgccaatgtc cagcttccac cgtggtagta ccagcagctc accatatgtt gccgcctcac 1200
atactcctcc catcaatgga tcagatagca tcctaggaac cagagggaat gctgctggaa 1260
gctcacagac gggtgatgca cttgggaagg ccttggcatc tatttattcc cctgaccaca 1320
caagcagtag ttttccatca aacccatcaa caccagtggg atctccttca cctctcacag 1380
gtaccagtca gtggcccaga gctggagggc aagctccttc atctccaagc tatgaaaact 1440
cacttcactc cctgaaaaat cgagttgagc agcaacttca cgagcatttg caagatgcaa 1500
tgtccttctt aaaggatgtc tgtgagcagt ctcgaatgga agaccgctta gacaggctgg 1560
atgatgctat ccatgtgcta cgaaaccatg cagttggacc ttctaccagt ctgcctacta 1620
gccacagtga catacacagt ttgctgggac catcccataa tgcatcaatt ggaaacctca 1680
attcaaacta tggaggatcc agccttgtta caaatagtcg atcagcttcg atggtcggaa 1740
cacatcggga agattcagtc agtctcaatg gcaatcattc ggtcctgtct agtactgttg 1800
ctgcctcaaa cacagaactg aaccataaaa caccagaaaa tttcagaggt ggtgtacaaa 1860
atcagtctgg aagtgttgtt ccaacagaaa tcaagactga aaacaaagaa aaagatgaaa 1920
accttcatga acctccttca tcagatgaca tgaaatcaga tgatgagtcc tcccagaaag 1980
acatcaaggt ctcatctagg ggcagaacaa gcagtaccaa tgaagacgag gatctgaatc 2040
cagaacagaa aatcgaaagg gagaaggaaa ggcggatggc taacaatgcc agagagcgcc 2100
tgcgcgtgcg ggatattaac gaggcgttca aggagcttgg ccgaatgtgt cagcttcatt 2160
tgaagagtga aaaacctcag acaaaacttc tcattcttca tcaggccgtg gcagtcatcc 2220
ttagtctaga acagcaagtg agagagagga acctcaaccc caaagcagcc tgccttaaga 2280
gaagagaaga agaaaaagtc tctgctgcgt cagcagagcc gcccaacacg ttgccaggag 2340
cccatcctgg gcttagtgag tctaccaacc ctatgggtca tctgtaaaca tcagccagtt 2400
ccagagtcat cagtaggcta aatagaaggt gacctctcct cataagattt ggacaactca 2460
gattatctga agacacaaac ctggcaggag ggagaagaaa aagcaaaaca cttgaaacca 2520
gaaactcata tgtaatcctg tgatcaaagc aactggtcag cacttcatca gacgtgagca 2580
taggaagctc agcagagacc gtcggccgtg aggtgtttgc agcatatcac tctgctgtaa 2640
tcagtgtgtc gcttctgcac aatcagagac tgtctcatct ctccactcaa cgtggaagtt 2700
gccttgtgcc taaactgaat tgacaaatgc attgtaacta caaattttat ttattgttat 2760
ggaactgtga ggtctacata taaagggaaa agttcatgtg ggaagctgat gtacactcag 2820
ctgatgccag cattgttaaa gctgttcaca gagcagtggc aaccattggc ccttagcatt 2880
cccggcatac ctgttagtgt cttaaaaagg aagggagtcc tttgttgccc tctccgacct 2940
tcgccatatg aatagtgatt tccatgaaat aggaaaaata ttacttcgta tagcatttct 3000
ctcttgtttt tttcactcat ttttatttcc tctttgtggg tgttatattt gatctgagtc 3060
tgcatagttt atggtcacag tccagaaccc tccttgcagt cctgtatgct ttgttcatgt 3120
ccttgaagtg ataagcagac accatctgtg accatagcct agctaatatt ttgaaagggg 3180
aagttttgtc ccctggattt gcccccaaat aaacattgct ttatttctaa taatcactaa 3240
gacttttcag gcttctaggt ttcatagtaa agctataata gcaagaagtg taacttacaa 3300
gggagagttt actttttagg aattgctttg ttttccgagc agtaagtact acacaatata 3360
gtacttgtaa agtgttagct gataagtaag cacagaatgc attcagtaca atacaaagat 3420
gacttttcct ggtgagtctc cgggacaggc agtgtgatga atgcactcaa ccgctctgag 3480
gctaattacc tatggaatcc aagagcaatg gtcacggttc cttaccctag ctttacttct 3540
gtcctttgag ttggctggtc cgtggggggt ggggcaggag ggtgacttaa tcacctgcaa 3600
accacctgcc cccaccccaa gaagagccag attagcaccg agctgtacct gtcagtctgt 3660
cttagcatta tgcattaagg caccctctgt ctctaatccc ttacagttgt ttttaagaca 3720
cagtaatcac tttaaacttc catgaaatct gtcttccacc acagcaccct gggagagaaa 3780
aacatgctaa gcgtgatggt cttggctaag taactcctta aagccaatag cagtggcagt 3840
ctgcacagaa gaaaaatccc aagtcgttct gtaacttaga gacaccggag aattttgaaa 3900
gaacaaaaac catgaagaca gcacttcaga tcctccatca ggactctggt gaacacgtca 3960
gtctttggcg aacttagtgg acttaatttg tatatgttct ccagttagat cagactctat 4020
ctgtggcctt gttcttcatt tcagtgttaa tcagctaaaa cagcagttgt tgctatgatg 4080
tgtgagtgaa cataagccac tgcctggcct tttttcttca gagcttgtcg tctttttcgc 4140
tatattagac tttgcagtat gcccagaagc tttccttcat aaaatagaaa gaaaaaaaca 4200
tttggcttat ttttcactgt agctagtctt ttatacaata atcttgtaag aaaatttctt 4260
gaattctaaa tattactctt tctagatttt tgaaatcaaa agttttcagt aaaaagtttc 4320
ttactttatt ttattatatt aggtagttaa agaaaatgta gggttattta ccataacctg 4380
ttcattaata tcagaaattt acaatagcat tttaagagca tagtaggttc tagcatacca 4440
tgtagttcct atggagtatt gtgagagcga attgttggag atgagctgct tttcatcttg 4500
ttctccagtt tccattgttg gtttattgca gatttgtatt ctgtgtcaaa ttcaaggtat 4560
tattgataaa ccttttcaac cagcagcaag aagttcaaat ttcttttttc tgtcgctgta 4620
acagaaaaca cagtatgtat ataacattta tgtagcaata aatgtgccat cctttttttt 4680
aacatagtaa actagtgagt tttttac 4707
<210> 45
<211> 4116
<212> DNA
<213> 智人
<400> 45
gtttcgcttt cctgcgcaga gtctgcggag gggctcggct gcaccggggg gatcgcgcct 60
ggcagacccc agaccgagca gaggcgaccc agcgcgctcg ggagaggctg caccgccgcg 120
cccccgccta gcccttccgg atcctgcgcg cagaaaagtt tcatttgctg tatgccatcc 180
tcgagagctg tctaggttaa cgttcgcact ctgtgtatat aacctcgaca gtcttggcac 240
ctaacgtgct gtgcgtagct gctcctttgg ttgaatcccc aggcccttgt tggggcacaa 300
ggtggcagga tgtctcagtg gtacgaactt cagcagcttg actcaaaatt cctggagcag 360
gttcaccagc tttatgatga cagttttccc atggaaatca gacagtacct ggcacagtgg 420
ttagaaaagc aagactggga gcacgctgcc aatgatgttt catttgccac catccgtttt 480
catgacctcc tgtcacagct ggatgatcaa tatagtcgct tttctttgga gaataacttc 540
ttgctacagc ataacataag gaaaagcaag cgtaatcttc aggataattt tcaggaagac 600
ccaatccaga tgtctatgat catttacagc tgtctgaagg aagaaaggaa aattctggaa 660
aacgcccaga gatttaatca ggctcagtcg gggaatattc agagcacagt gatgttagac 720
aaacagaaag agcttgacag taaagtcaga aatgtgaagg acaaggttat gtgtatagag 780
catgaaatca agagcctgga agatttacaa gatgaatatg acttcaaatg caaaaccttg 840
cagaacagag aacacgagac caatggtgtg gcaaagagtg atcagaaaca agaacagctg 900
ttactcaaga agatgtattt aatgcttgac aataagagaa aggaagtagt tcacaaaata 960
atagagttgc tgaatgtcac tgaacttacc cagaatgccc tgattaatga tgaactagtg 1020
gagtggaagc ggagacagca gagcgcctgt attggggggc cgcccaatgc ttgcttggat 1080
cagctgcaga actggttcac tatagttgcg gagagtctgc agcaagttcg gcagcagctt 1140
aaaaagttgg aggaattgga acagaaatac acctacgaac atgaccctat cacaaaaaac 1200
aaacaagtgt tatgggaccg caccttcagt cttttccagc agctcattca gagctcgttt 1260
gtggtggaaa gacagccctg catgccaacg caccctcaga ggccgctggt cttgaagaca 1320
ggggtccagt tcactgtgaa gttgagactg ttggtgaaat tgcaagagct gaattataat 1380
ttgaaagtca aagtcttatt tgataaagat gtgaatgaga gaaatacagt aaaaggattt 1440
aggaagttca acattttggg cacgcacaca aaagtgatga acatggagga gtccaccaat 1500
ggcagtctgg cggctgaatt tcggcacctg caattgaaag aacagaaaaa tgctggcacc 1560
agaacgaatg agggtcctct catcgttact gaagagcttc actcccttag ttttgaaacc 1620
caattgtgcc agcctggttt ggtaattgac ctcgagacga cctctctgcc cgttgtggtg 1680
atctccaacg tcagccagct cccgagcggt tgggcctcca tcctttggta caacatgctg 1740
gtggcggaac ccaggaatct gtccttcttc ctgactccac catgtgcacg atgggctcag 1800
ctttcagaag tgctgagttg gcagttttct tctgtcacca aaagaggtct caatgtggac 1860
cagctgaaca tgttgggaga gaagcttctt ggtcctaacg ccagccccga tggtctcatt 1920
ccgtggacga ggttttgtaa ggaaaatata aatgataaaa attttccctt ctggctttgg 1980
attgaaagca tcctagaact cattaaaaaa cacctgctcc ctctctggaa tgatgggtgc 2040
atcatgggct tcatcagcaa ggagcgagag cgtgccctgt tgaaggacca gcagccgggg 2100
accttcctgc tgcggttcag tgagagctcc cgggaagggg ccatcacatt cacatgggtg 2160
gagcggtccc agaacggagg cgaacctgac ttccatgcgg ttgaacccta cacgaagaaa 2220
gaactttctg ctgttacttt ccctgacatc attcgcaatt acaaagtcat ggctgctgag 2280
aatattcctg agaatcccct gaagtatctg tatccaaata ttgacaaaga ccatgccttt 2340
ggaaagtatt actccaggcc aaaggaagca ccagagccaa tggaacttga tggccctaaa 2400
ggaactggat atatcaagac tgagttgatt tctgtgtctg aagttcaccc ttctagactt 2460
cagaccacag acaacctgct ccccatgtct cctgaggagt ttgacgaggt gtctcggata 2520
gtgggctctg tagaattcga cagtatgatg aacacagtat agagcatgaa tttttttcat 2580
cttctctggc gacagttttc cttctcatct gtgattccct cctgctactc tgttccttca 2640
catcctgtgt ttctagggaa atgaaagaaa ggccagcaaa ttcgctgcaa cctgttgata 2700
gcaagtgaat ttttctctaa ctcagaaaca tcagttactc tgaagggcat catgcatctt 2760
actgaaggta aaattgaaag gcattctctg aagagtgggt ttcacaagtg aaaaacatcc 2820
agatacaccc aaagtatcag gacgagaatg agggtccttt gggaaaggag aagttaagca 2880
acatctagca aatgttatgc ataaagtcag tgcccaactg ttataggttg ttggataaat 2940
cagtggttat ttagggaact gcttgacgta ggaacggtaa atttctgtgg gagaattctt 3000
acatgttttc tttgctttaa gtgtaactgg cagttttcca ttggtttacc tgtgaaatag 3060
ttcaaagcca agtttatata caattatatc agtcctcttt caaaggtagc catcatggat 3120
ctggtagggg gaaaatgtgt attttattac atctttcaca ttggctattt aaagacaaag 3180
acaaattctg tttcttgaga agagaatatt agctttactg tttgttatgg cttaatgaca 3240
ctagctaata tcaatagaag gatgtacatt tccaaattca caagttgtgt ttgatatcca 3300
aagctgaata cattctgctt tcatcttggt cacatacaat tatttttaca gttctcccaa 3360
gggagttagg ctattcacaa ccactcattc aaaagttgaa attaaccata gatgtagata 3420
aactcagaaa tttaattcat gtttcttaaa tgggctactt tgtccttttt gttattaggg 3480
tggtatttag tctattagcc acaaaattgg gaaaggagta gaaaaagcag taactgacaa 3540
cttgaataat acaccagaga taatatgaga atcagatcat ttcaaaactc atttcctatg 3600
taactgcatt gagaactgca tatgtttcgc tgatatatgt gtttttcaca tttgcgaatg 3660
gttccattct ctctcctgta ctttttccag acactttttt gagtggatga tgtttcgtga 3720
agtatactgt atttttacct ttttccttcc ttatcactga cacaaaaagt agattaagag 3780
atgggtttga caaggttctt cccttttaca tactgctgtc tatgtggctg tatcttgttt 3840
ttccactact gctaccacaa ctatattatc atgcaaatgc tgtattcttc tttggtggag 3900
ataaagattt cttgagtttt gttttaaaat taaagctaaa gtatctgtat tgcattaaat 3960
ataatatgca cacagtgctt tccgtggcac tgcatacaat ctgaggcctc ctctctcagt 4020
ttttatatag atggcgagaa cctaagtttc agttgatttt acaattgaaa tgactaaaaa 4080
acaaagaaga caacattaaa acaatattgt ttctaa 4116
<210> 46
<211> 5150
<212> DNA
<213> 小家鼠
<400> 46
aggtgcggat ccgggtgcgg gtgcgggtgg aagtggggcg ccctctcctc ggacctgggg 60
tctgctgccc acaggtgacc tgtcatcccg cagagagaac gccaggagcc ggatcgcttg 120
cccaactctt ggcgctgctt ggctctctta tcctgccgtt ctcacttcta ggtcgtttca 180
gctctgctcc ataccctgag ccggcgccac gccgccgcgc atgcaactgg catataactt 240
gctgtgtgtg gtgattgctt gtgttgaatc ccgaacctgc acccggagac agcccaagga 300
tgtcacagtg gttcgagctt cagcagctgg actccaagtt cctggagcag gtccaccagc 360
tgtacgatga cagtttcccc atggaaatca gacagtacct ggcccagtgg ctggaaaagc 420
aagactggga gcacgctgcc tatgatgtct cgtttgcgac catccgcttc catgacctcc 480
tctcacagct ggacgaccag tacagccgct tttctctgga gaataatttc ttgttgcagc 540
acaacatacg gaaaagcaag cgtaatctcc aggataactt ccaagaagat cccgtacaga 600
tgtccatgat catctacaac tgtctgaagg aagaaaggaa gattttggaa aatgcccaaa 660
gatttaatca ggcccaggag ggaaatattc agaacactgt gatgttagat aaacagaagg 720
agctggacag taaagtcaga aatgtgaagg atcaagtcat gtgcatagag caggaaatca 780
agaccctaga agaattacaa gatgaatatg actttaaatg caaaacctct cagaacagag 840
aaggtgaagc caatggtgtg gcgaagagcg accaaaaaca ggaacagctg ctgctccaca 900
agatgttttt aatgcttgac aataagagaa aggagataat tcacaaaatc agagagttgc 960
tgaattccat cgagctcact cagaacactc tgattaatga cgagctcgtg gagtggaagc 1020
gaaggcagca gagcgcctgc atcgggggac cgcccaacgc ctgcctggat cagctgcaaa 1080
gctggttcac cattgttgca gagaccctgc agcagatccg tcagcagctt aaaaagctgg 1140
aggagttgga acagaaattc acctatgagc ccgaccctat tacaaaaaac aagcaggtgt 1200
tgtcagatcg aaccttcctc ctcttccagc agctcattca gagctccttc gtggtagaac 1260
gacagccgtg catgcccact cacccgcaga ggcccctggt cttgaagact ggggtacagt 1320
tcactgtcaa gctgagactg ttggtgaaat tgcaagagct gaactataac ttgaaagtga 1380
aagtctcatt tgacaaagat gtgaacgaga aaaacacagt taaaggattt cggaagttca 1440
acatcttggg tacgcacaca aaagtgatga acatggaaga atccaccaac ggaagtctgg 1500
cagctgagtt ccgacacctg caactgaagg aacagaaaaa cgctgggaac agaactaatg 1560
aggggcctct cattgtcacc gaagaacttc actctcttag ctttgaaacc cagttgtgcc 1620
agccaggctt ggtgattgac ctggaggtct ttgttccctt tcagaccacc tctcttcctg 1680
tcgtggtgat ctccaacgtc agccagctcc ccagtggctg ggcgtctatc ctgtggtaca 1740
acatgctggt gacagagccc aggaatctct ccttcttcct gaaccccccg tgcgcgtggt 1800
ggtcccagct ctcagaggtg ttgagttggc agttttcatc agtcaccaag agaggtctga 1860
acgcagacca gctgagcatg ctgggagaga agctgctggg ccctaatgct ggccctgatg 1920
gtcttattcc atggacaagg ttttgtaagg aaaatattaa tgataaaaat ttctccttct 1980
ggccttggat tgacaccatc ctagagctca ttaagaagca cctgctgtgc ctctggaatg 2040
atgggtgcat tatgggcttc atcagcaagg agcgagaacg cgctctgctc aaggaccagc 2100
agccagggac gttcctgctt agattcagtg agagctcccg ggaaggggcc atcacattca 2160
catgggtgga acggtcccag aacggaggtg aacctgactt ccatgccgtg gagccctaca 2220
cgaaaaaaga actttcagct gttactttcc cagatattat tcgcaactac aaagtcatgg 2280
ctgccgagaa cataccagag aatcccctga agtatctgta ccccaatatt gacaaagacc 2340
acgcctttgg gaagtattat tccagaccaa aggaagcacc agaaccgatg gagcttgacg 2400
accctaagcg aactggatac atcaagactg agttgatttc tgtgtctgaa gtccaccctt 2460
ctagacttca gaccacagac aacctgcttc ccatgtctcc agaggagttt gatgagatgt 2520
cccggatagt gggccccgaa tttgacagta tgatgagcac agtataaaca cgaatttctc 2580
tctggcgaca tttttttccc atctgtgatt ccttcctgct actgttcctt catatgcagt 2640
atttctaggg aaatgcaaga aagaaagagc atcacatttg ctgagcactg ctggtagaaa 2700
gtggatattt ctctaattag aaacctgtta ctctgaagga cttcatgcat cttactgaag 2760
gtgaaatgga aagtcactta acacaaaatg gattttgtaa acaaagacca agagatccac 2820
ccaagcacca ggactagagt gcgagtattt ggggcaaggt gaggagaacg gtcactttag 2880
taatggtctg taatcagtgc ccaagtgctg cacatcactg gaaagagaca tacttatggg 2940
ggaggggcct tcttgatgga ggaatgtttc tgtcccggga gacattggca cttcccctct 3000
cctggatggc cggaagtctt ccactgtttt acatatggca cagttcaaag tcaactttag 3060
atccaatgct ctatcaaact atagtgggca tccttcatgt gagtgggaag aaaacaaccg 3120
tgctccttac tgcagcttct gccaaggcat ggttgctctc ctcagggact agctttgttg 3180
gtggcaatgg ctacacaaaa ctaaacacca acagaagtaa gaccattttc atgagtactc 3240
catcaagtta aagggttttt gttgtctttt tggtcatgga ttgaataaaa ttgtctttgc 3300
acatccatta agggggccag ctttcttaaa gcaatttttc ttttttttta actaaaatta 3360
gatataggtg aactcatgtt ttttagtggg ctgaacttat cggttttagc tggttgtctt 3420
aattagccat aaacttggag aaagcagtga cttcttgaat ccttagccaa atatgagtat 3480
cagataattt tattattttt ttttcgagac agggtttctc tgtgtagccc tggctattct 3540
ggaactcact ctgtagatca ggctggcctg gaactcagaa atccgcctgt ctctgcctcc 3600
cgagtgctgg gattaaaggt gtgcaccacc aatgcctggt gagataactt taaagaactc 3660
cctataaatg catgagaacc actgttactg atgaatgtgg ttttttgaca actacattca 3720
caaatggcct gtcttgtgtt ttgtcaccgt tttgagggat gatgttttgt ggcacgtgtg 3780
tgatcacagc ctgatggttc tggtcgtggg ttggttcttc tgggccagct ttcacagact 3840
gctgcgcagc tgcacctaca gtgctgcccc ataatactgt ttcactttgg tgaagatcag 3900
cccaccttac accccgagtg caggtgtgaa ccacggtaag tgtgcacagt ccttagggaa 3960
aacagggacg cagaggcctg cctcctctct tttccatgcc aaaatgaaat gaccaagaaa 4020
caaaacattt aaaaagttgt ttctaaatgc tgagacctaa ccattgctta tatactgttg 4080
tctgttgaaa cagtttgtta caatttcatt ctgttgaact aggtgagact ttaagaaatg 4140
ttgaaattat gttaatttcc tattattatt taatataaag atatttaaaa tgtctagtgt 4200
tatgagttgg tttaatatat atctcatgta tgtatcagtc ctattttaag cgctttttaa 4260
aaaagacttg tttaggtata tattttatgt atatgggtgt tttatctgaa tgtatggaca 4320
ccagaagaga gcactgggtc ccatgagact acagtcaaat gggatcacag tcagatgcaa 4380
ttttgagctg ccatgtgggt gctgggattt gaactcaggg cctctggaag aacagccagt 4440
gcttttaact gctgaaccat ctcttgggac gcctatgggt cctattttaa aggaagaccg 4500
atatttccca agtgtcaccc ttgcttactc tactgcagac acaggaacta tggcagttta 4560
aggtaggtca gcgggcaggc ccagcggtga ggcctctctg aggtagaggc ctggggatca 4620
ggcgtttagt cattcaaggc cggcagggct ccatgggatc acatccaagt cagggcaaga 4680
catccactta cactttcagg tagctgcctg ttagacgtca ccaagcatgt cctagcttaa 4740
gtatgacgag gatggcattt tctaagtaca gagcatatat gtagcacttg ggataagctg 4800
atctagggac ttcctgaggc ggcagagctt aaagtggact ccattgactg cttggagact 4860
actgtggaat gaaggcatgt ctcagtaaac agaacaaacc tgtggcatct gtctgcctca 4920
gggaggcatc agacaaagct ggaaaggatt tagaaaattc ttttacctac tctgggagct 4980
gggaggctgt ccttcatccc gagggcatta tttatctgaa ggcatctttt gtttaagatt 5040
cattcatttg ttcctcaaat atgttcagtg cctgccttgc accaggcact attctagatg 5100
cgttgaaggc actaataaaa gaaatgcctc acagtaaaaa aaaaaaaaaa 5150
<210> 47
<211> 5961
<212> DNA
<213> 智人
<400> 47
aaagtgaatg gcgaaggact gaagggatcc ccccttcggg tccccggccg ccctgttcac 60
cctcgttcat cctcctttcc gaagctcgct ctcgaaggca ggagcgaccg gcgcctttgg 120
ctgaggagga ggagaaggag gaatcgcgcc aggcggagcg tcaggtcccg ttttcctctc 180
cggcgtctcc aatacaaaga ttacggtgca gaaggaaatt gcactcgtct cctccgcgcc 240
cccggtaccc aacacaatgc accagccgcc tgagtccacc gccgcggccg ccgccgctgc 300
agacattagc gctaggaaga tggcgcaccc ggcaatgttc cctcgaaggg gcagcggtag 360
tggcagcgcc tctgctctca atgcagcagg taccggcgtc ggtagtaatg ccacatcttc 420
cgaggatttt ccgcctccgt cgctgcttca gccgccgccc cctgcagcat cttctacgtc 480
gggaccacag cctccgcctc cacaaagcct gaacctcctt tcgcaggctc agctgcaggc 540
acagcctctt gcgccaggcg gaactcaaat gaaaaagaaa agtggcttcc agataactag 600
cgttactcct gctcagatct ccgctagtat cagctctaac aacagtatag cagaggacac 660
tgagagctat gatgatctgg atgaatctca cacggaagat ctctcttctt cggagatcct 720
tgatgtgtca ctttccaggg ctactgactt aggggagccc gaacgcagct cctcagaaga 780
gaccctaaat aacttccagg aagccgagac acctggggca gtctctccca accagcccca 840
ccttcctcag cctcatttgc ctcaccttcc acaacagaat gttgtgatca atgggaatgc 900
tcatccacac cacctccatc accaccatca gattcatcat gggcaccacc tccaacatgg 960
tcaccaccat ccatctcatg ttgctgtggc cagtgcatcc attactggtg ggccaccctc 1020
aagcccagta tctagaaaac tctctacaac tggaagctct gacagtatca caccagttgc 1080
accaacttct gctgtatcat ccagtggttc acctgcatct gtaatgacta atatgcgtgc 1140
tccaagtact acaggtggaa taggtataaa ttctgttact ggcactagta cagtaaataa 1200
tgttaacatt actgctgtgg gtagttttaa tcctaatgtg acaagcagca tgcttggtaa 1260
tgttaatata agtacaagca atattcctag tgctgctggt gtgagtgttg ggcctggagt 1320
taccagtggt gttaatgtga atatcttgag tggcatgggc aatggtacta tttcttcctc 1380
tgctgctgtt agcagtgttc ctaatgcagc tgcagggatg actgggggat cggtttcaag 1440
tcagcagcaa caaccaacag ttaacacttc gaggttcaga gttgtgaagt tagattctag 1500
ttctgagccc tttaaaaaag gtagatggac ttgcactgag ttctatgaaa aagaaaatgc 1560
tgtacctgct acagaaggtg tgctgataaa taaagtggtg gagactgtaa agcaaaatcc 1620
gatagaagtg acttctgaaa gggagagcac tagtgggagt tcagtgagca gtagtgtcag 1680
cacactgagt cactatacag agagtgtggg aagtggagag atgggagccc ctactgtggt 1740
ggtgcagcag cagcagcagc aacaacaaca acaacagcaa caaccagctc tccaaggtgt 1800
gaccctccaa cagatggatt ttggtagcac tggtccacag agtattccag cagttagtat 1860
accacagagt atttctcagt cacagatctc acaagtacaa ttacagtctc aagaactgag 1920
ctatcagcaa aagcaaggtc ttcagccagt acctctgcaa gccactatga gtgctgcaac 1980
tggtatccag ccatcgcctg taaatgtggt tggtgtaact tcagctttag gtcagcagcc 2040
ttccatttcc agtttggctc aaccccagct accatattct caggcggctc ctccagtgca 2100
aactcccctt ccaggggcac caccacccca acagttacag tatggacaac agcaaccaat 2160
ggtttctaca cagatggccc caggccatgt caaatcagtg actcaaaatc ctgcttcaga 2220
gtatgtacaa cagcagccaa ttcttcaaac agcaatgtcc tccggacagc ccagttctgc 2280
aggagtagga gcaggaacaa cagtgattcc tgtggctcag ccacagggta tccagctgcc 2340
agtgcagccc acagcagtcc cagcacaacc tgcaggggca tctgtccagc ctgttggcca 2400
ggctccggca gcagtgtctg ctgtacctac tggcagtcag attgcaaata ttggtcagca 2460
agcaaacata cctactgcag tgcagcagcc ctctacccag gttccacctt cagttattca 2520
gcagggtgct cctccatctt cgcaagtggt tccacctgct caaactggga ttattcatca 2580
gggagttcaa actagtgctc caagccttcc tcaacaattg gttattgcat cccaaagttc 2640
cttgttaact gtgcctcccc agccacaagg agtagaacca gtagctcaag gaattgtttc 2700
acagcagttg cctgcagtta gttctttgcc ctctgctagt agtatttctg ttacaagtca 2760
ggttagttca actggtcctt ctggaatgcc ttctgcccca acaaacttgg ttccaccaca 2820
aaatatagca caaacccctg ctacccaaaa tggtaatttg gttcaaagtg ttagtcaacc 2880
tcccttgata gcaactaata caaatttgcc tttggcacaa cagataccac taagttctac 2940
ccagttctcc gcacaatcat tagctcaggc aattggaagc caaattgaag atgccaggcg 3000
tgcagcggag ccctccttag ttggcttacc tcagactatc agtggtgaca gtgggggaat 3060
gtcagcagtt tcagatggga gtagcagcag cctagcagcc tctgcttctc ttttcccgtt 3120
gaaggtgcta ccgctgacga cacccctggt ggatggcgag gatgagagct cctctggtgc 3180
aagtgtggta gctattgaca acaaaatcga gcaagctatg gatctagtga aaagccattt 3240
gatgtatgcg gtcagagaag aagtggaggt cctcaaagag caaatcaaag aactaataga 3300
gaaaaattcc cagctggagc aggagaacaa tctgctgaag acactggcca gtcctgagca 3360
gcttgcccag tttcaggccc agctgcagac tggctccccc cctgccacca cccagccaca 3420
gggcaccaca cagccccccg cccagccagc atcgcagggc tcaggaccaa ccgcatagct 3480
gcctatgccc ccgcagaact ggctgctgcg tgtgaactga acagacggag aagatgtgct 3540
agggagaatc tgcctccaca gtcacccatt tcattgctcg ctgcgaaaga gacgtgagac 3600
tgacatatgc cattatctct tttccagtat taaacactca tatgcttatg gcttggagaa 3660
atttcttagt tgggtgaatt aaaggttaat ccgagaatta gcatggatat accgggacct 3720
catgcagctt ggcagatatc tgagaaatgg tttaattcat gctcaggagc tgtgtgcctt 3780
tccatccctt ccggctccct acccctcact tccaagggtt ctctctcctg cttgcgctta 3840
gtgtcctaca tggggttgtg aagcgatgga gctcctcact ggactcgcct ctctcctctc 3900
ctccccccag gaggaacttg aaaggagggt aaaaagacta aaatgagggg gaacagagtt 3960
cactgtacaa atttgacaac tgtcaccaaa attcataaaa aacaatagta ctgtgcctct 4020
ttcttctcaa acaatggatg acacaaaact atgagagtga caaaatggtg acaggtagct 4080
gggacctagg ctatcttacc atgaaggttg ttttgcttat tgtatatttg tgtatgtagt 4140
gtaactattt tgtacaatag aggactgtaa ctactattta ggttgtacag attgaaattt 4200
agttgtttca ttggctgtct gaggaggtgt ggacttttat atatagatct acataaaaac 4260
tgctacatga caaaaaccac acctaaagaa attttaagaa tttggcacag ttactcactt 4320
tgtgtaatct gaaatctagc tgctgaatac gctgaagtaa atccttgttc actgaagtct 4380
ttcaattgag ctggttgaat actttgaaaa atgctcagtt ctaactaatg aaatggattt 4440
cccagtaggg gtttctgcat atcacctgta tagtagttat atgcatatgt ttctgtgcat 4500
gttctctaca caattgtaag gtgtcactgt atttaactgt tgcacttgtc aactttcaat 4560
aaagcatata aatgttgata aacaagtgtt tttcatatga ccctgttaac ataatggcag 4620
tcatttccac aactgtttcc aggtaaagtt aacaatttga ctagtaaaat cctgaagggc 4680
agtggaatga ttggaaaagt aggggcgtga tttgactgca tgaagtaaaa ggaaattgac 4740
acattgagtt gttcagcagg taagagaaga gacagtggag gagtccagct caattctaac 4800
tactgtgtga cttggacagg ttgcttcact cctggacgga tgtaggggtt tgaaagagat 4860
gatctcttac attccccttt ggctttaaaa ttctaggagt ccttgaaaat cttaattttt 4920
tactgaactg agaggaagaa ggagccttat tctgtgtata attggaataa gcagatctag 4980
gatcaaaaga cggaagttgg agaagctgat ttccacttta agaaccctgt caccctgggt 5040
tgggatgttt ctcctagtgt aggatgagtt tctagctcct gggataattc gttttgtcta 5100
agcaaaagat gatttgaggt gggaccagat gagcaaggat gtccttgcag ttgattctgc 5160
atgactataa aacaggccaa aattaaaacc acgaaggaat cctgaggcag attggcccct 5220
ggcacctgag gagtgagcct gagggatccc actctgcagt aggagtaacg tgagcgagca 5280
agtgaatggg gtgggtttac cggctctgta atctatcaac ctagggcctc agcagtggcc 5340
ccctgcccag taggaattgg accaatccca agttctaagg cttgtcttaa gtccttgcag 5400
aacaaggaca aactttctga atcattcatt tctctcatct agagctggtg ggagattgag 5460
aggtgaatgg gacatccaag atccctaaaa agaattgttc gatagcgtgc atgtgttata 5520
aagtggtgac acgggcatcc tgttgaaatg atggatggct cactgccata ggctgatagc 5580
agttgtcata aagatatttt gggggaattt gaaaaggacg taaagaaaaa tctttcatat 5640
tggcttgttg gttatataac ttcaaattta ataaaggaat acttacgtag taattacatt 5700
tccttgaaaa aactatagtg aatagaaatc cctagccatt tcatttttta tgtttttaat 5760
gaagatcttt aaaataccat aggtggtaat cgtggaaaat ttgaaaaatc tcatgtcagt 5820
gtattaagat ggtggagaag tttttttctc cattatttaa tggaactttg ggtcttttta 5880
ttaaaaatgt gagactcatg aaattttggc agctgaatat ttgtgaaata agaatgaatt 5940
attaaaagat gtctttccat a 5961
<210> 48
<211> 4601
<212> DNA
<213> 小家鼠
<400> 48
ctggaggggg aagtgaatgg cgaaggactg aaggggtccc ccttcggttc cccagccacc 60
tggttcaccc ggttcatcct cccttcccga agttagccct cgaaggcacg agcagccggc 120
gccttcggca gaggaggagg aggaggaggg atcgcgtcgg gcggagcttc aggtcctgtt 180
cgtctctccg gcttctccat acaaagatta cggtgcagaa ggaaattgca cttgcctcct 240
ccgccccccg gtacccagca caatgcacca gccgccggag tccaccgccg cggcggccgc 300
tgctgcagac attagtgcta ggaagatggc gcacccggca atgttccctc gaaggggcag 360
cggtggtggc agcgcctctg ctctcaatgc agcaggtacg ggcgtcagtg gtgctgctcc 420
atcttctgaa gattttcctc ctccttcgct gctccagccg ccgcctcctg ctgcatcttc 480
cacgcaggga ccccagcctc cgcctccaca aagcctgaac ctcctctcgc aggctcagct 540
gcagggacag cctcttgcgc caggcggaac tcagatgaaa aagaaaagtg gcttccagat 600
aactagcgtt actccggctc agatctctgc cagcatcagc tccaacaaca gcatcgcgga 660
ggacaccgag agctacgacg atctggatga gtcgcacacg gaagatctct cctcttccga 720
gatcctcgac gtctcccttt ccagggccac tgacttaggt gagcctgaac gaagctcctc 780
agaggagact ctgaataact tccaggaagc tgagacacct ggggcagtct ctcctaacca 840
gccccacctt cctcagcctc atttgcctca ccttccacaa cagaacgttg tgatcaatgg 900
gaatgcccat ccccaccacc tccatcatca ccatcaccct catcatgggc accaccttca 960
ccatgggcac catcattcat cacatgctgc tgtggccggt ccatccattc ccggagggcc 1020
accctcgagc ccagtgtcca ggaaactctc tacaactgga agttctgatg gtggtgtgcc 1080
agtcgcacct cctcctgcag taccatcgag tggcttacca gcatcagtga tgacgaacat 1140
ccgtactcca agtactacag gaagcctagg tataaattcg gttactggca cgagcgctac 1200
gaataatgtt aacattgctg ctgtgggtag tttcagtccc agtgtgacga acagcgtgca 1260
tggtaatgct aatataaata caagcaatat ccctaatgct gctagcataa gtggtgggcc 1320
tggagttacc agtgttgtta attcgagtat cttgagtggc atgggcaatg gtaccgtttc 1380
ttcctctcct gttgctaaca gtgtccttaa tgcagctgca ggtatcactg tgggagtggt 1440
ttccagtcag cagcagcagc agcagcagca gcaaccaaca gttaacacat cgaggttcag 1500
ggttgtgaag ttagactcta cttctgaacc ctttaaaaaa ggtcgatgga cttgcacaga 1560
attctatgag aaggaaaacg ctgtgccagc tacagaaggc gtggccgtca ataaagtggt 1620
ggagacggtg aagcaaaccc ccacggaagc atcgtcctcg gagagggaga gcactagtgg 1680
gagttctgtg agcagtagtg tgagcacact gagtcactac acggagagtg tgggaagtgg 1740
agagatgatg ggagccccgg ctgtggtggc gccgcagcag ccgccgctac caccagcgcc 1800
tccaggtctt caaggtgtgg ctctccaaca gctagagttc agtagccctg ctccacagag 1860
tattgcggcg gttagtatgc cacagagtat ttctcagtca cagatgtcac aagtacagtt 1920
acagcctcaa gagttgagct ttcagcagaa gcagactctt cagcctgtcc ctctgcaagc 1980
caccatgagt gccgcaactg gtatccagcc ttcccctgtc agcgtggtcg gcatcacggc 2040
ggctgtaggt cagcagcctt ctgtttccag cctggctcaa ccgcagctgc catattctca 2100
gacagctcct cccgtgcaaa ctcctcttcc aggggcacca ccccagcagt tacaatatgg 2160
gcagcagcaa ccaatggttc ctgcgcagat agccccaggc catggccagc cagtgactca 2220
aaatccaact tcagagtatg tgcagcagca gcagcagcca atatttcaag cagcattgtc 2280
ctctgggcag tccagttcca cgggcacggg ggcaggaata tcagtgattc ctgtggctca 2340
ggcacagggg atccagctgc cagggcagcc cacagcagta caaacacaac ctgcaggggc 2400
ggctgggcag cccattggcc aggctcaaac agcagtgtcc actgtaccaa ctggcggtca 2460
gattgcaagt atcggtcaac aggcaaacat acccactgca gtacagcagc cctctaccca 2520
agttacacct tcagttattc agcaaggtgc tcctccatct tcacaagtag tcctacctgc 2580
tccaaccggg atcattcatc agggagttca aacccgtgct tcaagccttc cacaacaatt 2640
ggtcattgca ccccagagta ccttggtaac tgtgcctccc cagccacagg gagtagaaac 2700
cgtggcccaa ggggttgttt cccagcagtt gcccacaggc agtcctctgc cctctgctag 2760
cactatttct gttacaaatc aggttagttc agccgctcct tctggaatgc cttctgtccc 2820
aacaaactta gttccaccac agaatatagc acaaccccca gccacccaaa atggcagttt 2880
ggttcaaagt gttagtcaat ctcccttgat agccactaac ataaatttgc ctttggcaca 2940
acagatacca ctaagttcta ctcagttctc tacacaatca ttagctcagg ccattggaag 3000
ccaaatggaa gatgccaggc gcccagcgga gccctcctta ggcggcttac ctcagactat 3060
gagtggtgac agtgggggaa tgtcagcagt ttcagatggg agtagcagca gcctagcagc 3120
ccctgcttct ctcttcccgt tgaaggtgct accgctgaca acacccctgg tggatggcga 3180
ggacgagagc tctggtgcaa gtgtggtagc tatcgacaac aaaatagagc aagctatgga 3240
tctggtgaaa agccatttga tgtatgcggt gagggaggaa gtggaagttc tgaaggagca 3300
gatcaaagaa ctaatagaga aaaactccca gctggagcag gagaacaatc tgctgaagac 3360
gctggccagt ccggagcagc tcgcccagtt tcaggcccag ctgcagactg gctcccctcc 3420
ggccaccacg cagccacagg ggaccacaca gccccctgca cagccagcat cccagggctc 3480
aggatcaacc gcatagcctc ctaggcccca acagaactgg ctgctgctgc tgctgtctga 3540
actgaacaga ccgaagagat gtgctagaga gaagccgcct ccacagtcac ccatttcatt 3600
gctgtctacg aaagagacgt gagactcaca cgctgttctc gctttctccc cagtattaag 3660
cactcataag cttttggctt gaagaaatgt actagttgag tgaattaaag gttaatcaga 3720
gagtgagcag ggatgtgccc tgtgcaacgt ggcagatgtc tgaggaatgg tttaattgac 3780
cccgaggagc tctgtgcctt ttcaaccctc cccagccgcc caccctgctt ctgagagctc 3840
gggcggctcg ccttcgtggg gctcgcctgc gtggggttcg gaaagtgggc tgctcctgga 3900
ttctgcgctc tcttctcctt cccttcaaag aactcggaga ggccagaaac aagactgcaa 3960
tggggggcgg ggggagggat gatgcagtcc ttatacaaaa ccgacaactg tcaccaaagc 4020
ttataaaaca cgatagtact gtccctcttt tctgaaccat cagaagacac aaaactgtta 4080
gtgacacaac ggtgacaggt agctgggacc taggctatct tattatgaag gttgttttgc 4140
ttgttgtata tttgtgtatg tagtgtaacg aatttgtacc atagaggact gtccgtaact 4200
actgtttagc ttctacacat tgaaatgtag atgtttcatt ggctgtctga aaaggtgtgg 4260
cttgtccttc ctagagagat ctacttaaaa actgctttgt gacaaaaacc acacctgaag 4320
aaattttaag aatttggccc agttagtcac tctgtgtaat cccggaatct agctgctgaa 4380
gtcttgcgaa gtaaactccc cgtgaccgat gtcagttaag ctggtgatac ctggagaagt 4440
ggtcagttgc taaggaagtg gatttcccag taggggtttc tgcacctcac ctgtatagtc 4500
gttctgcgca tgtcccccac acagtcccca ctgtatttac ctgttctact tgtcaccttt 4560
caataaagca tatcaaatgt tgatacaaaa aaaaaaaaaa a 4601
<210> 49
<211> 436
<212> PRT
<213> 智人
<400> 49
Met Ala Gly Val Pro Glu Ser Leu Asn Leu Met Cys Asp Arg Asn Gly
1 5 10 15
Gly Arg Arg Leu Arg Gln Trp Leu Ile Glu Gln Ile Asp Ser Ser Met
20 25 30
Tyr Pro Gly Leu Ile Trp Glu Asn Glu Glu Lys Ser Met Phe Arg Ile
35 40 45
Pro Trp Lys His Ala Gly Lys Gln Asp Tyr Asn Gln Glu Val Asp Ala
50 55 60
Ser Ile Phe Lys Ala Trp Ala Val Phe Lys Gly Lys Phe Lys Glu Gly
65 70 75 80
Asp Lys Ala Glu Pro Ala Thr Trp Lys Thr Arg Leu Arg Cys Ala Leu
85 90 95
Asn Lys Ser Pro Asp Phe Glu Glu Val Thr Asp Arg Ser Gln Leu Asp
100 105 110
Ile Ser Glu Pro Tyr Lys Val Tyr Arg Ile Val Pro Glu Glu Glu Gln
115 120 125
Lys Cys Lys Leu Gly Val Ala Thr Ala Gly Cys Val Asn Glu Val Thr
130 135 140
Glu Met Glu Cys Gly Arg Ser Glu Ile Asp Glu Leu Ile Lys Glu Pro
145 150 155 160
Ser Val Asp Asp Tyr Met Gly Met Ile Lys Arg Ser Pro Ser Pro Pro
165 170 175
Glu Ala Cys Arg Ser Gln Leu Leu Pro Asp Trp Trp Ala Gln Gln Pro
180 185 190
Ser Thr Gly Val Pro Leu Val Thr Gly Tyr Thr Thr Tyr Asp Ala His
195 200 205
His Ser Ala Phe Ser Gln Met Val Ile Ser Phe Tyr Tyr Gly Gly Lys
210 215 220
Leu Val Gly Gln Ala Thr Thr Thr Cys Pro Glu Gly Cys Arg Leu Ser
225 230 235 240
Leu Ser Gln Pro Gly Leu Pro Gly Thr Lys Leu Tyr Gly Pro Glu Gly
245 250 255
Leu Glu Leu Val Arg Phe Pro Pro Ala Asp Ala Ile Pro Ser Glu Arg
260 265 270
Gln Arg Gln Val Thr Arg Lys Leu Phe Gly His Leu Glu Arg Gly Val
275 280 285
Leu Leu His Ser Ser Arg Gln Gly Val Phe Val Lys Arg Leu Cys Gln
290 295 300
Gly Arg Val Phe Cys Ser Gly Asn Ala Val Val Cys Lys Gly Arg Pro
305 310 315 320
Asn Lys Leu Glu Arg Asp Glu Val Val Gln Val Phe Asp Thr Ser Gln
325 330 335
Phe Phe Arg Glu Leu Gln Gln Phe Tyr Asn Ser Gln Gly Arg Leu Pro
340 345 350
Asp Gly Arg Val Val Leu Cys Phe Gly Glu Glu Phe Pro Asp Met Ala
355 360 365
Pro Leu Arg Ser Lys Leu Ile Leu Val Gln Ile Glu Gln Leu Tyr Val
370 375 380
Arg Gln Leu Ala Glu Glu Ala Gly Lys Ser Cys Gly Ala Gly Ser Val
385 390 395 400
Met Gln Ala Pro Glu Glu Pro Pro Pro Asp Gln Val Phe Arg Met Phe
405 410 415
Pro Asp Ile Cys Ala Ser His Gln Arg Ser Phe Phe Arg Glu Asn Gln
420 425 430
Gln Ile Thr Val
435
<210> 50
<211> 424
<212> PRT
<213> 小家鼠
<400> 50
Met Cys Asp Arg Asn Gly Gly Arg Arg Leu Arg Gln Trp Leu Ile Glu
1 5 10 15
Gln Ile Asp Ser Ser Met Tyr Pro Gly Leu Ile Trp Glu Asn Asp Glu
20 25 30
Lys Thr Met Phe Arg Ile Pro Trp Lys His Ala Gly Lys Gln Asp Tyr
35 40 45
Asn Gln Glu Val Asp Ala Ser Ile Phe Lys Ala Trp Ala Val Phe Lys
50 55 60
Gly Lys Phe Lys Glu Gly Asp Lys Ala Glu Pro Ala Thr Trp Lys Thr
65 70 75 80
Arg Leu Arg Cys Ala Leu Asn Lys Ser Pro Asp Phe Glu Glu Val Thr
85 90 95
Asp Arg Ser Gln Leu Asp Ile Ser Glu Pro Tyr Lys Val Tyr Arg Ile
100 105 110
Val Pro Glu Glu Glu Gln Lys Cys Lys Leu Gly Val Ala Pro Ala Gly
115 120 125
Cys Met Ser Glu Val Pro Glu Met Glu Cys Gly Arg Ser Glu Ile Glu
130 135 140
Glu Leu Ile Lys Glu Pro Ser Val Asp Glu Tyr Met Gly Met Thr Lys
145 150 155 160
Arg Ser Pro Ser Pro Pro Glu Ala Cys Arg Ser Gln Ile Leu Pro Asp
165 170 175
Trp Trp Val Gln Gln Pro Ser Ala Gly Leu Pro Leu Val Thr Gly Tyr
180 185 190
Ala Ala Tyr Asp Thr His His Ser Ala Phe Ser Gln Met Val Ile Ser
195 200 205
Phe Tyr Tyr Gly Gly Lys Leu Val Gly Gln Ala Thr Thr Thr Cys Leu
210 215 220
Glu Gly Cys Arg Leu Ser Leu Ser Gln Pro Gly Leu Pro Lys Leu Tyr
225 230 235 240
Gly Pro Asp Gly Leu Glu Pro Val Cys Phe Pro Thr Ala Asp Thr Ile
245 250 255
Pro Ser Glu Arg Gln Arg Gln Val Thr Arg Lys Leu Phe Gly His Leu
260 265 270
Glu Arg Gly Val Leu Leu His Ser Asn Arg Lys Gly Val Phe Val Lys
275 280 285
Arg Leu Cys Gln Gly Arg Val Phe Cys Ser Gly Asn Ala Val Val Cys
290 295 300
Lys Gly Arg Pro Asn Lys Leu Glu Arg Asp Glu Val Val Gln Val Phe
305 310 315 320
Asp Thr Asn Gln Phe Ile Arg Glu Leu Gln Gln Phe Tyr Ala Thr Gln
325 330 335
Ser Arg Leu Pro Asp Ser Arg Val Val Leu Cys Phe Gly Glu Glu Phe
340 345 350
Pro Asp Thr Val Pro Leu Arg Ser Lys Leu Ile Leu Val Gln Val Glu
355 360 365
Gln Leu Tyr Ala Arg Gln Leu Val Glu Glu Ala Gly Lys Ser Cys Gly
370 375 380
Ala Gly Ser Leu Met Pro Ala Leu Glu Glu Pro Gln Pro Asp Gln Ala
385 390 395 400
Phe Arg Met Phe Pro Asp Ile Cys Thr Ser His Gln Arg Pro Phe Phe
405 410 415
Arg Glu Asn Gln Gln Ile Thr Val
420
<210> 51
<211> 262
<212> PRT
<213> 智人
<400> 51
Met Leu Ala Leu Glu Ala Ala Gln Leu Asp Gly Pro His Phe Ser Cys
1 5 10 15
Leu Tyr Pro Asp Gly Val Phe Tyr Asp Leu Asp Ser Cys Lys His Ser
20 25 30
Ser Tyr Pro Asp Ser Glu Gly Ala Pro Asp Ser Leu Trp Asp Trp Thr
35 40 45
Val Ala Pro Pro Val Pro Ala Thr Pro Tyr Glu Ala Phe Asp Pro Ala
50 55 60
Ala Ala Ala Phe Ser His Pro Gln Ala Ala Gln Leu Cys Tyr Glu Pro
65 70 75 80
Pro Thr Tyr Ser Pro Ala Gly Asn Leu Glu Leu Ala Pro Ser Leu Glu
85 90 95
Ala Pro Gly Pro Gly Leu Pro Ala Tyr Pro Thr Glu Asn Phe Ala Ser
100 105 110
Gln Thr Leu Val Pro Pro Ala Tyr Ala Pro Tyr Pro Ser Pro Val Leu
115 120 125
Ser Glu Glu Glu Asp Leu Pro Leu Asp Ser Pro Ala Leu Glu Val Ser
130 135 140
Asp Ser Glu Ser Asp Glu Ala Leu Val Ala Gly Pro Glu Gly Lys Gly
145 150 155 160
Ser Glu Ala Gly Thr Arg Lys Lys Leu Arg Leu Tyr Gln Phe Leu Leu
165 170 175
Gly Leu Leu Thr Arg Gly Asp Met Arg Glu Cys Val Trp Trp Val Glu
180 185 190
Pro Gly Ala Gly Val Phe Gln Phe Ser Ser Lys His Lys Glu Leu Leu
195 200 205
Ala Arg Arg Trp Gly Gln Gln Lys Gly Asn Arg Lys Arg Met Thr Tyr
210 215 220
Gln Lys Leu Ala Arg Ala Leu Arg Asn Tyr Ala Lys Thr Gly Glu Ile
225 230 235 240
Arg Lys Val Lys Arg Lys Leu Thr Tyr Gln Phe Asp Ser Ala Leu Leu
245 250 255
Pro Ala Val Arg Arg Ala
260
<210> 52
<211> 267
<212> PRT
<213> 小家鼠
<400> 52
Met Leu Ala Leu Glu Ala Ala Gln Leu Asp Gly Pro His Leu Ser Cys
1 5 10 15
Leu Tyr Pro Glu Gly Val Phe Tyr Asp Leu Asp Ser Cys Lys Pro Phe
20 25 30
Ser Tyr Pro Asp Ser Asp Gly Gly Leu Asp Ser Thr Trp Gly Trp Thr
35 40 45
Glu Ala Pro Pro Ala Pro Ala Ile Ala Pro Tyr Glu Ala Phe Asp Pro
50 55 60
Ala Thr Ala Ala Phe Ser His Ser Gln Thr Val Gln Leu Cys Tyr Ser
65 70 75 80
His Gly Pro Asn Pro Ser Thr Tyr Ser Pro Met Gly Thr Leu Asp Pro
85 90 95
Ala Pro Ser Leu Glu Ala Pro Gly Pro Gly Leu Gln Val Tyr Pro Pro
100 105 110
Glu Asp Phe Thr Ser Gln Thr Leu Gly Ser Leu Ala Tyr Ala Pro Tyr
115 120 125
Pro Ser Pro Val Leu Ser Glu Glu Glu Asp Ile Met Leu Asp Ser Pro
130 135 140
Ala Leu Glu Val Ser Asp Ser Glu Ser Asp Glu Ala Leu Leu Ala Gly
145 150 155 160
Ser Glu Gly Arg Gly Ser Glu Ala Gly Ala Arg Lys Lys Leu Arg Leu
165 170 175
Tyr Gln Phe Leu Leu Gly Leu Leu Leu Arg Gly Asp Met Arg Glu Cys
180 185 190
Val Trp Trp Val Glu Pro Gly Ala Gly Val Phe Gln Phe Ser Ser Lys
195 200 205
His Lys Glu Leu Leu Ala Arg Arg Trp Gly Gln Gln Lys Gly Asn Arg
210 215 220
Lys Arg Met Thr Tyr Gln Lys Leu Ala Arg Ala Leu Arg Asn Tyr Ala
225 230 235 240
Lys Thr Gly Glu Ile Arg Lys Val Lys Arg Lys Leu Thr Tyr Gln Phe
245 250 255
Asp Ser Ala Leu Leu Pro Ala Ser Arg His Val
260 265
<210> 53
<211> 648
<212> PRT
<213> 智人
<400> 53
Met Ala Ala Pro Val Lys Gly Asn Arg Lys Gln Ser Thr Glu Gly Asp
1 5 10 15
Ala Leu Asp Pro Pro Ala Ser Pro Lys Pro Ala Gly Lys Gln Asn Gly
20 25 30
Ile Gln Asn Pro Ile Ser Leu Glu Asp Ser Pro Glu Ala Gly Gly Glu
35 40 45
Arg Glu Glu Glu Gln Glu Arg Glu Glu Glu Gln Ala Phe Leu Val Ser
50 55 60
Leu Tyr Lys Phe Met Lys Glu Arg His Thr Pro Ile Glu Arg Val Pro
65 70 75 80
His Leu Gly Phe Lys Gln Ile Asn Leu Trp Lys Ile Tyr Lys Ala Val
85 90 95
Glu Lys Leu Gly Ala Tyr Glu Leu Gln Ser Met Ala Leu Gly Glu Arg
100 105 110
Ile Gly Trp Pro Leu Leu Glu Pro Gln Ser Ser Cys Gln Thr Ala Val
115 120 125
Leu Arg Val Pro Ala Arg Ala Ala Gly Ala Ala Arg Thr Pro Pro Pro
130 135 140
Gly Gly Ala Arg Arg Pro Arg Pro His Glu Val Pro Leu Gln Val Thr
145 150 155 160
Gly Arg Arg Leu Trp Lys Asn Val Tyr Asp Glu Leu Gly Gly Ser Pro
165 170 175
Gly Ser Thr Ser Ala Ala Thr Cys Thr Arg Arg His Tyr Glu Arg Leu
180 185 190
Val Leu Pro Tyr Val Arg His Leu Lys Gly Glu Asp Asp Lys Pro Leu
195 200 205
Pro Thr Ser Lys Pro Arg Lys Gln Tyr Lys Met Ala Lys Glu Asn Arg
210 215 220
Gly Asp Asp Gly Ala Thr Glu Arg Pro Lys Lys Ala Lys Glu Glu Arg
225 230 235 240
Arg Met Asp Gln Met Met Pro Gly Lys Thr Lys Ala Asp Ala Ala Asp
245 250 255
Pro Ala Pro Leu Pro Ser Gln Glu Pro Pro Arg Asn Ser Thr Glu Gln
260 265 270
Gln Gly Leu Ala Ser Gly Ser Ser Val Ser Phe Val Gly Ala Ser Gly
275 280 285
Cys Pro Glu Ala Tyr Lys Arg Leu Leu Ser Ser Phe Tyr Cys Lys Gly
290 295 300
Thr His Gly Ile Met Ser Pro Leu Ala Lys Lys Lys Leu Leu Ala Gln
305 310 315 320
Val Ser Lys Val Glu Ala Leu Gln Cys Gln Glu Glu Gly Cys Arg His
325 330 335
Gly Ala Glu Pro Gln Ala Ser Pro Ala Val His Leu Pro Glu Ser Pro
340 345 350
Gln Ser Pro Lys Gly Leu Thr Glu Asn Ser Arg His Arg Leu Thr Pro
355 360 365
Gln Glu Gly Leu Gln Ala Pro Gly Gly Ser Leu Arg Glu Glu Ala Gln
370 375 380
Ala Gly Pro Cys Pro Ala Ala Pro Ile Phe Lys Gly Cys Phe Tyr Thr
385 390 395 400
His Pro Thr Glu Val Leu Lys Pro Val Ser Gln His Pro Arg Asp Phe
405 410 415
Phe Ser Arg Leu Lys Asp Gly Val Leu Leu Gly Pro Pro Gly Lys Glu
420 425 430
Gly Leu Ser Val Lys Glu Pro Gln Leu Val Trp Gly Gly Asp Ala Asn
435 440 445
Arg Pro Ser Ala Phe His Lys Gly Gly Ser Arg Lys Gly Ile Leu Tyr
450 455 460
Pro Lys Pro Lys Ala Cys Trp Val Ser Pro Met Ala Lys Val Pro Ala
465 470 475 480
Glu Ser Pro Thr Leu Pro Pro Thr Phe Pro Ser Ser Pro Gly Leu Gly
485 490 495
Ser Lys Arg Ser Leu Glu Glu Glu Gly Ala Ala His Ser Gly Lys Arg
500 505 510
Leu Arg Ala Val Ser Pro Phe Leu Lys Glu Ala Asp Ala Lys Lys Cys
515 520 525
Gly Ala Lys Pro Ala Gly Ser Gly Leu Val Ser Cys Leu Leu Gly Pro
530 535 540
Ala Leu Gly Pro Val Pro Pro Glu Ala Tyr Arg Gly Thr Met Leu His
545 550 555 560
Cys Pro Leu Asn Phe Thr Gly Thr Pro Gly Pro Leu Lys Gly Gln Ala
565 570 575
Ala Leu Pro Phe Ser Pro Leu Val Ile Pro Ala Phe Pro Ala His Phe
580 585 590
Leu Ala Thr Ala Gly Pro Ser Pro Met Ala Ala Gly Leu Met His Phe
595 600 605
Pro Pro Thr Ser Phe Asp Ser Ala Leu Arg His Arg Leu Cys Pro Ala
610 615 620
Ser Ser Ala Trp His Ala Pro Pro Val Thr Thr Tyr Ala Ala Pro His
625 630 635 640
Phe Phe His Leu Asn Thr Lys Leu
645
<210> 54
<211> 590
<212> PRT
<213> 小家鼠
<400> 54
Met Ala Ala Pro Pro Ala Lys Gly Asn Thr Glu Gln Ser Glu Glu Gly
1 5 10 15
Asp Leu Pro Gln Leu Pro Val Ser Pro Lys Pro Asp Asp Glu Gln Ser
20 25 30
Arg Ser Gln Ser Pro Thr Gln Leu Gln Asp Ser Pro Glu Ala Gly Gly
35 40 45
Glu Gln Glu Glu Glu Gln Ala Phe Leu Val Ser Leu Tyr Lys Phe Met
50 55 60
Lys Glu Arg His Thr Pro Ile Glu Arg Val Pro His Leu Gly Phe Lys
65 70 75 80
Gln Ile Asn Leu Trp Lys Ile Tyr Lys Ala Val Glu Lys Leu Gly Ala
85 90 95
Tyr Glu Leu Val Thr Gly Arg Arg Leu Trp Lys Asn Val Tyr Asp Glu
100 105 110
Leu Gly Gly Ser Pro Gly Ser Thr Ser Ala Ala Thr Cys Thr Arg Arg
115 120 125
His Tyr Glu Arg Leu Val Leu Pro Tyr Val Arg His Leu Lys Gly Glu
130 135 140
Asp Asp Lys Pro Leu Pro Pro Thr Lys Pro Arg Lys Gln Tyr Lys Met
145 150 155 160
Ala Lys Glu Leu Arg Gly Asp Asp Gly Thr Thr Glu Lys Leu Lys Lys
165 170 175
Ala Lys Asp Ser Glu Glu Arg Arg Val Glu Gln Thr Thr Pro Gly Lys
180 185 190
Thr Lys Ser Asp Ala Thr Gly Gln Thr Gln Leu Pro Cys Gln Gly Ser
195 200 205
Ser Arg Asp Ser Thr Glu Gln Leu Gly Pro Val Ser Gly Pro Ser Pro
210 215 220
Pro Leu Thr Gly Ala Ser Ser Cys Pro Glu Ala Tyr Lys Arg Leu Leu
225 230 235 240
Ser Ser Phe Tyr Cys Lys Gly Ala His Gly Ile Met Ser Pro Leu Ala
245 250 255
Lys Lys Lys Leu Leu Ala Gln Val Ser Lys Ala Glu Ala Leu Gln Cys
260 265 270
Gln Glu Glu Gly Cys Arg His Gly Ala Arg Ser Pro Asn Lys Asp Ile
275 280 285
Gln Asp Ser Pro Gln Asn Leu Arg Gly Pro Ala Glu Asn Ser Glu His
290 295 300
Gln Leu Thr Pro Arg Glu Gly Leu Gln Ala Pro Gly Gly Ser Thr Arg
305 310 315 320
Met Glu Ala Gln Val Gly Pro Cys Pro Thr Ala Pro Met Phe Ser Gly
325 330 335
Cys Phe His Ala Tyr Pro Thr Glu Val Leu Lys Pro Val Ser Gln His
340 345 350
Pro Arg Asp Phe Phe Ser Gly Leu Lys Asp Arg Val Leu Leu Gly Pro
355 360 365
Pro Gly Lys Glu Glu Gly Pro Thr Thr Lys Glu Ser His Leu Val Trp
370 375 380
Gly Gly Asp Ala Asn His Pro Ser Ala Phe His Lys Gly Ser Thr Arg
385 390 395 400
Lys Arg Ser Phe Tyr Pro Lys Pro Lys Ala Cys Trp Val Ser Pro Met
405 410 415
Ala Lys Val Pro Thr Glu Arg Pro Gly Ala Pro Ser Pro His Pro Ser
420 425 430
Ser Pro Gly Leu Gly Ser Lys Arg Gly Leu Glu Glu Glu Gly Phe Ala
435 440 445
His Gly Gly Lys Lys Leu Arg Ala Val Ser Pro Phe Leu Lys Glu Val
450 455 460
Asp Ser Lys Glu Thr Gly Gly Lys Pro Ala Ala Pro Gly Leu Ala Val
465 470 475 480
Ser Cys Leu Leu Gly Pro Thr Pro Gly Pro Thr Pro Pro Glu Ala Tyr
485 490 495
Arg Gly Thr Met Leu Arg Cys Pro Leu Asn Phe Thr Gly Ser Ala Asp
500 505 510
Pro Leu Lys Gly Gln Ala Ser Leu Pro Phe Ser Pro Leu Val Ile Pro
515 520 525
Ala Phe Pro Ala His Leu Leu Ala Thr Thr Gly Ser Ser Pro Met Ala
530 535 540
Ala Ser Leu Met His Phe Pro Pro Thr Pro Tyr Asp Ala Val Leu Arg
545 550 555 560
Asn Arg Leu Gly Pro Ala Ser Ser Ala Trp His Met Pro Pro Val Thr
565 570 575
Thr Tyr Ala Ala Pro His Phe Phe His Leu Asn Thr Lys Leu
580 585 590
<210> 55
<211> 835
<212> PRT
<213> 智人
<400> 55
Met Ser Arg Arg Lys Gln Gly Lys Pro Gln His Leu Ser Lys Arg Glu
1 5 10 15
Phe Ser Pro Glu Pro Leu Glu Ala Ile Leu Thr Asp Asp Glu Pro Asp
20 25 30
His Gly Pro Leu Gly Ala Pro Glu Gly Asp His Asp Leu Leu Thr Cys
35 40 45
Gly Gln Cys Gln Met Asn Phe Pro Leu Gly Asp Ile Leu Ile Phe Ile
50 55 60
Glu His Lys Arg Lys Gln Cys Asn Gly Ser Leu Cys Leu Glu Lys Ala
65 70 75 80
Val Asp Lys Pro Pro Ser Pro Ser Pro Ile Glu Met Lys Lys Ala Ser
85 90 95
Asn Pro Val Glu Val Gly Ile Gln Val Thr Pro Glu Asp Asp Asp Cys
100 105 110
Leu Ser Thr Ser Ser Arg Gly Ile Cys Pro Lys Gln Glu His Ile Ala
115 120 125
Asp Lys Leu Leu His Trp Arg Gly Leu Ser Ser Pro Arg Ser Ala His
130 135 140
Gly Ala Leu Ile Pro Thr Pro Gly Met Ser Ala Glu Tyr Ala Pro Gln
145 150 155 160
Gly Ile Cys Lys Asp Glu Pro Ser Ser Tyr Thr Cys Thr Thr Cys Lys
165 170 175
Gln Pro Phe Thr Ser Ala Trp Phe Leu Leu Gln His Ala Gln Asn Thr
180 185 190
His Gly Leu Arg Ile Tyr Leu Glu Ser Glu His Gly Ser Pro Leu Thr
195 200 205
Pro Arg Val Gly Ile Pro Ser Gly Leu Gly Ala Glu Cys Pro Ser Gln
210 215 220
Pro Pro Leu His Gly Ile His Ile Ala Asp Asn Asn Pro Phe Asn Leu
225 230 235 240
Leu Arg Ile Pro Gly Ser Val Ser Arg Glu Ala Ser Gly Leu Ala Glu
245 250 255
Gly Arg Phe Pro Pro Thr Pro Pro Leu Phe Ser Pro Pro Pro Arg His
260 265 270
His Leu Asp Pro His Arg Ile Glu Arg Leu Gly Ala Glu Glu Met Ala
275 280 285
Leu Ala Thr His His Pro Ser Ala Phe Asp Arg Val Leu Arg Leu Asn
290 295 300
Pro Met Ala Met Glu Pro Pro Ala Met Asp Phe Ser Arg Arg Leu Arg
305 310 315 320
Glu Leu Ala Gly Asn Thr Ser Ser Pro Pro Leu Ser Pro Gly Arg Pro
325 330 335
Ser Pro Met Gln Arg Leu Leu Gln Pro Phe Gln Pro Gly Ser Lys Pro
340 345 350
Pro Phe Leu Ala Thr Pro Pro Leu Pro Pro Leu Gln Ser Ala Pro Pro
355 360 365
Pro Ser Gln Pro Pro Val Lys Ser Lys Ser Cys Glu Phe Cys Gly Lys
370 375 380
Thr Phe Lys Phe Gln Ser Asn Leu Val Val His Arg Arg Ser His Thr
385 390 395 400
Gly Glu Lys Pro Tyr Lys Cys Asn Leu Cys Asp His Ala Cys Thr Gln
405 410 415
Ala Ser Lys Leu Lys Arg His Met Lys Thr His Met His Lys Ser Ser
420 425 430
Pro Met Thr Val Lys Ser Asp Asp Gly Leu Ser Thr Ala Ser Ser Pro
435 440 445
Glu Pro Gly Thr Ser Asp Leu Val Gly Ser Ala Ser Ser Ala Leu Lys
450 455 460
Ser Val Val Ala Lys Phe Lys Ser Glu Asn Asp Pro Asn Leu Ile Pro
465 470 475 480
Glu Asn Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Glu Glu Glu Glu
485 490 495
Glu Glu Glu Glu Glu Glu Glu Glu Leu Thr Glu Ser Glu Arg Val Asp
500 505 510
Tyr Gly Phe Gly Leu Ser Leu Glu Ala Ala Arg His His Glu Asn Ser
515 520 525
Ser Arg Gly Ala Val Val Gly Val Gly Asp Glu Ser Arg Ala Leu Pro
530 535 540
Asp Val Met Gln Gly Met Val Leu Ser Ser Met Gln His Phe Ser Glu
545 550 555 560
Ala Phe His Gln Val Leu Gly Glu Lys His Lys Arg Gly His Leu Ala
565 570 575
Glu Ala Glu Gly His Arg Asp Thr Cys Asp Glu Asp Ser Val Ala Gly
580 585 590
Glu Ser Asp Arg Ile Asp Asp Gly Thr Val Asn Gly Arg Gly Cys Ser
595 600 605
Pro Gly Glu Ser Ala Ser Gly Gly Leu Ser Lys Lys Leu Leu Leu Gly
610 615 620
Ser Pro Ser Ser Leu Ser Pro Phe Ser Lys Arg Ile Lys Leu Glu Lys
625 630 635 640
Glu Phe Asp Leu Pro Pro Ala Ala Met Pro Asn Thr Glu Asn Val Tyr
645 650 655
Ser Gln Trp Leu Ala Gly Tyr Ala Ala Ser Arg Gln Leu Lys Asp Pro
660 665 670
Phe Leu Ser Phe Gly Asp Ser Arg Gln Ser Pro Phe Ala Ser Ser Ser
675 680 685
Glu His Ser Ser Glu Asn Gly Ser Leu Arg Phe Ser Thr Pro Pro Gly
690 695 700
Glu Leu Asp Gly Gly Ile Ser Gly Arg Ser Gly Thr Gly Ser Gly Gly
705 710 715 720
Ser Thr Pro His Ile Ser Gly Pro Gly Pro Gly Arg Pro Ser Ser Lys
725 730 735
Glu Gly Arg Arg Ser Asp Thr Cys Glu Tyr Cys Gly Lys Val Phe Lys
740 745 750
Asn Cys Ser Asn Leu Thr Val His Arg Arg Ser His Thr Gly Glu Arg
755 760 765
Pro Tyr Lys Cys Glu Leu Cys Asn Tyr Ala Cys Ala Gln Ser Ser Lys
770 775 780
Leu Thr Arg His Met Lys Thr His Gly Gln Val Gly Lys Asp Val Tyr
785 790 795 800
Lys Cys Glu Ile Cys Lys Met Pro Phe Ser Val Tyr Ser Thr Leu Glu
805 810 815
Lys His Met Lys Lys Trp His Ser Asp Arg Val Leu Asn Asn Asp Ile
820 825 830
Lys Thr Glu
835
<210> 56
<211> 773
<212> PRT
<213> 小家鼠
<400> 56
Met Ser Arg Arg Lys Gln Gly Lys Pro Gln His Leu Ser Lys Arg Glu
1 5 10 15
Phe Ser Pro Glu Pro Leu Glu Ala Ile Leu Thr Asp Asp Glu Pro Asp
20 25 30
His Gly Pro Leu Gly Ala Pro Glu Gly Asp His Asp Leu Leu Thr Cys
35 40 45
Gly Gln Cys Gln Met Asn Phe Pro Leu Gly Asp Ile Leu Ile Phe Ile
50 55 60
Glu His Lys Arg Lys Gln Cys Asn Gly Ser Leu Cys Leu Glu Lys Gly
65 70 75 80
Val Asp Lys Pro Pro Ser Pro Ser Pro Ile Glu Met Lys Lys Ala Ser
85 90 95
Asn Pro Val Glu Val Gly Ile Gln Val Thr Pro Glu Asp Asp Asp Cys
100 105 110
Leu Ser Thr Ser Ser Arg Gly Ile Cys Pro Lys Gln Glu His Ile Ala
115 120 125
Asp Lys Leu Leu His Trp Arg Gly Leu Ser Ser Pro Arg Ser Ala His
130 135 140
Gly Ala Leu Ile Pro Thr Pro Gly Met Ser Ala Glu Tyr Ala Pro Gln
145 150 155 160
Gly Ile Cys Lys Asp Glu Pro Ser Ser Tyr Thr Cys Thr Thr Cys Lys
165 170 175
Gln Pro Phe Thr Ser Ala Trp Phe Leu Leu Gln His Ala Gln Asn Thr
180 185 190
His Gly Leu Arg Ile Tyr Leu Glu Ser Glu His Gly Ser Pro Leu Thr
195 200 205
Pro Arg Val Gly Ile Pro Ser Gly Leu Gly Ala Glu Cys Pro Ser Gln
210 215 220
Pro Pro Leu His Gly Ile His Ile Ala Asp Asn Asn Pro Phe Asn Leu
225 230 235 240
Leu Arg Ile Pro Gly Ser Val Ser Arg Glu Ala Ser Gly Leu Ala Glu
245 250 255
Gly Arg Phe Pro Pro Thr Pro Pro Leu Phe Ser Pro Pro Pro Arg His
260 265 270
His Leu Asp Pro His Arg Ile Glu Arg Leu Gly Ala Glu Glu Met Ala
275 280 285
Leu Ala Thr His His Pro Ser Ala Phe Asp Arg Val Leu Arg Leu Asn
290 295 300
Pro Met Ala Met Glu Pro Pro Ala Met Asp Phe Ser Arg Arg Leu Arg
305 310 315 320
Glu Leu Ala Gly Asn Thr Ser Ser Pro Pro Leu Ser Pro Gly Arg Pro
325 330 335
Ser Pro Met Gln Arg Leu Leu Gln Pro Phe Gln Pro Gly Ser Lys Pro
340 345 350
Pro Phe Leu Ala Thr Pro Pro Leu Pro Pro Leu Gln Ser Ala Pro Pro
355 360 365
Pro Ser Gln Pro Pro Val Lys Ser Lys Ser Cys Glu Phe Cys Gly Lys
370 375 380
Thr Phe Lys Phe Gln Ser Asn Leu Val Val His Arg Arg Ser His Thr
385 390 395 400
Gly Glu Lys Pro Tyr Lys Cys Asn Leu Cys Asp His Ala Cys Thr Gln
405 410 415
Ala Ser Lys Leu Lys Arg His Met Lys Thr His Met His Lys Ser Ser
420 425 430
Pro Met Thr Val Lys Ser Asp Asp Gly Leu Ser Thr Ala Ser Ser Pro
435 440 445
Glu Pro Gly Thr Ser Asp Leu Val Gly Ser Ala Ser Ser Ala Leu Lys
450 455 460
Ser Val Val Ala Lys Phe Lys Ser Glu Asn Asp Pro Asn Leu Ile Pro
465 470 475 480
Glu Asn Gly Asp Glu Glu Glu Glu Glu Asp Asp Glu Glu Glu Glu Glu
485 490 495
Glu Glu Glu Glu Glu Glu Glu Glu Leu Thr Glu Ser Glu Arg Val Asp
500 505 510
Tyr Gly Phe Gly Leu Ser Leu Glu Ala Ala Arg His His Glu Asn Ser
515 520 525
Ser Arg Gly Ala Val Val Gly Val Gly Asp Glu Gly Arg Ala Leu Pro
530 535 540
Asp Val Met Gln Gly Met Val Leu Ser Ser Met Gln His Phe Ser Glu
545 550 555 560
Ala Phe His Gln Val Leu Gly Glu Lys His Lys Arg Ser His Leu Ala
565 570 575
Glu Ala Glu Gly His Arg Asp Thr Cys Asp Glu Asp Ser Val Ala Gly
580 585 590
Glu Ser Asp Arg Ile Asp Asp Gly Thr Val Asn Gly Arg Gly Cys Ser
595 600 605
Pro Gly Glu Ser Ala Ser Gly Gly Leu Ser Lys Lys Leu Leu Leu Gly
610 615 620
Ser Pro Ser Ser Leu Ser Pro Phe Ser Lys Arg Ile Lys Leu Glu Lys
625 630 635 640
Glu Phe Asp Leu Pro Pro Ala Ala Met Pro Asn Thr Glu Asn Val Tyr
645 650 655
Ser Gln Trp Leu Ala Gly Tyr Ala Ala Ser Arg Gln Leu Lys Asp Pro
660 665 670
Phe Leu Thr Phe Gly Asp Ser Arg Gln Ser Pro Phe Ala Ser Ser Ser
675 680 685
Glu His Ser Ser Glu Asn Gly Ser Leu Arg Phe Ser Thr Pro Pro Gly
690 695 700
Glu Leu Asp Gly Gly Ile Ser Gly Arg Ser Gly Thr Gly Ser Gly Gly
705 710 715 720
Ser Thr Pro His Ile Ser Gly Pro Gly Pro Gly Arg Pro Ser Ser Lys
725 730 735
Glu Gly Arg Arg Ser Asp Thr Cys Pro Ser His Thr Pro Val Arg Arg
740 745 750
Ser Thr Pro Arg Ala Gln Asp Val Trp Gln Phe Ser Asp Gly Ser Ser
755 760 765
Arg Thr Leu Lys Phe
770
<210> 57
<211> 653
<212> PRT
<213> 智人
<400> 57
Met Pro Ala Ser Arg Leu Arg Asp Arg Ala Ala Ser Ser Ala Ser Gly
1 5 10 15
Ser Thr Cys Gly Ser Met Ser Gln Thr His Pro Val Leu Glu Ser Gly
20 25 30
Leu Leu Ala Ser Ala Gly Cys Ser Ala Pro Arg Gly Pro Arg Lys Gly
35 40 45
Gly Pro Ala Pro Val Asp Arg Lys Ala Lys Ala Ser Ala Met Pro Asp
50 55 60
Ser Pro Ala Glu Val Lys Thr Gln Pro Arg Ser Thr Pro Pro Ser Met
65 70 75 80
Pro Pro Pro Pro Pro Ala Ala Ser Gln Gly Ala Thr Arg Pro Pro Ser
85 90 95
Phe Thr Pro His Thr His Arg Glu Asp Gly Pro Ala Thr Leu Pro His
100 105 110
Gly Arg Phe His Gly Cys Leu Lys Trp Ser Met Val Cys Leu Leu Met
115 120 125
Asn Gly Ser Ser His Ser Pro Thr Ala Ile Asn Gly Ala Pro Cys Thr
130 135 140
Pro Asn Gly Phe Ser Asn Gly Pro Ala Thr Ser Ser Thr Ala Ser Leu
145 150 155 160
Ser Thr Gln His Leu Pro Pro Ala Cys Gly Ala Arg Gln Leu Ser Lys
165 170 175
Leu Lys Arg Phe Leu Thr Thr Leu Gln Gln Phe Gly Ser Asp Ile Ser
180 185 190
Pro Glu Ile Gly Glu Arg Val Arg Thr Leu Val Leu Gly Leu Val Asn
195 200 205
Ser Thr Leu Thr Ile Glu Glu Phe His Ser Lys Leu Gln Glu Ala Thr
210 215 220
Asn Phe Pro Leu Arg Pro Phe Val Ile Pro Phe Leu Lys Ala Asn Leu
225 230 235 240
Pro Leu Leu Gln Arg Glu Leu Leu His Cys Ala Arg Leu Ala Lys Gln
245 250 255
Thr Pro Ala Gln Tyr Leu Ala Gln His Glu Gln Leu Leu Leu Asp Ala
260 265 270
Ser Ala Ser Ser Pro Ile Asp Ser Ser Glu Leu Leu Leu Glu Val Asn
275 280 285
Glu Asn Gly Lys Arg Arg Thr Pro Asp Arg Thr Lys Glu Asn Gly Ser
290 295 300
Asp Arg Asp Pro Leu His Pro Glu His Leu Ser Lys Arg Pro Cys Thr
305 310 315 320
Leu Asn Pro Ala Gln Arg Tyr Ser Pro Ser Asn Gly Pro Pro Gln Pro
325 330 335
Thr Pro Pro Pro His Tyr Arg Leu Glu Asp Ile Ala Met Ala His His
340 345 350
Phe Arg Asp Ala Tyr Arg His Pro Asp Pro Arg Glu Leu Arg Glu Arg
355 360 365
His Arg Pro Leu Val Val Pro Gly Ser Arg Gln Glu Glu Val Ile Asp
370 375 380
His Lys Leu Thr Glu Arg Glu Trp Ala Glu Glu Trp Lys His Leu Asn
385 390 395 400
Asn Leu Leu Asn Cys Ile Met Asp Met Val Glu Lys Thr Arg Arg Ser
405 410 415
Leu Thr Val Leu Arg Arg Cys Gln Glu Ala Asp Arg Glu Glu Leu Asn
420 425 430
His Trp Ala Arg Arg Tyr Ser Asp Ala Glu Asp Thr Lys Lys Gly Pro
435 440 445
Ala Pro Ala Ala Ala Arg Pro Arg Ser Ser Ser Ala Gly Pro Glu Gly
450 455 460
Pro Gln Leu Asp Val Pro Arg Glu Phe Leu Pro Arg Thr Leu Thr Gly
465 470 475 480
Tyr Val Pro Glu Asp Ile Trp Arg Lys Ala Glu Glu Ala Val Asn Glu
485 490 495
Val Lys Arg Gln Ala Met Ser Glu Leu Gln Lys Ala Val Ser Asp Ala
500 505 510
Glu Arg Lys Ala His Glu Leu Ile Thr Thr Glu Arg Ala Lys Met Glu
515 520 525
Arg Ala Leu Ala Glu Ala Lys Arg Gln Ala Ser Glu Asp Ala Leu Thr
530 535 540
Val Ile Asn Gln Gln Glu Asp Ser Ser Glu Ser Cys Trp Asn Cys Gly
545 550 555 560
Arg Lys Ala Ser Glu Thr Cys Ser Gly Cys Asn Ala Ala Arg Tyr Cys
565 570 575
Gly Ser Phe Cys Gln His Arg Asp Trp Glu Lys His His His Val Cys
580 585 590
Gly Gln Ser Leu Gln Gly Pro Thr Ala Val Val Ala Asp Pro Val Pro
595 600 605
Gly Pro Pro Glu Ala Ala His Ser Leu Gly Pro Ser Leu Pro Val Gly
610 615 620
Ala Ala Ser Pro Ser Glu Ala Gly Ser Ala Gly Pro Ser Arg Pro Gly
625 630 635 640
Ser Pro Ser Pro Pro Gly Pro Leu Asp Thr Val Pro Arg
645 650
<210> 58
<211> 620
<212> PRT
<213> 小家鼠
<400> 58
Met Ser Gln Ala Ser Thr Thr Thr Leu Glu Ser Gly Ala Leu Leu Ser
1 5 10 15
Gly Pro Arg Gly Leu Gln Asn Gly Ser Pro Ala His Arg Lys Glu Lys
20 25 30
Ala Ala Ala Met Pro Asp Ser Pro Ala Glu Val Lys Thr Gln Pro Arg
35 40 45
Ser Thr Pro Pro Ser Met Pro Pro Pro Pro Pro Thr Ser Ser Gln Gly
50 55 60
Ala Thr Arg Pro Pro Ser Phe Thr Pro His Thr His Gly Glu Asp Gly
65 70 75 80
Pro Ala Thr Ser Leu Pro His Gly Arg Phe His Gly Cys Leu Lys Trp
85 90 95
Ser Met Val Cys Leu Leu Met Asn Gly Ser Ser His Ser Pro Thr Ala
100 105 110
Ile His Gly Ala Pro Ser Thr Pro Asn Gly Phe Ser Asn Gly Pro Ala
115 120 125
Thr Ser Ser Thr Ala Ser Leu Ser Thr Gln His Leu Pro Pro Ala Cys
130 135 140
Gly Ala Arg Gln Leu Ser Lys Leu Lys Arg Phe Leu Thr Thr Leu Gln
145 150 155 160
Gln Phe Gly Ser Asp Ile Ser Pro Glu Ile Gly Glu Arg Val Arg Thr
165 170 175
Leu Val Leu Gly Leu Val Asn Ser Thr Leu Thr Ile Glu Glu Phe His
180 185 190
Ala Lys Leu Gln Glu Ala Thr Asn Phe Pro Leu Arg Pro Phe Val Ile
195 200 205
Pro Phe Leu Lys Ala Asn Leu Pro Leu Leu Gln Arg Glu Leu Leu His
210 215 220
Cys Ala Arg Leu Ala Lys Gln Thr Pro Ala Gln Tyr Leu Ala Gln His
225 230 235 240
Glu Gln Leu Leu Leu Asp Ala Ser Ala Thr Ser Pro Val Asp Ser Ser
245 250 255
Glu Leu Leu Leu Glu Val Asn Glu Asn Gly Lys Arg Arg Thr Pro Asp
260 265 270
Arg Thr Lys Glu Asn Gly Ser Asp Arg Asp Pro Leu His Pro Asp His
275 280 285
Leu Ser Lys Arg Ser Cys Thr Leu Ser Pro Ala Gln Arg Cys Ser Pro
290 295 300
Ser Asn Gly Leu Pro His Pro Thr Pro Pro Pro Pro Pro His Tyr Arg
305 310 315 320
Leu Glu Asp Met Ala Met Ala His His Phe Arg Asp Ser Tyr Arg His
325 330 335
Pro Asp Pro Arg Glu Leu Arg Glu Arg His Arg Pro Leu Ala Ile Pro
340 345 350
Gly Ser Arg Gln Glu Glu Val Ile Asp His Arg Leu Thr Glu Arg Glu
355 360 365
Trp Ala Glu Glu Trp Lys His Leu Asn Ser Leu Leu Asn Cys Ile Met
370 375 380
Asp Met Val Glu Lys Thr Arg Arg Ser Leu Thr Val Leu Arg Arg Cys
385 390 395 400
Gln Glu Ala Asp Arg Glu Glu Leu Asn His Trp Ile Arg Cys Tyr Ser
405 410 415
Asp Ser Glu Glu Gly Lys Lys Gly Pro Thr Pro Ile Ser Ala Arg Ser
420 425 430
Leu Asn Ser Cys Ser Gly Pro Glu Gly Ser Gln Leu Asp Val His Arg
435 440 445
Asp Phe Thr Pro Arg Thr Leu Ser Gly Tyr Met Pro Glu Glu Ile Trp
450 455 460
Arg Lys Ala Glu Glu Ala Val Asn Glu Val Lys Arg Gln Ala Met Ser
465 470 475 480
Glu Leu Gln Lys Ala Val Ser Asp Ala Glu Arg Lys Ala His Glu Leu
485 490 495
Ile Thr Thr Glu Arg Ala Lys Met Glu Arg Ala Leu Ala Glu Ala Lys
500 505 510
Arg Gln Ala Ser Glu Asp Ala Leu Thr Val Ile Asn Gln Gln Glu Asp
515 520 525
Ser Ser Glu Ser Cys Trp Asn Cys Gly Arg Lys Ala Ser Glu Thr Cys
530 535 540
Ser Gly Cys Asn Ala Ala Arg Tyr Cys Gly Ser Phe Cys Gln His Lys
545 550 555 560
Asp Trp Glu Lys His His His Val Cys Gly Gln Ser Leu Gln Gly Pro
565 570 575
Ala Ala Ala Val Ala Asp Pro Leu Pro Gly Gln Pro Asp Ala Thr Ala
580 585 590
Ser Pro Ser Glu Ala Gly Ser Ala Gly Pro Ser Arg Pro Cys Ser Pro
595 600 605
Gly Pro Pro Gly Pro Leu Asp Ala Ala Val Pro Arg
610 615 620
<210> 59
<211> 520
<212> PRT
<213> 智人
<400> 59
Met Glu Val Leu Glu Ser Gly Glu Gln Gly Val Leu Gln Trp Asp Arg
1 5 10 15
Lys Leu Ser Glu Leu Ser Glu Pro Gly Asp Gly Glu Ala Leu Met Tyr
20 25 30
His Thr His Phe Ser Glu Leu Leu Asp Glu Phe Ser Gln Asn Val Leu
35 40 45
Gly Gln Leu Leu Asn Asp Pro Phe Leu Ser Glu Lys Ser Val Ser Met
50 55 60
Glu Val Glu Pro Ser Pro Thr Ser Pro Ala Pro Leu Ile Gln Ala Glu
65 70 75 80
His Ser Tyr Ser Leu Cys Glu Glu Pro Arg Ala Gln Ser Pro Phe Thr
85 90 95
His Ile Thr Thr Ser Asp Ser Phe Asn Asp Asp Glu Val Glu Ser Glu
100 105 110
Lys Trp Tyr Leu Ser Thr Asp Phe Pro Ser Thr Ser Ile Lys Thr Glu
115 120 125
Pro Val Thr Asp Glu Pro Pro Pro Gly Leu Val Pro Ser Val Thr Leu
130 135 140
Thr Ile Thr Ala Ile Ser Thr Pro Leu Glu Lys Glu Glu Pro Pro Leu
145 150 155 160
Glu Met Asn Thr Gly Val Asp Ser Ser Cys Gln Thr Ile Ile Pro Lys
165 170 175
Ile Lys Leu Glu Pro His Glu Val Asp Gln Phe Leu Asn Phe Ser Pro
180 185 190
Lys Glu Ala Pro Val Asp His Leu His Leu Pro Pro Thr Pro Pro Ser
195 200 205
Ser His Gly Ser Asp Ser Glu Gly Ser Leu Ser Pro Asn Pro Arg Leu
210 215 220
His Pro Phe Ser Leu Pro Gln Thr His Ser Pro Ser Arg Ala Ala Pro
225 230 235 240
Arg Ala Pro Ser Ala Leu Ser Ser Ser Pro Leu Leu Thr Ala Pro His
245 250 255
Lys Leu Gln Gly Ser Gly Pro Leu Val Leu Thr Glu Glu Glu Lys Arg
260 265 270
Thr Leu Ile Ala Glu Gly Tyr Pro Ile Pro Thr Lys Leu Pro Leu Ser
275 280 285
Lys Ser Glu Glu Lys Ala Leu Lys Lys Ile Arg Arg Lys Ile Lys Asn
290 295 300
Lys Ile Ser Ala Gln Glu Ser Arg Arg Lys Lys Lys Glu Tyr Met Asp
305 310 315 320
Ser Leu Glu Lys Lys Val Glu Ser Cys Ser Thr Glu Asn Leu Glu Leu
325 330 335
Arg Lys Lys Val Glu Val Leu Glu Asn Thr Asn Arg Thr Leu Leu Gln
340 345 350
Gln Leu Gln Lys Leu Gln Thr Leu Val Met Gly Lys Val Ser Arg Thr
355 360 365
Cys Lys Leu Ala Gly Thr Gln Thr Gly Thr Cys Leu Met Val Val Val
370 375 380
Leu Cys Phe Ala Val Ala Phe Gly Ser Phe Phe Gln Gly Tyr Gly Pro
385 390 395 400
Tyr Pro Ser Ala Thr Lys Met Ala Leu Pro Ser Gln His Ser Leu Gln
405 410 415
Glu Pro Tyr Thr Ala Ser Val Val Arg Ser Arg Asn Leu Leu Ile Tyr
420 425 430
Glu Glu His Ser Pro Pro Glu Glu Ser Ser Ser Pro Gly Ser Ala Gly
435 440 445
Glu Leu Gly Gly Trp Asp Arg Gly Ser Ser Leu Leu Arg Val Ser Gly
450 455 460
Leu Glu Ser Arg Pro Asp Val Asp Leu Pro His Phe Ile Ile Ser Asn
465 470 475 480
Glu Thr Ser Leu Glu Lys Ser Val Leu Leu Glu Leu Gln Gln His Leu
485 490 495
Val Ser Ala Lys Leu Glu Gly Asn Glu Thr Leu Lys Val Val Glu Leu
500 505 510
Asp Arg Arg Val Asn Thr Thr Phe
515 520
<210> 60
<211> 521
<212> PRT
<213> 小家鼠
<400> 60
Met Glu Val Leu Glu Ser Gly Glu Gln Ser Val Leu Gln Trp Asp Arg
1 5 10 15
Lys Leu Ser Glu Leu Ser Glu Pro Gly Glu Thr Glu Ala Leu Met Tyr
20 25 30
His Thr His Phe Ser Glu Leu Leu Asp Glu Phe Ser Gln Asn Val Leu
35 40 45
Gly Gln Leu Leu Ser Asp Pro Phe Leu Ser Glu Lys Ser Glu Ser Met
50 55 60
Glu Val Glu Pro Ser Pro Thr Ser Pro Ala Pro Leu Ile Gln Ala Glu
65 70 75 80
His Ser Tyr Ser Leu Ser Glu Glu Pro Arg Thr Gln Ser Pro Phe Thr
85 90 95
His Ala Ala Thr Ser Asp Ser Phe Asn Asp Glu Glu Val Glu Ser Glu
100 105 110
Lys Trp Tyr Leu Ser Thr Glu Phe Pro Ser Ala Thr Ile Lys Thr Glu
115 120 125
Pro Ile Thr Glu Glu Gln Pro Pro Gly Leu Val Pro Ser Val Thr Leu
130 135 140
Thr Ile Thr Ala Ile Ser Thr Pro Phe Glu Lys Glu Glu Ser Pro Leu
145 150 155 160
Asp Met Asn Ala Gly Gly Asp Ser Ser Cys Gln Thr Leu Ile Pro Lys
165 170 175
Ile Lys Leu Glu Pro His Glu Val Asp Gln Phe Leu Asn Phe Ser Pro
180 185 190
Lys Glu Ala Ser Val Asp Gln Leu His Leu Pro Pro Thr Pro Pro Ser
195 200 205
Ser His Ser Ser Asp Ser Glu Gly Ser Leu Ser Pro Asn Pro Arg Leu
210 215 220
His Pro Phe Ser Leu Ser Gln Ala His Ser Pro Ala Arg Ala Met Pro
225 230 235 240
Arg Gly Pro Ser Ala Leu Ser Thr Ser Pro Leu Leu Thr Ala Pro His
245 250 255
Lys Leu Gln Gly Ser Gly Pro Leu Val Leu Thr Glu Glu Glu Lys Arg
260 265 270
Thr Leu Val Ala Glu Gly Tyr Pro Ile Pro Thr Lys Leu Pro Leu Thr
275 280 285
Lys Ser Glu Glu Lys Ala Leu Lys Lys Ile Arg Arg Lys Ile Lys Asn
290 295 300
Lys Ile Ser Ala Gln Glu Ser Arg Arg Lys Lys Lys Glu Tyr Met Asp
305 310 315 320
Ser Leu Glu Lys Lys Val Glu Ser Cys Ser Thr Glu Asn Leu Glu Leu
325 330 335
Arg Lys Lys Val Glu Val Leu Glu Asn Thr Asn Arg Thr Leu Leu Gln
340 345 350
Gln Leu Gln Lys Leu Gln Thr Leu Val Met Gly Lys Val Ser Arg Thr
355 360 365
Cys Lys Leu Ala Gly Thr Gln Thr Gly Thr Cys Leu Met Val Val Val
370 375 380
Leu Cys Phe Ala Val Ala Phe Gly Ser Phe Phe Gln Gly Tyr Gly Pro
385 390 395 400
Tyr Pro Ser Ala Thr Lys Met Ala Leu Pro Ser Gln His Pro Leu Ser
405 410 415
Glu Pro Tyr Thr Ala Ser Val Val Arg Ser Arg Asn Leu Leu Ile Tyr
420 425 430
Glu Glu His Ala Pro Leu Glu Glu Ser Ser Ser Pro Ala Ser Ala Gly
435 440 445
Glu Leu Gly Gly Trp Asp Arg Gly Ser Ser Leu Leu Arg Ala Ser Ser
450 455 460
Gly Leu Glu Ala Leu Pro Glu Val Asp Leu Pro His Phe Leu Ile Ser
465 470 475 480
Asn Glu Thr Ser Leu Glu Lys Ser Val Leu Leu Glu Leu Gln Gln His
485 490 495
Leu Val Ser Ser Lys Leu Glu Gly Asn Glu Thr Leu Lys Val Val Glu
500 505 510
Leu Glu Arg Arg Val Asn Ala Thr Phe
515 520
<210> 61
<211> 485
<212> PRT
<213> 智人
<400> 61
Met Ser Tyr Phe Val Asp Ser Ala Gly Ser Ser Pro Val Pro Tyr Ser
1 5 10 15
Ala Pro Arg Pro Ala Val Val Arg Gln Gly Pro Ser Asn Thr Tyr Glu
20 25 30
Asp Pro Arg Met Asn Cys Gly Phe Gln Ser Asn Tyr His Gln Gln Arg
35 40 45
Pro Cys Tyr Pro Phe Trp Asp Glu Met Ala Thr Gln Glu Val Pro Thr
50 55 60
Gly Leu Glu His Cys Val Ser Asp Met Glu Cys Ala Asp Val Pro Leu
65 70 75 80
Leu Thr Pro Ser Ser Lys Glu Met Met Ser Gln Ala Leu Lys Ala Thr
85 90 95
Phe Ser Gly Phe Thr Lys Glu Gln Gln Arg Leu Gly Ile Pro Lys Asp
100 105 110
Pro Arg Gln Trp Thr Glu Thr His Val Arg Asp Trp Val Met Trp Ala
115 120 125
Val Asn Glu Phe Ser Leu Lys Gly Val Asp Phe Gln Lys Phe Cys Met
130 135 140
Asn Gly Ala Ala Leu Cys Ala Leu Gly Lys Asp Cys Phe Leu Glu Leu
145 150 155 160
Ala Pro Asp Phe Val Gly Asp Ile Leu Trp Glu His Leu Glu Ile Leu
165 170 175
Gln Lys Glu Asp Val Lys Pro Tyr Gln Val Asn Gly Val Asn Pro Ala
180 185 190
Tyr Pro Glu Ser Arg Tyr Thr Ser Asp Tyr Phe Ile Ser Tyr Gly Ile
195 200 205
Glu His Ala Gln Cys Val Pro Pro Ser Glu Phe Ser Glu Pro Ser Phe
210 215 220
Ile Thr Glu Ser Tyr Gln Thr Leu His Pro Ile Ser Ser Glu Glu Leu
225 230 235 240
Leu Ser Leu Lys Tyr Glu Asn Asp Tyr Pro Ser Val Ile Leu Arg Asp
245 250 255
Pro Leu Gln Thr Asp Thr Leu Gln Asn Asp Tyr Phe Ala Ile Lys Gln
260 265 270
Glu Val Val Thr Pro Asp Asn Met Cys Met Gly Arg Thr Ser Arg Gly
275 280 285
Lys Leu Gly Gly Gln Asp Ser Phe Glu Ser Ile Glu Ser Tyr Asp Ser
290 295 300
Cys Asp Arg Leu Thr Gln Ser Trp Ser Ser Gln Ser Ser Phe Asn Ser
305 310 315 320
Leu Gln Arg Val Pro Ser Tyr Asp Ser Phe Asp Ser Glu Asp Tyr Pro
325 330 335
Ala Ala Leu Pro Asn His Lys Pro Lys Gly Thr Phe Lys Asp Tyr Val
340 345 350
Arg Asp Arg Ala Asp Leu Asn Lys Asp Lys Pro Val Ile Pro Ala Ala
355 360 365
Ala Leu Ala Gly Tyr Thr Gly Ser Gly Pro Ile Gln Leu Trp Gln Phe
370 375 380
Leu Leu Glu Leu Leu Thr Asp Lys Ser Cys Gln Ser Phe Ile Ser Trp
385 390 395 400
Thr Gly Asp Gly Trp Glu Phe Lys Leu Ser Asp Pro Asp Glu Val Ala
405 410 415
Arg Arg Trp Gly Lys Arg Lys Asn Lys Pro Lys Met Asn Tyr Glu Lys
420 425 430
Leu Ser Arg Gly Leu Arg Tyr Tyr Tyr Asp Lys Asn Ile Ile His Lys
435 440 445
Thr Ala Gly Lys Arg Tyr Val Tyr Arg Phe Val Cys Asp Leu Gln Ser
450 455 460
Leu Leu Gly Tyr Thr Pro Glu Glu Leu His Ala Met Leu Asp Val Lys
465 470 475 480
Pro Asp Ala Asp Glu
485
<210> 62
<211> 440
<212> PRT
<213> 小家鼠
<400> 62
Met Lys Ala Ala Val Asp Leu Lys Pro Thr Leu Thr Ile Ile Lys Thr
1 5 10 15
Glu Lys Val Asp Leu Glu Leu Phe Pro Ser Pro Asp Met Glu Cys Ala
20 25 30
Asp Val Pro Leu Leu Thr Pro Ser Ser Lys Glu Met Met Ser Gln Ala
35 40 45
Leu Lys Ala Thr Phe Ser Gly Phe Thr Lys Glu Gln Gln Arg Leu Gly
50 55 60
Ile Pro Lys Asp Pro Arg Gln Trp Thr Glu Thr His Val Arg Asp Trp
65 70 75 80
Val Met Trp Ala Val Asn Glu Phe Ser Leu Lys Gly Val Asp Phe Gln
85 90 95
Lys Phe Cys Met Ser Gly Ala Ala Leu Cys Ala Leu Gly Lys Glu Cys
100 105 110
Phe Leu Glu Leu Ala Pro Asp Phe Val Gly Asp Ile Leu Trp Glu His
115 120 125
Leu Glu Ile Leu Gln Lys Glu Asp Val Lys Pro Tyr Gln Val Asn Gly
130 135 140
Ala Asn Pro Thr Tyr Pro Glu Ser Cys Tyr Thr Ser Asp Tyr Phe Ile
145 150 155 160
Ser Tyr Gly Ile Glu His Ala Gln Cys Val Pro Pro Ser Glu Phe Ser
165 170 175
Glu Pro Ser Phe Ile Thr Glu Ser Tyr Gln Thr Leu His Pro Ile Ser
180 185 190
Ser Glu Glu Leu Leu Ser Leu Lys Tyr Glu Asn Asp Tyr Pro Ser Val
195 200 205
Ile Leu Gln Asp Pro Leu Gln Thr Asp Thr Leu Gln Thr Asp Tyr Phe
210 215 220
Ala Ile Lys Gln Glu Val Leu Thr Pro Asp Asn Met Cys Leu Gly Arg
225 230 235 240
Ala Ser Arg Gly Lys Leu Gly Gly Gln Asp Ser Phe Glu Ser Val Glu
245 250 255
Ser Tyr Asp Ser Cys Asp Arg Leu Thr Gln Ser Trp Ser Ser Gln Ser
260 265 270
Ser Phe Asn Ser Leu Gln Arg Val Pro Ser Tyr Asp Ser Phe Asp Tyr
275 280 285
Glu Asp Tyr Pro Ala Ala Leu Pro Asn His Lys Pro Lys Gly Thr Phe
290 295 300
Lys Asp Tyr Val Arg Asp Arg Ala Asp Leu Asn Lys Asp Lys Pro Val
305 310 315 320
Ile Pro Ala Ala Ala Leu Ala Gly Tyr Thr Gly Ser Gly Pro Ile Gln
325 330 335
Leu Trp Gln Phe Leu Leu Glu Leu Leu Thr Asp Lys Ser Cys Gln Ser
340 345 350
Phe Ile Ser Trp Thr Gly Asp Gly Trp Glu Phe Lys Leu Ser Asp Pro
355 360 365
Asp Glu Val Ala Arg Arg Trp Gly Lys Arg Lys Asn Lys Pro Lys Met
370 375 380
Asn Tyr Glu Lys Leu Ser Arg Gly Leu Arg Tyr Tyr Tyr Asp Lys Asn
385 390 395 400
Ile Ile His Lys Thr Ala Gly Lys Arg Tyr Val Tyr Arg Phe Val Cys
405 410 415
Asp Leu Gln Ser Leu Leu Gly Tyr Thr Pro Glu Glu Leu His Ala Met
420 425 430
Leu Asp Val Lys Pro Asp Ala Asp
435 440
<210> 63
<211> 1123
<212> PRT
<213> 智人
<400> 63
Met Asn Ser Pro Asn Glu Ser Ala Asp Gly Met Ser Gly Arg Glu Pro
1 5 10 15
Ser Leu Glu Ile Leu Pro Arg Thr Ser Leu His Ser Ile Pro Val Thr
20 25 30
Val Glu Val Lys Pro Val Leu Pro Arg Ala Met Pro Ser Ser Met Gly
35 40 45
Gly Gly Gly Gly Gly Ser Pro Ser Pro Val Glu Leu Arg Gly Ala Leu
50 55 60
Val Gly Ser Val Asp Pro Thr Leu Arg Glu Gln Gln Leu Gln Gln Glu
65 70 75 80
Leu Leu Ala Leu Lys Gln Gln Gln Gln Leu Gln Lys Gln Leu Leu Phe
85 90 95
Ala Glu Phe Gln Lys Gln His Asp His Leu Thr Arg Gln His Glu Val
100 105 110
Gln Leu Gln Lys His Leu Lys Gln Gln Gln Glu Met Leu Ala Ala Lys
115 120 125
Gln Gln Gln Glu Met Leu Ala Ala Lys Arg Gln Gln Glu Leu Glu Gln
130 135 140
Gln Arg Gln Arg Glu Gln Gln Arg Gln Glu Glu Leu Glu Lys Gln Arg
145 150 155 160
Leu Glu Gln Gln Leu Leu Ile Leu Arg Asn Lys Glu Lys Ser Lys Glu
165 170 175
Ser Ala Ile Ala Ser Thr Glu Val Lys Leu Arg Leu Gln Glu Phe Leu
180 185 190
Leu Ser Lys Ser Lys Glu Pro Thr Pro Gly Gly Leu Asn His Ser Leu
195 200 205
Pro Gln His Pro Lys Cys Trp Gly Ala His His Ala Ser Leu Asp Gln
210 215 220
Ser Ser Pro Pro Gln Ser Gly Pro Pro Gly Thr Pro Pro Ser Tyr Lys
225 230 235 240
Leu Pro Leu Pro Gly Pro Tyr Asp Ser Arg Asp Asp Phe Pro Leu Arg
245 250 255
Lys Thr Ala Ser Glu Pro Asn Leu Lys Val Arg Ser Arg Leu Lys Gln
260 265 270
Lys Val Ala Glu Arg Arg Ser Ser Pro Leu Leu Arg Arg Lys Asp Gly
275 280 285
Thr Val Ile Ser Thr Phe Lys Lys Arg Ala Val Glu Ile Thr Gly Ala
290 295 300
Gly Pro Gly Ala Ser Ser Val Cys Asn Ser Ala Pro Gly Ser Gly Pro
305 310 315 320
Ser Ser Pro Asn Ser Ser His Ser Thr Ile Ala Glu Asn Gly Phe Thr
325 330 335
Gly Ser Val Pro Asn Ile Pro Thr Glu Met Leu Pro Gln His Arg Ala
340 345 350
Leu Pro Leu Asp Ser Ser Pro Asn Gln Phe Ser Leu Tyr Thr Ser Pro
355 360 365
Ser Leu Pro Asn Ile Ser Leu Gly Leu Gln Ala Thr Val Thr Val Thr
370 375 380
Asn Ser His Leu Thr Ala Ser Pro Lys Leu Ser Thr Gln Gln Glu Ala
385 390 395 400
Glu Arg Gln Ala Leu Gln Ser Leu Arg Gln Gly Gly Thr Leu Thr Gly
405 410 415
Lys Phe Met Ser Thr Ser Ser Ile Pro Gly Cys Leu Leu Gly Val Ala
420 425 430
Leu Glu Gly Asp Gly Ser Pro His Gly His Ala Ser Leu Leu Gln His
435 440 445
Val Leu Leu Leu Glu Gln Ala Arg Gln Gln Ser Thr Leu Ile Ala Val
450 455 460
Pro Leu His Gly Gln Ser Pro Leu Val Thr Gly Glu Arg Val Ala Thr
465 470 475 480
Ser Met Arg Thr Val Gly Lys Leu Pro Arg His Arg Pro Leu Ser Arg
485 490 495
Thr Gln Ser Ser Pro Leu Pro Gln Ser Pro Gln Ala Leu Gln Gln Leu
500 505 510
Val Met Gln Gln Gln His Gln Gln Phe Leu Glu Lys Gln Lys Gln Gln
515 520 525
Gln Leu Gln Leu Gly Lys Ile Leu Thr Lys Thr Gly Glu Leu Pro Arg
530 535 540
Gln Pro Thr Thr His Pro Glu Glu Thr Glu Glu Glu Leu Thr Glu Gln
545 550 555 560
Gln Glu Val Leu Leu Gly Glu Gly Ala Leu Thr Met Pro Arg Glu Gly
565 570 575
Ser Thr Glu Ser Glu Ser Thr Gln Glu Asp Leu Glu Glu Glu Asp Glu
580 585 590
Glu Asp Asp Gly Glu Glu Glu Glu Asp Cys Ile Gln Val Lys Asp Glu
595 600 605
Glu Gly Glu Ser Gly Ala Glu Glu Gly Pro Asp Leu Glu Glu Pro Gly
610 615 620
Ala Gly Tyr Lys Lys Leu Phe Ser Asp Ala Gln Pro Leu Gln Pro Leu
625 630 635 640
Gln Val Tyr Gln Ala Pro Leu Ser Leu Ala Thr Val Pro His Gln Ala
645 650 655
Leu Gly Arg Thr Gln Ser Ser Pro Ala Ala Pro Gly Gly Met Lys Ser
660 665 670
Pro Pro Asp Gln Pro Val Lys His Leu Phe Thr Thr Gly Val Val Tyr
675 680 685
Asp Thr Phe Met Leu Lys His Gln Cys Met Cys Gly Asn Thr His Val
690 695 700
His Pro Glu His Ala Gly Arg Ile Gln Ser Ile Trp Ser Arg Leu Gln
705 710 715 720
Glu Thr Gly Leu Leu Ser Lys Cys Glu Arg Ile Arg Gly Arg Lys Ala
725 730 735
Thr Leu Asp Glu Ile Gln Thr Val His Ser Glu Tyr His Thr Leu Leu
740 745 750
Tyr Gly Thr Ser Pro Leu Asn Arg Gln Lys Leu Asp Ser Lys Lys Leu
755 760 765
Leu Gly Pro Ile Ser Gln Lys Met Tyr Ala Val Leu Pro Cys Gly Gly
770 775 780
Ile Gly Val Asp Ser Asp Thr Val Trp Asn Glu Met His Ser Ser Ser
785 790 795 800
Ala Val Arg Met Ala Val Gly Cys Leu Leu Glu Leu Ala Phe Lys Val
805 810 815
Ala Ala Gly Glu Leu Lys Asn Gly Phe Ala Ile Ile Arg Pro Pro Gly
820 825 830
His His Ala Glu Glu Ser Thr Ala Met Gly Phe Cys Phe Phe Asn Ser
835 840 845
Val Ala Ile Thr Ala Lys Leu Leu Gln Gln Lys Leu Asn Val Gly Lys
850 855 860
Val Leu Ile Val Asp Trp Asp Ile His His Gly Asn Gly Thr Gln Gln
865 870 875 880
Ala Phe Tyr Asn Asp Pro Ser Val Leu Tyr Ile Ser Leu His Arg Tyr
885 890 895
Asp Asn Gly Asn Phe Phe Pro Gly Ser Gly Ala Pro Glu Glu Val Gly
900 905 910
Gly Gly Pro Gly Val Gly Tyr Asn Val Asn Val Ala Trp Thr Gly Gly
915 920 925
Val Asp Pro Pro Ile Gly Asp Val Glu Tyr Leu Thr Ala Phe Arg Thr
930 935 940
Val Val Met Pro Ile Ala His Glu Phe Ser Pro Asp Val Val Leu Val
945 950 955 960
Ser Ala Gly Phe Asp Ala Val Glu Gly His Leu Ser Pro Leu Gly Gly
965 970 975
Tyr Ser Val Thr Ala Arg Cys Phe Gly His Leu Thr Arg Gln Leu Met
980 985 990
Thr Leu Ala Gly Gly Arg Val Val Leu Ala Leu Glu Gly Gly His Asp
995 1000 1005
Leu Thr Ala Ile Cys Asp Ala Ser Glu Ala Cys Val Ser Ala Leu
1010 1015 1020
Leu Ser Val Glu Leu Gln Pro Leu Asp Glu Ala Val Leu Gln Gln
1025 1030 1035
Lys Pro Asn Ile Asn Ala Val Ala Thr Leu Glu Lys Val Ile Glu
1040 1045 1050
Ile Gln Ser Lys His Trp Ser Cys Val Gln Lys Phe Ala Ala Gly
1055 1060 1065
Leu Gly Arg Ser Leu Arg Glu Ala Gln Ala Gly Glu Thr Glu Glu
1070 1075 1080
Ala Glu Thr Val Ser Ala Met Ala Leu Leu Ser Val Gly Ala Glu
1085 1090 1095
Gln Ala Gln Ala Ala Ala Ala Arg Glu His Ser Pro Arg Pro Ala
1100 1105 1110
Glu Glu Pro Met Glu Gln Glu Pro Ala Leu
1115 1120
<210> 64
<211> 1121
<212> PRT
<213> 小家鼠
<400> 64
Met Leu Leu Val Pro Lys Ala Gln Gly Leu Val Glu Met Leu Gln Thr
1 5 10 15
Ile Tyr Glu Thr Glu Ser Cys Phe Ser Ala Asp Gly Met Ser Gly Arg
20 25 30
Glu Pro Ser Leu Glu Ile Leu Pro Arg Thr Pro Leu His Ser Ile Pro
35 40 45
Val Ala Val Glu Val Lys Pro Val Leu Pro Gly Ala Met Pro Ser Ser
50 55 60
Met Gly Gly Gly Gly Gly Gly Ser Pro Ser Pro Val Glu Leu Arg Gly
65 70 75 80
Ala Leu Ala Gly Pro Met Asp Pro Ala Leu Arg Glu Gln Gln Leu Gln
85 90 95
Gln Glu Leu Leu Val Leu Lys Gln Gln Gln Gln Leu Gln Lys Gln Leu
100 105 110
Leu Phe Ala Glu Phe Gln Lys Gln His Asp His Leu Thr Arg Gln His
115 120 125
Glu Val Gln Leu Gln Lys His Leu Lys Gln Gln Gln Glu Met Leu Ala
130 135 140
Ala Lys Arg Gln Gln Glu Leu Glu Gln Gln Arg Gln Arg Glu Gln Gln
145 150 155 160
Arg Gln Glu Glu Leu Glu Lys Gln Arg Leu Glu Gln Gln Leu Leu Ile
165 170 175
Leu Arg Asn Lys Glu Lys Ser Lys Glu Ser Ala Ile Ala Ser Thr Glu
180 185 190
Val Lys Leu Arg Leu Gln Glu Phe Leu Leu Ser Lys Ser Lys Glu Pro
195 200 205
Thr Pro Gly Gly Leu Asn His Ser Leu Pro Gln His Pro Lys Cys Trp
210 215 220
Gly Ala His His Ala Ser Leu Asp Gln Ser Ser Pro Pro Gln Ser Gly
225 230 235 240
Pro Pro Gly Thr Pro Pro Ser Tyr Lys Leu Pro Leu Leu Gly Pro Tyr
245 250 255
Asp Ser Arg Asp Asp Phe Pro Leu Arg Lys Thr Ala Ser Glu Pro Asn
260 265 270
Leu Lys Val Arg Ser Arg Leu Lys Gln Lys Val Ala Glu Arg Arg Ser
275 280 285
Ser Pro Leu Leu Arg Arg Lys Asp Gly Thr Val Ile Ser Thr Phe Lys
290 295 300
Lys Arg Ala Val Glu Ile Thr Gly Thr Gly Pro Gly Val Ser Ser Val
305 310 315 320
Cys Asn Ser Ala Pro Gly Ser Gly Pro Ser Ser Pro Asn Ser Ser His
325 330 335
Ser Thr Ile Ala Glu Asn Gly Phe Thr Gly Ser Val Pro Asn Ile Pro
340 345 350
Thr Glu Met Ile Pro Gln His Arg Ala Leu Pro Leu Asp Ser Ser Pro
355 360 365
Asn Gln Phe Ser Leu Tyr Thr Ser Pro Ser Leu Pro Asn Ile Ser Leu
370 375 380
Gly Leu Gln Ala Thr Val Thr Val Thr Asn Ser His Leu Thr Ala Ser
385 390 395 400
Pro Lys Leu Ser Thr Gln Gln Glu Ala Glu Arg Gln Ala Leu Gln Ser
405 410 415
Leu Arg Gln Gly Gly Thr Leu Thr Gly Lys Phe Met Ser Thr Ser Ser
420 425 430
Ile Pro Gly Cys Leu Leu Gly Val Ala Leu Glu Gly Asp Thr Ser Pro
435 440 445
His Gly His Ala Ser Leu Leu Gln His Val Leu Leu Leu Glu Gln Ala
450 455 460
Arg Gln Gln Ser Thr Leu Ile Ala Val Pro Leu His Gly Gln Ser Pro
465 470 475 480
Leu Val Thr Gly Glu Arg Val Ala Thr Ser Met Arg Thr Val Gly Lys
485 490 495
Leu Pro Arg His Arg Pro Leu Ser Arg Thr Gln Ser Ser Pro Leu Pro
500 505 510
Gln Ser Pro Gln Ala Leu Gln Gln Leu Val Met Gln Gln Gln His Gln
515 520 525
Gln Phe Leu Glu Lys Gln Lys Gln Gln Gln Met Gln Leu Gly Lys Ile
530 535 540
Leu Thr Lys Thr Gly Glu Leu Ser Arg Gln Pro Thr Thr His Pro Glu
545 550 555 560
Glu Thr Glu Glu Glu Leu Thr Glu Gln Gln Glu Ala Leu Leu Gly Glu
565 570 575
Gly Ala Leu Thr Ile Pro Arg Glu Gly Ser Thr Glu Ser Glu Ser Thr
580 585 590
Gln Glu Asp Leu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu
595 600 605
Asp Cys Ile Gln Val Lys Asp Glu Asp Gly Glu Ser Gly Pro Asp Glu
610 615 620
Gly Pro Asp Leu Glu Glu Ser Ser Ala Gly Tyr Lys Lys Leu Phe Ala
625 630 635 640
Asp Ala Gln Gln Leu Gln Pro Leu Gln Val Tyr Gln Ala Pro Leu Ser
645 650 655
Leu Ala Thr Val Pro His Gln Ala Leu Gly Arg Thr Gln Ser Ser Pro
660 665 670
Ala Ala Pro Gly Ser Met Lys Ser Pro Thr Asp Gln Pro Thr Val Val
675 680 685
Lys His Leu Phe Thr Thr Gly Val Val Tyr Asp Thr Phe Met Leu Lys
690 695 700
His Gln Cys Met Cys Gly Asn Thr His Val His Pro Glu His Ala Gly
705 710 715 720
Arg Ile Gln Ser Ile Trp Ser Arg Leu Gln Glu Thr Gly Leu Leu Gly
725 730 735
Lys Cys Glu Arg Ile Arg Gly Arg Lys Ala Thr Leu Asp Glu Ile Gln
740 745 750
Thr Val His Ser Glu Tyr His Thr Leu Leu Tyr Gly Thr Ser Pro Leu
755 760 765
Asn Arg Gln Lys Leu Asp Ser Lys Lys Leu Leu Gly Pro Ile Ser Gln
770 775 780
Lys Met Tyr Ala Met Leu Pro Cys Gly Gly Ile Gly Val Asp Ser Asp
785 790 795 800
Thr Val Trp Asn Glu Met His Ser Ser Ser Ala Val Arg Met Ala Val
805 810 815
Gly Cys Leu Val Glu Leu Ala Phe Lys Val Ala Ala Gly Glu Leu Lys
820 825 830
Asn Gly Phe Ala Ile Ile Arg Pro Pro Gly His His Ala Glu Glu Ser
835 840 845
Thr Ala Met Gly Phe Cys Phe Phe Asn Ser Val Ala Ile Thr Ala Lys
850 855 860
Leu Leu Gln Gln Lys Leu Ser Val Gly Lys Val Leu Ile Val Asp Trp
865 870 875 880
Asp Ile His His Gly Asn Gly Thr Gln Gln Ala Phe Tyr Asn Asp Pro
885 890 895
Ser Val Leu Tyr Ile Ser Leu His Arg Tyr Asp Asn Gly Asn Phe Phe
900 905 910
Pro Gly Ser Gly Ala Pro Glu Glu Val Gly Gly Gly Pro Gly Val Gly
915 920 925
Tyr Asn Val Asn Val Ala Trp Thr Gly Gly Val Asp Pro Pro Ile Gly
930 935 940
Asp Val Glu Tyr Leu Thr Ala Phe Arg Thr Val Val Met Pro Ile Ala
945 950 955 960
Gln Glu Phe Ser Pro Asp Val Val Leu Val Ser Ala Gly Phe Asp Ala
965 970 975
Val Glu Gly His Leu Ser Pro Leu Gly Gly Tyr Ser Val Thr Ala Arg
980 985 990
Cys Phe Gly His Leu Thr Arg Gln Leu Met Thr Leu Ala Gly Gly Arg
995 1000 1005
Val Val Leu Ala Leu Glu Gly Gly His Asp Leu Thr Ala Ile Cys
1010 1015 1020
Asp Ala Ser Glu Ala Cys Val Ser Ala Leu Leu Ser Val Glu Leu
1025 1030 1035
Gln Pro Leu Asp Glu Ala Val Leu Gln Gln Lys Pro Ser Val Asn
1040 1045 1050
Ala Val Ala Thr Leu Glu Lys Val Ile Glu Ile Gln Ser Lys His
1055 1060 1065
Trp Ser Cys Val Gln Arg Phe Ala Ala Gly Leu Gly Cys Ser Leu
1070 1075 1080
Arg Glu Ala Gln Thr Gly Glu Lys Glu Glu Ala Glu Thr Val Ser
1085 1090 1095
Ala Met Ala Leu Leu Ser Val Gly Ala Glu Gln Ala Gln Ala Val
1100 1105 1110
Ala Thr Gln Glu His Ser Pro Arg
1115 1120
<210> 65
<211> 270
<212> PRT
<213> 智人
<400> 65
Met Gln Tyr Pro His Pro Gly Pro Ala Ala Gly Ala Val Gly Val Pro
1 5 10 15
Leu Tyr Ala Pro Thr Pro Leu Leu Gln Pro Ala His Pro Thr Pro Phe
20 25 30
Tyr Ile Glu Asp Ile Leu Gly Arg Gly Pro Ala Ala Pro Thr Pro Ala
35 40 45
Pro Thr Leu Pro Ser Pro Asn Ser Ser Phe Thr Ser Leu Val Ser Pro
50 55 60
Tyr Arg Thr Pro Val Tyr Glu Pro Thr Pro Ile His Pro Ala Phe Ser
65 70 75 80
His His Ser Ala Ala Ala Leu Ala Ala Ala Tyr Gly Pro Gly Gly Phe
85 90 95
Gly Gly Pro Leu Tyr Pro Phe Pro Arg Thr Val Asn Asp Tyr Thr His
100 105 110
Ala Leu Leu Arg His Asp Pro Leu Gly Lys Pro Leu Leu Trp Ser Pro
115 120 125
Phe Leu Gln Arg Pro Leu His Lys Arg Lys Gly Gly Gln Val Arg Phe
130 135 140
Ser Asn Asp Gln Thr Ile Glu Leu Glu Lys Lys Phe Glu Thr Gln Lys
145 150 155 160
Tyr Leu Ser Pro Pro Glu Arg Lys Arg Leu Ala Lys Met Leu Gln Leu
165 170 175
Ser Glu Arg Gln Val Lys Thr Trp Phe Gln Asn Arg Arg Ala Lys Trp
180 185 190
Arg Arg Leu Lys Gln Glu Asn Pro Gln Ser Asn Lys Lys Glu Glu Leu
195 200 205
Glu Ser Leu Asp Ser Ser Cys Asp Gln Arg Gln Asp Leu Pro Ser Glu
210 215 220
Gln Asn Lys Gly Ala Ser Leu Asp Ser Ser Gln Cys Ser Pro Ser Pro
225 230 235 240
Ala Ser Gln Glu Asp Leu Glu Ser Glu Ile Ser Glu Asp Ser Asp Gln
245 250 255
Glu Val Asp Ile Glu Gly Asp Lys Ser Tyr Phe Asn Ala Gly
260 265 270
<210> 66
<211> 271
<212> PRT
<213> 小家鼠
<400> 66
Met Gln Phe Pro His Pro Gly Pro Ala Ala Ala Pro Ala Val Gly Val
1 5 10 15
Pro Leu Tyr Ala Pro Thr Pro Leu Leu Gln Pro Ala His Pro Thr Pro
20 25 30
Phe Tyr Ile Asp Asp Ile Leu Gly Arg Gly Pro Ala Ala Pro Thr Pro
35 40 45
Thr Pro Thr Leu Pro Ser Pro Asn Ser Ser Phe Thr Ser Leu Val Ser
50 55 60
Ser Tyr Arg Thr Pro Val Tyr Glu Pro Thr Pro Val His Pro Ala Phe
65 70 75 80
Ser His His Pro Ala Ala Ala Leu Ala Ala Ala Tyr Gly Pro Ser Gly
85 90 95
Phe Gly Gly Pro Leu Tyr Pro Phe Pro Arg Thr Val Asn Asp Tyr Thr
100 105 110
His Ala Leu Leu Arg His Asp Pro Leu Gly Lys Pro Leu Leu Trp Ser
115 120 125
Pro Phe Leu Gln Arg Pro Leu His Lys Arg Lys Gly Gly Gln Val Arg
130 135 140
Phe Ser Asn Asp Gln Thr Val Glu Leu Glu Lys Lys Phe Glu Thr Gln
145 150 155 160
Lys Tyr Leu Ser Pro Pro Glu Arg Lys Arg Leu Ala Lys Met Leu Gln
165 170 175
Leu Ser Glu Arg Gln Val Lys Thr Trp Phe Gln Asn Arg Arg Ala Lys
180 185 190
Trp Arg Arg Leu Lys Gln Glu Asn Pro Gln Ser Asn Lys Lys Asp Ala
195 200 205
Leu Asp Ser Leu Asp Thr Ser Cys Glu Gln Gly Gln Asp Leu Pro Ser
210 215 220
Glu Gln Asn Lys Gly Ala Ser Leu Asp Arg Ser Gln Cys Ser Pro Ser
225 230 235 240
Pro Ala Ser Gln Glu Asp Pro Asp Ser Glu Ile Ser Glu Asp Ser Asp
245 250 255
Gln Glu Val Asp Ile Glu Gly Asp Lys Gly Tyr Phe Asn Ala Gly
260 265 270
<210> 67
<211> 270
<212> PRT
<213> 智人
<400> 67
Met Ser Ser Tyr Phe Val Asn Ser Phe Cys Gly Arg Tyr Pro Asn Gly
1 5 10 15
Pro Asp Tyr Gln Leu His Asn Tyr Gly Asp His Ser Ser Val Ser Glu
20 25 30
Gln Phe Arg Asp Ser Ala Ser Met His Ser Gly Arg Tyr Gly Tyr Gly
35 40 45
Tyr Asn Gly Met Asp Leu Ser Val Gly Arg Ser Gly Ser Gly His Phe
50 55 60
Gly Ser Gly Glu Arg Ala Arg Ser Tyr Ala Ala Ser Ala Ser Ala Ala
65 70 75 80
Pro Ala Glu Pro Arg Tyr Ser Gln Pro Ala Thr Ser Thr His Ser Pro
85 90 95
Gln Pro Asp Pro Leu Pro Cys Ser Ala Val Ala Pro Ser Pro Gly Ser
100 105 110
Asp Ser His His Gly Gly Lys Asn Ser Leu Ser Asn Ser Ser Gly Ala
115 120 125
Ser Ala Asp Ala Gly Ser Thr His Ile Ser Ser Arg Glu Gly Val Gly
130 135 140
Thr Ala Ser Gly Ala Glu Glu Asp Ala Pro Ala Ser Ser Glu Gln Ala
145 150 155 160
Ser Ala Gln Ser Glu Pro Ser Pro Ala Pro Pro Ala Gln Pro Gln Ile
165 170 175
Tyr Pro Trp Met Arg Lys Leu His Ile Ser His Asp Asn Ile Gly Gly
180 185 190
Pro Glu Gly Lys Arg Ala Arg Thr Ala Tyr Thr Arg Tyr Gln Thr Leu
195 200 205
Glu Leu Glu Lys Glu Phe His Phe Asn Arg Tyr Leu Thr Arg Arg Arg
210 215 220
Arg Ile Glu Ile Ala His Ala Leu Cys Leu Ser Glu Arg Gln Ile Lys
225 230 235 240
Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys Asp Asn Lys Leu
245 250 255
Lys Ser Met Ser Met Ala Ala Ala Gly Gly Ala Phe Arg Pro
260 265 270
<210> 68
<211> 270
<212> PRT
<213> 小家鼠
<400> 68
Met Ser Ser Tyr Phe Val Asn Ser Phe Cys Gly Arg Tyr Pro Asn Gly
1 5 10 15
Pro Asp Tyr Gln Leu His Asn Tyr Gly Asp His Ser Ser Val Ser Glu
20 25 30
Gln Phe Arg Asp Ser Ala Ser Met His Ser Gly Arg Tyr Gly Tyr Gly
35 40 45
Tyr Asn Gly Met Asp Leu Ser Val Gly Arg Ser Gly Ser Gly His Phe
50 55 60
Gly Ser Gly Glu Arg Ala Arg Ser Tyr Ala Ala Gly Ala Ser Ala Ala
65 70 75 80
Pro Ala Glu Pro Arg Tyr Ser Gln Pro Ala Thr Ser Thr His Ser Pro
85 90 95
Pro Pro Asp Pro Leu Pro Cys Ser Ala Val Ala Pro Ser Pro Gly Ser
100 105 110
Asp Ser His His Gly Gly Lys Asn Ser Leu Gly Asn Ser Ser Gly Ala
115 120 125
Ser Ala Asn Ala Gly Ser Thr His Ile Ser Ser Arg Glu Gly Val Gly
130 135 140
Thr Ala Ser Ala Ala Glu Glu Asp Ala Pro Ala Ser Ser Glu Gln Ala
145 150 155 160
Gly Ala Gln Ser Glu Pro Ser Pro Ala Pro Pro Ala Gln Pro Gln Ile
165 170 175
Tyr Pro Trp Met Arg Lys Leu His Ile Ser His Asp Asn Ile Gly Gly
180 185 190
Pro Glu Gly Lys Arg Ala Arg Thr Ala Tyr Thr Arg Tyr Gln Thr Leu
195 200 205
Glu Leu Glu Lys Glu Phe His Phe Asn Arg Tyr Leu Thr Arg Arg Arg
210 215 220
Arg Ile Glu Ile Ala His Ala Leu Cys Leu Ser Glu Arg Gln Ile Lys
225 230 235 240
Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys Asp Asn Lys Leu
245 250 255
Lys Ser Met Ser Met Ala Ala Ala Gly Gly Ala Phe Arg Pro
260 265 270
<210> 69
<211> 119
<212> PRT
<213> 智人
<400> 69
Met Lys Ala Leu Ser Pro Val Arg Gly Cys Tyr Glu Ala Val Cys Cys
1 5 10 15
Leu Ser Glu Arg Ser Leu Ala Ile Ala Arg Gly Arg Gly Lys Gly Pro
20 25 30
Ala Ala Glu Glu Pro Leu Ser Leu Leu Asp Asp Met Asn His Cys Tyr
35 40 45
Ser Arg Leu Arg Glu Leu Val Pro Gly Val Pro Arg Gly Thr Gln Leu
50 55 60
Ser Gln Val Glu Ile Leu Gln Arg Val Ile Asp Tyr Ile Leu Asp Leu
65 70 75 80
Gln Val Val Leu Ala Glu Pro Ala Pro Gly Pro Pro Asp Gly Pro His
85 90 95
Leu Pro Ile Gln Thr Ala Glu Leu Thr Pro Glu Leu Val Ile Ser Asn
100 105 110
Asp Lys Arg Ser Phe Cys His
115
<210> 70
<211> 119
<212> PRT
<213> 小家鼠
<400> 70
Met Lys Ala Leu Ser Pro Val Arg Gly Cys Tyr Glu Ala Val Cys Cys
1 5 10 15
Leu Ser Glu Arg Ser Leu Ala Ile Ala Arg Gly Arg Gly Lys Ser Pro
20 25 30
Ser Thr Glu Glu Pro Leu Ser Leu Leu Asp Asp Met Asn His Cys Tyr
35 40 45
Ser Arg Leu Arg Glu Leu Val Pro Gly Val Pro Arg Gly Thr Gln Leu
50 55 60
Ser Gln Val Glu Ile Leu Gln Arg Val Ile Asp Tyr Ile Leu Asp Leu
65 70 75 80
Gln Val Val Leu Ala Glu Pro Ala Pro Gly Pro Pro Asp Gly Pro His
85 90 95
Leu Pro Ile Gln Thr Ala Glu Leu Thr Pro Glu Leu Val Ile Ser Lys
100 105 110
Asp Lys Arg Ser Phe Cys His
115
<210> 71
<211> 519
<212> PRT
<213> 智人
<400> 71
Met Asp Ala Asp Glu Gly Gln Asp Met Ser Gln Val Ser Gly Lys Glu
1 5 10 15
Ser Pro Pro Val Ser Asp Thr Pro Asp Glu Gly Asp Glu Pro Met Pro
20 25 30
Ile Pro Glu Asp Leu Ser Thr Thr Ser Gly Gly Gln Gln Ser Ser Lys
35 40 45
Ser Asp Arg Val Val Ala Ser Asn Val Lys Val Glu Thr Gln Ser Asp
50 55 60
Glu Glu Asn Gly Arg Ala Cys Glu Met Asn Gly Glu Glu Cys Ala Glu
65 70 75 80
Asp Leu Arg Met Leu Asp Ala Ser Gly Glu Lys Met Asn Gly Ser His
85 90 95
Arg Asp Gln Gly Ser Ser Ala Leu Ser Gly Val Gly Gly Ile Arg Leu
100 105 110
Pro Asn Gly Lys Leu Lys Cys Asp Ile Cys Gly Ile Ile Cys Ile Gly
115 120 125
Pro Asn Val Leu Met Val His Lys Arg Ser His Thr Gly Glu Arg Pro
130 135 140
Phe Gln Cys Asn Gln Cys Gly Ala Ser Phe Thr Gln Lys Gly Asn Leu
145 150 155 160
Leu Arg His Ile Lys Leu His Ser Gly Glu Lys Pro Phe Lys Cys His
165 170 175
Leu Cys Asn Tyr Ala Cys Arg Arg Arg Asp Ala Leu Thr Gly His Leu
180 185 190
Arg Thr His Ser Val Gly Lys Pro His Lys Cys Gly Tyr Cys Gly Arg
195 200 205
Ser Tyr Lys Gln Arg Ser Ser Leu Glu Glu His Lys Glu Arg Cys His
210 215 220
Asn Tyr Leu Glu Ser Met Gly Leu Pro Gly Thr Leu Tyr Pro Val Ile
225 230 235 240
Lys Glu Glu Thr Asn His Ser Glu Met Ala Glu Asp Leu Cys Lys Ile
245 250 255
Gly Ser Glu Arg Ser Leu Val Leu Asp Arg Leu Ala Ser Asn Val Ala
260 265 270
Lys Arg Lys Ser Ser Met Pro Gln Lys Phe Leu Gly Asp Lys Gly Leu
275 280 285
Ser Asp Thr Pro Tyr Asp Ser Ser Ala Ser Tyr Glu Lys Glu Asn Glu
290 295 300
Met Met Lys Ser His Val Met Asp Gln Ala Ile Asn Asn Ala Ile Asn
305 310 315 320
Tyr Leu Gly Ala Glu Ser Leu Arg Pro Leu Val Gln Thr Pro Pro Gly
325 330 335
Gly Ser Glu Val Val Pro Val Ile Ser Pro Met Tyr Gln Leu His Lys
340 345 350
Pro Leu Ala Glu Gly Thr Pro Arg Ser Asn His Ser Ala Gln Asp Ser
355 360 365
Ala Val Glu Asn Leu Leu Leu Leu Ser Lys Ala Lys Leu Val Pro Ser
370 375 380
Glu Arg Glu Ala Ser Pro Ser Asn Ser Cys Gln Asp Ser Thr Asp Thr
385 390 395 400
Glu Ser Asn Asn Glu Glu Gln Arg Ser Gly Leu Ile Tyr Leu Thr Asn
405 410 415
His Ile Ala Pro His Ala Arg Asn Gly Leu Ser Leu Lys Glu Glu His
420 425 430
Arg Ala Tyr Asp Leu Leu Arg Ala Ala Ser Glu Asn Ser Gln Asp Ala
435 440 445
Leu Arg Val Val Ser Thr Ser Gly Glu Gln Met Lys Val Tyr Lys Cys
450 455 460
Glu His Cys Arg Val Leu Phe Leu Asp His Val Met Tyr Thr Ile His
465 470 475 480
Met Gly Cys His Gly Phe Arg Asp Pro Phe Glu Cys Asn Met Cys Gly
485 490 495
Tyr His Ser Gln Asp Arg Tyr Glu Phe Ser Ser His Ile Thr Arg Gly
500 505 510
Glu His Arg Phe His Met Ser
515
<210> 72
<211> 515
<212> PRT
<213> 小家鼠
<400> 72
Met Asp Val Asp Glu Gly Gln Asp Met Ser Gln Val Ser Gly Lys Glu
1 5 10 15
Ser Pro Pro Val Ser Asp Thr Pro Asp Glu Gly Asp Glu Pro Met Pro
20 25 30
Val Pro Glu Asp Leu Ser Thr Thr Ser Gly Ala Gln Gln Asn Ser Lys
35 40 45
Ser Asp Arg Gly Met Ala Ser Asn Val Lys Val Glu Thr Gln Ser Asp
50 55 60
Glu Glu Asn Gly Arg Ala Cys Glu Met Asn Gly Glu Glu Cys Ala Glu
65 70 75 80
Asp Leu Arg Met Leu Asp Ala Ser Gly Glu Lys Met Asn Gly Ser His
85 90 95
Arg Asp Gln Gly Ser Ser Ala Leu Ser Gly Val Gly Gly Ile Arg Leu
100 105 110
Pro Asn Gly Lys Leu Lys Cys Asp Ile Cys Gly Ile Val Cys Ile Gly
115 120 125
Pro Asn Val Leu Met Val His Lys Arg Ser His Thr Gly Glu Arg Pro
130 135 140
Phe Gln Cys Asn Gln Cys Gly Ala Ser Phe Thr Gln Lys Gly Asn Leu
145 150 155 160
Leu Arg His Ile Lys Leu His Ser Gly Glu Lys Pro Phe Lys Cys His
165 170 175
Leu Cys Asn Tyr Ala Cys Arg Arg Arg Asp Ala Leu Thr Gly His Leu
180 185 190
Arg Thr His Ser Val Gly Lys Pro His Lys Cys Gly Tyr Cys Gly Arg
195 200 205
Ser Tyr Lys Gln Arg Ser Ser Leu Glu Glu His Lys Glu Arg Cys His
210 215 220
Asn Tyr Leu Glu Ser Met Gly Leu Pro Gly Met Tyr Pro Val Ile Lys
225 230 235 240
Glu Glu Thr Asn His Asn Glu Met Ala Glu Asp Leu Cys Lys Ile Gly
245 250 255
Ala Glu Arg Ser Leu Val Leu Asp Arg Leu Ala Ser Asn Val Ala Lys
260 265 270
Arg Lys Ser Ser Met Pro Gln Lys Phe Leu Gly Asp Lys Cys Leu Ser
275 280 285
Asp Met Pro Tyr Asp Ser Ala Asn Tyr Glu Lys Glu Asp Met Met Thr
290 295 300
Ser His Val Met Asp Gln Ala Ile Asn Asn Ala Ile Asn Tyr Leu Gly
305 310 315 320
Ala Glu Ser Leu Arg Pro Leu Val Gln Thr Pro Pro Gly Ser Ser Glu
325 330 335
Val Val Pro Val Ile Ser Ser Met Tyr Gln Leu His Lys Pro Pro Ser
340 345 350
Asp Gly Pro Pro Arg Ser Asn His Ser Ala Gln Asp Ala Val Asp Asn
355 360 365
Leu Leu Leu Leu Ser Lys Ala Lys Ser Val Ser Ser Glu Arg Glu Ala
370 375 380
Ser Pro Ser Asn Ser Cys Gln Asp Ser Thr Asp Thr Glu Ser Asn Ala
385 390 395 400
Glu Glu Gln Arg Ser Gly Leu Ile Tyr Leu Thr Asn His Ile Asn Pro
405 410 415
His Ala Arg Asn Gly Leu Ala Leu Lys Glu Glu Gln Arg Ala Tyr Glu
420 425 430
Val Leu Arg Ala Ala Ser Glu Asn Ser Gln Asp Ala Phe Arg Val Val
435 440 445
Ser Thr Ser Gly Glu Gln Leu Lys Val Tyr Lys Cys Glu His Cys Arg
450 455 460
Val Leu Phe Leu Asp His Val Met Tyr Thr Ile His Met Gly Cys His
465 470 475 480
Gly Phe Arg Asp Pro Phe Glu Cys Asn Met Cys Gly Tyr His Ser Gln
485 490 495
Asp Arg Tyr Glu Phe Ser Ser His Ile Thr Arg Gly Glu His Arg Tyr
500 505 510
His Leu Ser
515
<210> 73
<211> 526
<212> PRT
<213> 智人
<400> 73
Met Glu Thr Glu Ala Ile Asp Gly Tyr Ile Thr Cys Asp Asn Glu Leu
1 5 10 15
Ser Pro Glu Arg Glu His Ser Asn Met Ala Ile Asp Leu Thr Ser Ser
20 25 30
Thr Pro Asn Gly Gln His Ala Ser Pro Ser His Met Thr Ser Thr Asn
35 40 45
Ser Val Lys Leu Glu Met Gln Ser Asp Glu Glu Cys Asp Arg Lys Pro
50 55 60
Leu Ser Arg Glu Asp Glu Ile Arg Gly His Asp Glu Gly Ser Ser Leu
65 70 75 80
Glu Glu Pro Leu Ile Glu Ser Ser Glu Val Ala Asp Asn Arg Lys Val
85 90 95
Gln Glu Leu Gln Gly Glu Gly Gly Ile Arg Leu Pro Asn Gly Lys Leu
100 105 110
Lys Cys Asp Val Cys Gly Met Val Cys Ile Gly Pro Asn Val Leu Met
115 120 125
Val His Lys Arg Ser His Thr Gly Glu Arg Pro Phe His Cys Asn Gln
130 135 140
Cys Gly Ala Ser Phe Thr Gln Lys Gly Asn Leu Leu Arg His Ile Lys
145 150 155 160
Leu His Ser Gly Glu Lys Pro Phe Lys Cys Pro Phe Cys Ser Tyr Ala
165 170 175
Cys Arg Arg Arg Asp Ala Leu Thr Gly His Leu Arg Thr His Ser Val
180 185 190
Gly Lys Pro His Lys Cys Asn Tyr Cys Gly Arg Ser Tyr Lys Gln Arg
195 200 205
Ser Ser Leu Glu Glu His Lys Glu Arg Cys His Asn Tyr Leu Gln Asn
210 215 220
Val Ser Met Glu Ala Ala Gly Gln Val Met Ser His His Val Pro Pro
225 230 235 240
Met Glu Asp Cys Lys Glu Gln Glu Pro Ile Met Asp Asn Asn Ile Ser
245 250 255
Leu Val Pro Phe Glu Arg Pro Ala Val Ile Glu Lys Leu Thr Gly Asn
260 265 270
Met Gly Lys Arg Lys Ser Ser Thr Pro Gln Lys Phe Val Gly Glu Lys
275 280 285
Leu Met Arg Phe Ser Tyr Pro Asp Ile His Phe Asp Met Asn Leu Thr
290 295 300
Tyr Glu Lys Glu Ala Glu Leu Met Gln Ser His Met Met Asp Gln Ala
305 310 315 320
Ile Asn Asn Ala Ile Thr Tyr Leu Gly Ala Glu Ala Leu His Pro Leu
325 330 335
Met Gln His Pro Pro Ser Thr Ile Ala Glu Val Ala Pro Val Ile Ser
340 345 350
Ser Ala Tyr Ser Gln Val Tyr His Pro Asn Arg Ile Glu Arg Pro Ile
355 360 365
Ser Arg Glu Thr Ala Asp Ser His Glu Asn Asn Met Asp Gly Pro Ile
370 375 380
Ser Leu Ile Arg Pro Lys Ser Arg Pro Gln Glu Arg Glu Ala Ser Pro
385 390 395 400
Ser Asn Ser Cys Leu Asp Ser Thr Asp Ser Glu Ser Ser His Asp Asp
405 410 415
His Gln Ser Tyr Gln Gly His Pro Ala Leu Asn Pro Lys Arg Lys Gln
420 425 430
Ser Pro Ala Tyr Met Lys Glu Asp Val Lys Ala Leu Asp Thr Thr Lys
435 440 445
Ala Pro Lys Gly Ser Leu Lys Asp Ile Tyr Lys Val Phe Asn Gly Glu
450 455 460
Gly Glu Gln Ile Arg Ala Phe Lys Cys Glu His Cys Arg Val Leu Phe
465 470 475 480
Leu Asp His Val Met Tyr Thr Ile His Met Gly Cys His Gly Tyr Arg
485 490 495
Asp Pro Leu Glu Cys Asn Ile Cys Gly Tyr Arg Ser Gln Asp Arg Tyr
500 505 510
Glu Phe Ser Ser His Ile Val Arg Gly Glu His Thr Phe His
515 520 525
<210> 74
<211> 526
<212> PRT
<213> 小家鼠
<400> 74
Met Glu Thr Asp Ala Ile Asp Gly Tyr Ile Thr Cys Asp Asn Glu Leu
1 5 10 15
Ser Pro Glu Gly Glu His Ala Asn Met Ala Ile Asp Leu Thr Ser Ser
20 25 30
Thr Pro Asn Gly Gln His Ala Ser Pro Ser His Met Thr Ser Thr Asn
35 40 45
Ser Val Lys Leu Glu Met Gln Ser Asp Glu Glu Cys Asp Arg Gln Pro
50 55 60
Leu Ser Arg Glu Asp Glu Ile Arg Gly His Asp Glu Gly Ser Ser Leu
65 70 75 80
Glu Glu Pro Leu Ile Glu Ser Ser Glu Val Ala Asp Asn Arg Lys Val
85 90 95
Gln Asp Leu Gln Gly Glu Gly Gly Ile Arg Leu Pro Asn Gly Lys Leu
100 105 110
Lys Cys Asp Val Cys Gly Met Val Cys Ile Gly Pro Asn Val Leu Met
115 120 125
Val His Lys Arg Ser His Thr Gly Glu Arg Pro Phe His Cys Asn Gln
130 135 140
Cys Gly Ala Ser Phe Thr Gln Lys Gly Asn Leu Leu Arg His Ile Lys
145 150 155 160
Leu His Ser Gly Glu Lys Pro Phe Lys Cys Pro Phe Cys Ser Tyr Ala
165 170 175
Cys Arg Arg Arg Asp Ala Leu Thr Gly His Leu Arg Thr His Ser Val
180 185 190
Gly Lys Pro His Lys Cys Asn Tyr Cys Gly Arg Ser Tyr Lys Gln Arg
195 200 205
Ser Ser Leu Glu Glu His Lys Glu Arg Cys His Asn Tyr Leu Gln Asn
210 215 220
Val Ser Met Glu Ala Ala Gly Gln Val Met Ser His His Val Pro Pro
225 230 235 240
Met Glu Asp Cys Lys Glu Gln Glu Pro Ile Met Asp Asn Asn Ile Ser
245 250 255
Leu Val Pro Phe Glu Arg Pro Ala Val Ile Glu Lys Leu Thr Ala Asn
260 265 270
Met Gly Lys Arg Lys Ser Ser Thr Pro Gln Lys Phe Val Gly Glu Lys
275 280 285
Leu Met Arg Phe Ser Tyr Pro Asp Ile His Phe Asp Met Asn Leu Thr
290 295 300
Tyr Glu Lys Glu Ala Glu Leu Met Gln Ser His Met Met Asp Gln Ala
305 310 315 320
Ile Asn Asn Ala Ile Thr Tyr Leu Gly Ala Glu Ala Leu His Pro Leu
325 330 335
Met Gln His Ala Pro Ser Thr Ile Ala Glu Val Ala Pro Val Ile Ser
340 345 350
Ser Ala Tyr Ser Gln Val Tyr His Pro Asn Arg Ile Glu Arg Pro Ile
355 360 365
Ser Arg Glu Thr Ser Asp Ser His Glu Asn Asn Met Asp Gly Pro Ile
370 375 380
Ser Leu Ile Arg Pro Lys Ser Arg Pro Gln Glu Arg Glu Ala Ser Pro
385 390 395 400
Ser Asn Ser Cys Leu Asp Ser Thr Asp Ser Glu Ser Ser His Asp Asp
405 410 415
Arg Gln Ser Tyr Gln Gly Asn Pro Ala Leu Asn Pro Lys Arg Lys Gln
420 425 430
Ser Pro Ala Tyr Met Lys Glu Asp Val Lys Ala Leu Asp Ala Thr Lys
435 440 445
Ala Pro Lys Gly Ser Leu Lys Asp Ile Tyr Lys Val Phe Asn Gly Glu
450 455 460
Gly Glu Gln Ile Arg Ala Phe Lys Cys Glu His Cys Arg Val Leu Phe
465 470 475 480
Leu Asp His Val Met Tyr Thr Ile His Met Gly Cys His Gly Tyr Arg
485 490 495
Asp Pro Leu Glu Cys Asn Ile Cys Gly Tyr Arg Ser Gln Asp Arg Tyr
500 505 510
Glu Phe Ser Ser His Ile Val Arg Gly Glu His Thr Phe His
515 520 525
<210> 75
<211> 509
<212> PRT
<213> 智人
<400> 75
Met Glu Asp Ile Gln Thr Asn Ala Glu Leu Lys Ser Thr Gln Glu Gln
1 5 10 15
Ser Val Pro Ala Glu Ser Ala Ala Val Leu Asn Asp Tyr Ser Leu Thr
20 25 30
Lys Ser His Glu Met Glu Asn Val Asp Ser Gly Glu Gly Pro Ala Asn
35 40 45
Glu Asp Glu Asp Ile Gly Asp Asp Ser Met Lys Val Lys Asp Glu Tyr
50 55 60
Ser Glu Arg Asp Glu Asn Val Leu Lys Ser Glu Pro Met Gly Asn Ala
65 70 75 80
Glu Glu Pro Glu Ile Pro Tyr Ser Tyr Ser Arg Glu Tyr Asn Glu Tyr
85 90 95
Glu Asn Ile Lys Leu Glu Arg His Val Val Ser Phe Asp Ser Ser Arg
100 105 110
Pro Thr Ser Gly Lys Met Asn Cys Asp Val Cys Gly Leu Ser Cys Ile
115 120 125
Ser Phe Asn Val Leu Met Val His Lys Arg Ser His Thr Gly Glu Arg
130 135 140
Pro Phe Gln Cys Asn Gln Cys Gly Ala Ser Phe Thr Gln Lys Gly Asn
145 150 155 160
Leu Leu Arg His Ile Lys Leu His Thr Gly Glu Lys Pro Phe Lys Cys
165 170 175
His Leu Cys Asn Tyr Ala Cys Gln Arg Arg Asp Ala Leu Thr Gly His
180 185 190
Leu Arg Thr His Ser Val Glu Lys Pro Tyr Lys Cys Glu Phe Cys Gly
195 200 205
Arg Ser Tyr Lys Gln Arg Ser Ser Leu Glu Glu His Lys Glu Arg Cys
210 215 220
Arg Thr Phe Leu Gln Ser Thr Asp Pro Gly Asp Thr Ala Ser Ala Glu
225 230 235 240
Ala Arg His Ile Lys Ala Glu Met Gly Ser Glu Arg Ala Leu Val Leu
245 250 255
Asp Arg Leu Ala Ser Asn Val Ala Lys Arg Lys Ser Ser Met Pro Gln
260 265 270
Lys Phe Ile Gly Glu Lys Arg His Cys Phe Asp Val Asn Tyr Asn Ser
275 280 285
Ser Tyr Met Tyr Glu Lys Glu Ser Glu Leu Ile Gln Thr Arg Met Met
290 295 300
Asp Gln Ala Ile Asn Asn Ala Ile Ser Tyr Leu Gly Ala Glu Ala Leu
305 310 315 320
Arg Pro Leu Val Gln Thr Pro Pro Ala Pro Thr Ser Glu Met Val Pro
325 330 335
Val Ile Ser Ser Met Tyr Pro Ile Ala Leu Thr Arg Ala Glu Met Ser
340 345 350
Asn Gly Ala Pro Gln Glu Leu Glu Lys Lys Ser Ile His Leu Pro Glu
355 360 365
Lys Ser Val Pro Ser Glu Arg Gly Leu Ser Pro Asn Asn Ser Gly His
370 375 380
Asp Ser Thr Asp Thr Asp Ser Asn His Glu Glu Arg Gln Asn His Ile
385 390 395 400
Tyr Gln Gln Asn His Met Val Leu Ser Arg Ala Arg Asn Gly Met Pro
405 410 415
Leu Leu Lys Glu Val Pro Arg Ser Tyr Glu Leu Leu Lys Pro Pro Pro
420 425 430
Ile Cys Pro Arg Asp Ser Val Lys Val Ile Asn Lys Glu Gly Glu Val
435 440 445
Met Asp Val Tyr Arg Cys Asp His Cys Arg Val Leu Phe Leu Asp Tyr
450 455 460
Val Met Phe Thr Ile His Met Gly Cys His Gly Phe Arg Asp Pro Phe
465 470 475 480
Glu Cys Asn Met Cys Gly Tyr Arg Ser His Asp Arg Tyr Glu Phe Ser
485 490 495
Ser His Ile Ala Arg Gly Glu His Arg Ala Leu Leu Lys
500 505
<210> 76
<211> 507
<212> PRT
<213> 小家鼠
<400> 76
Met Glu Asp Ile Gln Pro Thr Val Glu Leu Lys Ser Thr Glu Glu Gln
1 5 10 15
Pro Leu Pro Thr Glu Ser Pro Asp Ala Leu Asn Asp Tyr Ser Leu Pro
20 25 30
Lys Pro His Glu Ile Glu Asn Val Asp Ser Arg Glu Ala Pro Ala Asn
35 40 45
Glu Asp Glu Asp Ala Gly Glu Asp Ser Met Lys Val Lys Asp Glu Tyr
50 55 60
Ser Asp Arg Asp Glu Asn Ile Met Lys Pro Glu Pro Met Gly Asp Ala
65 70 75 80
Glu Glu Ser Glu Met Pro Tyr Ser Tyr Ala Arg Glu Tyr Ser Asp Tyr
85 90 95
Glu Ser Ile Lys Leu Glu Arg His Val Pro Tyr Asp Asn Ser Arg Pro
100 105 110
Thr Gly Gly Lys Met Asn Cys Asp Val Cys Gly Leu Ser Cys Ile Ser
115 120 125
Phe Asn Val Leu Met Val His Lys Arg Ser His Thr Gly Glu Arg Pro
130 135 140
Phe Gln Cys Asn Gln Cys Gly Ala Ser Phe Thr Gln Lys Gly Asn Leu
145 150 155 160
Leu Arg His Ile Lys Leu His Thr Gly Glu Lys Pro Phe Lys Cys His
165 170 175
Leu Cys Asn Tyr Ala Cys Gln Arg Arg Asp Ala Leu Thr Gly His Leu
180 185 190
Arg Thr His Ser Val Glu Lys Pro Tyr Lys Cys Glu Phe Cys Gly Arg
195 200 205
Ser Tyr Lys Gln Arg Ser Ser Leu Glu Glu His Lys Glu Arg Cys Arg
210 215 220
Ala Phe Leu Gln Asn Pro Asp Leu Gly Asp Ala Ala Ser Val Glu Ala
225 230 235 240
Arg His Ile Lys Ala Glu Met Gly Ser Glu Arg Ala Leu Val Leu Asp
245 250 255
Arg Leu Ala Ser Asn Val Ala Lys Arg Lys Ser Ser Met Pro Gln Lys
260 265 270
Phe Ile Gly Glu Lys Arg His Cys Phe Asp Ala Asn Tyr Asn Pro Gly
275 280 285
Tyr Met Tyr Glu Lys Glu Asn Glu Met Met Gln Thr Arg Met Met Asp
290 295 300
Gln Ala Ile Asn Asn Ala Ile Ser Tyr Leu Gly Ala Glu Ala Leu Arg
305 310 315 320
Pro Leu Val Gln Thr Pro Pro Ala Pro Thr Ser Glu Met Val Pro Val
325 330 335
Ile Ser Ser Val Tyr Pro Ile Ala Leu Thr Arg Ala Asp Met Pro Asn
340 345 350
Gly Ala Pro Gln Glu Met Glu Lys Lys Arg Ile Leu Leu Pro Glu Lys
355 360 365
Ile Leu Pro Ser Glu Arg Gly Leu Ser Pro Asn Asn Ser Ala Gln Asp
370 375 380
Ser Thr Asp Thr Asp Ser Asn His Glu Asp Arg Gln His Leu Tyr Gln
385 390 395 400
Gln Ser His Val Val Leu Pro Gln Ala Arg Asn Gly Met Pro Leu Leu
405 410 415
Lys Glu Val Pro Arg Ser Phe Glu Leu Leu Lys Pro Pro Pro Ile Cys
420 425 430
Leu Arg Asp Ser Ile Lys Val Ile Asn Lys Glu Gly Glu Val Met Asp
435 440 445
Val Phe Arg Cys Asp His Cys His Val Leu Phe Leu Asp Tyr Val Met
450 455 460
Phe Thr Ile His Met Gly Cys His Gly Phe Arg Asp Pro Phe Glu Cys
465 470 475 480
Asn Met Cys Gly Tyr Arg Ser His Asp Arg Tyr Glu Phe Ser Ser His
485 490 495
Ile Ala Arg Gly Glu His Arg Ala Met Leu Lys
500 505
<210> 77
<211> 419
<212> PRT
<213> 智人
<400> 77
Met Gly Glu Lys Lys Pro Glu Pro Leu Asp Phe Val Lys Asp Phe Gln
1 5 10 15
Glu Tyr Leu Thr Gln Gln Thr His His Val Asn Met Ile Ser Gly Ser
20 25 30
Val Ser Gly Asp Lys Glu Ala Glu Ala Leu Gln Gly Ala Gly Thr Asp
35 40 45
Gly Asp Gln Asn Gly Leu Asp His Pro Ser Val Glu Val Ser Leu Asp
50 55 60
Glu Asn Ser Gly Met Leu Val Asp Gly Phe Glu Arg Thr Phe Asp Gly
65 70 75 80
Lys Leu Lys Cys Arg Tyr Cys Asn Tyr Ala Ser Lys Gly Thr Ala Arg
85 90 95
Leu Ile Glu His Ile Arg Ile His Thr Gly Glu Lys Pro His Arg Cys
100 105 110
His Leu Cys Pro Phe Ala Ser Ala Tyr Glu Arg His Leu Glu Ala His
115 120 125
Met Arg Ser His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Leu Cys Ser
130 135 140
Phe Arg Cys Ser Asp Arg Ser Asn Leu Ser His His Arg Arg Arg Lys
145 150 155 160
His Lys Met Val Pro Ile Lys Gly Thr Arg Ser Ser Leu Ser Ser Lys
165 170 175
Lys Met Trp Gly Val Leu Gln Lys Lys Thr Ser Asn Leu Gly Tyr Ser
180 185 190
Arg Arg Ala Leu Ile Asn Leu Ser Pro Pro Ser Met Val Val Gln Lys
195 200 205
Pro Asp Tyr Leu Asn Asp Phe Thr His Glu Ile Pro Asn Ile Gln Thr
210 215 220
Asp Ser Tyr Glu Ser Met Ala Lys Thr Thr Pro Thr Gly Gly Leu Pro
225 230 235 240
Arg Asp Pro Gln Glu Leu Met Val Asp Asn Pro Leu Asn Gln Leu Ser
245 250 255
Thr Leu Ala Gly Gln Leu Ser Ser Leu Pro Pro Glu Asn Gln Asn Pro
260 265 270
Ala Ser Pro Asp Val Val Pro Cys Pro Asp Glu Lys Pro Phe Met Ile
275 280 285
Gln Gln Pro Ser Thr Gln Ala Val Val Ser Ala Val Ser Ala Ser Ile
290 295 300
Pro Gln Ser Ser Ser Pro Thr Ser Pro Glu Pro Arg Pro Ser His Ser
305 310 315 320
Gln Arg Asn Tyr Ser Pro Val Ala Gly Pro Ser Ser Glu Pro Ser Ala
325 330 335
His Thr Ser Thr Pro Ser Ile Gly Asn Ser Gln Pro Ser Thr Pro Ala
340 345 350
Pro Ala Leu Pro Val Gln Asp Pro Gln Leu Leu His His Cys Gln His
355 360 365
Cys Asp Met Tyr Phe Ala Asp Asn Ile Leu Tyr Thr Ile His Met Gly
370 375 380
Cys His Gly Tyr Glu Asn Pro Phe Gln Cys Asn Ile Cys Gly Cys Lys
385 390 395 400
Cys Lys Asn Lys Tyr Asp Phe Ala Cys His Phe Ala Arg Gly Gln His
405 410 415
Asn Gln His
<210> 78
<211> 419
<212> PRT
<213> 小家鼠
<400> 78
Met Gly Glu Lys Lys Pro Glu Pro Leu Asp Phe Val Lys Asp Phe Gln
1 5 10 15
Glu Tyr Leu Thr Gln Gln Thr His His Val Asn Met Ile Ser Gly Ser
20 25 30
Val Ser Gly Asp Lys Glu Ala Glu Thr Leu Gln Gly Ala Gly Thr Asp
35 40 45
Gly Asp Gln Asn Gly Leu Asp His Pro Ser Val Glu Val Ser Leu Asp
50 55 60
Glu Asn Ser Gly Met Leu Val Asp Gly Phe Glu Arg Thr Phe Asp Gly
65 70 75 80
Lys Leu Lys Cys Arg Tyr Cys Asn Tyr Ala Ser Lys Gly Thr Ala Arg
85 90 95
Leu Ile Glu His Ile Arg Ile His Thr Gly Glu Lys Pro His Arg Cys
100 105 110
His Leu Cys Pro Phe Ala Ser Ala Tyr Glu Arg His Leu Glu Ala His
115 120 125
Met Arg Ser His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Leu Cys Ser
130 135 140
Phe Arg Cys Ser Asp Arg Ser Asn Leu Ser His His Arg Arg Arg Lys
145 150 155 160
His Lys Met Val Pro Ile Lys Gly Thr Arg Ser Ser Leu Ser Ser Lys
165 170 175
Lys Met Trp Gly Val Leu Gln Lys Lys Thr Ser Asn Leu Gly Tyr Ser
180 185 190
Arg Arg Ala Leu Ile Asn Leu Ser Pro Pro Ser Met Val Val Gln Lys
195 200 205
Pro Asp Tyr Leu Asn Asp Phe Thr His Glu Ile Pro Asn Ile Gln Thr
210 215 220
Asp Ser Tyr Glu Ala Met Ala Lys Thr Thr Pro Thr Gly Gly Leu Pro
225 230 235 240
Arg Asp Pro Gln Glu Leu Met Val Asp Asn Pro Leu Asn Gln Leu Ser
245 250 255
Thr Leu Ala Gly Gln Leu Ser Ser Leu Pro Pro Glu Asn Gln Asn Pro
260 265 270
Ala Ser Pro Asp Val Asp Ala Cys Pro Asp Glu Lys Pro Phe Met Ile
275 280 285
Gln Gln Pro Ser Ala Gln Ala Val Val Ser Ala Val Ser Ala Ser Ile
290 295 300
Pro Gln Ser Ser Ser Pro Thr Ser Pro Glu Pro Arg Pro Ser His Ser
305 310 315 320
Gln Arg Asn Tyr Ser Pro Val Ala Gly Pro Ser Ser Glu Pro Ser Ala
325 330 335
His Thr Ser Thr Pro Ser Ile Gly Asn Ser Gln Pro Ser Thr Pro Ala
340 345 350
Pro Thr Leu Pro Val Gln Asp Pro Gln Leu Leu His His Cys Gln His
355 360 365
Cys Asp Val Tyr Phe Ala Asp Asn Val Leu Tyr Thr Val His Met Gly
370 375 380
Cys His Gly Tyr Asp Ser Pro Phe Gln Cys Asn Val Cys Gly Cys Lys
385 390 395 400
Cys Lys Asp Lys Tyr Asp Phe Ala Cys His Phe Ala Arg Gly Gln His
405 410 415
Asn Gln His
<210> 79
<211> 516
<212> PRT
<213> 智人
<400> 79
Met Pro Val Pro Glu Arg Pro Ala Ala Gly Pro Asp Ser Pro Arg Pro
1 5 10 15
Gly Thr Arg Arg Ala Ala Pro Arg Val Leu Phe Gly Glu Trp Leu Leu
20 25 30
Gly Glu Ile Ser Ser Gly Cys Tyr Glu Gly Leu Gln Trp Leu Asp Glu
35 40 45
Ala Arg Thr Cys Phe Arg Val Pro Trp Lys His Phe Ala Arg Lys Asp
50 55 60
Leu Ser Glu Ala Asp Ala Arg Ile Phe Lys Ala Trp Ala Val Ala Arg
65 70 75 80
Gly Arg Trp Pro Pro Ser Ser Arg Gly Gly Gly Pro Pro Pro Glu Ala
85 90 95
Glu Thr Ala Glu Arg Ala Gly Trp Lys Thr Asn Phe Arg Cys Ala Leu
100 105 110
Arg Ser Thr Arg Arg Phe Val Met Leu Arg Asp Asn Ser Gly Asp Pro
115 120 125
Ala Asp Pro His Lys Val Tyr Ala Leu Ser Arg Glu Leu Cys Trp Arg
130 135 140
Glu Gly Pro Gly Thr Asp Gln Thr Glu Ala Glu Ala Pro Ala Ala Val
145 150 155 160
Pro Pro Pro Gln Gly Gly Pro Pro Gly Pro Phe Leu Ala His Thr His
165 170 175
Ala Gly Leu Gln Ala Pro Gly Pro Leu Pro Ala Pro Ala Gly Asp Lys
180 185 190
Gly Asp Leu Leu Leu Gln Ala Val Gln Gln Ser Cys Leu Ala Asp His
195 200 205
Leu Leu Thr Ala Ser Trp Gly Ala Asp Pro Val Pro Thr Lys Ala Pro
210 215 220
Gly Glu Gly Gln Glu Gly Leu Pro Leu Thr Gly Ala Cys Ala Gly Gly
225 230 235 240
Pro Gly Leu Pro Ala Gly Glu Leu Tyr Gly Trp Ala Val Glu Thr Thr
245 250 255
Pro Ser Pro Gly Pro Gln Pro Ala Ala Leu Thr Thr Gly Glu Ala Ala
260 265 270
Ala Pro Glu Ser Pro His Gln Ala Glu Pro Tyr Leu Ser Pro Ser Pro
275 280 285
Ser Ala Cys Thr Ala Val Gln Glu Pro Ser Pro Gly Ala Leu Asp Val
290 295 300
Thr Ile Met Tyr Lys Gly Arg Thr Val Leu Gln Lys Val Val Gly His
305 310 315 320
Pro Ser Cys Thr Phe Leu Tyr Gly Pro Pro Asp Pro Ala Val Arg Ala
325 330 335
Thr Asp Pro Gln Gln Val Ala Phe Pro Ser Pro Ala Glu Leu Pro Asp
340 345 350
Gln Lys Gln Leu Arg Tyr Thr Glu Glu Leu Leu Arg His Val Ala Pro
355 360 365
Gly Leu His Leu Glu Leu Arg Gly Pro Gln Leu Trp Ala Arg Arg Met
370 375 380
Gly Lys Cys Lys Val Tyr Trp Glu Val Gly Gly Pro Pro Gly Ser Ala
385 390 395 400
Ser Pro Ser Thr Pro Ala Cys Leu Leu Pro Arg Asn Cys Asp Thr Pro
405 410 415
Ile Phe Asp Phe Arg Val Phe Phe Gln Glu Leu Val Glu Phe Arg Ala
420 425 430
Arg Gln Arg Arg Gly Ser Pro Arg Tyr Thr Ile Tyr Leu Gly Phe Gly
435 440 445
Gln Asp Leu Ser Ala Gly Arg Pro Lys Glu Lys Ser Leu Val Leu Val
450 455 460
Lys Leu Glu Pro Trp Leu Cys Arg Val His Leu Glu Gly Thr Gln Arg
465 470 475 480
Glu Gly Val Ser Ser Leu Asp Ser Ser Ser Leu Ser Leu Cys Leu Ser
485 490 495
Ser Ala Asn Ser Leu Tyr Asp Asp Ile Glu Cys Phe Leu Met Glu Leu
500 505 510
Glu Gln Pro Ala
515
<210> 80
<211> 457
<212> PRT
<213> 小家鼠
<400> 80
Met Ala Glu Val Arg Gly Val Gln Arg Val Leu Phe Gly Asp Trp Leu
1 5 10 15
Leu Gly Glu Val Ser Ser Gly Gln Tyr Glu Gly Leu Gln Trp Leu Asn
20 25 30
Glu Ala Arg Thr Val Phe Arg Val Pro Trp Lys His Phe Gly Arg Arg
35 40 45
Asp Leu Asp Glu Glu Asp Ala Gln Ile Phe Lys Ala Trp Ala Val Ala
50 55 60
Arg Gly Arg Trp Pro Pro Ser Gly Val Asn Leu Pro Pro Pro Glu Ala
65 70 75 80
Glu Ala Ala Glu Arg Arg Glu Arg Arg Gly Trp Lys Thr Asn Phe Arg
85 90 95
Cys Ala Leu His Ser Thr Gly Arg Phe Ile Leu Arg Gln Asp Asn Ser
100 105 110
Gly Asp Pro Val Asp Pro His Lys Val Tyr Glu Leu Ser Arg Glu Leu
115 120 125
Gly Ser Thr Val Gly Pro Ala Thr Glu Asn Arg Glu Glu Val Ser Leu
130 135 140
Ser Asn Ala Leu Pro Thr Gln Gly Val Ser Pro Gly Ser Phe Leu Ala
145 150 155 160
Arg Glu Asn Ala Gly Leu Gln Thr Pro Ser Pro Leu Leu Ser Ser Asp
165 170 175
Ala Gly Asp Leu Leu Leu Gln Val Leu Gln Tyr Ser His Ile Leu Glu
180 185 190
Ser Glu Ser Gly Ala Asp Pro Val Pro Pro Gln Ala Pro Gly Gln Glu
195 200 205
Gln Asp Arg Val Tyr Glu Glu Pro Tyr Ala Ala Trp Gln Val Glu Ala
210 215 220
Val Pro Ser Pro Arg Pro Gln Gln Pro Ala Leu Thr Glu Arg Ser Leu
225 230 235 240
Gly Phe Leu Asp Val Thr Ile Met Tyr Lys Gly Arg Thr Val Leu Gln
245 250 255
Ala Val Val Gly His Pro Arg Cys Val Phe Leu Tyr Ser Pro Met Ala
260 265 270
Pro Ala Val Arg Thr Ser Glu Pro Gln Pro Val Ile Phe Pro Ser Pro
275 280 285
Ala Glu Leu Pro Asp Gln Lys Gln Leu His Tyr Thr Glu Thr Leu Leu
290 295 300
Gln His Val Ser Pro Gly Leu Gln Leu Glu Leu Arg Gly Pro Ser Leu
305 310 315 320
Trp Ala Leu Arg Met Gly Lys Cys Lys Val Tyr Trp Glu Val Gly Ser
325 330 335
Pro Met Gly Thr Thr Gly Pro Ser Thr Pro Pro Gln Leu Leu Glu Arg
340 345 350
Asn Arg His Thr Pro Ile Phe Asp Phe Ser Thr Phe Phe Arg Glu Leu
355 360 365
Glu Glu Phe Arg Ala Arg Arg Arg Gln Gly Ser Pro His Tyr Thr Ile
370 375 380
Tyr Leu Gly Phe Gly Gln Asp Leu Ser Ala Gly Arg Pro Lys Glu Lys
385 390 395 400
Thr Leu Ile Leu Val Lys Leu Glu Pro Trp Val Cys Lys Ala Tyr Leu
405 410 415
Glu Gly Val Gln Arg Glu Gly Val Ser Ser Leu Asp Ser Ser Ser Leu
420 425 430
Gly Leu Cys Leu Ser Ser Thr Asn Ser Leu Tyr Glu Asp Ile Glu His
435 440 445
Phe Leu Met Asp Leu Gly Gln Trp Pro
450 455
<210> 81
<211> 473
<212> PRT
<213> 智人
<400> 81
Met Gly Arg Lys Lys Ile Gln Ile Thr Arg Ile Met Asp Glu Arg Asn
1 5 10 15
Arg Gln Val Thr Phe Thr Lys Arg Lys Phe Gly Leu Met Lys Lys Ala
20 25 30
Tyr Glu Leu Ser Val Leu Cys Asp Cys Glu Ile Ala Leu Ile Ile Phe
35 40 45
Asn Ser Thr Asn Lys Leu Phe Gln Tyr Ala Ser Thr Asp Met Asp Lys
50 55 60
Val Leu Leu Lys Tyr Thr Glu Tyr Asn Glu Pro His Glu Ser Arg Thr
65 70 75 80
Asn Ser Asp Ile Val Glu Thr Leu Arg Lys Lys Gly Leu Asn Gly Cys
85 90 95
Asp Ser Pro Asp Pro Asp Ala Asp Asp Ser Val Gly His Ser Pro Glu
100 105 110
Ser Glu Asp Lys Tyr Arg Lys Ile Asn Glu Asp Ile Asp Leu Met Ile
115 120 125
Ser Arg Gln Arg Leu Cys Ala Val Pro Pro Pro Asn Phe Glu Met Pro
130 135 140
Val Ser Ile Pro Val Ser Ser His Asn Ser Leu Val Tyr Ser Asn Pro
145 150 155 160
Val Ser Ser Leu Gly Asn Pro Asn Leu Leu Pro Leu Ala His Pro Ser
165 170 175
Leu Gln Arg Asn Ser Met Ser Pro Gly Val Thr His Arg Pro Pro Ser
180 185 190
Ala Gly Asn Thr Gly Gly Leu Met Gly Gly Asp Leu Thr Ser Gly Ala
195 200 205
Gly Thr Ser Ala Gly Asn Gly Tyr Gly Asn Pro Arg Asn Ser Pro Gly
210 215 220
Leu Leu Val Ser Pro Gly Asn Leu Asn Lys Asn Met Gln Ala Lys Ser
225 230 235 240
Pro Pro Pro Met Asn Leu Gly Met Asn Asn Arg Lys Pro Asp Leu Arg
245 250 255
Val Leu Ile Pro Pro Gly Ser Lys Asn Thr Met Pro Ser Val Ser Glu
260 265 270
Asp Val Asp Leu Leu Leu Asn Gln Arg Ile Asn Asn Ser Gln Ser Ala
275 280 285
Gln Ser Leu Ala Thr Pro Val Val Ser Val Ala Thr Pro Thr Leu Pro
290 295 300
Gly Gln Gly Met Gly Gly Tyr Pro Ser Ala Ile Ser Thr Thr Tyr Gly
305 310 315 320
Thr Glu Tyr Ser Leu Ser Ser Ala Asp Leu Ser Ser Leu Ser Gly Phe
325 330 335
Asn Thr Ala Ser Ala Leu His Leu Gly Ser Val Thr Gly Trp Gln Gln
340 345 350
Gln His Leu His Asn Met Pro Pro Ser Ala Leu Ser Gln Leu Gly Ala
355 360 365
Cys Thr Ser Thr His Leu Ser Gln Ser Ser Asn Leu Ser Leu Pro Ser
370 375 380
Thr Gln Ser Leu Asn Ile Lys Ser Glu Pro Val Ser Pro Pro Arg Asp
385 390 395 400
Arg Thr Thr Thr Pro Ser Arg Tyr Pro Gln His Thr Arg His Glu Ala
405 410 415
Gly Arg Ser Pro Val Asp Ser Leu Ser Ser Cys Ser Ser Ser Tyr Asp
420 425 430
Gly Ser Asp Arg Glu Asp His Arg Asn Glu Phe His Ser Pro Ile Gly
435 440 445
Leu Thr Arg Pro Ser Pro Asp Glu Arg Glu Ser Pro Ser Val Lys Arg
450 455 460
Met Arg Leu Ser Glu Gly Trp Ala Thr
465 470
<210> 82
<211> 466
<212> PRT
<213> 小家鼠
<400> 82
Met Gly Arg Lys Lys Ile Gln Ile Thr Arg Ile Met Asp Glu Arg Asn
1 5 10 15
Arg Gln Val Thr Phe Thr Lys Arg Lys Phe Gly Leu Met Lys Lys Ala
20 25 30
Tyr Glu Leu Ser Val Leu Cys Asp Cys Glu Ile Ala Leu Ile Ile Phe
35 40 45
Asn Ser Thr Asn Lys Leu Phe Gln Tyr Ala Ser Thr Asp Met Asp Lys
50 55 60
Val Leu Leu Lys Tyr Thr Glu Tyr Asn Glu Pro His Glu Ser Arg Thr
65 70 75 80
Asn Ser Asp Ile Val Glu Thr Leu Arg Lys Lys Gly Leu Asn Gly Cys
85 90 95
Asp Ser Pro Asp Pro Asp Ala Asp Asp Ser Val Gly His Ser Pro Glu
100 105 110
Ser Glu Asp Lys Tyr Arg Lys Ile Asn Glu Asp Ile Asp Leu Met Ile
115 120 125
Ser Arg Gln Arg Leu Cys Ala Val Pro Pro Pro Ser Phe Glu Met Pro
130 135 140
Val Thr Ile Pro Val Ser Ser His Asn Ser Leu Val Tyr Ser Asn Pro
145 150 155 160
Val Ser Thr Leu Gly Asn Pro Asn Leu Leu Pro Leu Ala His Pro Ser
165 170 175
Leu Gln Arg Asn Ser Met Ser Pro Gly Val Thr His Arg Pro Pro Ser
180 185 190
Ala Gly Asn Thr Gly Gly Leu Met Gly Gly Asp Leu Thr Ser Gly Ala
195 200 205
Gly Thr Ser Ala Gly Asn Gly Tyr Gly Asn Pro Arg Asn Ser Pro Gly
210 215 220
Leu Leu Val Ser Pro Gly Asn Leu Asn Lys Asn Ile Gln Ala Lys Ser
225 230 235 240
Pro Pro Pro Met Asn Leu Gly Met Asn Asn Arg Lys Pro Asp Leu Arg
245 250 255
Val Leu Ile Pro Pro Gly Ser Lys Asn Thr Met Pro Ser Val Asn Gln
260 265 270
Arg Ile Asn Asn Ser Gln Ser Ala Gln Ser Leu Ala Thr Pro Val Val
275 280 285
Ser Val Ala Thr Pro Thr Leu Pro Gly Gln Gly Met Gly Gly Tyr Pro
290 295 300
Ser Ala Ile Ser Thr Thr Tyr Gly Thr Glu Tyr Ser Leu Ser Ser Ala
305 310 315 320
Asp Leu Ser Ser Leu Ser Gly Phe Asn Thr Ala Ser Ala Leu His Leu
325 330 335
Gly Ser Val Thr Gly Trp Gln Gln Gln His Leu His Asn Met Pro Pro
340 345 350
Ser Ala Leu Ser Gln Leu Gly Ala Cys Thr Ser Thr His Leu Ser Gln
355 360 365
Ser Ser Asn Leu Ser Leu Pro Ser Thr Gln Ser Leu Ser Ile Lys Ser
370 375 380
Glu Pro Val Ser Pro Pro Arg Asp Arg Thr Thr Thr Pro Ser Arg Tyr
385 390 395 400
Pro Gln His Thr Thr Arg His Glu Ala Gly Arg Ser Pro Val Asp Ser
405 410 415
Leu Ser Ser Cys Ser Ser Ser Tyr Asp Gly Ser Asp Arg Glu Asp His
420 425 430
Arg Asn Glu Phe His Ser Pro Ile Gly Leu Thr Arg Pro Ser Pro Asp
435 440 445
Glu Arg Glu Ser Pro Ser Val Lys Arg Met Arg Leu Ser Glu Gly Trp
450 455 460
Ala Thr
465
<210> 83
<211> 761
<212> PRT
<213> 智人
<400> 83
Met Ala Arg Arg Pro Arg His Ser Ile Tyr Ser Ser Asp Glu Asp Asp
1 5 10 15
Glu Asp Phe Glu Met Cys Asp His Asp Tyr Asp Gly Leu Leu Pro Lys
20 25 30
Ser Gly Lys Arg His Leu Gly Lys Thr Arg Trp Thr Arg Glu Glu Asp
35 40 45
Glu Lys Leu Lys Lys Leu Val Glu Gln Asn Gly Thr Asp Asp Trp Lys
50 55 60
Val Ile Ala Asn Tyr Leu Pro Asn Arg Thr Asp Val Gln Cys Gln His
65 70 75 80
Arg Trp Gln Lys Val Leu Asn Pro Glu Leu Ile Lys Gly Pro Trp Thr
85 90 95
Lys Glu Glu Asp Gln Arg Val Ile Glu Leu Val Gln Lys Tyr Gly Pro
100 105 110
Lys Arg Trp Ser Val Ile Ala Lys His Leu Lys Gly Arg Ile Gly Lys
115 120 125
Gln Cys Arg Glu Arg Trp His Asn His Leu Asn Pro Glu Val Lys Lys
130 135 140
Thr Ser Trp Thr Glu Glu Glu Asp Arg Ile Ile Tyr Gln Ala His Lys
145 150 155 160
Arg Leu Gly Asn Arg Trp Ala Glu Ile Ala Lys Leu Leu Pro Gly Arg
165 170 175
Thr Asp Asn Ala Ile Lys Asn His Trp Asn Ser Thr Met Arg Arg Lys
180 185 190
Val Glu Gln Glu Gly Tyr Leu Gln Glu Ser Ser Lys Ala Ser Gln Pro
195 200 205
Ala Val Ala Thr Ser Phe Gln Lys Asn Ser His Leu Met Gly Phe Ala
210 215 220
Gln Ala Pro Pro Thr Ala Gln Leu Pro Ala Thr Gly Gln Pro Thr Val
225 230 235 240
Asn Asn Asp Tyr Ser Tyr Tyr His Ile Ser Glu Ala Gln Asn Val Ser
245 250 255
Ser His Val Pro Tyr Pro Val Ala Leu His Val Asn Ile Val Asn Val
260 265 270
Pro Gln Pro Ala Ala Ala Ala Ile Gln Arg His Tyr Asn Asp Glu Asp
275 280 285
Pro Glu Lys Glu Lys Arg Ile Lys Glu Leu Glu Leu Leu Leu Met Ser
290 295 300
Thr Glu Asn Glu Leu Lys Gly Gln Gln Val Leu Pro Thr Gln Asn His
305 310 315 320
Thr Cys Ser Tyr Pro Gly Trp His Ser Thr Thr Ile Ala Asp His Thr
325 330 335
Arg Pro His Gly Asp Ser Ala Pro Val Ser Cys Leu Gly Glu His His
340 345 350
Ser Thr Pro Ser Leu Pro Ala Asp Pro Gly Ser Leu Pro Glu Glu Ser
355 360 365
Ala Ser Pro Ala Arg Cys Met Ile Val His Gln Gly Thr Ile Leu Asp
370 375 380
Asn Val Lys Asn Leu Leu Glu Phe Ala Glu Thr Leu Gln Phe Ile Asp
385 390 395 400
Ser Asp Ser Ser Ser Trp Cys Asp Leu Ser Ser Phe Glu Phe Phe Glu
405 410 415
Glu Ala Asp Phe Ser Pro Ser Gln His His Thr Gly Lys Ala Leu Gln
420 425 430
Leu Gln Gln Arg Glu Gly Asn Gly Thr Lys Pro Ala Gly Glu Pro Ser
435 440 445
Pro Arg Val Asn Lys Arg Met Leu Ser Glu Ser Ser Leu Asp Pro Pro
450 455 460
Lys Val Leu Pro Pro Ala Arg His Ser Thr Ile Pro Leu Val Ile Leu
465 470 475 480
Arg Lys Lys Arg Gly Gln Ala Ser Pro Leu Ala Thr Gly Asp Cys Ser
485 490 495
Ser Phe Ile Phe Ala Asp Val Ser Ser Ser Thr Pro Lys Arg Ser Pro
500 505 510
Val Lys Ser Leu Pro Phe Ser Pro Ser Gln Phe Leu Asn Thr Ser Ser
515 520 525
Asn His Glu Asn Ser Asp Leu Glu Met Pro Ser Leu Thr Ser Thr Pro
530 535 540
Leu Ile Gly His Lys Leu Thr Val Thr Thr Pro Phe His Arg Asp Gln
545 550 555 560
Thr Val Lys Thr Gln Lys Glu Asn Thr Val Phe Arg Thr Pro Ala Ile
565 570 575
Lys Arg Ser Ile Leu Glu Ser Ser Pro Arg Thr Pro Thr Pro Phe Lys
580 585 590
His Ala Leu Ala Ala Gln Glu Ile Lys Tyr Gly Pro Leu Lys Met Leu
595 600 605
Pro Gln Thr Pro Ser His Leu Val Glu Asp Leu Gln Asp Val Ile Lys
610 615 620
Gln Glu Ser Asp Glu Ser Gly Ile Val Ala Glu Phe Gln Glu Asn Gly
625 630 635 640
Pro Pro Leu Leu Lys Lys Ile Lys Gln Glu Val Glu Ser Pro Thr Asp
645 650 655
Lys Ser Gly Asn Phe Phe Cys Ser His His Trp Glu Gly Asp Ser Leu
660 665 670
Asn Thr Gln Leu Phe Thr Gln Thr Ser Pro Val Ala Asp Ala Pro Asn
675 680 685
Ile Leu Thr Ser Ser Val Leu Met Ala Pro Ala Ser Glu Asp Glu Asp
690 695 700
Asn Val Leu Lys Ala Phe Thr Val Pro Lys Asn Arg Ser Leu Ala Ser
705 710 715 720
Pro Leu Gln Pro Cys Ser Ser Thr Trp Glu Pro Ala Ser Cys Gly Lys
725 730 735
Met Glu Glu Gln Met Thr Ser Ser Ser Gln Ala Arg Lys Tyr Val Asn
740 745 750
Ala Phe Ser Ala Arg Thr Leu Val Met
755 760
<210> 84
<211> 755
<212> PRT
<213> 小家鼠
<400> 84
Met Ala Arg Arg Pro Arg His Ser Ile Tyr Ser Ser Asp Glu Asp Asp
1 5 10 15
Glu Asp Ile Glu Met Cys Asp His Asp Tyr Asp Gly Leu Leu Pro Lys
20 25 30
Ser Gly Lys Arg His Leu Gly Lys Thr Arg Trp Thr Arg Glu Glu Asp
35 40 45
Glu Lys Leu Lys Lys Leu Val Glu Gln Asn Gly Thr Asp Asp Trp Lys
50 55 60
Val Ile Ala Asn Tyr Leu Pro Asn Arg Thr Asp Val Gln Cys Gln His
65 70 75 80
Arg Trp Gln Lys Val Leu Asn Pro Glu Leu Ile Lys Gly Pro Trp Thr
85 90 95
Lys Glu Glu Asp Gln Arg Val Ile Glu Leu Val Gln Lys Tyr Gly Pro
100 105 110
Lys Arg Trp Ser Val Ile Ala Lys His Leu Lys Gly Arg Ile Gly Lys
115 120 125
Gln Cys Arg Glu Arg Trp His Asn His Leu Asn Pro Glu Val Lys Lys
130 135 140
Thr Ser Trp Thr Glu Glu Glu Asp Arg Ile Ile Tyr Gln Ala His Lys
145 150 155 160
Arg Leu Gly Asn Arg Trp Ala Glu Ile Ala Lys Leu Leu Pro Gly Arg
165 170 175
Thr Asp Asn Ala Ile Lys Asn His Trp Asn Ser Thr Met Arg Arg Lys
180 185 190
Val Glu Gln Glu Gly Tyr Leu Gln Glu Pro Ser Lys Ala Ser Gln Thr
195 200 205
Pro Val Ala Thr Ser Phe Gln Lys Asn Asn His Leu Met Gly Phe Gly
210 215 220
His Ala Ser Pro Pro Ser Gln Leu Ser Pro Ser Gly Gln Ser Ser Val
225 230 235 240
Asn Ser Glu Tyr Pro Tyr Tyr His Ile Ala Glu Ala Gln Asn Ile Ser
245 250 255
Ser His Val Pro Tyr Pro Val Ala Leu His Val Asn Ile Val Asn Val
260 265 270
Pro Gln Pro Ala Ala Ala Ala Ile Gln Arg His Tyr Asn Asp Glu Asp
275 280 285
Pro Glu Lys Glu Lys Arg Ile Lys Glu Leu Glu Leu Leu Leu Met Ser
290 295 300
Thr Glu Asn Glu Leu Lys Gly Gln Gln Ala Leu Pro Thr Gln Asn His
305 310 315 320
Thr Cys Ser Tyr Pro Gly Trp His Ser Thr Ser Ile Val Asp Gln Thr
325 330 335
Arg Pro His Gly Asp Ser Ala Pro Val Ser Cys Leu Gly Glu His His
340 345 350
Ala Thr Pro Ser Leu Pro Ala Asp Pro Gly Ser Leu Pro Glu Glu Ser
355 360 365
Ala Ser Pro Ala Arg Cys Met Ile Val His Gln Gly Thr Ile Leu Asp
370 375 380
Asn Val Lys Asn Leu Leu Glu Phe Ala Glu Thr Leu Gln Phe Ile Asp
385 390 395 400
Ser Asp Ser Ser Trp Cys Asp Leu Ser Ser Phe Glu Phe Ser Glu Glu
405 410 415
Ala Ala Ala Phe Ser Pro Ser Gln Gln Pro Thr Gly Lys Ala Phe Gln
420 425 430
Leu Gln Gln Arg Glu Gly His Gly Thr Arg Ser Ala Gly Glu Pro Ser
435 440 445
Leu Arg Val Thr Arg Arg Val Leu Ser Glu Ala Ser Leu Gly Pro Asp
450 455 460
Ser Pro Gln Ala Arg His Ser Lys Val Pro Leu Val Val Leu Arg Lys
465 470 475 480
Arg Arg Gly Gln Ala Ser Pro Leu Ala Ala Gly Glu Pro Ser Pro Ser
485 490 495
Leu Phe Ala Asp Val Ile Ser Ser Thr Leu Lys Arg Ser Pro Val Lys
500 505 510
Ser Leu Pro Phe Ser Pro Ser Gln Phe Leu Asn Thr Ser Ser Asn His
515 520 525
Glu Ser Ser Gly Leu Asp Ala Pro Thr Leu Pro Ser Thr Pro Leu Ile
530 535 540
Gly His Lys Leu Thr Pro Cys Arg Asp Gln Thr Val Lys Thr Gln Lys
545 550 555 560
Glu Asn Ser Ile Phe Arg Thr Pro Ala Ile Lys Arg Ser Ile Leu Glu
565 570 575
Ser Ser Pro Arg Thr Pro Thr Pro Phe Lys His Ala Leu Ala Ala Gln
580 585 590
Glu Ile Lys Tyr Gly Pro Leu Lys Met Leu Pro Gln Thr Pro Ser His
595 600 605
Ala Val Glu Asp Leu Gln Asp Val Ile Lys Gln Glu Ser Asp Glu Ser
610 615 620
Gly Ile Val Ala Glu Phe Gln Glu Ser Gly Pro Pro Leu Leu Lys Lys
625 630 635 640
Ile Lys Gln Glu Val Glu Ser Pro Thr Glu Lys Ser Gly Asn Phe Phe
645 650 655
Cys Ser Asn His Trp Ala Glu Asn Ser Leu Ser Thr Gln Leu Phe Ser
660 665 670
Gln Ala Ser Pro Val Ala Asp Ala Pro Asn Ile Leu Thr Ser Ser Val
675 680 685
Leu Met Thr Pro Val Ser Glu Asp Glu Asp Asn Val Leu Lys Ala Phe
690 695 700
Thr Val Pro Lys Asn Arg Pro Leu Val Gly Pro Leu Gln Pro Cys Ser
705 710 715 720
Gly Ala Trp Glu Pro Ala Ser Cys Gly Lys Thr Glu Asp Gln Met Thr
725 730 735
Ala Ser Gly Pro Ala Arg Lys Tyr Val Asn Ala Phe Ser Ala Arg Thr
740 745 750
Leu Val Met
755
<210> 85
<211> 521
<212> PRT
<213> 智人
<400> 85
Met Ala Ser Asn Ser Leu Phe Ser Thr Val Thr Pro Cys Gln Gln Asn
1 5 10 15
Phe Phe Trp Asp Pro Ser Thr Ser Arg Arg Phe Ser Pro Pro Ser Ser
20 25 30
Ser Leu Gln Pro Gly Lys Met Ser Asp Val Ser Pro Val Val Ala Ala
35 40 45
Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln
50 55 60
Gln Gln Gln Gln Gln Gln Gln Glu Ala Ala Ala Ala Ala Ala Ala Ala
65 70 75 80
Ala Ala Ala Ala Ala Ala Ala Ala Ala Val Pro Arg Leu Arg Pro Pro
85 90 95
His Asp Asn Arg Thr Met Val Glu Ile Ile Ala Asp His Pro Ala Glu
100 105 110
Leu Val Arg Thr Asp Ser Pro Asn Phe Leu Cys Ser Val Leu Pro Ser
115 120 125
His Trp Arg Cys Asn Lys Thr Leu Pro Val Ala Phe Lys Val Val Ala
130 135 140
Leu Gly Glu Val Pro Asp Gly Thr Val Val Thr Val Met Ala Gly Asn
145 150 155 160
Asp Glu Asn Tyr Ser Ala Glu Leu Arg Asn Ala Ser Ala Val Met Lys
165 170 175
Asn Gln Val Ala Arg Phe Asn Asp Leu Arg Phe Val Gly Arg Ser Gly
180 185 190
Arg Gly Lys Ser Phe Thr Leu Thr Ile Thr Val Phe Thr Asn Pro Pro
195 200 205
Gln Val Ala Thr Tyr His Arg Ala Ile Lys Val Thr Val Asp Gly Pro
210 215 220
Arg Glu Pro Arg Arg His Arg Gln Lys Leu Asp Asp Ser Lys Pro Ser
225 230 235 240
Leu Phe Ser Asp Arg Leu Ser Asp Leu Gly Arg Ile Pro His Pro Ser
245 250 255
Met Arg Val Gly Val Pro Pro Gln Asn Pro Arg Pro Ser Leu Asn Ser
260 265 270
Ala Pro Ser Pro Phe Asn Pro Gln Gly Gln Ser Gln Ile Thr Asp Pro
275 280 285
Arg Gln Ala Gln Ser Ser Pro Pro Trp Ser Tyr Asp Gln Ser Tyr Pro
290 295 300
Ser Tyr Leu Ser Gln Met Thr Ser Pro Ser Ile His Ser Thr Thr Pro
305 310 315 320
Leu Ser Ser Thr Arg Gly Thr Gly Leu Pro Ala Ile Thr Asp Val Pro
325 330 335
Arg Arg Ile Ser Asp Asp Asp Thr Ala Thr Ser Asp Phe Cys Leu Trp
340 345 350
Pro Ser Thr Leu Ser Lys Lys Ser Gln Ala Gly Ala Ser Glu Leu Gly
355 360 365
Pro Phe Ser Asp Pro Arg Gln Phe Pro Ser Ile Ser Ser Leu Thr Glu
370 375 380
Ser Arg Phe Ser Asn Pro Arg Met His Tyr Pro Ala Thr Phe Thr Tyr
385 390 395 400
Thr Pro Pro Val Thr Ser Gly Met Ser Leu Gly Met Ser Ala Thr Thr
405 410 415
His Tyr His Thr Tyr Leu Pro Pro Pro Tyr Pro Gly Ser Ser Gln Ser
420 425 430
Gln Ser Gly Pro Phe Gln Thr Ser Ser Thr Pro Tyr Leu Tyr Tyr Gly
435 440 445
Thr Ser Ser Gly Ser Tyr Gln Phe Pro Met Val Pro Gly Gly Asp Arg
450 455 460
Ser Pro Ser Arg Met Leu Pro Pro Cys Thr Thr Thr Ser Asn Gly Ser
465 470 475 480
Thr Leu Leu Asn Pro Asn Leu Pro Asn Gln Asn Asp Gly Val Asp Ala
485 490 495
Asp Gly Ser His Ser Ser Ser Pro Thr Val Leu Asn Ser Ser Gly Arg
500 505 510
Met Asp Glu Ser Val Trp Arg Pro Tyr
515 520
<210> 86
<211> 528
<212> PRT
<213> 小家鼠
<400> 86
Met Ala Ser Asn Ser Leu Phe Ser Ala Val Thr Pro Cys Gln Gln Ser
1 5 10 15
Phe Phe Trp Asp Pro Ser Thr Ser Arg Arg Phe Ser Pro Pro Ser Ser
20 25 30
Ser Leu Gln Pro Gly Lys Met Ser Asp Val Ser Pro Val Val Ala Ala
35 40 45
Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln
50 55 60
Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Glu Ala Ala
65 70 75 80
Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala
85 90 95
Val Pro Arg Leu Arg Pro Pro His Asp Asn Arg Thr Met Val Glu Ile
100 105 110
Ile Ala Asp His Pro Ala Glu Leu Val Arg Thr Asp Ser Pro Asn Phe
115 120 125
Leu Cys Ser Val Leu Pro Ser His Trp Arg Cys Asn Lys Thr Leu Pro
130 135 140
Val Ala Phe Lys Val Val Ala Leu Gly Glu Val Pro Asp Gly Thr Val
145 150 155 160
Val Thr Val Met Ala Gly Asn Asp Glu Asn Tyr Ser Ala Glu Leu Arg
165 170 175
Asn Ala Ser Ala Val Met Lys Asn Gln Val Ala Arg Phe Asn Asp Leu
180 185 190
Arg Phe Val Gly Arg Ser Gly Arg Gly Lys Ser Phe Thr Leu Thr Ile
195 200 205
Thr Val Phe Thr Asn Pro Pro Gln Val Ala Thr Tyr His Arg Ala Ile
210 215 220
Lys Val Thr Val Asp Gly Pro Arg Glu Pro Arg Arg His Arg Gln Lys
225 230 235 240
Leu Asp Asp Ser Lys Pro Ser Leu Phe Ser Asp Arg Leu Ser Asp Leu
245 250 255
Gly Arg Ile Pro His Pro Ser Met Arg Val Gly Val Pro Pro Gln Asn
260 265 270
Pro Arg Pro Ser Leu Asn Ser Ala Pro Ser Pro Phe Asn Pro Gln Gly
275 280 285
Gln Ser Gln Ile Thr Asp Pro Arg Gln Ala Gln Ser Ser Pro Pro Trp
290 295 300
Ser Tyr Asp Gln Ser Tyr Pro Ser Tyr Leu Ser Gln Met Thr Ser Pro
305 310 315 320
Ser Ile His Ser Thr Thr Pro Leu Ser Ser Thr Arg Gly Thr Gly Leu
325 330 335
Pro Ala Ile Thr Asp Val Pro Arg Arg Ile Ser Asp Asp Asp Thr Ala
340 345 350
Thr Ser Asp Phe Cys Leu Trp Pro Ser Ser Leu Ser Lys Lys Ser Gln
355 360 365
Ala Gly Ala Ser Glu Leu Gly Pro Phe Ser Asp Pro Arg Gln Phe Pro
370 375 380
Ser Ile Ser Ser Leu Thr Glu Ser Arg Phe Ser Asn Pro Arg Met His
385 390 395 400
Tyr Pro Ala Thr Phe Thr Tyr Thr Pro Pro Val Thr Ser Gly Met Ser
405 410 415
Leu Gly Met Ser Ala Thr Thr His Tyr His Thr Tyr Leu Pro Pro Pro
420 425 430
Tyr Pro Gly Ser Ser Gln Ser Gln Ser Gly Pro Phe Gln Thr Ser Ser
435 440 445
Thr Pro Tyr Leu Tyr Tyr Gly Thr Ser Ser Ala Ser Tyr Gln Phe Pro
450 455 460
Met Val Pro Gly Gly Asp Arg Ser Pro Ser Arg Met Val Pro Pro Cys
465 470 475 480
Thr Thr Thr Ser Asn Gly Ser Thr Leu Leu Asn Pro Asn Leu Pro Asn
485 490 495
Gln Asn Asp Gly Val Asp Ala Asp Gly Ser His Ser Ser Ser Pro Thr
500 505 510
Val Leu Asn Ser Ser Gly Arg Met Asp Glu Ser Val Trp Arg Pro Tyr
515 520 525
<210> 87
<211> 770
<212> PRT
<213> 智人
<400> 87
Met Ala Gln Trp Asn Gln Leu Gln Gln Leu Asp Thr Arg Tyr Leu Glu
1 5 10 15
Gln Leu His Gln Leu Tyr Ser Asp Ser Phe Pro Met Glu Leu Arg Gln
20 25 30
Phe Leu Ala Pro Trp Ile Glu Ser Gln Asp Trp Ala Tyr Ala Ala Ser
35 40 45
Lys Glu Ser His Ala Thr Leu Val Phe His Asn Leu Leu Gly Glu Ile
50 55 60
Asp Gln Gln Tyr Ser Arg Phe Leu Gln Glu Ser Asn Val Leu Tyr Gln
65 70 75 80
His Asn Leu Arg Arg Ile Lys Gln Phe Leu Gln Ser Arg Tyr Leu Glu
85 90 95
Lys Pro Met Glu Ile Ala Arg Ile Val Ala Arg Cys Leu Trp Glu Glu
100 105 110
Ser Arg Leu Leu Gln Thr Ala Ala Thr Ala Ala Gln Gln Gly Gly Gln
115 120 125
Ala Asn His Pro Thr Ala Ala Val Val Thr Glu Lys Gln Gln Met Leu
130 135 140
Glu Gln His Leu Gln Asp Val Arg Lys Arg Val Gln Asp Leu Glu Gln
145 150 155 160
Lys Met Lys Val Val Glu Asn Leu Gln Asp Asp Phe Asp Phe Asn Tyr
165 170 175
Lys Thr Leu Lys Ser Gln Gly Asp Met Gln Asp Leu Asn Gly Asn Asn
180 185 190
Gln Ser Val Thr Arg Gln Lys Met Gln Gln Leu Glu Gln Met Leu Thr
195 200 205
Ala Leu Asp Gln Met Arg Arg Ser Ile Val Ser Glu Leu Ala Gly Leu
210 215 220
Leu Ser Ala Met Glu Tyr Val Gln Lys Thr Leu Thr Asp Glu Glu Leu
225 230 235 240
Ala Asp Trp Lys Arg Arg Gln Gln Ile Ala Cys Ile Gly Gly Pro Pro
245 250 255
Asn Ile Cys Leu Asp Arg Leu Glu Asn Trp Ile Thr Ser Leu Ala Glu
260 265 270
Ser Gln Leu Gln Thr Arg Gln Gln Ile Lys Lys Leu Glu Glu Leu Gln
275 280 285
Gln Lys Val Ser Tyr Lys Gly Asp Pro Ile Val Gln His Arg Pro Met
290 295 300
Leu Glu Glu Arg Ile Val Glu Leu Phe Arg Asn Leu Met Lys Ser Ala
305 310 315 320
Phe Val Val Glu Arg Gln Pro Cys Met Pro Met His Pro Asp Arg Pro
325 330 335
Leu Val Ile Lys Thr Gly Val Gln Phe Thr Thr Lys Val Arg Leu Leu
340 345 350
Val Lys Phe Pro Glu Leu Asn Tyr Gln Leu Lys Ile Lys Val Cys Ile
355 360 365
Asp Lys Asp Ser Gly Asp Val Ala Ala Leu Arg Gly Ser Arg Lys Phe
370 375 380
Asn Ile Leu Gly Thr Asn Thr Lys Val Met Asn Met Glu Glu Ser Asn
385 390 395 400
Asn Gly Ser Leu Ser Ala Glu Phe Lys His Leu Thr Leu Arg Glu Gln
405 410 415
Arg Cys Gly Asn Gly Gly Arg Ala Asn Cys Asp Ala Ser Leu Ile Val
420 425 430
Thr Glu Glu Leu His Leu Ile Thr Phe Glu Thr Glu Val Tyr His Gln
435 440 445
Gly Leu Lys Ile Asp Leu Glu Thr His Ser Leu Pro Val Val Val Ile
450 455 460
Ser Asn Ile Cys Gln Met Pro Asn Ala Trp Ala Ser Ile Leu Trp Tyr
465 470 475 480
Asn Met Leu Thr Asn Asn Pro Lys Asn Val Asn Phe Phe Thr Lys Pro
485 490 495
Pro Ile Gly Thr Trp Asp Gln Val Ala Glu Val Leu Ser Trp Gln Phe
500 505 510
Ser Ser Thr Thr Lys Arg Gly Leu Ser Ile Glu Gln Leu Thr Thr Leu
515 520 525
Ala Glu Lys Leu Leu Gly Pro Gly Val Asn Tyr Ser Gly Cys Gln Ile
530 535 540
Thr Trp Ala Lys Phe Cys Lys Glu Asn Met Ala Gly Lys Gly Phe Ser
545 550 555 560
Phe Trp Val Trp Leu Asp Asn Ile Ile Asp Leu Val Lys Lys Tyr Ile
565 570 575
Leu Ala Leu Trp Asn Glu Gly Tyr Ile Met Gly Phe Ile Ser Lys Glu
580 585 590
Arg Glu Arg Ala Ile Leu Ser Thr Lys Pro Pro Gly Thr Phe Leu Leu
595 600 605
Arg Phe Ser Glu Ser Ser Lys Glu Gly Gly Val Thr Phe Thr Trp Val
610 615 620
Glu Lys Asp Ile Ser Gly Lys Thr Gln Ile Gln Ser Val Glu Pro Tyr
625 630 635 640
Thr Lys Gln Gln Leu Asn Asn Met Ser Phe Ala Glu Ile Ile Met Gly
645 650 655
Tyr Lys Ile Met Asp Ala Thr Asn Ile Leu Val Ser Pro Leu Val Tyr
660 665 670
Leu Tyr Pro Asp Ile Pro Lys Glu Glu Ala Phe Gly Lys Tyr Cys Arg
675 680 685
Pro Glu Ser Gln Glu His Pro Glu Ala Asp Pro Gly Ser Ala Ala Pro
690 695 700
Tyr Leu Lys Thr Lys Phe Ile Cys Val Thr Pro Thr Thr Cys Ser Asn
705 710 715 720
Thr Ile Asp Leu Pro Met Ser Pro Arg Thr Leu Asp Ser Leu Met Gln
725 730 735
Phe Gly Asn Asn Gly Glu Gly Ala Glu Pro Ser Ala Gly Gly Gln Phe
740 745 750
Glu Ser Leu Thr Phe Asp Met Glu Leu Thr Ser Glu Cys Ala Thr Ser
755 760 765
Pro Met
770
<210> 88
<211> 770
<212> PRT
<213> 小家鼠
<400> 88
Met Ala Gln Trp Asn Gln Leu Gln Gln Leu Asp Thr Arg Tyr Leu Glu
1 5 10 15
Gln Leu His Gln Leu Tyr Ser Asp Ser Phe Pro Met Glu Leu Arg Gln
20 25 30
Phe Leu Ala Pro Trp Ile Glu Ser Gln Asp Trp Ala Tyr Ala Ala Ser
35 40 45
Lys Glu Ser His Ala Thr Leu Val Phe His Asn Leu Leu Gly Glu Ile
50 55 60
Asp Gln Gln Tyr Ser Arg Phe Leu Gln Glu Ser Asn Val Leu Tyr Gln
65 70 75 80
His Asn Leu Arg Arg Ile Lys Gln Phe Leu Gln Ser Arg Tyr Leu Glu
85 90 95
Lys Pro Met Glu Ile Ala Arg Ile Val Ala Arg Cys Leu Trp Glu Glu
100 105 110
Ser Arg Leu Leu Gln Thr Ala Ala Thr Ala Ala Gln Gln Gly Gly Gln
115 120 125
Ala Asn His Pro Thr Ala Ala Val Val Thr Glu Lys Gln Gln Met Leu
130 135 140
Glu Gln His Leu Gln Asp Val Arg Lys Arg Val Gln Asp Leu Glu Gln
145 150 155 160
Lys Met Lys Val Val Glu Asn Leu Gln Asp Asp Phe Asp Phe Asn Tyr
165 170 175
Lys Thr Leu Lys Ser Gln Gly Asp Met Gln Asp Leu Asn Gly Asn Asn
180 185 190
Gln Ser Val Thr Arg Gln Lys Met Gln Gln Leu Glu Gln Met Leu Thr
195 200 205
Ala Leu Asp Gln Met Arg Arg Ser Ile Val Ser Glu Leu Ala Gly Leu
210 215 220
Leu Ser Ala Met Glu Tyr Val Gln Lys Thr Leu Thr Asp Glu Glu Leu
225 230 235 240
Ala Asp Trp Lys Arg Arg Gln Gln Ile Ala Cys Ile Gly Gly Pro Pro
245 250 255
Asn Ile Cys Leu Asp Arg Leu Glu Asn Trp Ile Thr Ser Leu Ala Glu
260 265 270
Ser Gln Leu Gln Thr Arg Gln Gln Ile Lys Lys Leu Glu Glu Leu Gln
275 280 285
Gln Lys Val Ser Tyr Lys Gly Asp Pro Ile Val Gln His Arg Pro Met
290 295 300
Leu Glu Glu Arg Ile Val Glu Leu Phe Arg Asn Leu Met Lys Ser Ala
305 310 315 320
Phe Val Val Glu Arg Gln Pro Cys Met Pro Met His Pro Asp Arg Pro
325 330 335
Leu Val Ile Lys Thr Gly Val Gln Phe Thr Thr Lys Val Arg Leu Leu
340 345 350
Val Lys Phe Pro Glu Leu Asn Tyr Gln Leu Lys Ile Lys Val Cys Ile
355 360 365
Asp Lys Asp Ser Gly Asp Val Ala Ala Leu Arg Gly Ser Arg Lys Phe
370 375 380
Asn Ile Leu Gly Thr Asn Thr Lys Val Met Asn Met Glu Glu Ser Asn
385 390 395 400
Asn Gly Ser Leu Ser Ala Glu Phe Lys His Leu Thr Leu Arg Glu Gln
405 410 415
Arg Cys Gly Asn Gly Gly Arg Ala Asn Cys Asp Ala Ser Leu Ile Val
420 425 430
Thr Glu Glu Leu His Leu Ile Thr Phe Glu Thr Glu Val Tyr His Gln
435 440 445
Gly Leu Lys Ile Asp Leu Glu Thr His Ser Leu Pro Val Val Val Ile
450 455 460
Ser Asn Ile Cys Gln Met Pro Asn Ala Trp Ala Ser Ile Leu Trp Tyr
465 470 475 480
Asn Met Leu Thr Asn Asn Pro Lys Asn Val Asn Phe Phe Thr Lys Pro
485 490 495
Pro Ile Gly Thr Trp Asp Gln Val Ala Glu Val Leu Ser Trp Gln Phe
500 505 510
Ser Ser Thr Thr Lys Arg Gly Leu Ser Ile Glu Gln Leu Thr Thr Leu
515 520 525
Ala Glu Lys Leu Leu Gly Pro Gly Val Asn Tyr Ser Gly Cys Gln Ile
530 535 540
Thr Trp Ala Lys Phe Cys Lys Glu Asn Met Ala Gly Lys Gly Phe Ser
545 550 555 560
Phe Trp Val Trp Leu Asp Asn Ile Ile Asp Leu Val Lys Lys Tyr Ile
565 570 575
Leu Ala Leu Trp Asn Glu Gly Tyr Ile Met Gly Phe Ile Ser Lys Glu
580 585 590
Arg Glu Arg Ala Ile Leu Ser Thr Lys Pro Pro Gly Thr Phe Leu Leu
595 600 605
Arg Phe Ser Glu Ser Ser Lys Glu Gly Gly Val Thr Phe Thr Trp Val
610 615 620
Glu Lys Asp Ile Ser Gly Lys Thr Gln Ile Gln Ser Val Glu Pro Tyr
625 630 635 640
Thr Lys Gln Gln Leu Asn Asn Met Ser Phe Ala Glu Ile Ile Met Gly
645 650 655
Tyr Lys Ile Met Asp Ala Thr Asn Ile Leu Val Ser Pro Leu Val Tyr
660 665 670
Leu Tyr Pro Asp Ile Pro Lys Glu Glu Ala Phe Gly Lys Tyr Cys Arg
675 680 685
Pro Glu Ser Gln Glu His Pro Glu Ala Asp Pro Gly Ser Ala Ala Pro
690 695 700
Tyr Leu Lys Thr Lys Phe Ile Cys Val Thr Pro Thr Thr Cys Ser Asn
705 710 715 720
Thr Ile Asp Leu Pro Met Ser Pro Arg Thr Leu Asp Ser Leu Met Gln
725 730 735
Phe Gly Asn Asn Gly Glu Gly Ala Glu Pro Ser Ala Gly Gly Gln Phe
740 745 750
Glu Ser Leu Thr Phe Asp Met Asp Leu Thr Ser Glu Cys Ala Thr Ser
755 760 765
Pro Met
770
<210> 89
<211> 773
<212> PRT
<213> 智人
<400> 89
Met Phe Ser Lys Arg Leu Glu Lys Ile Pro Gln Val Pro Leu Leu Phe
1 5 10 15
Pro Phe Ile Phe Ile Ile Leu Thr Asn Tyr Ser Lys Met Glu Gly Ala
20 25 30
Val Glu Ser Gln Pro Ser Phe Phe Lys Thr Ser Gln Asp Ile Val Thr
35 40 45
Cys Thr Trp Val Glu Asn Cys Tyr Ser Ser Phe Ser Arg Arg Pro Leu
50 55 60
Glu Gln Met Phe Cys Lys His Gln Ser Lys Asn Ile Ile Ser Trp Thr
65 70 75 80
Gly Met Val Ala His Thr Cys Asn Pro Ser Thr Leu Gly Gly Gln Gly
85 90 95
Leu Cys Asp Phe Ala Lys Met His His Gln Gln Arg Met Ala Ala Leu
100 105 110
Gly Thr Asp Lys Glu Leu Ser Asp Leu Leu Asp Phe Ser Ala Met Phe
115 120 125
Ser Pro Pro Val Ser Ser Gly Lys Asn Gly Pro Thr Ser Leu Ala Ser
130 135 140
Gly His Phe Thr Gly Ser Asn Val Glu Asp Arg Ser Ser Ser Gly Ser
145 150 155 160
Trp Gly Asn Gly Gly His Pro Ser Pro Ser Arg Asn Tyr Gly Asp Gly
165 170 175
Thr Pro Tyr Asp His Met Thr Ser Arg Asp Leu Gly Ser His Asp Asn
180 185 190
Leu Ser Pro Pro Phe Val Asn Ser Arg Ile Gln Ser Lys Thr Glu Arg
195 200 205
Gly Ser Tyr Ser Ser Tyr Gly Arg Glu Ser Asn Leu Gln Gly Cys His
210 215 220
Gln Gln Ser Leu Leu Gly Gly Asp Met Asp Met Gly Asn Pro Gly Thr
225 230 235 240
Leu Ser Pro Thr Lys Pro Gly Ser Gln Tyr Tyr Gln Tyr Ser Ser Asn
245 250 255
Asn Pro Arg Arg Arg Pro Leu His Ser Ser Ala Met Glu Val Gln Thr
260 265 270
Lys Lys Val Arg Lys Val Pro Pro Gly Leu Pro Ser Ser Val Tyr Ala
275 280 285
Pro Ser Ala Ser Thr Ala Asp Tyr Asn Arg Asp Ser Pro Gly Tyr Pro
290 295 300
Ser Ser Lys Pro Ala Thr Ser Thr Phe Pro Ser Ser Phe Phe Met Gln
305 310 315 320
Asp Gly His His Ser Ser Asp Pro Trp Ser Ser Ser Ser Gly Met Asn
325 330 335
Gln Pro Gly Tyr Ala Gly Met Leu Gly Asn Ser Ser His Ile Pro Gln
340 345 350
Ser Ser Ser Tyr Cys Ser Leu His Pro His Glu Arg Leu Ser Tyr Pro
355 360 365
Ser His Ser Ser Ala Asp Ile Asn Ser Ser Leu Pro Pro Met Ser Thr
370 375 380
Phe His Arg Ser Gly Thr Asn His Tyr Ser Thr Ser Ser Cys Thr Pro
385 390 395 400
Pro Ala Asn Gly Thr Asp Ser Ile Met Ala Asn Arg Gly Ser Gly Ala
405 410 415
Ala Gly Ser Ser Gln Thr Gly Asp Ala Leu Gly Lys Ala Leu Ala Ser
420 425 430
Ile Tyr Ser Pro Asp His Thr Asn Asn Ser Phe Ser Ser Asn Pro Ser
435 440 445
Thr Pro Val Gly Ser Pro Pro Ser Leu Ser Ala Gly Thr Ala Val Trp
450 455 460
Ser Arg Asn Gly Gly Gln Ala Ser Ser Ser Pro Asn Tyr Glu Gly Pro
465 470 475 480
Leu His Ser Leu Gln Ser Arg Ile Glu Asp Arg Leu Glu Arg Leu Asp
485 490 495
Asp Ala Ile His Val Leu Arg Asn His Ala Val Gly Pro Ser Thr Ala
500 505 510
Met Pro Gly Gly His Gly Asp Met His Gly Ile Ile Gly Pro Ser His
515 520 525
Asn Gly Ala Met Gly Gly Leu Gly Ser Gly Tyr Gly Thr Gly Leu Leu
530 535 540
Ser Ala Asn Arg His Ser Leu Met Val Gly Thr His Arg Glu Asp Gly
545 550 555 560
Val Ala Leu Arg Gly Ser His Ser Leu Leu Pro Asn Gln Val Pro Val
565 570 575
Pro Gln Leu Pro Val Gln Ser Ala Thr Ser Pro Asp Leu Asn Pro Pro
580 585 590
Gln Asp Pro Tyr Arg Gly Met Pro Pro Gly Leu Gln Gly Gln Ser Val
595 600 605
Ser Ser Gly Ser Ser Glu Ile Lys Ser Asp Asp Glu Gly Asp Glu Asn
610 615 620
Leu Gln Asp Thr Lys Ser Ser Glu Asp Lys Lys Leu Asp Asp Asp Lys
625 630 635 640
Lys Asp Ile Lys Ser Ile Thr Arg Ser Arg Ser Ser Asn Asn Asp Asp
645 650 655
Glu Asp Leu Thr Pro Glu Gln Lys Ala Glu Arg Glu Lys Glu Arg Arg
660 665 670
Met Ala Asn Asn Ala Arg Glu Arg Leu Arg Val Arg Asp Ile Asn Glu
675 680 685
Ala Phe Lys Glu Leu Gly Arg Met Val Gln Leu His Leu Lys Ser Asp
690 695 700
Lys Pro Gln Thr Lys Leu Leu Ile Leu His Gln Ala Val Ala Val Ile
705 710 715 720
Leu Ser Leu Glu Gln Gln Val Arg Glu Arg Asn Leu Asn Pro Lys Ala
725 730 735
Ala Cys Leu Lys Arg Arg Glu Glu Glu Lys Val Ser Ser Glu Pro Pro
740 745 750
Pro Leu Ser Leu Ala Gly Pro His Pro Gly Met Gly Asp Ala Ser Asn
755 760 765
His Met Gly Gln Met
770
<210> 90
<211> 670
<212> PRT
<213> 小家鼠
<400> 90
Met His His Gln Gln Arg Met Ala Ala Leu Gly Thr Asp Lys Glu Leu
1 5 10 15
Ser Asp Leu Leu Asp Phe Ser Ala Met Phe Ser Pro Pro Val Ser Ser
20 25 30
Gly Lys Asn Gly Pro Thr Ser Leu Ala Ser Gly His Phe Thr Gly Ser
35 40 45
Asn Val Glu Asp Arg Ser Ser Ser Gly Ser Trp Gly Thr Gly Gly His
50 55 60
Pro Ser Pro Ser Arg Asn Tyr Gly Asp Gly Thr Pro Tyr Asp His Met
65 70 75 80
Thr Ser Arg Asp Leu Gly Ser His Asp Asn Leu Ser Pro Pro Phe Val
85 90 95
Asn Ser Arg Ile Gln Ser Lys Thr Glu Arg Gly Ser Tyr Ser Ser Tyr
100 105 110
Gly Arg Glu Asn Val Gln Gly Cys His Gln Gln Ser Leu Leu Gly Gly
115 120 125
Asp Met Asp Met Gly Asn Pro Gly Thr Leu Ser Pro Thr Lys Pro Gly
130 135 140
Ser Gln Tyr Tyr Gln Tyr Ser Ser Asn Asn Ala Arg Arg Arg Pro Leu
145 150 155 160
His Ser Ser Ala Met Glu Val Gln Thr Lys Lys Val Arg Lys Val Pro
165 170 175
Pro Gly Leu Pro Ser Ser Val Tyr Ala Pro Ser Ala Ser Thr Ala Asp
180 185 190
Tyr Asn Arg Asp Ser Pro Gly Tyr Pro Ser Ser Lys Pro Ala Ala Ser
195 200 205
Thr Phe Pro Ser Ser Phe Phe Met Gln Asp Gly His His Ser Ser Asp
210 215 220
Pro Trp Ser Ser Ser Ser Gly Met Asn Gln Pro Gly Tyr Gly Gly Met
225 230 235 240
Leu Gly Asn Ser Ser His Ile Pro Gln Ser Ser Ser Tyr Cys Ser Leu
245 250 255
His Pro His Glu Arg Leu Ser Tyr Pro Ser His Ser Ser Ala Asp Ile
260 265 270
Asn Ser Ser Leu Pro Pro Met Ser Thr Phe His Arg Ser Gly Thr Asn
275 280 285
His Tyr Ser Thr Ser Ser Cys Thr Pro Pro Ala Asn Gly Thr Asp Ser
290 295 300
Ile Met Ala Asn Arg Gly Thr Gly Ala Ala Gly Ser Ser Gln Thr Gly
305 310 315 320
Asp Ala Leu Gly Lys Ala Leu Ala Ser Ile Tyr Ser Pro Asp His Thr
325 330 335
Asn Asn Ser Phe Ser Ser Asn Pro Ser Thr Pro Val Gly Ser Pro Pro
340 345 350
Ser Leu Ser Ala Gly Thr Ala Val Trp Ser Arg Asn Gly Gly Gln Ala
355 360 365
Ser Ser Ser Pro Asn Tyr Glu Gly Pro Leu His Ser Leu Gln Ser Arg
370 375 380
Ile Glu Asp Arg Leu Glu Arg Leu Asp Asp Ala Ile His Val Leu Arg
385 390 395 400
Asn His Ala Val Gly Pro Ser Thr Ala Val Pro Gly Gly His Gly Asp
405 410 415
Met His Gly Ile Met Gly Pro Ser His Asn Gly Ala Met Gly Ser Leu
420 425 430
Gly Ser Gly Tyr Gly Thr Ser Leu Leu Ser Ala Asn Arg His Ser Leu
435 440 445
Met Val Gly Ala His Arg Glu Asp Gly Val Ala Leu Arg Gly Ser His
450 455 460
Ser Leu Leu Pro Asn Gln Val Pro Val Pro Gln Leu Pro Val Gln Ser
465 470 475 480
Ala Thr Ser Pro Asp Leu Asn Pro Pro Gln Asp Pro Tyr Arg Gly Met
485 490 495
Pro Pro Gly Leu Gln Gly Gln Ser Val Ser Ser Gly Ser Ser Glu Ile
500 505 510
Lys Ser Asp Asp Glu Gly Asp Glu Asn Leu Gln Asp Thr Lys Ser Ser
515 520 525
Glu Asp Lys Lys Leu Asp Asp Asp Lys Lys Asp Ile Lys Ser Ile Thr
530 535 540
Arg Ser Arg Ser Ser Asn Asn Asp Asp Glu Asp Leu Thr Pro Glu Gln
545 550 555 560
Lys Ala Glu Arg Glu Lys Glu Arg Arg Met Ala Asn Asn Ala Arg Glu
565 570 575
Arg Leu Arg Val Arg Asp Ile Asn Glu Ala Phe Lys Glu Leu Gly Arg
580 585 590
Met Val Gln Leu His Leu Lys Ser Asp Lys Pro Gln Thr Lys Leu Leu
595 600 605
Ile Leu His Gln Ala Val Ala Val Ile Leu Ser Leu Glu Gln Gln Val
610 615 620
Arg Glu Arg Asn Leu Asn Pro Lys Ala Ala Cys Leu Lys Arg Arg Glu
625 630 635 640
Glu Glu Lys Val Ser Ser Glu Pro Pro Pro Leu Ser Leu Ala Gly Pro
645 650 655
His Pro Gly Met Gly Asp Ala Ala Asn His Met Gly Gln Met
660 665 670
<210> 91
<211> 706
<212> PRT
<213> 智人
<400> 91
Met Asn Pro Gln Gln Gln Arg Met Ala Ala Ile Gly Thr Asp Lys Glu
1 5 10 15
Leu Ser Asp Leu Leu Asp Phe Ser Ala Met Phe Ser Pro Pro Val Asn
20 25 30
Ser Gly Lys Thr Arg Pro Thr Thr Leu Gly Ser Ser Gln Phe Ser Gly
35 40 45
Ser Gly Ile Asp Glu Arg Gly Gly Thr Thr Ser Trp Gly Thr Ser Gly
50 55 60
Gln Pro Ser Pro Ser Tyr Asp Ser Ser Arg Gly Phe Thr Asp Ser Pro
65 70 75 80
His Tyr Ser Asp His Leu Asn Asp Ser Arg Leu Gly Ala His Glu Gly
85 90 95
Leu Ser Pro Thr Pro Phe Met Asn Ser Asn Leu Met Gly Lys Thr Ser
100 105 110
Glu Arg Gly Ser Phe Ser Leu Tyr Ser Arg Asp Thr Gly Leu Pro Gly
115 120 125
Cys Gln Ser Ser Leu Leu Arg Gln Asp Leu Gly Leu Gly Ser Pro Ala
130 135 140
Gln Leu Ser Ser Ser Gly Lys Pro Gly Thr Ala Tyr Tyr Ser Phe Ser
145 150 155 160
Ala Thr Ser Ser Arg Arg Arg Pro Leu His Asp Ser Ala Ala Leu Asp
165 170 175
Pro Leu Gln Ala Lys Lys Val Arg Lys Val Pro Pro Gly Leu Pro Ser
180 185 190
Ser Val Tyr Ala Pro Ser Pro Asn Ser Asp Asp Phe Asn Arg Glu Ser
195 200 205
Pro Ser Tyr Pro Ser Pro Lys Pro Pro Thr Ser Met Phe Ala Ser Thr
210 215 220
Phe Phe Met Gln Asp Gly Thr His Asn Ser Ser Asp Leu Trp Ser Ser
225 230 235 240
Ser Asn Gly Met Ser Gln Pro Gly Phe Gly Gly Ile Leu Gly Thr Ser
245 250 255
Thr Ser His Met Ser Gln Ser Ser Ser Tyr Gly Asn Leu His Ser His
260 265 270
Asp Arg Leu Ser Tyr Pro Pro His Ser Val Ser Pro Thr Asp Ile Asn
275 280 285
Thr Ser Leu Pro Pro Met Ser Ser Phe His Arg Gly Ser Thr Ser Ser
290 295 300
Ser Pro Tyr Val Ala Ala Ser His Thr Pro Pro Ile Asn Gly Ser Asp
305 310 315 320
Ser Ile Leu Gly Thr Arg Gly Asn Ala Ala Gly Ser Ser Gln Thr Gly
325 330 335
Asp Ala Leu Gly Lys Ala Leu Ala Ser Ile Tyr Ser Pro Asp His Thr
340 345 350
Ser Ser Ser Phe Pro Ser Asn Pro Ser Thr Pro Val Gly Ser Pro Ser
355 360 365
Pro Leu Thr Gly Thr Ser Gln Trp Pro Arg Pro Gly Gly Gln Ala Pro
370 375 380
Ser Ser Pro Ser Tyr Glu Asn Ser Leu His Ser Leu Lys Asn Arg Val
385 390 395 400
Glu Gln Gln Leu His Glu His Leu Gln Asp Ala Met Ser Phe Leu Lys
405 410 415
Asp Val Cys Glu Gln Ser Arg Met Glu Asp Arg Leu Asp Arg Leu Asp
420 425 430
Asp Ala Ile His Val Leu Arg Asn His Ala Val Gly Pro Ser Thr Ser
435 440 445
Leu Pro Ala Gly His Ser Asp Ile His Ser Leu Leu Gly Pro Ser His
450 455 460
Asn Ala Pro Ile Gly Ser Leu Asn Ser Asn Tyr Gly Gly Ser Ser Leu
465 470 475 480
Val Ala Ser Ser Arg Ser Ala Ser Met Val Gly Thr His Arg Glu Asp
485 490 495
Ser Val Ser Leu Asn Gly Asn His Ser Val Leu Ser Ser Thr Val Thr
500 505 510
Thr Ser Ser Thr Asp Leu Asn His Lys Thr Gln Glu Asn Tyr Arg Gly
515 520 525
Gly Leu Gln Ser Gln Ser Gly Thr Val Val Thr Thr Glu Ile Lys Thr
530 535 540
Glu Asn Lys Glu Lys Asp Glu Asn Leu His Glu Pro Pro Ser Ser Asp
545 550 555 560
Asp Met Lys Ser Asp Asp Glu Ser Ser Gln Lys Asp Ile Lys Val Ser
565 570 575
Ser Arg Gly Arg Thr Ser Ser Thr Asn Glu Asp Glu Asp Leu Asn Pro
580 585 590
Glu Gln Lys Ile Glu Arg Glu Lys Glu Arg Arg Met Ala Asn Asn Ala
595 600 605
Arg Glu Arg Leu Arg Val Arg Asp Ile Asn Glu Ala Phe Lys Glu Leu
610 615 620
Gly Arg Met Cys Gln Leu His Leu Lys Ser Glu Lys Pro Gln Thr Lys
625 630 635 640
Leu Leu Ile Leu His Gln Ala Val Ala Val Ile Leu Ser Leu Glu Gln
645 650 655
Gln Val Arg Glu Arg Asn Leu Asn Pro Lys Ala Ala Cys Leu Lys Arg
660 665 670
Arg Glu Glu Glu Lys Val Ser Ala Val Ser Ala Glu Pro Pro Thr Thr
675 680 685
Leu Pro Gly Thr His Pro Gly Leu Ser Glu Thr Thr Asn Pro Met Gly
690 695 700
His Met
705
<210> 92
<211> 706
<212> PRT
<213> 小家鼠
<400> 92
Met Asn Pro Gln Gln Gln Arg Met Ala Ala Ile Gly Thr Asp Lys Glu
1 5 10 15
Leu Ser Asp Leu Leu Asp Phe Ser Ala Met Phe Ser Pro Pro Val Asn
20 25 30
Ser Gly Lys Thr Arg Pro Thr Thr Leu Gly Ser Ser Gln Phe Ser Gly
35 40 45
Ser Gly Met Asp Glu Arg Gly Gly Thr Thr Ser Trp Gly Thr Ser Gly
50 55 60
Gln Pro Ser Pro Ser Tyr Asp Ser Ser Arg Gly Phe Thr Asp Ser Pro
65 70 75 80
His Tyr Ser Asp His Leu Asn Asp Ser Arg Leu Gly Thr His Glu Gly
85 90 95
Leu Ser Pro Thr Pro Phe Met Asn Ser Asn Leu Ile Gly Lys Thr Ser
100 105 110
Glu Arg Gly Ser Phe Ser Leu Tyr Ser Arg Asp Ser Gly Leu Ser Gly
115 120 125
Cys Gln Ser Ser Leu Leu Arg Gln Asp Leu Gly Leu Gly Ser Pro Ala
130 135 140
Gln Leu Ser Ser Ser Gly Lys Pro Gly Thr Pro Tyr Tyr Ser Phe Ser
145 150 155 160
Ala Thr Ser Ser Arg Arg Arg Pro Leu His Asp Ser Val Ala Leu Asp
165 170 175
Pro Leu Gln Ala Lys Lys Val Arg Lys Val Pro Pro Gly Leu Pro Ser
180 185 190
Ser Val Tyr Ala Pro Ser Pro Asn Ser Asp Asp Phe Asn Arg Glu Ser
195 200 205
Pro Ser Tyr Pro Ser Pro Lys Pro Pro Thr Ser Met Phe Ala Ser Thr
210 215 220
Phe Phe Met Gln Asp Gly Thr His Ser Ser Ser Asp Leu Trp Ser Ser
225 230 235 240
Ser Asn Gly Met Ser Gln Pro Gly Phe Gly Gly Ile Leu Gly Thr Ser
245 250 255
Thr Ser His Met Ser Gln Ser Ser Ser Tyr Gly Ser Leu His Ser His
260 265 270
Asp Arg Leu Ser Tyr Pro Pro His Ser Val Ser Pro Thr Asp Ile Asn
275 280 285
Thr Ser Leu Pro Pro Met Ser Ser Phe His Arg Gly Ser Thr Ser Ser
290 295 300
Ser Pro Tyr Val Ala Ala Ser His Thr Pro Pro Ile Asn Gly Ser Asp
305 310 315 320
Ser Ile Leu Gly Thr Arg Gly Asn Ala Ala Gly Ser Ser Gln Thr Gly
325 330 335
Asp Ala Leu Gly Lys Ala Leu Ala Ser Ile Tyr Ser Pro Asp His Thr
340 345 350
Ser Ser Ser Phe Pro Ser Asn Pro Ser Thr Pro Val Gly Ser Pro Ser
355 360 365
Pro Leu Thr Gly Thr Ser Gln Trp Pro Arg Ala Gly Gly Gln Ala Pro
370 375 380
Ser Ser Pro Ser Tyr Glu Asn Ser Leu His Ser Leu Lys Asn Arg Val
385 390 395 400
Glu Gln Gln Leu His Glu His Leu Gln Asp Ala Met Ser Phe Leu Lys
405 410 415
Asp Val Cys Glu Gln Ser Arg Met Glu Asp Arg Leu Asp Arg Leu Asp
420 425 430
Asp Ala Ile His Val Leu Arg Asn His Ala Val Gly Pro Ser Thr Ser
435 440 445
Leu Pro Thr Ser His Ser Asp Ile His Ser Leu Leu Gly Pro Ser His
450 455 460
Asn Ala Ser Ile Gly Asn Leu Asn Ser Asn Tyr Gly Gly Ser Ser Leu
465 470 475 480
Val Thr Asn Ser Arg Ser Ala Ser Met Val Gly Thr His Arg Glu Asp
485 490 495
Ser Val Ser Leu Asn Gly Asn His Ser Val Leu Ser Ser Thr Val Ala
500 505 510
Ala Ser Asn Thr Glu Leu Asn His Lys Thr Pro Glu Asn Phe Arg Gly
515 520 525
Gly Val Gln Asn Gln Ser Gly Ser Val Val Pro Thr Glu Ile Lys Thr
530 535 540
Glu Asn Lys Glu Lys Asp Glu Asn Leu His Glu Pro Pro Ser Ser Asp
545 550 555 560
Asp Met Lys Ser Asp Asp Glu Ser Ser Gln Lys Asp Ile Lys Val Ser
565 570 575
Ser Arg Gly Arg Thr Ser Ser Thr Asn Glu Asp Glu Asp Leu Asn Pro
580 585 590
Glu Gln Lys Ile Glu Arg Glu Lys Glu Arg Arg Met Ala Asn Asn Ala
595 600 605
Arg Glu Arg Leu Arg Val Arg Asp Ile Asn Glu Ala Phe Lys Glu Leu
610 615 620
Gly Arg Met Cys Gln Leu His Leu Lys Ser Glu Lys Pro Gln Thr Lys
625 630 635 640
Leu Leu Ile Leu His Gln Ala Val Ala Val Ile Leu Ser Leu Glu Gln
645 650 655
Gln Val Arg Glu Arg Asn Leu Asn Pro Lys Ala Ala Cys Leu Lys Arg
660 665 670
Arg Glu Glu Glu Lys Val Ser Ala Ala Ser Ala Glu Pro Pro Asn Thr
675 680 685
Leu Pro Gly Ala His Pro Gly Leu Ser Glu Ser Thr Asn Pro Met Gly
690 695 700
His Leu
705
<210> 93
<211> 750
<212> PRT
<213> 智人
<400> 93
Met Ser Gln Trp Tyr Glu Leu Gln Gln Leu Asp Ser Lys Phe Leu Glu
1 5 10 15
Gln Val His Gln Leu Tyr Asp Asp Ser Phe Pro Met Glu Ile Arg Gln
20 25 30
Tyr Leu Ala Gln Trp Leu Glu Lys Gln Asp Trp Glu His Ala Ala Asn
35 40 45
Asp Val Ser Phe Ala Thr Ile Arg Phe His Asp Leu Leu Ser Gln Leu
50 55 60
Asp Asp Gln Tyr Ser Arg Phe Ser Leu Glu Asn Asn Phe Leu Leu Gln
65 70 75 80
His Asn Ile Arg Lys Ser Lys Arg Asn Leu Gln Asp Asn Phe Gln Glu
85 90 95
Asp Pro Ile Gln Met Ser Met Ile Ile Tyr Ser Cys Leu Lys Glu Glu
100 105 110
Arg Lys Ile Leu Glu Asn Ala Gln Arg Phe Asn Gln Ala Gln Ser Gly
115 120 125
Asn Ile Gln Ser Thr Val Met Leu Asp Lys Gln Lys Glu Leu Asp Ser
130 135 140
Lys Val Arg Asn Val Lys Asp Lys Val Met Cys Ile Glu His Glu Ile
145 150 155 160
Lys Ser Leu Glu Asp Leu Gln Asp Glu Tyr Asp Phe Lys Cys Lys Thr
165 170 175
Leu Gln Asn Arg Glu His Glu Thr Asn Gly Val Ala Lys Ser Asp Gln
180 185 190
Lys Gln Glu Gln Leu Leu Leu Lys Lys Met Tyr Leu Met Leu Asp Asn
195 200 205
Lys Arg Lys Glu Val Val His Lys Ile Ile Glu Leu Leu Asn Val Thr
210 215 220
Glu Leu Thr Gln Asn Ala Leu Ile Asn Asp Glu Leu Val Glu Trp Lys
225 230 235 240
Arg Arg Gln Gln Ser Ala Cys Ile Gly Gly Pro Pro Asn Ala Cys Leu
245 250 255
Asp Gln Leu Gln Asn Trp Phe Thr Ile Val Ala Glu Ser Leu Gln Gln
260 265 270
Val Arg Gln Gln Leu Lys Lys Leu Glu Glu Leu Glu Gln Lys Tyr Thr
275 280 285
Tyr Glu His Asp Pro Ile Thr Lys Asn Lys Gln Val Leu Trp Asp Arg
290 295 300
Thr Phe Ser Leu Phe Gln Gln Leu Ile Gln Ser Ser Phe Val Val Glu
305 310 315 320
Arg Gln Pro Cys Met Pro Thr His Pro Gln Arg Pro Leu Val Leu Lys
325 330 335
Thr Gly Val Gln Phe Thr Val Lys Leu Arg Leu Leu Val Lys Leu Gln
340 345 350
Glu Leu Asn Tyr Asn Leu Lys Val Lys Val Leu Phe Asp Lys Asp Val
355 360 365
Asn Glu Arg Asn Thr Val Lys Gly Phe Arg Lys Phe Asn Ile Leu Gly
370 375 380
Thr His Thr Lys Val Met Asn Met Glu Glu Ser Thr Asn Gly Ser Leu
385 390 395 400
Ala Ala Glu Phe Arg His Leu Gln Leu Lys Glu Gln Lys Asn Ala Gly
405 410 415
Thr Arg Thr Asn Glu Gly Pro Leu Ile Val Thr Glu Glu Leu His Ser
420 425 430
Leu Ser Phe Glu Thr Gln Leu Cys Gln Pro Gly Leu Val Ile Asp Leu
435 440 445
Glu Thr Thr Ser Leu Pro Val Val Val Ile Ser Asn Val Ser Gln Leu
450 455 460
Pro Ser Gly Trp Ala Ser Ile Leu Trp Tyr Asn Met Leu Val Ala Glu
465 470 475 480
Pro Arg Asn Leu Ser Phe Phe Leu Thr Pro Pro Cys Ala Arg Trp Ala
485 490 495
Gln Leu Ser Glu Val Leu Ser Trp Gln Phe Ser Ser Val Thr Lys Arg
500 505 510
Gly Leu Asn Val Asp Gln Leu Asn Met Leu Gly Glu Lys Leu Leu Gly
515 520 525
Pro Asn Ala Ser Pro Asp Gly Leu Ile Pro Trp Thr Arg Phe Cys Lys
530 535 540
Glu Asn Ile Asn Asp Lys Asn Phe Pro Phe Trp Leu Trp Ile Glu Ser
545 550 555 560
Ile Leu Glu Leu Ile Lys Lys His Leu Leu Pro Leu Trp Asn Asp Gly
565 570 575
Cys Ile Met Gly Phe Ile Ser Lys Glu Arg Glu Arg Ala Leu Leu Lys
580 585 590
Asp Gln Gln Pro Gly Thr Phe Leu Leu Arg Phe Ser Glu Ser Ser Arg
595 600 605
Glu Gly Ala Ile Thr Phe Thr Trp Val Glu Arg Ser Gln Asn Gly Gly
610 615 620
Glu Pro Asp Phe His Ala Val Glu Pro Tyr Thr Lys Lys Glu Leu Ser
625 630 635 640
Ala Val Thr Phe Pro Asp Ile Ile Arg Asn Tyr Lys Val Met Ala Ala
645 650 655
Glu Asn Ile Pro Glu Asn Pro Leu Lys Tyr Leu Tyr Pro Asn Ile Asp
660 665 670
Lys Asp His Ala Phe Gly Lys Tyr Tyr Ser Arg Pro Lys Glu Ala Pro
675 680 685
Glu Pro Met Glu Leu Asp Gly Pro Lys Gly Thr Gly Tyr Ile Lys Thr
690 695 700
Glu Leu Ile Ser Val Ser Glu Val His Pro Ser Arg Leu Gln Thr Thr
705 710 715 720
Asp Asn Leu Leu Pro Met Ser Pro Glu Glu Phe Asp Glu Val Ser Arg
725 730 735
Ile Val Gly Ser Val Glu Phe Asp Ser Met Met Asn Thr Val
740 745 750
<210> 94
<211> 755
<212> PRT
<213> 小家鼠
<400> 94
Met Ser Gln Trp Phe Glu Leu Gln Gln Leu Asp Ser Lys Phe Leu Glu
1 5 10 15
Gln Val His Gln Leu Tyr Asp Asp Ser Phe Pro Met Glu Ile Arg Gln
20 25 30
Tyr Leu Ala Gln Trp Leu Glu Lys Gln Asp Trp Glu His Ala Ala Tyr
35 40 45
Asp Val Ser Phe Ala Thr Ile Arg Phe His Asp Leu Leu Ser Gln Leu
50 55 60
Asp Asp Gln Tyr Ser Arg Phe Ser Leu Glu Asn Asn Phe Leu Leu Gln
65 70 75 80
His Asn Ile Arg Lys Ser Lys Arg Asn Leu Gln Asp Asn Phe Gln Glu
85 90 95
Asp Pro Val Gln Met Ser Met Ile Ile Tyr Asn Cys Leu Lys Glu Glu
100 105 110
Arg Lys Ile Leu Glu Asn Ala Gln Arg Phe Asn Gln Ala Gln Glu Gly
115 120 125
Asn Ile Gln Asn Thr Val Met Leu Asp Lys Gln Lys Glu Leu Asp Ser
130 135 140
Lys Val Arg Asn Val Lys Asp Gln Val Met Cys Ile Glu Gln Glu Ile
145 150 155 160
Lys Thr Leu Glu Glu Leu Gln Asp Glu Tyr Asp Phe Lys Cys Lys Thr
165 170 175
Ser Gln Asn Arg Glu Gly Glu Ala Asn Gly Val Ala Lys Ser Asp Gln
180 185 190
Lys Gln Glu Gln Leu Leu Leu His Lys Met Phe Leu Met Leu Asp Asn
195 200 205
Lys Arg Lys Glu Ile Ile His Lys Ile Arg Glu Leu Leu Asn Ser Ile
210 215 220
Glu Leu Thr Gln Asn Thr Leu Ile Asn Asp Glu Leu Val Glu Trp Lys
225 230 235 240
Arg Arg Gln Gln Ser Ala Cys Ile Gly Gly Pro Pro Asn Ala Cys Leu
245 250 255
Asp Gln Leu Gln Ser Trp Phe Thr Ile Val Ala Glu Thr Leu Gln Gln
260 265 270
Ile Arg Gln Gln Leu Lys Lys Leu Glu Glu Leu Glu Gln Lys Phe Thr
275 280 285
Tyr Glu Pro Asp Pro Ile Thr Lys Asn Lys Gln Val Leu Ser Asp Arg
290 295 300
Thr Phe Leu Leu Phe Gln Gln Leu Ile Gln Ser Ser Phe Val Val Glu
305 310 315 320
Arg Gln Pro Cys Met Pro Thr His Pro Gln Arg Pro Leu Val Leu Lys
325 330 335
Thr Gly Val Gln Phe Thr Val Lys Leu Arg Leu Leu Val Lys Leu Gln
340 345 350
Glu Leu Asn Tyr Asn Leu Lys Val Lys Val Ser Phe Asp Lys Asp Val
355 360 365
Asn Glu Lys Asn Thr Val Lys Gly Phe Arg Lys Phe Asn Ile Leu Gly
370 375 380
Thr His Thr Lys Val Met Asn Met Glu Glu Ser Thr Asn Gly Ser Leu
385 390 395 400
Ala Ala Glu Phe Arg His Leu Gln Leu Lys Glu Gln Lys Asn Ala Gly
405 410 415
Asn Arg Thr Asn Glu Gly Pro Leu Ile Val Thr Glu Glu Leu His Ser
420 425 430
Leu Ser Phe Glu Thr Gln Leu Cys Gln Pro Gly Leu Val Ile Asp Leu
435 440 445
Glu Val Phe Val Pro Phe Gln Thr Thr Ser Leu Pro Val Val Val Ile
450 455 460
Ser Asn Val Ser Gln Leu Pro Ser Gly Trp Ala Ser Ile Leu Trp Tyr
465 470 475 480
Asn Met Leu Val Thr Glu Pro Arg Asn Leu Ser Phe Phe Leu Asn Pro
485 490 495
Pro Cys Ala Trp Trp Ser Gln Leu Ser Glu Val Leu Ser Trp Gln Phe
500 505 510
Ser Ser Val Thr Lys Arg Gly Leu Asn Ala Asp Gln Leu Ser Met Leu
515 520 525
Gly Glu Lys Leu Leu Gly Pro Asn Ala Gly Pro Asp Gly Leu Ile Pro
530 535 540
Trp Thr Arg Phe Cys Lys Glu Asn Ile Asn Asp Lys Asn Phe Ser Phe
545 550 555 560
Trp Pro Trp Ile Asp Thr Ile Leu Glu Leu Ile Lys Lys His Leu Leu
565 570 575
Cys Leu Trp Asn Asp Gly Cys Ile Met Gly Phe Ile Ser Lys Glu Arg
580 585 590
Glu Arg Ala Leu Leu Lys Asp Gln Gln Pro Gly Thr Phe Leu Leu Arg
595 600 605
Phe Ser Glu Ser Ser Arg Glu Gly Ala Ile Thr Phe Thr Trp Val Glu
610 615 620
Arg Ser Gln Asn Gly Gly Glu Pro Asp Phe His Ala Val Glu Pro Tyr
625 630 635 640
Thr Lys Lys Glu Leu Ser Ala Val Thr Phe Pro Asp Ile Ile Arg Asn
645 650 655
Tyr Lys Val Met Ala Ala Glu Asn Ile Pro Glu Asn Pro Leu Lys Tyr
660 665 670
Leu Tyr Pro Asn Ile Asp Lys Asp His Ala Phe Gly Lys Tyr Tyr Ser
675 680 685
Arg Pro Lys Glu Ala Pro Glu Pro Met Glu Leu Asp Asp Pro Lys Arg
690 695 700
Thr Gly Tyr Ile Lys Thr Glu Leu Ile Ser Val Ser Glu Val His Pro
705 710 715 720
Ser Arg Leu Gln Thr Thr Asp Asn Leu Leu Pro Met Ser Pro Glu Glu
725 730 735
Phe Asp Glu Met Ser Arg Ile Val Gly Pro Glu Phe Asp Ser Met Met
740 745 750
Ser Thr Val
755
<210> 95
<211> 1073
<212> PRT
<213> 智人
<400> 95
Met His Gln Pro Pro Glu Ser Thr Ala Ala Ala Ala Ala Ala Ala Asp
1 5 10 15
Ile Ser Ala Arg Lys Met Ala His Pro Ala Met Phe Pro Arg Arg Gly
20 25 30
Ser Gly Ser Gly Ser Ala Ser Ala Leu Asn Ala Ala Gly Thr Gly Val
35 40 45
Gly Ser Asn Ala Thr Ser Ser Glu Asp Phe Pro Pro Pro Ser Leu Leu
50 55 60
Gln Pro Pro Pro Pro Ala Ala Ser Ser Thr Ser Gly Pro Gln Pro Pro
65 70 75 80
Pro Pro Gln Ser Leu Asn Leu Leu Ser Gln Ala Gln Leu Gln Ala Gln
85 90 95
Pro Leu Ala Pro Gly Gly Thr Gln Met Lys Lys Lys Ser Gly Phe Gln
100 105 110
Ile Thr Ser Val Thr Pro Ala Gln Ile Ser Ala Ser Ile Ser Ser Asn
115 120 125
Asn Ser Ile Ala Glu Asp Thr Glu Ser Tyr Asp Asp Leu Asp Glu Ser
130 135 140
His Thr Glu Asp Leu Ser Ser Ser Glu Ile Leu Asp Val Ser Leu Ser
145 150 155 160
Arg Ala Thr Asp Leu Gly Glu Pro Glu Arg Ser Ser Ser Glu Glu Thr
165 170 175
Leu Asn Asn Phe Gln Glu Ala Glu Thr Pro Gly Ala Val Ser Pro Asn
180 185 190
Gln Pro His Leu Pro Gln Pro His Leu Pro His Leu Pro Gln Gln Asn
195 200 205
Val Val Ile Asn Gly Asn Ala His Pro His His Leu His His His His
210 215 220
Gln Ile His His Gly His His Leu Gln His Gly His His His Pro Ser
225 230 235 240
His Val Ala Val Ala Ser Ala Ser Ile Thr Gly Gly Pro Pro Ser Ser
245 250 255
Pro Val Ser Arg Lys Leu Ser Thr Thr Gly Ser Ser Asp Ser Ile Thr
260 265 270
Pro Val Ala Pro Thr Ser Ala Val Ser Ser Ser Gly Ser Pro Ala Ser
275 280 285
Val Met Thr Asn Met Arg Ala Pro Ser Thr Thr Gly Gly Ile Gly Ile
290 295 300
Asn Ser Val Thr Gly Thr Ser Thr Val Asn Asn Val Asn Ile Thr Ala
305 310 315 320
Val Gly Ser Phe Asn Pro Asn Val Thr Ser Ser Met Leu Gly Asn Val
325 330 335
Asn Ile Ser Thr Ser Asn Ile Pro Ser Ala Ala Gly Val Ser Val Gly
340 345 350
Pro Gly Val Thr Ser Gly Val Asn Val Asn Ile Leu Ser Gly Met Gly
355 360 365
Asn Gly Thr Ile Ser Ser Ser Ala Ala Val Ser Ser Val Pro Asn Ala
370 375 380
Ala Ala Gly Met Thr Gly Gly Ser Val Ser Ser Gln Gln Gln Gln Pro
385 390 395 400
Thr Val Asn Thr Ser Arg Phe Arg Val Val Lys Leu Asp Ser Ser Ser
405 410 415
Glu Pro Phe Lys Lys Gly Arg Trp Thr Cys Thr Glu Phe Tyr Glu Lys
420 425 430
Glu Asn Ala Val Pro Ala Thr Glu Gly Val Leu Ile Asn Lys Val Val
435 440 445
Glu Thr Val Lys Gln Asn Pro Ile Glu Val Thr Ser Glu Arg Glu Ser
450 455 460
Thr Ser Gly Ser Ser Val Ser Ser Ser Val Ser Thr Leu Ser His Tyr
465 470 475 480
Thr Glu Ser Val Gly Ser Gly Glu Met Gly Ala Pro Thr Val Val Val
485 490 495
Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Pro Ala Leu
500 505 510
Gln Gly Val Thr Leu Gln Gln Met Asp Phe Gly Ser Thr Gly Pro Gln
515 520 525
Ser Ile Pro Ala Val Ser Ile Pro Gln Ser Ile Ser Gln Ser Gln Ile
530 535 540
Ser Gln Val Gln Leu Gln Ser Gln Glu Leu Ser Tyr Gln Gln Lys Gln
545 550 555 560
Gly Leu Gln Pro Val Pro Leu Gln Ala Thr Met Ser Ala Ala Thr Gly
565 570 575
Ile Gln Pro Ser Pro Val Asn Val Val Gly Val Thr Ser Ala Leu Gly
580 585 590
Gln Gln Pro Ser Ile Ser Ser Leu Ala Gln Pro Gln Leu Pro Tyr Ser
595 600 605
Gln Ala Ala Pro Pro Val Gln Thr Pro Leu Pro Gly Ala Pro Pro Pro
610 615 620
Gln Gln Leu Gln Tyr Gly Gln Gln Gln Pro Met Val Ser Thr Gln Met
625 630 635 640
Ala Pro Gly His Val Lys Ser Val Thr Gln Asn Pro Ala Ser Glu Tyr
645 650 655
Val Gln Gln Gln Pro Ile Leu Gln Thr Ala Met Ser Ser Gly Gln Pro
660 665 670
Ser Ser Ala Gly Val Gly Ala Gly Thr Thr Val Ile Pro Val Ala Gln
675 680 685
Pro Gln Gly Ile Gln Leu Pro Val Gln Pro Thr Ala Val Pro Ala Gln
690 695 700
Pro Ala Gly Ala Ser Val Gln Pro Val Gly Gln Ala Pro Ala Ala Val
705 710 715 720
Ser Ala Val Pro Thr Gly Ser Gln Ile Ala Asn Ile Gly Gln Gln Ala
725 730 735
Asn Ile Pro Thr Ala Val Gln Gln Pro Ser Thr Gln Val Pro Pro Ser
740 745 750
Val Ile Gln Gln Gly Ala Pro Pro Ser Ser Gln Val Val Pro Pro Ala
755 760 765
Gln Thr Gly Ile Ile His Gln Gly Val Gln Thr Ser Ala Pro Ser Leu
770 775 780
Pro Gln Gln Leu Val Ile Ala Ser Gln Ser Ser Leu Leu Thr Val Pro
785 790 795 800
Pro Gln Pro Gln Gly Val Glu Pro Val Ala Gln Gly Ile Val Ser Gln
805 810 815
Gln Leu Pro Ala Val Ser Ser Leu Pro Ser Ala Ser Ser Ile Ser Val
820 825 830
Thr Ser Gln Val Ser Ser Thr Gly Pro Ser Gly Met Pro Ser Ala Pro
835 840 845
Thr Asn Leu Val Pro Pro Gln Asn Ile Ala Gln Thr Pro Ala Thr Gln
850 855 860
Asn Gly Asn Leu Val Gln Ser Val Ser Gln Pro Pro Leu Ile Ala Thr
865 870 875 880
Asn Thr Asn Leu Pro Leu Ala Gln Gln Ile Pro Leu Ser Ser Thr Gln
885 890 895
Phe Ser Ala Gln Ser Leu Ala Gln Ala Ile Gly Ser Gln Ile Glu Asp
900 905 910
Ala Arg Arg Ala Ala Glu Pro Ser Leu Val Gly Leu Pro Gln Thr Ile
915 920 925
Ser Gly Asp Ser Gly Gly Met Ser Ala Val Ser Asp Gly Ser Ser Ser
930 935 940
Ser Leu Ala Ala Ser Ala Ser Leu Phe Pro Leu Lys Val Leu Pro Leu
945 950 955 960
Thr Thr Pro Leu Val Asp Gly Glu Asp Glu Ser Ser Ser Gly Ala Ser
965 970 975
Val Val Ala Ile Asp Asn Lys Ile Glu Gln Ala Met Asp Leu Val Lys
980 985 990
Ser His Leu Met Tyr Ala Val Arg Glu Glu Val Glu Val Leu Lys Glu
995 1000 1005
Gln Ile Lys Glu Leu Ile Glu Lys Asn Ser Gln Leu Glu Gln Glu
1010 1015 1020
Asn Asn Leu Leu Lys Thr Leu Ala Ser Pro Glu Gln Leu Ala Gln
1025 1030 1035
Phe Gln Ala Gln Leu Gln Thr Gly Ser Pro Pro Ala Thr Thr Gln
1040 1045 1050
Pro Gln Gly Thr Thr Gln Pro Pro Ala Gln Pro Ala Ser Gln Gly
1055 1060 1065
Ser Gly Pro Thr Ala
1070
<210> 96
<211> 1077
<212> PRT
<213> 小家鼠
<400> 96
Met His Gln Pro Pro Glu Ser Thr Ala Ala Ala Ala Ala Ala Ala Asp
1 5 10 15
Ile Ser Ala Arg Lys Met Ala His Pro Ala Met Phe Pro Arg Arg Gly
20 25 30
Ser Gly Gly Gly Ser Ala Ser Ala Leu Asn Ala Ala Gly Thr Gly Val
35 40 45
Ser Gly Ala Ala Pro Ser Ser Glu Asp Phe Pro Pro Pro Ser Leu Leu
50 55 60
Gln Pro Pro Pro Pro Ala Ala Ser Ser Thr Gln Gly Pro Gln Pro Pro
65 70 75 80
Pro Pro Gln Ser Leu Asn Leu Leu Ser Gln Ala Gln Leu Gln Gly Gln
85 90 95
Pro Leu Ala Pro Gly Gly Thr Gln Met Lys Lys Lys Ser Gly Phe Gln
100 105 110
Ile Thr Ser Val Thr Pro Ala Gln Ile Ser Ala Ser Ile Ser Ser Asn
115 120 125
Asn Ser Ile Ala Glu Asp Thr Glu Ser Tyr Asp Asp Leu Asp Glu Ser
130 135 140
His Thr Glu Asp Leu Ser Ser Ser Glu Ile Leu Asp Val Ser Leu Ser
145 150 155 160
Arg Ala Thr Asp Leu Gly Glu Pro Glu Arg Ser Ser Ser Glu Glu Thr
165 170 175
Leu Asn Asn Phe Gln Glu Ala Glu Thr Pro Gly Ala Val Ser Pro Asn
180 185 190
Gln Pro His Leu Pro Gln Pro His Leu Pro His Leu Pro Gln Gln Asn
195 200 205
Val Val Ile Asn Gly Asn Ala His Pro His His Leu His His His His
210 215 220
His Pro His His Gly His His Leu His His Gly His His His Ser Ser
225 230 235 240
His Ala Ala Val Ala Gly Pro Ser Ile Pro Gly Gly Pro Pro Ser Ser
245 250 255
Pro Val Ser Arg Lys Leu Ser Thr Thr Gly Ser Ser Asp Gly Gly Val
260 265 270
Pro Val Ala Pro Pro Pro Ala Val Pro Ser Ser Gly Leu Pro Ala Ser
275 280 285
Val Met Thr Asn Ile Arg Thr Pro Ser Thr Thr Gly Ser Leu Gly Ile
290 295 300
Asn Ser Val Thr Gly Thr Ser Ala Thr Asn Asn Val Asn Ile Ala Ala
305 310 315 320
Val Gly Ser Phe Ser Pro Ser Val Thr Asn Ser Val His Gly Asn Ala
325 330 335
Asn Ile Asn Thr Ser Asn Ile Pro Asn Ala Ala Ser Ile Ser Gly Gly
340 345 350
Pro Gly Val Thr Ser Val Val Asn Ser Ser Ile Leu Ser Gly Met Gly
355 360 365
Asn Gly Thr Val Ser Ser Ser Pro Val Ala Asn Ser Val Leu Asn Ala
370 375 380
Ala Ala Gly Ile Thr Val Gly Val Val Ser Ser Gln Gln Gln Gln Gln
385 390 395 400
Gln Gln Gln Gln Pro Thr Val Asn Thr Ser Arg Phe Arg Val Val Lys
405 410 415
Leu Asp Ser Thr Ser Glu Pro Phe Lys Lys Gly Arg Trp Thr Cys Thr
420 425 430
Glu Phe Tyr Glu Lys Glu Asn Ala Val Pro Ala Thr Glu Gly Val Ala
435 440 445
Val Asn Lys Val Val Glu Thr Val Lys Gln Thr Pro Thr Glu Ala Ser
450 455 460
Ser Ser Glu Arg Glu Ser Thr Ser Gly Ser Ser Val Ser Ser Ser Val
465 470 475 480
Ser Thr Leu Ser His Tyr Thr Glu Ser Val Gly Ser Gly Glu Met Met
485 490 495
Gly Ala Pro Ala Val Val Ala Pro Gln Gln Pro Pro Leu Pro Pro Ala
500 505 510
Pro Pro Gly Leu Gln Gly Val Ala Leu Gln Gln Leu Glu Phe Ser Ser
515 520 525
Pro Ala Pro Gln Ser Ile Ala Ala Val Ser Met Pro Gln Ser Ile Ser
530 535 540
Gln Ser Gln Met Ser Gln Val Gln Leu Gln Pro Gln Glu Leu Ser Phe
545 550 555 560
Gln Gln Lys Gln Thr Leu Gln Pro Val Pro Leu Gln Ala Thr Met Ser
565 570 575
Ala Ala Thr Gly Ile Gln Pro Ser Pro Val Ser Val Val Gly Ile Thr
580 585 590
Ala Ala Val Gly Gln Gln Pro Ser Val Ser Ser Leu Ala Gln Pro Gln
595 600 605
Leu Pro Tyr Ser Gln Thr Ala Pro Pro Val Gln Thr Pro Leu Pro Gly
610 615 620
Ala Pro Pro Gln Gln Leu Gln Tyr Gly Gln Gln Gln Pro Met Val Pro
625 630 635 640
Ala Gln Ile Ala Pro Gly His Gly Gln Pro Val Thr Gln Asn Pro Thr
645 650 655
Ser Glu Tyr Val Gln Gln Gln Gln Gln Pro Ile Phe Gln Ala Ala Leu
660 665 670
Ser Ser Gly Gln Ser Ser Ser Thr Gly Thr Gly Ala Gly Ile Ser Val
675 680 685
Ile Pro Val Ala Gln Ala Gln Gly Ile Gln Leu Pro Gly Gln Pro Thr
690 695 700
Ala Val Gln Thr Gln Pro Ala Gly Ala Ala Gly Gln Pro Ile Gly Gln
705 710 715 720
Ala Gln Thr Ala Val Ser Thr Val Pro Thr Gly Gly Gln Ile Ala Ser
725 730 735
Ile Gly Gln Gln Ala Asn Ile Pro Thr Ala Val Gln Gln Pro Ser Thr
740 745 750
Gln Val Thr Pro Ser Val Ile Gln Gln Gly Ala Pro Pro Ser Ser Gln
755 760 765
Val Val Leu Pro Ala Pro Thr Gly Ile Ile His Gln Gly Val Gln Thr
770 775 780
Arg Ala Ser Ser Leu Pro Gln Gln Leu Val Ile Ala Pro Gln Ser Thr
785 790 795 800
Leu Val Thr Val Pro Pro Gln Pro Gln Gly Val Glu Thr Val Ala Gln
805 810 815
Gly Val Val Ser Gln Gln Leu Pro Thr Gly Ser Pro Leu Pro Ser Ala
820 825 830
Ser Thr Ile Ser Val Thr Asn Gln Val Ser Ser Ala Ala Pro Ser Gly
835 840 845
Met Pro Ser Val Pro Thr Asn Leu Val Pro Pro Gln Asn Ile Ala Gln
850 855 860
Pro Pro Ala Thr Gln Asn Gly Ser Leu Val Gln Ser Val Ser Gln Ser
865 870 875 880
Pro Leu Ile Ala Thr Asn Ile Asn Leu Pro Leu Ala Gln Gln Ile Pro
885 890 895
Leu Ser Ser Thr Gln Phe Ser Thr Gln Ser Leu Ala Gln Ala Ile Gly
900 905 910
Ser Gln Met Glu Asp Ala Arg Arg Pro Ala Glu Pro Ser Leu Gly Gly
915 920 925
Leu Pro Gln Thr Met Ser Gly Asp Ser Gly Gly Met Ser Ala Val Ser
930 935 940
Asp Gly Ser Ser Ser Ser Leu Ala Ala Pro Ala Ser Leu Phe Pro Leu
945 950 955 960
Lys Val Leu Pro Leu Thr Thr Pro Leu Val Asp Gly Glu Asp Glu Ser
965 970 975
Ser Gly Ala Ser Val Val Ala Ile Asp Asn Lys Ile Glu Gln Ala Met
980 985 990
Asp Leu Val Lys Ser His Leu Met Tyr Ala Val Arg Glu Glu Val Glu
995 1000 1005
Val Leu Lys Glu Gln Ile Lys Glu Leu Ile Glu Lys Asn Ser Gln
1010 1015 1020
Leu Glu Gln Glu Asn Asn Leu Leu Lys Thr Leu Ala Ser Pro Glu
1025 1030 1035
Gln Leu Ala Gln Phe Gln Ala Gln Leu Gln Thr Gly Ser Pro Pro
1040 1045 1050
Ala Thr Thr Gln Pro Gln Gly Thr Thr Gln Pro Pro Ala Gln Pro
1055 1060 1065
Ala Ser Gln Gly Ser Gly Ser Thr Ala
1070 1075

Claims (32)

1.一种组合物，其包含至少两种转录因子：IRF8和SPIB；
所述组合物用于在受试者中将干细胞或分化的细胞或其混合物重新程序化成浆细胞样树突细胞或I型干扰素产生细胞。
2.根据权利要求1所述的组合物，其中所述组合物进一步包含一种或多种选自以下的其它转录因子：ARID5A、BCL11A、CBFA2T3、CREB3L2、ETS1、IKZF1、STAT1、TCF4、TCF12和TSC22D1。
3.根据前述权利要求中的任一项所述的组合物，其中所述转录因子分别与选自以下的序列具有至少90％同一性：IRF8(SEQ.ID.49,SEQ.ID.50)、SPIB(SEQ.ID.51,SEQ.ID.52)、ARID5A(SEQ.ID.53,SEQ.ID.54)、BCL11A(SEQ.ID.55,SEQ.ID.56)、CBFA2T3(SEQ.ID.57,SEQ.ID.58)、CREB3L2(SEQ.ID.59,SEQ.ID.60)、ETS1(SEQ.ID.61,SEQ.ID.62)、IKZF1(SEQ.ID.71,SEQ.ID.72)、TCF4(SEQ.ID.89,SEQ.ID.90)、TCF12(SEQ.ID.91,SEQ.ID.92)、STAT1(SEQ.ID.93,SEQ.ID.94)和TSC22D1(SEQ.ID.95,SEQ.ID.96)。
4.根据前述权利要求中的任一项所述的组合物，其中所述转录因子的组合选自以下组合：
IRF8和SPIB；
IRF8、SPIB和ARID5A；
IRF8、SPIB和BCL11A；
IRF8、SPIB和CBFA2T3；
IRF8、SPIB和CREB3L2；
IRF8、SPIB和ETS1；
IRF8、SPIB和IKZF1；
IRF8、SPIB和STAT1；
IRF8、SPIB和TCF4；
IRF8、SPIB和TCF12；
IRF8、SPIB和TSC22D1或其混合物。
5.根据前述权利要求中的任一项所述的组合物，其中所述转录因子的组合是IRF8、SPIB和TCF12的组合。
6.根据前述权利要求中的任一项所述的组合物，其中所述转录因子的组合是IRF8、SPIB和TSC22D1的组合。
7.根据前述权利要求中的任一项所述的组合物，其中所述细胞选自：多能干细胞、多潜能干细胞、分化的细胞、肿瘤细胞、癌症细胞及其混合物。
8.根据前述权利要求中的任一项所述的组合物，其用在兽医或人医学中，特别是在抗病毒免疫应答和免疫病理学的诊断、疗法或治疗中，尤其是自身免疫性疾病和免疫缺陷病况、瘤形成、特别是癌症、即实体或血液学肿瘤、良性肿瘤、恶性肿瘤、早期癌症、基底细胞癌、宫颈发育不良、软组织肉瘤、生殖细胞肿瘤、视网膜母细胞瘤、年龄相关性黄斑变性、霍奇金淋巴瘤、血癌、前列腺癌、卵巢癌、子宫颈癌、子宫癌、阴道癌、乳腺癌、鼻咽癌、气管癌、喉癌、支气管癌、细支气管癌、肺癌、中空器官癌、食管癌、胃癌、胆管癌、肠癌、结肠癌、结肠直肠癌、直肠癌、膀胱癌、输尿管癌、肾癌、肝癌、胆囊癌、脾癌、脑癌、淋巴系统癌症、骨癌、胰腺癌、白血病、皮肤癌或骨髓瘤、感染性疾病、病毒性疾病或病毒诱导的疾病、中枢和周围神经系统病症、真菌性、病毒性、衣原体性、细菌性、纳米细菌性或寄生性感染性疾病或病毒性疾病或病毒诱导的疾病的诊断、疗法或治疗中，用作抗病毒剂或用作免疫原性组合物，免疫疗法，或在神经变性疾病的治疗或疗法中，在癌症的治疗或疗法中，或在感染性疾病的治疗或疗法中，真皮内和透皮疗法中，HIV、SARS冠状病毒感染、亚洲流感病毒、单纯疱疹、流感病毒、带状疱疹、肝炎、人乳头瘤病毒、爱泼斯坦-巴尔病毒、人嗜T淋巴细胞病毒或病毒性肝炎、淀粉样蛋白疾病、尤其是淀粉样蛋白A淀粉样变性、阿尔茨海默氏病、轻链(AL)淀粉样变性、2型糖尿病、甲状腺管道样癌、帕金森病、多神经病或海绵状脑病-Creutzfeldt Jakob疾病的治疗或疗法中，或用于药物筛选。
9.编码至少两种转录因子SPIB和IRF8的构建体或载体。
10.根据权利要求9所述的构建体或载体，其中所述载体是病毒载体；特别是逆转录病毒、腺病毒、慢病毒、疱疹病毒、痘病毒、副粘病毒、棒状病毒、甲病毒、黄病毒或腺相关病毒载体。
11.根据前述权利要求9-10中的任一项所述的构建体或载体，其中所述载体或构建体是合成的mRNA、裸甲病毒RNA复制子或裸黄病毒RNA复制子。
12.一种或多种载体，其包含编码至少两种转录因子IRF8和SPIB的至少两种多核苷酸序列，所述载体用于在受试者中将干细胞或分化的细胞或其混合物重新程序化成浆细胞样树突细胞或I型干扰素产生细胞。
13.根据权利要求12所述的一种或多种载体，其中所述载体进一步编码一种或多种选自以下的其它转录因子：ARID5A、BCL11A、CBFA2T3、CREB3L2、ETS1、IKZF1、STAT1、TCF4、TCF12和TSC22D1。
14.根据前述权利要求12-13中的任一项所述的一种或多种载体，其中所述转录因子分别与选自以下的序列具有至少90％同一性：IRF8(SEQ.ID.1,SEQ.ID.2)、SPIB(SEQ.ID.3,SEQ.ID.4)、ARID5A(SEQ.ID.5,SEQ.ID.6)、BCL11A(SEQ.ID.7,SEQ.ID.8)、CBFA2T3(SEQ.ID.9,SEQ.ID.10)、CREB3L2(SEQ.ID.11,SEQ.ID.12)、ETS1(SEQ.ID.13,SEQ.ID.14)、IKZF1(SEQ.ID.23,SEQ.ID.24)、TCF4(SEQ.ID.41,SEQ.ID.42)、TCF12(SEQ.ID.43,SEQ.ID.44)、STAT1(SEQ.ID.45,SEQ.ID.46)和TSC22D1(SEQ.ID.47,SEQ.ID.48)。
15.根据前述权利要求12-14中的任一项所述的一种或多种载体，其中转录因子的组合选自以下组合：
IRF8和SPIB；
IRF8、SPIB和ARID5A；
IRF8、SPIB和BCL11A；
IRF8、SPIB和CBFA2T3；
IRF8、SPIB和CREB3L2；
IRF8、SPIB和ETS1；
IRF8、SPIB和IKZF1；
IRF8、SPIB和STAT1；
IRF8、SPIB和TCF4；
IRF8、SPIB和TCF12；
IRF8、SPIB和TSC22D1或其混合物。
16.根据前述权利要求12-15中的任一项所述的一种或多种载体，其中所述转录因子的组合是IRF8、SPIB和TCF12的组合。
17.根据前述权利要求12-16中的任一项所述的一种或多种载体，其中所述转录因子的组合是IRF8、SPIB和TSC22D1的组合。
18.根据前述权利要求12-17中的任一项所述的一种或多种载体，其中所述载体是病毒载体；特别是逆转录病毒、腺病毒、慢病毒、疱疹病毒、痘病毒、副粘病毒、棒状病毒、甲病毒、黄病毒或腺相关病毒载体。
19.根据前述权利要求12-18中的任一项所述的一种或多种载体，其中所述载体是合成的mRNA、裸甲病毒RNA复制子或裸黄病毒RNA复制子。
20.根据前述权利要求12-19中的任一项所述的一种或多种载体，其中所述细胞选自：多能干细胞、多潜能干细胞、分化的细胞、肿瘤细胞、癌症细胞及其混合物。
21.根据前述权利要求12-20中的任一项所述的一种或多种载体，所述载体用在兽医或人医学中，特别是在抗病毒免疫应答和免疫病理学的诊断、疗法或治疗中，尤其是自身免疫性疾病和免疫缺陷病况、瘤形成、特别是癌症(即实体或血液学肿瘤)、良性肿瘤、恶性肿瘤、早期癌症、基底细胞癌、宫颈发育不良、软组织肉瘤、生殖细胞肿瘤、视网膜母细胞瘤、年龄相关性黄斑变性、霍奇金淋巴瘤、血癌、前列腺癌、卵巢癌、子宫颈癌、子宫癌、阴道癌、乳腺癌、鼻咽癌、气管癌、喉癌、支气管癌、细支气管癌、肺癌、中空器官癌、食管癌、胃癌、胆管癌、肠癌、结肠癌、结肠直肠癌、直肠癌、膀胱癌、输尿管癌、肾癌、肝癌、胆囊癌、脾癌、脑癌、淋巴系统癌症、骨癌、胰腺癌、白血病、皮肤癌或骨髓瘤、感染性疾病、病毒性疾病或病毒诱导的疾病、中枢和周围神经系统病症、真菌性、病毒性、衣原体性、细菌性、纳米细菌性或寄生性感染性疾病或病毒性疾病或病毒诱导的疾病的诊断、疗法或治疗中，用作抗病毒剂或用作免疫原性组合物，免疫疗法，或在神经变性疾病的治疗或疗法中，在癌症的治疗或疗法中，或在感染性疾病的治疗或疗法中，真皮内和透皮疗法中，HIV、SARS冠状病毒感染、亚洲流感病毒、单纯疱疹、流感病毒、带状疱疹、肝炎、人乳头瘤病毒、爱泼斯坦-巴尔病毒、人嗜T淋巴细胞病毒或病毒性肝炎、淀粉样蛋白疾病、尤其是淀粉样蛋白A淀粉样变性、阿尔茨海默氏病、轻链(AL)淀粉样变性、2型糖尿病、甲状腺管道样癌、帕金森病、多神经病或海绵状脑病-Creutzfeldt Jakob疾病的治疗或疗法中，或用于药物筛选。
22.用于将细胞重新程序化或诱导成浆细胞样树突细胞或I型干扰素产生细胞的体外方法，所述方法包括下述步骤：
用一种或多种载体转导选自干细胞、分化的细胞、及其混合物的细胞，所述载体包含至少两种选自IRF8和SPIB的转录因子。
23.根据权利要求22所述的方法，其中所述一种或多种载体进一步包含一种或多种选自以下的转录因子：ARID5A、BCL11A、CBFA2T3、CREB3L2、ETS1、IKZF1、STAT1、TCF4、TCF12和TSC22D1。
24.根据前述权利要求22-23中的任一项所述的方法，其中所述转录因子分别与选自以下的序列具有至少90％同一性：IRF8(SEQ.ID.1,SEQ.ID.2)、SPIB(SEQ.ID.3,SEQ.ID.4)、ARID5A(SEQ.ID.5,SEQ.ID.6)、BCL11A(SEQ.ID.7,SEQ.ID.8)、CBFA2T3(SEQ.ID.9,SEQ.ID.10)、CREB3L2(SEQ.ID.11,SEQ.ID.12)、ETS1(SEQ.ID.13,SEQ.ID.14)、IKZF1(SEQ.ID.23,SEQ.ID.24)、TCF4(SEQ.ID.41,SEQ.ID.42)、TCF12(SEQ.ID.43,SEQ.ID.44)、STAT1(SEQ.ID.45,SEQ.ID.46)和TSC22D1(SEQ.ID.47,SEQ.ID.48)。
25.根据前述权利要求22-24中的任一项所述的方法，其中所述转录因子的组合选自以下组合：
IRF8和SPIB；
IRF8、SPIB和ARID5A；
IRF8、SPIB和BCL11A；
IRF8、SPIB和CBFA2T3；
IRF8、SPIB和CREB3L2；
IRF8、SPIB和ETS1；
IRF8、SPIB和IKZF1；
IRF8、SPIB和STAT1；
IRF8、SPIB和TCF4；
IRF8、SPIB和TCF12；
IRF8、SPIB和TSC22D1或其混合物。
26.根据前述权利要求22-25中的任一项所述的方法，所述方法包括将转导的细胞培养至少2天，优选至少5天，更优选至少8天，甚至更优选至少9天。
27.根据前述权利要求22-26中的任一项所述的方法，其中所述转导步骤进一步包含至少一种载体，所述载体选自：编码IL-12的核酸序列；编码IL-4的核酸序列；编码IFN-α的核酸序列；编码IFN-β的核酸序列；编码IFN-γ的核酸序列；编码TNF的核酸序列；编码GM-CSF的核酸序列；编码靶向IL-10RNA的siRNA的核酸序列，及其混合物，优选包含编码免疫刺激性细胞因子的核酸。
28.根据前述权利要求22-27中的任一项所述的方法，其中所述细胞是选自多能干细胞或多潜能干细胞、分化的细胞的哺乳动物细胞、人细胞、非人细胞或小鼠细胞，其中所述多能干细胞、多潜能干细胞或分化的细胞选自内胚层衍生的细胞、中胚层衍生的细胞或外胚层衍生的细胞、多潜能干细胞，包括间质干细胞、造血干细胞、肠干细胞、多能干细胞和细胞系；特别是中胚层衍生的细胞，优选单核细胞及其混合物。
29.通过权利要求22-28中的任一项中所述的方法得到的诱导的浆细胞样树突细胞或I型干扰素产生细胞。
30.一种组合物，其包含治疗有效量的根据权利要求29所述的浆细胞样树突细胞或I型干扰素产生细胞，进一步包含药学上可接受的赋形剂、镇痛剂、抗炎剂、化疗剂、放疗剂、抗生素、利尿剂、填充剂、粘合剂、崩解剂或润滑剂或其混合物。
31.疫苗或可注射制剂，特别是原位注射剂，其包含根据权利要求1-8和30中的任一项所述的组合物、和/或根据权利要求29所述的诱导的浆细胞样树突细胞或I型干扰素产生细胞、或其混合物。
32.一种试剂盒，其包含下述组分中的至少一种：
根据权利要求29所述的诱导的浆细胞样树突细胞或I型干扰素产生细胞；
根据权利要求1-8和30中的任一项所述的组合物；
根据权利要求9-21所述的载体或构建体；或其混合物。
CN202080080049.6A 2019-10-10 2020-10-09 用于将细胞重新程序化成浆细胞样树突细胞或i型干扰素产生细胞的组合物、方法及其用途 Pending CN114729322A (zh)

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